LOCUS       NZ_CAKMXI010000016     10228 bp    DNA     linear   CON 03-JUN-2024
DEFINITION  Streptomyces atroolivaceus strain TUE2108, whole genome shotgun
            sequence.
ACCESSION   NZ_CAKMXI010000016
VERSION     NZ_CAKMXI010000016.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces atroolivaceus
  ORGANISM  Streptomyces atroolivaceus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 192723)
  AUTHORS   Wibberg,D.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-FEB-2022) CEBITEC, Genome Research of Industrial
            Microorganisms (GRIM), Universitaetsstrasse 27, 33615, NRW, Germany
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_928722305.1-RS_2024_06_03
            Annotation Date                   :: 06/03/2024 04:23:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,057
            CDSs (total)                      :: 6,983
            Genes (coding)                    :: 6,683
            CDSs (with protein)               :: 6,683
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 2 (5S, 16S)
            complete rRNAs                    :: 1, 1 (5S, 16S)
            partial rRNAs                     :: 1 (16S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 300
            CDSs (without protein)            :: 300
            Pseudo Genes (ambiguous residues) :: 0 of 300
            Pseudo Genes (frameshifted)       :: 123 of 300
            Pseudo Genes (incomplete)         :: 254 of 300
            Pseudo Genes (internal stop)      :: 20 of 300
            Pseudo Genes (multiple problems)  :: 87 of 300
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:59:12
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 112088
            Orig. end                         :: 122316
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CAKMXI010000016.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10228
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10228
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10228
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5228](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5228
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(350..793)
                     /locus_tag="NBY68_RS31030"
     CDS             complement(350..793)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014044486.1"
                     /locus_tag="NBY68_RS31030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_250293779.1"
                     /transl_table=11
                     /translation="MRSARTLFASAAVTAVLAVSVPAAYAVTSADDWDKDSGSSASSND
                     DREKPDSWKHEKPEGGVHAGGGALAGLSADDWEKDKDWNSGSNTDSEKTWKHEKPEGGV
                     HTGGGAMALSGSGLAAGSVLMLGGVGAVAYKLRRRSASGAAAV"
     gene            complement(1219..1476)
                     /locus_tag="NBY68_RS31035"
     CDS             complement(1219..1476)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NBY68_RS31035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_250293838.1"
                     /transl_table=11
                     /translation="MSFDAAAAAEAAQVLLNACAVLAPKLATPALCLPTVRDGLDEFRR
                     VYGARGDEALLVRPDGHLGLRVTPASSPELPAHLAMLFGR"
     gene            complement(1526..4222)
                     /locus_tag="NBY68_RS31040"
     CDS             complement(1526..4222)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_function="GO:0030246 - carbohydrate binding [Evidence
                     IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005310756.1"
                     /locus_tag="NBY68_RS31040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cellulose binding domain-containing protein"
                     /protein_id="WP_348538883.1"
                     /transl_table=11
                     /translation="MRFSARPIAALLAALALTAGLSVTGTPAVARPDERPAAAEASDVS
                     IAADTYTWKNARIDGGGFVPGIVFNRSEKNLAYARTDIGGAYRWDQTGKQWKPLLDWVD
                     WDRWGWSGVVSLASDTAEPDNVYAAVGTYTNSWDPTNGAVLRSSDRGASWKAATLPFKL
                     GGNMPGRGMGERLAVDPNKNSVLYLGAPSGHGLWRSTDSGVTWSEVTAFPNPGNYAQDP
                     SDTSGYGNDNQGIVWVTFDERSGSAGGATQDIYVGVADKENTVYRSTDGGSTWSRIAGQ
                     PTGYLAHKGVLDSATGHLYLTLSDTGGPYDGAKGQIWRYDTGSGAWTDVSPVAEADTYY
                     GFSGLSVDRQKPGTLMATAYSSWWPDTQIFRSTDSGATWTQAWDYTSYPTRSNRYTLDV
                     SSVPWLSWGANPSPPETAPKLGWMTESLEIDPFDSNRMMYGTGATVYGTENLTSWDTGG
                     QFKITPMVKGLEETAVNDLASPPSGAPLLSALGDIGGFRHTDLDAVPAMMFTSPNLDST
                     TSLDFAEASPGTVVRVGNADAAPHIGFSTDNGANWFQGSEPAGVTGGGTVAAAADGSGF
                     VWSPDGAAVHRTTGYGSSWTASTGIPAGATVESDRKNPKKFYGFKAGTFYVSTDGGATF
                     AAKANGLPAEGNVRFKALPGSEGDIWLAGGASTGAYGLWRSTDSGTSFTKFSGVEQADS
                     VGFGKAASGASYQTVFVSAKIGGVRGVFRSTDAGANWTRINDDAHQWAWTGAAITGDPR
                     VYGRVYVSTNGRGIQVGESSDTGGGGTDPDPDPTDPPADADCSVTYKVTNRWSGGFQAE
                     VTVTNTGSTAYDGWQLGWSFAGDQKVTQMWNASHRQDGAKVTATNVGWNGKVAPGSSAG
                     FGFTGTSTGGSTDPNAFTLGGEACTVG"
     misc_feature    complement(4281..4295)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 30.11"
                     /tool="antismash"
     misc_feature    4282..4296
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 28.65"
                     /tool="antismash"
     misc_feature    complement(4521..4535)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.75"
                     /tool="antismash"
     misc_feature    4894..4909
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.69"
                     /tool="antismash"
     gene            5001..5228
                     /locus_tag="NBY68_RS31045"
     CDS             5001..5228
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014157700.1"
                     /locus_tag="NBY68_RS31045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type A2 lantipeptide"
                     /protein_id="WP_250293780.1"
                     /sec_met_domain="strepbact (E-value: 4.5e-32, bitscore:
                     103.8, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNYTPQVETAEISDSDLDNVSGGLVGNVLGNVTGTVEGIVPVAGV
                     DGSVTGLVESATGVNTGAVTGLAGGLTAGL"
     gene            5312..6118
                     /locus_tag="NBY68_RS31050"
     CDS             5312..6118
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386622.1"
                     /locus_tag="NBY68_RS31050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_250293781.1"
                     /transl_table=11
                     /translation="MQFRQQALSKLQSPEQLDLPVRFARPQGLLVLCVTVVVMAAACFW
                     AATGSVASTIEAPGILTHSRGSYVLQSPVAGQITEVLAEEGETLPRNSPLLKVRTEQGE
                     RVVRTIDAGRLTSVTATIGAVVTTGADVASVERIDGADDPLVVLLYVSGSSAASVPVGA
                     SVDLTVQSVPAQQYGVLRGKVAAVGRAAQTQQQIARFLGDAQLGKQFSEDGRPSAVLVR
                     IERSDSTESGYRWSSAEGPPYAIGSMTLATGSIRLADQHPIDWLLP"
     gene            6115..8388
                     /locus_tag="NBY68_RS31055"
     CDS             6115..8388
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014157698.1"
                     /locus_tag="NBY68_RS31055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_250293782.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 3.6e-38, bitscore:
                     123.7, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPHPSPTAQQLPPPGRGRHRPEGAPGNRRRSRPAPKPGRTKTV
                     RTPTVLQMEALECGAASLAMVLGHHGRHVPLEELRIACGVSRDGSRASNVLKAARGYGL
                     QAKGMQMEPAALAEVQAPAILFWEFNHYVVYDGMGRRLGRRGVHINDPDKGRRFVPTED
                     FDTSFTGVVLVLEPGADFRRGGRKPGVMASLPARLRGTTGTMLVALLASLLLVAVGATL
                     PALSRTYIDMFMIGEQTSLLGVLFAAMGTMVALTVVLTWLQQANLLRGRIISSTLGSAR
                     FFRHLLRLPVTFFSQRSPADLVQRLQSNDAVAETLARDLTAAGVDGIVVLLYAFLLWTY
                     DPQLTVIGVGIALLNVVAMRIVVRLRATGTQKLRADSARLTNTSYTGLQLIETMKATGG
                     ENGYFRRWAGQHATTLEEQQRLGVPSAWLGIVAPALATVNSALILWIGGLRAVEGHISI
                     GLLVAFQALVTRFTAPVTRLNGVAGRIQDFAADVARLKDVENFPVDALYSRPEPAASTR
                     RLKGHVTLEEITFGYSPLDKPLLTGFSLSVGPGQQVALVGGSGSGKSTVSRLISGLYSP
                     WEGTIRIDGQRLEDIPRGALAASVSFVDQDVFLFEGTVRDNVALWDPSVPDEAVAEALR
                     DAALYDVVARRPRGIHSRVEQDGRNFSGGQRQRLEIARALVRRPSILVLDEVTSALDAE
                     TERVIIDNLRRRGCACVVIAHRLSTVRDSDEIVVLDHGTVVERGRHENLVAAGGPYAEL
                     VREH"
     misc_feature    complement(9489..9504)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.99"
                     /tool="antismash"
ORIGIN
        1 cggggcatcc cgagtggagc ggcggaggcg gaccccgacg gggtggccga ggcaggtgcc
       61 gaggccgcgg ggagggatac gacggccggg gcgggcggga ctcccgccga cgcgtcgaag
      121 gagctgtata cgaggaggaa gcccaggccc accgccgcga cgggccacag cagggaacgg
      181 ccgagggcag gggcggcggt gtctggatcg gacggctgcg gggcggccat gcgcatgctg
      241 cctttcgcgt acgggaggaa cgggcggctg tgcggggaaa tcggcgcggc caccgccccc
      301 ggaaaggggc ggcggccacg acacaggtcg ttcagcggtg ggtggccggt cagacggccg
      361 cggcacccga agcgctgcgg cggcgcagct tgtacgccac ggcgcccacg cctccgagca
      421 tcagcaccga accggcggcc aggccgctgc cggagagcgc catcgctcca ccgccggtgt
      481 ggacaccgcc ctcgggcttc tcgtgcttcc aggtcttctc gctgtccgtg ttgctgccgg
      541 agttccagtc cttgtccttc tcccagtcgt cggccgacag accggccagc gcaccgccac
      601 cggcgtgcac accgccctcg ggcttctcgt gcttccacga gtccggcttc tcacggtcgt
      661 cgttgctgct ggcggaggaa ccgctgtcct tgtcccagtc gtccgccgat gtcacggcgt
      721 aagcggcggg gacggagacc gcgaggaccg ccgtgacggc ggccgatgcg aacagggtgc
      781 gggcagagcg catggataca cagtcctttc gccacccccg cgctggccgg ctggttgtcg
      841 gctcatcgga tcacgggtgc gacgtgatcc accgtcagcc gaaatccgga ggcgcaccac
      901 tcgggaaggg cgcaatcgag cgacgcggtg ggctcatcgt gtgacaggga gccagatgtc
      961 acccgttgga cggcacgcca cgccgggggg aggtttggga caggacgatc atccgggtaa
     1021 ggggcctctg cgctcgcggg gatcatggcg tgggcgacac ggcgacacga tcatcgacca
     1081 cacctgggtg gggcgcgccg accacggcga gggcgccggc cgggaggcca accgcgtcga
     1141 cggacggcgc ggggcccggc aggagcccct gcggggccgc gcatcgggtc ggcggctcgt
     1201 ccccgcccct cccctccgtc acctcccgaa aagcatggcc aggtgtgcgg ggagttccgg
     1261 gctcgaagcc ggggtgacac gcagtccgag atgaccgtcc ggccgtacga ggagcgcctc
     1321 gtcgccccgc gcgccgtaca cacggcggaa ctcgtcgagg ccgtcccgca cggtgggcag
     1381 gcacagtgcg ggcgtggcca gcttcggggc gagcaccgcg caggcgttca gcagaacctg
     1441 cgccgcctcc gctgccgcag ccgcatcgaa tgacacgcgt gggccggcgc ggggaggaac
     1501 cgctccccgc gccggcccac gggcctcagc cgacggtgca ggcctcaccg cccagagtga
     1561 aggcgttcgg atcggtgctg ccgcccgtgg acgtgccggt gaagccgaag cccgccgagg
     1621 agccgggcgc caccttgccg ttccagccga cgttcgtcgc ggtcaccttc gccccgtcct
     1681 ggcggtggga ggcgttccac atctgggtga ccttctggtc tcccgcgaag gaccagccca
     1741 gctgccagcc gtcgtaggcg gtgctgccgg tgttggtgac cgtcacctcg gcctggaagc
     1801 cgccggacca ccgattggtg accttgtacg tcaccgagca gtcggcgtcc gccggcgggt
     1861 cggtcgggtc ggggtccggg tccgtgcctc cgccaccggt gtcggaggac tcgccgacct
     1921 ggattccccg gccgttcgtg gagacgtaca cccggccgta gacccggggg tccccggtga
     1981 tcgccgcgcc ggtccatgcc cactggtgcg cgtcgtcgtt gatccgcgtc cagttggcgc
     2041 ccgcgtccgt ggaccggaag acgccgcgta ccccgccgat cttcgcgctg acgaagacgg
     2101 tctggtacga ggccccggaa gccgccttgc cgaagccgac gctgtcggcc tgttccacgc
     2161 cggagaactt ggtgaagctc gtgccggagt cggtggagcg ccagagcccg tacgcacccg
     2221 tcgaggcgcc gccggcgagc cagatgtcgc cctccgagcc gggaagggcc ttgaagcgca
     2281 cgttgccttc tgcgggcagc ccgttcgcct tcgcggcgaa cgtggctccg ccgtcggtcg
     2341 acacgtagaa cgtgccggcc ttgaacccgt agaacttctt cgggttcttc cggtccgact
     2401 cgaccgtcgc ccccgccggg atccccgtgg aggcggtcca ggaactgccg taaccggtgg
     2461 tgcggtggac ggccgctccg tccggactcc agacgaaccc gctgccgtcc gccgcggcgg
     2521 cgaccgtgcc gccgccggtg accccggcgg gctcggagcc ctggaaccag ttggcaccgt
     2581 tgtcggtgga gaagccgatg tgcggagcgg cgtcggcgtt gcccacccgt acgaccgtgc
     2641 cgggggaagc ttccgcgaag tcgaggctgg tggtggagtc gaggttcggc gaggtgaaca
     2701 tcatggcggg caccgcgtcg aggtcggtgt gccggaagcc cccgatgtca ccgagagcgc
     2761 tcagcagggg cgcgccggag ggcgggctcg ccaggtcgtt gacggccgtc tcctcgagcc
     2821 ccttgaccat gggcgtgatc ttgaactggc caccggtgtc ccaggacgtg aggttctcgg
     2881 tgccgtacac cgtcgcgccc gtgccgtaca tcatccggtt cgagtcgaac gggtcgatct
     2941 ccagggactc cgtcatccag cccagcttgg gcgcggtctc cggcggggac gggttggcgc
     3001 cccagctgag ccagggcacg gaggagacgt ccagggtgta gcggttggag cgggtcgggt
     3061 agctcgtgta gtcccacgcc tgtgtccatg tcgcaccact gtccgtggaa cggaagatct
     3121 gggtgtcggg ccaccaggag ctgtaggcgg tcgccatcag cgtcccgggc ttctgccggt
     3181 cgacggagag gccgctgaac ccgtagtagg tgtcggcctc cgcgacggga ctgacgtccg
     3241 tccacgcacc ggaccccgtg tcgtaccgcc agatctgccc cttggccccg tcgtacgggc
     3301 cgcccgtgtc actcagcgtc aggtagaggt ggcccgtcgc ggagtcgagt acgcccttgt
     3361 gcgcgaggta tccggtcggc tggccggcga tcctggacca ggtgctgcca ccgtccgtgg
     3421 agcggtagac ggtgttctcc ttgtcggcca ctccgacgta gatgtcctgg gtggcgccgc
     3481 ccgcgctgcc cgaacgctcg tcgaaggtca cccatacgat gccctggttg tcgttgccgt
     3541 atccgctggt gtcggacggg tcctgcgcgt agttgccggg attggggaag gcggtcacct
     3601 ccgaccaggt gacccccgag tcggtggacc gccacagccc gtggccgctg ggggcaccga
     3661 ggtacagcac ggagttcttg ttggggtcga cggcgagccg ctcccccatc cctcgtcccg
     3721 gcatgttgcc gccgagcttg aagggcagcg tggccgcctt ccaggacgcg ccgcggtccg
     3781 aggaacgcag gaccgcgccg ttggtcgggt cccagctgtt ggtgtaggtg ccgacggcgg
     3841 cgtacacgtt gtcgggctcg gccgtgtcgg aggcgagact caccacacct gaccagcccc
     3901 accggtccca gtccacccag tccagcagcg gcttccactg cttgcccgtc tggtcccagc
     3961 ggtacgcacc gccgatgtcg gtgcgcgcgt aggccaggtt cttctcggac cggttgaaga
     4021 cgatgcccgg tacgaaaccg ccaccgtcga tccgcgcgtt cttccaggtg taggtgtccg
     4081 ccgcgatgga cacatccgat gcttcggccg cggcgggcct ttcgtccggc cgtgccacgg
     4141 ccggggtgcc ggtgaccgac aacccggcgg tgagggcaag tgccgccagt agggcggcga
     4201 ttggtctggc gctgaagcgc acggaaacgt cctctccgag ctggaccgcc gcacggcggc
     4261 ggtacgggac tgacacagag atgggagcgc tcccacaagg catcccgatg gtagcgccgc
     4321 gcgtcgcccc agagaagggt gatgcagtcg gttcatcgga tgaatcaagt caactccctt
     4381 gcgggccacc cccgtacggc ccgagggcgc gcattccaca ccctcggcaa cccgaaaggg
     4441 cgcaccgaag ggctcacacc ttctccatat atccgcaggc ggcgtgacac gttgaacacg
     4501 cggaaccaga aaccgcttca tgaacacgcc attcattcgc aggcggagac caagaaaaag
     4561 agaaacacgc tcacctttca caatggcgtg aataccgata cctgccgaac tccgccgagc
     4621 cacccgcccc acccgcgccc ggaattacca ggcagccgga tcggtgaaac ctgcacacgg
     4681 catgcgcaca ccggtcacgc gactcggcac gaaccaccag gtccggaggg gggtgggggg
     4741 cgattggggc gggagtgccc cacttgggag gcgtggggtt gcggtgacac ggaattcatc
     4801 cggtgaagct cgtgaaggat ctgccgccac ggaatgaaca cttctgcacg taagtcgatt
     4861 gcagcgggcc gataaccaca gatccgccgt agttcgattg gctgtacgag gcggaggcgt
     4921 gctttgatcc tgggccatac ggaggccgca acacggggtc ccgtatataa gaagtttcca
     4981 tacgaagggc agcgctcatc atgaactaca ccccccaggt cgagaccgcc gagatctccg
     5041 acagcgacct cgacaacgtc tcgggcggcc tcgtcggcaa cgtgctcggc aacgtcacgg
     5101 gcaccgtcga gggcatcgtc ccggtcgccg gcgtcgacgg ctcggtcacc ggtctcgtgg
     5161 agtccgccac cggtgtgaac acgggcgcgg tcaccggcct ggccggcggc ctgaccgccg
     5221 gtctctgaga cacggcagta ccccaccgag ccccggaacc cgtcggttcc ggggctcggt
     5281 gccgaccgct gacaggtgag ggaagagttc cgtgcagttc cgccaacagg ccctttccaa
     5341 gctgcagtca cccgaacagc tcgaccttcc ggtgcgcttc gcccgcccac agggcctgct
     5401 cgtcctctgc gtcaccgtcg tcgtgatggc cgcagcctgc ttctgggcag cgacgggctc
     5461 ggtcgccagc acgatcgaag cgccgggcat cctcacccat tcgcgcggca gttacgtcct
     5521 gcagagcccc gtcgccggac agatcaccga ggtgctcgcc gaggagggcg agacgctgcc
     5581 ccggaactcc cccttgctca aggtccgtac ggagcaggga gaacgcgtcg tccgtacgat
     5641 cgacgcgggc cggctcacct ccgtgacggc cacgatcggc gcggtggtca ccacgggtgc
     5701 ggacgtggcg agcgtcgaac ggatcgacgg cgccgacgat ccactcgtcg tcctgctgta
     5761 cgtgtccggc agcagtgccg cgtctgtccc ggtgggcgcc tccgtcgacc tcaccgtcca
     5821 gtccgtgccc gcccagcagt acggggtact gcgcggcaag gtggctgcgg tcggcagggc
     5881 cgcgcagacc cagcagcaga tcgcccgctt cctcggcgac gcccagctcg gcaagcagtt
     5941 ctccgaggac gggcggccgt cggcggtgct ggtgcgcatc gagcgctcgg actcgaccga
     6001 gtccggctac cggtggtcct cggccgaggg ccctccgtac gcgatcggct ccatgaccct
     6061 ggccaccggc tccatccgtc tcgccgacca gcaccccatc gattggctgc tcccgtgacc
     6121 gccccgcacc cgtcccccac cgcccagcag ctgccgcccc cgggccgcgg caggcaccgc
     6181 ccggaggggg ccccgggcaa caggcggcgg tcacgtcccg caccgaagcc cggacggacg
     6241 aagaccgtac gcactcccac ggtgctccag atggaggccc tggagtgcgg cgcggcctca
     6301 ctggcgatgg tcctcggtca ccacggccgc cacgtgccgc tggaggagct gcggatcgcg
     6361 tgcggcgtct cgcgggacgg ctcacgcgcc agcaacgtgc tcaaggcggc ccgcggttac
     6421 ggtctccagg ccaagggcat gcagatggag cccgcggcac tggcggaggt ccaggcgccc
     6481 gcgatcctgt tctgggagtt caaccactac gtcgtgtacg acggcatggg acgccggctc
     6541 ggacggcgag gcgtgcacat caacgatccc gacaagggcc gccggttcgt ccccaccgag
     6601 gacttcgaca ccagcttcac gggggtcgtc ctcgtcctcg aacccggcgc ggacttccgt
     6661 cgcggcggcc ggaagcccgg cgtcatggca tcgcttccgg cccggctgcg cggcaccacg
     6721 ggcacgatgc tggtcgctct gctcgccagc ctgctgctgg tggccgtcgg ggcgacgctc
     6781 ccggccctga gccgtaccta tatcgacatg ttcatgattg gcgagcagac ctcgctgctg
     6841 ggcgtgctgt tcgccgcgat gggcaccatg gtcgcgctga ccgtcgtact gacgtggctg
     6901 cagcaggcga atctgctgcg cgggcgcatc atctcctcga cgctgggcag cgcgcgcttc
     6961 ttccggcacc tgctccggct gcccgtcacc ttcttctcgc agcgcagccc cgccgacctc
     7021 gtccagcgcc tccagtcgaa cgacgccgtg gccgagacgc tcgcccggga tctcaccgcg
     7081 gccggggtgg acggcatcgt cgtcctgctc tacgcgttcc tgctgtggac gtacgatccg
     7141 cagctgaccg tgatcggggt ggggatcgcg ctgctcaacg tcgtcgcgat gcgcatcgtc
     7201 gtacggctga gggccaccgg cacccagaag ctgcgtgcgg acagcgcacg gctgacgaac
     7261 acctcgtaca ccggcctcca gctgatcgag acgatgaagg ccaccggtgg ggagaacggg
     7321 tacttccgcc ggtgggccgg acagcacgcg acgacgctgg aggagcagca gcgcctcggg
     7381 gtgccgagtg cctggctggg catcgtcgcc cccgccctcg ccacggtcaa cagcgctctg
     7441 atcctgtgga tcggcgggct gcgggccgtc gaggggcaca tctccatcgg tctgctcgtc
     7501 gcgttccagg cgctggtgac ccgcttcacc gcgccggtca cccggctcaa cggggtggcg
     7561 ggccggatcc aggacttcgc ggccgacgtg gcccgcctca aggacgtcga gaactttccg
     7621 gtcgacgcgc tgtactcccg ccctgaaccg gccgcgagta cccgtcggct caagggccac
     7681 gtgacgctgg aggagatcac cttcggttac agcccgctcg acaagcccct gctcaccggt
     7741 ttctccctgt ccgtgggccc gggtcagcag gtggccctcg tcggcggctc gggcagcggc
     7801 aagtcgacgg tctcccggct catctcgggg ctctacagtc cctgggaggg cacgatccgc
     7861 atcgacggac agcgtctgga ggacataccc cggggtgcgc tggccgcctc cgtctccttc
     7921 gtcgaccagg acgtcttcct cttcgagggc acggtccggg acaacgtcgc cctgtgggat
     7981 ccctcggtcc cggacgaggc cgtggccgaa gcgctgcggg acgccgccct gtacgacgtc
     8041 gtcgcccgcc gcccccgcgg catccacagc cgggtggagc aggacggccg gaacttctcc
     8101 ggcgggcagc gtcagcgcct ggagatcgcc cgcgcactcg tgcgccggcc cagcatcctg
     8161 gtcctggacg aggtcaccag cgcgctggac gccgagaccg agcgcgtcat catcgacaac
     8221 ctgcggcggc gcggctgcgc ctgtgtcgtg atcgcgcacc ggttgagcac cgtgcgcgac
     8281 agcgacgaga tcgtggtcct ggaccacggg accgtcgtgg agcgcggccg gcacgagaat
     8341 ctggtggccg ccgggggccc gtacgccgaa ctggtcaggg agcactgacg tggcatccgt
     8401 acatccggtc gcgggcacgg aggcccccgg gcaggacccg gtcatggccg cgctgggcgc
     8461 tctcgggcgg ccggtcgact gcaccggact gcgaagcctg tcgctggaag ggccccaggt
     8521 cctgtggctc gtcgtgggcg gcgccctcga cctgttcgcg gtggacgcgg cggagcaggg
     8581 ccactggcac ttcctgggcc ggctcgaacc tggaaccctc gtgctgggtc cggtcgaggg
     8641 cccgcagcac accctggtcg gacgccccct ccaggagtgc gtgctgcggc ggatcccgct
     8701 gcgggagctg taccggccgg agtacgacgg ccaggcggcg tacgagacgc agtaccgcag
     8761 ccactacgac accggggacg ccacgctgag cctgttggag cacgccttct cgctcggtgt
     8821 gggccgcagt cagcgcgtgc tgttcgaggc cccgctggac gggcggacca ccctcgacga
     8881 aacggtgggc gacgacgaca tcctgtggct gccggtgtcc cccggcagtg tgcagtacgg
     8941 cgccgcgttc agcgccgagg cggcgggtga cctcctcgtc gacccggcga tgtggcaggg
     9001 gatggtcaat cagcagtacc gcctgctgtc cgcgctcgac cgctggatcg aacagctgga
     9061 gcgcgctcac gaggaccgga ccgccgcagg catgaaggcc ggcgaggcgg tccgcaggga
     9121 ggccgaccag gccctgctga cctcgatcgg gaggtccggg agaggcactt cacccgcctc
     9181 cggcgcctcg gacgacgcgg tgtacgcggc ctgccgtctg gtggcccggg attccgggat
     9241 cgtcctggct gagcccgcga cgggtggggc ggtgagcgac cggatcgatc cggtcgaacg
     9301 tgtggcggtc gcctcgcgca tccgcacccg cccggtgcgg ctcgacgggc gctggtggcg
     9361 ggagaactca gggccgctgg tgggacaccg ggccgcatcc ggagcgccgg tcgccctgct
     9421 ctggcggcgg ggccgctacg aggcggtcaa cccgctgacc gggcggcgca gccgtgtcga
     9481 cggcgattcc gcgcaggagt tcgacgagcg cgccgtgatg ttctaccggc cactgccgga
     9541 gcagccgttg agcaggaggc agctcctgcg cttcggcctg ttcggcaccc ggggcgacct
     9601 gcggaatctg gtactggcgg gactggtgac ggtcgcactg gggtcgctgg tgccgatcgc
     9661 gaccggcaag gtgctcggcg tgtacgtgcc caacgcccag aacgccctca tcgtgcaggt
     9721 gtcactggcc gtcatcatct ccggtgtcgt ctcggcggcc ttcatgctgc tgcagaacct
     9781 cacgatcctg cggatggaag ggcggatcga gagcacgctc cagcccgcgg tctgggaccg
     9841 gctgctgcgg ctcccgacga agttcttcac ccagcgctcc accggagagc tcgcgagcgc
     9901 cgcgatgggg gtgagctcca tccggcgggt gctgtccggc acaggtcccg tcatcgtgca
     9961 ggcgggcacg ctcggggtga tgaatctggg tctgctgctc tggttcagcg tcccgctggc
    10021 gctcacggcc gtcgcgatgc tggtggtcat cgccgcggtg ttcctcacca tgggcatgtg
    10081 ggagctccgc tggcagcgcc ggctggtcga gctcgggaac aagctgaaca accaggcctt
    10141 ccagacgctg cgcgggctgc ccaagctgcg ggtcgcggcg gcggagagct tcgcgtacgg
    10201 ggcgtgggcg gcggagttcg cccgcagt
//
