Select genomic region:
Overview
1.1
1.2
1.3
1.4
1.5
1.6
1.7
1.8
1.9
1.10
1.11
1.12
1.13
2.1
2.2
2.3
2.4

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP011151.1 (Bacillus cereus)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | NRPS-like | 414,928 | 458,509 |
Region 1.2 | NRPS,transAT-PKS | 537,576 | 611,705 |
Region 1.3 | azole-containing-RiPP | 1,297,150 | 1,320,656 |
Region 1.4 | NI-siderophore | 1,933,709 | 1,965,416 | High | petrobactin | other:other
Region 1.5 | NRP-metallophore,NRPS | 2,256,093 | 2,307,841 | High | bacillibactin | NRPS:Type I
Region 1.6 | NRPS | 2,444,762 | 2,510,670 |
Region 1.7 | betalactone | 2,565,364 | 2,590,602 | Low | fengycin | NRPS:Type I
Region 1.8 | RiPP-like | 2,646,263 | 2,656,586 |
Region 1.9 | RiPP-like | 2,753,177 | 2,763,443 |
Region 1.10 | NRPS | 2,782,264 | 2,829,274 |
Region 1.11 | terpene | 3,604,760 | 3,626,613 | Low | molybdenum cofactor | other:other
Region 1.12 | lanthipeptide-class-i | 3,691,416 | 3,717,859 |
Region 1.13 | terpene-precursor | 4,262,648 | 4,283,538 |  |

NZ_CP011152.1 (Bacillus cereus)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 2.1 | NRPS | 41,817 | 98,035 |
Region 2.2 | RiPP-like | 255,137 | 267,356 |
Region 2.3 | lanthipeptide-class-ii | 278,262 | 307,122 |
Region 2.4 | NRPS,T1PKS | 367,309 | 471,232 | High | zwittermicin A | NRPS:Type I+PKS

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | NRPS-like | 414,928 | 458,509 |
Region 1.2 | NRPS,transAT-PKS | 537,576 | 611,705 |
Region 1.3 | azole-containing-RiPP | 1,297,150 | 1,320,656 |
Region 1.4 | NI-siderophore | 1,933,709 | 1,965,416 | High | petrobactin | other:other
Region 1.5 | NRP-metallophore,NRPS | 2,256,093 | 2,307,841 | High | bacillibactin | NRPS:Type I
Region 1.6 | NRPS | 2,444,762 | 2,510,670 |
Region 1.7 | betalactone | 2,565,364 | 2,590,602 | Low | fengycin | NRPS:Type I
Region 1.8 | RiPP-like | 2,646,263 | 2,656,586 |
Region 1.9 | RiPP-like | 2,753,177 | 2,763,443 |
Region 1.10 | NRPS | 2,782,264 | 2,829,274 |
Region 1.11 | terpene | 3,604,760 | 3,626,613 | Low | molybdenum cofactor | other:other
Region 1.12 | lanthipeptide-class-i | 3,691,416 | 3,717,859 |
Region 1.13 | terpene-precursor | 4,262,648 | 4,283,538 |  |
Region 2.1 | NRPS | 41,817 | 98,035 |
Region 2.2 | RiPP-like | 255,137 | 267,356 |
Region 2.3 | lanthipeptide-class-ii | 278,262 | 307,122 |
Region 2.4 | NRPS,T1PKS | 367,309 | 471,232 | High | zwittermicin A | NRPS:Type I+PKS

Compact view
NZ_CP011151.1 - Region 1 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 414,928 - 458,509 nt. (total: 43,582 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidase
WR47_RS02155: FAD linked oxidase domain protein

smcogs
  SMCOG1138: FAD linked oxidase domain protein

Transferases: phosphorylase phosphotransferase
WR47_RS02165: Glucose-specific phosphotransferase enzyme IIA

smcogs
  SMCOG1145: Glucose-specific phosphotransferase enzyme IIA

WR47_RS02190: thiamine-phosphate pyrophosphorylase

smcogs
  SMCOG1280: thiamine-phosphate pyrophosphorylase

Hydrolases: glucosidase
WR47_RS02160: Alpha-glucosidase

smcogs
  SMCOG1257: Alpha-glucosidase

Ligases: ligase
WR47_RS02205: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.61 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0000307.4 |  | 0.60 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001132.4 |  | 0.60 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001166.5 |  | 0.60 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001128.4 |  | 0.60 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.60 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3 |  | 0.60 | NRPS | AM-toxin | Alternaria alternata
BGC0001250.4 |  | 0.60 | NRPS | epichloenin A | Epichloe festucae
BGC0001251.4 |  | 0.60 | NRPS | epichloenin A | Epichloe festucae
BGC0001758.4 |  | 0.59 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.61 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0000307.4 |  | 0.60 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001132.4 |  | 0.60 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001166.5 |  | 0.60 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001128.4 |  | 0.60 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.60 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3 |  | 0.60 | NRPS | AM-toxin | Alternaria alternata
BGC0001250.4 |  | 0.60 | NRPS | epichloenin A | Epichloe festucae
BGC0001251.4 |  | 0.60 | NRPS | epichloenin A | Epichloe festucae
BGC0001758.4 |  | 0.59 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.69 out of 21.55
Confidence: strong
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 25.04 out of 26.12
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.83 out of 27.78
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.81 out of 20.97
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.18 out of 23.79
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.96 out of 20.97
Confidence: medium
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 22.91 out of 25.88
Confidence: medium
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 22.91 out of 25.88
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.69 out of 27.55
Confidence: medium
Additional weak hits (10):
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.78 out of 31.73
Confidence: weak
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.11 out of 20.47
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.95 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.17 out of 32.74
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.89 out of 30.25
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.70 out of 25.75
Confidence: weak
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.13 out of 25.88
Confidence: weak
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.13 out of 25.88
Confidence: weak
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.06 out of 29.72
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.98 out of 33.14
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 414927 - 458509:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
WR47_RS02205: X
AMP-binding (225..621): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LWMPFDASVWEAALAIGGEHNVYGPTECTVVTTT
  Nearest Stachelhaus code(s):
    Leu DAWYLGNVVK (71% 8Å match)
  Stachelhaus code match:
    70% (weak)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM | Regulator of nitrogen-fixation genes
IolR | Regulator of the inositol catabolism
LuxO | Repressor of luminescence
PsrA | Oleic acid responsive regulator

NZ_CP011151.1 - Region 2 - NRPS,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 537,576 - 611,705 nt. (total: 74,130 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: PPTase acylase acyltransferase
WR47_RS02840: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

WR47_RS02855: polyketide synthase associated protein papA3

smcogs
  SMCOG1209: polyketide synthase associated protein papA3

WR47_RS02860: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: esterase
WR47_RS02845: thioesterase

smcogs
  SMCOG1004: thioesterase

Lyases: cyclase
WR47_RS02820: diguanylate cyclase

smcogs
  SMCOG1025: diguanylate cyclase

Ligases: ligase synthase
WR47_RS02850: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

WR47_RS02865: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

WR47_RS02870: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | transAT-PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0002135.2 |  |  | 0.86 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001135.5 |  |  | 0.83 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001833.4 |  |  | 0.78 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001758.4 |  |  | 0.77 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001128.4 |  |  | 0.77 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  |  | 0.77 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  |  | 0.75 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0000307.4 |  |  | 0.71 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001825.4 |  |  | 0.71 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001641.4 |  |  | 0.69 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.75 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001135.5 |  | 0.74 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001128.4 |  | 0.73 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.72 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  | 0.72 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.72 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001758.4 |  | 0.72 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001133.4 |  | 0.71 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0002071.2 |  | 0.70 | NRPS | virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D | Pseudomonas sp. QS1027
BGC0001166.5 |  | 0.70 | NRPS | HC-toxin | Alternaria jesenskae

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 25.42 out of 26.06
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.33 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.63 out of 27.78
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 28.43 out of 29.38
Confidence: strong
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 24.43 out of 24.78
Confidence: strong
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.73 out of 28.19
Confidence: strong
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.28 out of 19.52
Confidence: medium
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.67 out of 25.31
Confidence: medium
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.94 out of 25.31
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.33 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.19 out of 29.38
Confidence: medium
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.68 out of 28.14
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.23 out of 27.78
Confidence: medium
Additional weak hits (8):
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 20.16 out of 29.72
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 26.40 out of 36.54
Confidence: weak
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.88 out of 27.55
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 16.99 out of 30.12
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 17.35 out of 30.12
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.47 out of 26.85
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.53 out of 29.25
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.41 out of 29.65
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 537575 - 611705:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Leu - D-Val) + (Asp - Thr - Leu - Val - Leu) + (ccmal) + (ccmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 537575 - 600831:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Leu - D-Val) + (Asp - Thr - Leu - Val - Leu) + (ccmal) + (ccmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 560831 - 611705:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Leu - D-Val) + (Asp - Thr - Leu - Val - Leu) + (ccmal) + (ccmal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
WR47_RS02850: Leu - Val
Search NORINE for peptide: strict or relaxed
AMP-binding (275..658): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LWAVFDPWALEPALITGGDFNNYGPTEHTVVTTN
  Nearest Stachelhaus code(s):
    Trp DAACIGNVVK (68% 8Å match)
    Leu DALLIGAVVK (47% 8Å match)
  Stachelhaus code match:
    70% (weak)

AMP-binding (1300..1703): Val
nrpys: Val

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    val (Val)

Stachelhaus prediction details:
  Stachelhaus sequence:
    VDTAFDGSTFDGFVIVGGDINGYGPTESTVFATA
  Nearest Stachelhaus code(s):
    Val DGFFVGGVFK (65% 8Å match)
  Stachelhaus code match:
    90% (moderate)

WR47_RS02855: Asp - Thr - Leu - Val - Leu
Search NORINE for peptide: strict or relaxed
AMP-binding (470..875): Asp
nrpys: Asp

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asp (Asp)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWFSFDLGYTSSKLVLGGEMNHYGPTETTIGAIA
  Nearest Stachelhaus code(s):
    Asp DLTKVGHIGK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1517..1922): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LATHFDFSVWEGNQIFGGEVNMYGITETTVHVTY
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (2564..2947): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LWHAFDASSWEPFLLTGGDFNNYGPTENTVVTTT
  Nearest Stachelhaus code(s):
    Leu DAWFLGNVVK (88% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (3589..3992): Val
nrpys: Val

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    val (Val)

Stachelhaus prediction details:
  Stachelhaus sequence:
    VDTAFDGSTFDGFVIVGGDINGYGPTESTVFATA
  Nearest Stachelhaus code(s):
    Val DGFFVGGVFK (65% 8Å match)
  Stachelhaus code match:
    90% (moderate)

AMP-binding (4634..5017): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LWHAFDASSWEPFLLTGGDFNNYGPTENTVVTTT
  Nearest Stachelhaus code(s):
    Leu DAWFLGNVVK (88% 8Å match)
  Stachelhaus code match:
    100% (strong)

WR47_RS02860: mal
PKS_AT (6..290): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 79.2%
  inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 105.0
  inactive: 43.4
  Methoxymalonyl-CoA: 41.1
  Methylmalonyl-CoA: 36.2
  Ethylmalonyl-CoA: 23.1
  Propionyl-CoA: 15.3
  2-Methylbutyryl-CoA: 11.3
  fatty_acid: 11.2
  Benzoyl-CoA: 9.3
  Isobutyryl-CoA: 8.9
  trans-1,2-CPDA: 0.0
  CHC-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsQ1 | Two-component system AfsQ1-Q2, activator of antibiotic production
CatR | H2O2-responsive repressor
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
PerR | Peroxide regulator
ZuR variant 1 | Zinc-responsive repressor

NZ_CP011151.1 - Region 3 - azole-containing-RiPP
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,297,150 - 1,320,656 nt. (total: 23,507 nt) Show pHMM detection rules used
azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Azole RiPPs
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
WR47_RS06355: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: methyltransferase
WR47_RS06370: methyltransferase

smcogs
  SMCOG1089: methyltransferase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | azole-containing-RiPP | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002013.4 |  | 0.46 | ribosomal | curacozole | Streptomyces curacoi
BGC0001174.4 |  | 0.44 | ribosomal | corynazolicin | Corynebacterium urealyticum DSM 7111
BGC0000607.5 |  | 0.43 | ribosomal | micrococcin P1 | Macrococcus caseolyticus
BGC0001146.5 |  | 0.43 | ribosomal | cyclothiazomycin C | Streptomyces sp. NRRL WC-3908
BGC0001535.3 |  | 0.43 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0001534.3 |  | 0.41 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0001173.5 |  | 0.41 | ribosomal | plantazolicin | Bacillus pumilus ATCC 7061
BGC0001145.5 |  | 0.40 | ribosomal | cyclothiazomycin b1 | Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0000603.5 |  | 0.39 | ribosomal | cyclothiazomycin | Streptomyces hygroscopicus
BGC0000606.5 |  | 0.39 | ribosomal | lactazole | Streptomyces lactacystinaeus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002013.4 |  | 0.46 | ribosomal | curacozole | Streptomyces curacoi
BGC0001174.4 |  | 0.44 | ribosomal | corynazolicin | Corynebacterium urealyticum DSM 7111
BGC0000607.5 |  | 0.43 | ribosomal | micrococcin P1 | Macrococcus caseolyticus
BGC0001146.5 |  | 0.43 | ribosomal | cyclothiazomycin C | Streptomyces sp. NRRL WC-3908
BGC0001535.3 |  | 0.43 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0001534.3 |  | 0.41 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0001173.5 |  | 0.41 | ribosomal | plantazolicin | Bacillus pumilus ATCC 7061
BGC0001145.5 |  | 0.40 | ribosomal | cyclothiazomycin b1 | Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0000603.5 |  | 0.39 | ribosomal | cyclothiazomycin | Streptomyces hygroscopicus
BGC0000606.5 |  | 0.39 | ribosomal | lactazole | Streptomyces lactacystinaeus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.11 out of 27.55
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.04 out of 23.79
Confidence: medium
Additional weak hits (3):
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.62 out of 29.25
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.69 out of 39.62
Confidence: weak
(Thi)azol(in)e containing peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Predicted tail sequences are also shown, if present.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
No core peptides found.
RREFinder
TFBS Finder
Azole RiPPs
RRE predictions
RREfinder results sidepanel.

azole-containing-RiPP protocluster (1297149...1320656)
WR47_RS06385
  RRE type: Heterocycloanthracin_C_RRE
  Location: 0 - 100
  Score: 181.5
  RRE type: Thiopeptide_F_RRE
  Location: 10 - 89
  Score: 41.0

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
GnfM | Regulator of nitrogen-fixation genes
IolR | Regulator of the inositol catabolism

Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.
NZ_CP011151.1 - Region 4 - NI-siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,933,709 - 1,965,416 nt. (total: 31,708 nt) Show pHMM detection rules used
NI-siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: aminotransferase
WR47_RS09725: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Hydrolases: deacetylase
WR47_RS09660: polysaccharide deacetylase

smcogs
  SMCOG1235: polysaccharide deacetylase

Ligases: ligase synthase
WR47_RS09620: cysteine synthase

smcogs
  SMCOG1081: cysteine synthase

WR47_RS09690: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NI-siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000942.4 |  | 0.89 | other (other) | petrobactin | Bacillus anthracis str. Ames
BGC0002469.2 |  | 0.54 | other (other) | woodybactin A, woodybactin B, woodybactin C, woodybactin D | Shewanella woodyi ATCC 51908
BGC0001572.3 |  | 0.51 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0000295.5 |  | 0.51 | NRPS | acinetoferrin | Acinetobacter haemolyticus
BGC0002692.2 |  | 0.50 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0002620.2 |  | 0.50 | other (other) | fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4 | Fulvivirga marina
BGC0001531.5 |  | 0.50 | other (other) | bisucaberin B | Tenacibaculum mesophilum
BGC0002305.2 |  | 0.50 | other (other) | legonoxamine A, desferrioxamine B, legonoxamine B | Streptomyces sp.
BGC0002464.3 |  | 0.48 | other (other) | alcaligin | Bordetella pertussis Tohama I
BGC0002633.2 |  | 0.47 | other (other) | schizokinen | Leptolyngbya sp. PCC 7376

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000942.4 |  | 0.89 | other (other) | petrobactin | Bacillus anthracis str. Ames
BGC0002469.2 |  | 0.54 | other (other) | woodybactin A, woodybactin B, woodybactin C, woodybactin D | Shewanella woodyi ATCC 51908
BGC0001572.3 |  | 0.51 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0000295.5 |  | 0.51 | NRPS | acinetoferrin | Acinetobacter haemolyticus
BGC0002692.2 |  | 0.50 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0002620.2 |  | 0.50 | other (other) | fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4 | Fulvivirga marina
BGC0001531.5 |  | 0.50 | other (other) | bisucaberin B | Tenacibaculum mesophilum
BGC0002305.2 |  | 0.50 | other (other) | legonoxamine A, desferrioxamine B, legonoxamine B | Streptomyces sp.
BGC0002464.3 |  | 0.48 | other (other) | alcaligin | Bordetella pertussis Tohama I
BGC0002633.2 |  | 0.47 | other (other) | schizokinen | Leptolyngbya sp. PCC 7376

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.14 out of 29.38
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.03 out of 20.97
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.38 out of 29.38
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.93 out of 28.19
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 15.13 out of 18.16
Confidence: strong
Additional weak hits (4):
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.58 out of 19.52
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.50 out of 32.74
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.66 out of 32.74
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.60 out of 36.54
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CcpA | Catabolite control protein A
FuR variant 1 | Ferric Uptake Regulator
ZuR variant 1 | Zinc-responsive repressor

NZ_CP011151.1 - Region 5 - NRP-metallophore,NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,256,093 - 2,307,841 nt. (total: 51,749 nt) Show pHMM detection rules used
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidase oxygenase
WR47_RS11300: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

WR47_RS11305: 3-hydroxyisobutyrate dehydrogenase

smcogs
  SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

WR47_RS11310: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

WR47_RS11365: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

WR47_RS11445: Antibiotic biosynthesis monooxygenase

smcogs
  SMCOG1258: Antibiotic biosynthesis monooxygenase

WR47_RS11475: pyruvate oxidase/decarboxylase

smcogs
  SMCOG1055: pyruvate oxidase/decarboxylase

Transferases: PPTase
WR47_RS11400: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: hydrolase protease
WR47_RS11380: isochorismatase

smcogs
  SMCOG1027: isochorismatase

WR47_RS11425: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: hydratase
WR47_RS11320: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Isomerases: isomerase
WR47_RS11370: isochorismate synthase

smcogs
  SMCOG1018: isochorismate synthase

Ligases: ligase synthase
WR47_RS11375: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

WR47_RS11385: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

WR47_RS11450: Pseudouridine synthase

smcogs
  SMCOG1154: Pseudouridine synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRP-metallophore | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001185.5 |  |  | 1.05 | NRPS | bacillibactin | Bacillus velezensis FZB42
BGC0000309.5 |  |  | 0.88 | NRPS | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5 |  |  | 0.86 | NRPS | paenibactin | Paenibacillus elgii B69
BGC0002075.3 |  |  | 0.86 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0000343.5 |  |  | 0.86 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0001132.4 |  |  | 0.77 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  |  | 0.75 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  |  | 0.74 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  |  | 0.74 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  |  | 0.72 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001185.5 |  | 0.80 | NRPS | bacillibactin | Bacillus velezensis FZB42
BGC0000309.5 |  | 0.75 | NRPS | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5 |  | 0.74 | NRPS | paenibactin | Paenibacillus elgii B69
BGC0002075.3 |  | 0.74 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0000343.5 |  | 0.74 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0001132.4 |  | 0.71 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.70 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  | 0.70 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  | 0.70 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.69 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.13 out of 27.78
Confidence: strong
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.21 out of 30.25
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.83 out of 27.78
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.53 out of 26.06
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.40 out of 29.38
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.20 out of 32.93
Confidence: medium
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.59 out of 23.05
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.53 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.41 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.90 out of 29.38
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.62 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.57 out of 27.78
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.56 out of 29.38
Confidence: medium
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.57 out of 32.74
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 25.99 out of 30.25
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.21 out of 30.25
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.53 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19
Confidence: medium
Additional weak hits (7):
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.83 out of 32.74
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.49 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.05 out of 29.38
Confidence: weak
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.72 out of 18.46
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.54 out of 30.25
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.85 out of 36.53
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.35 out of 31.73
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 7, location 2256092 - 2307841:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
WR47_RS11375: diOH-Bz
Search NORINE for peptide: strict or relaxed
AMP-binding (31..435): diOH-Bz
nrpys: diOH-Bz

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Small clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Single AA prediction:
    dhb (diOH-Bz)

Stachelhaus prediction details:
  Stachelhaus sequence:
    SVSLYPMSSPGGALQVGGAQQVFGMAEGLVNYTR
  Nearest Stachelhaus code(s):
    diOH-Bz PMPAQGVVNK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

WR47_RS11385: Gly - Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (464..864): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FAMTFDISALELQALVGGETNLYGPTETTIWSTF
  Nearest Stachelhaus code(s):
    Gly DILQLGLIWK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1524..1937): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LATHFDFSVWEGNQVFGGEINMYGITETTVHVSY
  Nearest Stachelhaus code(s):
    Thr DFWNVGMVHK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
FuR variant 1 | Ferric Uptake Regulator
FuR variant 2 | Ferric Uptake Regulator
LexA variant 3 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
ZuR variant 1 | Zinc-responsive repressor

NZ_CP011151.1 - Region 6 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,444,762 - 2,510,670 nt. (total: 65,909 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: PPTase acetyltransferase acyltransferase
WR47_RS12275: Chloramphenicol acetyltransferase

smcogs
  SMCOG1156: Chloramphenicol acetyltransferase

WR47_RS12285: acyltransferase 3

smcogs
  SMCOG1088: acyltransferase 3

WR47_RS12315: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: deacetylase esterase
WR47_RS12230: acetylornithine deacetylase

smcogs
  SMCOG1247: acetylornithine deacetylase

WR47_RS12320: thioesterase

smcogs
  SMCOG1004: thioesterase

Ligases: ligase
WR47_RS12300: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

WR47_RS12305: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

WR47_RS12310: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Translocases: permease
WR47_RS12355: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

WR47_RS12370: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.74 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001833.4 |  | 0.73 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001758.4 |  | 0.73 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001135.5 |  | 0.73 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001133.4 |  | 0.72 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0001128.4 |  | 0.71 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.71 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001166.5 |  | 0.70 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001132.4 |  | 0.70 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002071.2 |  | 0.70 | NRPS | virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D | Pseudomonas sp. QS1027

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.74 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001833.4 |  | 0.73 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001758.4 |  | 0.73 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001135.5 |  | 0.73 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001133.4 |  | 0.72 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0001128.4 |  | 0.71 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.71 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001166.5 |  | 0.70 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001132.4 |  | 0.70 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002071.2 |  | 0.70 | NRPS | virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D | Pseudomonas sp. QS1027

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.03 out of 26.06
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.21 out of 26.06
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.30 out of 26.06
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.34 out of 20.97
Confidence: medium
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 30.96 out of 36.54
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.01 out of 30.25
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.23 out of 26.06
Confidence: medium
Additional weak hits (5):
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.74 out of 31.73
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.09 out of 29.38
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 25.64 out of 31.73
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.08 out of 36.54
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 17.58 out of 30.12
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 8, location 2444761 - 2510670:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (D-Thr) + (X - Ala) + (Ser - Leu - D-X - Glu)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
WR47_RS12300: Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (457..866): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSTHFDFSVWEGNQIFGGEINMYGITETTVHVTY
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

WR47_RS12305: X - Ala
Search NORINE for peptide: strict or relaxed
AMP-binding (466..870): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWMTFDVSVWEWQFFSGGETNFYGPTEATIYVNA
  Nearest Stachelhaus code(s):
    Glu DVWHFGRINK (71% 8Å match)
    Gln DAWQFGLIDK (65% 8Å match)
  Stachelhaus code match:
    70% (weak)

AMP-binding (1527..1919): Ala
nrpys: Ala

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    ala (Ala)

Stachelhaus prediction details:
  Stachelhaus sequence:
    MWATFDLSVFEVNTNLAGEYNLYGPSEDTTYSTY
  Nearest Stachelhaus code(s):
    Ala DLFNNALTYK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

WR47_RS12310: Ser - Leu - X - Glu
Search NORINE for peptide: strict or relaxed
AMP-binding (496..901): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    ser (Ser)
  Single AA prediction:
    ser (Ser)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWMTFDVSFWEWHFFTSGEINLYGPTEATVDVTY
  Nearest Stachelhaus code(s):
    Ser DVWHFSLVDK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1558..1945): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    MWHAFDSAVQEPFAITGGDINQYGPSENTVVTTD
  Nearest Stachelhaus code(s):
    Pro DVQFIAQVVK (56% 8Å match)
  Stachelhaus code match:
    80% (moderate)

AMP-binding (2600..3000): X
nrpys: Gln, Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    glu (Glu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LGLAFDASIQQMDILVGGEYNVYGPTECTVDATC
  Nearest Stachelhaus code(s):
    Gln or Glu DAQDLGVVDK (88% 8Å match)
    Ile DAQDLGVVDK (85% 8Å match)
    Gln DAQDLGVVDK (79% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (4115..4515): Glu
nrpys: Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    N/A
  Single AA prediction:
    glu (Glu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LGLAFDVSIQQMDMLVGGEYNVYGPTECTVDATC
  Nearest Stachelhaus code(s):
    Gln or Glu DAQDLGVVDK (85% 8Å match)
    Ile DAQDLGVVDK (82% 8Å match)
    Gln DAQDLGVVDK (76% 8Å match)
  Stachelhaus code match:
    90% (moderate)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
ColR | Phenol-responsive regulator
HgtR | Hydrogen-dependent regulator
MogR | Repressor of flagellar motility genes

NZ_CP011151.1 - Region 7 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,565,364 - 2,590,602 nt. (total: 25,239 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
WR47_RS12620: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

Transferases: acetyltransferase carboxylase transferase
WR47_RS12625: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

WR47_RS12645: acetyl-CoA carboxylase, carboxyl transferase,

smcogs
  SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

WR47_RS12665: GCN5-related N-acetyltransferase

smcogs
  SMCOG1111: GCN5-related N-acetyltransferase

Lyases: hydratase
WR47_RS12640: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase
WR47_RS12635: 2-isopropylmalate synthase

smcogs
  SMCOG1271: 2-isopropylmalate synthase

WR47_RS12650: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002284.3 |  | 0.55 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000131.5 |  | 0.46 | PKS | pyrrolomycin | Streptomyces sp. UC 11065
BGC0000706.3 |  | 0.46 | saccharide | kanamycin | Streptomyces kanamyceticus
BGC0000234.5 |  | 0.43 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000623.3 |  | 0.42 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0001226.4 |  | 0.42 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0001103.5 |  | 0.42 | NRPS, PKS | mycosubtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000563.4 |  | 0.42 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0000558.5 |  | 0.42 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0002700.2 |  | 0.41 | ribosomal | bacinapeptin | Bacillus nakamurai

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002284.3 |  | 0.55 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000131.5 |  | 0.46 | PKS | pyrrolomycin | Streptomyces sp. UC 11065
BGC0000706.3 |  | 0.46 | saccharide | kanamycin | Streptomyces kanamyceticus
BGC0000234.5 |  | 0.43 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000623.3 |  | 0.42 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0001226.4 |  | 0.42 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0001103.5 |  | 0.42 | NRPS, PKS | mycosubtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000563.4 |  | 0.42 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0000558.5 |  | 0.42 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0002700.2 |  | 0.41 | ribosomal | bacinapeptin | Bacillus nakamurai

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.06 out of 19.26
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.51 out of 27.55
Confidence: medium
Additional weak hits (1):
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.65 out of 33.14
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
GnfM | Regulator of nitrogen-fixation genes
ToxT | Regulator of MSHA biosynthesis

NZ_CP011151.1 - Region 8 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,646,263 - 2,656,586 nt. (total: 10,324 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: aminotransferase
WR47_RS12950: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000896.5 |  | 0.29 | other (other) | cycloserine | Streptomyces lavendulae subsp. lavendulae
BGC0000721.4 |  | 0.26 | saccharide | tobramycin | Streptoalloteichus tenebrarius
BGC0000172.5 |  | 0.23 | PKS | Basiliskamide A, Basiliskamide B | Brevibacillus laterosporus PE36
BGC0000381.5 |  | 0.23 | NRPS | lichenysin | Bacillus licheniformis DSM 13 = ATCC 14580
BGC0000433.5 |  | 0.22 | NRPS | surfactin | Bacillus velezensis FZB42
BGC0000455.6 |  | 0.22 | NRPS, saccharide | vancomycin | Amycolatopsis orientalis HCCB10007 (ATCC43491)
BGC0002588.2 |  | 0.22 | other (other) | enduracididine | uncultured bacterium
BGC0001233.5 |  | 0.22 | NRPS | feglymycin | Streptomyces sp. DSM 11171
BGC0001461.5 |  | 0.21 | NRPS | Actinoidin B | Amycolatopsis keratiniphila subsp. nogabecina
BGC0001459.5 |  | 0.21 | NRPS | decaplanin | Amycolatopsis regifaucium

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000896.5 |  | 0.29 | other (other) | cycloserine | Streptomyces lavendulae subsp. lavendulae
BGC0000721.4 |  | 0.26 | saccharide | tobramycin | Streptoalloteichus tenebrarius
BGC0000172.5 |  | 0.23 | PKS | Basiliskamide A, Basiliskamide B | Brevibacillus laterosporus PE36
BGC0000381.5 |  | 0.23 | NRPS | lichenysin | Bacillus licheniformis DSM 13 = ATCC 14580
BGC0000433.5 |  | 0.22 | NRPS | surfactin | Bacillus velezensis FZB42
BGC0000455.6 |  | 0.22 | NRPS, saccharide | vancomycin | Amycolatopsis orientalis HCCB10007 (ATCC43491)
BGC0002588.2 |  | 0.22 | other (other) | enduracididine | uncultured bacterium
BGC0001233.5 |  | 0.22 | NRPS | feglymycin | Streptomyces sp. DSM 11171
BGC0001461.5 |  | 0.21 | NRPS | Actinoidin B | Amycolatopsis keratiniphila subsp. nogabecina
BGC0001459.5 |  | 0.21 | NRPS | decaplanin | Amycolatopsis regifaucium

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.24 out of 21.55
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.87 out of 32.93
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.30 out of 26.06
Confidence: medium
Additional weak hits (2):
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.27 out of 25.75
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 17.35 out of 30.12
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
LexA variant 3 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes

NZ_CP011151.1 - Region 9 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,753,177 - 2,763,443 nt. (total: 10,267 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: hydrolase
WR47_RS13560: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.

No matches found.

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
No hits above weak threshold.
Weak hits (2):
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.40 out of 36.53
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.64 out of 32.74
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---

NZ_CP011151.1 - Region 10 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,782,264 - 2,829,274 nt. (total: 47,011 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase
WR47_RS13725: FAD dependent oxidoreductase

smcogs
  SMCOG1103: FAD dependent oxidoreductase

WR47_RS13875: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs
  SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: aminotransferase
WR47_RS13870: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Hydrolases: esterase glucanase hydrolase
WR47_RS13805: alpha/beta hydrolase domain-containing protein

smcogs
  SMCOG1066: alpha/beta hydrolase domain-containing protein

WR47_RS13825: Pullulanase, type I

smcogs
  SMCOG1297: Pullulanase, type I

WR47_RS13835: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

smcogs
  SMCOG1283: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

WR47_RS13880: alpha/beta hydrolase fold protein

smcogs
  SMCOG1036: alpha/beta hydrolase fold protein

Lyases: decarboxylase
WR47_RS13810: Decarboxylase, pyridoxal-dependent

smcogs
  SMCOG1180: Decarboxylase, pyridoxal-dependent

Ligases: ligase
WR47_RS13815: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001249.5 |  | 0.72 | NRPS | dimethylcoprogen | Alternaria alternata
BGC0001261.3 |  | 0.66 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  | 0.66 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  | 0.64 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.4 |  | 0.64 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.64 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4 |  | 0.63 | NRPS | AbT1 | Aureobasidium pullulans
BGC0002135.2 |  | 0.63 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0000357.5 |  | 0.62 | NRPS | cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val) | Penicillium rubens Wisconsin 54-1255
BGC0001641.4 |  | 0.62 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001249.5 |  | 0.72 | NRPS | dimethylcoprogen | Alternaria alternata
BGC0001261.3 |  | 0.66 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  | 0.66 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  | 0.64 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.4 |  | 0.64 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.64 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4 |  | 0.63 | NRPS | AbT1 | Aureobasidium pullulans
BGC0002135.2 |  | 0.63 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0000357.5 |  | 0.62 | NRPS | cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val) | Penicillium rubens Wisconsin 54-1255
BGC0001641.4 |  | 0.62 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.71 out of 26.33
Confidence: medium
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 24.13 out of 29.25
Confidence: medium
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 28.23 out of 31.73
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.81 out of 20.97
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.75 out of 28.19
Confidence: medium
Additional weak hits (6):
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.07 out of 32.74
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.69 out of 31.73
Confidence: weak
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 20.28 out of 29.72
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.46 out of 31.73
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.36 out of 33.73
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.63 out of 29.65
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 12, location 2782263 - 2829274:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X - Cys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
WR47_RS13815: X - Cys
Search NORINE for peptide: strict or relaxed
AMP-binding (266..656): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    FVMAFDISLLELESLLAGELNIYGPTETTICATV
  Nearest Stachelhaus code(s):
    Ala DILICALICK (44% 8Å match)
  Stachelhaus code match:
    70% (weak)

AMP-binding (1303..1683): Cys
nrpys: Cys

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Small clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Single AA prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TDISFDLSVYDGNTLHSGDISLGGATEASIWSIY
  Nearest Stachelhaus code(s):
    Cys DLYNLSLIWK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
CcpA | Catabolite control protein A
HexR | Glucose-responsive regulator
SypG | Regulator of biofilm formation and host colonization
ZuR variant 1 | Zinc-responsive repressor

NZ_CP011151.1 - Region 11 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,604,760 - 3,626,613 nt. (total: 21,854 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
WR47_RS17720: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

WR47_RS17725: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Lyases: lyase
WR47_RS17695: argininosuccinate lyase/adenylosuccinate lyase

smcogs
  SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000917.3 |  | 0.52 | other (other) | molybdenum cofactor | Rhodobacter capsulatus
BGC0000888.5 |  | 0.49 | other (other) | bacilysin | Bacillus sp. CS93
BGC0001928.2 |  | 0.46 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0000916.5 |  | 0.46 | other (other) | molybdenum cofactor | Staphylococcus carnosus
BGC0000812.3 |  | 0.45 | other (other) | huperzine A | Shiraia sp. slf14
BGC0000231.5 |  | 0.42 | PKS | griseusin A, griseusin B | Streptomyces griseus
BGC0001605.3 |  | 0.42 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0001197.5 |  | 0.42 | PKS | frankiamicin | Frankia sp. EAN1pec
BGC0000234.5 |  | 0.41 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0002138.2 |  | 0.40 | PKS | fuelimycin A, fuelimicin B, fuelimicin C | Streptomyces albireticuli NRRL B-1670

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000917.3 |  | 0.52 | other (other) | molybdenum cofactor | Rhodobacter capsulatus
BGC0000888.5 |  | 0.49 | other (other) | bacilysin | Bacillus sp. CS93
BGC0001928.2 |  | 0.46 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0000916.5 |  | 0.46 | other (other) | molybdenum cofactor | Staphylococcus carnosus
BGC0000812.3 |  | 0.45 | other (other) | huperzine A | Shiraia sp. slf14
BGC0000231.5 |  | 0.42 | PKS | griseusin A, griseusin B | Streptomyces griseus
BGC0001605.3 |  | 0.42 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0001197.5 |  | 0.42 | PKS | frankiamicin | Frankia sp. EAN1pec
BGC0000234.5 |  | 0.41 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0002138.2 |  | 0.40 | PKS | fuelimycin A, fuelimicin B, fuelimicin C | Streptomyces albireticuli NRRL B-1670

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene | hopanoid |  | C30 | hopanoid skeleton | unknown
triterpene | polypodane |  | C30 | polypodane skeleton | unknown

Genes with terpene domains:
WR47_RS17735: T2TS
Domain 1 (4 - 614): Type 2 terpene synthase
Subtype: Squalene substrate

Reactions:
  squalene → hopanoid
  squalene → polypodane

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 26.42 out of 30.22
Confidence: medium
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.
No acronyms to display
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ClgR | Caseinolytic protease gene regulator

NZ_CP011151.1 - Region 12 - lanthipeptide-class-i
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,691,416 - 3,717,859 nt. (total: 26,444 nt) Show pHMM detection rules used
lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: protease
WR47_RS18105: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase dehydratase
WR47_RS18150: Lanthionine synthetase C family protein

smcogs
  SMCOG1140: Lanthionine synthetase C family protein

WR47_RS18160: Lantibiotic dehydratase domain protein

smcogs
  SMCOG1155: Lantibiotic dehydratase domain protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-i | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002576.2 |  | 0.76 | ribosomal | mechercharmycin | Thermoactinomyces sp.
BGC0000541.5 |  | 0.61 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0000542.3 |  | 0.61 | ribosomal | paenicidin B | Paenibacillus terrae
BGC0001289.5 |  | 0.60 | ribosomal | penisin | Paenibacillus ehimensis
BGC0002668.2 |  | 0.56 | ribosomal | cesin A | Clostridium estertheticum
BGC0002640.2 |  | 0.56 | ribosomal | thalassomonasin A, thalassomonasin B | Thalassomonas actiniarum
BGC0002635.2 |  | 0.56 | ribosomal | daspyromycin A, daspyromycin B | Actinokineospora diospyrosa
BGC0001618.3 |  | 0.56 | ribosomal | hyicin 3682 | Staphylococcus hyicus
BGC0000560.5 |  | 0.55 | ribosomal | subtilomycin | Bacillus subtilis
BGC0000506.4 |  | 0.55 | ribosomal | entianin | Bacillus subtilis subsp. spizizenii

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002576.2 |  | 0.76 | ribosomal | mechercharmycin | Thermoactinomyces sp.
BGC0000541.5 |  | 0.61 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0000542.3 |  | 0.61 | ribosomal | paenicidin B | Paenibacillus terrae
BGC0001289.5 |  | 0.60 | ribosomal | penisin | Paenibacillus ehimensis
BGC0002668.2 |  | 0.56 | ribosomal | cesin A | Clostridium estertheticum
BGC0002640.2 |  | 0.56 | ribosomal | thalassomonasin A, thalassomonasin B | Thalassomonas actiniarum
BGC0002635.2 |  | 0.56 | ribosomal | daspyromycin A, daspyromycin B | Actinokineospora diospyrosa
BGC0001618.3 |  | 0.56 | ribosomal | hyicin 3682 | Staphylococcus hyicus
BGC0000560.5 |  | 0.55 | ribosomal | subtilomycin | Bacillus subtilis
BGC0000506.4 |  | 0.55 | ribosomal | entianin | Bacillus subtilis subsp. spizizenii

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for WR47_RS18160

WR47_RS18165
Leader:
MINEKNLFDLDVQVTTATGDVDPQ
WR47_RS18170
Leader:
MINEKNLFDLDVQVTTATGDVDPQ
WR47_RS18175
Leader:
MINEKNLFDLDVQVTTATGDVDPQ
WR47_RS18180
Leader:
MINEKNLFDLDVQVTTATGDVDPQ
Shared core:
I T S I S A C T P G C G N T G S F N S F C C
Core with dehydrations:
I Dhb Dha I Dha A Cys Dhb P G Cys G N Dhb G Dha F N Dha F Cys Cys

#### antiSMASH-DB 4.0 matches for WR47_RS18165

100.0%
NC_022873.1 and 92 others:
NZ_CM000742.1 Lanthipeptides: BMYCO0001_RS26515_lanthipeptide NZ_CP011151.1 Lanthipeptides: WR47_RS18180_lanthipeptide NZ_CP011151.1 Lanthipeptides: WR47_RS18175_lanthipeptide NZ_CP011151.1 Lanthipeptides: WR47_RS18170_lanthipeptide NZ_CP011151.1 Lanthipeptides: WR47_RS18165_lanthipeptide NZ_CP015350.1 Lanthipeptides: BT246_RS19775_lanthipeptide NZ_CP015350.1 Lanthipeptides: BT246_RS19770_lanthipeptide NZ_CP015350.1 Lanthipeptides: BT246_RS19765_lanthipeptide NZ_CP017060.1 Lanthipeptides: FORC47_RS18710_lanthipeptide NZ_CP017060.1 Lanthipeptides: FORC47_RS18705_lanthipeptide NZ_CP017060.1 Lanthipeptides: FORC47_RS18700_lanthipeptide NZ_CP026678.1 Lanthipeptides: C2I25_RS21370_lanthipeptide NZ_CP026678.1 Lanthipeptides: C2I25_RS21365_lanthipeptide NZ_CP026678.1 Lanthipeptides: C2I25_RS21360_lanthipeptide NZ_CP035965.1 Lanthipeptides: EXW35_RS16385_lanthipeptide NZ_CP035965.1 Lanthipeptides: EXW35_RS16380_lanthipeptide NZ_CP035994.1 Lanthipeptides: EXW32_RS16155_lanthipeptide NZ_CP035994.1 Lanthipeptides: EXW32_RS16150_lanthipeptide NZ_CP035994.1 Lanthipeptides: EXW32_RS16145_lanthipeptide NZ_CP035994.1 Lanthipeptides: EXW32_RS16140_lanthipeptide NZ_CP035999.1 Lanthipeptides: EXW27_RS26195_lanthipeptide NZ_CP035999.1 Lanthipeptides: EXW27_RS26190_lanthipeptide NZ_CP035999.1 Lanthipeptides: EXW27_RS26185_lanthipeptide NZ_CP035999.1 Lanthipeptides: EXW27_RS26180_lanthipeptide NZ_CP036099.1 Lanthipeptides: EXW47_RS16265_lanthipeptide NZ_CP036099.1 Lanthipeptides: EXW47_RS16260_lanthipeptide NZ_CP036099.1 Lanthipeptides: EXW47_RS16255_lanthipeptide NZ_CP036099.1 Lanthipeptides: EXW47_RS16250_lanthipeptide NZ_CP036117.1 Lanthipeptides: EXW43_RS16620_lanthipeptide NZ_CP036117.1 Lanthipeptides: EXW43_RS16615_lanthipeptide NZ_CP036117.1 Lanthipeptides: EXW43_RS16610_lanthipeptide NZ_CP036117.1 Lanthipeptides: EXW43_RS16605_lanthipeptide NZ_CP036145.1 Lanthipeptides: EXW57_RS16110_lanthipeptide NZ_CP036145.1 Lanthipeptides: EXW57_RS16105_lanthipeptide NZ_CP036145.1 Lanthipeptides: EXW57_RS16100_lanthipeptide NZ_CP036145.1 Lanthipeptides: EXW57_RS16095_lanthipeptide NZ_CP040334.1 Lanthipeptides: EUC39_RS14125_lanthipeptide NZ_CP040334.1 Lanthipeptides: EUC39_RS14120_lanthipeptide NZ_CP040334.1 Lanthipeptides: EUC39_RS14115_lanthipeptide NZ_CP045606.2 Lanthipeptides: GE376_RS18355_lanthipeptide NZ_CP045606.2 Lanthipeptides: GE376_RS18350_lanthipeptide NZ_CP045606.2 Lanthipeptides: GE376_RS18345_lanthipeptide NZ_CP047366.1 Lanthipeptides: GSN03_RS15835_lanthipeptide NZ_CP047366.1 Lanthipeptides: GSN03_RS15830_lanthipeptide NZ_CP071811.1 Lanthipeptides: EXW36_RS16415_lanthipeptide NZ_CP071811.1 Lanthipeptides: EXW36_RS16410_lanthipeptide NZ_CP071811.1 Lanthipeptides: EXW36_RS16405_lanthipeptide NZ_CP072061.1 Lanthipeptides: J5V93_RS15130_lanthipeptide NZ_CP072061.1 Lanthipeptides: J5V93_RS15125_lanthipeptide NZ_CP072061.1 Lanthipeptides: J5V93_RS15120_lanthipeptide NZ_CP084035.1 Lanthipeptides: LCF45_RS15990_lanthipeptide NZ_CP084035.1 Lanthipeptides: LCF45_RS15985_lanthipeptide NZ_CP084035.1 Lanthipeptides: LCF45_RS15980_lanthipeptide NZ_CP084035.1 Lanthipeptides: LCF45_RS15975_lanthipeptide NZ_CP093291.1 Lanthipeptides: MN093_RS25975_lanthipeptide NZ_CP093291.1 Lanthipeptides: MN093_RS25970_lanthipeptide NZ_CP093291.1 Lanthipeptides: MN093_RS25965_lanthipeptide NZ_CP093291.1 Lanthipeptides: MN093_RS25960_lanthipeptide NZ_CP093835.1 Lanthipeptides: MN034_RS15810_lanthipeptide NZ_CP093835.1 Lanthipeptides: MN034_RS15805_lanthipeptide NZ_CP093835.1 Lanthipeptides: MN034_RS15800_lanthipeptide NZ_CP093835.1 Lanthipeptides: MN034_RS15795_lanthipeptide NZ_JAIPUK010000008.1 Lanthipeptides: K9P71_RS24265_lanthipeptide NZ_JAIPUK010000008.1 Lanthipeptides: K9P71_RS24260_lanthipeptide NZ_JANCTB010000001.1 Lanthipeptides: NMG90_RS06155_lanthipeptide NZ_JANCTB010000001.1 Lanthipeptides: NMG90_RS06150_lanthipeptide NZ_JANCTB010000001.1 Lanthipeptides: NMG90_RS06145_lanthipeptide NZ_JANCTB010000001.1 Lanthipeptides: NMG90_RS06140_lanthipeptide NZ_JH792114.1 Lanthipeptides: II3_RS21535_lanthipeptide NZ_JH792114.1 Lanthipeptides: II3_RS21530_lanthipeptide NZ_JH792114.1 Lanthipeptides: II3_RS21525_lanthipeptide NZ_JH792251.1 Lanthipeptides: III_RS11095_lanthipeptide NZ_JH792251.1 Lanthipeptides: III_RS11090_lanthipeptide NZ_JH792251.1 Lanthipeptides: III_RS11085_lanthipeptide NZ_JH792251.1 Lanthipeptides: III_RS11080_lanthipeptide NZ_JH792251.1 Lanthipeptides: III_RS11075_lanthipeptide NZ_LDGT01000041.1 Lanthipeptides: ABE17_RS18900_lanthipeptide NZ_LDGT01000041.1 Lanthipeptides: ABE17_RS18895_lanthipeptide NZ_LDGT01000041.1 Lanthipeptides: ABE17_RS18890_lanthipeptide NZ_LDGT01000041.1 Lanthipeptides: ABE17_RS18885_lanthipeptide NZ_LDHL01000037.1 Lanthipeptides: ABD98_RS26430_lanthipeptide NZ_LDHL01000037.1 Lanthipeptides: ABD98_RS26425_lanthipeptide NZ_MOOL01000076.1 Lanthipeptides: BK733_RS27280_lanthipeptide NZ_MOOL01000076.1 Lanthipeptides: BK733_RS27275_lanthipeptide NZ_MOOL01000076.1 Lanthipeptides: BK733_RS27270_lanthipeptide NZ_MSTN01000016.1 Lanthipeptides: BVF97_RS28620_lanthipeptide NZ_NIUP01000011.1 Lanthipeptides: CEU84_RS08145_lanthipeptide NZ_NIUP01000011.1 Lanthipeptides: CEU84_RS08140_lanthipeptide NZ_NKAX01000026.1 Lanthipeptides: CE086_RS26165_lanthipeptide NZ_NKAX01000026.1 Lanthipeptides: CE086_RS26160_lanthipeptide NZ_NVGU01000011.1 Lanthipeptides: COL71_RS14760_lanthipeptide NZ_NVGU01000011.1 Lanthipeptides: COL71_RS14755_lanthipeptide
Lanthipeptides: YBT1518_RS19670_lanthipeptide
1
I T S I S A C T P G C G N T G S F N S F C C
22
I T S I S A C T P G C G N T G S F N S F C C
1
I T S I S A C T P G C G N T G S F N S F C C
22
95.5%
NC_022873.1:
Lanthipeptides: YBT1518_RS19675_lanthipeptide
1
I T S I S A C T P G C G N T G S F N S F C C
22
I T I S A C T P G C G N T G S F N S F C C
1
I T R I S A C T P G C G N T G S F N S F C C
22
82.6%
NZ_CP047792.1 and 1 other:
NZ_JAGSAY010000004.1 Lanthipeptides: KC186_RS06745_lanthipeptide
Lanthipeptides: E3S88_RS07345_lanthipeptide
1
I T S I S A C T P G C G N T G S F N S F C C
22
I T S S C T P G C N T G S F N S F C C
2
I T S H S L C T P G C A N T G S F N S F C C
23
with 111 more sequence matches
Only the first 10 are displayed here.
81.8%
NC_006582.1 and 6 others:
NZ_BOQQ01000001.1 Lanthipeptides: KI354_RS00530_lanthipeptide NZ_BOQS01000001.1 Lanthipeptides: KI364_RS00675_lanthipeptide NZ_CP019985.1 Lanthipeptides: BC8716_RS09795_lanthipeptide NZ_CP104963.1 Lanthipeptides: N7M99_RS07725_lanthipeptide NZ_FRBS01000002.1 Lanthipeptides: BUC05_RS08990_lanthipeptide NZ_JAODPB010000001.1 Lanthipeptides: N6H06_RS03040_lanthipeptide
Lanthipeptides: ABC_RS22115_lanthipeptide
1
I T S I S A C T P G C G N T G S F N S F C C
22
T S+S C T P G C G T G S F N S F C C
1
F T S V S F C T P G C G E T G S F N S F C C
22
81.8%
NC_014023.1 and 36 others:
NC_014023.1 Lanthipeptides: BMQ_RS27575_lanthipeptide NZ_CP018875.1 Lanthipeptides: BUW91_RS26425_lanthipeptide NZ_CP018875.1 Lanthipeptides: BUW91_RS26420_lanthipeptide NZ_CP028091.1 Lanthipeptides: C1N54_RS28075_lanthipeptide NZ_CP028091.1 Lanthipeptides: C1N54_RS28070_lanthipeptide NZ_CP028091.1 Lanthipeptides: C1N54_RS28065_lanthipeptide NZ_CP031776.1 Lanthipeptides: D0441_RS30140_lanthipeptide NZ_CP041065.1 Lanthipeptides: FJM50_RS01185_lanthipeptide NZ_CP041065.1 Lanthipeptides: FJM50_RS01180_lanthipeptide NZ_CP041065.1 Lanthipeptides: FJM50_RS01175_lanthipeptide NZ_CP048884.1 Lanthipeptides: BMG_RS27510_lanthipeptide NZ_CP058263.1 Lanthipeptides: HW576_RS26980_lanthipeptide NZ_CP058263.1 Lanthipeptides: HW576_RS26975_lanthipeptide NZ_CP058263.1 Lanthipeptides: HW576_RS26970_lanthipeptide NZ_CP085427.1 Lanthipeptides: LIT30_RS26985_lanthipeptide NZ_CP085427.1 Lanthipeptides: LIT30_RS26980_lanthipeptide NZ_CP085427.1 Lanthipeptides: LIT30_RS26975_lanthipeptide NZ_CP085432.1 Lanthipeptides: LIT34_RS27820_lanthipeptide NZ_CP085432.1 Lanthipeptides: LIT34_RS27815_lanthipeptide NZ_CP085432.1 Lanthipeptides: LIT34_RS27810_lanthipeptide NZ_JACJHT010000009.1 Lanthipeptides: HNP21_RS25635_lanthipeptide NZ_JACJHT010000009.1 Lanthipeptides: HNP21_RS25630_lanthipeptide NZ_JACJHT010000009.1 Lanthipeptides: HNP21_RS25625_lanthipeptide NZ_JAHHYI010000015.1 Lanthipeptides: KM925_RS26245_lanthipeptide NZ_JANIOE010000010.1 Lanthipeptides: NQ109_RS28075_lanthipeptide NZ_JANIOE010000010.1 Lanthipeptides: NQ109_RS28070_lanthipeptide NZ_JANIOE010000010.1 Lanthipeptides: NQ109_RS28065_lanthipeptide NZ_NKAQ01000005.1 Lanthipeptides: CE057_RS19640_lanthipeptide NZ_NKAQ01000005.1 Lanthipeptides: CE057_RS19635_lanthipeptide NZ_NTZG01000054.1 Lanthipeptides: CN510_RS18265_lanthipeptide NZ_NUIN01000020.1 Lanthipeptides: CN973_RS26930_lanthipeptide NZ_NUOI01000090.1 Lanthipeptides: COE08_RS30285_lanthipeptide NZ_NUOI01000090.1 Lanthipeptides: COE08_RS30280_lanthipeptide NZ_NUOQ01000009.1 Lanthipeptides: COE31_RS05925_lanthipeptide NZ_NUXL01000007.1 Lanthipeptides: COJ36_RS20885_lanthipeptide NZ_NUZS01000089.1 Lanthipeptides: COJ90_RS28785_lanthipeptide
Lanthipeptides: BMQ_RS27580_lanthipeptide
1
I T S I S A C T P G C G N T G S F N S F C C
22
I T S+S C T P G C G+T G S+N S F C C
1
I T S V S L C T P G C G D T G S W N S F C C
22
81.8%
NZ_FNNQ01000006.1 and 2 others:
NZ_FNNQ01000006.1 Lanthipeptides: BLV90_RS07685_lanthipeptide NZ_FNNQ01000006.1 Lanthipeptides: BLV90_RS07680_lanthipeptide
Lanthipeptides: BLV90_RS07690_lanthipeptide
1
I T S I S A C T P G C G N T G S F N S F C C
22
I T S+S C T P G C G T G S F N S+C C
1
I T S V S L C T P G C G E T G S F N S Y C C
22
81.8%
NZ_FPAA01000016.1 and 3 others:
NZ_FPAA01000016.1 Lanthipeptides: CHX35_RS15995_lanthipeptide NZ_FPAA01000016.1 Lanthipeptides: CHX35_RS15990_lanthipeptide NZ_FPAA01000016.1 Lanthipeptides: CHX35_RS15985_lanthipeptide
Lanthipeptides: CHX35_RS16000_lanthipeptide
1
I T S I S A C T P G C G N T G S F N S F C C
22
I T S+S C T P G C G+T G S F N S+C C
1
I T S V S L C T P G C G D T G S F N S Y C C
22
81.8%
NZ_LELK01000004.1:
Lanthipeptides: AB986_RS12540_lanthipeptide
1
I T S I S A C T P G C G N T G S F N S F C C
22
I T S S C T P G C G T G S F N S+C C
1
I T S Y S F C T P G C G E T G S F N S Y C C
22
78.3%
NC_003923.1 and 9 others:
NC_009641.1 Lanthipeptides: NWMN_RS09635_lanthipeptide NZ_CP023076.1 Lanthipeptides: CJ017_RS08945_lanthipeptide NZ_CP054876.1 Lanthipeptides: HUW54_RS09150_lanthipeptide NZ_CP077098.1 Lanthipeptides: KSF82_RS09475_lanthipeptide NZ_CP092781.1 Lanthipeptides: ML436_RS08940_lanthipeptide NZ_CP102959.1 Lanthipeptides: NW979_RS08780_lanthipeptide NZ_CP102962.1 Lanthipeptides: NW971_RS09555_lanthipeptide NZ_LR133917.1 Lanthipeptides: ELZ45_RS09155_lanthipeptide NZ_LS483317.1 Lanthipeptides: DQL75_RS09700_lanthipeptide
Lanthipeptides: MW_RS09420_lanthipeptide
1
I T S I S A C T P G C G N T G S F N S F C C
22
I T S S C T P G C T G S F N S F C C
2
I T S H S L C T P G C A K T G S F N S F C C
23
78.3%
NZ_LR134304.1:
Lanthipeptides: EL116_RS09245_lanthipeptide
1
I T S I S A C T P G C G N T G S F N S F C C
22
I T S+ C T P G C G T G S F N S F C C
2
I T S V I G C T P G C G K T G S F N S F C C
23
77.3%
NZ_AP019791.1:
Lanthipeptides: RxyAA322_RS06460_lanthipeptide
1
I T S I S A C T P G C G N T G S F N S F C C
22
I T S S C T P G C T G S F N S+C C
1
I T S Y S L C T P G C A K T G S F N S Y C C
22
72.7%
NZ_QGTF01000010.1:
Lanthipeptides: BDW27_RS18560_lanthipeptide
1
I T S I S A C T P G C G N T G S F N S F C C
22
+T S+S C T P G C N G+F N S F C C
1
V T S V S V C T P G C E N-G T F N S F C C
21
70.8%
NZ_VKCY01000012.1:
Lanthipeptides: FNK43_RS09020_lanthipeptide
1
I T S I S A C T P G C G N T G S F N S F C C
22
I T S S C T P G C T G S F N S+C C
3
I T S F S L C T P G C A K T G S F N S Y C C
24

#### MIBiG 4.0 matches for WR47_RS18165

35.3%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
1
I T S I S A C T P G C G N T G S F
17
I T S I S C T P G C T G+
1
I T S I S L C T P G C-K T G A L
16

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.05 out of 20.97
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.12 out of 20.97
Confidence: strong
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.81 out of 25.88
Confidence: medium
Additional weak hits (2):
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.71 out of 30.97
Confidence: weak
Lanthipeptides
RREFinder
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

WR47_RS18165 - Class I
  Cleavage pHMM score: 11.60
  RODEO score: 33
  Monoisotopic mass: 1996.9 Da
  Molecular weight: 1998.3 Da
  Number of bridges: 3
  Additional modifications: AviCys
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2016.3 Da N = 1
    2034.3 Da N = 2
    2052.3 Da N = 3
WR47_RS18170 - Class I
  Cleavage pHMM score: 11.60
  RODEO score: 33
  Monoisotopic mass: 1996.9 Da
  Molecular weight: 1998.3 Da
  Number of bridges: 3
  Additional modifications: AviCys
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2016.3 Da N = 1
    2034.3 Da N = 2
    2052.3 Da N = 3
WR47_RS18175 - Class I
  Cleavage pHMM score: 11.60
  RODEO score: 33
  Monoisotopic mass: 1996.9 Da
  Molecular weight: 1998.3 Da
  Number of bridges: 3
  Additional modifications: AviCys
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2016.3 Da N = 1
    2034.3 Da N = 2
    2052.3 Da N = 3
WR47_RS18180 - Class I
  Cleavage pHMM score: 11.60
  RODEO score: 33
  Monoisotopic mass: 1996.9 Da
  Molecular weight: 1998.3 Da
  Number of bridges: 3
  Additional modifications: AviCys
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2016.3 Da N = 1
    2034.3 Da N = 2
    2052.3 Da N = 3

RRE predictions
RREfinder results sidepanel.

lanthipeptide-class-i protocluster (3691415...3717859)
WR47_RS18160
  RRE type: Lanthipeptide_LanB_RRE
  Location: 162 - 259
  Score: 82.1

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
PsrA | Oleic acid responsive regulator

NZ_CP011151.1 - Region 13 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,262,648 - 4,283,538 nt. (total: 20,891 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: carboxylase
WR47_RS21125: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase
WR47_RS21090: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

WR47_RS21095: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002219.2 |  | 0.39 | terpene | (-)-(R)-nephthenol | Stereum hirsutum FP-91666 SS1
BGC0000665.5 |  | 0.38 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002219.2 |  | 0.39 | terpene | (-)-(R)-nephthenol | Stereum hirsutum FP-91666 SS1
BGC0000665.5 |  | 0.38 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
WR47_RS21095: PT_FPPS_like
Domain 1 (32 - 295): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  IPP, DMAPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.49 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.66 out of 26.06
Confidence: medium
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.32 out of 25.88
Confidence: medium
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.28 out of 26.33
Confidence: medium
Additional weak hits (2):
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.73 out of 30.98
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.40 out of 33.14
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes
PsrA | Oleic acid responsive regulator

NZ_CP011152.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 41,817 - 98,035 nt. (total: 56,219 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
WR47_RS27755: nucleotide sugar dehydrogenase

smcogs
  SMCOG1152: nucleotide sugar dehydrogenase

Transferases: PPTase glycosyltransferase transferase
WR47_RS27750: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs
  SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

WR47_RS27765: glycosyl transferase group 1

smcogs
  SMCOG1045: glycosyl transferase group 1

WR47_RS27785: glycosyl transferase group 1

smcogs
  SMCOG1045: glycosyl transferase group 1

WR47_RS32740: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: deaminase esterase
WR47_RS27820: ornithine cyclodeaminase

smcogs
  SMCOG1158: ornithine cyclodeaminase

WR47_RS27840: thioesterase

smcogs
  SMCOG1004: thioesterase

Lyases: dehydratase
WR47_RS27760: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: ligase synthase
WR47_RS27825: cysteine synthase

smcogs
  SMCOG1081: cysteine synthase

WR47_RS27845: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

WR47_RS27850: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

WR47_RS27855: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.77 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001833.4 |  | 0.77 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  | 0.76 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  | 0.75 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002075.3 |  | 0.74 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0001825.4 |  | 0.74 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0002286.3 |  | 0.74 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.74 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001758.4 |  | 0.73 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001166.5 |  | 0.72 | NRPS | HC-toxin | Alternaria jesenskae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.77 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001833.4 |  | 0.77 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  | 0.76 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  | 0.75 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002075.3 |  | 0.74 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0001825.4 |  | 0.74 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0002286.3 |  | 0.74 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.74 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001758.4 |  | 0.73 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001166.5 |  | 0.72 | NRPS | HC-toxin | Alternaria jesenskae

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.71 out of 29.38
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.10 out of 27.55
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.33 out of 18.16
Confidence: strong
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.49 out of 24.78
Confidence: medium
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 26.57 out of 33.14
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.73 out of 28.19
Confidence: medium
Additional weak hits (4):
DosR
Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 20.52 out of 29.51
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 23.11 out of 29.65
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 16.52 out of 30.12
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 41816 - 98035:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (NH2 - Thr - X) + (Asn) + (Asn)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
WR47_RS27845: Asn
Search NORINE for peptide: strict or relaxed
AMP-binding (507..909): Asn
nrpys: Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWCSFDLTITGSKLVVGGEINEYGPTEAVVGCTN
  Nearest Stachelhaus code(s):
    Asn DLTKVGEVGK (76% 8Å match)
  Stachelhaus code match:
    100% (strong)

WR47_RS27850: Asn
Search NORINE for peptide: strict or relaxed
AMP-binding (504..906): Asn
nrpys: Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWCSFDLTITGSKLVVGGEINEYGPTEAVVGCTN
  Nearest Stachelhaus code(s):
    Asn DLTKVGEVGK (76% 8Å match)
  Stachelhaus code match:
    100% (strong)

WR47_RS27855: NH2 - Thr - X
Search NORINE for peptide: strict or relaxed
CAL_domain (168..484): NH2
minowa: NH2

Prediction, score:
  NH2: 129.0
  Acetyl-CoA: 45.2
  AHBA: 12.8
  fatty_acid: 1.5
  shikimic_acid: 0.0

AMP-binding (1174..1580): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LAAHFDFSVWEGNQIFGGEINMYGITETTVHVTY
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (2243..2651): X
nrpys: Dpr

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    HAKAFDVSVWQSETVLNGEINACGATESSDDVNH
  Nearest Stachelhaus code(s):
    Dpr DVWEMNADDK (68% 8Å match)
  Stachelhaus code match:
    90% (moderate)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
FuR variant 1 | Ferric Uptake Regulator
GnfM | Regulator of nitrogen-fixation genes
LexA variant 2 | Repressor of DNA damage response
ZuR variant 1 | Zinc-responsive repressor
ZuR variant 2 | Zinc-responsive repressor

NZ_CP011152.1 - Region 2 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 255,137 - 267,356 nt. (total: 12,220 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001862.4 |  | 0.55 | ribosomal | pallidocin | Aeribacillus pallidus
BGC0002674.2 |  | 0.52 | ribosomal | enterocin F4-9 | Enterococcus faecalis
BGC0000558.5 |  | 0.49 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000484.5 |  | 0.48 | ribosomal | glycocin F | Lactobacillus plantarum
BGC0002586.2 |  | 0.47 | ribosomal | ASM1 | Lactiplantibacillus plantarum
BGC0001864.3 |  | 0.47 | ribosomal | listeriocytocin | Listeria monocytogenes SLCC2540
BGC0001861.4 |  | 0.46 | ribosomal | bacillicin BAG2O | Bacillus cereus BAG2O-1
BGC0001863.4 |  | 0.46 | ribosomal, terpene | bacillicn CER074 | Bacillus mycoides
BGC0000590.5 |  | 0.46 | ribosomal | microcin N | Escherichia coli
BGC0000589.5 |  | 0.46 | ribosomal | microcin M | Escherichia coli Nissle 1917

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001862.4 |  | 0.55 | ribosomal | pallidocin | Aeribacillus pallidus
BGC0002674.2 |  | 0.52 | ribosomal | enterocin F4-9 | Enterococcus faecalis
BGC0000558.5 |  | 0.49 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000484.5 |  | 0.48 | ribosomal | glycocin F | Lactobacillus plantarum
BGC0002586.2 |  | 0.47 | ribosomal | ASM1 | Lactiplantibacillus plantarum
BGC0001864.3 |  | 0.47 | ribosomal | listeriocytocin | Listeria monocytogenes SLCC2540
BGC0001861.4 |  | 0.46 | ribosomal | bacillicin BAG2O | Bacillus cereus BAG2O-1
BGC0001863.4 |  | 0.46 | ribosomal, terpene | bacillicn CER074 | Bacillus mycoides
BGC0000590.5 |  | 0.46 | ribosomal | microcin N | Escherichia coli
BGC0000589.5 |  | 0.46 | ribosomal | microcin M | Escherichia coli Nissle 1917

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.77 out of 20.97
Confidence: medium
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A

NZ_CP011152.1 - Region 3 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 278,262 - 307,122 nt. (total: 28,861 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: protease
WR47_RS28800: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase
WR47_RS28805: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

WR47_RS28840: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000517.4 |  | 0.60 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000504.5 |  | 0.55 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000525.5 |  | 0.54 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000554.4 |  | 0.54 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000516.4 |  | 0.54 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000623.3 |  | 0.54 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0001229.4 |  | 0.52 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0001210.5 |  | 0.50 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000520.5 |  | 0.49 | ribosomal | lacticin 3147 A1, lacticin 3147 A2 | Lactococcus lactis
BGC0000500.5 |  | 0.49 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000517.4 |  | 0.60 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000504.5 |  | 0.55 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000525.5 |  | 0.54 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000554.4 |  | 0.54 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000516.4 |  | 0.54 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000623.3 |  | 0.54 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0001229.4 |  | 0.52 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0001210.5 |  | 0.50 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000520.5 |  | 0.49 | ribosomal | lacticin 3147 A1, lacticin 3147 A2 | Lactococcus lactis
BGC0000500.5 |  | 0.49 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for WR47_RS28805

WR47_RS28810
Leader:
MKNNSIMRFWKDPLYRMDLSSDERGNMPGS
Core:
P V G D S L E E I Q G N E L L N A V G A G D V Q A N T S T V Q I L T P R T P I I S N T L G N K G H A C T I T K E C Q N M C N
Core with dehydrations:
P V G D Dha L E E I Q G N E L L N A V G A G D V Q A N Dhb Dha Dhb V Q I L Dhb P R Dhb P I I Dha N Dhb L G N K G H A Cys Dhb I Dhb K E Cys Q N M Cys N

#### antiSMASH-DB 4.0 matches for WR47_RS28810

100.0%
NZ_CP011152.1 and 1 other:
NZ_CP011152.1 Lanthipeptides: WR47_RS28810_lanthipeptide
Lanthipeptides: WR47_RS28810_lanthipeptide
1
P V G D S L E E I Q G N E L L N A V G A G D V Q A N T S T V Q I L T P R T P I I S N T L G N K G H A C T I T K E C Q N M C N
62
P V G D S L E E I Q G N E L L N A V G A G D V Q A N T S T V Q I L T P R T P I I S N T L G N K G H A C T I T K E C Q N M C N
1
P V G D S L E E I Q G N E L L N A V G A G D V Q A N T S T V Q I L T P R T P I I S N T L G N K G H A C T I T K E C Q N M C N
62
84.4%
NZ_CP011152.1 and 3 others:
NZ_CP011152.1 Lanthipeptides: WR47_RS28815_lanthipeptide NZ_CP011152.1 Lanthipeptides: WR47_RS28820_lanthipeptide NZ_CP011152.1 Lanthipeptides: WR47_RS28815_lanthipeptide
Lanthipeptides: WR47_RS28820_lanthipeptide
1
P V G D S L E E I Q G N E L L N A V G A G D V Q A N T S T V Q I--L T P R T P I I S N T L G N K G H A C T I T K E C Q N M C N
62
P V G D S L E E I Q G N E L L N A V G A G D V Q A N T+T+ + L T ++P I S N T L G N K G H A C T I T K E C Q N M C N
1
P V G D S L E E I Q G N E L L N A V G A G D V Q A N T N T I V V T Q L T A K S P Y I S N T L G N K G H A C T I T K E C Q N M C N
64
30.6%
NZ_CP009288.1 and 3 others:
NZ_CP009288.1 Lanthipeptides: PDUR_RS25150_lanthipeptide NZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptide NZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptide
Lanthipeptides: PDUR_RS25150_lanthipeptide
33
L T P R T P I-I S N T L G N K G H A C T I T K E C Q N M C N
62
L T T I I S T L G N G C T T K E C C N
6
L T T S T S I L I S M T L G N N G W V C T A T K E C M P S C N
36
with 112 more sequence matches
Only the first 10 are displayed here.
29.0%
NZ_JALGRP010000007.1 and 1 other:
NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide
Lanthipeptides: MT347_RS12955_lanthipeptide
24
Q A N T S T V Q I L T P R T P I I S N T L G N K G H A C T I T K E C Q N M C N
62
Q T+T+ L T +S G N G C T T E C Q N C N
3
Q G W T T T I T S L T C Y G--V S W V A G N N G Q V C T A T V E C Q N N C N
39
27.4%
NZ_BMFU01000012.1 and 5 others:
NZ_BMFU01000012.1 Lanthipeptides: IEW26_RS25375_lanthipeptide NZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23855_lanthipeptide NZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23855_lanthipeptide NZ_VDYW01000008.1 Lanthipeptides: FS579_RS24445_lanthipeptide NZ_VDYW01000008.1 Lanthipeptides: FS579_RS24445_lanthipeptide
Lanthipeptides: IEW26_RS25375_lanthipeptide
21
G D V Q A N T S T V Q I L T P R T P I I S N T L G N K G H A C T I T K E C Q N M C N
62
G Q V I + S +G N G H C T+T E C Q C N
1
G A A Q P E W V E V I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C N
42
27.4%
NZ_CP009280.1 and 1 other:
NZ_CP009280.1 Lanthipeptides: P40081_RS01820_lanthipeptide
Lanthipeptides: P40081_RS01820_lanthipeptide
33
L T P R T P I-I S N T L G N K G H A C T I T K E C Q N M C N
62
L T T I I S L G N G C T +K E C C N
6
L T T S T S I F I S R G L G N D G W V C T W S K E C M P S C N
36
27.4%
NZ_CP084530.1 and 1 other:
NZ_CP084530.1 Lanthipeptides: LDO05_RS02075_lanthipeptide
Lanthipeptides: LDO05_RS02075_lanthipeptide
34
T P R T P I I S N T L G N K G H A C T I T K E C Q N M C N
62
T T +S N L G N G C T+T K E C Q C N
2
T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
30
27.4%
NZ_JACHKG010000014.1 and 1 other:
NZ_JACHKG010000014.1 Lanthipeptides: allorf_027480_027638_lanthipeptide
Lanthipeptides: allorf_027480_027638_lanthipeptide
21
G D V Q A N T S T V Q I L T P R T P I I S N T L G N K G H A C T I T K E C Q N M C N
62
G Q + V I + S +G N G H C T+T E C Q C N
1
G A A Q P Q W A E V I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C N
42
27.4%
NZ_LT985747.1 and 1 other:
NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide
Lanthipeptides: C8268_RS00165_lanthipeptide
34
T P R T P I I S N T L G N K G H A C T I T K E C Q N M C N
62
T T +S+ L G N K G C T+T K E C Q C N
2
T T N T F T L S D Y L G N K G G W C T L T K E C Q R S C N
30
25.8%
NZ_BJTV01000004.1 and 1 other:
NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS10200_lanthipeptide
Lanthipeptides: TNCT1_RS10200_lanthipeptide
34
T P R T P I I S N T L G N K G H A C T I T K E C Q N M C N
62
T T +S+ L G N G C T+T K E C Q C N
2
T T N T F S L S D A L G N H G G W C T L T K E C Q A N C N
30
25.8%
NZ_BNBV01000031.1 and 1 other:
NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22995_lanthipeptide
Lanthipeptides: IE286_RS22995_lanthipeptide
34
T P R T P I I S N T L G N K G H A C T I T K E C Q N M C N
62
T T +S+ L G N G C T+T K E C Q C N
2
T T N T F S L S D A L G N S G G W C T L T K E C Q P N C N
30
25.8%
NZ_CM000756.1 and 7 others:
NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS34475_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide
Lanthipeptides: BTHUR0011_RS34475_lanthipeptide
34
T P R T P I I S N T L G N K G H A C T I T K E C Q N M C
61
T + I I S T G N K G C T T E C N C
9
T S T S I I I S E T F G N K G K V C T Y T V E C V N N C
36
25.8%
NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide
Lanthipeptides: CWT12_RS00385_lanthipeptide
38
P I I S N T L G N K G H A C T I T K E C Q N M C N
62
P +S L G N G+ C T+T K E C Q M C N
3
P W L S R K L G N T G Y V C T L T K E C Q R M C N
27

#### MIBiG 4.0 matches for WR47_RS28810

27.4%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
34
T P R T P I I S N T L G N K G H A C T I T K E C Q N M C N
62
T T +S N L G N G C T+T K E C Q C N
2
T T N T F S L S N A L G N N G G W C T L T K E C Q P N C N
30
22.6%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
40
I S N T L G N K G H A C T I T K E C Q N M C N
62
I S L G N K G C T+T E C C N
6
I S C R L G N K G A Y C T L T V E C M P S C N
28
12.9%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
51
C T I T K E C Q N M C N
62
C T++K E C Q C N
28
C T L S K E C Q P N C N
39
with 1 more sequence matches
8.1%
BGC0000582.4 (ADR72962.1):
Linaridin: cypemycin
34
T P R T P I I S N T L G N K G H A C T I
53
T P T P ++ + C +
2
T P A T P T V A Q F V I Q G S T I C L V
21
WR47_RS28815
Leader:
MKNNSIMRFWKDPLYRMDLSSDERGNMPGS
WR47_RS28820
Leader:
MKNNSIMRFWKDPLYRMDLSSDERGNMPGS
Shared core:
P V G D S L E E I Q G N E L L N A V G A G D V Q A N T N T I V V T Q L T A K S P Y I S N T L G N K G H A C T I T K E C Q N M C N
Core with dehydrations:
P V G D Dha L E E I Q G N E L L N A V G A G D V Q A N Dhb N Dhb I V V Dhb Q L Dhb A K Dha P Y I Dha N Dhb L G N K G H A Cys Dhb I Dhb K E Cys Q N M Cys N

#### antiSMASH-DB 4.0 matches for WR47_RS28815

100.0%
NZ_CP011152.1 and 3 others:
NZ_CP011152.1 Lanthipeptides: WR47_RS28815_lanthipeptide NZ_CP011152.1 Lanthipeptides: WR47_RS28820_lanthipeptide NZ_CP011152.1 Lanthipeptides: WR47_RS28815_lanthipeptide
Lanthipeptides: WR47_RS28820_lanthipeptide
1
P V G D S L E E I Q G N E L L N A V G A G D V Q A N T N T I V V T Q L T A K S P Y I S N T L G N K G H A C T I T K E C Q N M C N
64
P V G D S L E E I Q G N E L L N A V G A G D V Q A N T N T I V V T Q L T A K S P Y I S N T L G N K G H A C T I T K E C Q N M C N
1
P V G D S L E E I Q G N E L L N A V G A G D V Q A N T N T I V V T Q L T A K S P Y I S N T L G N K G H A C T I T K E C Q N M C N
64
84.4%
NZ_CP011152.1 and 1 other:
NZ_CP011152.1 Lanthipeptides: WR47_RS28810_lanthipeptide
Lanthipeptides: WR47_RS28810_lanthipeptide
1
P V G D S L E E I Q G N E L L N A V G A G D V Q A N T N T I V V T Q L T A K S P Y I S N T L G N K G H A C T I T K E C Q N M C N
64
P V G D S L E E I Q G N E L L N A V G A G D V Q A N T+T+ + L T ++P I S N T L G N K G H A C T I T K E C Q N M C N
1
P V G D S L E E I Q G N E L L N A V G A G D V Q A N T S T V Q I--L T P R T P I I S N T L G N K G H A C T I T K E C Q N M C N
62
28.1%
NZ_CP009280.1 and 1 other:
NZ_CP009280.1 Lanthipeptides: P40081_RS01820_lanthipeptide
Lanthipeptides: P40081_RS01820_lanthipeptide
26
N T N T I V V T Q L T A K S P Y I S N T L G N K G H A C T I T K E C Q N M C N
64
+T N T+ T+ S +I S L G N G C T +K E C C N
2
D T N T L T----T S T S I F I S R G L G N D G W V C T W S K E C M P S C N
36
with 111 more sequence matches
Only the first 10 are displayed here.
28.1%
NZ_CP009288.1 and 3 others:
NZ_CP009288.1 Lanthipeptides: PDUR_RS25150_lanthipeptide NZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptide NZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptide
Lanthipeptides: PDUR_RS25150_lanthipeptide
33
T Q L T A K S P Y I S N T L G N K G H A C T I T K E C Q N M C N
64
T T+ S I S T L G N G C T T K E C C N
5
T L T T S T S I L I S M T L G N N G W V C T A T K E C M P S C N
36
28.1%
NZ_JALIRS010000003.1 and 3 others:
NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07255_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide
Lanthipeptides: MOK21_RS07255_lanthipeptide
29
T I V V T Q L T A K S P Y I S N T L G N K G H A C T I T K E C Q N M C N
64
T I+ + A + Y I L G N G H C T+T E C Q C N
8
T I L T S L A C A A A S Y I---L G N P G H V C T L T V E C Q K K C N
40
26.6%
NZ_BMFU01000012.1 and 5 others:
NZ_BMFU01000012.1 Lanthipeptides: IEW26_RS25375_lanthipeptide NZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23855_lanthipeptide NZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23855_lanthipeptide NZ_VDYW01000008.1 Lanthipeptides: FS579_RS24445_lanthipeptide NZ_VDYW01000008.1 Lanthipeptides: FS579_RS24445_lanthipeptide
Lanthipeptides: IEW26_RS25375_lanthipeptide
21
G D V Q A N T N T I V V T Q L T A K S P Y I S N T L G N K G H A C T I T K E C Q N M C N
64
G Q +++T L + S +G N G H C T+T E C Q C N
1
G A A Q P E W V E V I I T S L A C A A A--S Y F M G N P G H V C T L T V E C Q K S C N
42
26.6%
NZ_CM000756.1 and 7 others:
NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS34475_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide
Lanthipeptides: BTHUR0011_RS34475_lanthipeptide
33
T Q L T A K S P Y I S N T L G N K G H A C T I T K E C Q N M C
63
T T+ S I S T G N K G C T T E C N C
6
T T A T S T S I I I S E T F G N K G K V C T Y T V E C V N N C
36
26.6%
NZ_CP017953.1 and 27 others:
NZ_CP017953.1 Lanthipeptides: BAMY_RS16400_lanthipeptide NZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptide NZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptide NZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptide NZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptide NZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptide NZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptide NZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptide NZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptide NZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptide NZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptide NZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptide NZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptide NZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptide NZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptide NZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptide NZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptide NZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptide NZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptide NZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptide NZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptide NZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptide NZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptide NZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptide NZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptide
Lanthipeptides: BAMY_RS16400_lanthipeptide
28
N T I V V T Q L T A K S P Y I S N T L G N K G H A C T I T K E C Q N M C
63
N T T + +S L G N K G C T T K E C Q C
2
N T W N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
37
26.6%
NZ_JACHKG010000014.1 and 1 other:
NZ_JACHKG010000014.1 Lanthipeptides: allorf_027480_027638_lanthipeptide
Lanthipeptides: allorf_027480_027638_lanthipeptide
21
G D V Q A N T N T I V V T Q L T A K S P Y I S N T L G N K G H A C T I T K E C Q N M C N
64
G Q +++T L + S +G N G H C T+T E C Q C N
1
G A A Q P Q W A E V I I T S L A C A A A--S Y F M G N P G H V C T L T V E C Q K S C N
42
26.6%
NZ_JALGRP010000007.1 and 1 other:
NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide
Lanthipeptides: MT347_RS12955_lanthipeptide
29
T I V V T Q L T A K S P Y I S N T L G N K G H A C T I T K E C Q N M C N
64
T +T L T +S G N G C T T E C Q N C N
6
T T T I T S L T C Y G--V S W V A G N N G Q V C T A T V E C Q N N C N
39
25.0%
NZ_BMRY01000003.1 and 24 others:
NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptide NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptide NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptide NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptide NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide
Lanthipeptides: IE140_RS12370_lanthipeptide
29
T I V V T Q L T A K S P Y I S N T L G N K G H A C T I T K E C Q N M C
63
T I V + + Y+ L G N G+ C T T E C Q N C
6
T I V S S L S C Y G A S Y V---L G N N G N F C T A T A E C Q N N C
37
25.0%
NZ_CKMQ01000043.1 and 10 others:
NZ_CKMQ01000043.1 Lanthipeptides: AE832_RS11585_lanthipeptide NZ_CKMR01000002.1 Lanthipeptides: AD782_RS11690_lanthipeptide NZ_CKMR01000002.1 Lanthipeptides: AD782_RS11690_lanthipeptide NZ_FIXU01000003.1 Lanthipeptides: A1M11_RS11670_lanthipeptide NZ_FIXU01000003.1 Lanthipeptides: A1M11_RS11670_lanthipeptide NZ_LR216041.1 Lanthipeptides: E0F00_RS05465_lanthipeptide NZ_LR216046.1 Lanthipeptides: E0E82_RS05980_lanthipeptide NZ_LR216046.1 Lanthipeptides: E0E82_RS05980_lanthipeptide NZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00170_lanthipeptide NZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00170_lanthipeptide
Lanthipeptides: AE832_RS11585_lanthipeptide
37
A K S P Y I S N T L G N K G H A C T I T K E C Q N M C N
64
A+ +I S L G N K G C T T E C Q N C
3
A Q L S F I S E A L G N K G A V C T G T I E C Q N N C R
30
25.0%
NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide
Lanthipeptides: CWT12_RS00385_lanthipeptide
40
P Y I S N T L G N K G H A C T I T K E C Q N M C N
64
P++S L G N G+ C T+T K E C Q M C N
3
P W L S R K L G N T G Y V C T L T K E C Q R M C N
27

#### MIBiG 4.0 matches for WR47_RS28815

23.4%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
42
I S N T L G N K G H A C T I T K E C Q N M C N
64
+S N L G N G C T+T K E C Q C N
8
L S N A L G N N G G W C T L T K E C Q P N C N
30
21.9%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
42
I S N T L G N K G H A C T I T K E C Q N M C N
64
I S L G N K G C T+T E C C N
6
I S C R L G N K G A Y C T L T V E C M P S C N
28
12.5%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
53
C T I T K E C Q N M C N
64
C T++K E C Q C N
28
C T L S K E C Q P N C N
39
WR47_RS28825
Leader:
MSKNEVKSLRDPKMRTEDFNNPVGIVNEQELKQIVGA
Core:
G D I T P Q T T D A L S A V I V S V L P T L K C S S Q C R T D L
Core with dehydrations:
G D I Dhb P Q Dhb Dhb D A L Dha A V I V Dha V L P Dhb L K Cys Dha Dha Q Cys R Dhb D L

#### antiSMASH-DB 4.0 matches for WR47_RS28825

100.0%
NZ_CP011152.1 and 1 other:
NZ_CP011152.1 Lanthipeptides: WR47_RS28825_lanthipeptide
Lanthipeptides: WR47_RS28825_lanthipeptide
1
G D I T P Q T T D A L S A V I V S V L P T L K C S S Q C R T D L
32
G D I T P Q T T D A L S A V I V S V L P T L K C S S Q C R T D L
1
G D I T P Q T T D A L S A V I V S V L P T L K C S S Q C R T D L
32
60.0%
NZ_CP011152.1 and 3 others:
NZ_CP011152.1 Lanthipeptides: WR47_RS28830_lanthipeptide NZ_CP011152.1 Lanthipeptides: WR47_RS28835_lanthipeptide NZ_CP011152.1 Lanthipeptides: WR47_RS28830_lanthipeptide
Lanthipeptides: WR47_RS28835_lanthipeptide
1
G D I T P Q T T D--------A L S A V I V S V L P T L K C S S Q C R T D L
32
G D+T P Q T A A V I +V L P T L K C S S+C R T D L
1
G D V T P Q A T P T V T I L A T A A G G A V I S A V L P T L K C S S K C R T D L
40
46.9%
NZ_CP013862.1 and 1 other:
NZ_CP013862.1 Lanthipeptides: AOX59_RS09365_lanthipeptide
Lanthipeptides: AOX59_RS09365_lanthipeptide
1
G D I T P Q T T D A L S A V I V S V----L P T L K C S S Q C
28
G D+ P Q T T + A ++V P T K C+S Q C
1
G D V D P Q T T P S S V A C G I A V S A L F C P T T K C T S Q C
32
with 88 more sequence matches
Only the first 10 are displayed here.
43.8%
NC_018499.1 and 5 others:
NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27845_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide
Lanthipeptides: BCK_RS27845_lanthipeptide
1
G D I T P Q T T D A---L S A V I V S V L P T L K C S S Q C
28
G D+ P+T T A + A V + + P T K C+S+C
1
G D V N P E T T P A T P T I V A V S L G I C P T T K C T S K C
31
42.9%
NZ_CM000721.1 and 9 others:
NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide
Lanthipeptides: BCERE0010_RS29355_lanthipeptide
1
G D I T P Q T T D A L S-------A V I V S V L P T L K C S S Q C
28
G D+ P+T T A A V S+ P T K C+S+C
1
G D V N P E T T P A T P T I I G A T I A V T A S L C P T T K C T S R C
35
40.6%
NZ_CP036019.1 and 1 other:
NZ_CP036019.1 Lanthipeptides: EXW52_RS27205_lanthipeptide
Lanthipeptides: EXW52_RS27205_lanthipeptide
1
G D I T P Q T T D A L S A V I V S V----L P T L K C S S Q C
28
G D++P+T T A ++V++ P T K C+S+C
1
G D V S P E T T P A T P T I V V A I S V G L C P T T K C T S K C
32
40.6%
NZ_MLKL01000042.1:
Lanthipeptides: BKK45_RS27405_lanthipeptide
1
G D I T P Q T T D A---L S A V I V S V L P T L K C S S Q C
28
G D+ P+T T A + A V V + P T C+ C
1
G D V N P E T T P A T P T I V A V S V K L C P T G V C T K S C
31
40.6%
NZ_NUML01000015.1:
Lanthipeptides: COD66_RS20140_lanthipeptide
1
G D I T P Q T T D A L S A V I V S V----L P T L K C S S Q C
28
G D++P+T T A ++V + P T K C+S+C
1
G D V S P E T T P A T P T I V V G I S V G L C P T T K C T S K C
32
40.0%
NZ_CP015591.1 and 15 others:
NZ_CP078085.1 Lanthipeptides: KU891_RS29355_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29350_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29345_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29340_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29335_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptide
Lanthipeptides: A7A70_RS27550_lanthipeptide
1
G D I T P Q T T D A L S A V I-------V S V L P T L K C S S Q C
28
G D+ P+T T A ++ V S+ P T K C+S+C
1
G D V N P E T T P A T P T I V E A T I A A T V S I C P T T K C T S R C
35
38.5%
NZ_CP009288.1 and 3 others:
NZ_CP009288.1 Lanthipeptides: PDUR_RS29295_lanthipeptide NZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptide NZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptide
Lanthipeptides: PDUR_RS29295_lanthipeptide
1
G D I T P Q T T----------D A L S A V I V S V L P T L K C S S Q C
28
G D+ P+T T A V S+ P T K C+S Q C
2
G D V N P E T T I L T T S S W T C I T A G V T V S A S L C P T T K C T S Q C
39
37.5%
NZ_CP036019.1 and 7 others:
NZ_CP036019.1 Lanthipeptides: EXW52_RS27180_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27175_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27170_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27190_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27180_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27175_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27170_lanthipeptide
Lanthipeptides: EXW52_RS27190_lanthipeptide
1
G D I T P Q T T D A L S A V I V S V----L P T L K C S S Q C
28
G D++P+T T A ++V++ P T +C+S+C
1
G D V S P E T T P A T P T I V V A I S V G L C P T N R C T S K C
32
37.5%
NZ_JACSMH010000008.1 and 2 others:
NZ_JACSMX010000006.1 Lanthipeptides: KNQ03_RS15615_lanthipeptide NZ_JACSMZ010000005.1 Lanthipeptides: KNQ06_RS16025_lanthipeptide
Lanthipeptides: KNP89_RS14470_lanthipeptide
1
G D I T P Q T T D A L S A V I V S V L P T L K C S S Q C R
29
G D+ P+T T V I V V +L S+C+
1
G D V Q P E T T P F C V G V I V G V T I S L---S K C K
26
37.5%
NZ_JAQQWR010000009.1:
Lanthipeptides: PQ473_RS20130_lanthipeptide
1
G D I T P Q T T D A-L S A V I V S V L P T L K C S S Q C R
29
G D+ P+T T A V I +V L ++C R
1
G D V N P E T T P A C F Y G V I G T V--G L F S V A K C R
28

#### MIBiG 4.0 matches for WR47_RS28825

18.8%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
18
V L P T L K C S S Q C
28
P T K C+S+C
16
F C P T T K C T S K C
26
16.2%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
20
P T L K C S S Q C
28
P T K C+S+C
29
P T T K C T S R C
37
WR47_RS28830
Leader:
MSKNEVKALRNPKMRTEDFNNPVGIVNEQELRQIVGA
WR47_RS28835
Leader:
MSKNEVKALRNPKMRTEDFNNPVGIVNEQELRQIVGA
Shared core:
G D V T P Q A T P T V T I L A T A A G G A V I S A V L P T L K C S S K C R T D L
Core with dehydrations:
G D V Dhb P Q A Dhb P Dhb V Dhb I L A Dhb A A G G A V I Dha A V L P Dhb L K Cys Dha Dha K Cys R Dhb D L

#### antiSMASH-DB 4.0 matches for WR47_RS28830

100.0%
NZ_CP011152.1 and 3 others:
NZ_CP011152.1 Lanthipeptides: WR47_RS28830_lanthipeptide NZ_CP011152.1 Lanthipeptides: WR47_RS28835_lanthipeptide NZ_CP011152.1 Lanthipeptides: WR47_RS28830_lanthipeptide
Lanthipeptides: WR47_RS28835_lanthipeptide
1
G D V T P Q A T P T V T I L A T A A G G A V I S A V L P T L K C S S K C R T D L
40
G D V T P Q A T P T V T I L A T A A G G A V I S A V L P T L K C S S K C R T D L
1
G D V T P Q A T P T V T I L A T A A G G A V I S A V L P T L K C S S K C R T D L
40
60.0%
NZ_CP011152.1 and 1 other:
NZ_CP011152.1 Lanthipeptides: WR47_RS28825_lanthipeptide
Lanthipeptides: WR47_RS28825_lanthipeptide
1
G D V T P Q A T P T V T I L A T A A G G A V I S A V L P T L K C S S K C R T D L
40
G D+T P Q T A A V I +V L P T L K C S S+C R T D L
1
G D I T P Q T T D--------A L S A V I V S V L P T L K C S S Q C R T D L
32
52.5%
NZ_CP009280.1 and 1 other:
NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide
Lanthipeptides: P40081_RS37160_lanthipeptide
1
G D V T P Q A T P T V T I L A T A A G G A V-I S A V L-P T L K C S S K C
36
G D V P+ T P T G A V I S A L P T K C+S K C
2
G D V N P E T T P L T T S S W P C V I G A V D I S A N L C P T T K C T S K C
39
with 114 more sequence matches
Only the first 10 are displayed here.
47.5%
NZ_CP085411.1 and 1 other:
NZ_CP085411.1 Lanthipeptides: LIT28_RS29915_lanthipeptide
Lanthipeptides: LIT28_RS29915_lanthipeptide
1
G D V T P Q A T P T V T I L A T A A G G A V I S A V L P T L K C S S K C
36
G D V P+ T P T + T G A I S V P T K C+S+C
1
G D V N P E T T P T T A T V T T V L V G A T I S-V C P T T K C T S R C
35
45.0%
NC_018499.1 and 5 others:
NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27845_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide
Lanthipeptides: BCK_RS27845_lanthipeptide
1
G D V T P Q A T P-T V T I L A T A A G G A V I S A V L P T L K C S S K C
36
G D V P+ T P T T I+A + G + P T K C+S K C
1
G D V N P E T T P A T P T I V A V S L G------I C P T T K C T S K C
31
45.0%
NZ_CM000721.1 and 9 others:
NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide
Lanthipeptides: BCERE0010_RS29355_lanthipeptide
1
G D V T P Q A T P-T V T I L A T A A G G A V I S A V L P T L K C S S K C
36
G D V P+ T P T T I+ A A V +++ P T K C+S+C
1
G D V N P E T T P A T P T I I G--A T I A V T A S L C P T T K C T S R C
35
45.0%
NZ_QNUC01000031.1 and 1 other:
NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23045_lanthipeptide
Lanthipeptides: DN396_RS23045_lanthipeptide
1
G D V T P Q A T P T V T I L A T A A G G A V I S A V L P T L K C S S K C
36
G D V P+ T P T + T G A I S + P T K C+S+C
1
G D V N P E T T P T T A T V T T V L V G A T I S-I C P T T K C T S R C
35
42.5%
NZ_CP013862.1 and 1 other:
NZ_CP013862.1 Lanthipeptides: AOX59_RS09365_lanthipeptide
Lanthipeptides: AOX59_RS09365_lanthipeptide
1
G D V T P Q A T P T V T I L A T A A G G A V I S A V L P T L K C S S K C
36
G D V P Q T P+ + A G A V + P T K C+S+C
1
G D V D P Q T T P S----S V A C G I A V S A L F C P T T K C T S Q C
32
42.5%
NZ_CP036019.1 and 1 other:
NZ_CP036019.1 Lanthipeptides: EXW52_RS27205_lanthipeptide
Lanthipeptides: EXW52_RS27205_lanthipeptide
1
G D V T P Q A T P-T V T I L A T A A G G A V I S A V L P T L K C S S K C
36
G D V+P+ T P T T I+ A+ + P T K C+S K C
1
G D V S P E T T P A T P T I V V-----A I S V G L C P T T K C T S K C
32
42.5%
NZ_JAQDYA010000001.1:
Lanthipeptides: PGT72_RS00025_lanthipeptide
1
G D V T P Q A T P----T V T I L A T A A G G--A V I S A V L P T L K C
32
G D+T P+ T P T V A A G A V V L K C
1
G D I T P E T T P V C A A T V A S S A Y C A G A A S A V S G I V L S V F K C
38
42.5%
NZ_NUML01000015.1:
Lanthipeptides: COD66_RS20140_lanthipeptide
1
G D V T P Q A T P-T V T I L A T A A G G A V I S A V L P T L K C S S K C
36
G D V+P+ T P T T I+ + G + P T K C+S K C
1
G D V S P E T T P A T P T I V V G I S V G-----L C P T T K C T S K C
32
42.5%
NZ_NVJC01000007.1:
Lanthipeptides: COM38_RS07270_lanthipeptide
1
G D V T P Q A T P T V T I L A T A A G G A V I S A V L P T L K C
32
G D V P+ T P T + T G A I S V P T K C
1
G D V N P E T T P T T A T V T T V L V G A T I S-V C P T T K C
31
40.0%
NC_006322.1 and 7 others:
NC_006322.1 Lanthipeptides: BLI_RS20290_lanthipeptide NZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptide NZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptide NZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptide NZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptide NZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptide NZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptide
Lanthipeptides: BLI_RS20290_lanthipeptide
1
G D V T P Q A T P T V T I L A T A--A G G A V I S A V L P T L K C S S K C
36
D V P+ T P T T A G V +++ P T K C+S+C
1
N D V N P E T T P A T T S S W T C I T A G V T V S A S L C P T T K C T S R C
38

#### MIBiG 4.0 matches for WR47_RS28830

32.5%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
13
I L A T A A G G A V--I S A V L P T L K C S S K C
36
I+A A G A V +A P T K C+S+C
12
I V A I Q A G V A V G V S A A F C P T T K C T S R C
37
17.5%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
26
V L P T L K C S S K C
36
P T K C+S K C
16
F C P T T K C T S K C
26
allorf_279614_279820
Leader:
MVSSSSPLILNVSFGF
Core:
V I T Q T T I S S L M T V V A L S N T K S I K S I Y I I L M I L F P R I P S F S F K I S L S L C Q P C P
Core with dehydrations:
V I Dhb Q Dhb Dhb I Dha Dha L M Dhb V V A L Dha N Dhb K Dha I K Dha I Y I I L M I L F P R I P Dha F Dha F K I Dha L Dha L Cys Q P Cys P

#### antiSMASH-DB 4.0 matches for allorf_279614_279820

15.4%
NZ_QKUF01000008.1:
Lanthipeptides: allorf_238869_239036_lanthipeptide
24
S I Y I I L M I L F
33
S I Y I I L M+L+
13
S I Y I I L M V L Y
22

#### MIBiG 4.0 matches for allorf_279614_279820

5.8%
BGC0000553.3 (SSGG_RS09925):
Lanthipeptide: SRO15-2212
42
K I S L S L C Q
49
++S L +C+
4
Q V S L L V C E
11
allorf_280153_280365
Leader:
MGVMDKRKDTLRCPPPTYKSNLYFIHFIQYG
Core:
D D G L C I A L E P N H A I S I S G H H D I Q N Q S F I V F R Q K T P S S K M
Core with dehydrations:
D D G L Cys I A L E P N H A I Dha I Dha G H H D I Q N Q Dha F I V F R Q K Dhb P Dha Dha K M
allorf_299763_299852
Leader:
MFKKEYFRIYIIAAVLGS
Core:
L L T C F Y Y Y Y Y K
Core with dehydrations:
L L Dhb Cys F Y Y Y Y Y K

#### antiSMASH-DB 4.0 matches for allorf_299763_299852

100.0%
NZ_CP011152.1:
Lanthipeptides: allorf_299763_299852_lanthipeptide
1
L L T C F Y Y Y Y Y K
11
L L T C F Y Y Y Y Y K
1
L L T C F Y Y Y Y Y K
11

#### Lanthipeptide(s) for WR47_RS28840

WR47_RS28810
Leader:
MKNNSIMRFWKDPLYRMDLSSDERGNMPGS
Core:
P V G D S L E E I Q G N E L L N A V G A G D V Q A N T S T V Q I L T P R T P I I S N T L G N K G H A C T I T K E C Q N M C N
Core with dehydrations:
P V G D Dha L E E I Q G N E L L N A V G A G D V Q A N Dhb Dha Dhb V Q I L Dhb P R Dhb P I I Dha N Dhb L G N K G H A Cys Dhb I Dhb K E Cys Q N M Cys N

#### antiSMASH-DB 4.0 matches for WR47_RS28810

100.0%
NZ_CP011152.1 and 1 other:
NZ_CP011152.1 Lanthipeptides: WR47_RS28810_lanthipeptide
Lanthipeptides: WR47_RS28810_lanthipeptide
1
P V G D S L E E I Q G N E L L N A V G A G D V Q A N T S T V Q I L T P R T P I I S N T L G N K G H A C T I T K E C Q N M C N
62
P V G D S L E E I Q G N E L L N A V G A G D V Q A N T S T V Q I L T P R T P I I S N T L G N K G H A C T I T K E C Q N M C N
1
P V G D S L E E I Q G N E L L N A V G A G D V Q A N T S T V Q I L T P R T P I I S N T L G N K G H A C T I T K E C Q N M C N
62
84.4%
NZ_CP011152.1 and 3 others:
NZ_CP011152.1 Lanthipeptides: WR47_RS28815_lanthipeptide NZ_CP011152.1 Lanthipeptides: WR47_RS28820_lanthipeptide NZ_CP011152.1 Lanthipeptides: WR47_RS28815_lanthipeptide
Lanthipeptides: WR47_RS28820_lanthipeptide
1
P V G D S L E E I Q G N E L L N A V G A G D V Q A N T S T V Q I--L T P R T P I I S N T L G N K G H A C T I T K E C Q N M C N
62
P V G D S L E E I Q G N E L L N A V G A G D V Q A N T+T+ + L T ++P I S N T L G N K G H A C T I T K E C Q N M C N
1
P V G D S L E E I Q G N E L L N A V G A G D V Q A N T N T I V V T Q L T A K S P Y I S N T L G N K G H A C T I T K E C Q N M C N
64
30.6%
NZ_CP009288.1 and 3 others:
NZ_CP009288.1 Lanthipeptides: PDUR_RS25150_lanthipeptide NZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptide NZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptide
Lanthipeptides: PDUR_RS25150_lanthipeptide
33
L T P R T P I-I S N T L G N K G H A C T I T K E C Q N M C N
62
L T T I I S T L G N G C T T K E C C N
6
L T T S T S I L I S M T L G N N G W V C T A T K E C M P S C N
36
with 112 more sequence matches
Only the first 10 are displayed here.
29.0%
NZ_JALGRP010000007.1 and 1 other:
NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide
Lanthipeptides: MT347_RS12955_lanthipeptide
24
Q A N T S T V Q I L T P R T P I I S N T L G N K G H A C T I T K E C Q N M C N
62
Q T+T+ L T +S G N G C T T E C Q N C N
3
Q G W T T T I T S L T C Y G--V S W V A G N N G Q V C T A T V E C Q N N C N
39
27.4%
NZ_BMFU01000012.1 and 5 others:
NZ_BMFU01000012.1 Lanthipeptides: IEW26_RS25375_lanthipeptide NZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23855_lanthipeptide NZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23855_lanthipeptide NZ_VDYW01000008.1 Lanthipeptides: FS579_RS24445_lanthipeptide NZ_VDYW01000008.1 Lanthipeptides: FS579_RS24445_lanthipeptide
Lanthipeptides: IEW26_RS25375_lanthipeptide
21
G D V Q A N T S T V Q I L T P R T P I I S N T L G N K G H A C T I T K E C Q N M C N
62
G Q V I + S +G N G H C T+T E C Q C N
1
G A A Q P E W V E V I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C N
42
27.4%
NZ_CP009280.1 and 1 other:
NZ_CP009280.1 Lanthipeptides: P40081_RS01820_lanthipeptide
Lanthipeptides: P40081_RS01820_lanthipeptide
33
L T P R T P I-I S N T L G N K G H A C T I T K E C Q N M C N
62
L T T I I S L G N G C T +K E C C N
6
L T T S T S I F I S R G L G N D G W V C T W S K E C M P S C N
36
27.4%
NZ_CP084530.1 and 1 other:
NZ_CP084530.1 Lanthipeptides: LDO05_RS02075_lanthipeptide
Lanthipeptides: LDO05_RS02075_lanthipeptide
34
T P R T P I I S N T L G N K G H A C T I T K E C Q N M C N
62
T T +S N L G N G C T+T K E C Q C N
2
T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
30
27.4%
NZ_JACHKG010000014.1 and 1 other:
NZ_JACHKG010000014.1 Lanthipeptides: allorf_027480_027638_lanthipeptide
Lanthipeptides: allorf_027480_027638_lanthipeptide
21
G D V Q A N T S T V Q I L T P R T P I I S N T L G N K G H A C T I T K E C Q N M C N
62
G Q + V I + S +G N G H C T+T E C Q C N
1
G A A Q P Q W A E V I I T S L A C A A A S Y F M G N P G H V C T L T V E C Q K S C N
42
27.4%
NZ_LT985747.1 and 1 other:
NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide
Lanthipeptides: C8268_RS00165_lanthipeptide
34
T P R T P I I S N T L G N K G H A C T I T K E C Q N M C N
62
T T +S+ L G N K G C T+T K E C Q C N
2
T T N T F T L S D Y L G N K G G W C T L T K E C Q R S C N
30
25.8%
NZ_BJTV01000004.1 and 1 other:
NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS10200_lanthipeptide
Lanthipeptides: TNCT1_RS10200_lanthipeptide
34
T P R T P I I S N T L G N K G H A C T I T K E C Q N M C N
62
T T +S+ L G N G C T+T K E C Q C N
2
T T N T F S L S D A L G N H G G W C T L T K E C Q A N C N
30
25.8%
NZ_BNBV01000031.1 and 1 other:
NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22995_lanthipeptide
Lanthipeptides: IE286_RS22995_lanthipeptide
34
T P R T P I I S N T L G N K G H A C T I T K E C Q N M C N
62
T T +S+ L G N G C T+T K E C Q C N
2
T T N T F S L S D A L G N S G G W C T L T K E C Q P N C N
30
25.8%
NZ_CM000756.1 and 7 others:
NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS34475_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide
Lanthipeptides: BTHUR0011_RS34475_lanthipeptide
34
T P R T P I I S N T L G N K G H A C T I T K E C Q N M C
61
T + I I S T G N K G C T T E C N C
9
T S T S I I I S E T F G N K G K V C T Y T V E C V N N C
36
25.8%
NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide
Lanthipeptides: CWT12_RS00385_lanthipeptide
38
P I I S N T L G N K G H A C T I T K E C Q N M C N
62
P +S L G N G+ C T+T K E C Q M C N
3
P W L S R K L G N T G Y V C T L T K E C Q R M C N
27

#### MIBiG 4.0 matches for WR47_RS28810

27.4%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
34
T P R T P I I S N T L G N K G H A C T I T K E C Q N M C N
62
T T +S N L G N G C T+T K E C Q C N
2
T T N T F S L S N A L G N N G G W C T L T K E C Q P N C N
30
22.6%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
40
I S N T L G N K G H A C T I T K E C Q N M C N
62
I S L G N K G C T+T E C C N
6
I S C R L G N K G A Y C T L T V E C M P S C N
28
12.9%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
51
C T I T K E C Q N M C N
62
C T++K E C Q C N
28
C T L S K E C Q P N C N
39
with 1 more sequence matches
8.1%
BGC0000582.4 (ADR72962.1):
Linaridin: cypemycin
34
T P R T P I I S N T L G N K G H A C T I
53
T P T P ++ + C +
2
T P A T P T V A Q F V I Q G S T I C L V
21
WR47_RS28815
Leader:
MKNNSIMRFWKDPLYRMDLSSDERGNMPGS
WR47_RS28820
Leader:
MKNNSIMRFWKDPLYRMDLSSDERGNMPGS
Shared core:
P V G D S L E E I Q G N E L L N A V G A G D V Q A N T N T I V V T Q L T A K S P Y I S N T L G N K G H A C T I T K E C Q N M C N
Core with dehydrations:
P V G D Dha L E E I Q G N E L L N A V G A G D V Q A N Dhb N Dhb I V V Dhb Q L Dhb A K Dha P Y I Dha N Dhb L G N K G H A Cys Dhb I Dhb K E Cys Q N M Cys N

#### antiSMASH-DB 4.0 matches for WR47_RS28815

100.0%
NZ_CP011152.1 and 3 others:
NZ_CP011152.1 Lanthipeptides: WR47_RS28815_lanthipeptide NZ_CP011152.1 Lanthipeptides: WR47_RS28820_lanthipeptide NZ_CP011152.1 Lanthipeptides: WR47_RS28815_lanthipeptide
Lanthipeptides: WR47_RS28820_lanthipeptide
1
P V G D S L E E I Q G N E L L N A V G A G D V Q A N T N T I V V T Q L T A K S P Y I S N T L G N K G H A C T I T K E C Q N M C N
64
P V G D S L E E I Q G N E L L N A V G A G D V Q A N T N T I V V T Q L T A K S P Y I S N T L G N K G H A C T I T K E C Q N M C N
1
P V G D S L E E I Q G N E L L N A V G A G D V Q A N T N T I V V T Q L T A K S P Y I S N T L G N K G H A C T I T K E C Q N M C N
64
84.4%
NZ_CP011152.1 and 1 other:
NZ_CP011152.1 Lanthipeptides: WR47_RS28810_lanthipeptide
Lanthipeptides: WR47_RS28810_lanthipeptide
1
P V G D S L E E I Q G N E L L N A V G A G D V Q A N T N T I V V T Q L T A K S P Y I S N T L G N K G H A C T I T K E C Q N M C N
64
P V G D S L E E I Q G N E L L N A V G A G D V Q A N T+T+ + L T ++P I S N T L G N K G H A C T I T K E C Q N M C N
1
P V G D S L E E I Q G N E L L N A V G A G D V Q A N T S T V Q I--L T P R T P I I S N T L G N K G H A C T I T K E C Q N M C N
62
28.1%
NZ_CP009280.1 and 1 other:
NZ_CP009280.1 Lanthipeptides: P40081_RS01820_lanthipeptide
Lanthipeptides: P40081_RS01820_lanthipeptide
26
N T N T I V V T Q L T A K S P Y I S N T L G N K G H A C T I T K E C Q N M C N
64
+T N T+ T+ S +I S L G N G C T +K E C C N
2
D T N T L T----T S T S I F I S R G L G N D G W V C T W S K E C M P S C N
36
with 111 more sequence matches
Only the first 10 are displayed here.
28.1%
NZ_CP009288.1 and 3 others:
NZ_CP009288.1 Lanthipeptides: PDUR_RS25150_lanthipeptide NZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptide NZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptide
Lanthipeptides: PDUR_RS25150_lanthipeptide
33
T Q L T A K S P Y I S N T L G N K G H A C T I T K E C Q N M C N
64
T T+ S I S T L G N G C T T K E C C N
5
T L T T S T S I L I S M T L G N N G W V C T A T K E C M P S C N
36
28.1%
NZ_JALIRS010000003.1 and 3 others:
NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07255_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide
Lanthipeptides: MOK21_RS07255_lanthipeptide
29
T I V V T Q L T A K S P Y I S N T L G N K G H A C T I T K E C Q N M C N
64
T I+ + A + Y I L G N G H C T+T E C Q C N
8
T I L T S L A C A A A S Y I---L G N P G H V C T L T V E C Q K K C N
40
26.6%
NZ_BMFU01000012.1 and 5 others:
NZ_BMFU01000012.1 Lanthipeptides: IEW26_RS25375_lanthipeptide NZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23855_lanthipeptide NZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23855_lanthipeptide NZ_VDYW01000008.1 Lanthipeptides: FS579_RS24445_lanthipeptide NZ_VDYW01000008.1 Lanthipeptides: FS579_RS24445_lanthipeptide
Lanthipeptides: IEW26_RS25375_lanthipeptide
21
G D V Q A N T N T I V V T Q L T A K S P Y I S N T L G N K G H A C T I T K E C Q N M C N
64
G Q +++T L + S +G N G H C T+T E C Q C N
1
G A A Q P E W V E V I I T S L A C A A A--S Y F M G N P G H V C T L T V E C Q K S C N
42
26.6%
NZ_CM000756.1 and 7 others:
NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS34475_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide
Lanthipeptides: BTHUR0011_RS34475_lanthipeptide
33
T Q L T A K S P Y I S N T L G N K G H A C T I T K E C Q N M C
63
T T+ S I S T G N K G C T T E C N C
6
T T A T S T S I I I S E T F G N K G K V C T Y T V E C V N N C
36
26.6%
NZ_CP017953.1 and 27 others:
NZ_CP017953.1 Lanthipeptides: BAMY_RS16400_lanthipeptide NZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptide NZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptide NZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptide NZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptide NZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptide NZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptide NZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptide NZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptide NZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptide NZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptide NZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptide NZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptide NZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptide NZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptide NZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptide NZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptide NZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptide NZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptide NZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptide NZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptide NZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptide NZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptide NZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptide NZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptide
Lanthipeptides: BAMY_RS16400_lanthipeptide
28
N T I V V T Q L T A K S P Y I S N T L G N K G H A C T I T K E C Q N M C
63
N T T + +S L G N K G C T T K E C Q C
2
N T W N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
37
26.6%
NZ_JACHKG010000014.1 and 1 other:
NZ_JACHKG010000014.1 Lanthipeptides: allorf_027480_027638_lanthipeptide
Lanthipeptides: allorf_027480_027638_lanthipeptide
21
G D V Q A N T N T I V V T Q L T A K S P Y I S N T L G N K G H A C T I T K E C Q N M C N
64
G Q +++T L + S +G N G H C T+T E C Q C N
1
G A A Q P Q W A E V I I T S L A C A A A--S Y F M G N P G H V C T L T V E C Q K S C N
42
26.6%
NZ_JALGRP010000007.1 and 1 other:
NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide
Lanthipeptides: MT347_RS12955_lanthipeptide
29
T I V V T Q L T A K S P Y I S N T L G N K G H A C T I T K E C Q N M C N
64
T +T L T +S G N G C T T E C Q N C N
6
T T T I T S L T C Y G--V S W V A G N N G Q V C T A T V E C Q N N C N
39
25.0%
NZ_BMRY01000003.1 and 24 others:
NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptide NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptide NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptide NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptide NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide
Lanthipeptides: IE140_RS12370_lanthipeptide
29
T I V V T Q L T A K S P Y I S N T L G N K G H A C T I T K E C Q N M C
63
T I V + + Y+ L G N G+ C T T E C Q N C
6
T I V S S L S C Y G A S Y V---L G N N G N F C T A T A E C Q N N C
37
25.0%
NZ_CKMQ01000043.1 and 10 others:
NZ_CKMQ01000043.1 Lanthipeptides: AE832_RS11585_lanthipeptide NZ_CKMR01000002.1 Lanthipeptides: AD782_RS11690_lanthipeptide NZ_CKMR01000002.1 Lanthipeptides: AD782_RS11690_lanthipeptide NZ_FIXU01000003.1 Lanthipeptides: A1M11_RS11670_lanthipeptide NZ_FIXU01000003.1 Lanthipeptides: A1M11_RS11670_lanthipeptide NZ_LR216041.1 Lanthipeptides: E0F00_RS05465_lanthipeptide NZ_LR216046.1 Lanthipeptides: E0E82_RS05980_lanthipeptide NZ_LR216046.1 Lanthipeptides: E0E82_RS05980_lanthipeptide NZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00170_lanthipeptide NZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00170_lanthipeptide
Lanthipeptides: AE832_RS11585_lanthipeptide
37
A K S P Y I S N T L G N K G H A C T I T K E C Q N M C N
64
A+ +I S L G N K G C T T E C Q N C
3
A Q L S F I S E A L G N K G A V C T G T I E C Q N N C R
30
25.0%
NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide
Lanthipeptides: CWT12_RS00385_lanthipeptide
40
P Y I S N T L G N K G H A C T I T K E C Q N M C N
64
P++S L G N G+ C T+T K E C Q M C N
3
P W L S R K L G N T G Y V C T L T K E C Q R M C N
27

#### MIBiG 4.0 matches for WR47_RS28815

23.4%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
42
I S N T L G N K G H A C T I T K E C Q N M C N
64
+S N L G N G C T+T K E C Q C N
8
L S N A L G N N G G W C T L T K E C Q P N C N
30
21.9%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
42
I S N T L G N K G H A C T I T K E C Q N M C N
64
I S L G N K G C T+T E C C N
6
I S C R L G N K G A Y C T L T V E C M P S C N
28
12.5%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
53
C T I T K E C Q N M C N
64
C T++K E C Q C N
28
C T L S K E C Q P N C N
39
WR47_RS28825
Leader:
MSKNEVKSLRDPKMRTEDFNNPVGIVNEQELKQIVGA
Core:
G D I T P Q T T D A L S A V I V S V L P T L K C S S Q C R T D L
Core with dehydrations:
G D I Dhb P Q Dhb Dhb D A L Dha A V I V Dha V L P Dhb L K Cys Dha Dha Q Cys R Dhb D L

#### antiSMASH-DB 4.0 matches for WR47_RS28825

100.0%
NZ_CP011152.1 and 1 other:
NZ_CP011152.1 Lanthipeptides: WR47_RS28825_lanthipeptide
Lanthipeptides: WR47_RS28825_lanthipeptide
1
G D I T P Q T T D A L S A V I V S V L P T L K C S S Q C R T D L
32
G D I T P Q T T D A L S A V I V S V L P T L K C S S Q C R T D L
1
G D I T P Q T T D A L S A V I V S V L P T L K C S S Q C R T D L
32
60.0%
NZ_CP011152.1 and 3 others:
NZ_CP011152.1 Lanthipeptides: WR47_RS28830_lanthipeptide NZ_CP011152.1 Lanthipeptides: WR47_RS28835_lanthipeptide NZ_CP011152.1 Lanthipeptides: WR47_RS28830_lanthipeptide
Lanthipeptides: WR47_RS28835_lanthipeptide
1
G D I T P Q T T D--------A L S A V I V S V L P T L K C S S Q C R T D L
32
G D+T P Q T A A V I +V L P T L K C S S+C R T D L
1
G D V T P Q A T P T V T I L A T A A G G A V I S A V L P T L K C S S K C R T D L
40
46.9%
NZ_CP013862.1 and 1 other:
NZ_CP013862.1 Lanthipeptides: AOX59_RS09365_lanthipeptide
Lanthipeptides: AOX59_RS09365_lanthipeptide
1
G D I T P Q T T D A L S A V I V S V----L P T L K C S S Q C
28
G D+ P Q T T + A ++V P T K C+S Q C
1
G D V D P Q T T P S S V A C G I A V S A L F C P T T K C T S Q C
32
with 88 more sequence matches
Only the first 10 are displayed here.
43.8%
NC_018499.1 and 5 others:
NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27845_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide
Lanthipeptides: BCK_RS27845_lanthipeptide
1
G D I T P Q T T D A---L S A V I V S V L P T L K C S S Q C
28
G D+ P+T T A + A V + + P T K C+S+C
1
G D V N P E T T P A T P T I V A V S L G I C P T T K C T S K C
31
42.9%
NZ_CM000721.1 and 9 others:
NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide
Lanthipeptides: BCERE0010_RS29355_lanthipeptide
1
G D I T P Q T T D A L S-------A V I V S V L P T L K C S S Q C
28
G D+ P+T T A A V S+ P T K C+S+C
1
G D V N P E T T P A T P T I I G A T I A V T A S L C P T T K C T S R C
35
40.6%
NZ_CP036019.1 and 1 other:
NZ_CP036019.1 Lanthipeptides: EXW52_RS27205_lanthipeptide
Lanthipeptides: EXW52_RS27205_lanthipeptide
1
G D I T P Q T T D A L S A V I V S V----L P T L K C S S Q C
28
G D++P+T T A ++V++ P T K C+S+C
1
G D V S P E T T P A T P T I V V A I S V G L C P T T K C T S K C
32
40.6%
NZ_MLKL01000042.1:
Lanthipeptides: BKK45_RS27405_lanthipeptide
1
G D I T P Q T T D A---L S A V I V S V L P T L K C S S Q C
28
G D+ P+T T A + A V V + P T C+ C
1
G D V N P E T T P A T P T I V A V S V K L C P T G V C T K S C
31
40.6%
NZ_NUML01000015.1:
Lanthipeptides: COD66_RS20140_lanthipeptide
1
G D I T P Q T T D A L S A V I V S V----L P T L K C S S Q C
28
G D++P+T T A ++V + P T K C+S+C
1
G D V S P E T T P A T P T I V V G I S V G L C P T T K C T S K C
32
40.0%
NZ_CP015591.1 and 15 others:
NZ_CP078085.1 Lanthipeptides: KU891_RS29355_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29350_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29345_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29340_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29335_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptide
Lanthipeptides: A7A70_RS27550_lanthipeptide
1
G D I T P Q T T D A L S A V I-------V S V L P T L K C S S Q C
28
G D+ P+T T A ++ V S+ P T K C+S+C
1
G D V N P E T T P A T P T I V E A T I A A T V S I C P T T K C T S R C
35
38.5%
NZ_CP009288.1 and 3 others:
NZ_CP009288.1 Lanthipeptides: PDUR_RS29295_lanthipeptide NZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptide NZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptide
Lanthipeptides: PDUR_RS29295_lanthipeptide
1
G D I T P Q T T----------D A L S A V I V S V L P T L K C S S Q C
28
G D+ P+T T A V S+ P T K C+S Q C
2
G D V N P E T T I L T T S S W T C I T A G V T V S A S L C P T T K C T S Q C
39
37.5%
NZ_CP036019.1 and 7 others:
NZ_CP036019.1 Lanthipeptides: EXW52_RS27180_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27175_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27170_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27190_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27180_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27175_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27170_lanthipeptide
Lanthipeptides: EXW52_RS27190_lanthipeptide
1
G D I T P Q T T D A L S A V I V S V----L P T L K C S S Q C
28
G D++P+T T A ++V++ P T +C+S+C
1
G D V S P E T T P A T P T I V V A I S V G L C P T N R C T S K C
32
37.5%
NZ_JACSMH010000008.1 and 2 others:
NZ_JACSMX010000006.1 Lanthipeptides: KNQ03_RS15615_lanthipeptide NZ_JACSMZ010000005.1 Lanthipeptides: KNQ06_RS16025_lanthipeptide
Lanthipeptides: KNP89_RS14470_lanthipeptide
1
G D I T P Q T T D A L S A V I V S V L P T L K C S S Q C R
29
G D+ P+T T V I V V +L S+C+
1
G D V Q P E T T P F C V G V I V G V T I S L---S K C K
26
37.5%
NZ_JAQQWR010000009.1:
Lanthipeptides: PQ473_RS20130_lanthipeptide
1
G D I T P Q T T D A-L S A V I V S V L P T L K C S S Q C R
29
G D+ P+T T A V I +V L ++C R
1
G D V N P E T T P A C F Y G V I G T V--G L F S V A K C R
28

#### MIBiG 4.0 matches for WR47_RS28825

18.8%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
18
V L P T L K C S S Q C
28
P T K C+S+C
16
F C P T T K C T S K C
26
16.2%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
20
P T L K C S S Q C
28
P T K C+S+C
29
P T T K C T S R C
37
WR47_RS28830
Leader:
MSKNEVKALRNPKMRTEDFNNPVGIVNEQELRQIVGA
WR47_RS28835
Leader:
MSKNEVKALRNPKMRTEDFNNPVGIVNEQELRQIVGA
Shared core:
G D V T P Q A T P T V T I L A T A A G G A V I S A V L P T L K C S S K C R T D L
Core with dehydrations:
G D V Dhb P Q A Dhb P Dhb V Dhb I L A Dhb A A G G A V I Dha A V L P Dhb L K Cys Dha Dha K Cys R Dhb D L

#### antiSMASH-DB 4.0 matches for WR47_RS28830

100.0%
NZ_CP011152.1 and 3 others:
NZ_CP011152.1 Lanthipeptides: WR47_RS28830_lanthipeptide NZ_CP011152.1 Lanthipeptides: WR47_RS28835_lanthipeptide NZ_CP011152.1 Lanthipeptides: WR47_RS28830_lanthipeptide
Lanthipeptides: WR47_RS28835_lanthipeptide
1
G D V T P Q A T P T V T I L A T A A G G A V I S A V L P T L K C S S K C R T D L
40
G D V T P Q A T P T V T I L A T A A G G A V I S A V L P T L K C S S K C R T D L
1
G D V T P Q A T P T V T I L A T A A G G A V I S A V L P T L K C S S K C R T D L
40
60.0%
NZ_CP011152.1 and 1 other:
NZ_CP011152.1 Lanthipeptides: WR47_RS28825_lanthipeptide
Lanthipeptides: WR47_RS28825_lanthipeptide
1
G D V T P Q A T P T V T I L A T A A G G A V I S A V L P T L K C S S K C R T D L
40
G D+T P Q T A A V I +V L P T L K C S S+C R T D L
1
G D I T P Q T T D--------A L S A V I V S V L P T L K C S S Q C R T D L
32
52.5%
NZ_CP009280.1 and 1 other:
NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide
Lanthipeptides: P40081_RS37160_lanthipeptide
1
G D V T P Q A T P T V T I L A T A A G G A V-I S A V L-P T L K C S S K C
36
G D V P+ T P T G A V I S A L P T K C+S K C
2
G D V N P E T T P L T T S S W P C V I G A V D I S A N L C P T T K C T S K C
39
with 114 more sequence matches
Only the first 10 are displayed here.
47.5%
NZ_CP085411.1 and 1 other:
NZ_CP085411.1 Lanthipeptides: LIT28_RS29915_lanthipeptide
Lanthipeptides: LIT28_RS29915_lanthipeptide
1
G D V T P Q A T P T V T I L A T A A G G A V I S A V L P T L K C S S K C
36
G D V P+ T P T + T G A I S V P T K C+S+C
1
G D V N P E T T P T T A T V T T V L V G A T I S-V C P T T K C T S R C
35
45.0%
NC_018499.1 and 5 others:
NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27845_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide
Lanthipeptides: BCK_RS27845_lanthipeptide
1
G D V T P Q A T P-T V T I L A T A A G G A V I S A V L P T L K C S S K C
36
G D V P+ T P T T I+A + G + P T K C+S K C
1
G D V N P E T T P A T P T I V A V S L G------I C P T T K C T S K C
31
45.0%
NZ_CM000721.1 and 9 others:
NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide
Lanthipeptides: BCERE0010_RS29355_lanthipeptide
1
G D V T P Q A T P-T V T I L A T A A G G A V I S A V L P T L K C S S K C
36
G D V P+ T P T T I+ A A V +++ P T K C+S+C
1
G D V N P E T T P A T P T I I G--A T I A V T A S L C P T T K C T S R C
35
45.0%
NZ_QNUC01000031.1 and 1 other:
NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23045_lanthipeptide
Lanthipeptides: DN396_RS23045_lanthipeptide
1
G D V T P Q A T P T V T I L A T A A G G A V I S A V L P T L K C S S K C
36
G D V P+ T P T + T G A I S + P T K C+S+C
1
G D V N P E T T P T T A T V T T V L V G A T I S-I C P T T K C T S R C
35
42.5%
NZ_CP013862.1 and 1 other:
NZ_CP013862.1 Lanthipeptides: AOX59_RS09365_lanthipeptide
Lanthipeptides: AOX59_RS09365_lanthipeptide
1
G D V T P Q A T P T V T I L A T A A G G A V I S A V L P T L K C S S K C
36
G D V P Q T P+ + A G A V + P T K C+S+C
1
G D V D P Q T T P S----S V A C G I A V S A L F C P T T K C T S Q C
32
42.5%
NZ_CP036019.1 and 1 other:
NZ_CP036019.1 Lanthipeptides: EXW52_RS27205_lanthipeptide
Lanthipeptides: EXW52_RS27205_lanthipeptide
1
G D V T P Q A T P-T V T I L A T A A G G A V I S A V L P T L K C S S K C
36
G D V+P+ T P T T I+ A+ + P T K C+S K C
1
G D V S P E T T P A T P T I V V-----A I S V G L C P T T K C T S K C
32
42.5%
NZ_JAQDYA010000001.1:
Lanthipeptides: PGT72_RS00025_lanthipeptide
1
G D V T P Q A T P----T V T I L A T A A G G--A V I S A V L P T L K C
32
G D+T P+ T P T V A A G A V V L K C
1
G D I T P E T T P V C A A T V A S S A Y C A G A A S A V S G I V L S V F K C
38
42.5%
NZ_NUML01000015.1:
Lanthipeptides: COD66_RS20140_lanthipeptide
1
G D V T P Q A T P-T V T I L A T A A G G A V I S A V L P T L K C S S K C
36
G D V+P+ T P T T I+ + G + P T K C+S K C
1
G D V S P E T T P A T P T I V V G I S V G-----L C P T T K C T S K C
32
42.5%
NZ_NVJC01000007.1:
Lanthipeptides: COM38_RS07270_lanthipeptide
1
G D V T P Q A T P T V T I L A T A A G G A V I S A V L P T L K C
32
G D V P+ T P T + T G A I S V P T K C
1
G D V N P E T T P T T A T V T T V L V G A T I S-V C P T T K C
31
40.0%
NC_006322.1 and 7 others:
NC_006322.1 Lanthipeptides: BLI_RS20290_lanthipeptide NZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptide NZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptide NZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptide NZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptide NZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptide NZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptide
Lanthipeptides: BLI_RS20290_lanthipeptide
1
G D V T P Q A T P T V T I L A T A--A G G A V I S A V L P T L K C S S K C
36
D V P+ T P T T A G V +++ P T K C+S+C
1
N D V N P E T T P A T T S S W T C I T A G V T V S A S L C P T T K C T S R C
38

#### MIBiG 4.0 matches for WR47_RS28830

32.5%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
13
I L A T A A G G A V--I S A V L P T L K C S S K C
36
I+A A G A V +A P T K C+S+C
12
I V A I Q A G V A V G V S A A F C P T T K C T S R C
37
17.5%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
26
V L P T L K C S S K C
36
P T K C+S K C
16
F C P T T K C T S K C
26
WR47_RS33320
Leader:
MERVQAIYS
Core:
N Q K F K S W V K Q V L A V G G V I G C C Y L V L Y V F C F L V I M
Core with dehydrations:
N Q K F K Dha W V K Q V L A V G G V I G Cys Cys Y L V L Y V F Cys F L V I M

#### antiSMASH-DB 4.0 matches for WR47_RS33320

100.0%
NZ_CP011152.1:
Lanthipeptides: WR47_RS33320_lanthipeptide
1
N Q K F K S W V K Q V L A V G G V I G C C Y L V L Y V F C F L V I M
34
N Q K F K S W V K Q V L A V G G V I G C C Y L V L Y V F C F L V I M
1
N Q K F K S W V K Q V L A V G G V I G C C Y L V L Y V F C F L V I M
34
16.7%
NZ_CP051884.1:
Lanthipeptides: allorf_3277747_3277950_lanthipeptide
4
F K S W V K Q V L A V G G V I G C C Y L V
24
F+ W+ + + V V G C L V
27
F Q R W L P R K V G V Q V V H G C R Q L V
47

#### MIBiG 4.0 matches for WR47_RS33320

14.7%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
13
A V G G V I G C C Y L V
24
A+G G C L
11
A L G N N G G W C T L T
22
allorf_299763_299852
Leader:
MFKKEYFRIYIIAAVLGS
Core:
L L T C F Y Y Y Y Y K
Core with dehydrations:
L L Dhb Cys F Y Y Y Y Y K

#### antiSMASH-DB 4.0 matches for allorf_299763_299852

100.0%
NZ_CP011152.1:
Lanthipeptides: allorf_299763_299852_lanthipeptide
1
L L T C F Y Y Y Y Y K
11
L L T C F Y Y Y Y Y K
1
L L T C F Y Y Y Y Y K
11

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.57 out of 25.31
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.10 out of 23.79
Confidence: medium
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.16 out of 18.46
Confidence: medium
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 25.31 out of 28.14
Confidence: medium
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 24.56 out of 29.25
Confidence: medium
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.24 out of 29.25
Confidence: medium
Additional weak hits (4):
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.30 out of 27.04
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 21.71 out of 33.73
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.95 out of 20.01
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

WR47_RS28810 - Class II
  Cleavage pHMM score: 0.50
  RODEO score: 0
  Monoisotopic mass: 6297.2 Da
  Molecular weight: 6301.0 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    6319.0 Da N = 1
    6337.0 Da N = 2
    6355.1 Da N = 3
    6373.1 Da N = 4
    6391.1 Da N = 5
    6409.1 Da N = 6
    6427.1 Da N = 7
WR47_RS28815 - Class II
  Cleavage pHMM score: 0.50
  RODEO score: 0
  Monoisotopic mass: 6506.2 Da
  Molecular weight: 6510.2 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    6528.2 Da N = 1
    6546.2 Da N = 2
    6564.3 Da N = 3
    6582.3 Da N = 4
    6600.3 Da N = 5
    6618.3 Da N = 6
    6636.3 Da N = 7
WR47_RS28820 - Class II
  Cleavage pHMM score: 0.50
  RODEO score: 0
  Monoisotopic mass: 6506.2 Da
  Molecular weight: 6510.2 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    6528.2 Da N = 1
    6546.2 Da N = 2
    6564.3 Da N = 3
    6582.3 Da N = 4
    6600.3 Da N = 5
    6618.3 Da N = 6
    6636.3 Da N = 7
WR47_RS28825 - Class II
  Cleavage pHMM score: 3.50
  RODEO score: 0
  Monoisotopic mass: 3169.7 Da
  Molecular weight: 3171.6 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3189.6 Da N = 1
    3207.6 Da N = 2
    3225.7 Da N = 3
    3243.7 Da N = 4
    3261.7 Da N = 5
    3279.7 Da N = 6
    3297.7 Da N = 7
WR47_RS28830 - Class II
  Cleavage pHMM score: 3.60
  RODEO score: 0
  Monoisotopic mass: 3746.1 Da
  Molecular weight: 3748.3 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3766.4 Da N = 1
    3784.4 Da N = 2
    3802.4 Da N = 3
    3820.4 Da N = 4
    3838.4 Da N = 5
    3856.5 Da N = 6
    3874.5 Da N = 7
    3892.5 Da N = 8
WR47_RS28835 - Class II
  Cleavage pHMM score: 3.60
  RODEO score: 0
  Monoisotopic mass: 3746.1 Da
  Molecular weight: 3748.3 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3766.4 Da N = 1
    3784.4 Da N = 2
    3802.4 Da N = 3
    3820.4 Da N = 4
    3838.4 Da N = 5
    3856.5 Da N = 6
    3874.5 Da N = 7
    3892.5 Da N = 8
WR47_RS33320 - Class II
  Cleavage pHMM score: -4.10
  RODEO score: 0
  Monoisotopic mass: 3849.1 Da
  Molecular weight: 3851.7 Da
  Number of bridges: 1
allorf_299763_299852 - Class II
  Cleavage pHMM score: -4.00
  RODEO score: 0
  Monoisotopic mass: 1520.7 Da
  Molecular weight: 1521.8 Da
  Number of bridges: 1
WR47_RS28810 - Class II
  Cleavage pHMM score: 0.50
  RODEO score: 0
  Monoisotopic mass: 6297.2 Da
  Molecular weight: 6301.0 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    6319.0 Da N = 1
    6337.0 Da N = 2
    6355.1 Da N = 3
    6373.1 Da N = 4
    6391.1 Da N = 5
    6409.1 Da N = 6
    6427.1 Da N = 7
WR47_RS28815 - Class II
  Cleavage pHMM score: 0.50
  RODEO score: 0
  Monoisotopic mass: 6506.2 Da
  Molecular weight: 6510.2 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    6528.2 Da N = 1
    6546.2 Da N = 2
    6564.3 Da N = 3
    6582.3 Da N = 4
    6600.3 Da N = 5
    6618.3 Da N = 6
    6636.3 Da N = 7
WR47_RS28820 - Class II
  Cleavage pHMM score: 0.50
  RODEO score: 0
  Monoisotopic mass: 6506.2 Da
  Molecular weight: 6510.2 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    6528.2 Da N = 1
    6546.2 Da N = 2
    6564.3 Da N = 3
    6582.3 Da N = 4
    6600.3 Da N = 5
    6618.3 Da N = 6
    6636.3 Da N = 7
WR47_RS28825 - Class II
  Cleavage pHMM score: 3.50
  RODEO score: 0
  Monoisotopic mass: 3169.7 Da
  Molecular weight: 3171.6 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3189.6 Da N = 1
    3207.6 Da N = 2
    3225.7 Da N = 3
    3243.7 Da N = 4
    3261.7 Da N = 5
    3279.7 Da N = 6
    3297.7 Da N = 7
WR47_RS28830 - Class II
  Cleavage pHMM score: 3.60
  RODEO score: 0
  Monoisotopic mass: 3746.1 Da
  Molecular weight: 3748.3 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3766.4 Da N = 1
    3784.4 Da N = 2
    3802.4 Da N = 3
    3820.4 Da N = 4
    3838.4 Da N = 5
    3856.5 Da N = 6
    3874.5 Da N = 7
    3892.5 Da N = 8
WR47_RS28835 - Class II
  Cleavage pHMM score: 3.60
  RODEO score: 0
  Monoisotopic mass: 3746.1 Da
  Molecular weight: 3748.3 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3766.4 Da N = 1
    3784.4 Da N = 2
    3802.4 Da N = 3
    3820.4 Da N = 4
    3838.4 Da N = 5
    3856.5 Da N = 6
    3874.5 Da N = 7
    3892.5 Da N = 8
allorf_279614_279820 - Class II
  Cleavage pHMM score: -7.30
  RODEO score: 0
  Monoisotopic mass: 5490.2 Da
  Molecular weight: 5493.7 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    5511.7 Da N = 1
    5529.7 Da N = 2
    5547.7 Da N = 3
    5565.8 Da N = 4
    5583.8 Da N = 5
    5601.8 Da N = 6
    5619.8 Da N = 7
    5637.8 Da N = 8
    5655.9 Da N = 9
    5673.9 Da N = 10
    5691.9 Da N = 11
    5709.9 Da N = 12
allorf_280153_280365 - Class II
  Cleavage pHMM score: -7.20
  RODEO score: 0
  Monoisotopic mass: 4225.1 Da
  Molecular weight: 4227.7 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4245.7 Da N = 1
    4263.8 Da N = 2
    4281.8 Da N = 3
    4299.8 Da N = 4
    4317.8 Da N = 5
allorf_299763_299852 - Class II
  Cleavage pHMM score: -4.00
  RODEO score: 0
  Monoisotopic mass: 1520.7 Da
  Molecular weight: 1521.8 Da
  Number of bridges: 1

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CatR | H2O2-responsive repressor
IolR | Regulator of the inositol catabolism
PerR | Peroxide regulator
RpoN | Regulator of nitrogen assimilation and virulence
SypG | Regulator of biofilm formation and host colonization

NZ_CP011152.1 - Region 4 - NRPS,T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
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Location: 367,309 - 471,232 nt. (total: 103,924 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase
WR47_RS29175: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

WR47_RS29220: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

WR47_RS29235: 3-hydroxybutyryl-CoA dehydrogenase

smcogs
  SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase

WR47_RS29245: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

WR47_RS29260: oxidoreductase

smcogs
  SMCOG1083: oxidoreductase

WR47_RS29310: oxidoreductase

smcogs
  SMCOG1079: oxidoreductase

Transferases: PPTase acylase aminotransferase carbamoyltransferase
WR47_RS29230: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

WR47_RS29290: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

WR47_RS29300: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs
  SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

WR47_RS29320: ornithine carbamoyltransferase

smcogs
  SMCOG1114: ornithine carbamoyltransferase

Hydrolases: deaminase esterase hydrolase phosphatase
WR47_RS29265: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

WR47_RS29270: FkbH like protein

smcogs
  SMCOG1256: FkbH like protein

WR47_RS29280: thioesterase

smcogs
  SMCOG1004: thioesterase

WR47_RS29305: hydrolase

smcogs
  SMCOG1179: hydrolase

WR47_RS29330: ornithine cyclodeaminase

smcogs
  SMCOG1158: ornithine cyclodeaminase

Lyases: decarboxylase
WR47_RS29170: Decarboxylase, pyridoxal-dependent

smcogs
  SMCOG1180: Decarboxylase, pyridoxal-dependent

Ligases: ligase synthase
WR47_RS29180: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

WR47_RS29200: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

WR47_RS29205: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

WR47_RS29210: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

WR47_RS29250: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

WR47_RS29255: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

WR47_RS29275: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

WR47_RS29285: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

WR47_RS29325: cysteine synthase

smcogs
  SMCOG1081: cysteine synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | T1PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001059.5 |  |  | 1.44 | NRPS, PKS | zwittermicin A | Bacillus cereus
BGC0001833.4 |  |  | 0.94 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002135.2 |  |  | 0.90 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0002286.3 |  |  | 0.89 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  |  | 0.89 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  |  | 0.89 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001135.5 |  |  | 0.89 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001758.4 |  |  | 0.86 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0002075.3 |  |  | 0.86 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0001825.4 |  |  | 0.84 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001059.5 |  | 0.95 | NRPS, PKS | zwittermicin A | Bacillus cereus
BGC0001833.4 |  | 0.77 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002135.2 |  | 0.75 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0002286.3 |  | 0.75 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.75 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  | 0.75 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001135.5 |  | 0.75 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001758.4 |  | 0.74 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0002075.3 |  | 0.74 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0001825.4 |  | 0.73 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Location:
Identifier
Identity
Coverage
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 25.18 out of 26.06
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.62 out of 27.78
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.71 out of 27.78
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.01 out of 32.93
Confidence: medium
Additional weak hits (8):
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.04 out of 28.14
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 27.05 out of 39.62
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.19 out of 28.14
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.72 out of 32.74
Confidence: weak
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.81 out of 27.55
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 22.66 out of 26.12
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.13 out of 29.38
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 24.42 out of 35.63
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 4, location 367308 - 471232:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X - Tyr) + (ohmal - bOH-Tyr) + (Pro) + (X - ohmal) + (D-Asn) + (X - X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
WR47_RS29180: X - Tyr
Search NORINE for peptide: strict or relaxed
AMP-binding (477..877): X
nrpys: (unknown)

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSVAFDASIMEPVLFVGGELNAYGPTETTVCATM
  Nearest Stachelhaus code(s):
    Leu DAMLVGAVCK (71% 8Å match)
  Stachelhaus code match:
    80% (moderate)

AMP-binding (1540..1944): Tyr
nrpys: Tyr

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Polar aromatic ring (Tyr, bOH-Tyr)
  Single AA prediction:
    tyr (Tyr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LWRYFDSSVSESDLIMGGEVNEYGPTEATVSAMY
  Nearest Stachelhaus code(s):
    Lys DAEDIGTVSK (65% 8Å match)
  Stachelhaus code match:
    70% (weak)

WR47_RS29200: mal
PKS_AT (1897..2192): mal
ATSignature: 2-Rhyd-Malonyl-CoA

Top 3 matches:
  2-Rhyd-Malonyl-CoA: 95.8%
  Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 106.8
  inactive: 74.2
  Methoxymalonyl-CoA: 53.5
  Methylmalonyl-CoA: 44.8
  Propionyl-CoA: 31.2
  CHC-CoA: 15.3
  Ethylmalonyl-CoA: 14.8
  Isobutyryl-CoA: 13.3
  2-Methylbutyryl-CoA: 11.6
  3-Methylbutyryl-CoA: 9.7
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0

WR47_RS29205: bOH-Tyr - Pro
Search NORINE for peptide: strict or relaxed
AMP-binding (274..685): bOH-Tyr
nrpys: bOH-Tyr

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LGLSFDASVQNGDGIIAGETNAYGPTETTVDSTC
  Nearest Stachelhaus code(s):
    bOH-Tyr DASTIAAVDK (62% 8Å match)
  Stachelhaus code match:
    80% (moderate)

AMP-binding (1329..1728): Pro
nrpys: Pro

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    pro (Pro)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FSMTFDVSVLEGNFLLAGEENMYGPTEATVIAST
  Nearest Stachelhaus code(s):
    Ala DVHNLAIVYK (76% 8Å match)
    Ser DVWNVAMVHK (62% 8Å match)
  Stachelhaus code match:
    70% (weak)

WR47_RS29230: mal
PKS_AT (5..291): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 62.5%
  2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 51.2
  inactive: 31.2
  Methoxymalonyl-CoA: 30.8
  Methylmalonyl-CoA: 13.8
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Propionyl-CoA: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

WR47_RS29250: Ser
Search NORINE for peptide: strict or relaxed
AMP-binding (8..410): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    ser (Ser)
  Single AA prediction:
    ser (Ser)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWMTFDVSVWEWHFFVSGETNLYGPTEATIDVTA
  Nearest Stachelhaus code(s):
    Ser DVWHFSLIDK (91% 8Å match)
  Stachelhaus code match:
    100% (strong)

WR47_RS29255: X - mal
AMP-binding (448..845): X
nrpys: (unknown)

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LHQHFDMSVWEGNQTFGGEVNMYGITETTVHVTY
  Nearest Stachelhaus code(s):
    Ser DMWNTGLVHK (82% 8Å match)
  Stachelhaus code match:
    90% (moderate)

PKS_AT (1551..1847): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 100.0%
  inactive: 83.3%
  2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 136.6
  inactive: 96.6
  Methoxymalonyl-CoA: 45.5
  Methylmalonyl-CoA: 26.7
  Propionyl-CoA: 16.8
  Isobutyryl-CoA: 9.2
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

WR47_RS29275: Asn
Search NORINE for peptide: strict or relaxed
AMP-binding (461..856): Asn
nrpys: Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWASFDLTVTSTKVIVGGEINEYGPTETVVGCMI
  Nearest Stachelhaus code(s):
    Asn DLTKIGEVGK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

WR47_RS29285: X - X
AMP-binding (280..682): X
nrpys: Val, Leu, Ile, Abu, Ival

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    FAMSFDVTIFEVYIFVGVELNLYGPTEATVCCTS
  Nearest Stachelhaus code(s):
    Met DVFYLGGVFK (59% 8Å match)
    Ala DVFFVGLVAK (50% 8Å match)
    Pro DLFYLALVCK (47% 8Å match)
  Stachelhaus code match:
    70% (weak)

AMP-binding (1323..1725): X
nrpys: (unknown)

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    FAMSFDVTIFEVYILVGVELNGYGPTEATVCCTT
  Nearest Stachelhaus code(s):
    Met DVFYLGGVFK (62% 8Å match)
  Stachelhaus code match:
    90% (moderate)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 3 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes