GCF_001071295.1 - 3 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_JVCZ01000014.1 (Streptococcus parasanguinis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 12.1	terpene-precursor	21,160	42,035

NZ_JVCZ01000017.1 (Streptococcus parasanguinis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 15.1	T3PKS	1	36,182

NZ_JVCZ01000028.1 (Streptococcus parasanguinis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 25.1	lanthipeptide-class-ii	244,658	267,909	Low	thermophilin 1277	ribosomal:RiPP:Lanthipeptide

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 12.1	terpene-precursor	21,160	42,035
Region 15.1	T3PKS	1	36,182
Region 25.1	lanthipeptide-class-ii	244,658	267,909	Low	thermophilin 1277	ribosomal:RiPP:Lanthipeptide

No secondary metabolite regions were found in these records:: NZ_JVCZ01000003.1 (Streptococcus parasanguinis); NZ_JVCZ01000004.1 (Streptococcus parasanguinis); NZ_JVCZ01000005.1 (Streptococcus parasanguinis); NZ_JVCZ01000006.1 (Streptococcus parasanguinis); NZ_JVCZ01000007.1 (Streptococcus parasanguinis); NZ_JVCZ01000008.1 (Streptococcus parasanguinis); NZ_JVCZ01000009.1 (Streptococcus parasanguinis); NZ_JVCZ01000010.1 (Streptococcus parasanguinis); NZ_JVCZ01000011.1 (Streptococcus parasanguinis); NZ_JVCZ01000012.1 (Streptococcus parasanguinis); NZ_JVCZ01000013.1 (Streptococcus parasanguinis); NZ_JVCZ01000015.1 (Streptococcus parasanguinis); NZ_JVCZ01000016.1 (Streptococcus parasanguinis); NZ_JVCZ01000018.1 (Streptococcus parasanguinis); NZ_JVCZ01000020.1 (Streptococcus parasanguinis); NZ_JVCZ01000021.1 (Streptococcus parasanguinis); NZ_JVCZ01000022.1 (Streptococcus parasanguinis); NZ_JVCZ01000023.1 (Streptococcus parasanguinis); NZ_JVCZ01000024.1 (Streptococcus parasanguinis); NZ_JVCZ01000025.1 (Streptococcus parasanguinis); NZ_JVCZ01000026.1 (Streptococcus parasanguinis); NZ_JVCZ01000027.1 (Streptococcus parasanguinis); NZ_JVCZ01000029.1 (Streptococcus parasanguinis); NZ_JVCZ01000030.1 (Streptococcus parasanguinis); NZ_JVCZ01000031.1 (Streptococcus parasanguinis); NZ_JVCZ01000032.1 (Streptococcus parasanguinis); NZ_JVCZ01000033.1 (Streptococcus parasanguinis); NZ_JVCZ01000034.1 (Streptococcus parasanguinis); NZ_JVCZ01000036.1 (Streptococcus parasanguinis); NZ_JVCZ01000037.1 (Streptococcus parasanguinis); NZ_JVCZ01000038.1 (Streptococcus parasanguinis); NZ_JVCZ01000039.1 (Streptococcus parasanguinis); NZ_JVCZ01000040.1 (Streptococcus parasanguinis); NZ_JVCZ01000041.1 (Streptococcus parasanguinis); NZ_JVCZ01000001.1 (Streptococcus parasanguinis)

Compact view

NZ_JVCZ01000014.1 - Region 1 - terpene-precursor

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Location: 21,160 - 42,035 nt. (total: 20,876 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: synthetase

ADG88_RS02405: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002285.2	0.31	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0001456.3	0.31	terpene	isorenieratene	Streptomyces argillaceus
BGC0001594.3	0.29	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0000668.5	0.29	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830
BGC0001756.3	0.29	terpene	retigeranin, arathanatriene	Arabidopsis thaliana
BGC0000495.5	0.28	ribosomal	actagardine	Actinoplanes garbadinensis
BGC0001126.4	0.28	other (other), terpene	12-epi-hapalindole J isonitrile, ambiguine A isonitrile, ambiguine B isonitrile, ambiguine C isonitrile, ambiguine D isonitrile, ambiguine E isonitrile, ambiguine K isonitrile, ambiguine L isonitrile, ambiguine I isonitrile, ambiguine J isonitrile	Fischerella ambigua UTEX 1903

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002285.2	0.31	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0001456.3	0.31	terpene	isorenieratene	Streptomyces argillaceus
BGC0001594.3	0.29	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0000668.5	0.29	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830
BGC0001756.3	0.29	terpene	retigeranin, arathanatriene	Arabidopsis thaliana
BGC0000495.5	0.28	ribosomal	actagardine	Actinoplanes garbadinensis
BGC0001126.4	0.28	other (other), terpene	12-epi-hapalindole J isonitrile, ambiguine A isonitrile, ambiguine B isonitrile, ambiguine C isonitrile, ambiguine D isonitrile, ambiguine E isonitrile, ambiguine K isonitrile, ambiguine L isonitrile, ambiguine I isonitrile, ambiguine J isonitrile	Fischerella ambigua UTEX 1903

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

ADG88_RS02405: PT_FPPS_like

Domain 1 (27 - 271): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.67 out of 20.97

Confidence: medium

Additional weak hits (6):

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.24 out of 25.88

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.94 out of 27.55

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 22.66 out of 26.12

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.95 out of 26.06

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 18.92 out of 30.12

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 18.92 out of 30.12

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
ToxT	Regulator of MSHA biosynthesis

NZ_JVCZ01000017.1 - Region 1 - T3PKS

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Location: 1 - 36,182 nt. (total: 36,182 nt) Show pHMM detection rules used

Region on contig edge.

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: reductase

ADG88_RS03325: hydroxymethylglutaryl-CoA reductase

smcogs: SMCOG1187: hydroxymethylglutaryl-CoA reductase

Hydrolases: hydrolase

ADG88_RS03290: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

Ligases: synthase

ADG88_RS03330: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002561.3	0.45	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000286.3	0.41	PKS	viguiepinol	Streptomyces sp. KO-3988
BGC0000205.3	0.40	PKS	bryostatin	Candidatus Endobugula sertula
BGC0002703.2	0.39	ribosomal	archalan α	Halorussus salinus
BGC0001080.5	0.39	other (phenazine)	endophenazine A, endophenazine B	Streptomyces anulatus
BGC0000934.4	0.37	other (phenazine)	5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G	Kitasatospora sp. HKI 714
BGC0000679.5	0.31	terpene	diazepinomicin	Micromonospora sp. M42
BGC0001079.5	0.31	PKS, terpene	napyradiomycin A80915C, napyradiomycin 2, napyradiomycin 3, napyradiomycin 4	Streptomyces aculeolatus
BGC0001078.5	0.30	PKS, terpene	furaquinocin B	Streptomyces sp. KO-3988
BGC0000872.5	0.30	other (other)	A-90289 A, A-90289 B	Streptomyces sp. SANK 60405

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002561.3	0.45	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000286.3	0.41	PKS	viguiepinol	Streptomyces sp. KO-3988
BGC0000205.3	0.40	PKS	bryostatin	Candidatus Endobugula sertula
BGC0002703.2	0.39	ribosomal	archalan α	Halorussus salinus
BGC0001080.5	0.39	other (phenazine)	endophenazine A, endophenazine B	Streptomyces anulatus
BGC0000934.4	0.37	other (phenazine)	5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G	Kitasatospora sp. HKI 714
BGC0000679.5	0.31	terpene	diazepinomicin	Micromonospora sp. M42
BGC0001079.5	0.31	PKS, terpene	napyradiomycin A80915C, napyradiomycin 2, napyradiomycin 3, napyradiomycin 4	Streptomyces aculeolatus
BGC0001078.5	0.30	PKS, terpene	furaquinocin B	Streptomyces sp. KO-3988
BGC0000872.5	0.30	other (other)	A-90289 A, A-90289 B	Streptomyces sp. SANK 60405

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.11 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.70 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.67 out of 26.06

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.13 out of 20.97

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.02 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.31 out of 26.06

Confidence: medium

Additional weak hits (6):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.32 out of 30.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.45 out of 26.06

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.14 out of 31.73

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.67 out of 30.25

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 26.05 out of 30.97

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.75 out of 26.06

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes

NZ_JVCZ01000028.1 - Region 1 - lanthipeptide-class-ii

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Location: 244,658 - 267,909 nt. (total: 23,252 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

ADG88_RS08095: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.57	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000554.4	0.56	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001210.5	0.53	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000558.5	0.53	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000525.5	0.51	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000521.3	0.51	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000626.3	0.49	ribosomal	thuricin	Bacillus thuringiensis
BGC0001787.3	0.49	ribosomal	suicin 3908	Streptococcus suis
BGC0000552.3	0.49	ribosomal	SmbA, SmbB	Streptococcus mutans
BGC0000539.5	0.48	ribosomal	nukacin ISK-1	Staphylococcus warneri

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.57	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000554.4	0.56	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001210.5	0.53	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000558.5	0.53	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000525.5	0.51	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000521.3	0.51	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000626.3	0.49	ribosomal	thuricin	Bacillus thuringiensis
BGC0001787.3	0.49	ribosomal	suicin 3908	Streptococcus suis
BGC0000552.3	0.49	ribosomal	SmbA, SmbB	Streptococcus mutans
BGC0000539.5	0.48	ribosomal	nukacin ISK-1	Staphylococcus warneri

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for ADG88_RS08095

ADG88_RS11420

Leader:

MSDWKKPIYESLSTEGNPAGDILRELSDSEMDQTMAGG

Core:

TARSYCACYSGENSCGRGCTITTECPFLTFICC

Core with dehydrations:

DhbARDhaYCysACysYDhaGENDhaCysGRGCysDhbIDhbDhbECysPFLDhbFICysCys

antiSMASH-DB 4.0 matches for ADG88_RS11420

100.0%

NZ_JVCZ01000028.1:

Lanthipeptides: ADG88_RS11420_lanthipeptide

TARSYCACYSGENSCGRGCTITTECPFLTFICC

97.0%

NC_011900.1and 2 others:

NZ_NCVD01000002.1 Lanthipeptides: B7702_RS00350_lanthipeptideNZ_NCVL01000015.1 Lanthipeptides: B7694_RS04515_lanthipeptide

Lanthipeptides: SPN23F_RS06435_lanthipeptide

TARSYCACYSGENSCGRGCTITTECPFLTFICC

TARSYCACYSGE+SCGRGCTITTECPFLTFICC

TARSYCACYSGEHSCGRGCTITTECPFLTFICC

93.9%

NZ_CP102135.1:

Lanthipeptides: NQZ98_RS01500_lanthipeptide

TARSYCACYSGENSCGRGCTITTECPFLTFICC

TARSYC CYSGE+SCGRGCTITTECPFLTFICC

TARSYCGCYSGEHSCGRGCTITTECPFLTFICC

with 53 more sequence matches

Only the first 10 are displayed here.

76.5%

NZ_LR595858.1:

Lanthipeptides: FQT45_RS03330_lanthipeptide

TARSYCACYSGENSCGRGCTITTECPFLTFICC

TA SYC CYSG++SCGRGCTITTECP T ICC

TANSYCHCYSGKDSCGRGCTITTECPIATIICC

72.7%

NZ_FQTY01000002.1:

Lanthipeptides: BUB33_RS04605_lanthipeptide

TARSYCACYSGENSCGRGCTITTECPFLTFICC

TA SYC CYS ++SCG GCTITTECP T ICC

TANSYCHCYSNKDSCGHGCTITTECPVATVICC

70.6%

NZ_GG666304.1:

Lanthipeptides: HMPREF0077_RS09155_lanthipeptide

TARSYCACYSGENSCGRGCTITTECPFLTFICC

TA ++C CYSG++SCG GCTITTECPF T ICC

TANTHCHCYSGKDSCGHGCTITTECPFATLICC

67.6%

NZ_JADNMH010000005.1:

Lanthipeptides: I2E99_RS07105_lanthipeptide

TARSYCACYSGENSCGRGCTITTECPFLTFICC

TA +YC CYSG++SCGR CTITTECP T +CC

TANTYCHCYSGKDSCGRRCTITTECPIATVVCC

67.6%

NZ_JADPCZ010000011.1and 1 other:

NZ_OW659477.1 Lanthipeptides: NMG62_RS06660_lanthipeptide

Lanthipeptides: I4W03_RS06785_lanthipeptide

TARSYCACYSGENSCGRGCTITTECPFLTFICC

TA +YC CYSG++SCGR CT+TTECP T ICC

TANTYCHCYSGKHSCGRACTVTTECPIATIICC

66.7%

NZ_CP040409.1and 4 others:

NZ_CP040411.1 Lanthipeptides: FE334_RS06825_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS09430_lanthipeptideNZ_JH601103.1 Lanthipeptides: HMPREF9703_RS02710_lanthipeptideNZ_NAQX01000046.1 Lanthipeptides: B8A46_RS06295_lanthipeptide

Lanthipeptides: FE336_RS08590_lanthipeptide

TARSYCACYSGENSCGRGCTITTECPFLTFICC

TA +YC CYSG +SCGR CTIT ECP T CC

TANTYCRCYSGRHSCGRACTITAECPVFTVACC

58.8%

NZ_JAESIP010000017.1and 3 others:

NZ_LT907978.1 Lanthipeptides: EHLA_RS12685_lanthipeptideNZ_QRYY01000029.1 Lanthipeptides: DWW21_RS18370_lanthipeptideNZ_SPFW01000044.1 Lanthipeptides: FGQ81_RS16590_lanthipeptide

Lanthipeptides: JMK14_RS12260_lanthipeptide

TARSYCACYSGENSCGRGCTITTECPFLTFICC

TA ++C CYS + SCGR CT T ECP +T ICC

TANTHCNCYSEDASCGRLCTGTAECPIMTIICC

52.9%

NZ_LMFO01000023.1:

Lanthipeptides: allorf_629531_629758_lanthipeptide

TARSYCACYSGENSCGRGCTITTECPFLTFIC

+ +Y +CYS + SCG CT TTECPFL+F C

SPNTYNSCYSKQKSCGNFCTFTTECPFLSFCC

36.4%

NZ_CP114875.1:

Lanthipeptides: O4Z47_RS14375_lanthipeptide

SGENSCGRGCTITTECPFL-TFICC

+ +NS G CT+T+EC L T++CC

TKKNSSGDICTLTSECDHLATWVCC

33.3%

NZ_AUBN01000022.1:

Lanthipeptides: G448_RS16025_lanthipeptide

SCGRGCTITTECPFLTFIC

S G CT+T EC TFIC

SSGWFCTLTIECG--TFIC

MIBiG 4.0 matches for ADG88_RS11420

18.2%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

GRGCTITTEC

G CT+T EC

GAYCTLTVEC

18.2%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

GRGCTITTEC

G CT+T EC

GGWCTLTKEC

10.3%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

CTITTEC

CT++ EC

CTLSKEC

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.06 out of 19.26

Confidence: strong

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 22.40 out of 22.40

Confidence: strong

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 28.90 out of 29.25

Confidence: strong

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.02 out of 24.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.02 out of 26.06

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 22.35 out of 25.88

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 15.26 out of 18.16

Confidence: strong

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 22.31 out of 25.88

Confidence: medium

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.79 out of 21.84

Confidence: medium

Additional weak hits (1):

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 19.31 out of 27.18

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

ADG88_RS11420 - Class II

Cleavage pHMM score: -1.50

RODEO score: 0

Monoisotopic mass: 3415.4 Da

Molecular weight: 3417.9 Da

Number of bridges: 7

Alternative weights: (assuming N unmodified Ser/Thr residues); 3435.9 Da N = 1

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CRP	Cyclic AMP receptor protein
HypR	L-hydroxyproline utilization repressor
LexA variant 2	Repressor of DNA damage response
MexT	Global virulence regulator
MogR	Repressor of flagellar motility genes
PsrA	Oleic acid responsive regulator
SypG	Regulator of biofilm formation and host colonization
ToxT	Regulator of MSHA biosynthesis