GCF_000158635.1 - 6 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_EQ973330.1 (Corynebacterium matruchotii ATCC 33806)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 6.1	lanthipeptide-class-ii	432,414	455,014

NZ_EQ973329.1 (Corynebacterium matruchotii ATCC 33806)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 7.1	terpene-precursor	846,353	867,442

NZ_EQ973328.1 (Corynebacterium matruchotii ATCC 33806)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 8.1	NI-siderophore	96,755	127,511
Region 8.2	NRP-metallophore,NRPS	350,467	399,965	Low	aminochelin/azotochelin/protochelin	NRPS:Type I
Region 8.3	terpene	576,248	597,117	Low	carotenoid	terpene
Region 8.4	NRPS,NRPS-like	723,099	770,261

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 6.1	lanthipeptide-class-ii	432,414	455,014
Region 7.1	terpene-precursor	846,353	867,442
Region 8.1	NI-siderophore	96,755	127,511
Region 8.2	NRP-metallophore,NRPS	350,467	399,965	Low	aminochelin/azotochelin/protochelin	NRPS:Type I
Region 8.3	terpene	576,248	597,117	Low	carotenoid	terpene
Region 8.4	NRPS,NRPS-like	723,099	770,261

No secondary metabolite regions were found in these records:: NZ_EQ973335.1 (Corynebacterium matruchotii ATCC 33806); NZ_EQ973334.1 (Corynebacterium matruchotii ATCC 33806); NZ_EQ973333.1 (Corynebacterium matruchotii ATCC 33806); NZ_EQ973332.1 (Corynebacterium matruchotii ATCC 33806); NZ_EQ973331.1 (Corynebacterium matruchotii ATCC 33806)

Compact view

NZ_EQ973330.1 - Region 1 - lanthipeptide-class-ii

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Location: 432,414 - 455,014 nt. (total: 22,601 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

CORMATOL_RS10570: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

CORMATOL_RS10590: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000525.5	0.60	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0002005.2	0.51	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0000517.4	0.51	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0001210.5	0.49	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000626.3	0.48	ribosomal	thuricin	Bacillus thuringiensis
BGC0000539.5	0.48	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0002110.3	0.47	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0001391.3	0.47	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000521.3	0.46	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0001311.5	0.46	ribosomal	flavecins	Ruminococcus flavefaciens FD-1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000525.5	0.60	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0002005.2	0.51	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0000517.4	0.51	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0001210.5	0.49	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000626.3	0.48	ribosomal	thuricin	Bacillus thuringiensis
BGC0000539.5	0.48	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0002110.3	0.47	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0001391.3	0.47	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000521.3	0.46	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0001311.5	0.46	ribosomal	flavecins	Ruminococcus flavefaciens FD-1

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for CORMATOL_RS10570

CORMATOL_RS10555

Leader:

MVCHLDQLLAEREMTLAA

Core:

LADQVGVTVANLSVLKNNRAKAVRFTTLVALCDALDCQPGDLFTAE

Core with dehydrations:

LADQVGVDhbVANLDhaVLKNNRAKAVRFDhbDhbLVALCysDALDCysQPGDLFDhbAE

antiSMASH-DB 4.0 matches for CORMATOL_RS10555

100.0%

NZ_EQ973330.1and 2 others:

NZ_LR134504.1 Lanthipeptides: EL293_RS07235_lanthipeptideNZ_LR134504.1 Lanthipeptides: EL293_RS07235_lanthipeptide

Lanthipeptides: CORMATOL_RS10555_lanthipeptide

LADQVGVTVANLSVLKNNRAKAVRFTTLVALCDALDCQPGDLFTAE

28.3%

NZ_BBZK01000004.1:

Lanthipeptides: BGP73_RS05180_lanthipeptide

TLVALCDALDCQPGDLFT

TL A+C LDCQPGDL T

TLSAICRELDCQPGDLLT

26.5%

NZ_SBIS02000007.1:

Lanthipeptides: EPL00_RS13710_lanthipeptide

VGVTVANLSVLKNNRAKAVRFTTLVALCDALDCQPGDLFTAE

VGVT ++ ++ R L D DC+ DLF E

VGVTRQTINAIERERYDP-SIELAFKLADHFDCRIEDLFDPE

with 3 more sequence matches

26.1%

NZ_BBZG01000001.1and 1 other:

NZ_FOBF01000002.1 Lanthipeptides: BMX74_RS05765_lanthipeptide

Lanthipeptides: ASC57_RS06310_lanthipeptide

NLSVLKNNRAKAVRFTTLVALCDALDCQPGDLFTAE

+LS + F LVAL L C PG A+

DLSSASGGEGQTTSFPCLVALSLLLRCFPGQPQAAQ

19.6%

NZ_BBYJ01000018.1:

Lanthipeptides: AWQ71_RS24055_lanthipeptide

NRAKAVRFTTLVALCDALDCQPGD

+ F LVAL L C PG

GEGQTTSFPCLVALSLLLRCFPGQ

13.0%

NZ_CP067396.1:

Lanthipeptides: allorf_2936753_2936914_lanthipeptide

DALDCQPG

DAL C+PG

DALSCKPG

CORMATOL_RS10565

Leader:

MNASTAVLDSTILDELDKELEAQIIKELEPEMFG

Core:

LSRLLGNNGRWCTITKECMPSCN

Core with dehydrations:

LDhaRLLGNNGRWCysDhbIDhbKECysMPDhaCysN

antiSMASH-DB 4.0 matches for CORMATOL_RS10565

100.0%

NZ_CP050134.2and 3 others:

NZ_EQ973330.1 Lanthipeptides: CORMATOL_RS10565_lanthipeptideNZ_LR134504.1 Lanthipeptides: EL293_RS07240_lanthipeptideNZ_LR134504.1 Lanthipeptides: EL293_RS07240_lanthipeptide

Lanthipeptides: HBA49_RS00770_lanthipeptide

LSRLLGNNGRWCTITKECMPSCN

70.8%

NZ_LT630004.1:

Lanthipeptides: BQ5796_RS17475_lanthipeptide

LSRLLGNNGRWCTITKECMPSCN

LS LLGN+G++CT+T ECMPSCN

LSSLLGNDGKFCTLTVECMPSCN

56.7%

NZ_CP084530.1and 1 other:

NZ_CP084530.1 Lanthipeptides: LDO05_RS02075_lanthipeptide

Lanthipeptides: LDO05_RS02075_lanthipeptide

LSRLLGNNGRWCTITKECMPSCN

LS LGNNG WCT+TKEC SCN

LSNYLGNNGGWCTLTKECQRSCN

with 103 more sequence matches

Only the first 10 are displayed here.

56.2%

NC_006322.1and 7 others:

NC_006322.1 Lanthipeptides: BLI_RS20295_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07805_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07805_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08835_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08835_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11865_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11865_lanthipeptide

Lanthipeptides: BLI_RS20295_lanthipeptide

LSRLLGNNGRWCTITKECMPSCN

LS+ LGNNG CT+TKECMPSCN

LSKPLGNNGYLCTVTKECMPSCN

56.2%

NZ_CP015591.1and 19 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27560_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29375_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29370_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29365_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29955_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29950_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29945_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29955_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29950_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29945_lanthipeptideNZ_JACYOF010000027.1 Lanthipeptides: IGI01_RS29005_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29780_lanthipeptideNZ_NVJC01000007.1 Lanthipeptides: COM38_RS07400_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23035_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23030_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23025_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23035_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23030_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23025_lanthipeptide

Lanthipeptides: A7A70_RS27565_lanthipeptide

LSRLLGNNGRWCTITKECMPSCN

LS LGNNG +CT+TKECMPSCN

LSSWLGNNGGYCTLTKECMPSCN

55.6%

NZ_CP025249.1and 1 other:

NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide

Lanthipeptides: CWT12_RS00385_lanthipeptide

LSRLLGNNGRWCTITKECMPSCN

LSR LGN G CT+TKEC CN

LSRKLGNTGYVCTLTKECQRMCN

53.8%

NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS01720_lanthipeptide

Lanthipeptides: EL241_RS01720_lanthipeptide

LSRLLGNNGRWCTITKECMPSCN

+S+ LGN GR CT+TKEC CN

VSKNLGNKGRICTLTKECQSMCN

53.6%

NZ_KE384107.1:

Lanthipeptides: G586_RS23925_lanthipeptide

LSRLLGNNGRWCTITKECMPSCN

LS LGN G +CTITKEC CN

LSASLGNRGSYCTITKECQACCN

53.3%

NZ_AKXV01000031.1and 4 others:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptideNZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide

Lanthipeptides: Y19_RS0109895_lanthipeptide

LSRLLGNNGRWCTITKECMPSCN

LS LGN G WCT+TKEC P+CN

LSDFLGNQGGWCTLTKECQPNCN

53.3%

NZ_BNBV01000031.1and 1 other:

NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22995_lanthipeptide

Lanthipeptides: IE286_RS22995_lanthipeptide

LSRLLGNNGRWCTITKECMPSCN

LS LGN+G WCT+TKEC P+CN

LSDALGNSGGWCTLTKECQPNCN

53.3%

NZ_CP107567.1and 3 others:

NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide

Lanthipeptides: OGH68_RS19760_lanthipeptide

LSRLLGNNGRWCTITKECMPSCN

LS LGN G WCT+TKEC P+CN

LSDWLGNQGGWCTLTKECQPNCN

53.3%

NZ_LT985747.1and 1 other:

NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide

Lanthipeptides: C8268_RS00165_lanthipeptide

LSRLLGNNGRWCTITKECMPSCN

LS LGN G WCT+TKEC SCN

LSDYLGNKGGWCTLTKECQRSCN

53.1%

NC_018499.1and 10 others:

NC_018499.1 Lanthipeptides: BCK_RS27855_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27850_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27860_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27855_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27850_lanthipeptideNZ_JAOPQW010000026.1 Lanthipeptides: OCD10_RS25275_lanthipeptideNZ_JAOPQW010000026.1 Lanthipeptides: OCD10_RS25270_lanthipeptideNZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27570_lanthipeptideNZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27565_lanthipeptideNZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27560_lanthipeptide

Lanthipeptides: BCK_RS27860_lanthipeptide

LSRLLGNNGRWCTITKECMPSCN

LS LGN G +CT+TKECMPSCN

LSSWLGNKGGYCTLTKECMPSCN

MIBiG 4.0 matches for CORMATOL_RS10565

56.7%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

LSRLLGNNGRWCTITKECMPSCN

LS LGNNG WCT+TKEC P+CN

LSNALGNNGGWCTLTKECQPNCN

53.6%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

LSRLLGNNGRWCTITKECMPSCN

+S LGN G +CT+T ECMPSCN

ISCRLGNKGAYCTLTVECMPSCN

20.5%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

CTITKECMPSCN

CT++KEC P+CN

CTLSKECQPNCN

CORMATOL_RS14310

Leader:

MNQQPSNHDRVQNYSQDELRAMIENEEAVDGG

Core:

THPSTLIPISIALCPTTRCSRRC

Core with dehydrations:

DhbHPDhaDhbLIPIDhaIALCysPDhbDhbRCysDhaRRCys

antiSMASH-DB 4.0 matches for CORMATOL_RS14310

100.0%

NZ_CP050134.2and 3 others:

NZ_EQ973330.1 Lanthipeptides: CORMATOL_RS14310_lanthipeptideNZ_LR134504.1 Lanthipeptides: EL293_RS13085_lanthipeptideNZ_LR134504.1 Lanthipeptides: EL293_RS13085_lanthipeptide

Lanthipeptides: HBA49_RS00775_lanthipeptide

THPSTLIPISIALCPTTRCSRRC

41.9%

NZ_AP026714.1and 21 others:

NZ_AP026714.1 Lanthipeptides: PO853_RS06520_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptide

Lanthipeptides: PO853_RS06520_lanthipeptide

PSTLIPISIAL--------CPTTRCSRRC

P+ IPISIA+ CPT+ C+R C

PTITIPISIAVSGWISDKTCPTSVCTRAC

41.7%

NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS13590_lanthipeptide

Lanthipeptides: EL241_RS13590_lanthipeptide

IPISIALCPTTRCSRRC

+P+SIALCPT +C+ +C

VPLSIALCPTAKCTSKC

with 80 more sequence matches

Only the first 10 are displayed here.

39.1%

NZ_CP063142.1and 1 other:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21460_lanthipeptide

Lanthipeptides: HPB58_RS21460_lanthipeptide

IPISIALCPTT

IPIS+A CPTT

IPISLAACPTT

38.5%

NZ_JFCR01000001.1and 3 others:

NZ_JFCR01000001.1 Lanthipeptides: JQ44_RS10210_lanthipeptideNZ_JUNC01000006.1 Lanthipeptides: ADC63_RS10380_lanthipeptideNZ_JUNC01000006.1 Lanthipeptides: ADC63_RS10380_lanthipeptide

Lanthipeptides: JQ44_RS10210_lanthipeptide

SIALCPTTRCSRRC

S+ALCPTT+CS C

SVALCPTTKCSSAC

38.2%

NZ_WIXN01000006.1and 1 other:

NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide

Lanthipeptides: GHD25_RS06900_lanthipeptide

THPSTLIPISIALCPTTRC

THP+T+IP+S+A+CPTT C

THPTTIIPVSLAVCPTTTC

37.9%

NZ_CP042598.1and 3 others:

NZ_CP042598.1 Lanthipeptides: FUT28_RS13815_lanthipeptideNZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11625_lanthipeptideNZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11625_lanthipeptide

Lanthipeptides: FUT28_RS13815_lanthipeptide

STLIPISIALCPTTRCSRRC

ST++ SI+LCPTT+C+ +C

STIVDASISLCPTTKCTSQC

37.9%

NZ_JADPDT010000005.1and 1 other:

NZ_JADPDT010000005.1 Lanthipeptides: I4V19_RS09875_lanthipeptide

Lanthipeptides: I4V19_RS09875_lanthipeptide

STLIPISIALCPTTRCSRRC

ST++ SI+LCPTT+C+ +C

STVVEASISLCPTTKCTSKC

36.7%

NZ_BQME02000001.1and 5 others:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide

Lanthipeptides: MFF31_RS04085_lanthipeptide

LIPISIALCPTTRCS

+IPIS+A CPTTRC+

IIPISLAACPTTRCA

36.7%

NZ_MJEJ02000054.1and 3 others:

NZ_MJEJ02000054.1 Lanthipeptides: BH683_RS28810_lanthipeptideNZ_QJSP01000005.1 Lanthipeptides: DFR67_RS30760_lanthipeptideNZ_QJSP01000005.1 Lanthipeptides: DFR67_RS30760_lanthipeptide

Lanthipeptides: BH683_RS28810_lanthipeptide

THPSTLI---PISIALCPTTRCS

THP+T+ +S+ALCPT +C+

THPTTISLASALSVALCPTFKCT

35.7%

NZ_CP017762.1and 3 others:

NZ_CP017762.1 Lanthipeptides: BKP57_RS21840_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptide

Lanthipeptides: BKP57_RS21840_lanthipeptide

IPISIALCPTTRCSRRC

+ SIALCPT CS +C

VAASIALCPTLACSSKC

35.3%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide

Lanthipeptides: WH45_RS23705_lanthipeptide

PSTLIPISIALCPTTRCS

P+T+IP+S+A+CPTTRC+

PATIIPVSLAICPTTRCA

34.6%

NZ_CP016767.1and 13 others:

NZ_CP016767.1 Lanthipeptides: BCV50_RS13415_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptideNZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07925_lanthipeptideNZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07925_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptideNZ_NUIO01000031.1 Lanthipeptides: CN977_RS23165_lanthipeptideNZ_NUIO01000031.1 Lanthipeptides: CN977_RS23165_lanthipeptide

Lanthipeptides: BCV50_RS13415_lanthipeptide

ISIALCPTTRCSRRC

IS CPTT C+R C

ISSNTCPTTACTRAC

MIBiG 4.0 matches for CORMATOL_RS14310

24.3%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

HPSTLIPISIALCPTTRCSRRC

+ +S A CPTT+C+ RC

QAGVAVGVSAAFCPTTKCTSRC

23.1%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

LCPTTRCSRRC

CPTT+C+ +C

FCPTTKCTSKC

CORMATOL_RS14315

Leader:

MKKYTKQEWAYTTIGLALGVAVALSLGQGNYMMGA

Core:

LSAFFGICGYLLARKSARKQ

Core with dehydrations:

LDhaAFFGICysGYLLARKDhaARKQ

antiSMASH-DB 4.0 matches for CORMATOL_RS14315

100.0%

NZ_CP050134.2and 3 others:

NZ_EQ973330.1 Lanthipeptides: CORMATOL_RS14315_lanthipeptideNZ_LR134504.1 Lanthipeptides: EL293_RS13090_lanthipeptideNZ_LR134504.1 Lanthipeptides: EL293_RS13090_lanthipeptide

Lanthipeptides: HBA49_RS00780_lanthipeptide

LSAFFGICGYLLARKSARKQ

28.0%

NZ_VIGJ01000001.1:

Lanthipeptides: FLM44_RS26105_lanthipeptide

SAFFGICGYLLARKSA

S G+C LLA + A

STLSGVCRTLLAAQEA

20.0%

NZ_CP015405.2and 1 other:

NZ_CP053228.1 Lanthipeptides: HL650_RS06245_lanthipeptide

Lanthipeptides: A4V09_RS08280_lanthipeptide

SAFFGICGY

+AFFG C +

TAFFGTCSF

allorf_437242_437442

Leader:

MGVSGSWLYGA

Core:

AFLKLQLSTCEAWLWRGVGWPCAGAASLVGWGLLVQLCRGACFSISPSPPNLKPR

Core with dehydrations:

AFLKLQLDhaDhbCysEAWLWRGVGWPCysAGAADhaLVGWGLLVQLCysRGACysFDhaIDhaPDhaPPNLKPR

antiSMASH-DB 4.0 matches for allorf_437242_437442

100.0%

NZ_EQ973330.1:

Lanthipeptides: allorf_437242_437442_lanthipeptide

AFLKLQLSTCEAWLWRGVGWPCAGAASLVGWGLLVQLCRGACFSISPSPPNLKPR

50.9%

NZ_LR134504.1:

Lanthipeptides: allorf_1621406_1621576_lanthipeptide

AFLKLQLSTCEAWLWRGVGWPCAGAASLVG

A LKLQ STCEAWLWRGVGWPCAGAASLVG

AGLKLQFSTCEAWLWRGVGWPCAGAASLVG

21.8%

NZ_CP050134.2:

Lanthipeptides: allorf_0180903_0181139_lanthipeptide

AFLKLQLSTCEA

with 3 more sequence matches

16.4%

NZ_JQBU01000033.1and 1 other:

NZ_JQBV01000009.1 Lanthipeptides: IV76_RS12120_lanthipeptide

Lanthipeptides: IV75_RS14620_lanthipeptide

CAGAASLVGWGLLVQLCRGAC

CAG A+L+ LV+ +G C

CAGFATLMSSIGLVKTIKGKC

14.5%

NZ_JACHJQ010000008.1:

Lanthipeptides: allorf_202185_202280_lanthipeptide

QLSTCEAWLWRGVGWPCA

++STC A G +PCA

RVSTCAASRNVGSDYPCA

12.7%

NZ_FNYB01000021.1and 1 other:

NZ_KB976303.1 Lanthipeptides: allorf_014456_014554_lanthipeptide

Lanthipeptides: allorf_13761_13859_lanthipeptide

AFLKLQLSTCEAWLWRGVG

A +L+ +C+ L+RG G

ANEELRYKSCDGSLYRGKG

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 27.48 out of 30.22

Confidence: strong

Additional weak hits (3):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.48 out of 29.38

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.86 out of 29.65

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.97 out of 24.78

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

CORMATOL_RS10555 - Class II

Cleavage pHMM score: -2.00

RODEO score: 0

Monoisotopic mass: 4769.5 Da

Molecular weight: 4772.4 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 4790.5 Da N = 1; 4808.5 Da N = 2; 4826.5 Da N = 3

CORMATOL_RS10565 - Class II

Cleavage pHMM score: -4.00

RODEO score: 0

Monoisotopic mass: 2523.2 Da

Molecular weight: 2524.9 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2543.0 Da N = 1

CORMATOL_RS14310 - Class II

Cleavage pHMM score: -3.50

RODEO score: 0

Monoisotopic mass: 2399.3 Da

Molecular weight: 2400.9 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2418.9 Da N = 1; 2436.9 Da N = 2; 2454.9 Da N = 3; 2472.9 Da N = 4

CORMATOL_RS14315 - Class II

Cleavage pHMM score: -6.30

RODEO score: 0

Monoisotopic mass: 2192.2 Da

Molecular weight: 2193.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2211.6 Da N = 1

allorf_437242_437442 - Class II

Cleavage pHMM score: -7.10

RODEO score: 0

Monoisotopic mass: 5802.1 Da

Molecular weight: 5805.8 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 5823.9 Da N = 1; 5841.9 Da N = 2

TFBS definitions

Regulator	Description
ClgR	Caseinolytic protease gene regulator

NZ_EQ973329.1 - Region 1 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 846,353 - 867,442 nt. (total: 21,090 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: synthetase

CORMATOL_RS07990: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002309.2	0.37	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000677.5	0.34	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0001456.3	0.31	terpene	isorenieratene	Streptomyces argillaceus
BGC0001911.3	0.31	terpene	raimonol	Streptomyces anulatus
BGC0001910.4	0.30	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0000664.5	0.29	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000665.5	0.29	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000678.5	0.29	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000633.3	0.28	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.28	terpene	isorenieratene	Streptomyces collinus Tu 365

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002309.2	0.37	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000677.5	0.34	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0001456.3	0.31	terpene	isorenieratene	Streptomyces argillaceus
BGC0001911.3	0.31	terpene	raimonol	Streptomyces anulatus
BGC0001910.4	0.30	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0000664.5	0.29	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000665.5	0.29	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000678.5	0.29	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000633.3	0.28	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.28	terpene	isorenieratene	Streptomyces collinus Tu 365

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

CORMATOL_RS07990: PT_FPPS_like

Domain 1 (48 - 332): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.96 out of 30.25

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.01 out of 24.78

Confidence: medium

Additional weak hits (6):

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.05 out of 21.55

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.51 out of 23.43

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.68 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.39 out of 29.38

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.28 out of 27.78

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.42 out of 33.14

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
ColR	Phenol-responsive regulator
LexA variant 2	Repressor of DNA damage response

NZ_EQ973328.1 - Region 1 - NI-siderophore

Download region GenBank file

Download region SVG

Location: 96,755 - 127,511 nt. (total: 30,757 nt) Show pHMM detection rules used

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidase

CORMATOL_RS00420: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

CORMATOL_RS00425: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

CORMATOL_RS00510: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: acetyltransferase aminotransferase

CORMATOL_RS00490: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

CORMATOL_RS00505: aminotransferase class V

smcogs: SMCOG1139: aminotransferase class V

Hydrolases: esterase

CORMATOL_RS00550: putative esterase

smcogs: SMCOG1104: putative esterase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002692.2	0.49	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0001408.5	0.45	other (other)	xanthoferrin	Xanthomonas oryzae pv. oryzae KACC 10331
BGC0002527.2	0.45	other (other)	vibrioferrin	Azotobacter vinelandii CA
BGC0002733.3	0.44	other (other)	sinapigladioside	Burkholderia gladioli
BGC0000734.3	0.42	saccharide	capsular polysaccharide	Pasteurella multocida
BGC0000041.3	0.42	PKS	oronofacic acid	Pseudomonas syringae
BGC0000794.5	0.40	saccharide	S-layer glycan	Geobacillus stearothermophilus
BGC0001410.3	0.40	saccharide	polysaccharide A	Bacteroides fragilis
BGC0000783.3	0.40	saccharide	O-antigen	Xanthomonas oryzae pv. oryzae
BGC0000772.5	0.40	saccharide	lipopolysaccharide	Brucella melitensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002692.2	0.49	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0001408.5	0.45	other (other)	xanthoferrin	Xanthomonas oryzae pv. oryzae KACC 10331
BGC0002527.2	0.45	other (other)	vibrioferrin	Azotobacter vinelandii CA
BGC0002733.3	0.44	other (other)	sinapigladioside	Burkholderia gladioli
BGC0000734.3	0.42	saccharide	capsular polysaccharide	Pasteurella multocida
BGC0000041.3	0.42	PKS	oronofacic acid	Pseudomonas syringae
BGC0000794.5	0.40	saccharide	S-layer glycan	Geobacillus stearothermophilus
BGC0001410.3	0.40	saccharide	polysaccharide A	Bacteroides fragilis
BGC0000783.3	0.40	saccharide	O-antigen	Xanthomonas oryzae pv. oryzae
BGC0000772.5	0.40	saccharide	lipopolysaccharide	Brucella melitensis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 16.04 out of 18.57

Confidence: medium

Additional weak hits (6):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 20.53 out of 30.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.73 out of 30.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.88 out of 26.06

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.84 out of 27.78

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 22.07 out of 30.97

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.88 out of 28.19

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
ToxT	Regulator of MSHA biosynthesis

NZ_EQ973328.1 - Region 2 - NRP-metallophore,NRPS

Download region GenBank file

Download region SVG

Location: 350,467 - 399,965 nt. (total: 49,499 nt) Show pHMM detection rules used

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

CORMATOL_RS01685: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Hydrolases: esterase hydrolase

CORMATOL_RS01660: enterobactin/ferric enterobactin esterase

smcogs: SMCOG1098: enterobactin/ferric enterobactin esterase

CORMATOL_RS01680: isochorismatase

smcogs: SMCOG1027: isochorismatase

Isomerases: isomerase

CORMATOL_RS01675: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase

CORMATOL_RS01655: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

CORMATOL_RS01670: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001833.4	0.69	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	0.65	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.65	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.64	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.64	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.62	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.58	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000342.4	0.58	NRPS	enniatin	Fusarium equiseti
BGC0001251.4	0.58	NRPS	epichloenin A	Epichloe festucae
BGC0001250.4	0.58	NRPS	epichloenin A	Epichloe festucae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001833.4	0.67	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	0.66	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.66	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.65	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.65	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.64	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.63	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000342.4	0.63	NRPS	enniatin	Fusarium equiseti
BGC0001251.4	0.62	NRPS	epichloenin A	Epichloe festucae
BGC0001250.4	0.62	NRPS	epichloenin A	Epichloe festucae

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.75 out of 18.57

Confidence: strong

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.79 out of 23.79

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.03 out of 27.78

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.22 out of 18.57

Confidence: strong

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.82 out of 21.84

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.21 out of 27.78

Confidence: medium

Additional weak hits (11):

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.46 out of 20.47

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.23 out of 26.06

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.63 out of 39.62

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.73 out of 27.78

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 20.99 out of 33.14

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 24.69 out of 36.53

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.32 out of 26.06

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 27.05 out of 39.62

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 20.54 out of 31.73

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.30 out of 20.01

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.52 out of 29.65

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 2, location 350466 - 399965:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ser)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CORMATOL_RS01655: Ser

Search NORINE for peptide: strict or relaxed

AMP-binding (468..849): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWELHFITSGEHNLYGPTEAAIDVTA
Nearest Stachelhaus code(s):: Ser DVWHISLIDK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

CORMATOL_RS01670: diOH-Bz

Search NORINE for peptide: strict or relaxed

AMP-binding (26..432): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: SESLFTMSSPGGALQVGGAQQVFGMAEGLVNYTR
Nearest Stachelhaus code(s):: diOH-Bz TMPSQGVVNK (94% 8Å match)
Stachelhaus code match:: 90% (moderate)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
IolR	Regulator of the inositol catabolism
MexT	Global virulence regulator
ToxT	Regulator of MSHA biosynthesis

NZ_EQ973328.1 - Region 3 - terpene

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Location: 576,248 - 597,117 nt. (total: 20,870 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

CORMATOL_RS02610: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

CORMATOL_RS02650: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: transferase

CORMATOL_RS02580: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

Hydrolases: hydrolase

CORMATOL_RS02605: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

Translocases: transporter

CORMATOL_RS02640: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000650.3	0.50	terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0000637.3	0.48	terpene	carotenoid	Corynebacterium glutamicum
BGC0000645.3	0.45	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0001553.5	0.43	NRPS, PKS	clifednamide A	Streptomyces sp. JV178
BGC0000636.3	0.43	terpene	carotenoid	Brevibacterium linens
BGC0002150.2	0.42	ribosomal	triculamin	Streptomyces triculaminicus
BGC0002151.2	0.42	ribosomal	alboverticillin	Streptomyces griseocarneus
BGC0000664.5	0.42	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000630.3	0.41	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000649.3	0.40	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000650.3	0.50	terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0000637.3	0.48	terpene	carotenoid	Corynebacterium glutamicum
BGC0000645.3	0.45	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0001553.5	0.43	NRPS, PKS	clifednamide A	Streptomyces sp. JV178
BGC0000636.3	0.43	terpene	carotenoid	Brevibacterium linens
BGC0002150.2	0.42	ribosomal	triculamin	Streptomyces triculaminicus
BGC0002151.2	0.42	ribosomal	alboverticillin	Streptomyces griseocarneus
BGC0000664.5	0.42	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000630.3	0.41	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000649.3	0.40	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene		PSPP	C30	acyclic	PP
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none
triterpene		squalene	C30	acyclic	none
tetraterpene	C40 carotenoid	phytoene	C40	acyclic	none
triterpene		hydroxysqualene	C30	acyclic	OH

Genes with terpene domains:

CORMATOL_RS02615: PT_phytoene_like

Domain 1 (2 - 265): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → PSPP; FPP → diapophytoene; FPP → squalene; GGPP → phytoene; PSPP → hydroxysqualene

Transcription Factor Binding Sites

Binding sites found:

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.82 out of 21.84

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.87 out of 30.25

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.06 out of 19.26

Confidence: strong

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.98 out of 27.55

Confidence: medium

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 24.83 out of 29.65

Confidence: medium

Additional weak hits (9):

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.31 out of 25.75

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.62 out of 32.93

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.72 out of 32.93

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 20.55 out of 30.25

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 24.12 out of 32.38

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.89 out of 29.65

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 18.85 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.37 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 19.22 out of 28.14

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
PP	Diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
ColR	Phenol-responsive regulator
GnfM	Regulator of nitrogen-fixation genes
LexA variant 1	Repressor of DNA damage response
MexT	Global virulence regulator

NZ_EQ973328.1 - Region 4 - NRPS,NRPS-like

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Location: 723,099 - 770,261 nt. (total: 47,163 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: halogenase

CORMATOL_RS03240: halogenase

smcogs: SMCOG1119: halogenase

Hydrolases: phosphatase

CORMATOL_RS03160: inositol monophosphatase

smcogs: SMCOG1207: inositol monophosphatase

CORMATOL_RS03165: inositol monophosphatase

smcogs: SMCOG1207: inositol monophosphatase

Ligases: ligase

CORMATOL_RS03245: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

CORMATOL_RS03290: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

CORMATOL_RS13555: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

CORMATOL_RS14650: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

CORMATOL_RS14655: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001251.4	0.70	NRPS	epichloenin A	Epichloe festucae
BGC0001250.4	0.70	NRPS	epichloenin A	Epichloe festucae
BGC0001833.4	0.66	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0000307.4	0.57	NRPS	AbT1	Aureobasidium pullulans
BGC0001160.5	0.45	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.45	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001876.2	0.43	NRPS	thalassospiramide A	Thalassospira sp. CNJ-328
BGC0000351.5	0.42	NRPS	exochelin	Mycolicibacterium smegmatis MC2 155
BGC0002765.2	0.38	NRPS	Keanumycin A, Keanumycin B, Keanumycin C	Pseudomonas sp. QS1027
BGC0002158.2	0.37	NRPS, PKS	tenuazonic acid	Pyricularia oryzae 70-15

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001251.4	0.68	NRPS	epichloenin A	Epichloe festucae
BGC0001250.4	0.68	NRPS	epichloenin A	Epichloe festucae
BGC0001833.4	0.66	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0000307.4	0.62	NRPS	AbT1	Aureobasidium pullulans
BGC0001160.5	0.55	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.55	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001876.2	0.54	NRPS	thalassospiramide A	Thalassospira sp. CNJ-328
BGC0000351.5	0.54	NRPS	exochelin	Mycolicibacterium smegmatis MC2 155
BGC0002765.2	0.51	NRPS	Keanumycin A, Keanumycin B, Keanumycin C	Pseudomonas sp. QS1027
BGC0001843.2	0.51	NRPS	tridecaptin M	Paenibacillus sp. M-152

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.22 out of 18.46

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.24 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.29 out of 27.78

Confidence: medium

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 22.14 out of 27.18

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.56 out of 20.47

Confidence: medium

Additional weak hits (8):

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.13 out of 25.75

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.93 out of 27.55

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.91 out of 28.14

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.06 out of 26.33

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 27.38 out of 39.62

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.12 out of 30.98

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.79 out of 26.85

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.56 out of 33.14

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 4, location 723098 - 770261:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (Ala)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 5, location 723098 - 766986:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (Ala)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 6, location 727957 - 770261:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (Ala)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CORMATOL_RS03245: Ala

Search NORINE for peptide: strict or relaxed

AMP-binding (492..872): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: NDLSFDMSIFEGNSVLGGDDVLGGATEASIHSTF
Nearest Stachelhaus code(s):: Ala DMFNVGLIHK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

CORMATOL_RS14655: X

AMP-binding (214..586): X

nrpys: Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: HAATFDISLDELHGIVGGERNVYGPTEATIWATE
Nearest Stachelhaus code(s):: Gly DILQLGVIWK (68% 8Å match)
Stachelhaus code match:: 70% (weak)

CORMATOL_RS13555: NH2

CAL_domain (145..454): NH2

minowa: NH2

Prediction, score:

NH2: 48.5
Acetyl-CoA: 33.7
shikimic_acid: 0.0
fatty_acid: 0.0
AHBA: 0.0

CORMATOL_RS03290: X

AMP-binding (28..400): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: IKDHWTFAQLKPESLNTYD--------AAIWLHS
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
NrdR	Represses ribonucleotide reductase encoding genes
RpoN	Regulator of nitrogen assimilation and virulence
VqsM	Regulator of quorum-sensing signalling systems