LOCUS       NZ_CAKMXI010000015     11380 bp    DNA     linear   CON 03-JUN-2024
DEFINITION  Streptomyces atroolivaceus strain TUE2108, whole genome shotgun
            sequence.
ACCESSION   NZ_CAKMXI010000015
VERSION     NZ_CAKMXI010000015.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces atroolivaceus
  ORGANISM  Streptomyces atroolivaceus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 209944)
  AUTHORS   Wibberg,D.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-FEB-2022) CEBITEC, Genome Research of Industrial
            Microorganisms (GRIM), Universitaetsstrasse 27, 33615, NRW, Germany
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_928722305.1-RS_2024_06_03
            Annotation Date                   :: 06/03/2024 04:23:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,057
            CDSs (total)                      :: 6,983
            Genes (coding)                    :: 6,683
            CDSs (with protein)               :: 6,683
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 2 (5S, 16S)
            complete rRNAs                    :: 1, 1 (5S, 16S)
            partial rRNAs                     :: 1 (16S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 300
            CDSs (without protein)            :: 300
            Pseudo Genes (ambiguous residues) :: 0 of 300
            Pseudo Genes (frameshifted)       :: 123 of 300
            Pseudo Genes (incomplete)         :: 254 of 300
            Pseudo Genes (internal stop)      :: 20 of 300
            Pseudo Genes (multiple problems)  :: 87 of 300
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:59:12
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 42061
            Orig. end                         :: 53441
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CAKMXI010000015.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11380
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11380
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11380
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6380](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6380)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(160..174)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.47"
                     /tool="antismash"
     gene            complement(361..2118)
                     /locus_tag="NBY68_RS29785"
     CDS             complement(361..2118)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010048312.1"
                     /locus_tag="NBY68_RS29785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_250293562.1"
                     /transl_table=11
                     /translation="MSNAMDTPTAGTFVPERGSLRALLPALAGHRAMTVRTCAAALLEQ
                     GSLVALLTLAAHTVGTAVIEGRAPSSGIVGVIVALVLVRTLMTWREMDLSHDLAYRVLA
                     VLRVRVFDGLARSAPARVAGRRSGDLAATAMADVEALEFFYAHTTAQLLASGTVFTAGT
                     AVLATVEPWLLAAVLPIAALLTAAPFAEARGRARRGARTRQAGAELSADAVETVDGLRE
                     LLAFGALDDRRSRLAERGRRVGDAQRVEATWEALAAAVRDLLIVVAVLGVVAAVAQSVT
                     SGRLHGAWAPAAMALALAVLGPVAESARSLSQAVSLRAAASRVGAAVKAPALAPPPVSP
                     RSLPQGPLGVRLHGVRFDYGGGPVLDGVDLTVPAGQTLALVGASGAGKSTCAHILARFW
                     DPAAGAVQLIPADGAPIDVREVDDTELRRSVALVGQETPLFHGTLADNLRLTAPEADDD
                     LLAETARLCGVDRIAPMDTLVGERGATLSGGQRARIALARALLTQPRVLILDESTAHLD
                     NASDAELATALHQEGRTTVVIAHRRATIRRCDRIAVLDAGRVTEEGTWEELTGRPDSAL
                     NRSLVHIPA"
     gene            complement(2115..3854)
                     /locus_tag="NBY68_RS29790"
     CDS             complement(2115..3854)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004004120.1"
                     /locus_tag="NBY68_RS29790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_250293563.1"
                     /transl_table=11
                     /translation="MIVHPELRRAARRVRRPLLAASLLQGAVTLTHLAQAVLLAFALAG
                     LARSHTGQLPWLLTTVVFVVAARAGLGTWQRRTATRAGAEARVALRDELLAHLGRLGPA
                     HLTTARAGAVRTTLVDGVEGVDAYVSRYLPQLLITLTVPPLVLAVLAVVEPMALIGLVP
                     ALLLALFGPRAWDRLLATRGKEHWDTYEGLGADYLEALQGMPALRAAGAVGRTRARLEK
                     RSAALHRATVAKLRVSLVDTGITDLAIQGGTAAAALLACWSAVSGSTTATGTYLVLLLA
                     SECFRPVRDLAREWHAGYLGASAADGIAALRTAEPEVRDTGTVSARWPTPPEVCFEDVR
                     FTYDGAPEPALHGVSFTAPAGRTTAIVGPSGAGKSTLLALLLRHHDPGEGRITLDGRSA
                     TQYSLEALRQGIAVVSQETYLFHATIADNLRMARPDATDDEVTSAARTAGIHDEITALP
                     DGYATVLGERGATLSGGQRQRLALARALLTDARVLILDEATSSVDERREADIVRELMNA
                     ANDRTVLVIAHRLAAVQHADHIVVLEAGRVEAIGEHAGLADAGGVYARLVEAGRTHPEE
                     LAA"
     gene            complement(3851..4822)
                     /locus_tag="NBY68_RS29795"
     CDS             complement(3851..4822)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004004119.1"
                     /locus_tag="NBY68_RS29795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SagB/ThcOx family dehydrogenase"
                     /protein_id="WP_250293564.1"
                     /transl_table=11
                     /translation="MLRLSLRASDDSGRLRPAPSAGALHPVDTELVLGTGCPLPPGRYG
                     YDPLRDHVHRLGGQPDTEPPGIRVELSVTARRTISHYGHRAWPLLLLDTGHATAALFLA
                     AHALGMAVPELSLDGDAETPLAFVRIAPSLPAPGPGDPMCPPPSVRVPTPEELLARRSA
                     PPPLPGTPTPDALRAVLASATKAGGGDLRWCVAVGPPRPGLMELGAGGTTLRRFAAGEA
                     RPTLAAWAAGQAWIADAGAVLLARGCPQDADERHIRRTHLRAGFAVQLAHVTARHHGVA
                     ARPVGSWQQADLGAALGDTPGRDWIVHGLALGTLHADEENTT"
     gene            complement(5001..6380)
                     /locus_tag="NBY68_RS29800"
     CDS             complement(5001..6380)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008409979.1"
                     /locus_tag="NBY68_RS29800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YcaO-like family protein"
                     /protein_id="WP_250293565.1"
                     /sec_met_domain="YcaO (E-value: 2.9e-50, bitscore: 165.4,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTALPLEALVDPVCGIVRKVKPVEHPAGAPPRYTALTAEIADARK
                     LGLWPADRVSLGTTFGDPEQARIAAIAEGIERYCGNRVPPPGHPDAPRRATAAELAQQG
                     LRLYGPDDLPVYAPWQYTRVTFPYRRLAEDTPSLWTRGTERLPDGRTTEVWAPVALTHL
                     NWRQGDLRELPRTHHLNYAGIATGQGFDDAVERGLLEIVERDALELWWHLDGPTRGIDP
                     ASVPGLMDDLAGSALDVHLVEMPSEFAPCVAALVHDPALGLYAAGFACKYDPAEAARKA
                     VLEAVHTWVFTQGLTDPDGWVFQAVEAGLLARGLYLEHRADGRYLDACGEHFEHVRDLG
                     AHVQVWLDERMTTEARRFTEPAHRTVSVDAIEPGSRERLEKALHAGGHRVMTFDLTTED
                     VAETSLRVARVLVSGLLPNAPAAFGYFGCPRLAEAAVRRGWRTNAPGTPDDFTLAPPPH
                     M"
     gene            complement(6377..7858)
                     /locus_tag="NBY68_RS29805"
     CDS             complement(6377..7858)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010048304.1"
                     /locus_tag="NBY68_RS29805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CocE/NonD family hydrolase"
                     /protein_id="WP_250293566.1"
                     /transl_table=11
                     /translation="MTVFRPTVDGLATDVCLPDGAGPFPAVLIRTPYDRARHLAEARGW
                     ARRGFGAVVQDVRGRFASPGEWRPYENEAADGVAAARWIRRQPWSDGRYVAVGASYAAY
                     CALSLALEAHREDQPNAVIAAVPALGATETAREPSGAERLLTRAGWWAAHGDRRDSDER
                     ALERALAADPGLLGHLPLTDLPGRLGRNLPSWAGLWRRDDRGRLTSRATHADMPLLMVG
                     GHHDHFTEDTVALWRTWGGPSARLLLGPWGHGLVTAPGPDAGPAHRVSLGELYVRWARR
                     ALADGLAPGHHGAVALGDGDLWMPAGTDGHPTTQRLRLLHGSVFTADPDRPVRSDDLTV
                     PTGDFPDRCVLVTSPLPRPLDAVGPVRVHLRAIADTPSADWAARLVALTPEGTAEPLVV
                     GILRREDKAGHSSELTIELGHLARRLAVGTRLRLEIAGHHFPAHARNPHTGGDPITSDR
                     LLASRREVDPASVTLNLHVLPFRPPSVDPTEEILR"
     gene            complement(7855..8712)
                     /locus_tag="NBY68_RS29810"
     CDS             complement(7855..8712)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010048303.1"
                     /locus_tag="NBY68_RS29810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_250293567.1"
                     /transl_table=11
                     /translation="MSRNQLAPGVEVVAVPGRNLAVRTADGEFLSVRTRDVHQDALLSL
                     LSGNNAVPKGAELGRVLRAFAEAGYLVEEPERPKWPVARRHVRLLGAAALTEPLAAHLA
                     SLGAEPRTTATAATAADLSPMDIEDLLEGDPAAVVWCLDGPVPDGLWDAADRLPEHGVA
                     WLRCHHEGWQAYVEPLAIGPGDVTAAHVRARRLAATPAHRELSAYWSGPRASGVPVRLT
                     VPAAALLAALLADDLGRWATGAPETAGFPARRRLRQVDLRTLTVTEHPVMPVPDVARMP
                     KKDR"
     gene            complement(8804..8917)
                     /gene="amiA"
                     /locus_tag="NBY68_RS29815"
     CDS             complement(8804..8917)
                     /codon_start=1
                     /gene="amiA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010048301.1"
                     /locus_tag="NBY68_RS29815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="streptamidine family RiPP"
                     /protein_id="WP_250293568.1"
                     /transl_table=11
                     /translation="MDNEQFFAPIADPGQLAHDSASHSNALVENPFEDTEE"
     gene            complement(8976..9797)
                     /locus_tag="NBY68_RS29820"
     CDS             complement(8976..9797)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010048299.1"
                     /locus_tag="NBY68_RS29820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_250293569.1"
                     /transl_table=11
                     /translation="MTKSMGIHIEDVHFGYPARPVLQGVDVTVRPGELTALIGLNGCGK
                     STLLRLAAGLLQPDQGRVLLGGDDLAGLSRRATAARVALLHQSAPAVPGMTVRHLVRQG
                     RYAARGPLGMLREGDDPVVRRALRDVGVEQWADRDVDALSGGERQRVRLAMALAQDTRV
                     LLLDEPTTYLDLHHQLDVMQTVVRLREERELTVVMVLHDLAHAARFAERIVALRDGRVV
                     ADGTPKEVVTPGLLADVLNVAGRVGRDPEGGWPVCYPDHPLPALEYENQFH"
     misc_feature    9775..9788
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.85"
                     /tool="antismash"
     gene            complement(9817..10824)
                     /locus_tag="NBY68_RS29825"
     CDS             complement(9817..10824)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006826 - iron ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1011: transport
                     system permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019328328.1"
                     /locus_tag="NBY68_RS29825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="iron ABC transporter permease"
                     /protein_id="WP_250293570.1"
                     /transl_table=11
                     /translation="MRWRFVALSALAVVCAGLELVAGRGMSPGAVWDVLGGGGDATERH
                     IFLQLRLPRMLVALGAGACLAMAGLILQSALRNPLAGPEVTGVTPGAVLGAVTATALGL
                     AGWESPLAVVLAACAGGCAGALLLWLLVGRGGGDPAQTAVHGVLVSAVLGGLTAMVLLV
                     EPGELGSVVQWLVGTTEGRVWEHWHLLWSWALVWGVAAWLLAGPLTLLRCGDDIAMSAG
                     LSVRRARTLALMCAVALTAGAVAAVGALGFVGLLVPHLAMAVFGADLRVGLPGAALLGA
                     VVVCGADAVAQLSSRLLAATLDSGRLTLPVGALTACLGAALLLVVVRRTPSRTF"
ORIGIN
        1 gcggacgacc gcggcaccgg ccaggccggc tcttcgccga ccgcggctac gactacgaca
       61 agtaccgccg catcctccga gcccgcgcga acatcacacc caggatcgcc cgccgaggcg
      121 tcccgcacgg atcgggactg ggcaagacct gctgggtcgt ggaacggacc ttcgcccggc
      181 tccaccagtt caaacgcctg cgcatccgcc acgagatacg cgccgacctc caccttggct
      241 tgctcccact cgcctgcagc atcatctgct tgcgacgccc acgacctcat tcggtaacga
      301 tcagatagaa gacccgcagg atgtgttctg ccccacctcg gccgtcgcac tacccgacag
      361 tcaggccgga atgtgaacga ggctgcggtt gagcgcgctg tcggggcggc cggtcagttc
      421 ctcccaagtg ccttcctcgg tgacgcgtcc ggcgtcaagg accgctatgc ggtcgcaccg
      481 gcggatggtg gcgcggcgat gggcgatgac aacggtcgtg cgcccctcct gatgcagcgc
      541 cgtggcgagt tcggcgtcac tggcgttgtc caggtgggcg gtggactcgt ccagtatcag
      601 gactctcggc tgtgtcagga gcgcgcgggc gagggcgatt cgggcccgct ggcctccgga
      661 gagggtggcg ccgcgttctc cgaccagggt gtccatcggg gcgattcggt cgacgccgca
      721 cagacgggcc gtttcggcga ggaggtcgtc gtcggcctcg ggagcggtga ggcgaaggtt
      781 gtcggcgagg gtgccgtgaa agagaggtgt ctcctgtccc acgagcgcga cggaccggcg
      841 aagttcggtg tcgtccacct cgcgtacatc gatgggggcc ccgtccgcag gtatcagctg
      901 taccgctccg gcggccgggt cccagaagcg cgccagaata tgggcacacg tcgacttccc
      961 ggcgcccgag gcgccgacca gggcaagtgt ctgcccggct ggaacggtca ggtcgacgcc
     1021 gtccagcacg ggaccgccgc cgtagtcgaa cctcaccccg tgcagccgga cgcccagggg
     1081 gccctgggga agagaacggg gtgagaccgg cggcggagcg agggctggag ccttgaccgc
     1141 agcacccacg cgggaggcgg cagcacgcag ggacacggcc tggctcaggg accgggccga
     1201 ctccgcgacg gggccgagga cggcgagggc gagggccatc gctgcaggtg cccacgcccc
     1261 gtgcagccgc cccgaggtca cggactgcgc cactgcggcc acgacaccga ggacggccac
     1321 cacgatgaga aggtcacgga ccgcggcggc cagggcctcc caggtggctt cgacgcgttg
     1381 ggcgtcgccc acccgccgtc cgcgttccgc cagtcggctt cgtcggtcgt cgagggcgcc
     1441 gaaggcgagc agttcacgca gtccgtcgac ggtttcgacg gcgtcggccg acagctcggc
     1501 gccggcctgc cgcgtgcggg caccacgcct cgcgcgcccg cgtgcttcgg cgaacggagc
     1561 tgcggtgagc agcgctgcga tcggcagcac ggcagccagc agccacggct ccaccgtggc
     1621 gaggaccgcc gtgccggcgg tgaagaccgt tcccgaagcg aggagctggg cggtggtgtg
     1681 ggcgtagaag aactccagtg cctccacgtc ggccatggcg gtggcggcga gatccccgct
     1741 gcgccggcct gcgacacggg cgggcgcact gcgggccaac ccgtcgaaga cgcgtacgcg
     1801 tagtacggcg aggaccctgt aggccaggtc gtgcgagagg tccatctcac gccaggtcat
     1861 cagggtgcgt acgaggacca gggccacgat cacgccgacg atgccggagg acggggctct
     1921 gccttcgatc acggccgtcc ccacggtgtg cgccgccagc gtcagcagcg cgacgagaga
     1981 gccctgttcg aggagagctg cggcacacgt gcggaccgtc atggcccggt gcccggcaag
     2041 ggcgggaagc agcgcgcgaa gcgaaccgcg ctcgggcacg aatgtgccgg cggttggggt
     2101 gtccatggcg ttgctcatgc ggcgagttcc tcagggtggg tgcggcctgc ctcgacgagt
     2161 cgcgcgtaga cgccgccggc gtcggcgagc ccggcgtgtt cgccgatggc ctcgacacgt
     2221 cctgcttcga ggacgacgat gtggtcggcg tgttggacgg cggccagccg gtgggcgatc
     2281 acgagaacgg tccggtcgtt tgcggcattc atcagttcgc ggacgatgtc cgcttcgcgg
     2341 cgctcgtcga ccgagctcgt cgcctcgtcg aggatgagca ccctggcgtc cgtgagcagg
     2401 gcacgggcga gtgcgagccg ctgtcgctgt ccgccggaga gggtggcgcc gcgttcgccg
     2461 aggacggtgg cgtagccgtc gggaagggct gtgatctcgt cgtggatgcc tgcggtacgc
     2521 gccgccgacg tcacctcgtc gtccgtggcg tccggccggg ccatgcgcag gttgtcggcg
     2581 atggtggcgt ggaagaggta cgtctcctgc gacacgacgg cgatgccctg ccggagtgct
     2641 tcgagggagt actgggtggc gctgcgcccg tcgagggtga tccggccttc gccagggtcg
     2701 tggtgacgca ggagcagggc gaggagcgtg gacttgcctg cgccggacgg gccgacgatc
     2761 gcggtggtgc gtcccgccgg tgcggtgaag gagacaccgt ggagggcggg ctccggtgcc
     2821 ccgtcgtagg tgaaccgcac gtcctcgaag catacttccg ggggtgtcgg ccagcgcgcg
     2881 gataccgttc cggtgtcccg gacctccggt tcggcggtgc gcagcgccgc gatcccgtcc
     2941 gcggccgagg cgcccaggta tccggcgtgc cattctcgag cgaggtcgcg gaccggccga
     3001 aagcactcgg aggccagcag cagcaccaga taggtgccgg ttgccgtggt ggacccgctg
     3061 acggccgacc agcacgcgag gagtgctgct gccgcggtac cgccctgaat ggcgaggtcg
     3121 gtgatgccgg tgtcgaccag ggagacgcgc agtttcgcga cggtcgccct gtgcagcgcc
     3181 gccgagcgct tctcaaggcg tgcgcgggtg cggccgaccg cacccgcggc ccgcagtgcg
     3241 ggcatgcctt gcaaggcttc cagataatcg gcgcccagtc cttcgtacgt gtcccagtgc
     3301 tccttgccgc gagtggccag gagccggtcc caggcgcgcg gcccgaacag ggccagcagc
     3361 agagccggta cgagaccgat caacgccatc ggttcaacca cggccagtac ggcgagcacc
     3421 aggggcggca cggtcagagt gatcagaagc tggggcaggt agcgcgagac ataggcatcg
     3481 acgccctcca cgccgtcgac gagggtggtg cggacggctc cggcgcgcgc ggtggtcaga
     3541 tgcgcgggcc ccagccgccc caggtgggcg aggagttcgt cccgcagcgc cactctcgcc
     3601 tccgctccgg cgcgggtggc ggtgcgccgc tgccaggtgc cgagtccggc ccgggcggcc
     3661 acgacgaaca ccacggtggt gagcagccac ggtagctgtc ccgtgtgact gcgggcgagt
     3721 ccggccaacg cgaaggccag cagcacggcc tgtgccaggt gggtgagggt aacggccccc
     3781 tgcaggagac tggcggcgag caggggccgc ctcacgcggc gggcggcacg gcgcagttcg
     3841 gggtggacga tcatgtggtg ttctcctcgt ctgcgtggag ggtgccgagg gccagtccgt
     3901 ggacgatcca gtcccggccg ggtgtgtcac caagcgcggc gccgaggtcc gcctgttgcc
     3961 aggagccgac ggggcgggca gccacaccgt ggtgtcgggc ggtgacgtgg gccagctgga
     4021 cagcgaagcc ggcccgcagg tgggtgcggc ggatgtgtcg ctcgtcggcg tcctgaggac
     4081 aaccgcgggc gagcaggacg gcacccgcgt cggcgatcca tgcctggccg gcggcccagg
     4141 ccgcgagcgt ggggcgggct tcccctgcgg cgaaccgtcg tagtgtcgtg ccgccggcgc
     4201 ccagctccat cagcccgggc cgaggggggc cgacggccac gcaccagcgc aggtctccgc
     4261 cgccggcctt ggtggcgctg gcgaggaccg ccctcagcgc atctggggtc ggcgtgccgg
     4321 gtagcggcgg cggtgcgctg cgtcgggcca gcagttcctc gggggtgggt accctcaccg
     4381 acggcggagg acacatgggg tccccgggcc cgggggctgg gagggaaggc gcgatccgca
     4441 cgaaggcgag cggtgtttcc gcgtctccgt ccaggctgag ttcgggcacg gccatgccca
     4501 gggcgtgggc cgcgaggaac agcgcggcgg tggcgtgccc ggtgtcgagg agcagcagcg
     4561 gccaagcgcg atggccgtag tgggaaatcg tccggcgtgc ggtgacggag agttcgaccc
     4621 tgatgcccgg cggctcggta tcgggttgcc cgccgagacg gtgcacgtgg tcgcgcagtg
     4681 ggtcgtagcc gtagcgcccg ggcggaagag ggcatcccgt gcccagaacg agttcggtgt
     4741 caaccgggtg cagtgcgccg gcggaggggg ccggccgcaa ccgaccggag tcgtccgagg
     4801 cacgcaggga aaggcgcagc atggcccgca ggtcgagatc cgcagggccc gcttccggga
     4861 tcgtgtgcag ccgtcccggc caagccggga cagccggtcc cgcaggtgtg tcggggcaag
     4921 ggcgtctcgg ggagcgggct tgggcgagag cagcggcgag gccctccggg ggggtctgat
     4981 cgaggtgttg cacgggttcc tcacatgtgg ggcgggggcg ccagcgtgaa gtcgtccggt
     5041 gtgcccggcg cgttcgtccg ccagccccgt cgcacagctg cttcggcgag ccgcgggcag
     5101 ccgaagtaac cgaaggccgc cggggcgttg gggaggagcc cggacacgag gacccgggcc
     5161 accctcagag acgtctcggc cacgtcctcg gtggtcaggt cgaaggtcat gacgcgatga
     5221 ccgcctgcgt gcagcgcctt ctccagccgc tcgcggctgc cgggctcgat cgcgtcgacg
     5281 gacacggtcc ggtgggcggg ttcggtgaac cgccgggcct cggtcgtcat ccgttcgtcc
     5341 agccatacct gcacgtgtgc ccccaggtcc cgcacgtgtt cgaagtgctc gccgcacgcg
     5401 tcgaggtagc ggccgtcggc gcggtgttcc aggtagagcc cacgggcgag caggccggcc
     5461 tcgacggcct ggaagaccca gccgtcgggg tcggtcagac cctgtgtgaa cacccatgta
     5521 tgaaccgctt ccagtaccgc tttgcgggcg gcctcggcgg ggtcgtactt gcaggcgaac
     5581 ccggctgcgt acaggccaag agccgggtcg tggacgagtg cggcgacgca aggggcgaac
     5641 tctgacggca tctcgacgag atggacgtcg agcgcggatc ctgccaggtc gtccatcaga
     5701 ccgggcacgc tggccgggtc gatgccgcgc gtcggcccgt cgaggtgcca ccacagttcc
     5761 agggcgtcgc gttcgacgat ctccaacagc ccgcgctcga ccgcgtcatc gaatccctgc
     5821 ccggtggcta tgcccgcgta gttgaggtga tgggtacggg gcagctcccg caggtcgccc
     5881 tggcgccagt tgaggtgggt gagggcgacc ggtgcccaga cctccgtggt ccgtccgtcc
     5941 ggcagccgct cggtgccgcg ggtccagagg gacggagtgt cctcggcgag gcggcggtag
     6001 gggaacgtca ccctcgtgta ctgccacggc gcgtacacgg gcaggtcatc agggccgtag
     6061 agccgcagac cctgctgagc cagctcggcg gcggtggcac gccggggggc gtcggggtgg
     6121 ccgggcggcg gcacgcggtt gccgcagtac cgctcgatcc cctcggctat ggcagcgatt
     6181 ctcgcttgct cggggtctcc gaaggtggtc ccgagggaga cccggtcagc gggccacaga
     6241 cccaacttcc gggcgtcggc tatctcggct gtgagtgccg tgtagcgggg aggggcaccc
     6301 gcggggtgtt cgacgggctt gaccttgcgg acgatgccgc agacggggtc gacaagagct
     6361 tccagcggca gcgccgtcat cgcaggatct cctcggtggg gtcgacggac gggggacgaa
     6421 acggtaggac gtgcaggttc agggtcacgc tcgccgggtc gacctctcgc cgggaggcca
     6481 acagacggtc cgaagtgatg gggtcgcccc cggtgtgggg gttgcgagcg tgagccggga
     6541 aatggtgtcc ggcgatttcg agtcgcagcc gcgtgccgac cgccagccga cgcgcgagat
     6601 gtccgagttc gatggtgagc tcgctgctgt ggcctgcctt gtcctcacgc cgcaggatgc
     6661 ctacgacgag gggctcggcc gtcccttccg gtgtgagggc gaccagacgg gcggcccagt
     6721 cggcggacgg ggtgtcggcg atggcccgca ggtggacgcg cacgggcccg acggcgtcga
     6781 gcgggcgcgg aagcggcgag gtgaccagca cacagcggtc ggggaagtcc ccggtgggca
     6841 cggtgagatc gtcggagcgg acgggacggt cggggtcggc ggtgaagacg gagccgtgga
     6901 gcagccgcag ccgctgcgtg gtcggatggc cgtcggtgcc ggcgggcatc cacaggtctc
     6961 cgtcacccag cgccaccgcg ccgtggtgcc cgggagcgag accgtcggcc agggcgcggc
     7021 gggcccaacg cacgtacagc tcaccgaggc tgacccggtg cgcgggacct gcgtcgggtc
     7081 cgggcgcggt gacgagaccg tgcccccacg ggcccaggag caggcgggcc gaaggcccgc
     7141 cccaggtgcg ccacagcgcg acggtgtcct cagtgaagtg gtcgtggtgg cctccgacca
     7201 tgagcagagg catgtcggca tgggtagctc gcgaggtgag acgaccgcga tcatcacgcc
     7261 gccacagccc cgcccaggaa ggcaggtttc ggcccagccg cccggggaga tcggtgagcg
     7321 gcaggtggcc gagcaggccg gggtccgctg ccagggccct ttccagcgcg cgttcgtcgg
     7381 agtcccgccg gtccccgtgg gcggcccacc acccggctcg ggtcagcagc cgttcggcgc
     7441 cggagggttc gcgggccgtc tctgtggcac ccagtgcggg cacggcggcg ataacagcat
     7501 tcggctggtc ctccctgtgt gcttcgaggg cgagggagag ggcgcagtag gcggcgtagg
     7561 aggctccgac ggcgacgtag cgtccgtcgc tccagggctg tcggcggatc caacgggctg
     7621 ccgccactcc gtcggcggcc tcgttctcgt acgggcgcca ctcccccggc gacgcgaatc
     7681 tgccccgcac gtcctggacg acggcgccga accctctgcg ggcccagcct cgcgcctcgg
     7741 ccaggtgtcg ggcacggtcg taaggagtac ggatgaggac ggcgggaaag ggaccggcac
     7801 cgtcgggcag acacacgtcg gtggcgaggc catcgacagt cggacggaag accgtcatct
     7861 gtccttcttc ggcatgcgtg cgacgtcggg caccggcatg acggggtgct cggtgacggt
     7921 cagcgtgcgc agatccacct gccgcagtcg acgccgtgcc gggaagccgg ccgtttcagg
     7981 ggcgccggtg gcccaccggc cgaggtcgtc ggcgagcagg gccgcgagca gtgcggcggc
     8041 gggcacggtc agccggaccg gcacaccgga ggctcggggt ccgctccagt aggcggacag
     8101 ctcgcggtgg gcaggggtgg cggcaagccg ccgggcacgg acatgggccg ccgtgacatc
     8161 tcctgggccg atggcgaggg gttccacgta cgcctgccag ccctcatggt ggcaccgcaa
     8221 ccaggccacc ccgtgctcgg gcagccggtc ggcggcgtcc cacagcccgt cgggtacggg
     8281 cccgtcgaga caccacacga cggcggcggg gtctccctca agcagatcct cgatatccat
     8341 gggcgacagg tcggcagcag tcgcggcagt ggccgtcgtc cgcggctcgg cacccaggga
     8401 ggcgaggtgc gcggccagcg gttcggtcag agccgcggcg ccgagtagcc gtacgtgccg
     8461 ccgagcaacg ggccacttcg ggcgctcggg ctcctccacg agatacccgg cctccgcgaa
     8521 agcgcgcagc acgcgtccca gttcggcacc tttcgggact gcgttgttgc cggagagcag
     8581 ggagagcagg gcgtcttggt gcacgtctcg cgtccggaca ctgaggaact ccccgtcagc
     8641 ggtgcgcacg gcgagattcc gccctggcac ggcgacaacc tcgacaccgg gtgcgagctg
     8701 attgcgggac acgatgttcc tcctgacgac tgagcacggg aaggggcgtg ggcccgcccg
     8761 gaaggcaacg ggcgggccca cggtcgaggg tggtcgacct cggttactcc tcggtgtcct
     8821 cgaaggggtt ctcgacgagc gcgttggagt gagaagccga gtcgtgggcc agctggcccg
     8881 ggtcggcgat cggcgcgaag aactgctcgt tgtccatgaa ctctccttgt ttatcgggga
     8941 gatacgccgt tcgggtgaac gtcgtaacgg agacactaat ggaactgatt ttcatattct
     9001 agagccggga gagggtgatc tgggtaacac accggccagc cgccctcggg gtcccggccg
     9061 acccggccgg ccacgttcag cacgtccgcc agcagtcccg gcgtgacgac ttccttcggc
     9121 gttccgtcgg ccaccacacg cccgtcgcgc agggcgacta tgcgctcggc gaaccgagcg
     9181 gcgtgggcca ggtcgtgcag caccatcacc acagtgagct cgcgttcctc ccgcagccgg
     9241 accaccgtct gcatcacatc cagctggtgg tgcaggtcca gataggtggt cggctcgtcg
     9301 agcagcagga cccgggtgtc ctgggcgagt gccatggcca gccgcacccg ctgccgctca
     9361 cccccggaca gggcgtccac atcacggtca gcccactgct ccacaccgac gtcacgcagc
     9421 gcccgacgca cgacgggatc gtccccctcg cgcagcatgc ccagcgggcc acgcgccgcg
     9481 taccgcccct gccgcacgag gtggcggacc gtcatacccg gtacggcagg cgcggactgg
     9541 tgcagcagcg ccaccctggc cgccgtggcc cgccgggaga gcccggcgag gtcgtccccg
     9601 ccgagcagaa cgcgcccctg gtccggttgc agcaacccgg cggccagccg caggagggtc
     9661 gatttgccgc agccgttcag gccgatgagg gctgtcagct cgcctggccg tacggttaca
     9721 tcgacgccct gcagcacggg tcgtgcgggg tagccgaagt ggacgtcctc aatgtggatg
     9781 cccatggact tggtcatgtt cggtcctccg tcgatgtcag aaggtgcggc tcggcgtacg
     9841 gcgtacgacg accagcagca gcgcggcgcc gaggcacgcg gtgagcgccc cgaccggaag
     9901 cgtgagccgc ccggagtcca gcgtcgcggc gagcagccgc gaggacagct gcgccacggc
     9961 atccgctccg cacaccacga ccgcgcccag cagggcggcg ccggggagac ccacccgcag
    10021 gtccgcaccg aagacggcca tggccagatg cgggacgagc agtcccacga agcccagcgc
    10081 tccgaccgcg gccacggccc ctgctgtcag cgctacagcg cacataaggg cgagggtccg
    10141 cgcccgccgg accgagaggc cggcggacat ggcgatgtcg tcaccgcagc gcagcagggt
    10201 cagcggcccg gccagcagcc acgccgcgac cccccagacc agggcccagg accacagaag
    10261 gtgccagtgc tcccacaccc ggccctccgt ggtccccacc aaccactgca caacgctccc
    10321 gagctccccc ggctccacaa gcagcaccat ggcggtgagc ccgccgagca ccgcggaaac
    10381 cagcactccg tgcacggcgg tctgggcggg atccccacct ccccggccga cgagcagcca
    10441 gagcagcagc gccccggcac atccgcccgc gcatgcggcg aggacaacgg ccaggggtga
    10501 ctcccaccct gcgagcccca aggccgtggc ggtgaccgca ccgaggactg cccccggcgt
    10561 cacgcctgtc acttccggcc cggccaaagg gttgcgcagc gcggactgca ggatcagccc
    10621 tgccatggcg aggcacgccc ccgcaccgag ggccaccagc attctgggaa gccgcagctg
    10681 gaggaagata tgacgttccg tcgcgtcgcc accaccgccc agcacgtccc agacggcgcc
    10741 gggggacatc ccgcgtccgg ccaccagttc cagcccggcg cacacgacgg ccaaagccga
    10801 cagtgctacg aaacgccacc tcaccgtggg tcctccgtac cagtcgtctc gccgggcagt
    10861 ggcacagtgc cgcgggcgcc gggctcctcc tggctaccgt tcccccgccc tccggcatga
    10921 ggtgcctcga cgtccggacg aggggtgtcg gtacgcggtc caggcaccag cgtgcgcacc
    10981 gcggccgcac cggttcgact gccctcggtc atccggtcgc ggcgacggga acgcatcagg
    11041 gcgatccccg cgggcactcc cagcagggcc gtccaggcac cggccggcgt ctccaccggc
    11101 gccagtgcca gccgcgccgg gacgtcggcg accgtcacga ccacggcacc ccacgcggcg
    11161 gaccatggaa gccaacgcac cgcacccgca gaggggtcga accatcgcgc caggtgcggg
    11221 gcgaggaacc ccacccatgc gacgggtccg catacggccg tcacgggtgc gatcagcacg
    11281 acggcgatgg ccagcgcggc cagccgcgcc cgctgggcac gcacacccag cgcctcggca
    11341 tcctcgtcgc ccaggcgcat gaccgagagc acaggcgcac
//
