GCF_001949975.2 - 3 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_AP019008.1 (Apilactobacillus kunkeei)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	lanthipeptide-class-i	1	19,498	Low	cesin A	ribosomal:RiPP

NZ_BDDX01000012.1 (Apilactobacillus kunkeei)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 13.1	lanthipeptide-class-i	1	19,484	Low	cesin A	ribosomal:RiPP

NZ_BDDX01000016.1 (Apilactobacillus kunkeei)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 17.1	terpene-precursor	120,919	141,132

No secondary metabolite regions were found in these records:: NZ_BDDX01000001.1 (Apilactobacillus kunkeei); NZ_BDDX01000002.1 (Apilactobacillus kunkeei); NZ_BDDX01000003.1 (Apilactobacillus kunkeei); NZ_BDDX01000004.1 (Apilactobacillus kunkeei); NZ_BDDX01000005.1 (Apilactobacillus kunkeei); NZ_BDDX01000006.1 (Apilactobacillus kunkeei); NZ_BDDX01000007.1 (Apilactobacillus kunkeei); NZ_BDDX01000008.1 (Apilactobacillus kunkeei); NZ_BDDX01000009.1 (Apilactobacillus kunkeei); NZ_BDDX01000010.1 (Apilactobacillus kunkeei); NZ_BDDX01000011.1 (Apilactobacillus kunkeei); NZ_BDDX01000013.1 (Apilactobacillus kunkeei); NZ_BDDX01000014.1 (Apilactobacillus kunkeei); NZ_BDDX01000015.1 (Apilactobacillus kunkeei); NZ_BDDX01000017.1 (Apilactobacillus kunkeei); NZ_BDDX01000018.1 (Apilactobacillus kunkeei); NZ_BDDX01000019.1 (Apilactobacillus kunkeei); NZ_BDDX01000020.1 (Apilactobacillus kunkeei); NZ_BDDX01000021.1 (Apilactobacillus kunkeei); NZ_BDDX01000022.1 (Apilactobacillus kunkeei); NZ_BDDX01000023.1 (Apilactobacillus kunkeei); NZ_BDDX01000024.1 (Apilactobacillus kunkeei); NZ_BDDX01000025.1 (Apilactobacillus kunkeei)

Compact view

NZ_AP019008.1 - Region 1 - lanthipeptide-class-i

Download region GenBank file

Download region SVG

Location: 1 - 19,498 nt. (total: 19,498 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: protease

FF306_RS00055: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase dehydratase

FF306_RS00065: Lanthionine synthetase C family protein

smcogs: SMCOG1140: Lanthionine synthetase C family protein

FF306_RS00090: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000538.3	0.55	ribosomal	nisin Z	Lactococcus lactis
BGC0000542.3	0.51	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000556.5	0.50	ribosomal	streptin	Streptococcus pyogenes
BGC0002323.2	0.50	ribosomal	nisin J	Staphylococcus capitis
BGC0000506.4	0.48	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0001618.3	0.48	ribosomal	hyicin 3682	Staphylococcus hyicus
BGC0002635.2	0.47	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa
BGC0001210.5	0.47	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000541.5	0.47	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000539.5	0.46	ribosomal	nukacin ISK-1	Staphylococcus warneri

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000538.3	0.55	ribosomal	nisin Z	Lactococcus lactis
BGC0000542.3	0.51	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000556.5	0.50	ribosomal	streptin	Streptococcus pyogenes
BGC0002323.2	0.50	ribosomal	nisin J	Staphylococcus capitis
BGC0000506.4	0.48	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0001618.3	0.48	ribosomal	hyicin 3682	Staphylococcus hyicus
BGC0002635.2	0.47	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa
BGC0001210.5	0.47	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000541.5	0.47	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000539.5	0.46	ribosomal	nukacin ISK-1	Staphylococcus warneri

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for FF306_RS00090

FF306_RS00060

Leader:

MEVIDMSNFNDFNLGIKKVHSGSKKGLEPR

Core:

ITSYVLCTPGCITGRLMGCNNKTKTCHCHSSNHFSFHAR

Core with dehydrations:

IDhbDhaYVLCysDhbPGCysIDhbGRLMGCysNNKDhbKDhbCysHCysHDhaDhaNHFDhaFHAR

antiSMASH-DB 4.0 matches for FF306_RS00060

100.0%

NZ_AP019008.1and 1 other:

NZ_BDDX01000012.1 Lanthipeptides: FF306_RS05510_lanthipeptide

Lanthipeptides: FF306_RS00060_lanthipeptide

ITSYVLCTPGCITGRLMGCNNKTKTCHCHSSNHFSFHAR

94.9%

NZ_JXCW01000008.1:

Lanthipeptides: RZ55_RS07215_lanthipeptide

ITSYVLCTPGCITGRLMGCNNKTKTCHCHSSNHFSFHAR

ITSYVLCTPGCITGRLMGCNNKTKTCHCHSS++FSFHAR

ITSYVLCTPGCITGRLMGCNNKTKTCHCHSSHNFSFHAR

56.4%

NZ_CP065984.1and 2 others:

NZ_CP095737.1 Lanthipeptides: MXM90_RS03205_lanthipeptideNZ_JAQDXJ010000021.1 Lanthipeptides: PGU19_RS11740_lanthipeptide

Lanthipeptides: I6I21_RS02785_lanthipeptide

ITSYVLCTPGCITGRLMGCNNKTKTCHC

ITS LCTPGC TG LMGCN KT TCHC

ITSISLCTPGCKTGALMGCNMKTATCHC

with 117 more sequence matches

Only the first 10 are displayed here.

56.4%

NZ_FNDP01000013.1:

Lanthipeptides: BLP54_RS11230_lanthipeptide

ITSYVLCTPGCITGRLMGCNNKTKTCHC

ITS LCTPGC+TG LMGCNNKT TC+C

ITSKSLCTPGCVTGVLMGCNNKTATCNC

53.8%

NC_013656.1and 20 others:

NC_020450.1 Lanthipeptides: LILO_RS03015_lanthipeptideNZ_CP009472.1 Lanthipeptides: LG36_RS03420_lanthipeptideNZ_CP010050.1 Lanthipeptides: QI18_RS03300_lanthipeptideNZ_CP015903.1 Lanthipeptides: LLUC08_RS03255_lanthipeptideNZ_CP024954.1 Lanthipeptides: CV702_RS02990_lanthipeptideNZ_CP066300.1 Lanthipeptides: LacL0098_RS03205_lanthipeptideNZ_CP098790.1 Lanthipeptides: M5C73_RS03405_lanthipeptideNZ_JAALEQ010000006.1 Lanthipeptides: HFD15_RS10120_lanthipeptideNZ_JAJONJ010000005.1 Lanthipeptides: LSG16_RS07195_lanthipeptideNZ_JAQDWM010000007.1 Lanthipeptides: PGU01_RS08180_lanthipeptideNZ_JAQDXV010000018.1 Lanthipeptides: PGT80_RS11850_lanthipeptideNZ_JAQDYA010000007.1 Lanthipeptides: PGT72_RS09560_lanthipeptideNZ_JAQDYA010000007.1 Lanthipeptides: PGT72_RS09560_lanthipeptideNZ_JAQEIZ010000019.1 Lanthipeptides: PGX18_RS12025_lanthipeptideNZ_JAQEOU010000022.1 Lanthipeptides: PGV42_RS12330_lanthipeptideNZ_JAQEOV010000015.1 Lanthipeptides: PGW09_RS10765_lanthipeptideNZ_MTJP01000006.1 Lanthipeptides: BW151_RS03795_lanthipeptideNZ_MTJR01000005.1 Lanthipeptides: BW153_RS02980_lanthipeptideNZ_MTJS01000002.1 Lanthipeptides: BW154_RS09850_lanthipeptideNZ_RAGL01000022.1 Lanthipeptides: D6108_RS11395_lanthipeptide

Lanthipeptides: LLKF_RS13210_lanthipeptide

ITSYVLCTPGCITGRLMGCNNKTKTCHC

ITS LCTPGC TG LMGCN KT TC+C

ITSISLCTPGCKTGALMGCNMKTATCNC

53.8%

NZ_CP059471.1and 3 others:

NZ_FNZW01000001.1 Lanthipeptides: BMZ61_RS02110_lanthipeptideNZ_FOYC01000001.1 Lanthipeptides: BMZ88_RS03370_lanthipeptideNZ_KE384124.1 Lanthipeptides: G597_RS0106700_lanthipeptide

Lanthipeptides: H1R75_RS06635_lanthipeptide

ITSYVLCTPGCITGRLMGCNNKTKTCHCHSSN

ITS LCTPGC TG LM C KT TC CH N

ITSKSLCTPGCKTGALMTCPIKTATCGCHFGN

53.8%

NZ_CP090412.1and 3 others:

NZ_QSTB01000004.1 Lanthipeptides: DXC22_RS03785_lanthipeptideNZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptideNZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptide

Lanthipeptides: LZF92_RS09890_lanthipeptide

ITSYVLCTPGCITGRLMGCNNKTKTCHCH

ITSY LCTPGC TG LMGC KT +C CH

ITSYSLCTPGCKTGALMGCTMKTASCGCH

53.8%

NZ_FBTD01000003.1:

Lanthipeptides: PB1E_RS03075_lanthipeptide

ITSYVLCTPGCITGRLMGCNNKTKTCHCH

ITS LCTPGC TG LMGCN KT +C CH

ITSVSLCTPGCKTGALMGCNMKTASCGCH

51.3%

NZ_CP013655.1and 2 others:

NZ_CP013655.1 Lanthipeptides: ATZ35_RS03635_lanthipeptideNZ_CP013655.1 Lanthipeptides: ATZ35_RS03630_lanthipeptide

Lanthipeptides: ATZ35_RS03640_lanthipeptide

ITSYVLCTPGCITGRLMGCNNKTKTCHCH

ITS LCTPGC+TG LMGC KT TC+C

ITSKSLCTPGCVTGVLMGCALKTITCNCS

51.3%

NZ_JADNFO010000025.1:

Lanthipeptides: I2C89_RS09745_lanthipeptide

ITSYVLCTPGCITGRLMGCNNKTKTCHC

ITSY LCTPGC TG LM C+ KT TC+C

ITSYSLCTPGCKTGVLMACHLKTATCNC

51.3%

NZ_LR793265.1:

Lanthipeptides: HV392_RS09825_lanthipeptide

ITSYVLCTPGCITGRLMGCNNKTKTCHCH

ITSY LCTPGCITGRLMGC ++ C+ H

ITSYSLCTPGCITGRLMGCQFQSAGCNVH

48.7%

NC_015600.1and 14 others:

NZ_AP020310.1 Lanthipeptides: SAGCMC97051_RS07300_lanthipeptideNZ_ATVP01000001.1 Lanthipeptides: G574_RS11150_lanthipeptideNZ_BCFB01000042.1 Lanthipeptides: GOZ36_RS07980_lanthipeptideNZ_CP068708.1 Lanthipeptides: JM964_RS04040_lanthipeptideNZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptideNZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptideNZ_FIKS01000005.1 Lanthipeptides: A0525_RS10015_lanthipeptideNZ_GL636070.1 Lanthipeptides: HMPREF9171_RS106200_lanthipeptideNZ_JADPLU010000018.1 Lanthipeptides: I4V82_RS09545_lanthipeptideNZ_JAKVIE010000017.1 Lanthipeptides: MK857_RS08340_lanthipeptideNZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptideNZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptideNZ_LR594050.1 Lanthipeptides: FGL20_RS03485_lanthipeptideNZ_SSXN01000004.1 Lanthipeptides: FAJ36_RS04715_lanthipeptide

Lanthipeptides: SGPB_RS10680_lanthipeptide

ITSYVLCTPGCITGRLMGCNNKTKTCHCH

+TS LCTPGC TG LM C KT TC CH

VTSKSLCTPGCKTGILMTCAIKTATCGCH

48.7%

NC_022237.1and 1 other:

NZ_JUZI01000019.1 Lanthipeptides: ADI02_RS09325_lanthipeptide

Lanthipeptides: SII_RS05025_lanthipeptide

ITSYVLCTPGCITGRLMGCNNKTKTCHCH

+TS +CTPGC+TG LMGCN +T TC+CH

VTSVFMCTPGCVTGALMGCNLQTATCNCH

MIBiG 4.0 matches for FF306_RS00060

56.4%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

ITSYVLCTPGCITGRLMGCNNKTKTCHC

ITS LCTPGC TG LMGCN KT TCHC

ITSISLCTPGCKTGALMGCNMKTATCHC

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.97 out of 29.38

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.07 out of 24.78

Confidence: medium

Additional weak hits (1):

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.70 out of 27.55

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

FF306_RS00060 - Class I

Cleavage pHMM score: 9.10

RODEO score: 17

Monoisotopic mass: 4162.0 Da

Molecular weight: 4164.8 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 4182.8 Da N = 1; 4200.8 Da N = 2; 4218.8 Da N = 3; 4236.9 Da N = 4

TFBS definitions

Regulator	Description
FuR variant 1	Ferric Uptake Regulator
LexA variant 2	Repressor of DNA damage response

NZ_BDDX01000012.1 - Region 1 - lanthipeptide-class-i

Download region GenBank file

Download region SVG

Location: 1 - 19,484 nt. (total: 19,484 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: protease

FF306_RS05505: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase dehydratase

FF306_RS05515: Lanthionine synthetase C family protein

smcogs: SMCOG1140: Lanthionine synthetase C family protein

FF306_RS05540: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000538.3	0.55	ribosomal	nisin Z	Lactococcus lactis
BGC0000542.3	0.51	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000556.5	0.50	ribosomal	streptin	Streptococcus pyogenes
BGC0002323.2	0.50	ribosomal	nisin J	Staphylococcus capitis
BGC0000506.4	0.48	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0001618.3	0.48	ribosomal	hyicin 3682	Staphylococcus hyicus
BGC0002635.2	0.47	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa
BGC0001210.5	0.47	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000541.5	0.47	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000539.5	0.46	ribosomal	nukacin ISK-1	Staphylococcus warneri

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000538.3	0.55	ribosomal	nisin Z	Lactococcus lactis
BGC0000542.3	0.51	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000556.5	0.50	ribosomal	streptin	Streptococcus pyogenes
BGC0002323.2	0.50	ribosomal	nisin J	Staphylococcus capitis
BGC0000506.4	0.48	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0001618.3	0.48	ribosomal	hyicin 3682	Staphylococcus hyicus
BGC0002635.2	0.47	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa
BGC0001210.5	0.47	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000541.5	0.47	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000539.5	0.46	ribosomal	nukacin ISK-1	Staphylococcus warneri

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for FF306_RS05540

FF306_RS05510

Leader:

MEVIDMSNFNDFNLGIKKVHSGSKKGLEPR

Core:

ITSYVLCTPGCITGRLMGCNNKTKTCHCHSSNHFSFHAR

Core with dehydrations:

IDhbDhaYVLCysDhbPGCysIDhbGRLMGCysNNKDhbKDhbCysHCysHDhaDhaNHFDhaFHAR

antiSMASH-DB 4.0 matches for FF306_RS05510

100.0%

NZ_AP019008.1and 1 other:

NZ_BDDX01000012.1 Lanthipeptides: FF306_RS05510_lanthipeptide

Lanthipeptides: FF306_RS00060_lanthipeptide

ITSYVLCTPGCITGRLMGCNNKTKTCHCHSSNHFSFHAR

94.9%

NZ_JXCW01000008.1:

Lanthipeptides: RZ55_RS07215_lanthipeptide

ITSYVLCTPGCITGRLMGCNNKTKTCHCHSSNHFSFHAR

ITSYVLCTPGCITGRLMGCNNKTKTCHCHSS++FSFHAR

ITSYVLCTPGCITGRLMGCNNKTKTCHCHSSHNFSFHAR

56.4%

NZ_CP065984.1and 2 others:

NZ_CP095737.1 Lanthipeptides: MXM90_RS03205_lanthipeptideNZ_JAQDXJ010000021.1 Lanthipeptides: PGU19_RS11740_lanthipeptide

Lanthipeptides: I6I21_RS02785_lanthipeptide

ITSYVLCTPGCITGRLMGCNNKTKTCHC

ITS LCTPGC TG LMGCN KT TCHC

ITSISLCTPGCKTGALMGCNMKTATCHC

with 117 more sequence matches

Only the first 10 are displayed here.

56.4%

NZ_FNDP01000013.1:

Lanthipeptides: BLP54_RS11230_lanthipeptide

ITSYVLCTPGCITGRLMGCNNKTKTCHC

ITS LCTPGC+TG LMGCNNKT TC+C

ITSKSLCTPGCVTGVLMGCNNKTATCNC

53.8%

NC_013656.1and 20 others:

Lanthipeptides: LLKF_RS13210_lanthipeptide

ITSYVLCTPGCITGRLMGCNNKTKTCHC

ITS LCTPGC TG LMGCN KT TC+C

ITSISLCTPGCKTGALMGCNMKTATCNC

53.8%

NZ_CP059471.1and 3 others:

NZ_FNZW01000001.1 Lanthipeptides: BMZ61_RS02110_lanthipeptideNZ_FOYC01000001.1 Lanthipeptides: BMZ88_RS03370_lanthipeptideNZ_KE384124.1 Lanthipeptides: G597_RS0106700_lanthipeptide

Lanthipeptides: H1R75_RS06635_lanthipeptide

ITSYVLCTPGCITGRLMGCNNKTKTCHCHSSN

ITS LCTPGC TG LM C KT TC CH N

ITSKSLCTPGCKTGALMTCPIKTATCGCHFGN

53.8%

NZ_CP090412.1and 3 others:

NZ_QSTB01000004.1 Lanthipeptides: DXC22_RS03785_lanthipeptideNZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptideNZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptide

Lanthipeptides: LZF92_RS09890_lanthipeptide

ITSYVLCTPGCITGRLMGCNNKTKTCHCH

ITSY LCTPGC TG LMGC KT +C CH

ITSYSLCTPGCKTGALMGCTMKTASCGCH

53.8%

NZ_FBTD01000003.1:

Lanthipeptides: PB1E_RS03075_lanthipeptide

ITSYVLCTPGCITGRLMGCNNKTKTCHCH

ITS LCTPGC TG LMGCN KT +C CH

ITSVSLCTPGCKTGALMGCNMKTASCGCH

51.3%

NZ_CP013655.1and 2 others:

NZ_CP013655.1 Lanthipeptides: ATZ35_RS03635_lanthipeptideNZ_CP013655.1 Lanthipeptides: ATZ35_RS03630_lanthipeptide

Lanthipeptides: ATZ35_RS03640_lanthipeptide

ITSYVLCTPGCITGRLMGCNNKTKTCHCH

ITS LCTPGC+TG LMGC KT TC+C

ITSKSLCTPGCVTGVLMGCALKTITCNCS

51.3%

NZ_JADNFO010000025.1:

Lanthipeptides: I2C89_RS09745_lanthipeptide

ITSYVLCTPGCITGRLMGCNNKTKTCHC

ITSY LCTPGC TG LM C+ KT TC+C

ITSYSLCTPGCKTGVLMACHLKTATCNC

51.3%

NZ_LR793265.1:

Lanthipeptides: HV392_RS09825_lanthipeptide

ITSYVLCTPGCITGRLMGCNNKTKTCHCH

ITSY LCTPGCITGRLMGC ++ C+ H

ITSYSLCTPGCITGRLMGCQFQSAGCNVH

48.7%

NC_015600.1and 14 others:

Lanthipeptides: SGPB_RS10680_lanthipeptide

ITSYVLCTPGCITGRLMGCNNKTKTCHCH

+TS LCTPGC TG LM C KT TC CH

VTSKSLCTPGCKTGILMTCAIKTATCGCH

48.7%

NC_022237.1and 1 other:

NZ_JUZI01000019.1 Lanthipeptides: ADI02_RS09325_lanthipeptide

Lanthipeptides: SII_RS05025_lanthipeptide

ITSYVLCTPGCITGRLMGCNNKTKTCHCH

+TS +CTPGC+TG LMGCN +T TC+CH

VTSVFMCTPGCVTGALMGCNLQTATCNCH

MIBiG 4.0 matches for FF306_RS05510

56.4%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

ITSYVLCTPGCITGRLMGCNNKTKTCHC

ITS LCTPGC TG LMGCN KT TCHC

ITSISLCTPGCKTGALMGCNMKTATCHC

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.97 out of 29.38

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.07 out of 24.78

Confidence: medium

Additional weak hits (1):

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.70 out of 27.55

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

FF306_RS05510 - Class I

Cleavage pHMM score: 9.10

RODEO score: 17

Monoisotopic mass: 4162.0 Da

Molecular weight: 4164.8 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 4182.8 Da N = 1; 4200.8 Da N = 2; 4218.8 Da N = 3; 4236.9 Da N = 4

TFBS definitions

Regulator	Description
FuR variant 1	Ferric Uptake Regulator
LexA variant 2	Repressor of DNA damage response

NZ_BDDX01000016.1 - Region 1 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 120,919 - 141,132 nt. (total: 20,214 nt) Show pHMM detection rules used

Region on contig edge.

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: formyltransferase

FF306_RS07095: methionyl-tRNA formyltransferase

smcogs: SMCOG1228: methionyl-tRNA formyltransferase

Ligases: synthetase

FF306_RS07130: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001605.3	0.38	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0000678.5	0.36	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000531.3	0.35	ribosomal	mutacin I	Streptococcus mutans
BGC0000665.5	0.35	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000533.3	0.34	ribosomal	mutacin III	Streptococcus mutans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001605.3	0.38	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0000678.5	0.36	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000531.3	0.35	ribosomal	mutacin I	Streptococcus mutans
BGC0000665.5	0.35	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000533.3	0.34	ribosomal	mutacin III	Streptococcus mutans

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

FF306_RS07130: PT_FPPS_like

Domain 1 (35 - 290): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

Binding sites found:

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 25.53 out of 30.25

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.95 out of 28.19

Confidence: medium

Additional weak hits (3):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.23 out of 26.85

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 24.22 out of 35.63

Confidence: weak

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.87 out of 18.46

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
ColR	Phenol-responsive regulator
ZuR variant 1	Zinc-responsive repressor