GCF_001635915.1 - 17 region(s)

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Location: 414,928 - 458,509 nt. (total: 43,582 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidase

WR47_RS02155: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

Transferases: phosphorylase phosphotransferase

WR47_RS02165: Glucose-specific phosphotransferase enzyme IIA

smcogs: SMCOG1145: Glucose-specific phosphotransferase enzyme IIA

WR47_RS02190: thiamine-phosphate pyrophosphorylase

smcogs: SMCOG1280: thiamine-phosphate pyrophosphorylase

Hydrolases: glucosidase

WR47_RS02160: Alpha-glucosidase

smcogs: SMCOG1257: Alpha-glucosidase

Ligases: ligase

WR47_RS02205: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.61	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000307.4	0.60	NRPS	AbT1	Aureobasidium pullulans
BGC0001132.4	0.60	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001166.5	0.60	NRPS	HC-toxin	Alternaria jesenskae
BGC0001128.4	0.60	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.60	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3	0.60	NRPS	AM-toxin	Alternaria alternata
BGC0001250.4	0.60	NRPS	epichloenin A	Epichloe festucae
BGC0001251.4	0.60	NRPS	epichloenin A	Epichloe festucae
BGC0001758.4	0.59	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.61	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000307.4	0.60	NRPS	AbT1	Aureobasidium pullulans
BGC0001132.4	0.60	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001166.5	0.60	NRPS	HC-toxin	Alternaria jesenskae
BGC0001128.4	0.60	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.60	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3	0.60	NRPS	AM-toxin	Alternaria alternata
BGC0001250.4	0.60	NRPS	epichloenin A	Epichloe festucae
BGC0001251.4	0.60	NRPS	epichloenin A	Epichloe festucae
BGC0001758.4	0.59	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.69 out of 21.55

Confidence: strong

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 25.04 out of 26.12

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.83 out of 27.78

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.81 out of 20.97

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.18 out of 23.79

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.96 out of 20.97

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 22.91 out of 25.88

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 22.91 out of 25.88

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.69 out of 27.55

Confidence: medium

Additional weak hits (10):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.78 out of 31.73

Confidence: weak

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.11 out of 20.47

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.95 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.17 out of 32.74

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.89 out of 30.25

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.70 out of 25.75

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.13 out of 25.88

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.13 out of 25.88

Confidence: weak

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.06 out of 29.72

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.98 out of 33.14

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 414927 - 458509:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

WR47_RS02205: X

AMP-binding (225..621): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LWMPFDASVWEAALAIGGEHNVYGPTECTVVTTT
Nearest Stachelhaus code(s):: Leu DAWYLGNVVK (71% 8Å match)
Stachelhaus code match:: 70% (weak)

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM	Regulator of nitrogen-fixation genes
IolR	Regulator of the inositol catabolism
LuxO	Repressor of luminescence
PsrA	Oleic acid responsive regulator

NZ_CP011151.1 - Region 2 - NRPS,transAT-PKS

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Location: 537,576 - 611,705 nt. (total: 74,130 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: PPTase acylase acyltransferase

WR47_RS02840: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

WR47_RS02855: polyketide synthase associated protein papA3

smcogs: SMCOG1209: polyketide synthase associated protein papA3

WR47_RS02860: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: esterase

WR47_RS02845: thioesterase

smcogs: SMCOG1004: thioesterase

Lyases: cyclase

WR47_RS02820: diguanylate cyclase

smcogs: SMCOG1025: diguanylate cyclase

Ligases: ligase synthase

WR47_RS02850: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

WR47_RS02865: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

WR47_RS02870: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.86	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.83	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001833.4	0.78	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001758.4	0.77	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001128.4	0.77	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.77	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.75	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000307.4	0.71	NRPS	AbT1	Aureobasidium pullulans
BGC0001825.4	0.71	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001641.4	0.69	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.75	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.74	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.72	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.72	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.72	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001758.4	0.72	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001133.4	0.71	NRPS	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002071.2	0.70	NRPS	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0001166.5	0.70	NRPS	HC-toxin	Alternaria jesenskae

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 25.42 out of 26.06

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.33 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.63 out of 27.78

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 28.43 out of 29.38

Confidence: strong

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 24.43 out of 24.78

Confidence: strong

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.73 out of 28.19

Confidence: strong

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.28 out of 19.52

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.67 out of 25.31

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.94 out of 25.31

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.33 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.19 out of 29.38

Confidence: medium

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.68 out of 28.14

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.23 out of 27.78

Confidence: medium

Additional weak hits (8):

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 20.16 out of 29.72

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 26.40 out of 36.54

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.88 out of 27.55

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 16.99 out of 30.12

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 17.35 out of 30.12

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.47 out of 26.85

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.53 out of 29.25

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.41 out of 29.65

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 2, location 537575 - 611705:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Leu - D-Val) + (Asp - Thr - Leu - Val - Leu) + (ccmal) + (ccmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 537575 - 600831:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Leu - D-Val) + (Asp - Thr - Leu - Val - Leu) + (ccmal) + (ccmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 560831 - 611705:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Leu - D-Val) + (Asp - Thr - Leu - Val - Leu) + (ccmal) + (ccmal)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

WR47_RS02850: Leu - Val

Search NORINE for peptide: strict or relaxed

AMP-binding (275..658): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: LWAVFDPWALEPALITGGDFNNYGPTEHTVVTTN
Nearest Stachelhaus code(s):: Trp DAACIGNVVK (68% 8Å match); Leu DALLIGAVVK (47% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (1300..1703): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: VDTAFDGSTFDGFVIVGGDINGYGPTESTVFATA
Nearest Stachelhaus code(s):: Val DGFFVGGVFK (65% 8Å match)
Stachelhaus code match:: 90% (moderate)

WR47_RS02855: Asp - Thr - Leu - Val - Leu

Search NORINE for peptide: strict or relaxed

AMP-binding (470..875): Asp

nrpys: Asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asp (Asp)

Stachelhaus prediction details:

Stachelhaus sequence:: YWFSFDLGYTSSKLVLGGEMNHYGPTETTIGAIA
Nearest Stachelhaus code(s):: Asp DLTKVGHIGK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1517..1922): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LATHFDFSVWEGNQIFGGEVNMYGITETTVHVTY
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2564..2947): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: LWHAFDASSWEPFLLTGGDFNNYGPTENTVVTTT
Nearest Stachelhaus code(s):: Leu DAWFLGNVVK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3589..3992): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: VDTAFDGSTFDGFVIVGGDINGYGPTESTVFATA
Nearest Stachelhaus code(s):: Val DGFFVGGVFK (65% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (4634..5017): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: LWHAFDASSWEPFLLTGGDFNNYGPTENTVVTTT
Nearest Stachelhaus code(s):: Leu DAWFLGNVVK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

WR47_RS02860: mal

PKS_AT (6..290): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 105.0
inactive: 43.4
Methoxymalonyl-CoA: 41.1
Methylmalonyl-CoA: 36.2
Ethylmalonyl-CoA: 23.1
Propionyl-CoA: 15.3
2-Methylbutyryl-CoA: 11.3
fatty_acid: 11.2
Benzoyl-CoA: 9.3
Isobutyryl-CoA: 8.9
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
CatR	H2O2-responsive repressor
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1	Ferric Uptake Regulator
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
PerR	Peroxide regulator
ZuR variant 1	Zinc-responsive repressor

NZ_CP011151.1 - Region 3 - azole-containing-RiPP

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Location: 1,297,150 - 1,320,656 nt. (total: 23,507 nt) Show pHMM detection rules used

azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Azole RiPPs

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

WR47_RS06355: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: methyltransferase

WR47_RS06370: methyltransferase

smcogs: SMCOG1089: methyltransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002013.4	0.46	ribosomal	curacozole	Streptomyces curacoi
BGC0001174.4	0.44	ribosomal	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0000607.5	0.43	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0001146.5	0.43	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0001535.3	0.43	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001534.3	0.41	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001173.5	0.41	ribosomal	plantazolicin	Bacillus pumilus ATCC 7061
BGC0001145.5	0.40	ribosomal	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0000603.5	0.39	ribosomal	cyclothiazomycin	Streptomyces hygroscopicus
BGC0000606.5	0.39	ribosomal	lactazole	Streptomyces lactacystinaeus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002013.4	0.46	ribosomal	curacozole	Streptomyces curacoi
BGC0001174.4	0.44	ribosomal	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0000607.5	0.43	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0001146.5	0.43	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0001535.3	0.43	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001534.3	0.41	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001173.5	0.41	ribosomal	plantazolicin	Bacillus pumilus ATCC 7061
BGC0001145.5	0.40	ribosomal	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0000603.5	0.39	ribosomal	cyclothiazomycin	Streptomyces hygroscopicus
BGC0000606.5	0.39	ribosomal	lactazole	Streptomyces lactacystinaeus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.11 out of 27.55

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.04 out of 23.79

Confidence: medium

Additional weak hits (3):

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.62 out of 29.25

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.69 out of 39.62

Confidence: weak

(Thi)azol(in)e containing peptide predictions

No core peptides found.

RREFinder

TFBS Finder

Azole RiPPs

RRE predictions

: RRE type: Heterocycloanthracin_C_RRE; Location: 0 - 100; Score: 181.5; RRE type: Thiopeptide_F_RRE; Location: 10 - 89; Score: 41.0

TFBS definitions

Regulator	Description
GnfM	Regulator of nitrogen-fixation genes
IolR	Regulator of the inositol catabolism

Core peptide predictions

No core peptides found.

NZ_CP011151.1 - Region 4 - NI-siderophore

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Location: 1,933,709 - 1,965,416 nt. (total: 31,708 nt) Show pHMM detection rules used

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

WR47_RS09725: aminotransferase

smcogs: SMCOG1019: aminotransferase

Hydrolases: deacetylase

WR47_RS09660: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

Ligases: ligase synthase

WR47_RS09620: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

WR47_RS09690: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000942.4	0.89	other (other)	petrobactin	Bacillus anthracis str. Ames
BGC0002469.2	0.54	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0001572.3	0.51	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0000295.5	0.51	NRPS	acinetoferrin	Acinetobacter haemolyticus
BGC0002692.2	0.50	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0002620.2	0.50	other (other)	fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4	Fulvivirga marina
BGC0001531.5	0.50	other (other)	bisucaberin B	Tenacibaculum mesophilum
BGC0002305.2	0.50	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0002464.3	0.48	other (other)	alcaligin	Bordetella pertussis Tohama I
BGC0002633.2	0.47	other (other)	schizokinen	Leptolyngbya sp. PCC 7376

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000942.4	0.89	other (other)	petrobactin	Bacillus anthracis str. Ames
BGC0002469.2	0.54	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0001572.3	0.51	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0000295.5	0.51	NRPS	acinetoferrin	Acinetobacter haemolyticus
BGC0002692.2	0.50	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0002620.2	0.50	other (other)	fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4	Fulvivirga marina
BGC0001531.5	0.50	other (other)	bisucaberin B	Tenacibaculum mesophilum
BGC0002305.2	0.50	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0002464.3	0.48	other (other)	alcaligin	Bordetella pertussis Tohama I
BGC0002633.2	0.47	other (other)	schizokinen	Leptolyngbya sp. PCC 7376

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.14 out of 29.38

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.03 out of 20.97

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.38 out of 29.38

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.93 out of 28.19

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 15.13 out of 18.16

Confidence: strong

Additional weak hits (4):

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.58 out of 19.52

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.50 out of 32.74

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.66 out of 32.74

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.60 out of 36.54

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CcpA	Catabolite control protein A
FuR variant 1	Ferric Uptake Regulator
ZuR variant 1	Zinc-responsive repressor

NZ_CP011151.1 - Region 5 - NRP-metallophore,NRPS

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Location: 2,256,093 - 2,307,841 nt. (total: 51,749 nt) Show pHMM detection rules used

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidase oxygenase

WR47_RS11300: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

WR47_RS11305: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

WR47_RS11310: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

WR47_RS11365: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

WR47_RS11445: Antibiotic biosynthesis monooxygenase

smcogs: SMCOG1258: Antibiotic biosynthesis monooxygenase

WR47_RS11475: pyruvate oxidase/decarboxylase

smcogs: SMCOG1055: pyruvate oxidase/decarboxylase

Transferases: PPTase

WR47_RS11400: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: hydrolase protease

WR47_RS11380: isochorismatase

smcogs: SMCOG1027: isochorismatase

WR47_RS11425: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: hydratase

WR47_RS11320: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Isomerases: isomerase

WR47_RS11370: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase synthase

WR47_RS11375: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

WR47_RS11385: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

WR47_RS11450: Pseudouridine synthase

smcogs: SMCOG1154: Pseudouridine synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.5	1.05	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000309.5	0.88	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5	0.86	NRPS	paenibactin	Paenibacillus elgii B69
BGC0002075.3	0.86	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000343.5	0.86	NRPS	enterobactin	Pseudomonas sp. J465
BGC0001132.4	0.77	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.74	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.74	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.72	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.5	0.80	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000309.5	0.75	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5	0.74	NRPS	paenibactin	Paenibacillus elgii B69
BGC0002075.3	0.74	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000343.5	0.74	NRPS	enterobactin	Pseudomonas sp. J465
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.69	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.13 out of 27.78

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.21 out of 30.25

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.83 out of 27.78

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.53 out of 26.06

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.40 out of 29.38

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.20 out of 32.93

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.59 out of 23.05

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.53 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.41 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.90 out of 29.38

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.62 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.57 out of 27.78

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.56 out of 29.38

Confidence: medium

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.57 out of 32.74

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 25.99 out of 30.25

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.21 out of 30.25

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.53 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19

Confidence: medium

Additional weak hits (7):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.83 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.49 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.05 out of 29.38

Confidence: weak

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.72 out of 18.46

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.54 out of 30.25

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.85 out of 36.53

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.35 out of 31.73

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 7, location 2256092 - 2307841:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

WR47_RS11375: diOH-Bz

Search NORINE for peptide: strict or relaxed

AMP-binding (31..435): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: SVSLYPMSSPGGALQVGGAQQVFGMAEGLVNYTR
Nearest Stachelhaus code(s):: diOH-Bz PMPAQGVVNK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

WR47_RS11385: Gly - Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (464..864): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FAMTFDISALELQALVGGETNLYGPTETTIWSTF
Nearest Stachelhaus code(s):: Gly DILQLGLIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1524..1937): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LATHFDFSVWEGNQVFGGEINMYGITETTVHVSY
Nearest Stachelhaus code(s):: Thr DFWNVGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
FuR variant 1	Ferric Uptake Regulator
FuR variant 2	Ferric Uptake Regulator
LexA variant 3	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

NZ_CP011151.1 - Region 6 - NRPS

Download region SVG

Location: 2,444,762 - 2,510,670 nt. (total: 65,909 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: PPTase acetyltransferase acyltransferase

WR47_RS12275: Chloramphenicol acetyltransferase

smcogs: SMCOG1156: Chloramphenicol acetyltransferase

WR47_RS12285: acyltransferase 3

smcogs: SMCOG1088: acyltransferase 3

WR47_RS12315: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: deacetylase esterase

WR47_RS12230: acetylornithine deacetylase

smcogs: SMCOG1247: acetylornithine deacetylase

WR47_RS12320: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: ligase

WR47_RS12300: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

WR47_RS12305: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

WR47_RS12310: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Translocases: permease

WR47_RS12355: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

WR47_RS12370: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.74	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001833.4	0.73	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001758.4	0.73	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001135.5	0.73	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001133.4	0.72	NRPS	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0001128.4	0.71	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.71	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001166.5	0.70	NRPS	HC-toxin	Alternaria jesenskae
BGC0001132.4	0.70	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002071.2	0.70	NRPS	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.74	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001833.4	0.73	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001758.4	0.73	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001135.5	0.73	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001133.4	0.72	NRPS	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0001128.4	0.71	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.71	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001166.5	0.70	NRPS	HC-toxin	Alternaria jesenskae
BGC0001132.4	0.70	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002071.2	0.70	NRPS	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.03 out of 26.06

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.21 out of 26.06

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.30 out of 26.06

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.34 out of 20.97

Confidence: medium

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 30.96 out of 36.54

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.01 out of 30.25

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.23 out of 26.06

Confidence: medium

Additional weak hits (5):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.74 out of 31.73

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.09 out of 29.38

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 25.64 out of 31.73

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.08 out of 36.54

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 17.58 out of 30.12

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 8, location 2444761 - 2510670:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Thr) + (X - Ala) + (Ser - Leu - D-X - Glu)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

WR47_RS12300: Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (457..866): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LSTHFDFSVWEGNQIFGGEINMYGITETTVHVTY
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

WR47_RS12305: X - Ala

Search NORINE for peptide: strict or relaxed

AMP-binding (466..870): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: YWMTFDVSVWEWQFFSGGETNFYGPTEATIYVNA
Nearest Stachelhaus code(s):: Glu DVWHFGRINK (71% 8Å match); Gln DAWQFGLIDK (65% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (1527..1919): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: MWATFDLSVFEVNTNLAGEYNLYGPSEDTTYSTY
Nearest Stachelhaus code(s):: Ala DLFNNALTYK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

WR47_RS12310: Ser - Leu - X - Glu

Search NORINE for peptide: strict or relaxed

AMP-binding (496..901): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSFWEWHFFTSGEINLYGPTEATVDVTY
Nearest Stachelhaus code(s):: Ser DVWHFSLVDK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1558..1945): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: MWHAFDSAVQEPFAITGGDINQYGPSENTVVTTD
Nearest Stachelhaus code(s):: Pro DVQFIAQVVK (56% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (2600..3000): X

nrpys: Gln, Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: glu (Glu)

Stachelhaus prediction details:

Stachelhaus sequence:: LGLAFDASIQQMDILVGGEYNVYGPTECTVDATC
Nearest Stachelhaus code(s):: Gln or Glu DAQDLGVVDK (88% 8Å match); Ile DAQDLGVVDK (85% 8Å match); Gln DAQDLGVVDK (79% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (4115..4515): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: glu (Glu)

Stachelhaus prediction details:

Stachelhaus sequence:: LGLAFDVSIQQMDMLVGGEYNVYGPTECTVDATC
Nearest Stachelhaus code(s):: Gln or Glu DAQDLGVVDK (85% 8Å match); Ile DAQDLGVVDK (82% 8Å match); Gln DAQDLGVVDK (76% 8Å match)
Stachelhaus code match:: 90% (moderate)

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
ColR	Phenol-responsive regulator
HgtR	Hydrogen-dependent regulator
MogR	Repressor of flagellar motility genes

NZ_CP011151.1 - Region 7 - betalactone

Download region SVG

Location: 2,565,364 - 2,590,602 nt. (total: 25,239 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

WR47_RS12620: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: acetyltransferase carboxylase transferase

WR47_RS12625: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

WR47_RS12645: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

WR47_RS12665: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

Lyases: hydratase

WR47_RS12640: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase

WR47_RS12635: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

WR47_RS12650: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002284.3	0.55	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000131.5	0.46	PKS	pyrrolomycin	Streptomyces sp. UC 11065
BGC0000706.3	0.46	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000234.5	0.43	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000623.3	0.42	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001226.4	0.42	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0001103.5	0.42	NRPS, PKS	mycosubtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000563.4	0.42	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002700.2	0.41	ribosomal	bacinapeptin	Bacillus nakamurai

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002284.3	0.55	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000131.5	0.46	PKS	pyrrolomycin	Streptomyces sp. UC 11065
BGC0000706.3	0.46	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000234.5	0.43	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000623.3	0.42	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001226.4	0.42	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0001103.5	0.42	NRPS, PKS	mycosubtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000563.4	0.42	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002700.2	0.41	ribosomal	bacinapeptin	Bacillus nakamurai

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.06 out of 19.26

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.51 out of 27.55

Confidence: medium

Additional weak hits (1):

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.65 out of 33.14

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
GnfM	Regulator of nitrogen-fixation genes
ToxT	Regulator of MSHA biosynthesis

NZ_CP011151.1 - Region 8 - RiPP-like

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Location: 2,646,263 - 2,656,586 nt. (total: 10,324 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

WR47_RS12950: aminotransferase

smcogs: SMCOG1019: aminotransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000896.5	0.29	other (other)	cycloserine	Streptomyces lavendulae subsp. lavendulae
BGC0000721.4	0.26	saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0000172.5	0.23	PKS	Basiliskamide A, Basiliskamide B	Brevibacillus laterosporus PE36
BGC0000381.5	0.23	NRPS	lichenysin	Bacillus licheniformis DSM 13 = ATCC 14580
BGC0000433.5	0.22	NRPS	surfactin	Bacillus velezensis FZB42
BGC0000455.6	0.22	NRPS, saccharide	vancomycin	Amycolatopsis orientalis HCCB10007 (ATCC43491)
BGC0002588.2	0.22	other (other)	enduracididine	uncultured bacterium
BGC0001233.5	0.22	NRPS	feglymycin	Streptomyces sp. DSM 11171
BGC0001461.5	0.21	NRPS	Actinoidin B	Amycolatopsis keratiniphila subsp. nogabecina
BGC0001459.5	0.21	NRPS	decaplanin	Amycolatopsis regifaucium

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000896.5	0.29	other (other)	cycloserine	Streptomyces lavendulae subsp. lavendulae
BGC0000721.4	0.26	saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0000172.5	0.23	PKS	Basiliskamide A, Basiliskamide B	Brevibacillus laterosporus PE36
BGC0000381.5	0.23	NRPS	lichenysin	Bacillus licheniformis DSM 13 = ATCC 14580
BGC0000433.5	0.22	NRPS	surfactin	Bacillus velezensis FZB42
BGC0000455.6	0.22	NRPS, saccharide	vancomycin	Amycolatopsis orientalis HCCB10007 (ATCC43491)
BGC0002588.2	0.22	other (other)	enduracididine	uncultured bacterium
BGC0001233.5	0.22	NRPS	feglymycin	Streptomyces sp. DSM 11171
BGC0001461.5	0.21	NRPS	Actinoidin B	Amycolatopsis keratiniphila subsp. nogabecina
BGC0001459.5	0.21	NRPS	decaplanin	Amycolatopsis regifaucium

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.24 out of 21.55

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.87 out of 32.93

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.30 out of 26.06

Confidence: medium

Additional weak hits (2):

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.27 out of 25.75

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 17.35 out of 30.12

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
LexA variant 3	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes

NZ_CP011151.1 - Region 9 - RiPP-like

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Location: 2,753,177 - 2,763,443 nt. (total: 10,267 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase

WR47_RS13560: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

Similar gene clusters

No matches found.

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (2):

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.40 out of 36.53

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.64 out of 32.74

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description

NZ_CP011151.1 - Region 10 - NRPS

Download region SVG

Location: 2,782,264 - 2,829,274 nt. (total: 47,011 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

WR47_RS13725: FAD dependent oxidoreductase

smcogs: SMCOG1103: FAD dependent oxidoreductase

WR47_RS13875: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: aminotransferase

WR47_RS13870: aminotransferase

smcogs: SMCOG1019: aminotransferase

Hydrolases: esterase glucanase hydrolase

WR47_RS13805: alpha/beta hydrolase domain-containing protein

smcogs: SMCOG1066: alpha/beta hydrolase domain-containing protein

WR47_RS13825: Pullulanase, type I

smcogs: SMCOG1297: Pullulanase, type I

WR47_RS13835: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

smcogs: SMCOG1283: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

WR47_RS13880: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

Lyases: decarboxylase

WR47_RS13810: Decarboxylase, pyridoxal-dependent

smcogs: SMCOG1180: Decarboxylase, pyridoxal-dependent

Ligases: ligase

WR47_RS13815: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001249.5	0.72	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001261.3	0.66	NRPS	AM-toxin	Alternaria alternata
BGC0001135.5	0.66	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.64	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.64	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.64	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4	0.63	NRPS	AbT1	Aureobasidium pullulans
BGC0002135.2	0.63	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000357.5	0.62	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001641.4	0.62	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001249.5	0.72	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001261.3	0.66	NRPS	AM-toxin	Alternaria alternata
BGC0001135.5	0.66	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.64	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.64	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.64	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4	0.63	NRPS	AbT1	Aureobasidium pullulans
BGC0002135.2	0.63	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000357.5	0.62	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001641.4	0.62	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.71 out of 26.33

Confidence: medium

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 24.13 out of 29.25

Confidence: medium

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 28.23 out of 31.73

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.81 out of 20.97

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.75 out of 28.19

Confidence: medium

Additional weak hits (6):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.07 out of 32.74

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.69 out of 31.73

Confidence: weak

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 20.28 out of 29.72

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.46 out of 31.73

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.36 out of 33.73

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.63 out of 29.65

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 12, location 2782263 - 2829274:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - Cys)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

WR47_RS13815: X - Cys

Search NORINE for peptide: strict or relaxed

AMP-binding (266..656): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: FVMAFDISLLELESLLAGELNIYGPTETTICATV
Nearest Stachelhaus code(s):: Ala DILICALICK (44% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (1303..1683): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: TDISFDLSVYDGNTLHSGDISLGGATEASIWSIY
Nearest Stachelhaus code(s):: Cys DLYNLSLIWK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
CcpA	Catabolite control protein A
HexR	Glucose-responsive regulator
SypG	Regulator of biofilm formation and host colonization
ZuR variant 1	Zinc-responsive repressor

NZ_CP011151.1 - Region 11 - terpene

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Location: 3,604,760 - 3,626,613 nt. (total: 21,854 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

WR47_RS17720: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

WR47_RS17725: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Lyases: lyase

WR47_RS17695: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000917.3	0.52	other (other)	molybdenum cofactor	Rhodobacter capsulatus
BGC0000888.5	0.49	other (other)	bacilysin	Bacillus sp. CS93
BGC0001928.2	0.46	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000916.5	0.46	other (other)	molybdenum cofactor	Staphylococcus carnosus
BGC0000812.3	0.45	other (other)	huperzine A	Shiraia sp. slf14
BGC0000231.5	0.42	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001605.3	0.42	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001197.5	0.42	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000234.5	0.41	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002138.2	0.40	PKS	fuelimycin A, fuelimicin B, fuelimicin C	Streptomyces albireticuli NRRL B-1670

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000917.3	0.52	other (other)	molybdenum cofactor	Rhodobacter capsulatus
BGC0000888.5	0.49	other (other)	bacilysin	Bacillus sp. CS93
BGC0001928.2	0.46	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000916.5	0.46	other (other)	molybdenum cofactor	Staphylococcus carnosus
BGC0000812.3	0.45	other (other)	huperzine A	Shiraia sp. slf14
BGC0000231.5	0.42	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001605.3	0.42	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001197.5	0.42	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000234.5	0.41	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002138.2	0.40	PKS	fuelimycin A, fuelimicin B, fuelimicin C	Streptomyces albireticuli NRRL B-1670

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	hopanoid		C30	hopanoid skeleton	unknown
triterpene	polypodane		C30	polypodane skeleton	unknown

Genes with terpene domains:

WR47_RS17735: T2TS

Domain 1 (4 - 614): Type 2 terpene synthase

Subtype: Squalene substrate

Reactions:: squalene → hopanoid; squalene → polypodane

Transcription Factor Binding Sites

Binding sites found:

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 26.42 out of 30.22

Confidence: medium

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
ClgR	Caseinolytic protease gene regulator

NZ_CP011151.1 - Region 12 - lanthipeptide-class-i

BGC0000535.4 (ADJ56352.1):

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Location: 3,691,416 - 3,717,859 nt. (total: 26,444 nt) Show pHMM detection rules used

lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: protease

WR47_RS18105: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase dehydratase

WR47_RS18150: Lanthionine synthetase C family protein

smcogs: SMCOG1140: Lanthionine synthetase C family protein

WR47_RS18160: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002576.2	0.76	ribosomal	mechercharmycin	Thermoactinomyces sp.
BGC0000541.5	0.61	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000542.3	0.61	ribosomal	paenicidin B	Paenibacillus terrae
BGC0001289.5	0.60	ribosomal	penisin	Paenibacillus ehimensis
BGC0002668.2	0.56	ribosomal	cesin A	Clostridium estertheticum
BGC0002640.2	0.56	ribosomal	thalassomonasin A, thalassomonasin B	Thalassomonas actiniarum
BGC0002635.2	0.56	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa
BGC0001618.3	0.56	ribosomal	hyicin 3682	Staphylococcus hyicus
BGC0000560.5	0.55	ribosomal	subtilomycin	Bacillus subtilis
BGC0000506.4	0.55	ribosomal	entianin	Bacillus subtilis subsp. spizizenii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002576.2	0.76	ribosomal	mechercharmycin	Thermoactinomyces sp.
BGC0000541.5	0.61	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000542.3	0.61	ribosomal	paenicidin B	Paenibacillus terrae
BGC0001289.5	0.60	ribosomal	penisin	Paenibacillus ehimensis
BGC0002668.2	0.56	ribosomal	cesin A	Clostridium estertheticum
BGC0002640.2	0.56	ribosomal	thalassomonasin A, thalassomonasin B	Thalassomonas actiniarum
BGC0002635.2	0.56	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa
BGC0001618.3	0.56	ribosomal	hyicin 3682	Staphylococcus hyicus
BGC0000560.5	0.55	ribosomal	subtilomycin	Bacillus subtilis
BGC0000506.4	0.55	ribosomal	entianin	Bacillus subtilis subsp. spizizenii

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for WR47_RS18160

WR47_RS18165

Leader:

MINEKNLFDLDVQVTTATGDVDPQ

WR47_RS18170

Leader:

MINEKNLFDLDVQVTTATGDVDPQ

WR47_RS18175

Leader:

MINEKNLFDLDVQVTTATGDVDPQ

WR47_RS18180

Leader:

MINEKNLFDLDVQVTTATGDVDPQ

Shared core:

ITSISACTPGCGNTGSFNSFCC

Core with dehydrations:

IDhbDhaIDhaACysDhbPGCysGNDhbGDhaFNDhaFCysCys

antiSMASH-DB 4.0 matches for WR47_RS18165

100.0%

NC_022873.1and 92 others:

NZ_CM000742.1 Lanthipeptides: BMYCO0001_RS26515_lanthipeptideNZ_CP011151.1 Lanthipeptides: WR47_RS18180_lanthipeptideNZ_CP011151.1 Lanthipeptides: WR47_RS18175_lanthipeptideNZ_CP011151.1 Lanthipeptides: WR47_RS18170_lanthipeptideNZ_CP011151.1 Lanthipeptides: WR47_RS18165_lanthipeptideNZ_CP015350.1 Lanthipeptides: BT246_RS19775_lanthipeptideNZ_CP015350.1 Lanthipeptides: BT246_RS19770_lanthipeptideNZ_CP015350.1 Lanthipeptides: BT246_RS19765_lanthipeptideNZ_CP017060.1 Lanthipeptides: FORC47_RS18710_lanthipeptideNZ_CP017060.1 Lanthipeptides: FORC47_RS18705_lanthipeptideNZ_CP017060.1 Lanthipeptides: FORC47_RS18700_lanthipeptideNZ_CP026678.1 Lanthipeptides: C2I25_RS21370_lanthipeptideNZ_CP026678.1 Lanthipeptides: C2I25_RS21365_lanthipeptideNZ_CP026678.1 Lanthipeptides: C2I25_RS21360_lanthipeptideNZ_CP035965.1 Lanthipeptides: EXW35_RS16385_lanthipeptideNZ_CP035965.1 Lanthipeptides: EXW35_RS16380_lanthipeptideNZ_CP035994.1 Lanthipeptides: EXW32_RS16155_lanthipeptideNZ_CP035994.1 Lanthipeptides: EXW32_RS16150_lanthipeptideNZ_CP035994.1 Lanthipeptides: EXW32_RS16145_lanthipeptideNZ_CP035994.1 Lanthipeptides: EXW32_RS16140_lanthipeptideNZ_CP035999.1 Lanthipeptides: EXW27_RS26195_lanthipeptideNZ_CP035999.1 Lanthipeptides: EXW27_RS26190_lanthipeptideNZ_CP035999.1 Lanthipeptides: EXW27_RS26185_lanthipeptideNZ_CP035999.1 Lanthipeptides: EXW27_RS26180_lanthipeptideNZ_CP036099.1 Lanthipeptides: EXW47_RS16265_lanthipeptideNZ_CP036099.1 Lanthipeptides: EXW47_RS16260_lanthipeptideNZ_CP036099.1 Lanthipeptides: EXW47_RS16255_lanthipeptideNZ_CP036099.1 Lanthipeptides: EXW47_RS16250_lanthipeptideNZ_CP036117.1 Lanthipeptides: EXW43_RS16620_lanthipeptideNZ_CP036117.1 Lanthipeptides: EXW43_RS16615_lanthipeptideNZ_CP036117.1 Lanthipeptides: EXW43_RS16610_lanthipeptideNZ_CP036117.1 Lanthipeptides: EXW43_RS16605_lanthipeptideNZ_CP036145.1 Lanthipeptides: EXW57_RS16110_lanthipeptideNZ_CP036145.1 Lanthipeptides: EXW57_RS16105_lanthipeptideNZ_CP036145.1 Lanthipeptides: EXW57_RS16100_lanthipeptideNZ_CP036145.1 Lanthipeptides: EXW57_RS16095_lanthipeptideNZ_CP040334.1 Lanthipeptides: EUC39_RS14125_lanthipeptideNZ_CP040334.1 Lanthipeptides: EUC39_RS14120_lanthipeptideNZ_CP040334.1 Lanthipeptides: EUC39_RS14115_lanthipeptideNZ_CP045606.2 Lanthipeptides: GE376_RS18355_lanthipeptideNZ_CP045606.2 Lanthipeptides: GE376_RS18350_lanthipeptideNZ_CP045606.2 Lanthipeptides: GE376_RS18345_lanthipeptideNZ_CP047366.1 Lanthipeptides: GSN03_RS15835_lanthipeptideNZ_CP047366.1 Lanthipeptides: GSN03_RS15830_lanthipeptideNZ_CP071811.1 Lanthipeptides: EXW36_RS16415_lanthipeptideNZ_CP071811.1 Lanthipeptides: EXW36_RS16410_lanthipeptideNZ_CP071811.1 Lanthipeptides: EXW36_RS16405_lanthipeptideNZ_CP072061.1 Lanthipeptides: J5V93_RS15130_lanthipeptideNZ_CP072061.1 Lanthipeptides: J5V93_RS15125_lanthipeptideNZ_CP072061.1 Lanthipeptides: J5V93_RS15120_lanthipeptideNZ_CP084035.1 Lanthipeptides: LCF45_RS15990_lanthipeptideNZ_CP084035.1 Lanthipeptides: LCF45_RS15985_lanthipeptideNZ_CP084035.1 Lanthipeptides: LCF45_RS15980_lanthipeptideNZ_CP084035.1 Lanthipeptides: LCF45_RS15975_lanthipeptideNZ_CP093291.1 Lanthipeptides: MN093_RS25975_lanthipeptideNZ_CP093291.1 Lanthipeptides: MN093_RS25970_lanthipeptideNZ_CP093291.1 Lanthipeptides: MN093_RS25965_lanthipeptideNZ_CP093291.1 Lanthipeptides: MN093_RS25960_lanthipeptideNZ_CP093835.1 Lanthipeptides: MN034_RS15810_lanthipeptideNZ_CP093835.1 Lanthipeptides: MN034_RS15805_lanthipeptideNZ_CP093835.1 Lanthipeptides: MN034_RS15800_lanthipeptideNZ_CP093835.1 Lanthipeptides: MN034_RS15795_lanthipeptideNZ_JAIPUK010000008.1 Lanthipeptides: K9P71_RS24265_lanthipeptideNZ_JAIPUK010000008.1 Lanthipeptides: K9P71_RS24260_lanthipeptideNZ_JANCTB010000001.1 Lanthipeptides: NMG90_RS06155_lanthipeptideNZ_JANCTB010000001.1 Lanthipeptides: NMG90_RS06150_lanthipeptideNZ_JANCTB010000001.1 Lanthipeptides: NMG90_RS06145_lanthipeptideNZ_JANCTB010000001.1 Lanthipeptides: NMG90_RS06140_lanthipeptideNZ_JH792114.1 Lanthipeptides: II3_RS21535_lanthipeptideNZ_JH792114.1 Lanthipeptides: II3_RS21530_lanthipeptideNZ_JH792114.1 Lanthipeptides: II3_RS21525_lanthipeptideNZ_JH792251.1 Lanthipeptides: III_RS11095_lanthipeptideNZ_JH792251.1 Lanthipeptides: III_RS11090_lanthipeptideNZ_JH792251.1 Lanthipeptides: III_RS11085_lanthipeptideNZ_JH792251.1 Lanthipeptides: III_RS11080_lanthipeptideNZ_JH792251.1 Lanthipeptides: III_RS11075_lanthipeptideNZ_LDGT01000041.1 Lanthipeptides: ABE17_RS18900_lanthipeptideNZ_LDGT01000041.1 Lanthipeptides: ABE17_RS18895_lanthipeptideNZ_LDGT01000041.1 Lanthipeptides: ABE17_RS18890_lanthipeptideNZ_LDGT01000041.1 Lanthipeptides: ABE17_RS18885_lanthipeptideNZ_LDHL01000037.1 Lanthipeptides: ABD98_RS26430_lanthipeptideNZ_LDHL01000037.1 Lanthipeptides: ABD98_RS26425_lanthipeptideNZ_MOOL01000076.1 Lanthipeptides: BK733_RS27280_lanthipeptideNZ_MOOL01000076.1 Lanthipeptides: BK733_RS27275_lanthipeptideNZ_MOOL01000076.1 Lanthipeptides: BK733_RS27270_lanthipeptideNZ_MSTN01000016.1 Lanthipeptides: BVF97_RS28620_lanthipeptideNZ_NIUP01000011.1 Lanthipeptides: CEU84_RS08145_lanthipeptideNZ_NIUP01000011.1 Lanthipeptides: CEU84_RS08140_lanthipeptideNZ_NKAX01000026.1 Lanthipeptides: CE086_RS26165_lanthipeptideNZ_NKAX01000026.1 Lanthipeptides: CE086_RS26160_lanthipeptideNZ_NVGU01000011.1 Lanthipeptides: COL71_RS14760_lanthipeptideNZ_NVGU01000011.1 Lanthipeptides: COL71_RS14755_lanthipeptide

Lanthipeptides: YBT1518_RS19670_lanthipeptide

1

ITSISACTPGCGNTGSFNSFCC

22

ITSISACTPGCGNTGSFNSFCC

1

ITSISACTPGCGNTGSFNSFCC

22

95.5%

NC_022873.1:

Lanthipeptides: YBT1518_RS19675_lanthipeptide

1

ITSISACTPGCGNTGSFNSFCC

22

IT ISACTPGCGNTGSFNSFCC

1

ITRISACTPGCGNTGSFNSFCC

22

82.6%

NZ_CP047792.1and 1 other:

NZ_JAGSAY010000004.1 Lanthipeptides: KC186_RS06745_lanthipeptide

Lanthipeptides: E3S88_RS07345_lanthipeptide

1

ITSISACTPGCGNTGSFNSFCC

22

ITS S CTPGC NTGSFNSFCC

2

ITSHSLCTPGCANTGSFNSFCC

23

with 111 more sequence matches

Only the first 10 are displayed here.

81.8%

NC_006582.1and 6 others:

NZ_BOQQ01000001.1 Lanthipeptides: KI354_RS00530_lanthipeptideNZ_BOQS01000001.1 Lanthipeptides: KI364_RS00675_lanthipeptideNZ_CP019985.1 Lanthipeptides: BC8716_RS09795_lanthipeptideNZ_CP104963.1 Lanthipeptides: N7M99_RS07725_lanthipeptideNZ_FRBS01000002.1 Lanthipeptides: BUC05_RS08990_lanthipeptideNZ_JAODPB010000001.1 Lanthipeptides: N6H06_RS03040_lanthipeptide

Lanthipeptides: ABC_RS22115_lanthipeptide

1

ITSISACTPGCGNTGSFNSFCC

22

TS+S CTPGCG TGSFNSFCC

1

FTSVSFCTPGCGETGSFNSFCC

22

81.8%

NC_014023.1and 36 others:

NC_014023.1 Lanthipeptides: BMQ_RS27575_lanthipeptideNZ_CP018875.1 Lanthipeptides: BUW91_RS26425_lanthipeptideNZ_CP018875.1 Lanthipeptides: BUW91_RS26420_lanthipeptideNZ_CP028091.1 Lanthipeptides: C1N54_RS28075_lanthipeptideNZ_CP028091.1 Lanthipeptides: C1N54_RS28070_lanthipeptideNZ_CP028091.1 Lanthipeptides: C1N54_RS28065_lanthipeptideNZ_CP031776.1 Lanthipeptides: D0441_RS30140_lanthipeptideNZ_CP041065.1 Lanthipeptides: FJM50_RS01185_lanthipeptideNZ_CP041065.1 Lanthipeptides: FJM50_RS01180_lanthipeptideNZ_CP041065.1 Lanthipeptides: FJM50_RS01175_lanthipeptideNZ_CP048884.1 Lanthipeptides: BMG_RS27510_lanthipeptideNZ_CP058263.1 Lanthipeptides: HW576_RS26980_lanthipeptideNZ_CP058263.1 Lanthipeptides: HW576_RS26975_lanthipeptideNZ_CP058263.1 Lanthipeptides: HW576_RS26970_lanthipeptideNZ_CP085427.1 Lanthipeptides: LIT30_RS26985_lanthipeptideNZ_CP085427.1 Lanthipeptides: LIT30_RS26980_lanthipeptideNZ_CP085427.1 Lanthipeptides: LIT30_RS26975_lanthipeptideNZ_CP085432.1 Lanthipeptides: LIT34_RS27820_lanthipeptideNZ_CP085432.1 Lanthipeptides: LIT34_RS27815_lanthipeptideNZ_CP085432.1 Lanthipeptides: LIT34_RS27810_lanthipeptideNZ_JACJHT010000009.1 Lanthipeptides: HNP21_RS25635_lanthipeptideNZ_JACJHT010000009.1 Lanthipeptides: HNP21_RS25630_lanthipeptideNZ_JACJHT010000009.1 Lanthipeptides: HNP21_RS25625_lanthipeptideNZ_JAHHYI010000015.1 Lanthipeptides: KM925_RS26245_lanthipeptideNZ_JANIOE010000010.1 Lanthipeptides: NQ109_RS28075_lanthipeptideNZ_JANIOE010000010.1 Lanthipeptides: NQ109_RS28070_lanthipeptideNZ_JANIOE010000010.1 Lanthipeptides: NQ109_RS28065_lanthipeptideNZ_NKAQ01000005.1 Lanthipeptides: CE057_RS19640_lanthipeptideNZ_NKAQ01000005.1 Lanthipeptides: CE057_RS19635_lanthipeptideNZ_NTZG01000054.1 Lanthipeptides: CN510_RS18265_lanthipeptideNZ_NUIN01000020.1 Lanthipeptides: CN973_RS26930_lanthipeptideNZ_NUOI01000090.1 Lanthipeptides: COE08_RS30285_lanthipeptideNZ_NUOI01000090.1 Lanthipeptides: COE08_RS30280_lanthipeptideNZ_NUOQ01000009.1 Lanthipeptides: COE31_RS05925_lanthipeptideNZ_NUXL01000007.1 Lanthipeptides: COJ36_RS20885_lanthipeptideNZ_NUZS01000089.1 Lanthipeptides: COJ90_RS28785_lanthipeptide

Lanthipeptides: BMQ_RS27580_lanthipeptide

1

ITSISACTPGCGNTGSFNSFCC

22

ITS+S CTPGCG+TGS+NSFCC

1

ITSVSLCTPGCGDTGSWNSFCC

22

81.8%

NZ_FNNQ01000006.1and 2 others:

NZ_FNNQ01000006.1 Lanthipeptides: BLV90_RS07685_lanthipeptideNZ_FNNQ01000006.1 Lanthipeptides: BLV90_RS07680_lanthipeptide

Lanthipeptides: BLV90_RS07690_lanthipeptide

1

ITSISACTPGCGNTGSFNSFCC

22

ITS+S CTPGCG TGSFNS+CC

1

ITSVSLCTPGCGETGSFNSYCC

22

81.8%

NZ_FPAA01000016.1and 3 others:

NZ_FPAA01000016.1 Lanthipeptides: CHX35_RS15995_lanthipeptideNZ_FPAA01000016.1 Lanthipeptides: CHX35_RS15990_lanthipeptideNZ_FPAA01000016.1 Lanthipeptides: CHX35_RS15985_lanthipeptide

Lanthipeptides: CHX35_RS16000_lanthipeptide

1

ITSISACTPGCGNTGSFNSFCC

22

ITS+S CTPGCG+TGSFNS+CC

1

ITSVSLCTPGCGDTGSFNSYCC

22

81.8%

NZ_LELK01000004.1:

Lanthipeptides: AB986_RS12540_lanthipeptide

1

ITSISACTPGCGNTGSFNSFCC

22

ITS S CTPGCG TGSFNS+CC

1

ITSYSFCTPGCGETGSFNSYCC

22

78.3%

NC_003923.1and 9 others:

NC_009641.1 Lanthipeptides: NWMN_RS09635_lanthipeptideNZ_CP023076.1 Lanthipeptides: CJ017_RS08945_lanthipeptideNZ_CP054876.1 Lanthipeptides: HUW54_RS09150_lanthipeptideNZ_CP077098.1 Lanthipeptides: KSF82_RS09475_lanthipeptideNZ_CP092781.1 Lanthipeptides: ML436_RS08940_lanthipeptideNZ_CP102959.1 Lanthipeptides: NW979_RS08780_lanthipeptideNZ_CP102962.1 Lanthipeptides: NW971_RS09555_lanthipeptideNZ_LR133917.1 Lanthipeptides: ELZ45_RS09155_lanthipeptideNZ_LS483317.1 Lanthipeptides: DQL75_RS09700_lanthipeptide

Lanthipeptides: MW_RS09420_lanthipeptide

1

ITSISACTPGCGNTGSFNSFCC

22

ITS S CTPGC TGSFNSFCC

2

ITSHSLCTPGCAKTGSFNSFCC

23

78.3%

NZ_LR134304.1:

Lanthipeptides: EL116_RS09245_lanthipeptide

1

ITSISACTPGCGNTGSFNSFCC

22

ITS+ CTPGCG TGSFNSFCC

2

ITSVIGCTPGCGKTGSFNSFCC

23

77.3%

NZ_AP019791.1:

Lanthipeptides: RxyAA322_RS06460_lanthipeptide

1

ITSISACTPGCGNTGSFNSFCC

22

ITS S CTPGC TGSFNS+CC

1

ITSYSLCTPGCAKTGSFNSYCC

22

72.7%

NZ_QGTF01000010.1:

Lanthipeptides: BDW27_RS18560_lanthipeptide

1

ITSISACTPGCGNTGSFNSFCC

22

+TS+S CTPGC N G+FNSFCC

1

VTSVSVCTPGCEN-GTFNSFCC

21

70.8%

NZ_VKCY01000012.1:

Lanthipeptides: FNK43_RS09020_lanthipeptide

1

ITSISACTPGCGNTGSFNSFCC

22

ITS S CTPGC TGSFNS+CC

3

ITSFSLCTPGCAKTGSFNSYCC

24

MIBiG 4.0 matches for WR47_RS18165

35.3%

Lanthipeptide: nisin A

1

ITSISACTPGCGNTGSF

17

ITSIS CTPGC TG+

1

ITSISLCTPGC-KTGAL

16

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.05 out of 20.97

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.12 out of 20.97

Confidence: strong

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.81 out of 25.88

Confidence: medium

Additional weak hits (2):

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.71 out of 30.97

Confidence: weak

Lanthipeptides

RREFinder

TFBS Finder

Core peptide predictions

WR47_RS18165 - Class I

Cleavage pHMM score: 11.60

RODEO score: 33

Monoisotopic mass: 1996.9 Da

Molecular weight: 1998.3 Da

Number of bridges: 3

Additional modifications: AviCys

Alternative weights: (assuming N unmodified Ser/Thr residues); 2016.3 Da N = 1; 2034.3 Da N = 2; 2052.3 Da N = 3

WR47_RS18170 - Class I

Cleavage pHMM score: 11.60

RODEO score: 33

Monoisotopic mass: 1996.9 Da

Molecular weight: 1998.3 Da

Number of bridges: 3

Additional modifications: AviCys

Alternative weights: (assuming N unmodified Ser/Thr residues); 2016.3 Da N = 1; 2034.3 Da N = 2; 2052.3 Da N = 3

WR47_RS18175 - Class I

Cleavage pHMM score: 11.60

RODEO score: 33

Monoisotopic mass: 1996.9 Da

Molecular weight: 1998.3 Da

Number of bridges: 3

Additional modifications: AviCys

Alternative weights: (assuming N unmodified Ser/Thr residues); 2016.3 Da N = 1; 2034.3 Da N = 2; 2052.3 Da N = 3

WR47_RS18180 - Class I

Cleavage pHMM score: 11.60

RODEO score: 33

Monoisotopic mass: 1996.9 Da

Molecular weight: 1998.3 Da

Number of bridges: 3

Additional modifications: AviCys

Alternative weights: (assuming N unmodified Ser/Thr residues); 2016.3 Da N = 1; 2034.3 Da N = 2; 2052.3 Da N = 3

RRE predictions

: RRE type: Lanthipeptide_LanB_RRE; Location: 162 - 259; Score: 82.1

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
PsrA	Oleic acid responsive regulator

NZ_CP011151.1 - Region 13 - terpene-precursor

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Location: 4,262,648 - 4,283,538 nt. (total: 20,891 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carboxylase

WR47_RS21125: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase

WR47_RS21090: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

WR47_RS21095: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002219.2	0.39	terpene	(-)-(R)-nephthenol	Stereum hirsutum FP-91666 SS1
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002219.2	0.39	terpene	(-)-(R)-nephthenol	Stereum hirsutum FP-91666 SS1
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

WR47_RS21095: PT_FPPS_like

Domain 1 (32 - 295): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.49 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.66 out of 26.06

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.32 out of 25.88

Confidence: medium

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.28 out of 26.33

Confidence: medium

Additional weak hits (2):

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.73 out of 30.98

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.40 out of 33.14

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes
PsrA	Oleic acid responsive regulator

NZ_CP011152.1 - Region 1 - NRPS

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Location: 41,817 - 98,035 nt. (total: 56,219 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

WR47_RS27755: nucleotide sugar dehydrogenase

smcogs: SMCOG1152: nucleotide sugar dehydrogenase

Transferases: PPTase glycosyltransferase transferase

WR47_RS27750: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

WR47_RS27765: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

WR47_RS27785: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

WR47_RS32740: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: deaminase esterase

WR47_RS27820: ornithine cyclodeaminase

smcogs: SMCOG1158: ornithine cyclodeaminase

WR47_RS27840: thioesterase

smcogs: SMCOG1004: thioesterase

Lyases: dehydratase

WR47_RS27760: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: ligase synthase

WR47_RS27825: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

WR47_RS27845: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

WR47_RS27850: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

WR47_RS27855: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.77	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001833.4	0.77	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.76	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.75	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002075.3	0.74	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001825.4	0.74	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0002286.3	0.74	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.74	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001758.4	0.73	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001166.5	0.72	NRPS	HC-toxin	Alternaria jesenskae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.77	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001833.4	0.77	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.76	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.75	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002075.3	0.74	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001825.4	0.74	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0002286.3	0.74	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.74	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001758.4	0.73	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001166.5	0.72	NRPS	HC-toxin	Alternaria jesenskae

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.71 out of 29.38

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.10 out of 27.55

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.33 out of 18.16

Confidence: strong

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.49 out of 24.78

Confidence: medium

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 26.57 out of 33.14

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.73 out of 28.19

Confidence: medium

Additional weak hits (4):

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 20.52 out of 29.51

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 23.11 out of 29.65

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 16.52 out of 30.12

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 41816 - 98035:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (NH2 - Thr - X) + (Asn) + (Asn)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

WR47_RS27845: Asn

Search NORINE for peptide: strict or relaxed

AMP-binding (507..909): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: YWCSFDLTITGSKLVVGGEINEYGPTEAVVGCTN
Nearest Stachelhaus code(s):: Asn DLTKVGEVGK (76% 8Å match)
Stachelhaus code match:: 100% (strong)

WR47_RS27850: Asn

Search NORINE for peptide: strict or relaxed

AMP-binding (504..906): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: YWCSFDLTITGSKLVVGGEINEYGPTEAVVGCTN
Nearest Stachelhaus code(s):: Asn DLTKVGEVGK (76% 8Å match)
Stachelhaus code match:: 100% (strong)

WR47_RS27855: NH2 - Thr - X

Search NORINE for peptide: strict or relaxed

CAL_domain (168..484): NH2

minowa: NH2

Prediction, score:

NH2: 129.0
Acetyl-CoA: 45.2
AHBA: 12.8
fatty_acid: 1.5
shikimic_acid: 0.0

AMP-binding (1174..1580): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LAAHFDFSVWEGNQIFGGEINMYGITETTVHVTY
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2243..2651): X

nrpys: Dpr

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: HAKAFDVSVWQSETVLNGEINACGATESSDDVNH
Nearest Stachelhaus code(s):: Dpr DVWEMNADDK (68% 8Å match)
Stachelhaus code match:: 90% (moderate)

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
FuR variant 1	Ferric Uptake Regulator
GnfM	Regulator of nitrogen-fixation genes
LexA variant 2	Repressor of DNA damage response
ZuR variant 1	Zinc-responsive repressor
ZuR variant 2	Zinc-responsive repressor

NZ_CP011152.1 - Region 2 - RiPP-like

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Location: 255,137 - 267,356 nt. (total: 12,220 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001862.4	0.55	ribosomal	pallidocin	Aeribacillus pallidus
BGC0002674.2	0.52	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0000558.5	0.49	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000484.5	0.48	ribosomal	glycocin F	Lactobacillus plantarum
BGC0002586.2	0.47	ribosomal	ASM1	Lactiplantibacillus plantarum
BGC0001864.3	0.47	ribosomal	listeriocytocin	Listeria monocytogenes SLCC2540
BGC0001861.4	0.46	ribosomal	bacillicin BAG2O	Bacillus cereus BAG2O-1
BGC0001863.4	0.46	ribosomal, terpene	bacillicn CER074	Bacillus mycoides
BGC0000590.5	0.46	ribosomal	microcin N	Escherichia coli
BGC0000589.5	0.46	ribosomal	microcin M	Escherichia coli Nissle 1917

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001862.4	0.55	ribosomal	pallidocin	Aeribacillus pallidus
BGC0002674.2	0.52	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0000558.5	0.49	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000484.5	0.48	ribosomal	glycocin F	Lactobacillus plantarum
BGC0002586.2	0.47	ribosomal	ASM1	Lactiplantibacillus plantarum
BGC0001864.3	0.47	ribosomal	listeriocytocin	Listeria monocytogenes SLCC2540
BGC0001861.4	0.46	ribosomal	bacillicin BAG2O	Bacillus cereus BAG2O-1
BGC0001863.4	0.46	ribosomal, terpene	bacillicn CER074	Bacillus mycoides
BGC0000590.5	0.46	ribosomal	microcin N	Escherichia coli
BGC0000589.5	0.46	ribosomal	microcin M	Escherichia coli Nissle 1917

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.77 out of 20.97

Confidence: medium

TFBS Finder

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A

NZ_CP011152.1 - Region 3 - lanthipeptide-class-ii

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Location: 278,262 - 307,122 nt. (total: 28,861 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: protease

WR47_RS28800: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase

WR47_RS28805: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

WR47_RS28840: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000517.4	0.60	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000504.5	0.55	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000525.5	0.54	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000554.4	0.54	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000516.4	0.54	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000623.3	0.54	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001229.4	0.52	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0001210.5	0.50	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000520.5	0.49	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000500.5	0.49	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000517.4	0.60	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000504.5	0.55	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000525.5	0.54	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000554.4	0.54	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000516.4	0.54	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000623.3	0.54	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001229.4	0.52	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0001210.5	0.50	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000520.5	0.49	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000500.5	0.49	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for WR47_RS28805

WR47_RS28810

Leader:

MKNNSIMRFWKDPLYRMDLSSDERGNMPGS

Core:

PVGDSLEEIQGNELLNAVGAGDVQANTSTVQILTPRTPIISNTLGNKGHACTITKECQNMCN

Core with dehydrations:

PVGDDhaLEEIQGNELLNAVGAGDVQANDhbDhaDhbVQILDhbPRDhbPIIDhaNDhbLGNKGHACysDhbIDhbKECysQNMCysN

antiSMASH-DB 4.0 matches for WR47_RS28810

100.0%

NZ_CP011152.1and 1 other:

NZ_CP011152.1 Lanthipeptides: WR47_RS28810_lanthipeptide

Lanthipeptides: WR47_RS28810_lanthipeptide

1

PVGDSLEEIQGNELLNAVGAGDVQANTSTVQILTPRTPIISNTLGNKGHACTITKECQNMCN

62

PVGDSLEEIQGNELLNAVGAGDVQANTSTVQILTPRTPIISNTLGNKGHACTITKECQNMCN

1

PVGDSLEEIQGNELLNAVGAGDVQANTSTVQILTPRTPIISNTLGNKGHACTITKECQNMCN

62

84.4%

NZ_CP011152.1and 3 others:

NZ_CP011152.1 Lanthipeptides: WR47_RS28815_lanthipeptideNZ_CP011152.1 Lanthipeptides: WR47_RS28820_lanthipeptideNZ_CP011152.1 Lanthipeptides: WR47_RS28815_lanthipeptide

Lanthipeptides: WR47_RS28820_lanthipeptide

1

PVGDSLEEIQGNELLNAVGAGDVQANTSTVQI--LTPRTPIISNTLGNKGHACTITKECQNMCN

62

PVGDSLEEIQGNELLNAVGAGDVQANT+T+ + LT ++P ISNTLGNKGHACTITKECQNMCN

1

PVGDSLEEIQGNELLNAVGAGDVQANTNTIVVTQLTAKSPYISNTLGNKGHACTITKECQNMCN

64

30.6%

NZ_CP009288.1and 3 others:

NZ_CP009288.1 Lanthipeptides: PDUR_RS25150_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptide

Lanthipeptides: PDUR_RS25150_lanthipeptide

33

LTPRTPI-ISNTLGNKGHACTITKECQNMCN

62

LT T I IS TLGN G CT TKEC CN

6

LTTSTSILISMTLGNNGWVCTATKECMPSCN

36

with 112 more sequence matches

Only the first 10 are displayed here.

29.0%

NZ_JALGRP010000007.1and 1 other:

NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide

Lanthipeptides: MT347_RS12955_lanthipeptide

24

QANTSTVQILTPRTPIISNTLGNKGHACTITKECQNMCN

62

Q T+T+ LT +S GN G CT T ECQN CN

3

QGWTTTITSLTCYG--VSWVAGNNGQVCTATVECQNNCN

39

27.4%

NZ_BMFU01000012.1and 5 others:

NZ_BMFU01000012.1 Lanthipeptides: IEW26_RS25375_lanthipeptideNZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23855_lanthipeptideNZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23855_lanthipeptideNZ_VDYW01000008.1 Lanthipeptides: FS579_RS24445_lanthipeptideNZ_VDYW01000008.1 Lanthipeptides: FS579_RS24445_lanthipeptide

Lanthipeptides: IEW26_RS25375_lanthipeptide

21

GDVQANTSTVQILTPRTPIISNTLGNKGHACTITKECQNMCN

62

G Q V I + S +GN GH CT+T ECQ CN

1

GAAQPEWVEVIITSLACAAASYFMGNPGHVCTLTVECQKSCN

42

27.4%

NZ_CP009280.1and 1 other:

NZ_CP009280.1 Lanthipeptides: P40081_RS01820_lanthipeptide

Lanthipeptides: P40081_RS01820_lanthipeptide

33

LTPRTPI-ISNTLGNKGHACTITKECQNMCN

62

LT T I IS LGN G CT +KEC CN

6

LTTSTSIFISRGLGNDGWVCTWSKECMPSCN

36

27.4%

NZ_CP084530.1and 1 other:

NZ_CP084530.1 Lanthipeptides: LDO05_RS02075_lanthipeptide

Lanthipeptides: LDO05_RS02075_lanthipeptide

34

TPRTPIISNTLGNKGHACTITKECQNMCN

62

T T +SN LGN G CT+TKECQ CN

2

TTNTFTLSNYLGNNGGWCTLTKECQRSCN

30

27.4%

NZ_JACHKG010000014.1and 1 other:

NZ_JACHKG010000014.1 Lanthipeptides: allorf_027480_027638_lanthipeptide

Lanthipeptides: allorf_027480_027638_lanthipeptide

21

GDVQANTSTVQILTPRTPIISNTLGNKGHACTITKECQNMCN

62

G Q + V I + S +GN GH CT+T ECQ CN

1

GAAQPQWAEVIITSLACAAASYFMGNPGHVCTLTVECQKSCN

42

27.4%

NZ_LT985747.1and 1 other:

NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide

Lanthipeptides: C8268_RS00165_lanthipeptide

34

TPRTPIISNTLGNKGHACTITKECQNMCN

62

T T +S+ LGNKG CT+TKECQ CN

2

TTNTFTLSDYLGNKGGWCTLTKECQRSCN

30

25.8%

NZ_BJTV01000004.1and 1 other:

NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS10200_lanthipeptide

Lanthipeptides: TNCT1_RS10200_lanthipeptide

34

TPRTPIISNTLGNKGHACTITKECQNMCN

62

T T +S+ LGN G CT+TKECQ CN

2

TTNTFSLSDALGNHGGWCTLTKECQANCN

30

25.8%

NZ_BNBV01000031.1and 1 other:

NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22995_lanthipeptide

Lanthipeptides: IE286_RS22995_lanthipeptide

34

TPRTPIISNTLGNKGHACTITKECQNMCN

62

T T +S+ LGN G CT+TKECQ CN

2

TTNTFSLSDALGNSGGWCTLTKECQPNCN

30

25.8%

NZ_CM000756.1and 7 others:

NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS34475_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide

Lanthipeptides: BTHUR0011_RS34475_lanthipeptide

34

TPRTPIISNTLGNKGHACTITKECQNMC

61

T + IIS T GNKG CT T EC N C

9

TSTSIIISETFGNKGKVCTYTVECVNNC

36

25.8%

NZ_CP025249.1and 1 other:

NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide

Lanthipeptides: CWT12_RS00385_lanthipeptide

38

PIISNTLGNKGHACTITKECQNMCN

62

P +S LGN G+ CT+TKECQ MCN

3

PWLSRKLGNTGYVCTLTKECQRMCN

27

MIBiG 4.0 matches for WR47_RS28810

27.4%

Lanthipeptide: birimositide

34

TPRTPIISNTLGNKGHACTITKECQNMCN

62

T T +SN LGN G CT+TKECQ CN

2

TTNTFSLSNALGNNGGWCTLTKECQPNCN

30

22.6%

Lanthipeptide: haloduracin β or haloduracin α

40

ISNTLGNKGHACTITKECQNMCN

62

IS LGNKG CT+T EC CN

6

ISCRLGNKGAYCTLTVECMPSCN

28

12.9%

BGC0000582.4 (ADR72962.1):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

51

CTITKECQNMCN

62

CT++KECQ CN

28

CTLSKECQPNCN

39

with 1 more sequence matches

8.1%

Linaridin: cypemycin

34

TPRTPIISNTLGNKGHACTI

53

TP TP ++ + C +

2

TPATPTVAQFVIQGSTICLV

21

WR47_RS28815

Leader:

MKNNSIMRFWKDPLYRMDLSSDERGNMPGS

WR47_RS28820

Leader:

MKNNSIMRFWKDPLYRMDLSSDERGNMPGS

Shared core:

PVGDSLEEIQGNELLNAVGAGDVQANTNTIVVTQLTAKSPYISNTLGNKGHACTITKECQNMCN

Core with dehydrations:

PVGDDhaLEEIQGNELLNAVGAGDVQANDhbNDhbIVVDhbQLDhbAKDhaPYIDhaNDhbLGNKGHACysDhbIDhbKECysQNMCysN

antiSMASH-DB 4.0 matches for WR47_RS28815

100.0%

NZ_CP011152.1and 3 others:

NZ_CP011152.1 Lanthipeptides: WR47_RS28815_lanthipeptideNZ_CP011152.1 Lanthipeptides: WR47_RS28820_lanthipeptideNZ_CP011152.1 Lanthipeptides: WR47_RS28815_lanthipeptide

Lanthipeptides: WR47_RS28820_lanthipeptide

1

PVGDSLEEIQGNELLNAVGAGDVQANTNTIVVTQLTAKSPYISNTLGNKGHACTITKECQNMCN

64

PVGDSLEEIQGNELLNAVGAGDVQANTNTIVVTQLTAKSPYISNTLGNKGHACTITKECQNMCN

1

PVGDSLEEIQGNELLNAVGAGDVQANTNTIVVTQLTAKSPYISNTLGNKGHACTITKECQNMCN

64

84.4%

NZ_CP011152.1and 1 other:

NZ_CP011152.1 Lanthipeptides: WR47_RS28810_lanthipeptide

Lanthipeptides: WR47_RS28810_lanthipeptide

1

PVGDSLEEIQGNELLNAVGAGDVQANTNTIVVTQLTAKSPYISNTLGNKGHACTITKECQNMCN

64

PVGDSLEEIQGNELLNAVGAGDVQANT+T+ + LT ++P ISNTLGNKGHACTITKECQNMCN

1

PVGDSLEEIQGNELLNAVGAGDVQANTSTVQI--LTPRTPIISNTLGNKGHACTITKECQNMCN

62

28.1%

NZ_CP009280.1and 1 other:

NZ_CP009280.1 Lanthipeptides: P40081_RS01820_lanthipeptide

Lanthipeptides: P40081_RS01820_lanthipeptide

26

NTNTIVVTQLTAKSPYISNTLGNKGHACTITKECQNMCN

64

+TNT+ T+ S +IS LGN G CT +KEC CN

2

DTNTLT----TSTSIFISRGLGNDGWVCTWSKECMPSCN

36

with 111 more sequence matches

Only the first 10 are displayed here.

28.1%

NZ_CP009288.1and 3 others:

NZ_CP009288.1 Lanthipeptides: PDUR_RS25150_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptide

Lanthipeptides: PDUR_RS25150_lanthipeptide

33

TQLTAKSPYISNTLGNKGHACTITKECQNMCN

64

T T+ S IS TLGN G CT TKEC CN

5

TLTTSTSILISMTLGNNGWVCTATKECMPSCN

36

28.1%

NZ_JALIRS010000003.1and 3 others:

NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07255_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide

Lanthipeptides: MOK21_RS07255_lanthipeptide

29

TIVVTQLTAKSPYISNTLGNKGHACTITKECQNMCN

64

TI+ + A + YI LGN GH CT+T ECQ CN

8

TILTSLACAAASYI---LGNPGHVCTLTVECQKKCN

40

26.6%

NZ_BMFU01000012.1and 5 others:

NZ_BMFU01000012.1 Lanthipeptides: IEW26_RS25375_lanthipeptideNZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23855_lanthipeptideNZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23855_lanthipeptideNZ_VDYW01000008.1 Lanthipeptides: FS579_RS24445_lanthipeptideNZ_VDYW01000008.1 Lanthipeptides: FS579_RS24445_lanthipeptide

Lanthipeptides: IEW26_RS25375_lanthipeptide

21

GDVQANTNTIVVTQLTAKSPYISNTLGNKGHACTITKECQNMCN

64

G Q +++T L + S +GN GH CT+T ECQ CN

1

GAAQPEWVEVIITSLACAAA--SYFMGNPGHVCTLTVECQKSCN

42

26.6%

NZ_CM000756.1and 7 others:

NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS34475_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide

Lanthipeptides: BTHUR0011_RS34475_lanthipeptide

33

TQLTAKSPYISNTLGNKGHACTITKECQNMC

63

T T+ S IS T GNKG CT T EC N C

6

TTATSTSIIISETFGNKGKVCTYTVECVNNC

36

26.6%

NZ_CP017953.1and 27 others:

NZ_CP017953.1 Lanthipeptides: BAMY_RS16400_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptideNZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptideNZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptideNZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptideNZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptideNZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptideNZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptideNZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptideNZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptideNZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptideNZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptideNZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptideNZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptide

Lanthipeptides: BAMY_RS16400_lanthipeptide

28

NTIVVTQLTAKSPYISNTLGNKGHACTITKECQNMC

63

NT T + +S LGNKG CT TKECQ C

2

NTWNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

26.6%

NZ_JACHKG010000014.1and 1 other:

NZ_JACHKG010000014.1 Lanthipeptides: allorf_027480_027638_lanthipeptide

Lanthipeptides: allorf_027480_027638_lanthipeptide

21

GDVQANTNTIVVTQLTAKSPYISNTLGNKGHACTITKECQNMCN

64

G Q +++T L + S +GN GH CT+T ECQ CN

1

GAAQPQWAEVIITSLACAAA--SYFMGNPGHVCTLTVECQKSCN

42

26.6%

NZ_JALGRP010000007.1and 1 other:

NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide

Lanthipeptides: MT347_RS12955_lanthipeptide

29

TIVVTQLTAKSPYISNTLGNKGHACTITKECQNMCN

64

T +T LT +S GN G CT T ECQN CN

6

TTTITSLTCYG--VSWVAGNNGQVCTATVECQNNCN

39

25.0%

NZ_BMRY01000003.1and 24 others:

NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide

Lanthipeptides: IE140_RS12370_lanthipeptide

29

TIVVTQLTAKSPYISNTLGNKGHACTITKECQNMC

63

TIV + + Y+ LGN G+ CT T ECQN C

6

TIVSSLSCYGASYV---LGNNGNFCTATAECQNNC

37

25.0%

NZ_CKMQ01000043.1and 10 others:

NZ_CKMQ01000043.1 Lanthipeptides: AE832_RS11585_lanthipeptideNZ_CKMR01000002.1 Lanthipeptides: AD782_RS11690_lanthipeptideNZ_CKMR01000002.1 Lanthipeptides: AD782_RS11690_lanthipeptideNZ_FIXU01000003.1 Lanthipeptides: A1M11_RS11670_lanthipeptideNZ_FIXU01000003.1 Lanthipeptides: A1M11_RS11670_lanthipeptideNZ_LR216041.1 Lanthipeptides: E0F00_RS05465_lanthipeptideNZ_LR216046.1 Lanthipeptides: E0E82_RS05980_lanthipeptideNZ_LR216046.1 Lanthipeptides: E0E82_RS05980_lanthipeptideNZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00170_lanthipeptideNZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00170_lanthipeptide

Lanthipeptides: AE832_RS11585_lanthipeptide

37

AKSPYISNTLGNKGHACTITKECQNMCN

64

A+ +IS LGNKG CT T ECQN C

3

AQLSFISEALGNKGAVCTGTIECQNNCR

30

25.0%

NZ_CP025249.1and 1 other:

NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide

Lanthipeptides: CWT12_RS00385_lanthipeptide

40

PYISNTLGNKGHACTITKECQNMCN

64

P++S LGN G+ CT+TKECQ MCN

3

PWLSRKLGNTGYVCTLTKECQRMCN

27

MIBiG 4.0 matches for WR47_RS28815

23.4%

Lanthipeptide: birimositide

42

ISNTLGNKGHACTITKECQNMCN

64

+SN LGN G CT+TKECQ CN

8

LSNALGNNGGWCTLTKECQPNCN

30

21.9%

Lanthipeptide: haloduracin β or haloduracin α

42

ISNTLGNKGHACTITKECQNMCN

64

IS LGNKG CT+T EC CN

6

ISCRLGNKGAYCTLTVECMPSCN

28

12.5%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

53

CTITKECQNMCN

64

CT++KECQ CN

28

CTLSKECQPNCN

39

WR47_RS28825

Leader:

MSKNEVKSLRDPKMRTEDFNNPVGIVNEQELKQIVGA

Core:

GDITPQTTDALSAVIVSVLPTLKCSSQCRTDL

Core with dehydrations:

GDIDhbPQDhbDhbDALDhaAVIVDhaVLPDhbLKCysDhaDhaQCysRDhbDL

antiSMASH-DB 4.0 matches for WR47_RS28825

100.0%

NZ_CP011152.1and 1 other:

NZ_CP011152.1 Lanthipeptides: WR47_RS28825_lanthipeptide

Lanthipeptides: WR47_RS28825_lanthipeptide

1

GDITPQTTDALSAVIVSVLPTLKCSSQCRTDL

32

GDITPQTTDALSAVIVSVLPTLKCSSQCRTDL

1

GDITPQTTDALSAVIVSVLPTLKCSSQCRTDL

32

60.0%

NZ_CP011152.1and 3 others:

NZ_CP011152.1 Lanthipeptides: WR47_RS28830_lanthipeptideNZ_CP011152.1 Lanthipeptides: WR47_RS28835_lanthipeptideNZ_CP011152.1 Lanthipeptides: WR47_RS28830_lanthipeptide

Lanthipeptides: WR47_RS28835_lanthipeptide

1

GDITPQTTD--------ALSAVIVSVLPTLKCSSQCRTDL

32

GD+TPQ T A AVI +VLPTLKCSS+CRTDL

1

GDVTPQATPTVTILATAAGGAVISAVLPTLKCSSKCRTDL

40

46.9%

NZ_CP013862.1and 1 other:

NZ_CP013862.1 Lanthipeptides: AOX59_RS09365_lanthipeptide

Lanthipeptides: AOX59_RS09365_lanthipeptide

1

GDITPQTTDALSAVIVSV----LPTLKCSSQC

28

GD+ PQTT + A ++V PT KC+SQC

1

GDVDPQTTPSSVACGIAVSALFCPTTKCTSQC

32

with 88 more sequence matches

Only the first 10 are displayed here.

43.8%

NC_018499.1and 5 others:

NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27845_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide

Lanthipeptides: BCK_RS27845_lanthipeptide

1

GDITPQTTDA---LSAVIVSVLPTLKCSSQC

28

GD+ P+TT A + AV + + PT KC+S+C

1

GDVNPETTPATPTIVAVSLGICPTTKCTSKC

31

42.9%

NZ_CM000721.1and 9 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

1

GDITPQTTDALS-------AVIVSVLPTLKCSSQC

28

GD+ P+TT A AV S+ PT KC+S+C

1

GDVNPETTPATPTIIGATIAVTASLCPTTKCTSRC

35

40.6%

NZ_CP036019.1and 1 other:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27205_lanthipeptide

Lanthipeptides: EXW52_RS27205_lanthipeptide

1

GDITPQTTDALSAVIVSV----LPTLKCSSQC

28

GD++P+TT A ++V++ PT KC+S+C

1

GDVSPETTPATPTIVVAISVGLCPTTKCTSKC

32

40.6%

NZ_MLKL01000042.1:

Lanthipeptides: BKK45_RS27405_lanthipeptide

1

GDITPQTTDA---LSAVIVSVLPTLKCSSQC

28

GD+ P+TT A + AV V + PT C+ C

1

GDVNPETTPATPTIVAVSVKLCPTGVCTKSC

31

40.6%

Lanthipeptides: COD66_RS20140_lanthipeptide

1

GDITPQTTDALSAVIVSV----LPTLKCSSQC

28

GD++P+TT A ++V + PT KC+S+C

1

GDVSPETTPATPTIVVGISVGLCPTTKCTSKC

32

40.0%

NZ_CP015591.1and 15 others:

NZ_CP078085.1 Lanthipeptides: KU891_RS29355_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29350_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29345_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29340_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29335_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptide

Lanthipeptides: A7A70_RS27550_lanthipeptide

1

GDITPQTTDALSAVI-------VSVLPTLKCSSQC

28

GD+ P+TT A ++ VS+ PT KC+S+C

1

GDVNPETTPATPTIVEATIAATVSICPTTKCTSRC

35

38.5%

NZ_CP009288.1and 3 others:

NZ_CP009288.1 Lanthipeptides: PDUR_RS29295_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptide

Lanthipeptides: PDUR_RS29295_lanthipeptide

1

GDITPQTT----------DALSAVIVSVLPTLKCSSQC

28

GD+ P+TT A V S+ PT KC+SQC

2

GDVNPETTILTTSSWTCITAGVTVSASLCPTTKCTSQC

39

37.5%

NZ_CP036019.1and 7 others:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27180_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27175_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27170_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27190_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27180_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27175_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27170_lanthipeptide

Lanthipeptides: EXW52_RS27190_lanthipeptide

1

GDITPQTTDALSAVIVSV----LPTLKCSSQC

28

GD++P+TT A ++V++ PT +C+S+C

1

GDVSPETTPATPTIVVAISVGLCPTNRCTSKC

32

37.5%

NZ_JACSMH010000008.1and 2 others:

NZ_JACSMX010000006.1 Lanthipeptides: KNQ03_RS15615_lanthipeptideNZ_JACSMZ010000005.1 Lanthipeptides: KNQ06_RS16025_lanthipeptide

Lanthipeptides: KNP89_RS14470_lanthipeptide

1

GDITPQTTDALSAVIVSVLPTLKCSSQCR

29

GD+ P+TT VIV V +L S+C+

1

GDVQPETTPFCVGVIVGVTISL---SKCK

26

37.5%

NZ_JAQQWR010000009.1:

Lanthipeptides: PQ473_RS20130_lanthipeptide

1

GDITPQTTDA-LSAVIVSVLPTLKCSSQCR

29

GD+ P+TT A VI +V L ++CR

1

GDVNPETTPACFYGVIGTV--GLFSVAKCR

28

MIBiG 4.0 matches for WR47_RS28825

18.8%

Lanthipeptide: birimositide

18

VLPTLKCSSQC

28

PT KC+S+C

16

FCPTTKCTSKC

26

16.2%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

20

PTLKCSSQC

28

PT KC+S+C

29

PTTKCTSRC

37

WR47_RS28830

Leader:

MSKNEVKALRNPKMRTEDFNNPVGIVNEQELRQIVGA

WR47_RS28835

Leader:

MSKNEVKALRNPKMRTEDFNNPVGIVNEQELRQIVGA

Shared core:

GDVTPQATPTVTILATAAGGAVISAVLPTLKCSSKCRTDL

Core with dehydrations:

GDVDhbPQADhbPDhbVDhbILADhbAAGGAVIDhaAVLPDhbLKCysDhaDhaKCysRDhbDL

antiSMASH-DB 4.0 matches for WR47_RS28830

100.0%

NZ_CP011152.1and 3 others:

NZ_CP011152.1 Lanthipeptides: WR47_RS28830_lanthipeptideNZ_CP011152.1 Lanthipeptides: WR47_RS28835_lanthipeptideNZ_CP011152.1 Lanthipeptides: WR47_RS28830_lanthipeptide

Lanthipeptides: WR47_RS28835_lanthipeptide

1

GDVTPQATPTVTILATAAGGAVISAVLPTLKCSSKCRTDL

40

GDVTPQATPTVTILATAAGGAVISAVLPTLKCSSKCRTDL

1

GDVTPQATPTVTILATAAGGAVISAVLPTLKCSSKCRTDL

40

60.0%

NZ_CP011152.1and 1 other:

NZ_CP011152.1 Lanthipeptides: WR47_RS28825_lanthipeptide

Lanthipeptides: WR47_RS28825_lanthipeptide

1

GDVTPQATPTVTILATAAGGAVISAVLPTLKCSSKCRTDL

40

GD+TPQ T A AVI +VLPTLKCSS+CRTDL

1

GDITPQTTD--------ALSAVIVSVLPTLKCSSQCRTDL

32

52.5%

NZ_CP009280.1and 1 other:

NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide

Lanthipeptides: P40081_RS37160_lanthipeptide

1

GDVTPQATPTVTILATAAGGAV-ISAVL-PTLKCSSKC

36

GDV P+ TP T GAV ISA L PT KC+SKC

2

GDVNPETTPLTTSSWPCVIGAVDISANLCPTTKCTSKC

39

with 114 more sequence matches

Only the first 10 are displayed here.

47.5%

NZ_CP085411.1and 1 other:

NZ_CP085411.1 Lanthipeptides: LIT28_RS29915_lanthipeptide

Lanthipeptides: LIT28_RS29915_lanthipeptide

1

GDVTPQATPTVTILATAAGGAVISAVLPTLKCSSKC

36

GDV P+ TPT + T GA IS V PT KC+S+C

1

GDVNPETTPTTATVTTVLVGATIS-VCPTTKCTSRC

35

45.0%

NC_018499.1and 5 others:

NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27845_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide

Lanthipeptides: BCK_RS27845_lanthipeptide

1

GDVTPQATP-TVTILATAAGGAVISAVLPTLKCSSKC

36

GDV P+ TP T TI+A + G + PT KC+SKC

1

GDVNPETTPATPTIVAVSLG------ICPTTKCTSKC

31

45.0%

NZ_CM000721.1and 9 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

1

GDVTPQATP-TVTILATAAGGAVISAVLPTLKCSSKC

36

GDV P+ TP T TI+ A AV +++ PT KC+S+C

1

GDVNPETTPATPTIIG--ATIAVTASLCPTTKCTSRC

35

45.0%

NZ_QNUC01000031.1and 1 other:

NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23045_lanthipeptide

Lanthipeptides: DN396_RS23045_lanthipeptide

1

GDVTPQATPTVTILATAAGGAVISAVLPTLKCSSKC

36

GDV P+ TPT + T GA IS + PT KC+S+C

1

GDVNPETTPTTATVTTVLVGATIS-ICPTTKCTSRC

35

42.5%

NZ_CP013862.1and 1 other:

NZ_CP013862.1 Lanthipeptides: AOX59_RS09365_lanthipeptide

Lanthipeptides: AOX59_RS09365_lanthipeptide

1

GDVTPQATPTVTILATAAGGAVISAVLPTLKCSSKC

36

GDV PQ TP+ + A G AV + PT KC+S+C

1

GDVDPQTTPS----SVACGIAVSALFCPTTKCTSQC

32

42.5%

NZ_CP036019.1and 1 other:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27205_lanthipeptide

Lanthipeptides: EXW52_RS27205_lanthipeptide

1

GDVTPQATP-TVTILATAAGGAVISAVLPTLKCSSKC

36

GDV+P+ TP T TI+ A+ + PT KC+SKC

1

GDVSPETTPATPTIVV-----AISVGLCPTTKCTSKC

32

42.5%

NZ_JAQDYA010000001.1:

Lanthipeptides: PGT72_RS00025_lanthipeptide

1

GDVTPQATP----TVTILATAAGG--AVISAVLPTLKC

32

GD+TP+ TP TV A AG AV VL KC

1

GDITPETTPVCAATVASSAYCAGAASAVSGIVLSVFKC

38

42.5%

Lanthipeptides: COD66_RS20140_lanthipeptide

1

GDVTPQATP-TVTILATAAGGAVISAVLPTLKCSSKC

36

GDV+P+ TP T TI+ + G + PT KC+SKC

1

GDVSPETTPATPTIVVGISVG-----LCPTTKCTSKC

32

42.5%

NZ_NVJC01000007.1:

Lanthipeptides: COM38_RS07270_lanthipeptide

1

GDVTPQATPTVTILATAAGGAVISAVLPTLKC

32

GDV P+ TPT + T GA IS V PT KC

1

GDVNPETTPTTATVTTVLVGATIS-VCPTTKC

31

40.0%

NC_006322.1and 7 others:

NC_006322.1 Lanthipeptides: BLI_RS20290_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptide

Lanthipeptides: BLI_RS20290_lanthipeptide

1

GDVTPQATPTVTILATA--AGGAVISAVLPTLKCSSKC

36

DV P+ TP T T AG V +++ PT KC+S+C

1

NDVNPETTPATTSSWTCITAGVTVSASLCPTTKCTSRC

38

MIBiG 4.0 matches for WR47_RS28830

32.5%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

13

ILATAAGGAV--ISAVLPTLKCSSKC

36

I+A AG AV +A PT KC+S+C

12

IVAIQAGVAVGVSAAFCPTTKCTSRC

37

17.5%

BGC0000553.3 (SSGG_RS09925):

Lanthipeptide: birimositide

26

VLPTLKCSSKC

36

PT KC+SKC

16

FCPTTKCTSKC

26

allorf_279614_279820

Leader:

MVSSSSPLILNVSFGF

Core:

VITQTTISSLMTVVALSNTKSIKSIYIILMILFPRIPSFSFKISLSLCQPCP

Core with dehydrations:

VIDhbQDhbDhbIDhaDhaLMDhbVVALDhaNDhbKDhaIKDhaIYIILMILFPRIPDhaFDhaFKIDhaLDhaLCysQPCysP

antiSMASH-DB 4.0 matches for allorf_279614_279820

15.4%

NZ_QKUF01000008.1:

Lanthipeptides: allorf_238869_239036_lanthipeptide

24

SIYIILMILF

33

SIYIILM+L+

13

SIYIILMVLY

22

MIBiG 4.0 matches for allorf_279614_279820

5.8%

Lanthipeptide: SRO15-2212

42

KISLSLCQ

49

++SL +C+

4

QVSLLVCE

11

allorf_280153_280365

Leader:

MGVMDKRKDTLRCPPPTYKSNLYFIHFIQYG

Core:

DDGLCIALEPNHAISISGHHDIQNQSFIVFRQKTPSSKM

Core with dehydrations:

DDGLCysIALEPNHAIDhaIDhaGHHDIQNQDhaFIVFRQKDhbPDhaDhaKM

allorf_299763_299852

Leader:

MFKKEYFRIYIIAAVLGS

Core:

LLTCFYYYYYK

Core with dehydrations:

LLDhbCysFYYYYYK

antiSMASH-DB 4.0 matches for allorf_299763_299852

100.0%

NZ_CP011152.1:

Lanthipeptides: allorf_299763_299852_lanthipeptide

1

LLTCFYYYYYK

11

LLTCFYYYYYK

1

LLTCFYYYYYK

11

Lanthipeptide(s) for WR47_RS28840

WR47_RS28810

Leader:

MKNNSIMRFWKDPLYRMDLSSDERGNMPGS

Core:

PVGDSLEEIQGNELLNAVGAGDVQANTSTVQILTPRTPIISNTLGNKGHACTITKECQNMCN

Core with dehydrations:

PVGDDhaLEEIQGNELLNAVGAGDVQANDhbDhaDhbVQILDhbPRDhbPIIDhaNDhbLGNKGHACysDhbIDhbKECysQNMCysN

antiSMASH-DB 4.0 matches for WR47_RS28810

100.0%

NZ_CP011152.1and 1 other:

NZ_CP011152.1 Lanthipeptides: WR47_RS28810_lanthipeptide

Lanthipeptides: WR47_RS28810_lanthipeptide

1

PVGDSLEEIQGNELLNAVGAGDVQANTSTVQILTPRTPIISNTLGNKGHACTITKECQNMCN

62

PVGDSLEEIQGNELLNAVGAGDVQANTSTVQILTPRTPIISNTLGNKGHACTITKECQNMCN

1

PVGDSLEEIQGNELLNAVGAGDVQANTSTVQILTPRTPIISNTLGNKGHACTITKECQNMCN

62

84.4%

NZ_CP011152.1and 3 others:

NZ_CP011152.1 Lanthipeptides: WR47_RS28815_lanthipeptideNZ_CP011152.1 Lanthipeptides: WR47_RS28820_lanthipeptideNZ_CP011152.1 Lanthipeptides: WR47_RS28815_lanthipeptide

Lanthipeptides: WR47_RS28820_lanthipeptide

1

PVGDSLEEIQGNELLNAVGAGDVQANTSTVQI--LTPRTPIISNTLGNKGHACTITKECQNMCN

62

PVGDSLEEIQGNELLNAVGAGDVQANT+T+ + LT ++P ISNTLGNKGHACTITKECQNMCN

1

PVGDSLEEIQGNELLNAVGAGDVQANTNTIVVTQLTAKSPYISNTLGNKGHACTITKECQNMCN

64

30.6%

NZ_CP009288.1and 3 others:

NZ_CP009288.1 Lanthipeptides: PDUR_RS25150_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptide

Lanthipeptides: PDUR_RS25150_lanthipeptide

33

LTPRTPI-ISNTLGNKGHACTITKECQNMCN

62

LT T I IS TLGN G CT TKEC CN

6

LTTSTSILISMTLGNNGWVCTATKECMPSCN

36

with 112 more sequence matches

Only the first 10 are displayed here.

29.0%

NZ_JALGRP010000007.1and 1 other:

NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide

Lanthipeptides: MT347_RS12955_lanthipeptide

24

QANTSTVQILTPRTPIISNTLGNKGHACTITKECQNMCN

62

Q T+T+ LT +S GN G CT T ECQN CN

3

QGWTTTITSLTCYG--VSWVAGNNGQVCTATVECQNNCN

39

27.4%

NZ_BMFU01000012.1and 5 others:

NZ_BMFU01000012.1 Lanthipeptides: IEW26_RS25375_lanthipeptideNZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23855_lanthipeptideNZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23855_lanthipeptideNZ_VDYW01000008.1 Lanthipeptides: FS579_RS24445_lanthipeptideNZ_VDYW01000008.1 Lanthipeptides: FS579_RS24445_lanthipeptide

Lanthipeptides: IEW26_RS25375_lanthipeptide

21

GDVQANTSTVQILTPRTPIISNTLGNKGHACTITKECQNMCN

62

G Q V I + S +GN GH CT+T ECQ CN

1

GAAQPEWVEVIITSLACAAASYFMGNPGHVCTLTVECQKSCN

42

27.4%

NZ_CP009280.1and 1 other:

NZ_CP009280.1 Lanthipeptides: P40081_RS01820_lanthipeptide

Lanthipeptides: P40081_RS01820_lanthipeptide

33

LTPRTPI-ISNTLGNKGHACTITKECQNMCN

62

LT T I IS LGN G CT +KEC CN

6

LTTSTSIFISRGLGNDGWVCTWSKECMPSCN

36

27.4%

NZ_CP084530.1and 1 other:

NZ_CP084530.1 Lanthipeptides: LDO05_RS02075_lanthipeptide

Lanthipeptides: LDO05_RS02075_lanthipeptide

34

TPRTPIISNTLGNKGHACTITKECQNMCN

62

T T +SN LGN G CT+TKECQ CN

2

TTNTFTLSNYLGNNGGWCTLTKECQRSCN

30

27.4%

NZ_JACHKG010000014.1and 1 other:

NZ_JACHKG010000014.1 Lanthipeptides: allorf_027480_027638_lanthipeptide

Lanthipeptides: allorf_027480_027638_lanthipeptide

21

GDVQANTSTVQILTPRTPIISNTLGNKGHACTITKECQNMCN

62

G Q + V I + S +GN GH CT+T ECQ CN

1

GAAQPQWAEVIITSLACAAASYFMGNPGHVCTLTVECQKSCN

42

27.4%

NZ_LT985747.1and 1 other:

NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide

Lanthipeptides: C8268_RS00165_lanthipeptide

34

TPRTPIISNTLGNKGHACTITKECQNMCN

62

T T +S+ LGNKG CT+TKECQ CN

2

TTNTFTLSDYLGNKGGWCTLTKECQRSCN

30

25.8%

NZ_BJTV01000004.1and 1 other:

NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS10200_lanthipeptide

Lanthipeptides: TNCT1_RS10200_lanthipeptide

34

TPRTPIISNTLGNKGHACTITKECQNMCN

62

T T +S+ LGN G CT+TKECQ CN

2

TTNTFSLSDALGNHGGWCTLTKECQANCN

30

25.8%

NZ_BNBV01000031.1and 1 other:

NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22995_lanthipeptide

Lanthipeptides: IE286_RS22995_lanthipeptide

34

TPRTPIISNTLGNKGHACTITKECQNMCN

62

T T +S+ LGN G CT+TKECQ CN

2

TTNTFSLSDALGNSGGWCTLTKECQPNCN

30

25.8%

NZ_CM000756.1and 7 others:

NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS34475_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide

Lanthipeptides: BTHUR0011_RS34475_lanthipeptide

34

TPRTPIISNTLGNKGHACTITKECQNMC

61

T + IIS T GNKG CT T EC N C

9

TSTSIIISETFGNKGKVCTYTVECVNNC

36

25.8%

NZ_CP025249.1and 1 other:

NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide

Lanthipeptides: CWT12_RS00385_lanthipeptide

38

PIISNTLGNKGHACTITKECQNMCN

62

P +S LGN G+ CT+TKECQ MCN

3

PWLSRKLGNTGYVCTLTKECQRMCN

27

MIBiG 4.0 matches for WR47_RS28810

27.4%

Lanthipeptide: birimositide

34

TPRTPIISNTLGNKGHACTITKECQNMCN

62

T T +SN LGN G CT+TKECQ CN

2

TTNTFSLSNALGNNGGWCTLTKECQPNCN

30

22.6%

Lanthipeptide: haloduracin β or haloduracin α

40

ISNTLGNKGHACTITKECQNMCN

62

IS LGNKG CT+T EC CN

6

ISCRLGNKGAYCTLTVECMPSCN

28

12.9%

BGC0000582.4 (ADR72962.1):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

51

CTITKECQNMCN

62

CT++KECQ CN

28

CTLSKECQPNCN

39

with 1 more sequence matches

8.1%

Linaridin: cypemycin

34

TPRTPIISNTLGNKGHACTI

53

TP TP ++ + C +

2

TPATPTVAQFVIQGSTICLV

21

WR47_RS28815

Leader:

MKNNSIMRFWKDPLYRMDLSSDERGNMPGS

WR47_RS28820

Leader:

MKNNSIMRFWKDPLYRMDLSSDERGNMPGS

Shared core:

PVGDSLEEIQGNELLNAVGAGDVQANTNTIVVTQLTAKSPYISNTLGNKGHACTITKECQNMCN

Core with dehydrations:

PVGDDhaLEEIQGNELLNAVGAGDVQANDhbNDhbIVVDhbQLDhbAKDhaPYIDhaNDhbLGNKGHACysDhbIDhbKECysQNMCysN

antiSMASH-DB 4.0 matches for WR47_RS28815

100.0%

NZ_CP011152.1and 3 others:

NZ_CP011152.1 Lanthipeptides: WR47_RS28815_lanthipeptideNZ_CP011152.1 Lanthipeptides: WR47_RS28820_lanthipeptideNZ_CP011152.1 Lanthipeptides: WR47_RS28815_lanthipeptide

Lanthipeptides: WR47_RS28820_lanthipeptide

1

PVGDSLEEIQGNELLNAVGAGDVQANTNTIVVTQLTAKSPYISNTLGNKGHACTITKECQNMCN

64

PVGDSLEEIQGNELLNAVGAGDVQANTNTIVVTQLTAKSPYISNTLGNKGHACTITKECQNMCN

1

PVGDSLEEIQGNELLNAVGAGDVQANTNTIVVTQLTAKSPYISNTLGNKGHACTITKECQNMCN

64

84.4%

NZ_CP011152.1and 1 other:

NZ_CP011152.1 Lanthipeptides: WR47_RS28810_lanthipeptide

Lanthipeptides: WR47_RS28810_lanthipeptide

1

PVGDSLEEIQGNELLNAVGAGDVQANTNTIVVTQLTAKSPYISNTLGNKGHACTITKECQNMCN

64

PVGDSLEEIQGNELLNAVGAGDVQANT+T+ + LT ++P ISNTLGNKGHACTITKECQNMCN

1

PVGDSLEEIQGNELLNAVGAGDVQANTSTVQI--LTPRTPIISNTLGNKGHACTITKECQNMCN

62

28.1%

NZ_CP009280.1and 1 other:

NZ_CP009280.1 Lanthipeptides: P40081_RS01820_lanthipeptide

Lanthipeptides: P40081_RS01820_lanthipeptide

26

NTNTIVVTQLTAKSPYISNTLGNKGHACTITKECQNMCN

64

+TNT+ T+ S +IS LGN G CT +KEC CN

2

DTNTLT----TSTSIFISRGLGNDGWVCTWSKECMPSCN

36

with 111 more sequence matches

Only the first 10 are displayed here.

28.1%

NZ_CP009288.1and 3 others:

NZ_CP009288.1 Lanthipeptides: PDUR_RS25150_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptide

Lanthipeptides: PDUR_RS25150_lanthipeptide

33

TQLTAKSPYISNTLGNKGHACTITKECQNMCN

64

T T+ S IS TLGN G CT TKEC CN

5

TLTTSTSILISMTLGNNGWVCTATKECMPSCN

36

28.1%

NZ_JALIRS010000003.1and 3 others:

NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07255_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide

Lanthipeptides: MOK21_RS07255_lanthipeptide

29

TIVVTQLTAKSPYISNTLGNKGHACTITKECQNMCN

64

TI+ + A + YI LGN GH CT+T ECQ CN

8

TILTSLACAAASYI---LGNPGHVCTLTVECQKKCN

40

26.6%

NZ_BMFU01000012.1and 5 others:

NZ_BMFU01000012.1 Lanthipeptides: IEW26_RS25375_lanthipeptideNZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23855_lanthipeptideNZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23855_lanthipeptideNZ_VDYW01000008.1 Lanthipeptides: FS579_RS24445_lanthipeptideNZ_VDYW01000008.1 Lanthipeptides: FS579_RS24445_lanthipeptide

Lanthipeptides: IEW26_RS25375_lanthipeptide

21

GDVQANTNTIVVTQLTAKSPYISNTLGNKGHACTITKECQNMCN

64

G Q +++T L + S +GN GH CT+T ECQ CN

1

GAAQPEWVEVIITSLACAAA--SYFMGNPGHVCTLTVECQKSCN

42

26.6%

NZ_CM000756.1and 7 others:

NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS34475_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide

Lanthipeptides: BTHUR0011_RS34475_lanthipeptide

33

TQLTAKSPYISNTLGNKGHACTITKECQNMC

63

T T+ S IS T GNKG CT T EC N C

6

TTATSTSIIISETFGNKGKVCTYTVECVNNC

36

26.6%

NZ_CP017953.1and 27 others:

NZ_CP017953.1 Lanthipeptides: BAMY_RS16400_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptideNZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptideNZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptideNZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptideNZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptideNZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptideNZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptideNZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptideNZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptideNZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptideNZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptideNZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptideNZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptide

Lanthipeptides: BAMY_RS16400_lanthipeptide

28

NTIVVTQLTAKSPYISNTLGNKGHACTITKECQNMC

63

NT T + +S LGNKG CT TKECQ C

2

NTWNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

26.6%

NZ_JACHKG010000014.1and 1 other:

NZ_JACHKG010000014.1 Lanthipeptides: allorf_027480_027638_lanthipeptide

Lanthipeptides: allorf_027480_027638_lanthipeptide

21

GDVQANTNTIVVTQLTAKSPYISNTLGNKGHACTITKECQNMCN

64

G Q +++T L + S +GN GH CT+T ECQ CN

1

GAAQPQWAEVIITSLACAAA--SYFMGNPGHVCTLTVECQKSCN

42

26.6%

NZ_JALGRP010000007.1and 1 other:

NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide

Lanthipeptides: MT347_RS12955_lanthipeptide

29

TIVVTQLTAKSPYISNTLGNKGHACTITKECQNMCN

64

T +T LT +S GN G CT T ECQN CN

6

TTTITSLTCYG--VSWVAGNNGQVCTATVECQNNCN

39

25.0%

NZ_BMRY01000003.1and 24 others:

NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide

Lanthipeptides: IE140_RS12370_lanthipeptide

29

TIVVTQLTAKSPYISNTLGNKGHACTITKECQNMC

63

TIV + + Y+ LGN G+ CT T ECQN C

6

TIVSSLSCYGASYV---LGNNGNFCTATAECQNNC

37

25.0%

NZ_CKMQ01000043.1and 10 others:

NZ_CKMQ01000043.1 Lanthipeptides: AE832_RS11585_lanthipeptideNZ_CKMR01000002.1 Lanthipeptides: AD782_RS11690_lanthipeptideNZ_CKMR01000002.1 Lanthipeptides: AD782_RS11690_lanthipeptideNZ_FIXU01000003.1 Lanthipeptides: A1M11_RS11670_lanthipeptideNZ_FIXU01000003.1 Lanthipeptides: A1M11_RS11670_lanthipeptideNZ_LR216041.1 Lanthipeptides: E0F00_RS05465_lanthipeptideNZ_LR216046.1 Lanthipeptides: E0E82_RS05980_lanthipeptideNZ_LR216046.1 Lanthipeptides: E0E82_RS05980_lanthipeptideNZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00170_lanthipeptideNZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00170_lanthipeptide

Lanthipeptides: AE832_RS11585_lanthipeptide

37

AKSPYISNTLGNKGHACTITKECQNMCN

64

A+ +IS LGNKG CT T ECQN C

3

AQLSFISEALGNKGAVCTGTIECQNNCR

30

25.0%

NZ_CP025249.1and 1 other:

NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide

Lanthipeptides: CWT12_RS00385_lanthipeptide

40

PYISNTLGNKGHACTITKECQNMCN

64

P++S LGN G+ CT+TKECQ MCN

3

PWLSRKLGNTGYVCTLTKECQRMCN

27

MIBiG 4.0 matches for WR47_RS28815

23.4%

Lanthipeptide: birimositide

42

ISNTLGNKGHACTITKECQNMCN

64

+SN LGN G CT+TKECQ CN

8

LSNALGNNGGWCTLTKECQPNCN

30

21.9%

Lanthipeptide: haloduracin β or haloduracin α

42

ISNTLGNKGHACTITKECQNMCN

64

IS LGNKG CT+T EC CN

6

ISCRLGNKGAYCTLTVECMPSCN

28

12.5%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

53

CTITKECQNMCN

64

CT++KECQ CN

28

CTLSKECQPNCN

39

WR47_RS28825

Leader:

MSKNEVKSLRDPKMRTEDFNNPVGIVNEQELKQIVGA

Core:

GDITPQTTDALSAVIVSVLPTLKCSSQCRTDL

Core with dehydrations:

GDIDhbPQDhbDhbDALDhaAVIVDhaVLPDhbLKCysDhaDhaQCysRDhbDL

antiSMASH-DB 4.0 matches for WR47_RS28825

100.0%

NZ_CP011152.1and 1 other:

NZ_CP011152.1 Lanthipeptides: WR47_RS28825_lanthipeptide

Lanthipeptides: WR47_RS28825_lanthipeptide

1

GDITPQTTDALSAVIVSVLPTLKCSSQCRTDL

32

GDITPQTTDALSAVIVSVLPTLKCSSQCRTDL

1

GDITPQTTDALSAVIVSVLPTLKCSSQCRTDL

32

60.0%

NZ_CP011152.1and 3 others:

NZ_CP011152.1 Lanthipeptides: WR47_RS28830_lanthipeptideNZ_CP011152.1 Lanthipeptides: WR47_RS28835_lanthipeptideNZ_CP011152.1 Lanthipeptides: WR47_RS28830_lanthipeptide

Lanthipeptides: WR47_RS28835_lanthipeptide

1

GDITPQTTD--------ALSAVIVSVLPTLKCSSQCRTDL

32

GD+TPQ T A AVI +VLPTLKCSS+CRTDL

1

GDVTPQATPTVTILATAAGGAVISAVLPTLKCSSKCRTDL

40

46.9%

NZ_CP013862.1and 1 other:

NZ_CP013862.1 Lanthipeptides: AOX59_RS09365_lanthipeptide

Lanthipeptides: AOX59_RS09365_lanthipeptide

1

GDITPQTTDALSAVIVSV----LPTLKCSSQC

28

GD+ PQTT + A ++V PT KC+SQC

1

GDVDPQTTPSSVACGIAVSALFCPTTKCTSQC

32

with 88 more sequence matches

Only the first 10 are displayed here.

43.8%

NC_018499.1and 5 others:

NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27845_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide

Lanthipeptides: BCK_RS27845_lanthipeptide

1

GDITPQTTDA---LSAVIVSVLPTLKCSSQC

28

GD+ P+TT A + AV + + PT KC+S+C

1

GDVNPETTPATPTIVAVSLGICPTTKCTSKC

31

42.9%

NZ_CM000721.1and 9 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

1

GDITPQTTDALS-------AVIVSVLPTLKCSSQC

28

GD+ P+TT A AV S+ PT KC+S+C

1

GDVNPETTPATPTIIGATIAVTASLCPTTKCTSRC

35

40.6%

NZ_CP036019.1and 1 other:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27205_lanthipeptide

Lanthipeptides: EXW52_RS27205_lanthipeptide

1

GDITPQTTDALSAVIVSV----LPTLKCSSQC

28

GD++P+TT A ++V++ PT KC+S+C

1

GDVSPETTPATPTIVVAISVGLCPTTKCTSKC

32

40.6%

NZ_MLKL01000042.1:

Lanthipeptides: BKK45_RS27405_lanthipeptide

1

GDITPQTTDA---LSAVIVSVLPTLKCSSQC

28

GD+ P+TT A + AV V + PT C+ C

1

GDVNPETTPATPTIVAVSVKLCPTGVCTKSC

31

40.6%

Lanthipeptides: COD66_RS20140_lanthipeptide

1

GDITPQTTDALSAVIVSV----LPTLKCSSQC

28

GD++P+TT A ++V + PT KC+S+C

1

GDVSPETTPATPTIVVGISVGLCPTTKCTSKC

32

40.0%

NZ_CP015591.1and 15 others:

NZ_CP078085.1 Lanthipeptides: KU891_RS29355_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29350_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29345_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29340_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29335_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptide

Lanthipeptides: A7A70_RS27550_lanthipeptide

1

GDITPQTTDALSAVI-------VSVLPTLKCSSQC

28

GD+ P+TT A ++ VS+ PT KC+S+C

1

GDVNPETTPATPTIVEATIAATVSICPTTKCTSRC

35

38.5%

NZ_CP009288.1and 3 others:

NZ_CP009288.1 Lanthipeptides: PDUR_RS29295_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptide

Lanthipeptides: PDUR_RS29295_lanthipeptide

1

GDITPQTT----------DALSAVIVSVLPTLKCSSQC

28

GD+ P+TT A V S+ PT KC+SQC

2

GDVNPETTILTTSSWTCITAGVTVSASLCPTTKCTSQC

39

37.5%

NZ_CP036019.1and 7 others:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27180_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27175_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27170_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27190_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27180_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27175_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27170_lanthipeptide

Lanthipeptides: EXW52_RS27190_lanthipeptide

1

GDITPQTTDALSAVIVSV----LPTLKCSSQC

28

GD++P+TT A ++V++ PT +C+S+C

1

GDVSPETTPATPTIVVAISVGLCPTNRCTSKC

32

37.5%

NZ_JACSMH010000008.1and 2 others:

NZ_JACSMX010000006.1 Lanthipeptides: KNQ03_RS15615_lanthipeptideNZ_JACSMZ010000005.1 Lanthipeptides: KNQ06_RS16025_lanthipeptide

Lanthipeptides: KNP89_RS14470_lanthipeptide

1

GDITPQTTDALSAVIVSVLPTLKCSSQCR

29

GD+ P+TT VIV V +L S+C+

1

GDVQPETTPFCVGVIVGVTISL---SKCK

26

37.5%

NZ_JAQQWR010000009.1:

Lanthipeptides: PQ473_RS20130_lanthipeptide

1

GDITPQTTDA-LSAVIVSVLPTLKCSSQCR

29

GD+ P+TT A VI +V L ++CR

1

GDVNPETTPACFYGVIGTV--GLFSVAKCR

28

MIBiG 4.0 matches for WR47_RS28825

18.8%

Lanthipeptide: birimositide

18

VLPTLKCSSQC

28

PT KC+S+C

16

FCPTTKCTSKC

26

16.2%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

20

PTLKCSSQC

28

PT KC+S+C

29

PTTKCTSRC

37

WR47_RS28830

Leader:

MSKNEVKALRNPKMRTEDFNNPVGIVNEQELRQIVGA

WR47_RS28835

Leader:

MSKNEVKALRNPKMRTEDFNNPVGIVNEQELRQIVGA

Shared core:

GDVTPQATPTVTILATAAGGAVISAVLPTLKCSSKCRTDL

Core with dehydrations:

GDVDhbPQADhbPDhbVDhbILADhbAAGGAVIDhaAVLPDhbLKCysDhaDhaKCysRDhbDL

antiSMASH-DB 4.0 matches for WR47_RS28830

100.0%

NZ_CP011152.1and 3 others:

NZ_CP011152.1 Lanthipeptides: WR47_RS28830_lanthipeptideNZ_CP011152.1 Lanthipeptides: WR47_RS28835_lanthipeptideNZ_CP011152.1 Lanthipeptides: WR47_RS28830_lanthipeptide

Lanthipeptides: WR47_RS28835_lanthipeptide

1

GDVTPQATPTVTILATAAGGAVISAVLPTLKCSSKCRTDL

40

GDVTPQATPTVTILATAAGGAVISAVLPTLKCSSKCRTDL

1

GDVTPQATPTVTILATAAGGAVISAVLPTLKCSSKCRTDL

40

60.0%

NZ_CP011152.1and 1 other:

NZ_CP011152.1 Lanthipeptides: WR47_RS28825_lanthipeptide

Lanthipeptides: WR47_RS28825_lanthipeptide

1

GDVTPQATPTVTILATAAGGAVISAVLPTLKCSSKCRTDL

40

GD+TPQ T A AVI +VLPTLKCSS+CRTDL

1

GDITPQTTD--------ALSAVIVSVLPTLKCSSQCRTDL

32

52.5%

NZ_CP009280.1and 1 other:

NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide

Lanthipeptides: P40081_RS37160_lanthipeptide

1

GDVTPQATPTVTILATAAGGAV-ISAVL-PTLKCSSKC

36

GDV P+ TP T GAV ISA L PT KC+SKC

2

GDVNPETTPLTTSSWPCVIGAVDISANLCPTTKCTSKC

39

with 114 more sequence matches

Only the first 10 are displayed here.

47.5%

NZ_CP085411.1and 1 other:

NZ_CP085411.1 Lanthipeptides: LIT28_RS29915_lanthipeptide

Lanthipeptides: LIT28_RS29915_lanthipeptide

1

GDVTPQATPTVTILATAAGGAVISAVLPTLKCSSKC

36

GDV P+ TPT + T GA IS V PT KC+S+C

1

GDVNPETTPTTATVTTVLVGATIS-VCPTTKCTSRC

35

45.0%

NC_018499.1and 5 others:

NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27845_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide

Lanthipeptides: BCK_RS27845_lanthipeptide

1

GDVTPQATP-TVTILATAAGGAVISAVLPTLKCSSKC

36

GDV P+ TP T TI+A + G + PT KC+SKC

1

GDVNPETTPATPTIVAVSLG------ICPTTKCTSKC

31

45.0%

NZ_CM000721.1and 9 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

1

GDVTPQATP-TVTILATAAGGAVISAVLPTLKCSSKC

36

GDV P+ TP T TI+ A AV +++ PT KC+S+C

1

GDVNPETTPATPTIIG--ATIAVTASLCPTTKCTSRC

35

45.0%

NZ_QNUC01000031.1and 1 other:

NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23045_lanthipeptide

Lanthipeptides: DN396_RS23045_lanthipeptide

1

GDVTPQATPTVTILATAAGGAVISAVLPTLKCSSKC

36

GDV P+ TPT + T GA IS + PT KC+S+C

1

GDVNPETTPTTATVTTVLVGATIS-ICPTTKCTSRC

35

42.5%

NZ_CP013862.1and 1 other:

NZ_CP013862.1 Lanthipeptides: AOX59_RS09365_lanthipeptide

Lanthipeptides: AOX59_RS09365_lanthipeptide

1

GDVTPQATPTVTILATAAGGAVISAVLPTLKCSSKC

36

GDV PQ TP+ + A G AV + PT KC+S+C

1

GDVDPQTTPS----SVACGIAVSALFCPTTKCTSQC

32

42.5%

NZ_CP036019.1and 1 other:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27205_lanthipeptide

Lanthipeptides: EXW52_RS27205_lanthipeptide

1

GDVTPQATP-TVTILATAAGGAVISAVLPTLKCSSKC

36

GDV+P+ TP T TI+ A+ + PT KC+SKC

1

GDVSPETTPATPTIVV-----AISVGLCPTTKCTSKC

32

42.5%

NZ_JAQDYA010000001.1:

Lanthipeptides: PGT72_RS00025_lanthipeptide

1

GDVTPQATP----TVTILATAAGG--AVISAVLPTLKC

32

GD+TP+ TP TV A AG AV VL KC

1

GDITPETTPVCAATVASSAYCAGAASAVSGIVLSVFKC

38

42.5%

Lanthipeptides: COD66_RS20140_lanthipeptide

1

GDVTPQATP-TVTILATAAGGAVISAVLPTLKCSSKC

36

GDV+P+ TP T TI+ + G + PT KC+SKC

1

GDVSPETTPATPTIVVGISVG-----LCPTTKCTSKC

32

42.5%

NZ_NVJC01000007.1:

Lanthipeptides: COM38_RS07270_lanthipeptide

1

GDVTPQATPTVTILATAAGGAVISAVLPTLKC

32

GDV P+ TPT + T GA IS V PT KC

1

GDVNPETTPTTATVTTVLVGATIS-VCPTTKC

31

40.0%

NC_006322.1and 7 others:

NC_006322.1 Lanthipeptides: BLI_RS20290_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptide

Lanthipeptides: BLI_RS20290_lanthipeptide

1

GDVTPQATPTVTILATA--AGGAVISAVLPTLKCSSKC

36

DV P+ TP T T AG V +++ PT KC+S+C

1

NDVNPETTPATTSSWTCITAGVTVSASLCPTTKCTSRC

38

MIBiG 4.0 matches for WR47_RS28830

32.5%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

13

ILATAAGGAV--ISAVLPTLKCSSKC

36

I+A AG AV +A PT KC+S+C

12

IVAIQAGVAVGVSAAFCPTTKCTSRC

37

17.5%

Lanthipeptide: birimositide

26

VLPTLKCSSKC

36

PT KC+SKC

16

FCPTTKCTSKC

26

WR47_RS33320

Leader:

MERVQAIYS

Core:

NQKFKSWVKQVLAVGGVIGCCYLVLYVFCFLVIM

Core with dehydrations:

NQKFKDhaWVKQVLAVGGVIGCysCysYLVLYVFCysFLVIM

antiSMASH-DB 4.0 matches for WR47_RS33320

100.0%

NZ_CP011152.1:

Lanthipeptides: WR47_RS33320_lanthipeptide

1

NQKFKSWVKQVLAVGGVIGCCYLVLYVFCFLVIM

34

NQKFKSWVKQVLAVGGVIGCCYLVLYVFCFLVIM

1

NQKFKSWVKQVLAVGGVIGCCYLVLYVFCFLVIM

34

16.7%

NZ_CP051884.1:

Lanthipeptides: allorf_3277747_3277950_lanthipeptide

4

FKSWVKQVLAVGGVIGCCYLV

24

F+ W+ + + V V GC LV

27

FQRWLPRKVGVQVVHGCRQLV

47

MIBiG 4.0 matches for WR47_RS33320

14.7%

Lanthipeptide: birimositide

13

AVGGVIGCCYLV

24

A+G G C L

11

ALGNNGGWCTLT

22

allorf_299763_299852

Leader:

MFKKEYFRIYIIAAVLGS

Core:

LLTCFYYYYYK

Core with dehydrations:

LLDhbCysFYYYYYK

antiSMASH-DB 4.0 matches for allorf_299763_299852

100.0%

NZ_CP011152.1:

Lanthipeptides: allorf_299763_299852_lanthipeptide

1

LLTCFYYYYYK

11

LLTCFYYYYYK

1

LLTCFYYYYYK

11

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.57 out of 25.31

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.10 out of 23.79

Confidence: medium

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.16 out of 18.46

Confidence: medium

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 25.31 out of 28.14

Confidence: medium

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 24.56 out of 29.25

Confidence: medium

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.24 out of 29.25

Confidence: medium

Additional weak hits (4):

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.30 out of 27.04

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 21.71 out of 33.73

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.95 out of 20.01

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

WR47_RS28810 - Class II

Cleavage pHMM score: 0.50

RODEO score: 0

Monoisotopic mass: 6297.2 Da

Molecular weight: 6301.0 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 6319.0 Da N = 1; 6337.0 Da N = 2; 6355.1 Da N = 3; 6373.1 Da N = 4; 6391.1 Da N = 5; 6409.1 Da N = 6; 6427.1 Da N = 7

WR47_RS28815 - Class II

Cleavage pHMM score: 0.50

RODEO score: 0

Monoisotopic mass: 6506.2 Da

Molecular weight: 6510.2 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 6528.2 Da N = 1; 6546.2 Da N = 2; 6564.3 Da N = 3; 6582.3 Da N = 4; 6600.3 Da N = 5; 6618.3 Da N = 6; 6636.3 Da N = 7

WR47_RS28820 - Class II

Cleavage pHMM score: 0.50

RODEO score: 0

Monoisotopic mass: 6506.2 Da

Molecular weight: 6510.2 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 6528.2 Da N = 1; 6546.2 Da N = 2; 6564.3 Da N = 3; 6582.3 Da N = 4; 6600.3 Da N = 5; 6618.3 Da N = 6; 6636.3 Da N = 7

WR47_RS28825 - Class II

Cleavage pHMM score: 3.50

RODEO score: 0

Monoisotopic mass: 3169.7 Da

Molecular weight: 3171.6 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3189.6 Da N = 1; 3207.6 Da N = 2; 3225.7 Da N = 3; 3243.7 Da N = 4; 3261.7 Da N = 5; 3279.7 Da N = 6; 3297.7 Da N = 7

WR47_RS28830 - Class II

Cleavage pHMM score: 3.60

RODEO score: 0

Monoisotopic mass: 3746.1 Da

Molecular weight: 3748.3 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3766.4 Da N = 1; 3784.4 Da N = 2; 3802.4 Da N = 3; 3820.4 Da N = 4; 3838.4 Da N = 5; 3856.5 Da N = 6; 3874.5 Da N = 7; 3892.5 Da N = 8

WR47_RS28835 - Class II

Cleavage pHMM score: 3.60

RODEO score: 0

Monoisotopic mass: 3746.1 Da

Molecular weight: 3748.3 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3766.4 Da N = 1; 3784.4 Da N = 2; 3802.4 Da N = 3; 3820.4 Da N = 4; 3838.4 Da N = 5; 3856.5 Da N = 6; 3874.5 Da N = 7; 3892.5 Da N = 8

WR47_RS33320 - Class II

Cleavage pHMM score: -4.10

RODEO score: 0

Monoisotopic mass: 3849.1 Da

Molecular weight: 3851.7 Da

Number of bridges: 1

allorf_299763_299852 - Class II

Cleavage pHMM score: -4.00

RODEO score: 0

Monoisotopic mass: 1520.7 Da

Molecular weight: 1521.8 Da

Number of bridges: 1

WR47_RS28810 - Class II

Cleavage pHMM score: 0.50

RODEO score: 0

Monoisotopic mass: 6297.2 Da

Molecular weight: 6301.0 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 6319.0 Da N = 1; 6337.0 Da N = 2; 6355.1 Da N = 3; 6373.1 Da N = 4; 6391.1 Da N = 5; 6409.1 Da N = 6; 6427.1 Da N = 7

WR47_RS28815 - Class II

Cleavage pHMM score: 0.50

RODEO score: 0

Monoisotopic mass: 6506.2 Da

Molecular weight: 6510.2 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 6528.2 Da N = 1; 6546.2 Da N = 2; 6564.3 Da N = 3; 6582.3 Da N = 4; 6600.3 Da N = 5; 6618.3 Da N = 6; 6636.3 Da N = 7

WR47_RS28820 - Class II

Cleavage pHMM score: 0.50

RODEO score: 0

Monoisotopic mass: 6506.2 Da

Molecular weight: 6510.2 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 6528.2 Da N = 1; 6546.2 Da N = 2; 6564.3 Da N = 3; 6582.3 Da N = 4; 6600.3 Da N = 5; 6618.3 Da N = 6; 6636.3 Da N = 7

WR47_RS28825 - Class II

Cleavage pHMM score: 3.50

RODEO score: 0

Monoisotopic mass: 3169.7 Da

Molecular weight: 3171.6 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3189.6 Da N = 1; 3207.6 Da N = 2; 3225.7 Da N = 3; 3243.7 Da N = 4; 3261.7 Da N = 5; 3279.7 Da N = 6; 3297.7 Da N = 7

WR47_RS28830 - Class II

Cleavage pHMM score: 3.60

RODEO score: 0

Monoisotopic mass: 3746.1 Da

Molecular weight: 3748.3 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3766.4 Da N = 1; 3784.4 Da N = 2; 3802.4 Da N = 3; 3820.4 Da N = 4; 3838.4 Da N = 5; 3856.5 Da N = 6; 3874.5 Da N = 7; 3892.5 Da N = 8

WR47_RS28835 - Class II

Cleavage pHMM score: 3.60

RODEO score: 0

Monoisotopic mass: 3746.1 Da

Molecular weight: 3748.3 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3766.4 Da N = 1; 3784.4 Da N = 2; 3802.4 Da N = 3; 3820.4 Da N = 4; 3838.4 Da N = 5; 3856.5 Da N = 6; 3874.5 Da N = 7; 3892.5 Da N = 8

allorf_279614_279820 - Class II

Cleavage pHMM score: -7.30

RODEO score: 0

Monoisotopic mass: 5490.2 Da

Molecular weight: 5493.7 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 5511.7 Da N = 1; 5529.7 Da N = 2; 5547.7 Da N = 3; 5565.8 Da N = 4; 5583.8 Da N = 5; 5601.8 Da N = 6; 5619.8 Da N = 7; 5637.8 Da N = 8; 5655.9 Da N = 9; 5673.9 Da N = 10; 5691.9 Da N = 11; 5709.9 Da N = 12

allorf_280153_280365 - Class II

Cleavage pHMM score: -7.20

RODEO score: 0

Monoisotopic mass: 4225.1 Da

Molecular weight: 4227.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 4245.7 Da N = 1; 4263.8 Da N = 2; 4281.8 Da N = 3; 4299.8 Da N = 4; 4317.8 Da N = 5

allorf_299763_299852 - Class II

Cleavage pHMM score: -4.00

RODEO score: 0

Monoisotopic mass: 1520.7 Da

Molecular weight: 1521.8 Da

Number of bridges: 1

TFBS definitions

Regulator	Description
CatR	H2O2-responsive repressor
IolR	Regulator of the inositol catabolism
PerR	Peroxide regulator
RpoN	Regulator of nitrogen assimilation and virulence
SypG	Regulator of biofilm formation and host colonization

NZ_CP011152.1 - Region 4 - NRPS,T1PKS

Download region SVG

Location: 367,309 - 471,232 nt. (total: 103,924 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

WR47_RS29175: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

WR47_RS29220: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

WR47_RS29235: 3-hydroxybutyryl-CoA dehydrogenase

smcogs: SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase

WR47_RS29245: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

WR47_RS29260: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

WR47_RS29310: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

Transferases: PPTase acylase aminotransferase carbamoyltransferase

WR47_RS29230: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

WR47_RS29290: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

WR47_RS29300: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

WR47_RS29320: ornithine carbamoyltransferase

smcogs: SMCOG1114: ornithine carbamoyltransferase

Hydrolases: deaminase esterase hydrolase phosphatase

WR47_RS29265: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

WR47_RS29270: FkbH like protein

smcogs: SMCOG1256: FkbH like protein

WR47_RS29280: thioesterase

smcogs: SMCOG1004: thioesterase

WR47_RS29305: hydrolase

smcogs: SMCOG1179: hydrolase

WR47_RS29330: ornithine cyclodeaminase

smcogs: SMCOG1158: ornithine cyclodeaminase

Lyases: decarboxylase

WR47_RS29170: Decarboxylase, pyridoxal-dependent

smcogs: SMCOG1180: Decarboxylase, pyridoxal-dependent

Ligases: ligase synthase

WR47_RS29180: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

WR47_RS29200: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

WR47_RS29205: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

WR47_RS29210: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

WR47_RS29250: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

WR47_RS29255: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

WR47_RS29275: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

WR47_RS29285: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

WR47_RS29325: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001059.5	1.44	NRPS, PKS	zwittermicin A	Bacillus cereus
BGC0001833.4	0.94	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.90	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002286.3	0.89	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.89	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.89	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001135.5	0.89	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001758.4	0.86	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002075.3	0.86	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001825.4	0.84	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001059.5	0.95	NRPS, PKS	zwittermicin A	Bacillus cereus
BGC0001833.4	0.77	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.75	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002286.3	0.75	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.75	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.75	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001135.5	0.75	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001758.4	0.74	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002075.3	0.74	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001825.4	0.73	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0

Similar subclusters

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 25.18 out of 26.06

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.62 out of 27.78

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.71 out of 27.78

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.01 out of 32.93

Confidence: medium

Additional weak hits (8):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.04 out of 28.14

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 27.05 out of 39.62

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.19 out of 28.14

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.72 out of 32.74

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.81 out of 27.55

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 22.66 out of 26.12

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.13 out of 29.38

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 24.42 out of 35.63

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 4, location 367308 - 471232:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - Tyr) + (ohmal - bOH-Tyr) + (Pro) + (X - ohmal) + (D-Asn) + (X - X)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

WR47_RS29180: X - Tyr

Search NORINE for peptide: strict or relaxed

AMP-binding (477..877): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LSVAFDASIMEPVLFVGGELNAYGPTETTVCATM
Nearest Stachelhaus code(s):: Leu DAMLVGAVCK (71% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (1540..1944): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: LWRYFDSSVSESDLIMGGEVNEYGPTEATVSAMY
Nearest Stachelhaus code(s):: Lys DAEDIGTVSK (65% 8Å match)
Stachelhaus code match:: 70% (weak)

WR47_RS29200: mal

PKS_AT (1897..2192): mal

ATSignature: 2-Rhyd-Malonyl-CoA

Top 3 matches:: 2-Rhyd-Malonyl-CoA: 95.8%; Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 106.8
inactive: 74.2
Methoxymalonyl-CoA: 53.5
Methylmalonyl-CoA: 44.8
Propionyl-CoA: 31.2
CHC-CoA: 15.3
Ethylmalonyl-CoA: 14.8
Isobutyryl-CoA: 13.3
2-Methylbutyryl-CoA: 11.6
3-Methylbutyryl-CoA: 9.7
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0

WR47_RS29205: bOH-Tyr - Pro

Search NORINE for peptide: strict or relaxed

AMP-binding (274..685): bOH-Tyr

nrpys: bOH-Tyr

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LGLSFDASVQNGDGIIAGETNAYGPTETTVDSTC
Nearest Stachelhaus code(s):: bOH-Tyr DASTIAAVDK (62% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (1329..1728): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: FSMTFDVSVLEGNFLLAGEENMYGPTEATVIAST
Nearest Stachelhaus code(s):: Ala DVHNLAIVYK (76% 8Å match); Ser DVWNVAMVHK (62% 8Å match)
Stachelhaus code match:: 70% (weak)

WR47_RS29230: mal

PKS_AT (5..291): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 51.2
inactive: 31.2
Methoxymalonyl-CoA: 30.8
Methylmalonyl-CoA: 13.8
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

WR47_RS29250: Ser

Search NORINE for peptide: strict or relaxed

AMP-binding (8..410): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWEWHFFVSGETNLYGPTEATIDVTA
Nearest Stachelhaus code(s):: Ser DVWHFSLIDK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

WR47_RS29255: X - mal

AMP-binding (448..845): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LHQHFDMSVWEGNQTFGGEVNMYGITETTVHVTY
Nearest Stachelhaus code(s):: Ser DMWNTGLVHK (82% 8Å match)
Stachelhaus code match:: 90% (moderate)

PKS_AT (1551..1847): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 136.6
inactive: 96.6
Methoxymalonyl-CoA: 45.5
Methylmalonyl-CoA: 26.7
Propionyl-CoA: 16.8
Isobutyryl-CoA: 9.2
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

WR47_RS29275: Asn

Search NORINE for peptide: strict or relaxed

AMP-binding (461..856): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: YWASFDLTVTSTKVIVGGEINEYGPTETVVGCMI
Nearest Stachelhaus code(s):: Asn DLTKIGEVGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

WR47_RS29285: X - X

AMP-binding (280..682): X

nrpys: Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: FAMSFDVTIFEVYIFVGVELNLYGPTEATVCCTS
Nearest Stachelhaus code(s):: Met DVFYLGGVFK (59% 8Å match); Ala DVFFVGLVAK (50% 8Å match); Pro DLFYLALVCK (47% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (1323..1725): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: FAMSFDVTIFEVYILVGVELNGYGPTEATVCCTT
Nearest Stachelhaus code(s):: Met DVFYLGGVFK (62% 8Å match)
Stachelhaus code match:: 90% (moderate)