Select genomic region:
Overview
12.1
15.1
25.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_JVCZ01000014.1 (Streptococcus parasanguinis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 12.1 | terpene-precursor | 21,160 | 42,035 |

NZ_JVCZ01000017.1 (Streptococcus parasanguinis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 15.1 | T3PKS | 1 | 36,182 |

NZ_JVCZ01000028.1 (Streptococcus parasanguinis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 25.1 | lanthipeptide-class-ii | 244,658 | 267,909 | Low | thermophilin 1277 | ribosomal:RiPP:Lanthipeptide

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 12.1 | terpene-precursor | 21,160 | 42,035 |
Region 15.1 | T3PKS | 1 | 36,182 |
Region 25.1 | lanthipeptide-class-ii | 244,658 | 267,909 | Low | thermophilin 1277 | ribosomal:RiPP:Lanthipeptide

No secondary metabolite regions were found in these records:
  NZ_JVCZ01000003.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000004.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000005.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000006.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000007.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000008.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000009.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000010.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000011.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000012.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000013.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000015.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000016.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000018.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000020.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000021.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000022.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000023.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000024.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000025.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000026.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000027.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000029.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000030.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000031.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000032.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000033.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000034.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000036.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000037.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000038.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000039.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000040.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000041.1 (Streptococcus parasanguinis)
  NZ_JVCZ01000001.1 (Streptococcus parasanguinis)

Compact view
NZ_JVCZ01000014.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 21,160 - 42,035 nt. (total: 20,876 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Ligases: synthetase
ADG88_RS02405: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002285.2 |  | 0.31 | ribosomal | aborycin | Streptomyces sp. ZS0098
BGC0001456.3 |  | 0.31 | terpene | isorenieratene | Streptomyces argillaceus
BGC0001594.3 |  | 0.29 | other (other) | fischerindole L | Fischerella muscicola UTEX 1829
BGC0000668.5 |  | 0.29 | other (other), terpene | 12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole | Hapalosiphon welwitschii UTEX B 1830
BGC0001756.3 |  | 0.29 | terpene | retigeranin, arathanatriene | Arabidopsis thaliana
BGC0000495.5 |  | 0.28 | ribosomal | actagardine | Actinoplanes garbadinensis
BGC0001126.4 |  | 0.28 | other (other), terpene | 12-epi-hapalindole J isonitrile, ambiguine A isonitrile, ambiguine B isonitrile, ambiguine C isonitrile, ambiguine D isonitrile, ambiguine E isonitrile, ambiguine K isonitrile, ambiguine L isonitrile, ambiguine I isonitrile, ambiguine J isonitrile | Fischerella ambigua UTEX 1903

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002285.2 |  | 0.31 | ribosomal | aborycin | Streptomyces sp. ZS0098
BGC0001456.3 |  | 0.31 | terpene | isorenieratene | Streptomyces argillaceus
BGC0001594.3 |  | 0.29 | other (other) | fischerindole L | Fischerella muscicola UTEX 1829
BGC0000668.5 |  | 0.29 | other (other), terpene | 12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole | Hapalosiphon welwitschii UTEX B 1830
BGC0001756.3 |  | 0.29 | terpene | retigeranin, arathanatriene | Arabidopsis thaliana
BGC0000495.5 |  | 0.28 | ribosomal | actagardine | Actinoplanes garbadinensis
BGC0001126.4 |  | 0.28 | other (other), terpene | 12-epi-hapalindole J isonitrile, ambiguine A isonitrile, ambiguine B isonitrile, ambiguine C isonitrile, ambiguine D isonitrile, ambiguine E isonitrile, ambiguine K isonitrile, ambiguine L isonitrile, ambiguine I isonitrile, ambiguine J isonitrile | Fischerella ambigua UTEX 1903

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
ADG88_RS02405: PT_FPPS_like
Domain 1 (27 - 271): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  IPP, DMAPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.67 out of 20.97
Confidence: medium
Additional weak hits (6):
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.24 out of 25.88
Confidence: weak
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.94 out of 27.55
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 22.66 out of 26.12
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.95 out of 26.06
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 18.92 out of 30.12
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 18.92 out of 30.12
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
ToxT | Regulator of MSHA biosynthesis

NZ_JVCZ01000017.1 - Region 1 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 36,182 nt. (total: 36,182 nt) Show pHMM detection rules used
Region on contig edge.
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: reductase
ADG88_RS03325: hydroxymethylglutaryl-CoA reductase

smcogs
  SMCOG1187: hydroxymethylglutaryl-CoA reductase

Hydrolases: hydrolase
ADG88_RS03290: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

Ligases: synthase
ADG88_RS03330: hydroxymethylglutaryl-CoA synthase

smcogs
  SMCOG1043: hydroxymethylglutaryl-CoA synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002561.3 |  | 0.45 | other (other) | phenazine SA, phenazine SB, phenazine SC | Streptomyces sp.
BGC0000286.3 |  | 0.41 | PKS | viguiepinol | Streptomyces sp. KO-3988
BGC0000205.3 |  | 0.40 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0002703.2 |  | 0.39 | ribosomal | archalan α | Halorussus salinus
BGC0001080.5 |  | 0.39 | other (phenazine) | endophenazine A, endophenazine B | Streptomyces anulatus
BGC0000934.4 |  | 0.37 | other (phenazine) | 5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G | Kitasatospora sp. HKI 714
BGC0000679.5 |  | 0.31 | terpene | diazepinomicin | Micromonospora sp. M42
BGC0001079.5 |  | 0.31 | PKS, terpene | napyradiomycin A80915C, napyradiomycin 2, napyradiomycin 3, napyradiomycin 4 | Streptomyces aculeolatus
BGC0001078.5 |  | 0.30 | PKS, terpene | furaquinocin B | Streptomyces sp. KO-3988
BGC0000872.5 |  | 0.30 | other (other) | A-90289 A, A-90289 B | Streptomyces sp. SANK 60405

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002561.3 |  | 0.45 | other (other) | phenazine SA, phenazine SB, phenazine SC | Streptomyces sp.
BGC0000286.3 |  | 0.41 | PKS | viguiepinol | Streptomyces sp. KO-3988
BGC0000205.3 |  | 0.40 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0002703.2 |  | 0.39 | ribosomal | archalan α | Halorussus salinus
BGC0001080.5 |  | 0.39 | other (phenazine) | endophenazine A, endophenazine B | Streptomyces anulatus
BGC0000934.4 |  | 0.37 | other (phenazine) | 5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G | Kitasatospora sp. HKI 714
BGC0000679.5 |  | 0.31 | terpene | diazepinomicin | Micromonospora sp. M42
BGC0001079.5 |  | 0.31 | PKS, terpene | napyradiomycin A80915C, napyradiomycin 2, napyradiomycin 3, napyradiomycin 4 | Streptomyces aculeolatus
BGC0001078.5 |  | 0.30 | PKS, terpene | furaquinocin B | Streptomyces sp. KO-3988
BGC0000872.5 |  | 0.30 | other (other) | A-90289 A, A-90289 B | Streptomyces sp. SANK 60405

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.11 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.70 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.67 out of 26.06
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.13 out of 20.97
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.02 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.31 out of 26.06
Confidence: medium
Additional weak hits (6):
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.32 out of 30.25
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.45 out of 26.06
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.14 out of 31.73
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.67 out of 30.25
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 26.05 out of 30.97
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.75 out of 26.06
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes

NZ_JVCZ01000028.1 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 244,658 - 267,909 nt. (total: 23,252 nt) Show pHMM detection rules used
Region on contig edge.
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase
ADG88_RS08095: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000504.5 |  | 0.57 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000554.4 |  | 0.56 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001210.5 |  | 0.53 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000558.5 |  | 0.53 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000525.5 |  | 0.51 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000521.3 |  | 0.51 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000626.3 |  | 0.49 | ribosomal | thuricin | Bacillus thuringiensis
BGC0001787.3 |  | 0.49 | ribosomal | suicin 3908 | Streptococcus suis
BGC0000552.3 |  | 0.49 | ribosomal | SmbA, SmbB | Streptococcus mutans
BGC0000539.5 |  | 0.48 | ribosomal | nukacin ISK-1 | Staphylococcus warneri

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000504.5 |  | 0.57 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000554.4 |  | 0.56 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001210.5 |  | 0.53 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000558.5 |  | 0.53 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000525.5 |  | 0.51 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000521.3 |  | 0.51 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000626.3 |  | 0.49 | ribosomal | thuricin | Bacillus thuringiensis
BGC0001787.3 |  | 0.49 | ribosomal | suicin 3908 | Streptococcus suis
BGC0000552.3 |  | 0.49 | ribosomal | SmbA, SmbB | Streptococcus mutans
BGC0000539.5 |  | 0.48 | ribosomal | nukacin ISK-1 | Staphylococcus warneri

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for ADG88_RS08095

ADG88_RS11420
Leader:
MSDWKKPIYESLSTEGNPAGDILRELSDSEMDQTMAGG
Core:
T A R S Y C A C Y S G E N S C G R G C T I T T E C P F L T F I C C
Core with dehydrations:
Dhb A R Dha Y Cys A Cys Y Dha G E N Dha Cys G R G Cys Dhb I Dhb Dhb E Cys P F L Dhb F I Cys Cys

#### antiSMASH-DB 4.0 matches for ADG88_RS11420

100.0%
NZ_JVCZ01000028.1:
Lanthipeptides: ADG88_RS11420_lanthipeptide
1
T A R S Y C A C Y S G E N S C G R G C T I T T E C P F L T F I C C
33
T A R S Y C A C Y S G E N S C G R G C T I T T E C P F L T F I C C
1
T A R S Y C A C Y S G E N S C G R G C T I T T E C P F L T F I C C
33
97.0%
NC_011900.1 and 2 others:
NZ_NCVD01000002.1 Lanthipeptides: B7702_RS00350_lanthipeptide NZ_NCVL01000015.1 Lanthipeptides: B7694_RS04515_lanthipeptide
Lanthipeptides: SPN23F_RS06435_lanthipeptide
1
T A R S Y C A C Y S G E N S C G R G C T I T T E C P F L T F I C C
33
T A R S Y C A C Y S G E+S C G R G C T I T T E C P F L T F I C C
1
T A R S Y C A C Y S G E H S C G R G C T I T T E C P F L T F I C C
33
93.9%
NZ_CP102135.1:
Lanthipeptides: NQZ98_RS01500_lanthipeptide
1
T A R S Y C A C Y S G E N S C G R G C T I T T E C P F L T F I C C
33
T A R S Y C C Y S G E+S C G R G C T I T T E C P F L T F I C C
1
T A R S Y C G C Y S G E H S C G R G C T I T T E C P F L T F I C C
33
with 53 more sequence matches
Only the first 10 are displayed here.
76.5%
NZ_LR595858.1:
Lanthipeptides: FQT45_RS03330_lanthipeptide
1
T A R S Y C A C Y S G E N S C G R G C T I T T E C P F L T F I C C
33
T A S Y C C Y S G++S C G R G C T I T T E C P T I C C
2
T A N S Y C H C Y S G K D S C G R G C T I T T E C P I A T I I C C
34
72.7%
NZ_FQTY01000002.1:
Lanthipeptides: BUB33_RS04605_lanthipeptide
1
T A R S Y C A C Y S G E N S C G R G C T I T T E C P F L T F I C C
33
T A S Y C C Y S ++S C G G C T I T T E C P T I C C
1
T A N S Y C H C Y S N K D S C G H G C T I T T E C P V A T V I C C
33
70.6%
NZ_GG666304.1:
Lanthipeptides: HMPREF0077_RS09155_lanthipeptide
1
T A R S Y C A C Y S G E N S C G R G C T I T T E C P F L T F I C C
33
T A ++C C Y S G++S C G G C T I T T E C P F T I C C
2
T A N T H C H C Y S G K D S C G H G C T I T T E C P F A T L I C C
34
67.6%
NZ_JADNMH010000005.1:
Lanthipeptides: I2E99_RS07105_lanthipeptide
1
T A R S Y C A C Y S G E N S C G R G C T I T T E C P F L T F I C C
33
T A +Y C C Y S G++S C G R C T I T T E C P T +C C
2
T A N T Y C H C Y S G K D S C G R R C T I T T E C P I A T V V C C
34
67.6%
NZ_JADPCZ010000011.1 and 1 other:
NZ_OW659477.1 Lanthipeptides: NMG62_RS06660_lanthipeptide
Lanthipeptides: I4W03_RS06785_lanthipeptide
1
T A R S Y C A C Y S G E N S C G R G C T I T T E C P F L T F I C C
33
T A +Y C C Y S G++S C G R C T+T T E C P T I C C
2
T A N T Y C H C Y S G K H S C G R A C T V T T E C P I A T I I C C
34
66.7%
NZ_CP040409.1 and 4 others:
NZ_CP040411.1 Lanthipeptides: FE334_RS06825_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS09430_lanthipeptide NZ_JH601103.1 Lanthipeptides: HMPREF9703_RS02710_lanthipeptide NZ_NAQX01000046.1 Lanthipeptides: B8A46_RS06295_lanthipeptide
Lanthipeptides: FE336_RS08590_lanthipeptide
1
T A R S Y C A C Y S G E N S C G R G C T I T T E C P F L T F I C C
33
T A +Y C C Y S G +S C G R C T I T E C P T C C
1
T A N T Y C R C Y S G R H S C G R A C T I T A E C P V F T V A C C
33
58.8%
NZ_JAESIP010000017.1 and 3 others:
NZ_LT907978.1 Lanthipeptides: EHLA_RS12685_lanthipeptide NZ_QRYY01000029.1 Lanthipeptides: DWW21_RS18370_lanthipeptide NZ_SPFW01000044.1 Lanthipeptides: FGQ81_RS16590_lanthipeptide
Lanthipeptides: JMK14_RS12260_lanthipeptide
1
T A R S Y C A C Y S G E N S C G R G C T I T T E C P F L T F I C C
33
T A ++C C Y S + S C G R C T T E C P +T I C C
2
T A N T H C N C Y S E D A S C G R L C T G T A E C P I M T I I C C
34
52.9%
NZ_LMFO01000023.1:
Lanthipeptides: allorf_629531_629758_lanthipeptide
1
T A R S Y C A C Y S G E N S C G R G C T I T T E C P F L T F I C
32
+ +Y +C Y S + S C G C T T T E C P F L+F C
3
S P N T Y N S C Y S K Q K S C G N F C T F T T E C P F L S F C C
34
36.4%
NZ_CP114875.1:
Lanthipeptides: O4Z47_RS14375_lanthipeptide
10
S G E N S C G R G C T I T T E C P F L-T F I C C
33
+ +N S G C T+T+E C L T++C C
3
T K K N S S G D I C T L T S E C D H L A T W V C C
27
33.3%
NZ_AUBN01000022.1:
Lanthipeptides: G448_RS16025_lanthipeptide
14
S C G R G C T I T T E C P F L T F I C
32
S G C T+T E C T F I C
2
S S G W F C T L T I E C G--T F I C
18

#### MIBiG 4.0 matches for ADG88_RS11420

18.2%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
16
G R G C T I T T E C
25
G C T+T E C
14
G A Y C T L T V E C
23
18.2%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
16
G R G C T I T T E C
25
G C T+T E C
16
G G W C T L T K E C
25
10.3%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
19
C T I T T E C
25
C T++ E C
28
C T L S K E C
34

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.06 out of 19.26
Confidence: strong
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 22.40 out of 22.40
Confidence: strong
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 28.90 out of 29.25
Confidence: strong
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.02 out of 24.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.02 out of 26.06
Confidence: medium
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 22.35 out of 25.88
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 15.26 out of 18.16
Confidence: strong
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 22.31 out of 25.88
Confidence: medium
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.79 out of 21.84
Confidence: medium
Additional weak hits (1):
NrdR
Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 19.31 out of 27.18
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

ADG88_RS11420 - Class II
  Cleavage pHMM score: -1.50
  RODEO score: 0
  Monoisotopic mass: 3415.4 Da
  Molecular weight: 3417.9 Da
  Number of bridges: 7
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3435.9 Da N = 1

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CRP | Cyclic AMP receptor protein
HypR | L-hydroxyproline utilization repressor
LexA variant 2 | Repressor of DNA damage response
MexT | Global virulence regulator
MogR | Repressor of flagellar motility genes
PsrA | Oleic acid responsive regulator
SypG | Regulator of biofilm formation and host colonization
ToxT | Regulator of MSHA biosynthesis