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Overview
6.1
7.1
8.1
8.2
8.3
8.4

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_EQ973330.1 (Corynebacterium matruchotii ATCC 33806)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 6.1 | lanthipeptide-class-ii | 432,414 | 455,014 |

NZ_EQ973329.1 (Corynebacterium matruchotii ATCC 33806)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 7.1 | terpene-precursor | 846,353 | 867,442 |

NZ_EQ973328.1 (Corynebacterium matruchotii ATCC 33806)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 8.1 | NI-siderophore | 96,755 | 127,511 |
Region 8.2 | NRP-metallophore,NRPS | 350,467 | 399,965 | Low | aminochelin/azotochelin/protochelin | NRPS:Type I
Region 8.3 | terpene | 576,248 | 597,117 | Low | carotenoid | terpene
Region 8.4 | NRPS,NRPS-like | 723,099 | 770,261 |  |

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 6.1 | lanthipeptide-class-ii | 432,414 | 455,014 |
Region 7.1 | terpene-precursor | 846,353 | 867,442 |
Region 8.1 | NI-siderophore | 96,755 | 127,511 |
Region 8.2 | NRP-metallophore,NRPS | 350,467 | 399,965 | Low | aminochelin/azotochelin/protochelin | NRPS:Type I
Region 8.3 | terpene | 576,248 | 597,117 | Low | carotenoid | terpene
Region 8.4 | NRPS,NRPS-like | 723,099 | 770,261 |  |

No secondary metabolite regions were found in these records:
  NZ_EQ973335.1 (Corynebacterium matruchotii ATCC 33806)
  NZ_EQ973334.1 (Corynebacterium matruchotii ATCC 33806)
  NZ_EQ973333.1 (Corynebacterium matruchotii ATCC 33806)
  NZ_EQ973332.1 (Corynebacterium matruchotii ATCC 33806)
  NZ_EQ973331.1 (Corynebacterium matruchotii ATCC 33806)

Compact view
NZ_EQ973330.1 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 432,414 - 455,014 nt. (total: 22,601 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
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Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase
CORMATOL_RS10570: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

CORMATOL_RS10590: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000525.5 |  | 0.60 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0002005.2 |  | 0.51 | ribosomal | RaxX | Xanthomonas oryzae pv. oryzae
BGC0000517.4 |  | 0.51 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0001210.5 |  | 0.49 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000626.3 |  | 0.48 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000539.5 |  | 0.48 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0002110.3 |  | 0.47 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0001391.3 |  | 0.47 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0000521.3 |  | 0.46 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0001311.5 |  | 0.46 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000525.5 |  | 0.60 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0002005.2 |  | 0.51 | ribosomal | RaxX | Xanthomonas oryzae pv. oryzae
BGC0000517.4 |  | 0.51 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0001210.5 |  | 0.49 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000626.3 |  | 0.48 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000539.5 |  | 0.48 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0002110.3 |  | 0.47 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0001391.3 |  | 0.47 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0000521.3 |  | 0.46 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0001311.5 |  | 0.46 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for CORMATOL_RS10570

CORMATOL_RS10555
Leader:
MVCHLDQLLAEREMTLAA
Core:
L A D Q V G V T V A N L S V L K N N R A K A V R F T T L V A L C D A L D C Q P G D L F T A E
Core with dehydrations:
L A D Q V G V Dhb V A N L Dha V L K N N R A K A V R F Dhb Dhb L V A L Cys D A L D Cys Q P G D L F Dhb A E

#### antiSMASH-DB 4.0 matches for CORMATOL_RS10555

100.0%
NZ_EQ973330.1 and 2 others:
NZ_LR134504.1 Lanthipeptides: EL293_RS07235_lanthipeptide NZ_LR134504.1 Lanthipeptides: EL293_RS07235_lanthipeptide
Lanthipeptides: CORMATOL_RS10555_lanthipeptide
1
L A D Q V G V T V A N L S V L K N N R A K A V R F T T L V A L C D A L D C Q P G D L F T A E
46
L A D Q V G V T V A N L S V L K N N R A K A V R F T T L V A L C D A L D C Q P G D L F T A E
1
L A D Q V G V T V A N L S V L K N N R A K A V R F T T L V A L C D A L D C Q P G D L F T A E
46
28.3%
NZ_BBZK01000004.1:
Lanthipeptides: BGP73_RS05180_lanthipeptide
27
T L V A L C D A L D C Q P G D L F T
44
T L A+C L D C Q P G D L T
1
T L S A I C R E L D C Q P G D L L T
18
26.5%
NZ_SBIS02000007.1:
Lanthipeptides: EPL00_RS13710_lanthipeptide
5
V G V T V A N L S V L K N N R A K A V R F T T L V A L C D A L D C Q P G D L F T A E
46
V G V T ++ ++ R L D D C+ D L F E
1
V G V T R Q T I N A I E R E R Y D P-S I E L A F K L A D H F D C R I E D L F D P E
41
with 3 more sequence matches
26.1%
NZ_BBZG01000001.1 and 1 other:
NZ_FOBF01000002.1 Lanthipeptides: BMX74_RS05765_lanthipeptide
Lanthipeptides: ASC57_RS06310_lanthipeptide
11
N L S V L K N N R A K A V R F T T L V A L C D A L D C Q P G D L F T A E
46
+L S + F L V A L L C P G A+
9
D L S S A S G G E G Q T T S F P C L V A L S L L L R C F P G Q P Q A A Q
44
19.6%
NZ_BBYJ01000018.1:
Lanthipeptides: AWQ71_RS24055_lanthipeptide
18
N R A K A V R F T T L V A L C D A L D C Q P G D
41
+ F L V A L L C P G
1
G E G Q T T S F P C L V A L S L L L R C F P G Q
24
13.0%
NZ_CP067396.1:
Lanthipeptides: allorf_2936753_2936914_lanthipeptide
33
D A L D C Q P G
40
D A L C+P G
1
D A L S C K P G
8
CORMATOL_RS10565
Leader:
MNASTAVLDSTILDELDKELEAQIIKELEPEMFG
Core:
L S R L L G N N G R W C T I T K E C M P S C N
Core with dehydrations:
L Dha R L L G N N G R W Cys Dhb I Dhb K E Cys M P Dha Cys N

#### antiSMASH-DB 4.0 matches for CORMATOL_RS10565

100.0%
NZ_CP050134.2 and 3 others:
NZ_EQ973330.1 Lanthipeptides: CORMATOL_RS10565_lanthipeptide NZ_LR134504.1 Lanthipeptides: EL293_RS07240_lanthipeptide NZ_LR134504.1 Lanthipeptides: EL293_RS07240_lanthipeptide
Lanthipeptides: HBA49_RS00770_lanthipeptide
1
L S R L L G N N G R W C T I T K E C M P S C N
23
L S R L L G N N G R W C T I T K E C M P S C N
1
L S R L L G N N G R W C T I T K E C M P S C N
23
70.8%
NZ_LT630004.1:
Lanthipeptides: BQ5796_RS17475_lanthipeptide
1
L S R L L G N N G R W C T I T K E C M P S C N
23
L S L L G N+G++C T+T E C M P S C N
2
L S S L L G N D G K F C T L T V E C M P S C N
24
56.7%
NZ_CP084530.1 and 1 other:
NZ_CP084530.1 Lanthipeptides: LDO05_RS02075_lanthipeptide
Lanthipeptides: LDO05_RS02075_lanthipeptide
1
L S R L L G N N G R W C T I T K E C M P S C N
23
L S L G N N G W C T+T K E C S C N
8
L S N Y L G N N G G W C T L T K E C Q R S C N
30
with 103 more sequence matches
Only the first 10 are displayed here.
56.2%
NC_006322.1 and 7 others:
NC_006322.1 Lanthipeptides: BLI_RS20295_lanthipeptide NZ_CP033218.1 Lanthipeptides: D9Y32_RS07805_lanthipeptide NZ_CP033218.1 Lanthipeptides: D9Y32_RS07805_lanthipeptide NZ_LQYL01000021.1 Lanthipeptides: B4090_RS08835_lanthipeptide NZ_LQYL01000021.1 Lanthipeptides: B4090_RS08835_lanthipeptide NZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11865_lanthipeptide NZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11865_lanthipeptide
Lanthipeptides: BLI_RS20295_lanthipeptide
1
L S R L L G N N G R W C T I T K E C M P S C N
23
L S+ L G N N G C T+T K E C M P S C N
10
L S K P L G N N G Y L C T V T K E C M P S C N
32
56.2%
NZ_CP015591.1 and 19 others:
NZ_CP015591.1 Lanthipeptides: A7A70_RS27560_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29375_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29370_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29365_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29955_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29950_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29945_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29955_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29950_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29945_lanthipeptide NZ_JACYOF010000027.1 Lanthipeptides: IGI01_RS29005_lanthipeptide NZ_NUBO01000052.1 Lanthipeptides: CN575_RS29780_lanthipeptide NZ_NVJC01000007.1 Lanthipeptides: COM38_RS07400_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23035_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23030_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23025_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23035_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23030_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23025_lanthipeptide
Lanthipeptides: A7A70_RS27565_lanthipeptide
1
L S R L L G N N G R W C T I T K E C M P S C N
23
L S L G N N G +C T+T K E C M P S C N
10
L S S W L G N N G G Y C T L T K E C M P S C N
32
55.6%
NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide
Lanthipeptides: CWT12_RS00385_lanthipeptide
1
L S R L L G N N G R W C T I T K E C M P S C N
23
L S R L G N G C T+T K E C C N
5
L S R K L G N T G Y V C T L T K E C Q R M C N
27
53.8%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS01720_lanthipeptide
Lanthipeptides: EL241_RS01720_lanthipeptide
1
L S R L L G N N G R W C T I T K E C M P S C N
23
+S+ L G N G R C T+T K E C C N
4
V S K N L G N K G R I C T L T K E C Q S M C N
26
53.6%
NZ_KE384107.1:
Lanthipeptides: G586_RS23925_lanthipeptide
1
L S R L L G N N G R W C T I T K E C M P S C N
23
L S L G N G +C T I T K E C C N
6
L S A S L G N R G S Y C T I T K E C Q A C C N
28
53.3%
NZ_AKXV01000031.1 and 4 others:
NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptide NZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptide NZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide NZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide
Lanthipeptides: Y19_RS0109895_lanthipeptide
1
L S R L L G N N G R W C T I T K E C M P S C N
23
L S L G N G W C T+T K E C P+C N
8
L S D F L G N Q G G W C T L T K E C Q P N C N
30
53.3%
NZ_BNBV01000031.1 and 1 other:
NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22995_lanthipeptide
Lanthipeptides: IE286_RS22995_lanthipeptide
1
L S R L L G N N G R W C T I T K E C M P S C N
23
L S L G N+G W C T+T K E C P+C N
8
L S D A L G N S G G W C T L T K E C Q P N C N
30
53.3%
NZ_CP107567.1 and 3 others:
NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide
Lanthipeptides: OGH68_RS19760_lanthipeptide
1
L S R L L G N N G R W C T I T K E C M P S C N
23
L S L G N G W C T+T K E C P+C N
8
L S D W L G N Q G G W C T L T K E C Q P N C N
30
53.3%
NZ_LT985747.1 and 1 other:
NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide
Lanthipeptides: C8268_RS00165_lanthipeptide
1
L S R L L G N N G R W C T I T K E C M P S C N
23
L S L G N G W C T+T K E C S C N
8
L S D Y L G N K G G W C T L T K E C Q R S C N
30
53.1%
NC_018499.1 and 10 others:
NC_018499.1 Lanthipeptides: BCK_RS27855_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27850_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27860_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27855_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27850_lanthipeptide NZ_JAOPQW010000026.1 Lanthipeptides: OCD10_RS25275_lanthipeptide NZ_JAOPQW010000026.1 Lanthipeptides: OCD10_RS25270_lanthipeptide NZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27570_lanthipeptide NZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27565_lanthipeptide NZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27560_lanthipeptide
Lanthipeptides: BCK_RS27860_lanthipeptide
1
L S R L L G N N G R W C T I T K E C M P S C N
23
L S L G N G +C T+T K E C M P S C N
10
L S S W L G N K G G Y C T L T K E C M P S C N
32

#### MIBiG 4.0 matches for CORMATOL_RS10565

56.7%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
1
L S R L L G N N G R W C T I T K E C M P S C N
23
L S L G N N G W C T+T K E C P+C N
8
L S N A L G N N G G W C T L T K E C Q P N C N
30
53.6%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
1
L S R L L G N N G R W C T I T K E C M P S C N
23
+S L G N G +C T+T E C M P S C N
6
I S C R L G N K G A Y C T L T V E C M P S C N
28
20.5%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
12
C T I T K E C M P S C N
23
C T++K E C P+C N
28
C T L S K E C Q P N C N
39
CORMATOL_RS14310
Leader:
MNQQPSNHDRVQNYSQDELRAMIENEEAVDGG
Core:
T H P S T L I P I S I A L C P T T R C S R R C
Core with dehydrations:
Dhb H P Dha Dhb L I P I Dha I A L Cys P Dhb Dhb R Cys Dha R R Cys

#### antiSMASH-DB 4.0 matches for CORMATOL_RS14310

100.0%
NZ_CP050134.2 and 3 others:
NZ_EQ973330.1 Lanthipeptides: CORMATOL_RS14310_lanthipeptide NZ_LR134504.1 Lanthipeptides: EL293_RS13085_lanthipeptide NZ_LR134504.1 Lanthipeptides: EL293_RS13085_lanthipeptide
Lanthipeptides: HBA49_RS00775_lanthipeptide
1
T H P S T L I P I S I A L C P T T R C S R R C
23
T H P S T L I P I S I A L C P T T R C S R R C
1
T H P S T L I P I S I A L C P T T R C S R R C
23
41.9%
NZ_AP026714.1 and 21 others:
NZ_AP026714.1 Lanthipeptides: PO853_RS06520_lanthipeptide NZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptide NZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptide NZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptide NZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptide NZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptide NZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptide NZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptide NZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptide NZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptide NZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptide NZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptide NZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptide NZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptide NZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptide NZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptide NZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptide NZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptide NZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptide NZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptide NZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptide
Lanthipeptides: PO853_RS06520_lanthipeptide
3
P S T L I P I S I A L--------C P T T R C S R R C
23
P+ I P I S I A+ C P T+ C+R C
3
P T I T I P I S I A V S G W I S D K T C P T S V C T R A C
31
41.7%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS13590_lanthipeptide
Lanthipeptides: EL241_RS13590_lanthipeptide
7
I P I S I A L C P T T R C S R R C
23
+P+S I A L C P T +C+ +C
7
V P L S I A L C P T A K C T S K C
23
with 80 more sequence matches
Only the first 10 are displayed here.
39.1%
NZ_CP063142.1 and 1 other:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21460_lanthipeptide
Lanthipeptides: HPB58_RS21460_lanthipeptide
7
I P I S I A L C P T T
17
I P I S+A C P T T
11
I P I S L A A C P T T
21
38.5%
NZ_JFCR01000001.1 and 3 others:
NZ_JFCR01000001.1 Lanthipeptides: JQ44_RS10210_lanthipeptide NZ_JUNC01000006.1 Lanthipeptides: ADC63_RS10380_lanthipeptide NZ_JUNC01000006.1 Lanthipeptides: ADC63_RS10380_lanthipeptide
Lanthipeptides: JQ44_RS10210_lanthipeptide
10
S I A L C P T T R C S R R C
23
S+A L C P T T+C S C
13
S V A L C P T T K C S S A C
26
38.2%
NZ_WIXN01000006.1 and 1 other:
NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide
Lanthipeptides: GHD25_RS06900_lanthipeptide
1
T H P S T L I P I S I A L C P T T R C
19
T H P+T+I P+S+A+C P T T C
7
T H P T T I I P V S L A V C P T T T C
25
37.9%
NZ_CP042598.1 and 3 others:
NZ_CP042598.1 Lanthipeptides: FUT28_RS13815_lanthipeptide NZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11625_lanthipeptide NZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11625_lanthipeptide
Lanthipeptides: FUT28_RS13815_lanthipeptide
4
S T L I P I S I A L C P T T R C S R R C
23
S T++ S I+L C P T T+C+ +C
9
S T I V D A S I S L C P T T K C T S Q C
28
37.9%
NZ_JADPDT010000005.1 and 1 other:
NZ_JADPDT010000005.1 Lanthipeptides: I4V19_RS09875_lanthipeptide
Lanthipeptides: I4V19_RS09875_lanthipeptide
4
S T L I P I S I A L C P T T R C S R R C
23
S T++ S I+L C P T T+C+ +C
9
S T V V E A S I S L C P T T K C T S K C
28
36.7%
NZ_BQME02000001.1 and 5 others:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide
Lanthipeptides: MFF31_RS04085_lanthipeptide
6
L I P I S I A L C P T T R C S
20
+I P I S+A C P T T R C+
8
I I P I S L A A C P T T R C A
22
36.7%
NZ_MJEJ02000054.1 and 3 others:
NZ_MJEJ02000054.1 Lanthipeptides: BH683_RS28810_lanthipeptide NZ_QJSP01000005.1 Lanthipeptides: DFR67_RS30760_lanthipeptide NZ_QJSP01000005.1 Lanthipeptides: DFR67_RS30760_lanthipeptide
Lanthipeptides: BH683_RS28810_lanthipeptide
1
T H P S T L I---P I S I A L C P T T R C S
20
T H P+T+ +S+A L C P T +C+
1
T H P T T I S L A S A L S V A L C P T F K C T
23
35.7%
NZ_CP017762.1 and 3 others:
NZ_CP017762.1 Lanthipeptides: BKP57_RS21840_lanthipeptide NZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptide NZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptide
Lanthipeptides: BKP57_RS21840_lanthipeptide
7
I P I S I A L C P T T R C S R R C
23
+ S I A L C P T C S +C
8
V A A S I A L C P T L A C S S K C
24
35.3%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide
Lanthipeptides: WH45_RS23705_lanthipeptide
3
P S T L I P I S I A L C P T T R C S
20
P+T+I P+S+A+C P T T R C+
9
P A T I I P V S L A I C P T T R C A
26
34.6%
NZ_CP016767.1 and 13 others:
NZ_CP016767.1 Lanthipeptides: BCV50_RS13415_lanthipeptide NZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptide NZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptide NZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07925_lanthipeptide NZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07925_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptide NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23165_lanthipeptide NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23165_lanthipeptide
Lanthipeptides: BCV50_RS13415_lanthipeptide
9
I S I A L C P T T R C S R R C
23
I S C P T T C+R C
12
I S S N T C P T T A C T R A C
26

#### MIBiG 4.0 matches for CORMATOL_RS14310

24.3%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
2
H P S T L I P I S I A L C P T T R C S R R C
23
+ +S A C P T T+C+ R C
16
Q A G V A V G V S A A F C P T T K C T S R C
37
23.1%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
13
L C P T T R C S R R C
23
C P T T+C+ +C
16
F C P T T K C T S K C
26
CORMATOL_RS14315
Leader:
MKKYTKQEWAYTTIGLALGVAVALSLGQGNYMMGA
Core:
L S A F F G I C G Y L L A R K S A R K Q
Core with dehydrations:
L Dha A F F G I Cys G Y L L A R K Dha A R K Q

#### antiSMASH-DB 4.0 matches for CORMATOL_RS14315

100.0%
NZ_CP050134.2 and 3 others:
NZ_EQ973330.1 Lanthipeptides: CORMATOL_RS14315_lanthipeptide NZ_LR134504.1 Lanthipeptides: EL293_RS13090_lanthipeptide NZ_LR134504.1 Lanthipeptides: EL293_RS13090_lanthipeptide
Lanthipeptides: HBA49_RS00780_lanthipeptide
1
L S A F F G I C G Y L L A R K S A R K Q
20
L S A F F G I C G Y L L A R K S A R K Q
1
L S A F F G I C G Y L L A R K S A R K Q
20
28.0%
NZ_VIGJ01000001.1:
Lanthipeptides: FLM44_RS26105_lanthipeptide
2
S A F F G I C G Y L L A R K S A
17
S G+C L L A + A
5
S T L S G V C R T L L A A Q E A
20
20.0%
NZ_CP015405.2 and 1 other:
NZ_CP053228.1 Lanthipeptides: HL650_RS06245_lanthipeptide
Lanthipeptides: A4V09_RS08280_lanthipeptide
2
S A F F G I C G Y
10
+A F F G C +
13
T A F F G T C S F
21
allorf_437242_437442
Leader:
MGVSGSWLYGA
Core:
A F L K L Q L S T C E A W L W R G V G W P C A G A A S L V G W G L L V Q L C R G A C F S I S P S P P N L K P R
Core with dehydrations:
A F L K L Q L Dha Dhb Cys E A W L W R G V G W P Cys A G A A Dha L V G W G L L V Q L Cys R G A Cys F Dha I Dha P Dha P P N L K P R

#### antiSMASH-DB 4.0 matches for allorf_437242_437442

100.0%
NZ_EQ973330.1:
Lanthipeptides: allorf_437242_437442_lanthipeptide
1
A F L K L Q L S T C E A W L W R G V G W P C A G A A S L V G W G L L V Q L C R G A C F S I S P S P P N L K P R
55
A F L K L Q L S T C E A W L W R G V G W P C A G A A S L V G W G L L V Q L C R G A C F S I S P S P P N L K P R
1
A F L K L Q L S T C E A W L W R G V G W P C A G A A S L V G W G L L V Q L C R G A C F S I S P S P P N L K P R
55
50.9%
NZ_LR134504.1:
Lanthipeptides: allorf_1621406_1621576_lanthipeptide
1
A F L K L Q L S T C E A W L W R G V G W P C A G A A S L V G
30
A L K L Q S T C E A W L W R G V G W P C A G A A S L V G
10
A G L K L Q F S T C E A W L W R G V G W P C A G A A S L V G
39
21.8%
NZ_CP050134.2:
Lanthipeptides: allorf_0180903_0181139_lanthipeptide
1
A F L K L Q L S T C E A
12
A F L K L Q L S T C E A
43
A F L K L Q L S T C E A
54
with 3 more sequence matches
16.4%
NZ_JQBU01000033.1 and 1 other:
NZ_JQBV01000009.1 Lanthipeptides: IV76_RS12120_lanthipeptide
Lanthipeptides: IV75_RS14620_lanthipeptide
22
C A G A A S L V G W G L L V Q L C R G A C
42
C A G A+L+ L V+ +G C
11
C A G F A T L M S S I G L V K T I K G K C
31
14.5%
NZ_JACHJQ010000008.1:
Lanthipeptides: allorf_202185_202280_lanthipeptide
6
Q L S T C E A W L W R G V G W P C A
23
++S T C A G +P C A
3
R V S T C A A S R N V G S D Y P C A
20
12.7%
NZ_FNYB01000021.1 and 1 other:
NZ_KB976303.1 Lanthipeptides: allorf_014456_014554_lanthipeptide
Lanthipeptides: allorf_13761_13859_lanthipeptide
1
A F L K L Q L S T C E A W L W R G V G
19
A +L+ +C+ L+R G G
1
A N E E L R Y K S C D G S L Y R G K G
19

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 27.48 out of 30.22
Confidence: strong
Additional weak hits (3):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.48 out of 29.38
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.86 out of 29.65
Confidence: weak
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.97 out of 24.78
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

CORMATOL_RS10555 - Class II
  Cleavage pHMM score: -2.00
  RODEO score: 0
  Monoisotopic mass: 4769.5 Da
  Molecular weight: 4772.4 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4790.5 Da N = 1
    4808.5 Da N = 2
    4826.5 Da N = 3
CORMATOL_RS10565 - Class II
  Cleavage pHMM score: -4.00
  RODEO score: 0
  Monoisotopic mass: 2523.2 Da
  Molecular weight: 2524.9 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2543.0 Da N = 1
CORMATOL_RS14310 - Class II
  Cleavage pHMM score: -3.50
  RODEO score: 0
  Monoisotopic mass: 2399.3 Da
  Molecular weight: 2400.9 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2418.9 Da N = 1
    2436.9 Da N = 2
    2454.9 Da N = 3
    2472.9 Da N = 4
CORMATOL_RS14315 - Class II
  Cleavage pHMM score: -6.30
  RODEO score: 0
  Monoisotopic mass: 2192.2 Da
  Molecular weight: 2193.6 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2211.6 Da N = 1
allorf_437242_437442 - Class II
  Cleavage pHMM score: -7.10
  RODEO score: 0
  Monoisotopic mass: 5802.1 Da
  Molecular weight: 5805.8 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    5823.9 Da N = 1
    5841.9 Da N = 2

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ClgR | Caseinolytic protease gene regulator

NZ_EQ973329.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 846,353 - 867,442 nt. (total: 21,090 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Ligases: synthetase
CORMATOL_RS07990: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002309.2 |  | 0.37 | terpene | cattleyene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000677.5 |  | 0.34 | terpene | cyclooctatin | Streptomyces melanosporofaciens
BGC0001456.3 |  | 0.31 | terpene | isorenieratene | Streptomyces argillaceus
BGC0001911.3 |  | 0.31 | terpene | raimonol | Streptomyces anulatus
BGC0001910.4 |  | 0.30 | terpene | cyslabdan A, cyslabdan B, cyslabdan C | Streptomyces cyslabdanicus
BGC0000664.5 |  | 0.29 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000665.5 |  | 0.29 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0000678.5 |  | 0.29 | terpene | pentalenolactone | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000633.3 |  | 0.28 | terpene | carotenoid | Streptomyces avermitilis
BGC0001227.3 |  | 0.28 | terpene | isorenieratene | Streptomyces collinus Tu 365

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002309.2 |  | 0.37 | terpene | cattleyene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000677.5 |  | 0.34 | terpene | cyclooctatin | Streptomyces melanosporofaciens
BGC0001456.3 |  | 0.31 | terpene | isorenieratene | Streptomyces argillaceus
BGC0001911.3 |  | 0.31 | terpene | raimonol | Streptomyces anulatus
BGC0001910.4 |  | 0.30 | terpene | cyslabdan A, cyslabdan B, cyslabdan C | Streptomyces cyslabdanicus
BGC0000664.5 |  | 0.29 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000665.5 |  | 0.29 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0000678.5 |  | 0.29 | terpene | pentalenolactone | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000633.3 |  | 0.28 | terpene | carotenoid | Streptomyces avermitilis
BGC0001227.3 |  | 0.28 | terpene | isorenieratene | Streptomyces collinus Tu 365

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
CORMATOL_RS07990: PT_FPPS_like
Domain 1 (48 - 332): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.96 out of 30.25
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.01 out of 24.78
Confidence: medium
Additional weak hits (6):
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.05 out of 21.55
Confidence: weak
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.51 out of 23.43
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.68 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.39 out of 29.38
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.28 out of 27.78
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.42 out of 33.14
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ColR | Phenol-responsive regulator
LexA variant 2 | Repressor of DNA damage response

NZ_EQ973328.1 - Region 1 - NI-siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 96,755 - 127,511 nt. (total: 30,757 nt) Show pHMM detection rules used
NI-siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidase
CORMATOL_RS00420: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

CORMATOL_RS00425: FAD linked oxidase domain protein

smcogs
  SMCOG1138: FAD linked oxidase domain protein

CORMATOL_RS00510: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs
  SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: acetyltransferase aminotransferase
CORMATOL_RS00490: GCN5-related N-acetyltransferase

smcogs
  SMCOG1111: GCN5-related N-acetyltransferase

CORMATOL_RS00505: aminotransferase class V

smcogs
  SMCOG1139: aminotransferase class V

Hydrolases: esterase
CORMATOL_RS00550: putative esterase

smcogs
  SMCOG1104: putative esterase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NI-siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002692.2 |  | 0.49 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0001408.5 |  | 0.45 | other (other) | xanthoferrin | Xanthomonas oryzae pv. oryzae KACC 10331
BGC0002527.2 |  | 0.45 | other (other) | vibrioferrin | Azotobacter vinelandii CA
BGC0002733.3 |  | 0.44 | other (other) | sinapigladioside | Burkholderia gladioli
BGC0000734.3 |  | 0.42 | saccharide | capsular polysaccharide | Pasteurella multocida
BGC0000041.3 |  | 0.42 | PKS | oronofacic acid | Pseudomonas syringae
BGC0000794.5 |  | 0.40 | saccharide | S-layer glycan | Geobacillus stearothermophilus
BGC0001410.3 |  | 0.40 | saccharide | polysaccharide A | Bacteroides fragilis
BGC0000783.3 |  | 0.40 | saccharide | O-antigen | Xanthomonas oryzae pv. oryzae
BGC0000772.5 |  | 0.40 | saccharide | lipopolysaccharide | Brucella melitensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002692.2 |  | 0.49 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0001408.5 |  | 0.45 | other (other) | xanthoferrin | Xanthomonas oryzae pv. oryzae KACC 10331
BGC0002527.2 |  | 0.45 | other (other) | vibrioferrin | Azotobacter vinelandii CA
BGC0002733.3 |  | 0.44 | other (other) | sinapigladioside | Burkholderia gladioli
BGC0000734.3 |  | 0.42 | saccharide | capsular polysaccharide | Pasteurella multocida
BGC0000041.3 |  | 0.42 | PKS | oronofacic acid | Pseudomonas syringae
BGC0000794.5 |  | 0.40 | saccharide | S-layer glycan | Geobacillus stearothermophilus
BGC0001410.3 |  | 0.40 | saccharide | polysaccharide A | Bacteroides fragilis
BGC0000783.3 |  | 0.40 | saccharide | O-antigen | Xanthomonas oryzae pv. oryzae
BGC0000772.5 |  | 0.40 | saccharide | lipopolysaccharide | Brucella melitensis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 16.04 out of 18.57
Confidence: medium
Additional weak hits (6):
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 20.53 out of 30.25
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.73 out of 30.25
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.88 out of 26.06
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.84 out of 27.78
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 22.07 out of 30.97
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.88 out of 28.19
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ToxT | Regulator of MSHA biosynthesis

NZ_EQ973328.1 - Region 2 - NRP-metallophore,NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 350,467 - 399,965 nt. (total: 49,499 nt) Show pHMM detection rules used
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
CORMATOL_RS01685: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Hydrolases: esterase hydrolase
CORMATOL_RS01660: enterobactin/ferric enterobactin esterase

smcogs
  SMCOG1098: enterobactin/ferric enterobactin esterase

CORMATOL_RS01680: isochorismatase

smcogs
  SMCOG1027: isochorismatase

Isomerases: isomerase
CORMATOL_RS01675: isochorismate synthase

smcogs
  SMCOG1018: isochorismate synthase

Ligases: ligase
CORMATOL_RS01655: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

CORMATOL_RS01670: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRP-metallophore | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001833.4 |  |  | 0.69 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001132.4 |  |  | 0.65 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002286.3 |  |  | 0.65 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  |  | 0.64 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  |  | 0.64 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001641.4 |  |  | 0.62 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  |  | 0.58 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000342.4 |  |  | 0.58 | NRPS | enniatin | Fusarium equiseti
BGC0001251.4 |  |  | 0.58 | NRPS | epichloenin A | Epichloe festucae
BGC0001250.4 |  |  | 0.58 | NRPS | epichloenin A | Epichloe festucae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001833.4 |  | 0.67 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001132.4 |  | 0.66 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002286.3 |  | 0.66 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.65 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.65 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001641.4 |  | 0.64 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.63 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000342.4 |  | 0.63 | NRPS | enniatin | Fusarium equiseti
BGC0001251.4 |  | 0.62 | NRPS | epichloenin A | Epichloe festucae
BGC0001250.4 |  | 0.62 | NRPS | epichloenin A | Epichloe festucae

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.75 out of 18.57
Confidence: strong
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.79 out of 23.79
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.03 out of 27.78
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.22 out of 18.57
Confidence: strong
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.82 out of 21.84
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.21 out of 27.78
Confidence: medium
Additional weak hits (11):
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.46 out of 20.47
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.23 out of 26.06
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.63 out of 39.62
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.73 out of 27.78
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 20.99 out of 33.14
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 24.69 out of 36.53
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.32 out of 26.06
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 27.05 out of 39.62
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 20.54 out of 31.73
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.30 out of 20.01
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.52 out of 29.65
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 350466 - 399965:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Ser)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
CORMATOL_RS01655: Ser
Search NORINE for peptide: strict or relaxed
AMP-binding (468..849): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    ser (Ser)
  Single AA prediction:
    ser (Ser)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWMTFDVSVWELHFITSGEHNLYGPTEAAIDVTA
  Nearest Stachelhaus code(s):
    Ser DVWHISLIDK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

CORMATOL_RS01670: diOH-Bz
Search NORINE for peptide: strict or relaxed
AMP-binding (26..432): diOH-Bz
nrpys: diOH-Bz

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Small clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Single AA prediction:
    dhb (diOH-Bz)

Stachelhaus prediction details:
  Stachelhaus sequence:
    SESLFTMSSPGGALQVGGAQQVFGMAEGLVNYTR
  Nearest Stachelhaus code(s):
    diOH-Bz TMPSQGVVNK (94% 8Å match)
  Stachelhaus code match:
    90% (moderate)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
IolR | Regulator of the inositol catabolism
MexT | Global virulence regulator
ToxT | Regulator of MSHA biosynthesis

NZ_EQ973328.1 - Region 3 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 576,248 - 597,117 nt. (total: 20,870 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
CORMATOL_RS02610: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

CORMATOL_RS02650: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs
  SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: transferase
CORMATOL_RS02580: acetyl-CoA carboxylase, carboxyl transferase,

smcogs
  SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

Hydrolases: hydrolase
CORMATOL_RS02605: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

Translocases: transporter
CORMATOL_RS02640: sugar-binding lipoprotein

smcogs
  SMCOG1143: sugar-binding lipoprotein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000650.3 |  | 0.50 | terpene | carotenoid | Algoriphagus sp. KK10202C
BGC0000637.3 |  | 0.48 | terpene | carotenoid | Corynebacterium glutamicum
BGC0000645.3 |  | 0.45 | terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0001553.5 |  | 0.43 | NRPS, PKS | clifednamide A | Streptomyces sp. JV178
BGC0000636.3 |  | 0.43 | terpene | carotenoid | Brevibacterium linens
BGC0002150.2 |  | 0.42 | ribosomal | triculamin | Streptomyces triculaminicus
BGC0002151.2 |  | 0.42 | ribosomal | alboverticillin | Streptomyces griseocarneus
BGC0000664.5 |  | 0.42 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000630.3 |  | 0.41 | terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis
BGC0000649.3 |  | 0.40 | terpene | carotenoid | Streptomyces griseus subsp. griseus NBRC 13350

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000650.3 |  | 0.50 | terpene | carotenoid | Algoriphagus sp. KK10202C
BGC0000637.3 |  | 0.48 | terpene | carotenoid | Corynebacterium glutamicum
BGC0000645.3 |  | 0.45 | terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0001553.5 |  | 0.43 | NRPS, PKS | clifednamide A | Streptomyces sp. JV178
BGC0000636.3 |  | 0.43 | terpene | carotenoid | Brevibacterium linens
BGC0002150.2 |  | 0.42 | ribosomal | triculamin | Streptomyces triculaminicus
BGC0002151.2 |  | 0.42 | ribosomal | alboverticillin | Streptomyces griseocarneus
BGC0000664.5 |  | 0.42 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000630.3 |  | 0.41 | terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis
BGC0000649.3 |  | 0.40 | terpene | carotenoid | Streptomyces griseus subsp. griseus NBRC 13350

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene |  | PSPP | C30 | acyclic | PP
triterpene | C30 carotenoid | diapophytoene | C30 | acyclic | none
triterpene |  | squalene | C30 | acyclic | none
tetraterpene | C40 carotenoid | phytoene | C40 | acyclic | none
triterpene |  | hydroxysqualene | C30 | acyclic | OH

Genes with terpene domains:
CORMATOL_RS02615: PT_phytoene_like
Domain 1 (2 - 265): Prenyltransferase; Phytoene synthase like
Subtype: unknown

Reactions:
  FPP → PSPP
  FPP → diapophytoene
  FPP → squalene
  GGPP → phytoene
  PSPP → hydroxysqualene

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.82 out of 21.84
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.87 out of 30.25
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.06 out of 19.26
Confidence: strong
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.98 out of 27.55
Confidence: medium
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 24.83 out of 29.65
Confidence: medium
Additional weak hits (9):
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.31 out of 25.75
Confidence: weak
RicR
Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.62 out of 32.93
Confidence: weak
RicR
Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.72 out of 32.93
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 20.55 out of 30.25
Confidence: weak
CsoR
Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 24.12 out of 32.38
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.89 out of 29.65
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 18.85 out of 28.14
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.37 out of 28.14
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 19.22 out of 28.14
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
FPP | Farnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
PP | Diphosphate
PSPP | Presqualene diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
ColR | Phenol-responsive regulator
GnfM | Regulator of nitrogen-fixation genes
LexA variant 1 | Repressor of DNA damage response
MexT | Global virulence regulator

NZ_EQ973328.1 - Region 4 - NRPS,NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 723,099 - 770,261 nt. (total: 47,163 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: halogenase
CORMATOL_RS03240: halogenase

smcogs
  SMCOG1119: halogenase

Hydrolases: phosphatase
CORMATOL_RS03160: inositol monophosphatase

smcogs
  SMCOG1207: inositol monophosphatase

CORMATOL_RS03165: inositol monophosphatase

smcogs
  SMCOG1207: inositol monophosphatase

Ligases: ligase
CORMATOL_RS03245: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

CORMATOL_RS03290: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

CORMATOL_RS13555: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

CORMATOL_RS14650: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

CORMATOL_RS14655: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001251.4 |  |  | 0.70 | NRPS | epichloenin A | Epichloe festucae
BGC0001250.4 |  |  | 0.70 | NRPS | epichloenin A | Epichloe festucae
BGC0001833.4 |  |  | 0.66 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0000307.4 |  |  | 0.57 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001160.5 |  |  | 0.45 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001164.3 |  |  | 0.45 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001876.2 |  |  | 0.43 | NRPS | thalassospiramide A | Thalassospira sp. CNJ-328
BGC0000351.5 |  |  | 0.42 | NRPS | exochelin | Mycolicibacterium smegmatis MC2 155
BGC0002765.2 |  |  | 0.38 | NRPS | Keanumycin A, Keanumycin B, Keanumycin C | Pseudomonas sp. QS1027
BGC0002158.2 |  |  | 0.37 | NRPS, PKS | tenuazonic acid | Pyricularia oryzae 70-15

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001251.4 |  | 0.68 | NRPS | epichloenin A | Epichloe festucae
BGC0001250.4 |  | 0.68 | NRPS | epichloenin A | Epichloe festucae
BGC0001833.4 |  | 0.66 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0000307.4 |  | 0.62 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001160.5 |  | 0.55 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001164.3 |  | 0.55 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001876.2 |  | 0.54 | NRPS | thalassospiramide A | Thalassospira sp. CNJ-328
BGC0000351.5 |  | 0.54 | NRPS | exochelin | Mycolicibacterium smegmatis MC2 155
BGC0002765.2 |  | 0.51 | NRPS | Keanumycin A, Keanumycin B, Keanumycin C | Pseudomonas sp. QS1027
BGC0001843.2 |  | 0.51 | NRPS | tridecaptin M | Paenibacillus sp. M-152

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.22 out of 18.46
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.24 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.29 out of 27.78
Confidence: medium
NrdR
Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 22.14 out of 27.18
Confidence: medium
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.56 out of 20.47
Confidence: medium
Additional weak hits (8):
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.13 out of 25.75
Confidence: weak
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.93 out of 27.55
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.91 out of 28.14
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.06 out of 26.33
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 27.38 out of 39.62
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.12 out of 30.98
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.79 out of 26.85
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.56 out of 33.14
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 4, location 723098 - 770261:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X) + (Ala)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 5, location 723098 - 766986:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X) + (Ala)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 6, location 727957 - 770261:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X) + (Ala)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
CORMATOL_RS03245: Ala
Search NORINE for peptide: strict or relaxed
AMP-binding (492..872): Ala
nrpys: Ala

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Small clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Single AA prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:
  Stachelhaus sequence:
    NDLSFDMSIFEGNSVLGGDDVLGGATEASIHSTF
  Nearest Stachelhaus code(s):
    Ala DMFNVGLIHK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

CORMATOL_RS14655: X
AMP-binding (214..586): X
nrpys: Val, Leu, Ile, Abu, Ival

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    HAATFDISLDELHGIVGGERNVYGPTEATIWATE
  Nearest Stachelhaus code(s):
    Gly DILQLGVIWK (68% 8Å match)
  Stachelhaus code match:
    70% (weak)

CORMATOL_RS13555: NH2
CAL_domain (145..454): NH2
minowa: NH2

Prediction, score:
  NH2: 48.5
  Acetyl-CoA: 33.7
  shikimic_acid: 0.0
  fatty_acid: 0.0
  AHBA: 0.0

CORMATOL_RS03290: X
AMP-binding (28..400): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    IKDHWTFAQLKPESLNTYD--------AAIWLHS
  Nearest Stachelhaus code(s):
  Stachelhaus code match:
    0% (weak)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
NrdR | Represses ribonucleotide reductase encoding genes
RpoN | Regulator of nitrogen assimilation and virulence
VqsM | Regulator of quorum-sensing signalling systems