GCF_001811455.1 - 6 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_KV804811.1 (Rothia sp. HMSC065G12)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 15.1	butyrolactone	31,697	47,557	Low	branched-chain fatty acids	other:other
Region 15.2	azole-containing-RiPP	72,335	94,579

NZ_KV804813.1 (Rothia sp. HMSC065G12)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 16.1	azole-containing-RiPP	62,824	86,352

NZ_KV804815.1 (Rothia sp. HMSC065G12)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 18.1	terpene-precursor	42,608	63,750
Region 18.2	NRPS	657,923	702,155	High	enterobactin	NRPS:Type I

NZ_KV804818.1 (Rothia sp. HMSC065G12)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 19.1	lanthipeptide-class-ii,linaridin	81,736	131,908

No secondary metabolite regions were found in these records:: NZ_KV804792.1 (Rothia sp. HMSC065G12); NZ_KV804794.1 (Rothia sp. HMSC065G12); NZ_KV804795.1 (Rothia sp. HMSC065G12); NZ_KV804796.1 (Rothia sp. HMSC065G12); NZ_KV804797.1 (Rothia sp. HMSC065G12); NZ_KV804799.1 (Rothia sp. HMSC065G12); NZ_KV804800.1 (Rothia sp. HMSC065G12); NZ_KV804801.1 (Rothia sp. HMSC065G12); NZ_KV804803.1 (Rothia sp. HMSC065G12); NZ_KV804804.1 (Rothia sp. HMSC065G12); NZ_KV804805.1 (Rothia sp. HMSC065G12); NZ_KV804806.1 (Rothia sp. HMSC065G12); NZ_KV804807.1 (Rothia sp. HMSC065G12); NZ_KV804808.1 (Rothia sp. HMSC065G12); NZ_KV804814.1 (Rothia sp. HMSC065G12); NZ_KV804819.1 (Rothia sp. HMSC065G12); NZ_KV804820.1 (Rothia sp. HMSC065G12)

Compact view

NZ_KV804811.1 - Region 1 - butyrolactone

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Location: 31,697 - 47,557 nt. (total: 15,861 nt) Show pHMM detection rules used

butyrolactone: AfsA

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

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MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

HMPREF2804_RS02695: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Ligases: ligase synthase

HMPREF2804_RS02665: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

HMPREF2804_RS02675: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

HMPREF2804_RS02685: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

HMPREF2804_RS02725: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001535.3	0.70	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001534.3	0.63	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001164.3	0.58	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001641.4	0.58	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002711.2	0.54	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0001987.2	0.51	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis
BGC0001197.5	0.50	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000866.5	0.50	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0001723.5	0.49	PKS	oviedomycin	Streptomyces antibioticus
BGC0000234.5	0.48	PKS	jadomycin	Streptomyces venezuelae ATCC 10712

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001535.3	0.70	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001534.3	0.63	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001164.3	0.58	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001641.4	0.58	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002711.2	0.54	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0001987.2	0.51	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis
BGC0001197.5	0.50	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000866.5	0.50	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0001723.5	0.49	PKS	oviedomycin	Streptomyces antibioticus
BGC0000234.5	0.48	PKS	jadomycin	Streptomyces venezuelae ATCC 10712

Similar known clusters from MIBiG 4.0

Similar subclusters

Transcription Factor Binding Sites

Binding sites found:

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.70 out of 29.25

Confidence: medium

Additional weak hits (9):

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.94 out of 19.52

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.66 out of 29.38

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.08 out of 31.73

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 17.37 out of 28.14

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.88 out of 27.78

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 20.42 out of 33.73

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 19.83 out of 31.73

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.18 out of 29.38

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.10 out of 26.06

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
SypG	Regulator of biofilm formation and host colonization

NZ_KV804811.1 - Region 2 - azole-containing-RiPP

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Location: 72,335 - 94,579 nt. (total: 22,245 nt) Show pHMM detection rules used

azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Azole RiPPs

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase synthase

HMPREF2804_RS02840: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

HMPREF2804_RS02940: riboflavin biosynthesis protein RibD

smcogs: SMCOG1240: riboflavin biosynthesis protein RibD

Hydrolases: synthase

HMPREF2804_RS02940: riboflavin biosynthesis protein RibD

smcogs: SMCOG1240: riboflavin biosynthesis protein RibD

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001174.4	0.51	ribosomal	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0000569.5	0.50	ribosomal	plantazolicin	Bacillus velezensis FZB42
BGC0001173.5	0.50	ribosomal	plantazolicin	Bacillus pumilus ATCC 7061
BGC0002144.3	0.47	ribosomal	phazolicin	Rhizobium sp. Pop5
BGC0000568.5	0.47	ribosomal	microcin B17	Escherichia coli
BGC0002013.4	0.46	ribosomal	curacozole	Streptomyces curacoi
BGC0002115.3	0.43	ribosomal	streptamidine	Streptomyces albidoflavus J1074
BGC0000560.5	0.40	ribosomal	subtilomycin	Bacillus subtilis
BGC0002515.2	0.39	PKS	solanapyrone A	Ascochyta rabiei
BGC0002701.2	0.39	ribosomal	paenithipeptin	Paenibacillus thiaminolyticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001174.4	0.51	ribosomal	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0000569.5	0.50	ribosomal	plantazolicin	Bacillus velezensis FZB42
BGC0001173.5	0.50	ribosomal	plantazolicin	Bacillus pumilus ATCC 7061
BGC0002144.3	0.47	ribosomal	phazolicin	Rhizobium sp. Pop5
BGC0000568.5	0.47	ribosomal	microcin B17	Escherichia coli
BGC0002013.4	0.46	ribosomal	curacozole	Streptomyces curacoi
BGC0002115.3	0.43	ribosomal	streptamidine	Streptomyces albidoflavus J1074
BGC0000560.5	0.40	ribosomal	subtilomycin	Bacillus subtilis
BGC0002515.2	0.39	PKS	solanapyrone A	Ascochyta rabiei
BGC0002701.2	0.39	ribosomal	paenithipeptin	Paenibacillus thiaminolyticus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.93 out of 30.25

Confidence: medium

Additional weak hits (8):

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.15 out of 21.55

Confidence: weak

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.49 out of 29.72

Confidence: weak

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.60 out of 29.51

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.44 out of 26.06

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.48 out of 30.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.52 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.66 out of 26.06

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 21.52 out of 33.14

Confidence: weak

(Thi)azol(in)e containing peptide predictions

No core peptides found.

TFBS Finder

Azole RiPPs

TFBS definitions

Regulator	Description
ColR	Phenol-responsive regulator

Core peptide predictions

No core peptides found.

NZ_KV804813.1 - Region 1 - azole-containing-RiPP

Download region GenBank file

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Location: 62,824 - 86,352 nt. (total: 23,529 nt) Show pHMM detection rules used

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Azole RiPPs

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase oxygenase

HMPREF2804_RS03330: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

HMPREF2804_RS03340: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002584.2	0.44	ribosomal	azolemycin B, azolemycin A, azolemycin D, azolemycin C	Streptomyces sp. FXJ1.264
BGC0000528.5	0.44	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001849.4	0.44	ribosomal	thiovarsolin A, thiovarsolin B, thiovarsolin C, thiovarsolin D	Streptomyces varsoviensis
BGC0001226.4	0.42	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0000563.4	0.42	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0002707.2	0.42	terpene	(+)-δ-cadinol	Coniophora puteana RWD-64-598 SS2
BGC0002551.2	0.41	other (other), ribosomal, terpene	muscoride A, muscoride B	Nostoc sp. UHCC-0398
BGC0000569.5	0.41	ribosomal	plantazolicin	Bacillus velezensis FZB42
BGC0001173.5	0.41	ribosomal	plantazolicin	Bacillus pumilus ATCC 7061
BGC0002485.2	0.41	other (other), ribosomal	muscoride A, muscoride B	Desmonostoc sp. PCC 7906

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002584.2	0.44	ribosomal	azolemycin B, azolemycin A, azolemycin D, azolemycin C	Streptomyces sp. FXJ1.264
BGC0000528.5	0.44	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001849.4	0.44	ribosomal	thiovarsolin A, thiovarsolin B, thiovarsolin C, thiovarsolin D	Streptomyces varsoviensis
BGC0001226.4	0.42	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0000563.4	0.42	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0002707.2	0.42	terpene	(+)-δ-cadinol	Coniophora puteana RWD-64-598 SS2
BGC0002551.2	0.41	other (other), ribosomal, terpene	muscoride A, muscoride B	Nostoc sp. UHCC-0398
BGC0000569.5	0.41	ribosomal	plantazolicin	Bacillus velezensis FZB42
BGC0001173.5	0.41	ribosomal	plantazolicin	Bacillus pumilus ATCC 7061
BGC0002485.2	0.41	other (other), ribosomal	muscoride A, muscoride B	Desmonostoc sp. PCC 7906

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.87 out of 27.78

Confidence: medium

Additional weak hits (7):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 20.53 out of 30.25

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.60 out of 26.12

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 21.41 out of 33.73

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.31 out of 35.63

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.33 out of 33.14

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.92 out of 30.11

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.24 out of 29.25

Confidence: weak

(Thi)azol(in)e containing peptide predictions

No core peptides found.

TFBS Finder

Azole RiPPs

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria

Core peptide predictions

No core peptides found.

NZ_KV804815.1 - Region 1 - terpene-precursor

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Location: 42,608 - 63,750 nt. (total: 21,143 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

HMPREF2804_RS05500: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: acyltransferase

HMPREF2804_RS05515: acyltransferase

smcogs: SMCOG1141: acyltransferase

Ligases: ligase synthetase

HMPREF2804_RS05505: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

HMPREF2804_RS05535: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002193.2	0.56	other (other)	phenguignardic acid	Aspergillus terreus NIH2624
BGC0000677.5	0.42	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0002561.3	0.40	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000649.3	0.40	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000597.4	0.40	ribosomal	SWA-2138	Streptomyces sp. e14
BGC0001910.4	0.39	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0000595.3	0.39	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)
BGC0001456.3	0.38	terpene	isorenieratene	Streptomyces argillaceus
BGC0000664.5	0.38	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001911.3	0.38	terpene	raimonol	Streptomyces anulatus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002193.2	0.56	other (other)	phenguignardic acid	Aspergillus terreus NIH2624
BGC0000677.5	0.42	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0002561.3	0.40	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000649.3	0.40	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000597.4	0.40	ribosomal	SWA-2138	Streptomyces sp. e14
BGC0001910.4	0.39	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0000595.3	0.39	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)
BGC0001456.3	0.38	terpene	isorenieratene	Streptomyces argillaceus
BGC0000664.5	0.38	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001911.3	0.38	terpene	raimonol	Streptomyces anulatus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

HMPREF2804_RS05535: PT_FPPS_like

Domain 1 (58 - 371): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (3):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 20.40 out of 28.14

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.87 out of 32.93

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.07 out of 36.54

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description

NZ_KV804815.1 - Region 2 - NRPS

Download region GenBank file

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Location: 657,923 - 702,155 nt. (total: 44,233 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

HMPREF2804_RS08060: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

Transferases: formyltransferase transketolase

HMPREF2804_RS08070: transketolase

smcogs: SMCOG1204: transketolase

HMPREF2804_RS08155: methionyl-tRNA formyltransferase

smcogs: SMCOG1228: methionyl-tRNA formyltransferase

Hydrolases: deformylase esterase

HMPREF2804_RS08100: enterobactin/ferric enterobactin esterase

smcogs: SMCOG1098: enterobactin/ferric enterobactin esterase

HMPREF2804_RS08160: peptide deformylase

smcogs: SMCOG1275: peptide deformylase

Ligases: ligase synthase

HMPREF2804_RS08050: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

HMPREF2804_RS08085: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

HMPREF2804_RS08095: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002685.2	0.74	NRPS	enterobactin	Rothia mucilaginosa ATCC 25296
BGC0001825.4	0.66	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001641.4	0.63	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.63	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001261.3	0.63	NRPS	AM-toxin	Alternaria alternata
BGC0000357.5	0.63	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001251.4	0.62	NRPS	epichloenin A	Epichloe festucae
BGC0001250.4	0.62	NRPS	epichloenin A	Epichloe festucae
BGC0001240.4	0.62	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0000342.4	0.62	NRPS	enniatin	Fusarium equiseti

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002685.2	0.74	NRPS	enterobactin	Rothia mucilaginosa ATCC 25296
BGC0001825.4	0.66	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001641.4	0.63	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.63	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001261.3	0.63	NRPS	AM-toxin	Alternaria alternata
BGC0000357.5	0.63	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001251.4	0.62	NRPS	epichloenin A	Epichloe festucae
BGC0001250.4	0.62	NRPS	epichloenin A	Epichloe festucae
BGC0001240.4	0.62	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0000342.4	0.62	NRPS	enniatin	Fusarium equiseti

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.59 out of 27.78

Confidence: medium

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.89 out of 29.72

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.10 out of 23.79

Confidence: medium

Additional weak hits (13):

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.12 out of 21.84

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 21.31 out of 30.97

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.68 out of 21.55

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.39 out of 24.78

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.79 out of 22.40

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.45 out of 29.25

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.42 out of 36.53

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.08 out of 26.06

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.38 out of 21.84

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.00 out of 26.06

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.88 out of 26.12

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.10 out of 30.98

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 25.12 out of 36.53

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 2, location 657922 - 702155:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ser)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

HMPREF2804_RS08085: Ser

Search NORINE for peptide: strict or relaxed

AMP-binding (520..959): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWQTFDVHVWEWHFICSGELNLYGPTEAAVDVTF
Nearest Stachelhaus code(s):: Ser DVWHISLVDK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

HMPREF2804_RS08095: diOH-Bz

Search NORINE for peptide: strict or relaxed

AMP-binding (54..466): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: SGSLFTMSSPGGSLQVGGSQQVFGMAEGLVNYTR
Nearest Stachelhaus code(s):: diOH-Bz TMPSQGVVNK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
IolR	Regulator of the inositol catabolism
NtrC	Nitrogen regulatory protein C

NZ_KV804818.1 - Region 1 - lanthipeptide-class-ii,linaridin

Download region GenBank file

Download region SVG

Location: 81,736 - 131,908 nt. (total: 50,173 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)
linaridin: (cypemycin or cypI)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

HMPREF2804_RS09495: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

HMPREF2804_RS09510: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

HMPREF2804_RS09520: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

Lyases: cyclase

HMPREF2804_RS09425: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

HMPREF2804_RS09470: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

HMPREF2804_RS09490: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001229.4	0.53	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0002110.3	0.46	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000583.5	0.44	ribosomal	grisemycin	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002698.2	0.43	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002319.3	0.43	ribosomal	salinipeptin A, salinipeptin B, salinipeptin C, salinipeptin D	Streptomyces sp.
BGC0000582.4	0.39	ribosomal	cypemycin	Streptomyces sp. OH-4156
BGC0001555.4	0.39	ribosomal	colicin V	Escherichia coli chi7122
BGC0001201.3	0.39	terpene	eremophilene	Sorangium cellulosum So ce56
BGC0000497.3	0.38	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0000554.4	0.38	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001229.4	0.61	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0002110.3	0.58	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0002698.2	0.57	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000583.5	0.55	ribosomal	grisemycin	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000497.3	0.54	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0002319.3	0.54	ribosomal	salinipeptin A, salinipeptin B, salinipeptin C, salinipeptin D	Streptomyces sp.
BGC0000623.3	0.53	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000582.4	0.52	ribosomal	cypemycin	Streptomyces sp. OH-4156
BGC0001555.4	0.52	ribosomal	colicin V	Escherichia coli chi7122
BGC0001201.3	0.51	terpene	eremophilene	Sorangium cellulosum So ce56

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for HMPREF2804_RS09425

HMPREF2804_RS11135

Leader:

MDSISLIAEVSDQELAGT

Core:

VGDQAGGLFTVPGTTTVGHFCTISWECSGFICGK

Core with dehydrations:

VGDQAGGLFDhbVPGDhbDhbDhbVGHFCysDhbIDhaWECysDhaGFICysGK

antiSMASH-DB 4.0 matches for HMPREF2804_RS11135

100.0%

NC_014643.1and 2 others:

NZ_KV795763.1 Lanthipeptides: HMPREF2554_RS11600_lanthipeptideNZ_KV804818.1 Lanthipeptides: HMPREF2804_RS11135_lanthipeptide

Lanthipeptides: HMPREF0733_RS11155_lanthipeptide

VGDQAGGLFTVPGTTTVGHFCTISWECSGFICGK

72.2%

NZ_JAPVBQ010000001.1:

Lanthipeptides: O2V63_RS05740_lanthipeptide

VGDQAGGLFTVPGTTTVGHFCTISWECSGFICG

VGDQAGGLFT T TVG CTISWECSG ICG

VGDQAGGLFTFKTTKTVGAVCTISWECSGRICG

55.9%

NZ_CP051884.1and 2 others:

NZ_CP051884.1 Lanthipeptides: HGK68_RS15160_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15160_lanthipeptide

Lanthipeptides: HGK68_RS15160_lanthipeptide

QAGGLFTVPGTTTVGHFCTISWECSGFICGK

+AGG++T+PGT T+G FCTIS+EC GF+C

RAGGIWTIPGTKTIGAFCTISYECWGFVCNN

with 52 more sequence matches

Only the first 10 are displayed here.

55.9%

NZ_LR027842.1:

Lanthipeptides: E0E39_RS15855_lanthipeptide

LFTVPGTTTVGHFCTISWECSGFICG

L+TVPGT T+G CT+SWEC GFICG

LWTVPGTRTIGAVCTVSWECHGFICG

50.0%

NZ_CP035495.1and 1 other:

NZ_CP035495.1 Lanthipeptides: ET495_RS17535_lanthipeptide

Lanthipeptides: ET495_RS17535_lanthipeptide

LFTVPGTTTVGHFCTISWECSGFICG

L+T+PGT+T+G FCT+SWEC G CG

LWTIPGTSTIGRFCTLSWECQGIACG

44.1%

NZ_PVMZ01000043.1and 1 other:

NZ_PVMZ01000043.1 Lanthipeptides: CLV67_RS49720_lanthipeptide

Lanthipeptides: CLV67_RS49720_lanthipeptide

LFTVPGTTTVGHFCTISWECS

LFTVPGT+T+G+ CT S+ECS

LFTVPGTSTIGYVCTYSYECS

44.1%

NZ_QGGR01000002.1:

Lanthipeptides: BC793_RS05490_lanthipeptide

LFTVPGTTTVGHFCTISWECS

L+TVPGT+T+G CT+SWECS

LYTVPGTSTIGWICTVSWECS

38.2%

NZ_CP025227.1:

Lanthipeptides: allorf_0999194_0999376_lanthipeptide

LFTVPGTTTVGHFCTISWECS

L+TVP T+T+G CT+SWEC+

LWTVPTTSTIGLVCTLSWECT

29.4%

NC_017912.1and 14 others:

NZ_CP007242.1 Lanthipeptides: KHU1_RS17410_lanthipeptideNZ_CP031424.1 Lanthipeptides: DXX91_RS18935_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS10440_lanthipeptideNZ_CP043809.1 Lanthipeptides: ETZ92_RS14260_lanthipeptideNZ_CP049904.1 Lanthipeptides: V753_RS18470_lanthipeptideNZ_CP053764.1 Lanthipeptides: HPQ66_RS18325_lanthipeptideNZ_CP061938.1 Lanthipeptides: IEN91_RS19800_lanthipeptideNZ_CP063768.1 Lanthipeptides: IM712_RS05205_lanthipeptideNZ_CP087137.1 Lanthipeptides: LOK79_RS18580_lanthipeptideNZ_CP092383.1 Lanthipeptides: MID02_RS19390_lanthipeptideNZ_JAEACM010000001.1 Lanthipeptides: I5F15_RS04355_lanthipeptideNZ_JAJNPN010000015.1 Lanthipeptides: LQ568_RS13285_lanthipeptideNZ_SDKF01000002.1 Lanthipeptides: EUA41_RS09950_lanthipeptideNZ_VDUT01000007.1 Lanthipeptides: FS412_RS14545_lanthipeptide

Lanthipeptides: MUS_RS20065_lanthipeptide

QAGGLFTVPGTTTVGHFCTISWEC

+A FT+PG G CT++ EC

EAACTFTLPGG---GGVCTLTSEC

29.4%

NZ_AP024169.1:

Lanthipeptides: bsdtb5_RS06110_lanthipeptide

GHFCTISWEC--SGFICGK

G F TIS+EC + CGK

GGFPTISYECTSNNVSCGK

27.0%

NZ_CP048273.1and 1 other:

NZ_CP048273.1 Lanthipeptides: M654_RS18500_lanthipeptide

Lanthipeptides: M654_RS18500_lanthipeptide

GHFCTISWECSGFI-CGK

G +CT S EC+G + CGK

GKYCTWSAECAGTVSCGK

26.5%

NZ_AP024169.1:

Lanthipeptides: bsdtb5_RS06105_lanthipeptide

GHFCTISWEC--SGFICGK

G TIS+EC + CGK

GRMPTISYECTSNNVSCGK

26.5%

NZ_AUBN01000022.1:

Lanthipeptides: G448_RS16025_lanthipeptide

GHFCTISWECSGFICG

G FCT++ EC FIC

GWFCTLTIECGTFICA

MIBiG 4.0 matches for HMPREF2804_RS11135

14.7%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

GHFCTISWEC

G +CT++ EC

GAYCTLTVEC

14.7%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

GHFCTISWEC

G +CT++ EC

GGWCTLTKEC

12.8%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

CTISWEC

CT+S EC

CTLSKEC

HMPREF2804_RS09455

Leader:

MAQNDHQDKHPKRKEIPSSLWVFALATFVLALPRIGDGRILPLDLTTSFILGA

Core:

VLIVCGFWMMYREHKKSSAQKK

Core with dehydrations:

VLIVCysGFWMMYREHKKDhaDhaAQKK

antiSMASH-DB 4.0 matches for HMPREF2804_RS09455

100.0%

NZ_JVXR01000038.1and 6 others:

NZ_KV793075.1 Lanthipeptides: HMPREF3164_RS06965_lanthipeptideNZ_KV797630.1 Lanthipeptides: HMPREF2609_RS05985_lanthipeptideNZ_KV804818.1 Lanthipeptides: HMPREF2804_RS09455_lanthipeptideNZ_KV804818.1 Lanthipeptides: HMPREF2804_RS09455_lanthipeptideNZ_KV804818.1 Lanthipeptides: HMPREF2804_RS09455_lanthipeptideNZ_KV817389.1 Lanthipeptides: HMPREF2981_RS04655_lanthipeptide

Lanthipeptides: ADK06_RS05035_lanthipeptide

VLIVCGFWMMYREHKKSSAQKK

26.9%

NZ_KZ268499.1:

Lanthipeptides: allorf_4452434_4452649_lanthipeptide

VCGFWMMYREHKKSSA

+CG R H KSS+

LCGLCTFIRAHPKSSS

20.0%

NZ_CP066762.1:

Lanthipeptides: JG536_RS12630_lanthipeptide

IVCG--FWMMYREHKKSS

IV G MM+R+HK S

IVIGALLAMMHRKHKYSP

with 1 more sequence matches

18.2%

NZ_QPIX01000013.1:

Lanthipeptides: allorf_114776_114868_lanthipeptide

LIVCGFWMMYREH

L+ C W+ Y+++

LLACSHWLRYKDN

allorf_083218_083325

Leader:

MGRGMHEPIAG

Core:

VQRMRFLTLCEQATHDIFQIQNIY

Core with dehydrations:

VQRMRFLDhbLCysEQADhbHDIFQIQNIY

antiSMASH-DB 4.0 matches for allorf_083218_083325

24.2%

NZ_CP077072.1:

Lanthipeptides: allorf_2268889_2269032_lanthipeptide

QRMRFLTLCEQATHDIFQIQNIY

RMR +L A H I Q ++

HRMRRRSLVRLACHRIHQDGPVH

9.8%

NC_002935.2and 6 others:

NC_016787.1 Lanthipeptides: allorf_0700263_0700493_lanthipeptideNC_016788.1 Lanthipeptides: allorf_0708439_0708669_lanthipeptideNC_016790.1 Lanthipeptides: allorf_0677571_0677801_lanthipeptideNZ_CP038504.1 Lanthipeptides: allorf_0571829_0572059_lanthipeptideNZ_CP040557.1 Lanthipeptides: allorf_0667863_0668093_lanthipeptideNZ_MIOB01000009.1 Lanthipeptides: allorf_00076_00306_lanthipeptide

Lanthipeptides: allorf_0739982_0740212_lanthipeptide

TLCEQATHDIFQIQNI

+ C Q + D+F+ Q+I

SWCGQISPDVFEAQSI

allorf_096778_096948

Leader:

MTILEHIRQA

Core:

TCDTCSYVEYIIVSDFYIQVNISSSPKANFMGYLTILLTLCCIPSE

Core with dehydrations:

DhbCysDDhbCysDhaYVEYIIVDhaDFYIQVNIDhaDhaDhaPKANFMGYLDhbILLDhbLCysCysIPDhaE

antiSMASH-DB 4.0 matches for allorf_096778_096948

100.0%

NC_014643.1and 1 other:

NZ_KV804818.1 Lanthipeptides: allorf_096778_096948_lanthipeptide

Lanthipeptides: allorf_1155122_1155292_lanthipeptide

TCDTCSYVEYIIVSDFYIQVNISSSPKANFMGYLTILLTLCCIPSE

26.1%

NZ_JAOQJV010000004.1:

Lanthipeptides: OCV65_RS05205_lanthipeptide

EYIIVSDFYIQVNISSSPKANFMGYLTILLTLCC

EY ++ D QV + ++ N G+LTI +CC

EYNMLMDEAEQVVVYATQSGNCSGFLTI---ICC

23.9%

NZ_CP013979.1:

Lanthipeptides: allorf_0343557_0343787_lanthipeptide

IQVNIS---SSPKANFMGYLTILLTLCC

I V IS SP F G T + CC

IGVGISLAWCSPGGTFCGSCTFGTSGCC

with 1 more sequence matches

13.0%

NZ_CP050440.1:

Lanthipeptides: allorf_0199281_0199457_lanthipeptide

SDFYIQVNISSSPKANFMG

S+F++Q+ + S P G

SEFWVQIKVDSLPTPKLTG

MIBiG 4.0 matches for allorf_096778_096948

13.0%

BGC0000563.4 (AEA03263.1):

Lanthipeptide: venezuelin

MGYLTILLTLC

+G LT+L T+C

VGLLTLLNTVC

allorf_097220_097294

Leader:

MYITTRHHEGGA

Core:

CIYLLHLKCTVA

Core with dehydrations:

CysIYLLHLKCysDhbVA

antiSMASH-DB 4.0 matches for allorf_097220_097294

100.0%

NC_014643.1and 1 other:

NZ_KV804818.1 Lanthipeptides: allorf_097220_097294_lanthipeptide

Lanthipeptides: allorf_1154776_1154850_lanthipeptide

CIYLLHLKCTVA

Lanthipeptide(s) for HMPREF2804_RS09470

HMPREF2804_RS09455

Leader:

MAQNDHQDKHPKRKEIPSSLWVFALATFVLALPRIGDGRILPLDLTTSFILGA

Core:

VLIVCGFWMMYREHKKSSAQKK

Core with dehydrations:

VLIVCysGFWMMYREHKKDhaDhaAQKK

antiSMASH-DB 4.0 matches for HMPREF2804_RS09455

100.0%

NZ_JVXR01000038.1and 6 others:

Lanthipeptides: ADK06_RS05035_lanthipeptide

VLIVCGFWMMYREHKKSSAQKK

26.9%

NZ_KZ268499.1:

Lanthipeptides: allorf_4452434_4452649_lanthipeptide

VCGFWMMYREHKKSSA

+CG R H KSS+

LCGLCTFIRAHPKSSS

20.0%

NZ_CP066762.1:

Lanthipeptides: JG536_RS12630_lanthipeptide

IVCG--FWMMYREHKKSS

IV G MM+R+HK S

IVIGALLAMMHRKHKYSP

with 1 more sequence matches

18.2%

NZ_QPIX01000013.1:

Lanthipeptides: allorf_114776_114868_lanthipeptide

LIVCGFWMMYREH

L+ C W+ Y+++

LLACSHWLRYKDN

HMPREF2804_RS09475

Leader:

MAKDITLLEEISDLDLDQVNGS

Core:

GHGGGGYSGGGYNGGGNYCGNGCGNYNFGFGFWGGSSS

Core with dehydrations:

GHGGGGYDhaGGGYNGGGNYCysGNGCysGNYNFGFGFWGGDhaDhaDha

antiSMASH-DB 4.0 matches for HMPREF2804_RS09475

100.0%

NZ_KV804818.1and 1 other:

NZ_KV804818.1 Lanthipeptides: HMPREF2804_RS09475_lanthipeptide

Lanthipeptides: HMPREF2804_RS09475_lanthipeptide

GHGGGGYSGGGYNGGGNYCGNGCGNYNFGFGFWGGSSS

86.0%

NZ_KV802313.1:

Lanthipeptides: HMPREF2756_RS06530_lanthipeptide

GHGGGGYSGGGYNGGGN-----YCGNGCGNYNFGFGFWGGSSS

GHGGGGYSGGGY+GGGN YCGNGCGNYNFGFGFWGGSSS

GHGGGGYSGGGYSGGGNGGGGNYCGNGCGNYNFGFGFWGGSSS

25.0%

NC_014643.1and 13 others:

NC_014643.1 Lanthipeptides: HMPREF0733_RS05060_lanthipeptideNZ_CP054018.1 Lanthipeptides: FOC60_RS00340_lanthipeptideNZ_CP079201.1 Lanthipeptides: LPB409_RS01335_lanthipeptideNZ_JVLW01000024.1 Lanthipeptides: ADD47_RS04725_lanthipeptideNZ_JVXR01000038.1 Lanthipeptides: ADK06_RS05015_lanthipeptideNZ_KV793075.1 Lanthipeptides: HMPREF3164_RS06945_lanthipeptideNZ_KV795763.1 Lanthipeptides: HMPREF2554_RS09025_lanthipeptideNZ_KV795763.1 Lanthipeptides: HMPREF2554_RS09025_lanthipeptideNZ_KV797630.1 Lanthipeptides: HMPREF2609_RS06005_lanthipeptideNZ_KV797887.1 Lanthipeptides: HMPREF2625_RS00515_lanthipeptideNZ_KV815277.1 Lanthipeptides: HMPREF2958_RS01940_lanthipeptideNZ_KV817389.1 Lanthipeptides: HMPREF2981_RS04625_lanthipeptideNZ_KV820076.1 Lanthipeptides: HMPREF3016_RS03055_lanthipeptide

Lanthipeptides: HMPREF0733_RS05060_lanthipeptide

FGFGFWGGSSS

with 1 more sequence matches

10.0%

NZ_PVTF01000002.1:

Lanthipeptides: allorf_797510_797749_lanthipeptide

CGNYNFGFGFWGGS

CG + G FW S

CGRLDLGPLFWASS

MIBiG 4.0 matches for HMPREF2804_RS09475

10.5%

BGC0002322.3 (CEJ66604.1):

Lasso peptide: citrocin

YCGNGCGNY

+ G G G Y

FIGGGVGRY

HMPREF2804_RS11470

Leader:

MPQDITLLEEISEQDLSQVNGG

Core:

TAFPGWYSKVIGNRGRVCTVTVECMSVCQ

Core with dehydrations:

DhbAFPGWYDhaKVIGNRGRVCysDhbVDhbVECysMDhaVCysQ

antiSMASH-DB 4.0 matches for HMPREF2804_RS11470

100.0%

NZ_KV795763.1and 2 others:

NZ_KV804818.1 Lanthipeptides: allorf_114850_115005_lanthipeptideNZ_KV804818.1 Lanthipeptides: allorf_114850_115005_lanthipeptide

Lanthipeptides: allorf_248182_248337_lanthipeptide

TAFPGWYSKVIGNRGRVCTVTVECMSVCQ

50.0%

NZ_CP043405.1and 1 other:

NZ_CP043405.1 Lanthipeptides: FY406_RS04355_lanthipeptide

Lanthipeptides: FY406_RS04355_lanthipeptide

TAFPGWYSKVIGNRGRVCTVTVECMSVCQ

T +S V+GN+G +CTVTVECM CQ

TVVNSTFSIVLGNKGYICTVTVECMRNCQ

48.3%

NZ_CP006058.1and 23 others:

NZ_CP006058.1 Lanthipeptides: BAMY6639_RS13800_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptide

Lanthipeptides: BAMY6639_RS13800_lanthipeptide

GWY--SKVIGNRGRVCTVTVECMSVCQ

WY S +GN+G CT+TVEC S C

AWYDISCKLGNKGAWCTLTVECQSSCN

with 108 more sequence matches

Only the first 10 are displayed here.

48.3%

NZ_CP025249.1and 1 other:

NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide

Lanthipeptides: CWT12_RS00385_lanthipeptide

FPGWYSKVIGNRGRVCTVTVECMSVCQ

FP W S+ +GN G VCT+T EC +C

FP-WLSRKLGNTGYVCTLTKECQRMCN

48.3%

NZ_FOBE01000018.1:

Lanthipeptides: BMW61_RS13085_lanthipeptide

GWYSKV---IGNRGRVCTVTVECMSVCQ

GWYS++ +GNRG CT+T EC + C

GWYSEMSAALGNRGSYCTLTKECQACCN

48.3%

NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS01725_lanthipeptide

Lanthipeptides: EL241_RS01725_lanthipeptide

GW--YSKVIGNRGRVCTVTVECMSVCQ

GW SK +GN+G VCT+T EC +C+

GWKDLSKSLGNKGYVCTLTKECQKLCR

45.5%

NC_018089.1and 11 others:

NC_018089.1 Lanthipeptides: SMUGS5_RS08725_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09065_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09065_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00325_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00325_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03985_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03985_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08120_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08120_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05515_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05515_lanthipeptide

Lanthipeptides: SMUGS5_RS08725_lanthipeptide

TAFPGWYSKVIGNRGRVCTVTVECMSVCQ

T +S V+GN+G +CTVTVECM C

TVVNSTFSIVLGNKGYICTVTVECMRNCS

44.8%

NZ_CP030280.1and 1 other:

NZ_CP030280.1 Lanthipeptides: DQQ01_RS07655_lanthipeptide

Lanthipeptides: DQQ01_RS07655_lanthipeptide

SKVIGNRGRVCTVTVECMSVCQ

SK GN G +C+VTVECM +C

SKDWGNDGYLCSVTVECMIICN

44.8%

NZ_CP030280.1and 3 others:

NZ_CP030280.1 Lanthipeptides: DQQ01_RS07645_lanthipeptideNZ_CP030280.1 Lanthipeptides: DQQ01_RS07650_lanthipeptideNZ_CP030280.1 Lanthipeptides: DQQ01_RS07645_lanthipeptide

Lanthipeptides: DQQ01_RS07650_lanthipeptide

SKVIGNRGRVCTVTVECMSVCQ

SK GN G +C+VTVECM +C

SKDWGNDGYLCSVTVECMVICN

44.8%

NZ_CP063276.1and 1 other:

NZ_CP063276.1 Lanthipeptides: IM743_RS02795_lanthipeptide

Lanthipeptides: IM743_RS02795_lanthipeptide

GWY--SKVIGNRGRVCTVTVECMSVCQ

WY S +GN+G CT+TVEC + C

AWYDVSCRLGNKGAWCTLTVECQNNCN

44.8%

NZ_KE384107.1:

Lanthipeptides: G586_RS23925_lanthipeptide

GWYSKV---IGNRGRVCTVTVECMSVCQ

GWY+ + +GNRG CT+T EC + C

GWYADLSASLGNRGSYCTITKECQACCN

44.8%

NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS01720_lanthipeptide

Lanthipeptides: EL241_RS01720_lanthipeptide

SKVIGNRGRVCTVTVECMSVCQ

SK +GN+GR+CT+T EC S+C

SKNLGNKGRICTLTKECQSMCN

43.8%

NC_002570.2and 3 others:

NC_002570.2 Lanthipeptides: AYT26_RS02480_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptide

Lanthipeptides: AYT26_RS02480_lanthipeptide

GWY--SKVIGNRGRVCTVTVECMSVCQ

WY S +GN+G CT+TVECM C

AWYNISCRLGNKGAYCTLTVECMPSCN

MIBiG 4.0 matches for HMPREF2804_RS11470

48.3%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

GWY--SKVIGNRGRVCTVTVECMSVCQ

WY S +GN+G CT+TVECM C

AWYNISCRLGNKGAYCTLTVECMPSCN

33.3%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

SKVIGNRGRVCTVTVECMSVCQ

S +GN G CT+T EC C

SNALGNNGGWCTLTKECQPNCN

12.8%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

CTVTVECMSVCQ

CT++ EC C

CTLSKECQPNCN

allorf_096778_096948

Leader:

MTILEHIRQA

Core:

TCDTCSYVEYIIVSDFYIQVNISSSPKANFMGYLTILLTLCCIPSE

Core with dehydrations:

DhbCysDDhbCysDhaYVEYIIVDhaDFYIQVNIDhaDhaDhaPKANFMGYLDhbILLDhbLCysCysIPDhaE

antiSMASH-DB 4.0 matches for allorf_096778_096948

100.0%

NC_014643.1and 1 other:

NZ_KV804818.1 Lanthipeptides: allorf_096778_096948_lanthipeptide

Lanthipeptides: allorf_1155122_1155292_lanthipeptide

TCDTCSYVEYIIVSDFYIQVNISSSPKANFMGYLTILLTLCCIPSE

26.1%

NZ_JAOQJV010000004.1:

Lanthipeptides: OCV65_RS05205_lanthipeptide

EYIIVSDFYIQVNISSSPKANFMGYLTILLTLCC

EY ++ D QV + ++ N G+LTI +CC

EYNMLMDEAEQVVVYATQSGNCSGFLTI---ICC

23.9%

NZ_CP013979.1:

Lanthipeptides: allorf_0343557_0343787_lanthipeptide

IQVNIS---SSPKANFMGYLTILLTLCC

I V IS SP F G T + CC

IGVGISLAWCSPGGTFCGSCTFGTSGCC

with 1 more sequence matches

13.0%

NZ_CP050440.1:

Lanthipeptides: allorf_0199281_0199457_lanthipeptide

SDFYIQVNISSSPKANFMG

S+F++Q+ + S P G

SEFWVQIKVDSLPTPKLTG

MIBiG 4.0 matches for allorf_096778_096948

13.0%

BGC0000563.4 (AEA03263.1):

Lanthipeptide: venezuelin

MGYLTILLTLC

+G LT+L T+C

VGLLTLLNTVC

allorf_097220_097294

Leader:

MYITTRHHEGGA

Core:

CIYLLHLKCTVA

Core with dehydrations:

CysIYLLHLKCysDhbVA

antiSMASH-DB 4.0 matches for allorf_097220_097294

100.0%

NC_014643.1and 1 other:

NZ_KV804818.1 Lanthipeptides: allorf_097220_097294_lanthipeptide

Lanthipeptides: allorf_1154776_1154850_lanthipeptide

CIYLLHLKCTVA

allorf_109292_109366

Leader:

MLLRNLNFM

Core:

GEILCGLRGTCRAGF

Core with dehydrations:

GEILCysGLRGDhbCysRAGF

antiSMASH-DB 4.0 matches for allorf_109292_109366

100.0%

NZ_CP054018.1and 3 others:

NZ_KV804818.1 Lanthipeptides: allorf_109292_109366_lanthipeptideNZ_KV804818.1 Lanthipeptides: allorf_109292_109366_lanthipeptideNZ_KV820076.1 Lanthipeptides: allorf_134599_134673_lanthipeptide

Lanthipeptides: allorf_0084035_0084109_lanthipeptide

GEILCGLRGTCRAGF

25.0%

NZ_KB900614.1:

Lanthipeptides: allorf_2952909_2953064_lanthipeptide

LCGLRGTCRAGF

+C +G CR GF

VCAFKGHCRIGF

allorf_109330_109521

Leader:

MRFEGNLPRWFLKKHQKNLDAVAQA

Core:

ARLCDSIHVFRLLYGSGYLLVQAATHIHNDFPKPQGRL

Core with dehydrations:

ARLCysDDhaIHVFRLLYGDhaGYLLVQAADhbHIHNDFPKPQGRL

antiSMASH-DB 4.0 matches for allorf_109330_109521

100.0%

NZ_KV804818.1and 1 other:

NZ_KV804818.1 Lanthipeptides: allorf_109330_109521_lanthipeptide

Lanthipeptides: allorf_109330_109521_lanthipeptide

ARLCDSIHVFRLLYGSGYLLVQAATHIHNDFPKPQGRL

18.4%

NZ_NIST01000001.1:

Lassopeptides: CD001_RS25955_lassopeptide

THIHNDFPKPQGR

+H+ NDFP+ GR

SHLDNDFPEGTGR

15.8%

NZ_JVXR01000038.1:

Lanthipeptides: allorf_10259_10360_lanthipeptide

ARLCDSIH

ARLCDS+

ARLCDSVQ

allorf_115697_115819

Leader:

MRVLIYLSVIEAKTSLAR

Core:

WRIPGDISPEICGTPRRVLTST

Core with dehydrations:

WRIPGDIDhaPEICysGDhbPRRVLDhbDhaDhb

antiSMASH-DB 4.0 matches for allorf_115697_115819

100.0%

NZ_KV804818.1and 1 other:

NZ_KV804818.1 Lanthipeptides: allorf_115697_115819_lanthipeptide

Lanthipeptides: allorf_115697_115819_lanthipeptide

WRIPGDISPEICGTPRRVLTST

30.0%

NC_018499.1and 1 other:

NC_018499.1 Lanthipeptides: BCK_RS27825_lanthipeptide

Lanthipeptides: BCK_RS27825_lanthipeptide

GDISPEICGTPRRVLT

GD++PEI TP V T

GDVNPEIAPTPHTVTT

29.2%

NZ_FUXI01000002.1:

Lanthipeptides: B5D30_RS01240_lanthipeptide

GDISPEICGTPRRVLTS

GD++P+ G+ LTS

GDVNPQTVGSLWEFLTS

with 9 more sequence matches

26.7%

NZ_MLKL01000042.1:

Lanthipeptides: BKK45_RS27420_lanthipeptide

GDISPEICGTPRRVLT

GD++PE TP V T

GDVNPETAPTPHTVTT

25.0%

NZ_JACIJS010000004.1:

Lanthipeptides: allorf_030388_030501_lanthipeptide

GDISPEICGT

GD+SP +CG

GDLSPCVCGA

25.0%

NZ_QSIO01000003.1:

Lanthipeptides: DW820_RS07295_lanthipeptide

GDISPEICGTPRRVL

GDISPE TP VL

GDISPET--TPACVL

20.0%

NZ_CP075910.1and 3 others:

NZ_CP075971.1 Lanthipeptides: KLF29_RS14850_lanthipeptideNZ_CP075982.1 Lanthipeptides: KLF51_RS14900_lanthipeptideNZ_CP075994.1 Lanthipeptides: KLF26_RS16110_lanthipeptide

Lanthipeptides: KLF45_RS14835_lanthipeptide

WRIPGDISPEICGTPRRVLT

+ PG ++ E+CG+ LT

YCTPGCLTGELCGSSECGLT

17.6%

NZ_CABIWO010000014.1:

Lanthipeptides: FY209_RS17155_lanthipeptide

WRIPGDISPEICGTPRRVLT

+ PG ++ ++CG+ LT

YCTPGCVTGQLCGSSECGLT

17.1%

NC_018499.1and 1 other:

NC_018499.1 Lanthipeptides: BCK_RS27830_lanthipeptide

Lanthipeptides: BCK_RS27830_lanthipeptide

GDISPEICGTP

GD++PEI P

GDVNPEIMSDP

15.0%

NZ_JAFHCX010000012.1and 1 other:

NZ_LR738722.1 Lanthipeptides: STREPSUIS_RS04075_lanthipeptide

Lanthipeptides: JXW96_RS06965_lanthipeptide

GDISPE

14.6%

NZ_CP051486.1:

Lanthipeptides: allorf_6974648_6974821_lanthipeptide

RIPGDISPEICGT

R+PG + P CG

RVPGRVLPGRCGA

10.7%

NC_016582.1:

Lanthipeptides: allorf_10870098_10870307_lanthipeptide

CGTPRRVL

CGT RR+L

CGTSRRLL

allorf_115961_116155

Leader:

MVTSATIQVKVCTVGYGFRIHLYRQVKSLYS

Core:

PCLGQGRVSSPSNLHIILRPLSMFGVVIRKYFD

Core with dehydrations:

PCysLGQGRVDhaDhaPDhaNLHIILRPLDhaMFGVVIRKYFD

antiSMASH-DB 4.0 matches for allorf_115961_116155

100.0%

NZ_KV795763.1and 2 others:

NZ_KV804818.1 Lanthipeptides: allorf_115961_116155_lanthipeptideNZ_KV804818.1 Lanthipeptides: allorf_115961_116155_lanthipeptide

Lanthipeptides: allorf_249293_249487_lanthipeptide

PCLGQGRVSSPSNLHIILRPLSMFGVVIRKYFD

24.2%

NZ_BMUN01000001.1and 9 others:

NZ_CP012382.1 Lanthipeptides: SAM23877_RS36835_lanthipeptideNZ_CP012949.1 Lanthipeptides: SAM40697_RS33360_lanthipeptideNZ_CP027299.1 Lanthipeptides: C1N79_RS34825_lanthipeptideNZ_CP039123.1 Lanthipeptides: E5N77_RS35110_lanthipeptideNZ_CP104697.1 Lanthipeptides: N6Q81_RS33410_lanthipeptideNZ_CP104697.1 Lanthipeptides: N6Q81_RS33410_lanthipeptideNZ_JACWAA010000001.1 Lanthipeptides: ICA23_RS00945_lanthipeptideNZ_KZ195574.1 Lanthipeptides: B9W62_RS39030_lanthipeptideNZ_MQUH01000030.1 Lanthipeptides: BSZ07_RS37165_lanthipeptide

Lanthipeptides: IE238_RS00870_lanthipeptide

LGQGRVSSPSNLHIILR

GQG +SPS+ I R

FGQGTFTSPSSYAIGTR

24.2%

NZ_CP043959.1and 8 others:

NZ_CP054939.1 Lanthipeptides: HUT14_RS33610_lanthipeptideNZ_CP104864.1 Lanthipeptides: N7E53_RS01070_lanthipeptideNZ_FKJH01000076.1 Lanthipeptides: STEPF7_RS31605_lanthipeptideNZ_GG657758.1 Lanthipeptides: SSRG_RS36710_lanthipeptideNZ_JMLN01000003.1 Lanthipeptides: BR33_RS35695_lanthipeptideNZ_KL503830.1 Lanthipeptides: DJ64_RS34550_lanthipeptideNZ_VIUV01000001.1 Lanthipeptides: FB570_RS00565_lanthipeptideNZ_WUUF01000042.1 Lanthipeptides: GSE51_RS09870_lanthipeptide

Lanthipeptides: F3L20_RS18420_lanthipeptide

LGQGRVSSPSNLHIILR

GQG +SPS+ I R

FGQGTYTSPSSYAIGTR

with 5 more sequence matches

24.2%

NZ_CP058273.1:

Lanthipeptides: AY578_RS00390_lanthipeptide

GQGRVSSPSNLHIILR

GQG +SPS+ I R

GQGTYTSPSSYAIGTR

21.2%

NZ_BEWD01000004.1and 5 others:

NZ_BMVQ01000001.1 Lanthipeptides: IE283_RS00890_lanthipeptideNZ_BMWI01000001.1 Lanthipeptides: IE253_RS05465_lanthipeptideNZ_CP042324.1 Lanthipeptides: FQ762_RS01285_lanthipeptideNZ_GG657756.1 Lanthipeptides: SSPG_RS36720_lanthipeptideNZ_LT629768.1 Lanthipeptides: BLU60_RS01655_lanthipeptide

Lanthipeptides: Sru02f_RS16280_lanthipeptide

LGQGRVSSPSNLHIILR

G+G +SPS+ I R

FGEGTFTSPSSYAIGTR

21.2%

NZ_CP023699.1:

Lassopeptides: CP970_RS43860_lassopeptide

RPLSMFGVVIR

RPL FG+ IR

RPLDSFGLNIR

20.0%

NZ_CP067396.1:

Lanthipeptides: JHW41_RS12400_lanthipeptide

SSPSNLHIILRPLSM

+ PS H +LR LSM

TGPSGAHGLLRCLSM

13.3%

NZ_CP078093.1:

Lanthipeptides: KVH43_RS13030_lanthipeptide

HIILRPLSMFGVVIRKY

+ + PL+ + V+ RKY

NWTMNPLTCYTVLSRKY

allorf_117600_117668

Leader:

MSPYFQDLSLIHAA

Core:

LQTCLTKS

Core with dehydrations:

LQDhbCysLDhbKDha

antiSMASH-DB 4.0 matches for allorf_117600_117668

100.0%

NZ_KV795763.1and 2 others:

NZ_KV804818.1 Lanthipeptides: allorf_117600_117668_lanthipeptideNZ_KV804818.1 Lanthipeptides: allorf_117600_117668_lanthipeptide

Lanthipeptides: allorf_250932_251000_lanthipeptide

LQTCLTKS

allorf_117642_117731

Leader:

MFTLSGLNAWSGS

Core:

FLLIYSFHLAFCKTCL

Core with dehydrations:

FLLIYDhaFHLAFCysKDhbCysL

antiSMASH-DB 4.0 matches for allorf_117642_117731

100.0%

NZ_KV795763.1and 2 others:

NZ_KV804818.1 Lanthipeptides: allorf_117642_117731_lanthipeptideNZ_KV804818.1 Lanthipeptides: allorf_117642_117731_lanthipeptide

Lanthipeptides: allorf_250974_251063_lanthipeptide

FLLIYSFHLAFCKTCL

23.1%

NC_014483.2and 18 others:

NC_014622.2 Lanthipeptides: PPSC2_RS36205_lanthipeptideNC_017542.1 Lanthipeptides: PPM_RS07465_lanthipeptideNZ_CP006872.1 Lanthipeptides: PPSQR21_RS07740_lanthipeptideNZ_CP023711.1 Lanthipeptides: CPY53_RS22235_lanthipeptideNZ_CP025957.1 Lanthipeptides: C1A50_RS07530_lanthipeptideNZ_CP029370.1 Lanthipeptides: DI243_RS07495_lanthipeptideNZ_CP040829.1 Lanthipeptides: FGY93_RS00500_lanthipeptideNZ_CP049598.1 Lanthipeptides: G7L40_RS00115_lanthipeptideNZ_CP073682.1 Lanthipeptides: KAI36_RS07745_lanthipeptideNZ_CP084033.1 Lanthipeptides: LAZ93_RS07550_lanthipeptideNZ_CP085682.1 Lanthipeptides: LJR53_RS07370_lanthipeptideNZ_CP086373.1 Lanthipeptides: LMH85_RS07780_lanthipeptideNZ_CP092779.1 Lanthipeptides: MJ749_RS07440_lanthipeptideNZ_CP097766.1 Lanthipeptides: MF620_RS07485_lanthipeptideNZ_CP102865.1 Lanthipeptides: NWS42_RS21195_lanthipeptideNZ_JAKVDC010000001.1 Lanthipeptides: MKN04_RS02755_lanthipeptideNZ_JWJJ01000002.1 Lanthipeptides: U707_RS10390_lanthipeptideNZ_POVT01000009.1 Lanthipeptides: C1T20_RS05900_lanthipeptide

Lanthipeptides: PPE_RS07020_lanthipeptide

FHLAFCKTC

L+FCKTC

VSLSFCKTC

23.1%

NC_023037.2and 11 others:

NZ_CP017967.2 Lanthipeptides: PPYC1_RS07755_lanthipeptideNZ_CP017968.3 Lanthipeptides: PPYC2_RS08330_lanthipeptideNZ_CP061172.1 Lanthipeptides: IAQ67_RS07480_lanthipeptideNZ_CP073683.1 Lanthipeptides: KAI37_RS07495_lanthipeptideNZ_CP109848.1 Lanthipeptides: OF859_RS22650_lanthipeptideNZ_CP113973.1 Lanthipeptides: OYT09_RS07785_lanthipeptideNZ_FOYG01000001.1 Lanthipeptides: BM358_RS03525_lanthipeptideNZ_JAAMNR010000001.1 Lanthipeptides: G9G54_RS03500_lanthipeptideNZ_PNXQ01000013.1 Lanthipeptides: C1I60_RS14430_lanthipeptideNZ_POVS01000009.1 Lanthipeptides: C1T21_RS10630_lanthipeptideNZ_PTJM01000020.1 Lanthipeptides: C5G87_RS02825_lanthipeptide

Lanthipeptides: X809_RS07820_lanthipeptide

FHLAFCKTC

L FCKTC

VSLTFCKTC

with 3 more sequence matches

19.2%

NZ_JAIFIS010000001.1:

Lanthipeptides: K1X09_RS26315_lanthipeptide

FHLAFCKTC

L+FC+TC

ISLSFCRTC

18.6%

NZ_QKUF01000009.1:

Lanthipeptides: allorf_200737_200904_lanthipeptide

LLIYSFHLAFCKTC

LLI SF FC+ C

LLIRSFSYNFCRQC

11.8%

NZ_BOSN01000007.1and 3 others:

NZ_BOSN01000007.1 Lanthipeptides: allorf_257698_257880_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: allorf_13614_13796_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: allorf_13614_13796_lanthipeptide

Lanthipeptides: allorf_257698_257880_lanthipeptide

IYSFHLAFCKTC

+YSF++ C TC

LYSFYIHKCSTC

Lanthipeptide(s) for HMPREF2804_RS09490

HMPREF2804_RS09455

Leader:

MAQNDHQDKHPKRKEIPSSLWVFALATFVLALPRIGDGRILPLDLTTSFILGA

Core:

VLIVCGFWMMYREHKKSSAQKK

Core with dehydrations:

VLIVCysGFWMMYREHKKDhaDhaAQKK

antiSMASH-DB 4.0 matches for HMPREF2804_RS09455

100.0%

NZ_JVXR01000038.1and 6 others:

Lanthipeptides: ADK06_RS05035_lanthipeptide

VLIVCGFWMMYREHKKSSAQKK

26.9%

NZ_KZ268499.1:

Lanthipeptides: allorf_4452434_4452649_lanthipeptide

VCGFWMMYREHKKSSA

+CG R H KSS+

LCGLCTFIRAHPKSSS

20.0%

NZ_CP066762.1:

Lanthipeptides: JG536_RS12630_lanthipeptide

IVCG--FWMMYREHKKSS

IV G MM+R+HK S

IVIGALLAMMHRKHKYSP

with 1 more sequence matches

18.2%

NZ_QPIX01000013.1:

Lanthipeptides: allorf_114776_114868_lanthipeptide

LIVCGFWMMYREH

L+ C W+ Y+++

LLACSHWLRYKDN

HMPREF2804_RS09475

Leader:

MAKDITLLEEISDLDLDQVNGS

Core:

GHGGGGYSGGGYNGGGNYCGNGCGNYNFGFGFWGGSSS

Core with dehydrations:

GHGGGGYDhaGGGYNGGGNYCysGNGCysGNYNFGFGFWGGDhaDhaDha

antiSMASH-DB 4.0 matches for HMPREF2804_RS09475

100.0%

NZ_KV804818.1and 1 other:

NZ_KV804818.1 Lanthipeptides: HMPREF2804_RS09475_lanthipeptide

Lanthipeptides: HMPREF2804_RS09475_lanthipeptide

GHGGGGYSGGGYNGGGNYCGNGCGNYNFGFGFWGGSSS

86.0%

NZ_KV802313.1:

Lanthipeptides: HMPREF2756_RS06530_lanthipeptide

GHGGGGYSGGGYNGGGN-----YCGNGCGNYNFGFGFWGGSSS

GHGGGGYSGGGY+GGGN YCGNGCGNYNFGFGFWGGSSS

GHGGGGYSGGGYSGGGNGGGGNYCGNGCGNYNFGFGFWGGSSS

25.0%

NC_014643.1and 13 others:

Lanthipeptides: HMPREF0733_RS05060_lanthipeptide

FGFGFWGGSSS

with 1 more sequence matches

10.0%

NZ_PVTF01000002.1:

Lanthipeptides: allorf_797510_797749_lanthipeptide

CGNYNFGFGFWGGS

CG + G FW S

CGRLDLGPLFWASS

MIBiG 4.0 matches for HMPREF2804_RS09475

10.5%

BGC0002322.3 (CEJ66604.1):

Lasso peptide: citrocin

YCGNGCGNY

+ G G G Y

FIGGGVGRY

HMPREF2804_RS11470

Leader:

MPQDITLLEEISEQDLSQVNGG

Core:

TAFPGWYSKVIGNRGRVCTVTVECMSVCQ

Core with dehydrations:

DhbAFPGWYDhaKVIGNRGRVCysDhbVDhbVECysMDhaVCysQ

antiSMASH-DB 4.0 matches for HMPREF2804_RS11470

100.0%

NZ_KV795763.1and 2 others:

NZ_KV804818.1 Lanthipeptides: allorf_114850_115005_lanthipeptideNZ_KV804818.1 Lanthipeptides: allorf_114850_115005_lanthipeptide

Lanthipeptides: allorf_248182_248337_lanthipeptide

TAFPGWYSKVIGNRGRVCTVTVECMSVCQ

50.0%

NZ_CP043405.1and 1 other:

NZ_CP043405.1 Lanthipeptides: FY406_RS04355_lanthipeptide

Lanthipeptides: FY406_RS04355_lanthipeptide

TAFPGWYSKVIGNRGRVCTVTVECMSVCQ

T +S V+GN+G +CTVTVECM CQ

TVVNSTFSIVLGNKGYICTVTVECMRNCQ

48.3%

NZ_CP006058.1and 23 others:

Lanthipeptides: BAMY6639_RS13800_lanthipeptide

GWY--SKVIGNRGRVCTVTVECMSVCQ

WY S +GN+G CT+TVEC S C

AWYDISCKLGNKGAWCTLTVECQSSCN

with 108 more sequence matches

Only the first 10 are displayed here.

48.3%

NZ_CP025249.1and 1 other:

NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide

Lanthipeptides: CWT12_RS00385_lanthipeptide

FPGWYSKVIGNRGRVCTVTVECMSVCQ

FP W S+ +GN G VCT+T EC +C

FP-WLSRKLGNTGYVCTLTKECQRMCN

48.3%

NZ_FOBE01000018.1:

Lanthipeptides: BMW61_RS13085_lanthipeptide

GWYSKV---IGNRGRVCTVTVECMSVCQ

GWYS++ +GNRG CT+T EC + C

GWYSEMSAALGNRGSYCTLTKECQACCN

48.3%

NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS01725_lanthipeptide

Lanthipeptides: EL241_RS01725_lanthipeptide

GW--YSKVIGNRGRVCTVTVECMSVCQ

GW SK +GN+G VCT+T EC +C+

GWKDLSKSLGNKGYVCTLTKECQKLCR

45.5%

NC_018089.1and 11 others:

Lanthipeptides: SMUGS5_RS08725_lanthipeptide

TAFPGWYSKVIGNRGRVCTVTVECMSVCQ

T +S V+GN+G +CTVTVECM C

TVVNSTFSIVLGNKGYICTVTVECMRNCS

44.8%

NZ_CP030280.1and 1 other:

NZ_CP030280.1 Lanthipeptides: DQQ01_RS07655_lanthipeptide

Lanthipeptides: DQQ01_RS07655_lanthipeptide

SKVIGNRGRVCTVTVECMSVCQ

SK GN G +C+VTVECM +C

SKDWGNDGYLCSVTVECMIICN

44.8%

NZ_CP030280.1and 3 others:

NZ_CP030280.1 Lanthipeptides: DQQ01_RS07645_lanthipeptideNZ_CP030280.1 Lanthipeptides: DQQ01_RS07650_lanthipeptideNZ_CP030280.1 Lanthipeptides: DQQ01_RS07645_lanthipeptide

Lanthipeptides: DQQ01_RS07650_lanthipeptide

SKVIGNRGRVCTVTVECMSVCQ

SK GN G +C+VTVECM +C

SKDWGNDGYLCSVTVECMVICN

44.8%

NZ_CP063276.1and 1 other:

NZ_CP063276.1 Lanthipeptides: IM743_RS02795_lanthipeptide

Lanthipeptides: IM743_RS02795_lanthipeptide

GWY--SKVIGNRGRVCTVTVECMSVCQ

WY S +GN+G CT+TVEC + C

AWYDVSCRLGNKGAWCTLTVECQNNCN

44.8%

NZ_KE384107.1:

Lanthipeptides: G586_RS23925_lanthipeptide

GWYSKV---IGNRGRVCTVTVECMSVCQ

GWY+ + +GNRG CT+T EC + C

GWYADLSASLGNRGSYCTITKECQACCN

44.8%

NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS01720_lanthipeptide

Lanthipeptides: EL241_RS01720_lanthipeptide

SKVIGNRGRVCTVTVECMSVCQ

SK +GN+GR+CT+T EC S+C

SKNLGNKGRICTLTKECQSMCN

43.8%

NC_002570.2and 3 others:

NC_002570.2 Lanthipeptides: AYT26_RS02480_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptide

Lanthipeptides: AYT26_RS02480_lanthipeptide

GWY--SKVIGNRGRVCTVTVECMSVCQ

WY S +GN+G CT+TVECM C

AWYNISCRLGNKGAYCTLTVECMPSCN

MIBiG 4.0 matches for HMPREF2804_RS11470

48.3%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

GWY--SKVIGNRGRVCTVTVECMSVCQ

WY S +GN+G CT+TVECM C

AWYNISCRLGNKGAYCTLTVECMPSCN

33.3%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

SKVIGNRGRVCTVTVECMSVCQ

S +GN G CT+T EC C

SNALGNNGGWCTLTKECQPNCN

12.8%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

CTVTVECMSVCQ

CT++ EC C

CTLSKECQPNCN

HMPREF2804_RS11475

Leader:

MMMNVSDLANSIEIDTTPGA

Core:

ADYAMNSAQPSMTTPAGVYAVAEMAVAGSTICLVC

Core with dehydrations:

ADYAMNDhaAQPDhaMDhbDhbPAGVYAVAEMAVAGDhaDhbICysLVCys

antiSMASH-DB 4.0 matches for HMPREF2804_RS11475

100.0%

NZ_KV795763.1and 1 other:

NZ_KV804818.1 Lanthipeptides: allorf_121741_121908_lanthipeptide

Lanthipeptides: allorf_255073_255240_lanthipeptide

ADYAMNSAQPSMTTPAGVYAVAEMAVAGSTICLVC

17.1%

NZ_CP048812.1:

Lassopeptides: G3568_RS19655_lassopeptide

QPSMTTPAGVYAVAEM

QP+ TP G+ A

QPNADTPGGLNNTANK

MIBiG 4.0 matches for HMPREF2804_RS11475

28.6%

BGC0000582.4 (ADR72962.1):

Linaridin: cypemycin

VAEMAVAGSTICLVC

VA+ + GSTICLVC

VAQFVIQGSTICLVC

allorf_109292_109366

Leader:

MLLRNLNFM

Core:

GEILCGLRGTCRAGF

Core with dehydrations:

GEILCysGLRGDhbCysRAGF

antiSMASH-DB 4.0 matches for allorf_109292_109366

100.0%

NZ_CP054018.1and 3 others:

NZ_KV804818.1 Lanthipeptides: allorf_109292_109366_lanthipeptideNZ_KV804818.1 Lanthipeptides: allorf_109292_109366_lanthipeptideNZ_KV820076.1 Lanthipeptides: allorf_134599_134673_lanthipeptide

Lanthipeptides: allorf_0084035_0084109_lanthipeptide

GEILCGLRGTCRAGF

25.0%

NZ_KB900614.1:

Lanthipeptides: allorf_2952909_2953064_lanthipeptide

LCGLRGTCRAGF

+C +G CR GF

VCAFKGHCRIGF

allorf_109330_109521

Leader:

MRFEGNLPRWFLKKHQKNLDAVAQA

Core:

ARLCDSIHVFRLLYGSGYLLVQAATHIHNDFPKPQGRL

Core with dehydrations:

ARLCysDDhaIHVFRLLYGDhaGYLLVQAADhbHIHNDFPKPQGRL

antiSMASH-DB 4.0 matches for allorf_109330_109521

100.0%

NZ_KV804818.1and 1 other:

NZ_KV804818.1 Lanthipeptides: allorf_109330_109521_lanthipeptide

Lanthipeptides: allorf_109330_109521_lanthipeptide

ARLCDSIHVFRLLYGSGYLLVQAATHIHNDFPKPQGRL

18.4%

NZ_NIST01000001.1:

Lassopeptides: CD001_RS25955_lassopeptide

THIHNDFPKPQGR

+H+ NDFP+ GR

SHLDNDFPEGTGR

15.8%

NZ_JVXR01000038.1:

Lanthipeptides: allorf_10259_10360_lanthipeptide

ARLCDSIH

ARLCDS+

ARLCDSVQ

allorf_115697_115819

Leader:

MRVLIYLSVIEAKTSLAR

Core:

WRIPGDISPEICGTPRRVLTST

Core with dehydrations:

WRIPGDIDhaPEICysGDhbPRRVLDhbDhaDhb

antiSMASH-DB 4.0 matches for allorf_115697_115819

100.0%

NZ_KV804818.1and 1 other:

NZ_KV804818.1 Lanthipeptides: allorf_115697_115819_lanthipeptide

Lanthipeptides: allorf_115697_115819_lanthipeptide

WRIPGDISPEICGTPRRVLTST

30.0%

NC_018499.1and 1 other:

NC_018499.1 Lanthipeptides: BCK_RS27825_lanthipeptide

Lanthipeptides: BCK_RS27825_lanthipeptide

GDISPEICGTPRRVLT

GD++PEI TP V T

GDVNPEIAPTPHTVTT

29.2%

NZ_FUXI01000002.1:

Lanthipeptides: B5D30_RS01240_lanthipeptide

GDISPEICGTPRRVLTS

GD++P+ G+ LTS

GDVNPQTVGSLWEFLTS

with 9 more sequence matches

26.7%

NZ_MLKL01000042.1:

Lanthipeptides: BKK45_RS27420_lanthipeptide

GDISPEICGTPRRVLT

GD++PE TP V T

GDVNPETAPTPHTVTT

25.0%

NZ_JACIJS010000004.1:

Lanthipeptides: allorf_030388_030501_lanthipeptide

GDISPEICGT

GD+SP +CG

GDLSPCVCGA

25.0%

NZ_QSIO01000003.1:

Lanthipeptides: DW820_RS07295_lanthipeptide

GDISPEICGTPRRVL

GDISPE TP VL

GDISPET--TPACVL

20.0%

NZ_CP075910.1and 3 others:

NZ_CP075971.1 Lanthipeptides: KLF29_RS14850_lanthipeptideNZ_CP075982.1 Lanthipeptides: KLF51_RS14900_lanthipeptideNZ_CP075994.1 Lanthipeptides: KLF26_RS16110_lanthipeptide

Lanthipeptides: KLF45_RS14835_lanthipeptide

WRIPGDISPEICGTPRRVLT

+ PG ++ E+CG+ LT

YCTPGCLTGELCGSSECGLT

17.6%

NZ_CABIWO010000014.1:

Lanthipeptides: FY209_RS17155_lanthipeptide

WRIPGDISPEICGTPRRVLT

+ PG ++ ++CG+ LT

YCTPGCVTGQLCGSSECGLT

17.1%

NC_018499.1and 1 other:

NC_018499.1 Lanthipeptides: BCK_RS27830_lanthipeptide

Lanthipeptides: BCK_RS27830_lanthipeptide

GDISPEICGTP

GD++PEI P

GDVNPEIMSDP

15.0%

NZ_JAFHCX010000012.1and 1 other:

NZ_LR738722.1 Lanthipeptides: STREPSUIS_RS04075_lanthipeptide

Lanthipeptides: JXW96_RS06965_lanthipeptide

GDISPE

14.6%

NZ_CP051486.1:

Lanthipeptides: allorf_6974648_6974821_lanthipeptide

RIPGDISPEICGT

R+PG + P CG

RVPGRVLPGRCGA

10.7%

NC_016582.1:

Lanthipeptides: allorf_10870098_10870307_lanthipeptide

CGTPRRVL

CGT RR+L

CGTSRRLL

allorf_115961_116155

Leader:

MVTSATIQVKVCTVGYGFRIHLYRQVKSLYS

Core:

PCLGQGRVSSPSNLHIILRPLSMFGVVIRKYFD

Core with dehydrations:

PCysLGQGRVDhaDhaPDhaNLHIILRPLDhaMFGVVIRKYFD

antiSMASH-DB 4.0 matches for allorf_115961_116155

100.0%

NZ_KV795763.1and 2 others:

NZ_KV804818.1 Lanthipeptides: allorf_115961_116155_lanthipeptideNZ_KV804818.1 Lanthipeptides: allorf_115961_116155_lanthipeptide

Lanthipeptides: allorf_249293_249487_lanthipeptide

PCLGQGRVSSPSNLHIILRPLSMFGVVIRKYFD

24.2%

NZ_BMUN01000001.1and 9 others:

Lanthipeptides: IE238_RS00870_lanthipeptide

LGQGRVSSPSNLHIILR

GQG +SPS+ I R

FGQGTFTSPSSYAIGTR

24.2%

NZ_CP043959.1and 8 others:

Lanthipeptides: F3L20_RS18420_lanthipeptide

LGQGRVSSPSNLHIILR

GQG +SPS+ I R

FGQGTYTSPSSYAIGTR

with 5 more sequence matches

24.2%

NZ_CP058273.1:

Lanthipeptides: AY578_RS00390_lanthipeptide

GQGRVSSPSNLHIILR

GQG +SPS+ I R

GQGTYTSPSSYAIGTR

21.2%

NZ_BEWD01000004.1and 5 others:

Lanthipeptides: Sru02f_RS16280_lanthipeptide

LGQGRVSSPSNLHIILR

G+G +SPS+ I R

FGEGTFTSPSSYAIGTR

21.2%

NZ_CP023699.1:

Lassopeptides: CP970_RS43860_lassopeptide

RPLSMFGVVIR

RPL FG+ IR

RPLDSFGLNIR

20.0%

NZ_CP067396.1:

Lanthipeptides: JHW41_RS12400_lanthipeptide

SSPSNLHIILRPLSM

+ PS H +LR LSM

TGPSGAHGLLRCLSM

13.3%

NZ_CP078093.1:

Lanthipeptides: KVH43_RS13030_lanthipeptide

HIILRPLSMFGVVIRKY

+ + PL+ + V+ RKY

NWTMNPLTCYTVLSRKY

allorf_117600_117668

Leader:

MSPYFQDLSLIHAA

Core:

LQTCLTKS

Core with dehydrations:

LQDhbCysLDhbKDha

antiSMASH-DB 4.0 matches for allorf_117600_117668

100.0%

NZ_KV795763.1and 2 others:

NZ_KV804818.1 Lanthipeptides: allorf_117600_117668_lanthipeptideNZ_KV804818.1 Lanthipeptides: allorf_117600_117668_lanthipeptide

Lanthipeptides: allorf_250932_251000_lanthipeptide

LQTCLTKS

allorf_117642_117731

Leader:

MFTLSGLNAWSGS

Core:

FLLIYSFHLAFCKTCL

Core with dehydrations:

FLLIYDhaFHLAFCysKDhbCysL

antiSMASH-DB 4.0 matches for allorf_117642_117731

100.0%

NZ_KV795763.1and 2 others:

NZ_KV804818.1 Lanthipeptides: allorf_117642_117731_lanthipeptideNZ_KV804818.1 Lanthipeptides: allorf_117642_117731_lanthipeptide

Lanthipeptides: allorf_250974_251063_lanthipeptide

FLLIYSFHLAFCKTCL

23.1%

NC_014483.2and 18 others:

Lanthipeptides: PPE_RS07020_lanthipeptide

FHLAFCKTC

L+FCKTC

VSLSFCKTC

23.1%

NC_023037.2and 11 others:

Lanthipeptides: X809_RS07820_lanthipeptide

FHLAFCKTC

L FCKTC

VSLTFCKTC

with 3 more sequence matches

19.2%

NZ_JAIFIS010000001.1:

Lanthipeptides: K1X09_RS26315_lanthipeptide

FHLAFCKTC

L+FC+TC

ISLSFCRTC

18.6%

NZ_QKUF01000009.1:

Lanthipeptides: allorf_200737_200904_lanthipeptide

LLIYSFHLAFCKTC

LLI SF FC+ C

LLIRSFSYNFCRQC

11.8%

NZ_BOSN01000007.1and 3 others:

Lanthipeptides: allorf_257698_257880_lanthipeptide

IYSFHLAFCKTC

+YSF++ C TC

LYSFYIHKCSTC

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.67 out of 26.06

Confidence: medium

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 21.09 out of 23.43

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.52 out of 27.55

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.68 out of 19.52

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.78 out of 20.97

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.73 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.60 out of 26.06

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.06 out of 23.79

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.20 out of 27.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19

Confidence: medium

Additional weak hits (16):

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 22.56 out of 32.93

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.74 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.11 out of 26.06

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.70 out of 26.12

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 20.41 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.95 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.59 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.02 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.06 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.53 out of 26.06

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.25 out of 30.22

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 20.61 out of 30.97

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 23.40 out of 30.98

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.79 out of 22.40

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 24.31 out of 32.93

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 21.52 out of 33.14

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

HMPREF2804_RS11135 - Class II

Cleavage pHMM score: -6.20

RODEO score: 0

Monoisotopic mass: 3348.6 Da

Molecular weight: 3350.8 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3368.8 Da N = 1; 3386.8 Da N = 2; 3404.8 Da N = 3; 3422.8 Da N = 4

HMPREF2804_RS09455 - Class II

Cleavage pHMM score: -6.80

RODEO score: 0

Monoisotopic mass: 2632.4 Da

Molecular weight: 2634.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2652.2 Da N = 1

allorf_083218_083325 - Class II

Cleavage pHMM score: -6.60

RODEO score: 0

Monoisotopic mass: 2930.5 Da

Molecular weight: 2932.4 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2950.4 Da N = 1

allorf_096778_096948 - Class II

Cleavage pHMM score: -7.30

RODEO score: 0

Monoisotopic mass: 4976.4 Da

Molecular weight: 4979.7 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 4997.8 Da N = 1; 5015.8 Da N = 2; 5033.8 Da N = 3; 5051.8 Da N = 4; 5069.8 Da N = 5; 5087.9 Da N = 6

allorf_097220_097294 - Class II

Cleavage pHMM score: -7.20

RODEO score: 0

Monoisotopic mass: 1357.7 Da

Molecular weight: 1358.7 Da

Number of bridges: 1

HMPREF2804_RS09455 - Class II

Cleavage pHMM score: -6.80

RODEO score: 0

Monoisotopic mass: 2632.4 Da

Molecular weight: 2634.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2652.2 Da N = 1

HMPREF2804_RS09475 - Class II

Cleavage pHMM score: -0.60

RODEO score: 0

Monoisotopic mass: 3513.4 Da

Molecular weight: 3515.5 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3533.6 Da N = 1; 3551.6 Da N = 2

HMPREF2804_RS11470 - Class II

Cleavage pHMM score: -0.60

RODEO score: 0

Monoisotopic mass: 3100.5 Da

Molecular weight: 3102.6 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3120.6 Da N = 1; 3138.7 Da N = 2

allorf_096778_096948 - Class II

Cleavage pHMM score: -7.30

RODEO score: 0

Monoisotopic mass: 4976.4 Da

Molecular weight: 4979.7 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 4997.8 Da N = 1; 5015.8 Da N = 2; 5033.8 Da N = 3; 5051.8 Da N = 4; 5069.8 Da N = 5; 5087.9 Da N = 6

allorf_097220_097294 - Class II

Cleavage pHMM score: -7.20

RODEO score: 0

Monoisotopic mass: 1357.7 Da

Molecular weight: 1358.7 Da

Number of bridges: 1

allorf_109292_109366 - Class II

Cleavage pHMM score: -4.80

RODEO score: 0

Monoisotopic mass: 1533.8 Da

Molecular weight: 1534.8 Da

Number of bridges: 1

allorf_109330_109521 - Class II

Cleavage pHMM score: -3.80

RODEO score: 0

Monoisotopic mass: 4251.3 Da

Molecular weight: 4253.9 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 4271.9 Da N = 1; 4289.9 Da N = 2

allorf_115697_115819 - Class II

Cleavage pHMM score: -6.80

RODEO score: 0

Monoisotopic mass: 2363.3 Da

Molecular weight: 2364.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2382.7 Da N = 1; 2400.7 Da N = 2; 2418.8 Da N = 3; 2436.8 Da N = 4

allorf_115961_116155 - Class II

Cleavage pHMM score: -5.20

RODEO score: 0

Monoisotopic mass: 3627.0 Da

Molecular weight: 3629.3 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3647.3 Da N = 1; 3665.3 Da N = 2; 3683.3 Da N = 3

allorf_117600_117668 - Class II

Cleavage pHMM score: -5.40

RODEO score: 0

Monoisotopic mass: 838.5 Da

Molecular weight: 839.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 857.0 Da N = 1; 875.0 Da N = 2

allorf_117642_117731 - Class II

Cleavage pHMM score: -7.00

RODEO score: 0

Monoisotopic mass: 1882.0 Da

Molecular weight: 1883.3 Da

Number of bridges: 2

HMPREF2804_RS09455 - Class II

Cleavage pHMM score: -6.80

RODEO score: 0

Monoisotopic mass: 2602.4 Da

Molecular weight: 2604.2 Da

Number of bridges: 0

Additional modifications: AviCys

Additional modifications: OH

Alternative weights: (assuming N unmodified Ser/Thr residues); 2622.2 Da N = 1

HMPREF2804_RS09475 - Class II

Cleavage pHMM score: -0.60

RODEO score: 0

Monoisotopic mass: 3483.4 Da

Molecular weight: 3485.5 Da

Number of bridges: 1

Additional modifications: AviCys

Additional modifications: OH

Alternative weights: (assuming N unmodified Ser/Thr residues); 3503.6 Da N = 1; 3521.6 Da N = 2

HMPREF2804_RS11470 - Class II

Cleavage pHMM score: -0.60

RODEO score: 0

Monoisotopic mass: 3070.5 Da

Molecular weight: 3072.6 Da

Number of bridges: 2

Additional modifications: AviCys

Additional modifications: OH

Alternative weights: (assuming N unmodified Ser/Thr residues); 3090.6 Da N = 1; 3108.7 Da N = 2

HMPREF2804_RS11475 - Class II

Cleavage pHMM score: -1.80

RODEO score: 0

Monoisotopic mass: 3354.6 Da

Molecular weight: 3356.9 Da

Number of bridges: 1

Additional modifications: AviCys

Additional modifications: OH

Alternative weights: (assuming N unmodified Ser/Thr residues); 3374.9 Da N = 1; 3392.9 Da N = 2; 3410.9 Da N = 3; 3429.0 Da N = 4

allorf_109292_109366 - Class II

Cleavage pHMM score: -4.80

RODEO score: 0

Monoisotopic mass: 1503.8 Da

Molecular weight: 1504.8 Da

Number of bridges: 0

Additional modifications: AviCys

Additional modifications: OH

allorf_109330_109521 - Class II

Cleavage pHMM score: -3.80

RODEO score: 0

Monoisotopic mass: 4221.3 Da

Molecular weight: 4223.9 Da

Number of bridges: 0

Additional modifications: AviCys

Additional modifications: OH

Alternative weights: (assuming N unmodified Ser/Thr residues); 4241.9 Da N = 1; 4259.9 Da N = 2

allorf_115697_115819 - Class II

Cleavage pHMM score: -6.80

RODEO score: 0

Monoisotopic mass: 2333.3 Da

Molecular weight: 2334.7 Da

Number of bridges: 0

Additional modifications: AviCys

Additional modifications: OH

Alternative weights: (assuming N unmodified Ser/Thr residues); 2352.7 Da N = 1; 2370.7 Da N = 2; 2388.8 Da N = 3; 2406.8 Da N = 4

allorf_115961_116155 - Class II

Cleavage pHMM score: -5.20

RODEO score: 0

Monoisotopic mass: 3597.0 Da

Molecular weight: 3599.3 Da

Number of bridges: 0

Additional modifications: AviCys

Additional modifications: OH

Alternative weights: (assuming N unmodified Ser/Thr residues); 3617.3 Da N = 1; 3635.3 Da N = 2; 3653.3 Da N = 3

allorf_117600_117668 - Class II

Cleavage pHMM score: -5.40

RODEO score: 0

Monoisotopic mass: 808.5 Da

Molecular weight: 809.0 Da

Number of bridges: 0

Additional modifications: AviCys

Additional modifications: OH

Alternative weights: (assuming N unmodified Ser/Thr residues); 827.0 Da N = 1; 845.0 Da N = 2

allorf_117642_117731 - Class II

Cleavage pHMM score: -7.00

RODEO score: 0

Monoisotopic mass: 1852.0 Da

Molecular weight: 1853.3 Da

Number of bridges: 1

Additional modifications: AviCys

Additional modifications: OH

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
BldD	Development and antibiotic global regulator
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM	Regulator of nitrogen-fixation genes
IolR	Regulator of the inositol catabolism
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor