Select genomic region:
Overview
1.1
13.1
17.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_AP019008.1 (Apilactobacillus kunkeei)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | lanthipeptide-class-i | 1 | 19,498 | Low | cesin A | ribosomal:RiPP

NZ_BDDX01000012.1 (Apilactobacillus kunkeei)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 13.1 | lanthipeptide-class-i | 1 | 19,484 | Low | cesin A | ribosomal:RiPP

NZ_BDDX01000016.1 (Apilactobacillus kunkeei)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 17.1 | terpene-precursor | 120,919 | 141,132 |

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | lanthipeptide-class-i | 1 | 19,498 | Low | cesin A | ribosomal:RiPP
Region 13.1 | lanthipeptide-class-i | 1 | 19,484 | Low | cesin A | ribosomal:RiPP
Region 17.1 | terpene-precursor | 120,919 | 141,132 |

No secondary metabolite regions were found in these records:
  NZ_BDDX01000001.1 (Apilactobacillus kunkeei)
  NZ_BDDX01000002.1 (Apilactobacillus kunkeei)
  NZ_BDDX01000003.1 (Apilactobacillus kunkeei)
  NZ_BDDX01000004.1 (Apilactobacillus kunkeei)
  NZ_BDDX01000005.1 (Apilactobacillus kunkeei)
  NZ_BDDX01000006.1 (Apilactobacillus kunkeei)
  NZ_BDDX01000007.1 (Apilactobacillus kunkeei)
  NZ_BDDX01000008.1 (Apilactobacillus kunkeei)
  NZ_BDDX01000009.1 (Apilactobacillus kunkeei)
  NZ_BDDX01000010.1 (Apilactobacillus kunkeei)
  NZ_BDDX01000011.1 (Apilactobacillus kunkeei)
  NZ_BDDX01000013.1 (Apilactobacillus kunkeei)
  NZ_BDDX01000014.1 (Apilactobacillus kunkeei)
  NZ_BDDX01000015.1 (Apilactobacillus kunkeei)
  NZ_BDDX01000017.1 (Apilactobacillus kunkeei)
  NZ_BDDX01000018.1 (Apilactobacillus kunkeei)
  NZ_BDDX01000019.1 (Apilactobacillus kunkeei)
  NZ_BDDX01000020.1 (Apilactobacillus kunkeei)
  NZ_BDDX01000021.1 (Apilactobacillus kunkeei)
  NZ_BDDX01000022.1 (Apilactobacillus kunkeei)
  NZ_BDDX01000023.1 (Apilactobacillus kunkeei)
  NZ_BDDX01000024.1 (Apilactobacillus kunkeei)
  NZ_BDDX01000025.1 (Apilactobacillus kunkeei)

Compact view
NZ_AP019008.1 - Region 1 - lanthipeptide-class-i
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 19,498 nt. (total: 19,498 nt) Show pHMM detection rules used
Region on contig edge.
lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: protease
FF306_RS00055: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase dehydratase
FF306_RS00065: Lanthionine synthetase C family protein

smcogs
  SMCOG1140: Lanthionine synthetase C family protein

FF306_RS00090: Lantibiotic dehydratase domain protein

smcogs
  SMCOG1155: Lantibiotic dehydratase domain protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-i | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000538.3 |  | 0.55 | ribosomal | nisin Z | Lactococcus lactis
BGC0000542.3 |  | 0.51 | ribosomal | paenicidin B | Paenibacillus terrae
BGC0000556.5 |  | 0.50 | ribosomal | streptin | Streptococcus pyogenes
BGC0002323.2 |  | 0.50 | ribosomal | nisin J | Staphylococcus capitis
BGC0000506.4 |  | 0.48 | ribosomal | entianin | Bacillus subtilis subsp. spizizenii
BGC0001618.3 |  | 0.48 | ribosomal | hyicin 3682 | Staphylococcus hyicus
BGC0002635.2 |  | 0.47 | ribosomal | daspyromycin A, daspyromycin B | Actinokineospora diospyrosa
BGC0001210.5 |  | 0.47 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000541.5 |  | 0.47 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0000539.5 |  | 0.46 | ribosomal | nukacin ISK-1 | Staphylococcus warneri

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000538.3 |  | 0.55 | ribosomal | nisin Z | Lactococcus lactis
BGC0000542.3 |  | 0.51 | ribosomal | paenicidin B | Paenibacillus terrae
BGC0000556.5 |  | 0.50 | ribosomal | streptin | Streptococcus pyogenes
BGC0002323.2 |  | 0.50 | ribosomal | nisin J | Staphylococcus capitis
BGC0000506.4 |  | 0.48 | ribosomal | entianin | Bacillus subtilis subsp. spizizenii
BGC0001618.3 |  | 0.48 | ribosomal | hyicin 3682 | Staphylococcus hyicus
BGC0002635.2 |  | 0.47 | ribosomal | daspyromycin A, daspyromycin B | Actinokineospora diospyrosa
BGC0001210.5 |  | 0.47 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000541.5 |  | 0.47 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0000539.5 |  | 0.46 | ribosomal | nukacin ISK-1 | Staphylococcus warneri

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for FF306_RS00090

FF306_RS00060
Leader:
MEVIDMSNFNDFNLGIKKVHSGSKKGLEPR
Core:
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C H S S N H F S F H A R
Core with dehydrations:
I Dhb Dha Y V L Cys Dhb P G Cys I Dhb G R L M G Cys N N K Dhb K Dhb Cys H Cys H Dha Dha N H F Dha F H A R

#### antiSMASH-DB 4.0 matches for FF306_RS00060

100.0%
NZ_AP019008.1 and 1 other:
NZ_BDDX01000012.1 Lanthipeptides: FF306_RS05510_lanthipeptide
Lanthipeptides: FF306_RS00060_lanthipeptide
1
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C H S S N H F S F H A R
39
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C H S S N H F S F H A R
1
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C H S S N H F S F H A R
39
94.9%
NZ_JXCW01000008.1:
Lanthipeptides: RZ55_RS07215_lanthipeptide
1
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C H S S N H F S F H A R
39
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C H S S++F S F H A R
1
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C H S S H N F S F H A R
39
56.4%
NZ_CP065984.1 and 2 others:
NZ_CP095737.1 Lanthipeptides: MXM90_RS03205_lanthipeptide NZ_JAQDXJ010000021.1 Lanthipeptides: PGU19_RS11740_lanthipeptide
Lanthipeptides: I6I21_RS02785_lanthipeptide
1
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C
28
I T S L C T P G C T G L M G C N K T T C H C
1
I T S I S L C T P G C K T G A L M G C N M K T A T C H C
28
with 117 more sequence matches
Only the first 10 are displayed here.
56.4%
NZ_FNDP01000013.1:
Lanthipeptides: BLP54_RS11230_lanthipeptide
1
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C
28
I T S L C T P G C+T G L M G C N N K T T C+C
3
I T S K S L C T P G C V T G V L M G C N N K T A T C N C
30
53.8%
NC_013656.1 and 20 others:
NC_020450.1 Lanthipeptides: LILO_RS03015_lanthipeptide NZ_CP009472.1 Lanthipeptides: LG36_RS03420_lanthipeptide NZ_CP010050.1 Lanthipeptides: QI18_RS03300_lanthipeptide NZ_CP015903.1 Lanthipeptides: LLUC08_RS03255_lanthipeptide NZ_CP024954.1 Lanthipeptides: CV702_RS02990_lanthipeptide NZ_CP066300.1 Lanthipeptides: LacL0098_RS03205_lanthipeptide NZ_CP098790.1 Lanthipeptides: M5C73_RS03405_lanthipeptide NZ_JAALEQ010000006.1 Lanthipeptides: HFD15_RS10120_lanthipeptide NZ_JAJONJ010000005.1 Lanthipeptides: LSG16_RS07195_lanthipeptide NZ_JAQDWM010000007.1 Lanthipeptides: PGU01_RS08180_lanthipeptide NZ_JAQDXV010000018.1 Lanthipeptides: PGT80_RS11850_lanthipeptide NZ_JAQDYA010000007.1 Lanthipeptides: PGT72_RS09560_lanthipeptide NZ_JAQDYA010000007.1 Lanthipeptides: PGT72_RS09560_lanthipeptide NZ_JAQEIZ010000019.1 Lanthipeptides: PGX18_RS12025_lanthipeptide NZ_JAQEOU010000022.1 Lanthipeptides: PGV42_RS12330_lanthipeptide NZ_JAQEOV010000015.1 Lanthipeptides: PGW09_RS10765_lanthipeptide NZ_MTJP01000006.1 Lanthipeptides: BW151_RS03795_lanthipeptide NZ_MTJR01000005.1 Lanthipeptides: BW153_RS02980_lanthipeptide NZ_MTJS01000002.1 Lanthipeptides: BW154_RS09850_lanthipeptide NZ_RAGL01000022.1 Lanthipeptides: D6108_RS11395_lanthipeptide
Lanthipeptides: LLKF_RS13210_lanthipeptide
1
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C
28
I T S L C T P G C T G L M G C N K T T C+C
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C
28
53.8%
NZ_CP059471.1 and 3 others:
NZ_FNZW01000001.1 Lanthipeptides: BMZ61_RS02110_lanthipeptide NZ_FOYC01000001.1 Lanthipeptides: BMZ88_RS03370_lanthipeptide NZ_KE384124.1 Lanthipeptides: G597_RS0106700_lanthipeptide
Lanthipeptides: H1R75_RS06635_lanthipeptide
1
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C H S S N
32
I T S L C T P G C T G L M C K T T C C H N
1
I T S K S L C T P G C K T G A L M T C P I K T A T C G C H F G N
32
53.8%
NZ_CP090412.1 and 3 others:
NZ_QSTB01000004.1 Lanthipeptides: DXC22_RS03785_lanthipeptide NZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptide NZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptide
Lanthipeptides: LZF92_RS09890_lanthipeptide
1
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C H
29
I T S Y L C T P G C T G L M G C K T +C C H
1
I T S Y S L C T P G C K T G A L M G C T M K T A S C G C H
29
53.8%
NZ_FBTD01000003.1:
Lanthipeptides: PB1E_RS03075_lanthipeptide
1
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C H
29
I T S L C T P G C T G L M G C N K T +C C H
1
I T S V S L C T P G C K T G A L M G C N M K T A S C G C H
29
51.3%
NZ_CP013655.1 and 2 others:
NZ_CP013655.1 Lanthipeptides: ATZ35_RS03635_lanthipeptide NZ_CP013655.1 Lanthipeptides: ATZ35_RS03630_lanthipeptide
Lanthipeptides: ATZ35_RS03640_lanthipeptide
1
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C H
29
I T S L C T P G C+T G L M G C K T T C+C
1
I T S K S L C T P G C V T G V L M G C A L K T I T C N C S
29
51.3%
NZ_JADNFO010000025.1:
Lanthipeptides: I2C89_RS09745_lanthipeptide
1
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C
28
I T S Y L C T P G C T G L M C+ K T T C+C
1
I T S Y S L C T P G C K T G V L M A C H L K T A T C N C
28
51.3%
NZ_LR793265.1:
Lanthipeptides: HV392_RS09825_lanthipeptide
1
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C H
29
I T S Y L C T P G C I T G R L M G C ++ C+ H
1
I T S Y S L C T P G C I T G R L M G C Q F Q S A G C N V H
29
48.7%
NC_015600.1 and 14 others:
NZ_AP020310.1 Lanthipeptides: SAGCMC97051_RS07300_lanthipeptide NZ_ATVP01000001.1 Lanthipeptides: G574_RS11150_lanthipeptide NZ_BCFB01000042.1 Lanthipeptides: GOZ36_RS07980_lanthipeptide NZ_CP068708.1 Lanthipeptides: JM964_RS04040_lanthipeptide NZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptide NZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptide NZ_FIKS01000005.1 Lanthipeptides: A0525_RS10015_lanthipeptide NZ_GL636070.1 Lanthipeptides: HMPREF9171_RS106200_lanthipeptide NZ_JADPLU010000018.1 Lanthipeptides: I4V82_RS09545_lanthipeptide NZ_JAKVIE010000017.1 Lanthipeptides: MK857_RS08340_lanthipeptide NZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptide NZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptide NZ_LR594050.1 Lanthipeptides: FGL20_RS03485_lanthipeptide NZ_SSXN01000004.1 Lanthipeptides: FAJ36_RS04715_lanthipeptide
Lanthipeptides: SGPB_RS10680_lanthipeptide
1
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C H
29
+T S L C T P G C T G L M C K T T C C H
1
V T S K S L C T P G C K T G I L M T C A I K T A T C G C H
29
48.7%
NC_022237.1 and 1 other:
NZ_JUZI01000019.1 Lanthipeptides: ADI02_RS09325_lanthipeptide
Lanthipeptides: SII_RS05025_lanthipeptide
1
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C H
29
+T S +C T P G C+T G L M G C N +T T C+C H
1
V T S V F M C T P G C V T G A L M G C N L Q T A T C N C H
29

#### MIBiG 4.0 matches for FF306_RS00060

56.4%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
1
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C
28
I T S L C T P G C T G L M G C N K T T C H C
1
I T S I S L C T P G C K T G A L M G C N M K T A T C H C
28

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.97 out of 29.38
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.07 out of 24.78
Confidence: medium
Additional weak hits (1):
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.70 out of 27.55
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

FF306_RS00060 - Class I
  Cleavage pHMM score: 9.10
  RODEO score: 17
  Monoisotopic mass: 4162.0 Da
  Molecular weight: 4164.8 Da
  Number of bridges: 5
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4182.8 Da N = 1
    4200.8 Da N = 2
    4218.8 Da N = 3
    4236.9 Da N = 4

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
FuR variant 1 | Ferric Uptake Regulator
LexA variant 2 | Repressor of DNA damage response

NZ_BDDX01000012.1 - Region 1 - lanthipeptide-class-i
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 19,484 nt. (total: 19,484 nt) Show pHMM detection rules used
Region on contig edge.
lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: protease
FF306_RS05505: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase dehydratase
FF306_RS05515: Lanthionine synthetase C family protein

smcogs
  SMCOG1140: Lanthionine synthetase C family protein

FF306_RS05540: Lantibiotic dehydratase domain protein

smcogs
  SMCOG1155: Lantibiotic dehydratase domain protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-i | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000538.3 |  | 0.55 | ribosomal | nisin Z | Lactococcus lactis
BGC0000542.3 |  | 0.51 | ribosomal | paenicidin B | Paenibacillus terrae
BGC0000556.5 |  | 0.50 | ribosomal | streptin | Streptococcus pyogenes
BGC0002323.2 |  | 0.50 | ribosomal | nisin J | Staphylococcus capitis
BGC0000506.4 |  | 0.48 | ribosomal | entianin | Bacillus subtilis subsp. spizizenii
BGC0001618.3 |  | 0.48 | ribosomal | hyicin 3682 | Staphylococcus hyicus
BGC0002635.2 |  | 0.47 | ribosomal | daspyromycin A, daspyromycin B | Actinokineospora diospyrosa
BGC0001210.5 |  | 0.47 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000541.5 |  | 0.47 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0000539.5 |  | 0.46 | ribosomal | nukacin ISK-1 | Staphylococcus warneri

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000538.3 |  | 0.55 | ribosomal | nisin Z | Lactococcus lactis
BGC0000542.3 |  | 0.51 | ribosomal | paenicidin B | Paenibacillus terrae
BGC0000556.5 |  | 0.50 | ribosomal | streptin | Streptococcus pyogenes
BGC0002323.2 |  | 0.50 | ribosomal | nisin J | Staphylococcus capitis
BGC0000506.4 |  | 0.48 | ribosomal | entianin | Bacillus subtilis subsp. spizizenii
BGC0001618.3 |  | 0.48 | ribosomal | hyicin 3682 | Staphylococcus hyicus
BGC0002635.2 |  | 0.47 | ribosomal | daspyromycin A, daspyromycin B | Actinokineospora diospyrosa
BGC0001210.5 |  | 0.47 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000541.5 |  | 0.47 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0000539.5 |  | 0.46 | ribosomal | nukacin ISK-1 | Staphylococcus warneri

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for FF306_RS05540

FF306_RS05510
Leader:
MEVIDMSNFNDFNLGIKKVHSGSKKGLEPR
Core:
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C H S S N H F S F H A R
Core with dehydrations:
I Dhb Dha Y V L Cys Dhb P G Cys I Dhb G R L M G Cys N N K Dhb K Dhb Cys H Cys H Dha Dha N H F Dha F H A R

#### antiSMASH-DB 4.0 matches for FF306_RS05510

100.0%
NZ_AP019008.1 and 1 other:
NZ_BDDX01000012.1 Lanthipeptides: FF306_RS05510_lanthipeptide
Lanthipeptides: FF306_RS00060_lanthipeptide
1
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C H S S N H F S F H A R
39
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C H S S N H F S F H A R
1
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C H S S N H F S F H A R
39
94.9%
NZ_JXCW01000008.1:
Lanthipeptides: RZ55_RS07215_lanthipeptide
1
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C H S S N H F S F H A R
39
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C H S S++F S F H A R
1
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C H S S H N F S F H A R
39
56.4%
NZ_CP065984.1 and 2 others:
NZ_CP095737.1 Lanthipeptides: MXM90_RS03205_lanthipeptide NZ_JAQDXJ010000021.1 Lanthipeptides: PGU19_RS11740_lanthipeptide
Lanthipeptides: I6I21_RS02785_lanthipeptide
1
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C
28
I T S L C T P G C T G L M G C N K T T C H C
1
I T S I S L C T P G C K T G A L M G C N M K T A T C H C
28
with 117 more sequence matches
Only the first 10 are displayed here.
56.4%
NZ_FNDP01000013.1:
Lanthipeptides: BLP54_RS11230_lanthipeptide
1
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C
28
I T S L C T P G C+T G L M G C N N K T T C+C
3
I T S K S L C T P G C V T G V L M G C N N K T A T C N C
30
53.8%
NC_013656.1 and 20 others:
NC_020450.1 Lanthipeptides: LILO_RS03015_lanthipeptide NZ_CP009472.1 Lanthipeptides: LG36_RS03420_lanthipeptide NZ_CP010050.1 Lanthipeptides: QI18_RS03300_lanthipeptide NZ_CP015903.1 Lanthipeptides: LLUC08_RS03255_lanthipeptide NZ_CP024954.1 Lanthipeptides: CV702_RS02990_lanthipeptide NZ_CP066300.1 Lanthipeptides: LacL0098_RS03205_lanthipeptide NZ_CP098790.1 Lanthipeptides: M5C73_RS03405_lanthipeptide NZ_JAALEQ010000006.1 Lanthipeptides: HFD15_RS10120_lanthipeptide NZ_JAJONJ010000005.1 Lanthipeptides: LSG16_RS07195_lanthipeptide NZ_JAQDWM010000007.1 Lanthipeptides: PGU01_RS08180_lanthipeptide NZ_JAQDXV010000018.1 Lanthipeptides: PGT80_RS11850_lanthipeptide NZ_JAQDYA010000007.1 Lanthipeptides: PGT72_RS09560_lanthipeptide NZ_JAQDYA010000007.1 Lanthipeptides: PGT72_RS09560_lanthipeptide NZ_JAQEIZ010000019.1 Lanthipeptides: PGX18_RS12025_lanthipeptide NZ_JAQEOU010000022.1 Lanthipeptides: PGV42_RS12330_lanthipeptide NZ_JAQEOV010000015.1 Lanthipeptides: PGW09_RS10765_lanthipeptide NZ_MTJP01000006.1 Lanthipeptides: BW151_RS03795_lanthipeptide NZ_MTJR01000005.1 Lanthipeptides: BW153_RS02980_lanthipeptide NZ_MTJS01000002.1 Lanthipeptides: BW154_RS09850_lanthipeptide NZ_RAGL01000022.1 Lanthipeptides: D6108_RS11395_lanthipeptide
Lanthipeptides: LLKF_RS13210_lanthipeptide
1
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C
28
I T S L C T P G C T G L M G C N K T T C+C
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C
28
53.8%
NZ_CP059471.1 and 3 others:
NZ_FNZW01000001.1 Lanthipeptides: BMZ61_RS02110_lanthipeptide NZ_FOYC01000001.1 Lanthipeptides: BMZ88_RS03370_lanthipeptide NZ_KE384124.1 Lanthipeptides: G597_RS0106700_lanthipeptide
Lanthipeptides: H1R75_RS06635_lanthipeptide
1
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C H S S N
32
I T S L C T P G C T G L M C K T T C C H N
1
I T S K S L C T P G C K T G A L M T C P I K T A T C G C H F G N
32
53.8%
NZ_CP090412.1 and 3 others:
NZ_QSTB01000004.1 Lanthipeptides: DXC22_RS03785_lanthipeptide NZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptide NZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptide
Lanthipeptides: LZF92_RS09890_lanthipeptide
1
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C H
29
I T S Y L C T P G C T G L M G C K T +C C H
1
I T S Y S L C T P G C K T G A L M G C T M K T A S C G C H
29
53.8%
NZ_FBTD01000003.1:
Lanthipeptides: PB1E_RS03075_lanthipeptide
1
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C H
29
I T S L C T P G C T G L M G C N K T +C C H
1
I T S V S L C T P G C K T G A L M G C N M K T A S C G C H
29
51.3%
NZ_CP013655.1 and 2 others:
NZ_CP013655.1 Lanthipeptides: ATZ35_RS03635_lanthipeptide NZ_CP013655.1 Lanthipeptides: ATZ35_RS03630_lanthipeptide
Lanthipeptides: ATZ35_RS03640_lanthipeptide
1
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C H
29
I T S L C T P G C+T G L M G C K T T C+C
1
I T S K S L C T P G C V T G V L M G C A L K T I T C N C S
29
51.3%
NZ_JADNFO010000025.1:
Lanthipeptides: I2C89_RS09745_lanthipeptide
1
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C
28
I T S Y L C T P G C T G L M C+ K T T C+C
1
I T S Y S L C T P G C K T G V L M A C H L K T A T C N C
28
51.3%
NZ_LR793265.1:
Lanthipeptides: HV392_RS09825_lanthipeptide
1
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C H
29
I T S Y L C T P G C I T G R L M G C ++ C+ H
1
I T S Y S L C T P G C I T G R L M G C Q F Q S A G C N V H
29
48.7%
NC_015600.1 and 14 others:
NZ_AP020310.1 Lanthipeptides: SAGCMC97051_RS07300_lanthipeptide NZ_ATVP01000001.1 Lanthipeptides: G574_RS11150_lanthipeptide NZ_BCFB01000042.1 Lanthipeptides: GOZ36_RS07980_lanthipeptide NZ_CP068708.1 Lanthipeptides: JM964_RS04040_lanthipeptide NZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptide NZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptide NZ_FIKS01000005.1 Lanthipeptides: A0525_RS10015_lanthipeptide NZ_GL636070.1 Lanthipeptides: HMPREF9171_RS106200_lanthipeptide NZ_JADPLU010000018.1 Lanthipeptides: I4V82_RS09545_lanthipeptide NZ_JAKVIE010000017.1 Lanthipeptides: MK857_RS08340_lanthipeptide NZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptide NZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptide NZ_LR594050.1 Lanthipeptides: FGL20_RS03485_lanthipeptide NZ_SSXN01000004.1 Lanthipeptides: FAJ36_RS04715_lanthipeptide
Lanthipeptides: SGPB_RS10680_lanthipeptide
1
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C H
29
+T S L C T P G C T G L M C K T T C C H
1
V T S K S L C T P G C K T G I L M T C A I K T A T C G C H
29
48.7%
NC_022237.1 and 1 other:
NZ_JUZI01000019.1 Lanthipeptides: ADI02_RS09325_lanthipeptide
Lanthipeptides: SII_RS05025_lanthipeptide
1
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C H
29
+T S +C T P G C+T G L M G C N +T T C+C H
1
V T S V F M C T P G C V T G A L M G C N L Q T A T C N C H
29

#### MIBiG 4.0 matches for FF306_RS05510

56.4%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
1
I T S Y V L C T P G C I T G R L M G C N N K T K T C H C
28
I T S L C T P G C T G L M G C N K T T C H C
1
I T S I S L C T P G C K T G A L M G C N M K T A T C H C
28

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.97 out of 29.38
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.07 out of 24.78
Confidence: medium
Additional weak hits (1):
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.70 out of 27.55
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

FF306_RS05510 - Class I
  Cleavage pHMM score: 9.10
  RODEO score: 17
  Monoisotopic mass: 4162.0 Da
  Molecular weight: 4164.8 Da
  Number of bridges: 5
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4182.8 Da N = 1
    4200.8 Da N = 2
    4218.8 Da N = 3
    4236.9 Da N = 4

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
FuR variant 1 | Ferric Uptake Regulator
LexA variant 2 | Repressor of DNA damage response

NZ_BDDX01000016.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 120,919 - 141,132 nt. (total: 20,214 nt) Show pHMM detection rules used
Region on contig edge.
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: formyltransferase
FF306_RS07095: methionyl-tRNA formyltransferase

smcogs
  SMCOG1228: methionyl-tRNA formyltransferase

Ligases: synthetase
FF306_RS07130: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0001605.3 |  | 0.38 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000678.5 |  | 0.36 | terpene | pentalenolactone | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000531.3 |  | 0.35 | ribosomal | mutacin I | Streptococcus mutans
BGC0000665.5 |  | 0.35 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0000533.3 |  | 0.34 | ribosomal | mutacin III | Streptococcus mutans

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0001605.3 |  | 0.38 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000678.5 |  | 0.36 | terpene | pentalenolactone | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000531.3 |  | 0.35 | ribosomal | mutacin I | Streptococcus mutans
BGC0000665.5 |  | 0.35 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0000533.3 |  | 0.34 | ribosomal | mutacin III | Streptococcus mutans

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
FF306_RS07130: PT_FPPS_like
Domain 1 (35 - 290): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  IPP, DMAPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 25.53 out of 30.25
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.95 out of 28.19
Confidence: medium
Additional weak hits (3):
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.23 out of 26.85
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 24.22 out of 35.63
Confidence: weak
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.87 out of 18.46
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ColR | Phenol-responsive regulator
ZuR variant 1 | Zinc-responsive repressor