GCF_000393015.1 - 4 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_KB944666.1 (Enterococcus faecalis EnGen0336)

Region	Type	From	To
Region 1.1	lanthipeptide-class-ii	90,666	113,650
Region 1.2	RiPP-like	814,354	825,397
Region 1.3	terpene-precursor	1,089,879	1,110,760
Region 1.4	cyclic-lactone-autoinducer	1,875,595	1,896,323

Region	Type	From	To	Most similar known cluster
Region 1.1	lanthipeptide-class-ii	90,666	113,650
Region 1.2	RiPP-like	814,354	825,397
Region 1.3	terpene-precursor	1,089,879	1,110,760
Region 1.4	cyclic-lactone-autoinducer	1,875,595	1,896,323

No secondary metabolite regions were found in these records:: NZ_KB944667.1 (Enterococcus faecalis EnGen0336); NZ_KB944668.1 (Enterococcus faecalis EnGen0336)

Compact view

NZ_KB944666.1 - Region 1 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 90,666 - 113,650 nt. (total: 22,985 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: deacetylase

WMS_RS03585: acetylornithine deacetylase

smcogs: SMCOG1247: acetylornithine deacetylase

Lyases: cyclase

WMS_RS03540: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.56	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.5	0.51	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000516.4	0.49	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000527.5	0.49	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000623.3	0.48	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000558.5	0.48	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000521.3	0.48	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0002698.2	0.46	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000626.3	0.45	ribosomal	thuricin	Bacillus thuringiensis
BGC0001210.5	0.45	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.56	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.5	0.51	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000516.4	0.49	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000527.5	0.49	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000623.3	0.48	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000558.5	0.48	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000521.3	0.48	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0002698.2	0.46	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000626.3	0.45	ribosomal	thuricin	Bacillus thuringiensis
BGC0001210.5	0.45	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for WMS_RS03540

WMS_RS03545

Leader:

MDEKQLDSLVGQKFEDLSKEEMNFIAGG

Core:

NDNARISPTIILSAATVASAASSFVGSYTLSAFTKCR

Core with dehydrations:

NDNARIDhaPDhbIILDhaAADhbVADhaAADhaDhaFVGDhaYDhbLDhaAFDhbKCysR

antiSMASH-DB 4.0 matches for WMS_RS03545

100.0%

NC_021023.1and 9 others:

NZ_CABGJL010000002.1 Lanthipeptides: FN048_RS03095_lanthipeptideNZ_CABGPX010000017.1 Lanthipeptides: FN189_RS10935_lanthipeptideNZ_CABGTR010000003.1 Lanthipeptides: FN307_RS09565_lanthipeptideNZ_CP097048.1 Lanthipeptides: M2906_RS12940_lanthipeptideNZ_CP116962.1 Lanthipeptides: PO880_RS01555_lanthipeptideNZ_GG670379.1 Lanthipeptides: EFDG_RS12825_lanthipeptideNZ_GL454198.1 Lanthipeptides: HMPREF9500_RS14725_lanthipeptideNZ_KB944666.1 Lanthipeptides: WMS_RS03545_lanthipeptideNZ_KZ845971.1 Lanthipeptides: EB55_RS12315_lanthipeptide

Lanthipeptides: ENT_RS13920_lanthipeptide

NDNARISPTIILSAATVASAASSFVGSYTLSAFTKCR

97.3%

NZ_JTKS01000015.1:

Lanthipeptides: QI17_RS10285_lanthipeptide

NDNARISPTIILSAATVASAASSFVGSYTLSAFTKCR

NDNARISP IILSAATVASAASSFVGSYTLSAFTKCR

NDNARISPKIILSAATVASAASSFVGSYTLSAFTKCR

43.2%

NZ_CP044545.1:

Lanthipeptides: F7984_RS17855_lanthipeptide

NARISPTIILSAATVASAASSFVGSYTLSA

N I P AATV SA +SFVGSY ++A

NGEIQPQGT-PAATVISALASFVGSYLVTA

with 20 more sequence matches

Only the first 10 are displayed here.

37.8%

NZ_JACSNF010000005.1and 1 other:

NZ_LMPR01000013.1 Lanthipeptides: ASF99_RS16385_lanthipeptide

Lanthipeptides: KNQ12_RS14670_lanthipeptide

SPTIILSAATVASAASSFVGSYTLSAFTKC

S + + ++ V SA SFVGSY SA KC

STDVDVRSSLVCSALLSFVGSYLASAGLKC

34.0%

NZ_CP099547.1:

Lanthipeptides: allorf_0559994_0560212_lanthipeptide

SPTIILSA---ATVASAASSFVGSYTL----SAFTKCR

+PT+ S+ ATV+ A S + S+T+ SA+TKCR

TPTVTTSSVPCATVSKAVSGALVSWTVSFVASAWTKCR

32.4%

NZ_NVMQ01000017.1:

Lanthipeptides: CON32_RS17790_lanthipeptide

NARISPTIILSAATVASAASSFVGSYTLSAFTKC

+ R +P+ +L+ SFV SY SA KC

DPRTTPSPLLA---------SFVASYIASAEFKC

29.7%

NZ_FNYB01000021.1:

Lanthipeptides: BMZ34_RS24355_lanthipeptide

NARISPTIILSAATVASAASSFVGSYTLSAFTKC

+ R +P+ +L+ SFV SY SA +C

DPRTTPSPLLA---------SFVASYIASAEFRC

29.7%

NZ_FNYB01000021.1:

Lanthipeptides: BMZ34_RS24360_lanthipeptide

NARISPTIILSAATVASAASSFVGSYTLSAFTKC

+ R +P+ +L+ SFV SY SA +C

DPRTTPSPLLA---------SFVASYIASAQYRC

29.7%

NZ_KB976303.1:

Lanthipeptides: IGY_RS26050_lanthipeptide

NARISPTIILSAATVASAASSFVGSYTLSAFTKC

+ R +P+ +L+ SFV SY SA +C

DPRTTPSPLLA---------SFVASYIASAQFRC

29.7%

NZ_LT800494.1:

Lanthipeptides: B7E07_RS02625_lanthipeptide

NARISPTIILSAATVASAASSFVGSYTLSA

+ +PTI L++A V + S+F S T++A

EPQATPTIALTSALVGAPVSAF-ASLTITA

29.7%

NZ_NAOJ01000022.1:

Lanthipeptides: B5K31_RS08015_lanthipeptide

TVASAASSFVGSYTLSAFTKC

T+ SA SF+ SY SA T+C

TICSATLSFIASYLGSAQTRC

27.0%

NC_003028.3and 46 others:

NC_003098.1 Lanthipeptides: SPR_RS08865_lanthipeptideNC_011900.1 Lanthipeptides: SPN23F_RS10050_lanthipeptideNC_012466.1 Lanthipeptides: SPJ_RS09635_lanthipeptideNZ_CFDV01000030.1 Lanthipeptides: AQB43_RS08320_lanthipeptideNZ_CFVJ01000005.1 Lanthipeptides: AP598_RS03265_lanthipeptideNZ_CGGJ01000006.1 Lanthipeptides: AP607_RS03205_lanthipeptideNZ_CHVQ01000007.1 Lanthipeptides: AQF85_RS04285_lanthipeptideNZ_CJZM01000008.1 Lanthipeptides: AEE29_RS04155_lanthipeptideNZ_CLHL01000007.1 Lanthipeptides: AE723_RS05750_lanthipeptideNZ_CMIW01000004.1 Lanthipeptides: AD046_RS04075_lanthipeptideNZ_CMKL01000017.1 Lanthipeptides: AD734_RS09110_lanthipeptideNZ_CP035244.1 Lanthipeptides: EQH36_RS09105_lanthipeptideNZ_CP035253.1 Lanthipeptides: EQH27_RS09740_lanthipeptideNZ_CP082820.1 Lanthipeptides: K8B76_RS08865_lanthipeptideNZ_CPPE01000023.1 Lanthipeptides: AD654_RS06875_lanthipeptideNZ_CPRX01000013.1 Lanthipeptides: AEE77_RS05820_lanthipeptideNZ_CPTT01000011.1 Lanthipeptides: AEH42_RS06000_lanthipeptideNZ_CRAW01000006.1 Lanthipeptides: AK725_RS04395_lanthipeptideNZ_CRXO01000010.1 Lanthipeptides: AKU38_RS05260_lanthipeptideNZ_FCRW01000008.1 Lanthipeptides: A1N73_RS07425_lanthipeptideNZ_FDDE01000015.1 Lanthipeptides: A1A23_RS09705_lanthipeptideNZ_FDFR01000008.1 Lanthipeptides: A1O50_RS09320_lanthipeptideNZ_FDGF01000009.1 Lanthipeptides: A0899_RS06595_lanthipeptideNZ_FDQP01000009.1 Lanthipeptides: A1S42_RS08050_lanthipeptideNZ_FECM01000008.1 Lanthipeptides: A1930_RS06475_lanthipeptideNZ_FEEQ01000001.1 Lanthipeptides: A1T31_RS01145_lanthipeptideNZ_FEOS01000003.1 Lanthipeptides: A1178_RS03085_lanthipeptideNZ_FFTU01000009.1 Lanthipeptides: A1K37_RS06335_lanthipeptideNZ_FHJP02000011.1 Lanthipeptides: A1O79_RS07375_lanthipeptideNZ_FHRS02000028.1 Lanthipeptides: A1898_RS09820_lanthipeptideNZ_FIXQ01000010.1 Lanthipeptides: AZ721_RS04790_lanthipeptideNZ_FZDX01000018.1 Lanthipeptides: CFW91_RS09480_lanthipeptideNZ_FZEI01000008.1 Lanthipeptides: CFW58_RS06410_lanthipeptideNZ_JACVHZ010000010.1 Lanthipeptides: ICJ99_RS03880_lanthipeptideNZ_JAGFAE010000038.1 Lanthipeptides: J5E60_RS09005_lanthipeptideNZ_JALDUX010000010.1 Lanthipeptides: M1F92_RS09535_lanthipeptideNZ_JAMYJM010000002.1 Lanthipeptides: NKE69_RS04885_lanthipeptideNZ_LR216014.1 Lanthipeptides: E0F05_RS09385_lanthipeptideNZ_LR216016.1 Lanthipeptides: E0F10_RS10160_lanthipeptideNZ_LR216019.1 Lanthipeptides: E0E94_RS09635_lanthipeptideNZ_LR216027.1 Lanthipeptides: E0E81_RS09205_lanthipeptideNZ_LR216049.1 Lanthipeptides: E0E96_RS09540_lanthipeptideNZ_LR216064.1 Lanthipeptides: E0F31_RS09525_lanthipeptideNZ_LR536843.1 Lanthipeptides: E0F34_RS09600_lanthipeptideNZ_MRXY01000010.1 Lanthipeptides: BTU63_RS06305_lanthipeptideNZ_NANQ01000003.1 Lanthipeptides: B5K28_RS01935_lanthipeptide

Lanthipeptides: SP_RS09795_lanthipeptide

VASAASSFVGSYTLSAFTKC

+ SA SF+ SY SA T+C

ICSATLSFIASYLGSAQTRC

27.0%

NZ_CP041405.1:

Lanthipeptides: FLT43_RS14405_lanthipeptide

VASAASSFVGSYTLSAFTKC

V A S+V SY SA KC

VCGAGISYVASYLASAAFKC

WMS_RS03550

Leader:

MEAEKIVGM

Core:

QFEDLSKEEMNFIAGGNNNARISPTIVTPVTPYTSYVASAAGSAALSAVSGLVSYTKKCF

Core with dehydrations:

QFEDLDhaKEEMNFIAGGNNNARIDhaPDhbIVDhbPVDhbPYDhbDhaYVADhaAAGDhaAALDhaAVDhaGLVDhaYDhbKKCysF

antiSMASH-DB 4.0 matches for WMS_RS03550

100.0%

NC_021023.1and 10 others:

NZ_CABGJL010000002.1 Lanthipeptides: FN048_RS03100_lanthipeptideNZ_CABGPX010000017.1 Lanthipeptides: FN189_RS10930_lanthipeptideNZ_CABGTR010000003.1 Lanthipeptides: FN307_RS09560_lanthipeptideNZ_CP097048.1 Lanthipeptides: M2906_RS12945_lanthipeptideNZ_CP116962.1 Lanthipeptides: PO880_RS01550_lanthipeptideNZ_GG670379.1 Lanthipeptides: EFDG_RS12820_lanthipeptideNZ_GL454198.1 Lanthipeptides: HMPREF9500_RS14730_lanthipeptideNZ_JTKS01000015.1 Lanthipeptides: QI17_RS10290_lanthipeptideNZ_KB944666.1 Lanthipeptides: WMS_RS03550_lanthipeptideNZ_KZ845971.1 Lanthipeptides: EB55_RS12320_lanthipeptide

Lanthipeptides: ENT_RS13925_lanthipeptide

QFEDLSKEEMNFIAGGNNNARISPTIVTPVTPYTSYVASAAGSAALSAVSGLVSYTKKCF

35.0%

NZ_GG730336.1:

Lanthipeptides: SAUG_RS08755_lanthipeptide

GNNNARISPTIVTPVTPYTSYVASAAGSAALSAVSGLVSYTKKCF

G + +PTI +P TPY ++ A +SAVSGLVSYTK C

GTVEPQATPTIASPFTPYAIEISIGA---TVSAVSGLVSYTKDCL

30.0%

NZ_FPCC01000026.1:

Lanthipeptides: BM377_RS12905_lanthipeptide

FEDLSKEEMNFIAG-GNNNARISPTIVTPVTPYTSYVASAAGSAALSAVS

FEDL+ E+M G G+ +A +P I+ P S A + ALS +S

FEDLNTEDMQNTQGAGDVDAETTPVIM----PICSPSAVVNPTLALSLIS

with 25 more sequence matches

Only the first 10 are displayed here.

28.3%

NZ_FPCC01000026.1:

Lanthipeptides: BM377_RS12900_lanthipeptide

FEDLSKEEM-NFIAGGNNNARISPTI--VTPVTPYTS

FEDL+ E+M N GG+ NA TI +T V P S

FEDLNTEDMQNTQGGGDVNAETIVTISNLTLVGPIVS

28.3%

NZ_JACSPZ010000014.1:

Lanthipeptides: H9635_RS18390_lanthipeptide

VTPYTSYVASAAGSA------ALSAVSGLVSYTKKCF

V P+T+ + SAA + A+SA+SGLVSY K C

VEPHTTPILSAATKSSKKCLGAISAISGLVSYNKDCL

27.4%

NZ_CP011152.1and 1 other:

NZ_CP011152.1 Lanthipeptides: WR47_RS28810_lanthipeptide

Lanthipeptides: WR47_RS28810_lanthipeptide

FEDLSKEEM-NFIAGGNNNARISPT-IVTPVTPYTSYVASAAGSAALSAVSGLVSYTKKC

E++ E+ N + G+ A S I+TP TP S G A + TK+C

LEEIQGNELLNAVGAGDVQANTSTVQILTPRTPIISNTLGNKGHAC--------TITKEC

26.7%

NC_021023.1and 9 others:

Lanthipeptides: ENT_RS13920_lanthipeptide

NNNARISPTIVTPVTPYTSYVASAAGSAALSAVS

N+NARISPTI+ S +S GS LSA +

NDNARISPTIILSAATVASAASSFVGSYTLSAFT

26.7%

NZ_BMSZ01000006.1and 4 others:

NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12790_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS18195_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptide

Lanthipeptides: IE135_RS12790_lanthipeptide

ARISPTIVTPVTPYTSYVASAAGSAALSAVSGLVSYTKKC

A I+PTIV P T T+ + A SAA+ TK+C

AGITPTIV-PATAVTTVIVGA--SAAMQGGCPTSGCTKRC

26.7%

NZ_CP026035.1:

Lanthipeptides: C2H96_RS00305_lanthipeptide

TPYTSYVASAAG-------SAALSAVSGLVSYTKKCF

TP S V SA G S SA+SG+VS+ K C

TPAVSAVLSAVGRSTRLCISGIGSAISGIVSHNKDCL

26.7%

NZ_FPCC01000026.1:

Lanthipeptides: BM377_RS12915_lanthipeptide

FEDLSKEEMNFIAGGNNNARISPTIVTPVTPYTSYVASAAGSAALSAVSGLVSYTKKCF

+EDL+ E+M G + + T+ +T A S +SG +S KKC

YEDLNTEDMQNTQGAGDTE--AETVSLAIT-----------GAIASVISGAISL-KKCV

26.7%

NZ_KN125582.1:

Lanthipeptides: DJ91_RS27550_lanthipeptide

NARISPTIVTPVTPYTSYVASAAGSAALSAVSGLVSYTKKCF

+ R PT++ S ++SA ++ +SA+SGLVSY K C

DTRTHPTVIV-----VSRISSAKCASTISAISGLVSYNKDCL

25.0%

NZ_CP011152.1and 3 others:

NZ_CP011152.1 Lanthipeptides: WR47_RS28830_lanthipeptideNZ_CP011152.1 Lanthipeptides: WR47_RS28835_lanthipeptideNZ_CP011152.1 Lanthipeptides: WR47_RS28830_lanthipeptide

Lanthipeptides: WR47_RS28835_lanthipeptide

VTP-VTPYTSYVASAAGSAALSAVSGLVSYTKKC

VTP TP + +A+AAG A +SAV + + KC

VTPQATPTVTILATAAGGAVISAVLPTLKCSSKC

25.0%

NZ_CP094446.1:

Lanthipeptides: L3476_RS23825_lanthipeptide

TIVTPVTPYTSYVASAAGSAALSAVSGLVSYTKKCF

TIV+ VT + SA GSA +SG++S+ K C

TIVSAVTRSSKPCISAIGSA----ISGIISHNKDCL

MIBiG 4.0 matches for WMS_RS03550

11.7%

BGC0002130.3 (QKI29070.1):

Lanthipeptide: cacaoidin

PVTPYTSYVASAAGSAAL

P T Y S AS + +A+

PCTIYASVSASISATASW

6.7%

BGC0000582.4 (ADR72962.1):

Linaridin: cypemycin

TPVTP

TP TP

TPATP

allorf_0096922_0097065

Leader:

MLLLIKTYNYLHSYFILKKYGPVNTSLVHIGGA

Core:

PRNICTENSDSDYL

Core with dehydrations:

PRNICysDhbENDhaDDhaDYL

antiSMASH-DB 4.0 matches for allorf_0096922_0097065

100.0%

NC_021023.1and 9 others:

NZ_CABGJL010000002.1 Lanthipeptides: allorf_195639_195782_lanthipeptideNZ_CABGPX010000017.1 Lanthipeptides: allorf_61913_62056_lanthipeptideNZ_CABGTR010000003.1 Lanthipeptides: allorf_127304_127447_lanthipeptideNZ_CP097048.1 Lanthipeptides: allorf_2681863_2682006_lanthipeptideNZ_CP116962.1 Lanthipeptides: allorf_0340612_0340755_lanthipeptideNZ_GL454198.1 Lanthipeptides: allorf_096858_097001_lanthipeptideNZ_JTKS01000015.1 Lanthipeptides: allorf_208570_208713_lanthipeptideNZ_KB944666.1 Lanthipeptides: allorf_0096922_0097065_lanthipeptideNZ_KZ845971.1 Lanthipeptides: allorf_2372960_2373103_lanthipeptide

Lanthipeptides: allorf_2915554_2915697_lanthipeptide

PRNICTENSDSDYL

22.2%

NZ_CP114875.1:

Lanthipeptides: O4Z47_RS14375_lanthipeptide

NICTENSDSDYL

+ICT S+ D+L

DICTLTSECDHL

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.00 out of 20.47

Confidence: strong

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 22.72 out of 24.78

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.16 out of 26.06

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.36 out of 26.06

Confidence: medium

Additional weak hits (2):

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 24.35 out of 33.73

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.58 out of 29.65

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

WMS_RS03545 - Class II

Cleavage pHMM score: -0.50

RODEO score: 0

Monoisotopic mass: 3591.9 Da

Molecular weight: 3594.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3612.0 Da N = 1; 3630.1 Da N = 2; 3648.1 Da N = 3; 3666.1 Da N = 4; 3684.1 Da N = 5; 3702.1 Da N = 6; 3720.2 Da N = 7; 3738.2 Da N = 8; 3756.2 Da N = 9; 3774.2 Da N = 10

WMS_RS03550 - Class II

Cleavage pHMM score: 1.60

RODEO score: 0

Monoisotopic mass: 6038.1 Da

Molecular weight: 6041.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 6059.7 Da N = 1; 6077.8 Da N = 2; 6095.8 Da N = 3; 6113.8 Da N = 4; 6131.8 Da N = 5; 6149.8 Da N = 6; 6167.9 Da N = 7; 6185.9 Da N = 8; 6203.9 Da N = 9; 6221.9 Da N = 10; 6239.9 Da N = 11; 6258.0 Da N = 12

allorf_0096922_0097065 - Class II

Cleavage pHMM score: -4.70

RODEO score: 0

Monoisotopic mass: 1571.7 Da

Molecular weight: 1572.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1590.7 Da N = 1; 1608.7 Da N = 2

TFBS definitions

Regulator	Description
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
VqsM	Regulator of quorum-sensing signalling systems

NZ_KB944666.1 - Region 2 - RiPP-like

Download region GenBank file

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Location: 814,354 - 825,397 nt. (total: 11,044 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acetyltransferase

WMS_RS06970: Chloramphenicol acetyltransferase

smcogs: SMCOG1156: Chloramphenicol acetyltransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001510.5	0.31	other (other)	anisomycin	Streptomyces hygrospinosus
BGC0002254.3	0.31	PKS	notoamide F, (+)-semivioxanthin, waikikiamide B, waikikiamide C, notoamide A, waikikiamide A	Aspergillus sp. FM242
BGC0000770.4	0.31	saccharide	lipo-oligosaccharide	Campylobacter jejuni
BGC0000762.3	0.27	saccharide	exopolysaccharide	Rhizobium leguminosarum bv. viciae
BGC0001580.3	0.26	PKS	ebelactone	Kitasatospora aburaviensis
BGC0000806.5	0.26	saccharide	phosphonoglycans	Glycomyces sp. NRRL B-16210
BGC0000298.5	0.25	NRPS	aeruginosin 98-A, aeruginosin 98-B, aeruginosin 98-C	Microcystis aeruginosa NIES-98
BGC0000758.4	0.24	saccharide	capsular polysaccharide	Staphylococcus aureus
BGC0001412.3	0.24	saccharide	polysaccharide C	Bacteroides fragilis
BGC0002550.2	0.21	PKS	lobophorin CR4	Streptomyces olivaceus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001510.5	0.31	other (other)	anisomycin	Streptomyces hygrospinosus
BGC0002254.3	0.31	PKS	notoamide F, (+)-semivioxanthin, waikikiamide B, waikikiamide C, notoamide A, waikikiamide A	Aspergillus sp. FM242
BGC0000770.4	0.31	saccharide	lipo-oligosaccharide	Campylobacter jejuni
BGC0000762.3	0.27	saccharide	exopolysaccharide	Rhizobium leguminosarum bv. viciae
BGC0001580.3	0.26	PKS	ebelactone	Kitasatospora aburaviensis
BGC0000806.5	0.26	saccharide	phosphonoglycans	Glycomyces sp. NRRL B-16210
BGC0000298.5	0.25	NRPS	aeruginosin 98-A, aeruginosin 98-B, aeruginosin 98-C	Microcystis aeruginosa NIES-98
BGC0000758.4	0.24	saccharide	capsular polysaccharide	Staphylococcus aureus
BGC0001412.3	0.24	saccharide	polysaccharide C	Bacteroides fragilis
BGC0002550.2	0.21	PKS	lobophorin CR4	Streptomyces olivaceus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05

Confidence: medium

Additional weak hits (1):

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.02 out of 24.78

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production

NZ_KB944666.1 - Region 3 - terpene-precursor

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Location: 1,089,879 - 1,110,760 nt. (total: 20,882 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: peptidase

WMS_RS08380: methionine aminopeptidase

smcogs: SMCOG1172: methionine aminopeptidase

Ligases: synthetase

WMS_RS08415: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002309.2	0.36	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000639.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0001605.3	0.32	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001075.5	0.31	PKS, terpene	aurachin RE	Rhodococcus erythropolis
BGC0001456.3	0.30	terpene	isorenieratene	Streptomyces argillaceus
BGC0000286.3	0.30	PKS	viguiepinol	Streptomyces sp. KO-3988

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002309.2	0.36	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000639.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0001605.3	0.32	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001075.5	0.31	PKS, terpene	aurachin RE	Rhodococcus erythropolis
BGC0001456.3	0.30	terpene	isorenieratene	Streptomyces argillaceus
BGC0000286.3	0.30	PKS	viguiepinol	Streptomyces sp. KO-3988

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

WMS_RS08415: PT_FPPS_like

Domain 1 (29 - 276): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.38 out of 27.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.87 out of 28.19

Confidence: medium

Additional weak hits (1):

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.47 out of 33.14

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ZuR variant 1	Zinc-responsive repressor

NZ_KB944666.1 - Region 4 - cyclic-lactone-autoinducer

Download region GenBank file

Download region SVG

Location: 1,875,595 - 1,896,323 nt. (total: 20,729 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001291.3	0.41	ribosomal	enterocin NKR-5-3B	Enterococcus faecium
BGC0001948.3	0.37	other (other)	naseseazine C, C3-aryl pyrroloindolines	Streptomyces sp.
BGC0000046.4	0.35	PKS	depudecin	Alternaria brassicicola
BGC0002227.3	0.31	NRPS	AKML B, AKML D, AKML A, AKML C	Aspergillus luchuensis IFO 4308
BGC0002667.2	0.30	ribosomal	estericin A	Clostridium estertheticum
BGC0001246.3	0.30	PKS	trans-resorcylide	Sarocladium zeae
BGC0000688.4	0.29	terpene	copalyl diphosphate	Diaporthe amygdali
BGC0001954.2	0.28	NRPS, PKS	wortmanamide A, wortmanamide B	Talaromyces wortmannii
BGC0001366.5	0.27	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0002058.3	0.27	NRPS, PKS	mutanocyclin	Streptococcus mutans B04Sm5

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001291.3	0.41	ribosomal	enterocin NKR-5-3B	Enterococcus faecium
BGC0001948.3	0.37	other (other)	naseseazine C, C3-aryl pyrroloindolines	Streptomyces sp.
BGC0000046.4	0.35	PKS	depudecin	Alternaria brassicicola
BGC0002227.3	0.31	NRPS	AKML B, AKML D, AKML A, AKML C	Aspergillus luchuensis IFO 4308
BGC0002667.2	0.30	ribosomal	estericin A	Clostridium estertheticum
BGC0001246.3	0.30	PKS	trans-resorcylide	Sarocladium zeae
BGC0000688.4	0.29	terpene	copalyl diphosphate	Diaporthe amygdali
BGC0001954.2	0.28	NRPS, PKS	wortmanamide A, wortmanamide B	Talaromyces wortmannii
BGC0001366.5	0.27	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0002058.3	0.27	NRPS, PKS	mutanocyclin	Streptococcus mutans B04Sm5

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 28.99 out of 30.25

Confidence: strong

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.08 out of 23.79

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.50 out of 23.79

Confidence: medium

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
ColR	Phenol-responsive regulator
IolR	Regulator of the inositol catabolism