LOCUS       NZ_CAKMXI010000012     10351 bp    DNA     linear   CON 03-JUN-2024
DEFINITION  Streptomyces atroolivaceus strain TUE2108, whole genome shotgun
            sequence.
ACCESSION   NZ_CAKMXI010000012
VERSION     NZ_CAKMXI010000012.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces atroolivaceus
  ORGANISM  Streptomyces atroolivaceus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 277362)
  AUTHORS   Wibberg,D.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-FEB-2022) CEBITEC, Genome Research of Industrial
            Microorganisms (GRIM), Universitaetsstrasse 27, 33615, NRW, Germany
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_928722305.1-RS_2024_06_03
            Annotation Date                   :: 06/03/2024 04:23:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,057
            CDSs (total)                      :: 6,983
            Genes (coding)                    :: 6,683
            CDSs (with protein)               :: 6,683
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 2 (5S, 16S)
            complete rRNAs                    :: 1, 1 (5S, 16S)
            partial rRNAs                     :: 1 (16S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 300
            CDSs (without protein)            :: 300
            Pseudo Genes (ambiguous residues) :: 0 of 300
            Pseudo Genes (frameshifted)       :: 123 of 300
            Pseudo Genes (incomplete)         :: 254 of 300
            Pseudo Genes (internal stop)      :: 20 of 300
            Pseudo Genes (multiple problems)  :: 87 of 300
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:59:12
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 149592
            Orig. end                         :: 159943
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CAKMXI010000012.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10351
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="2"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10351
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10351
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5351](-)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5351)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     gene            569..1384
                     /gene="griI"
                     /locus_tag="NBY68_RS26640"
     CDS             569..1384
                     /EC_number="4.1.2.56"
                     /codon_start=1
                     /gene="griI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012380462.1"
                     /locus_tag="NBY68_RS26640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="2-amino-4,
                     5-dihydroxy-6-oxo-7-(phosphonooxy)heptanoate synthase"
                     /protein_id="WP_033301960.1"
                     /transl_table=11
                     /translation="MVSHAFARSLRLQRLHHHDPGRLFIVPLDHSITDGPLTRGHHLDS
                     LVGELASHRVDGVVLHKGALRHVDPEWFTRTSLIVHLSASTVHAPDPNAKYLVSSVEES
                     LRMGADAVSVHVNLGSAEERHQIADMAAVAEACDRWNVPLMAMMYPRGPKIADPSDPAL
                     VAHAVQVAVDLGADLVKTLYVGSVDAMAEITSSSPVPVIVVGGPHDSDEARVLAYVEEA
                     LKGGAAGVAMGRNVFQAADPGAMADKISDLVHNGGKASSPVPAGSSRAA"
     gene            1443..2555
                     /gene="griH"
                     /locus_tag="NBY68_RS26645"
     CDS             1443..2555
                     /EC_number="4.1.99.20"
                     /codon_start=1
                     /gene="griH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018515803.1"
                     /locus_tag="NBY68_RS26645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="3-amino-4-hydroxybenzoic acid synthase"
                     /protein_id="WP_033301959.1"
                     /transl_table=11
                     /translation="MSSKLTWLDIRSLGDARAAIVQEALHHRVEAVVAGDPADLADLPP
                     TVSKVLLLEGGKLPESFGEATVVIVDPAKQGVTPAELALRHPEIEFGRFVEIIDAPTLE
                     DACESSRTEKWSVLLFRDPTKIPLEIVIAAAARATGSMITIAQDLEEAEILFGVLEHGS
                     DGVMMAPKKVGDAAELKRIAEAGIPNLNLTELRVVETSHIGMGERACVDTTTHFGEDEG
                     ILVGSHSKGMILCVSETHPLPYMPTRPFRVNAGAIHSYTLGKDERTNYLSELRTGSKLT
                     AVDIKGNTRLVTVGRVKIETRPLISIDAEAPDGRRVNLILQDDWHVRVLGPGGAVLNST
                     ELKPGDTVLGYLPTEDRHVGYPINEFCLEK"
     misc_feature    complement(1491..1507)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 21.78"
                     /tool="antismash"
     gene            complement(2530..3900)
                     /locus_tag="NBY68_RS26650"
     CDS             complement(2530..3900)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1169: sugar
                     transport protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012380460.1"
                     /locus_tag="NBY68_RS26650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aromatic acid/H+ symport family MFS transporter"
                     /protein_id="WP_250292956.1"
                     /transl_table=11
                     /translation="MYAVIALCWLVVFFDGFDVTVYGATMPYMLDDTSFGLDAAMAGSI
                     GSWTTFGMLVGALVAGNVTDWLGRRAVLVWCVVLFSAGSGVCALAGDPTQFAAGRCLAG
                     LGLGGLMPICLSVVAEFSPPRRMALATGVLMTAYHAGGMSATGVGLLLAPDHGWRWPFA
                     VGVLPALVAVPLLLRYLPESPGVLYGKGRVQEAREIARRYGLPAPTAENTPAAGVAGRL
                     RAVRSLMAPERRSATLLLWVASFCGLLLVYGISTWLPQLMRSAGYGMTTSVSLLMVINA
                     GGIIGMLVAGQVADRFGVVRVAASWFVLAAAGLALLATSPSLGATYAVVAFTGVWLFSA
                     STMVYAVAGRFYPAADRAAGLGWVTGVGRLGAVVSPWLGGVLVGHGLASQGFLVFALGG
                     LAGAVAVLLVPAVTSSWPRTPKTGPAAGGVRGDGAGAQERAEGVVPPLGPTSPGRTR"
     gene            complement(4049..4969)
                     /gene="griF"
                     /locus_tag="NBY68_RS26655"
     CDS             complement(4049..4969)
                     /EC_number="1.10.3.15"
                     /codon_start=1
                     /gene="griF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012380459.1"
                     /locus_tag="NBY68_RS26655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="grixazone synthase"
                     /protein_id="WP_033301957.1"
                     /transl_table=11
                     /translation="MVHVRKNHLDMTAEEKRRFVHAVREIKRRGIYDRFVDLHIRVNST
                     DYLDKETGKRLGHVNPGFLPWHRQYLLKFEQALQQVDRRVTLPYWDWTVDHGEDSPLWD
                     ENFMGGNGRPGDRRVMTGPFARDNGWKLNISVIPEGPEHPALNGHYTHDDRDYLVRDFG
                     TLTPNLPTPLELEQTLDLPVYDCPPWNHTSGGTPPYESFRNHLEGYTKFAWEAQVGKLH
                     GAAHVWTGGHMMYIGSPNDPVFFLNHCMIDRCWALWQERHPDVPHYLPVVPTQDVPDLN
                     TPLGPWHTKTPADLLDHTQFYTYDA"
     gene            complement(5001..5351)
                     /locus_tag="NBY68_RS26660"
     CDS             complement(5001..5351)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018515806.1"
                     /locus_tag="NBY68_RS26660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tyrosinase cofactor"
                     /protein_id="WP_250292958.1"
                     /sec_met_domain="melC (E-value: 6.9e-28, bitscore: 91.3,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATTGAALVAAAAAVPLMSGEDGGTAAAAPGDTAAGQYTERYLGR
                     TIRVAGEAAGGGVYIDDQPLHLMKFADDAYLSSMCHYAMAPTPLDAARRAVEELRGAAL
                     LPSAHGTHVTHL"
     misc_feature    complement(5368..5381)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.62"
                     /tool="antismash"
     gene            complement(5424..6794)
                     /locus_tag="NBY68_RS26665"
     CDS             complement(5424..6794)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018515807.1"
                     /locus_tag="NBY68_RS26665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_250292963.1"
                     /sec_met_domain="Aldedh (E-value: 7.3e-12, bitscore: 38.3,
                     seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTATRAPLSLDPRVCGRSVPSSDRTALPSVLGGDLADIGTAPRL
                     LALAALNEIRGHADGRAPDPAVFTEAARLFAVATLDGESPQDYVDRVCQATGLTSSAVG
                     QAVRDLVEEMEELPATTAAELPATGFGEGFDTRWVPRGKVFAAVMASNHPVPNISWVQA
                     LFHGYNVLVKPGSRDPFTPARLLAALVAAGLPPTKAAFLPCSREVGEFLLREADRGIIY
                     GGEKAVATWHQRESVAVRGPGRTKALLDVPADDAVMDHLALSASFDGGTRCTNLSAVLT
                     TGPVGEVADRLAERLGRLPSLPARDEGATLLVVNRARAAQLREQVAVLRAALTDHSARA
                     GEEETVVELEDGSFLLRPVVLSVDSAGHPALGTELPFPFVVVAPWSEADGVAPLRDSLV
                     LNLLTDREELVEAALREPSVRKVTRGRVLPWTAVPGIPHDDNYTQFLLEPKGLVAQG"
     gene            complement(6794..7852)
                     /locus_tag="NBY68_RS26670"
     CDS             complement(6794..7852)
                     /NRPS_PKS="Domain: AMP-binding (75-301). E-value: 3.6e-14.
                     Score: 44.0. Matches aSDomain:
                     nrpspksdomains_NBY68_RS26670_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012380456.1"
                     /locus_tag="NBY68_RS26670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AMP-binding protein"
                     /protein_id="WP_250292966.1"
                     /sec_met_domain="AMP-binding (E-value: 7e-11, bitscore:
                     35.1, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQMTDPGFDSHIRKLMGWHFGADTGSPFWLGKLSGLGFDPLTEV
                     QTLSDLTRFPDVSSELRSVPAQDLIPAGLADRPFRVYDSGGTTGSPKRVVDSAYRSLMT
                     VWGRERLLANGVPPHGNWLHLGPSGPHVIGFDTARYAALGGGIFYTVDLDPRWVKRLLS
                     QGRAADADEYVQHLLDQAETILESQDVTVLNTTPPLLEAICARPRLYELVRTRIRAIIW
                     AGTSISGESLRQLSEVFFPTASVVGVYGNSLMGVAPQRAARPGDTHPCVFEPFPDTTRL
                     QLVDDDGEPVAYGERGRVRLHLVAEEMFLPNILERDTAVRVEPVPGSPVDGLADVQTYR
                     SLDDVAIIEGVY"
     aSDomain        complement(6950..7627)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NBY68_RS26670_AMP-binding.1"
                     /evalue="3.60E-14"
                     /label="NBY68_RS26670_AMP-binding.1"
                     /locus_tag="NBY68_RS26670"
                     /protein_end="301"
                     /protein_start="75"
                     /score="44.0"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="DRPFRVYDSGGTTGSPKRVVDSAYRSLMTVWGRERLLANGVPPHG
                     NWLHLGPSGPHVIGFDTARYAALGGGIFYTVDLDPRWVKRLLSQGRAADADEYVQHLLD
                     QAETILESQDVTVLNTTPPLLEAICARPRLYELVRTRIRAIIWAGTSISGESLRQLSEV
                     FFPTASVVGVYGNSLMGVAPQRAARPGDTHPCVFEPFPDTTRLQLVDDDGEPVAYGERG
                     RVRL"
     gene            complement(8011..9363)
                     /locus_tag="NBY68_RS26675"
     CDS             complement(8011..9363)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018515809.1"
                     /locus_tag="NBY68_RS26675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_250292969.1"
                     /transl_table=11
                     /translation="MTTHEVASNAATTPLPSPGARSAGLRYGALFGPVVFGVTAAGVAL
                     PDVATALHASPTATAWVLTAHALALGVGTAVFGRLADTRGVRAALLFGSLVLAVGAVVC
                     LVAPNLGVLVAGRFVQAAGSGAMAACAMALTASVPPDRRPATLAGFGATMAVFSAGATL
                     AGGVLTEWVSWRIALVLPALSLLVVPLCLAAAPARKGSGRPMDLPGVTLLTLTAMSFLV
                     LIQSSALALGTPLVIGTAVVFLLAAAALVRRVRTSETSFVPRALVTDGVFVRAAIVGIG
                     VYGGLFAAMYAVPQLLVREHDWSVLSVGVWLLPGAVVGAVLSRLAGKLTAGDRGNRLLG
                     AVGVAFAAALGGALAGPDVVVLILGASLGFAAFSVTQVFTTALMSAHIEPARRAGAMGL
                     LNLTFFVGGGVGSATAGALAKSVSLSVSLGVIAAFPLVAALAAFTLTTRER"
     misc_feature    complement(9385..9398)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.35"
                     /tool="antismash"
     misc_feature    complement(9556..9569)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 20.06"
                     /tool="antismash"
ORIGIN
        1 cttgaggaca ggaccgcggt gatggccgtc gtccacgaca ccgaagtcgc ccggatcacc
       61 ctacgcaccc agaacgctcc ggacccgtcc ccggccgtgt tccagttcct ggcccaggag
      121 tccatccccg ccgacatgac cacggtctcc tcagctcccg gcggcggtta ctcgctcgga
      181 ctcaccgtgc accactcgca cgcggccgac atccgcaggt ccttctccga cctcacctcg
      241 acgggccggg ggcgggggga gatcgaggtc gaggaccagg tggcgaaggt ctcgatcgtc
      301 ggccacggcc tgctcagccg ccccgagtac gcgtccaggc tgctcgcctc gctcaccgga
      361 gcgggcatcg acgcccgctc actgaacgct tcgcagctcc gggtctcggt caccgtcccc
      421 agtgccgagg cggtccgcgc ggtggggctg ctccacagcg agttcgggct ggacgccgaa
      481 gccggcgcga tggccggcag cgtctccccc cgcccctgag gccaccaccc caagccgtga
      541 ccaccgtcga aacgcgacag gagcaccgat ggtttcccat gcattcgcca ggagcctgcg
      601 cctccaacgg ctccatcacc acgaccccgg gaggctgttc atcgttcctc tcgaccactc
      661 gatcaccgac ggccccctga cccgcggcca ccacctcgac tccctcgtgg gcgagctcgc
      721 ctcgcaccgc gtcgacggag tggtcctgca caagggagca ctgcgtcacg tcgacccgga
      781 gtggttcacc cggacctcac tgatcgtgca tctgagcgcc agcaccgtgc acgctccgga
      841 ccccaacgcc aagtacctgg tgtcgagcgt cgaggagagc ctgcggatgg gcgcggacgc
      901 ggtgagcgtg cacgtcaacc tcggctccgc cgaggaacgc caccagatcg cggacatggc
      961 ggcggtcgcg gaggcgtgtg accgctggaa cgtaccgctg atggccatga tgtacccccg
     1021 gggtcccaag atcgccgacc ccagtgaccc ggccctggtc gcccacgccg tgcaggtggc
     1081 cgtcgacctc ggcgccgacc tcgtcaagac gctgtacgtc ggctcggtgg acgcgatggc
     1141 ggagatcacg tcgtcctccc ccgttcccgt catcgtggtc ggcgggcctc acgacagcga
     1201 cgaggcccgt gtcctcgcct acgtcgagga ggcgctgaag ggcggcgccg ccggggtcgc
     1261 gatgggccgc aacgtcttcc aggccgctga ccccggggcc atggcggaca agatctccga
     1321 cctcgtccac aacggcggca aggcctcgtc gcccgtaccc gccggttcgt cccgtgccgc
     1381 ctgagtccgt ccggccgccc gtttccgcag tacccagtca ccacactcca aggagttctt
     1441 ccgtgtcttc gaaactgacc tggctcgaca tccgctcgct cggtgacgcc cgcgccgcca
     1501 tcgtgcagga ggccctccac caccgggtgg aggcggtcgt ggccggcgac ccggccgacc
     1561 tcgcggacct tccgcccacg gtctccaagg tcctgcttct cgagggcggg aagctcccgg
     1621 agtccttcgg cgaggccacg gtcgtcatcg tcgacccggc gaagcaggga gtgaccccgg
     1681 ccgagctggc actgcggcac ccggagatcg agttcggccg cttcgtggag atcatcgacg
     1741 ccccgacact cgaggacgcc tgcgagtcgt cgcgtaccga gaagtggtcc gtcctgctct
     1801 tccgcgaccc gaccaagatc ccgctggaga tcgtgatcgc ggccgccgcc cgcgccaccg
     1861 gatccatgat caccatcgcg caggacctcg aggaggccga aatcctcttc ggcgtactgg
     1921 aacacgggtc ggacggggtg atgatggccc cgaagaaggt cggggacgcc gcggagctca
     1981 agcggatcgc ggaggccggt atccccaacc tcaacctgac cgagctgcgc gtcgtcgaga
     2041 ccagccacat cggtatgggc gagcgggcct gcgtggacac caccacacac ttcggggagg
     2101 acgaggggat cctcgtcggt tctcactcca agggcatgat cctgtgcgtc agtgagaccc
     2161 acccgctgcc gtacatgccc acccggccgt tccgggtcaa cgccggtgcc atccactcct
     2221 acaccctcgg caaggacgag cggaccaact acctcagcga gctgaggacg ggcagcaagc
     2281 tcaccgccgt cgacatcaag ggcaacaccc gtctggtgac cgtcggacgg gtgaagatag
     2341 agacgcgtcc gctcatctcc atcgacgccg aggccccgga cggccggcgc gtcaacctga
     2401 tcctccagga cgactggcac gtccgggtgc tcggccccgg cggcgccgtg ctcaacagca
     2461 ccgagctgaa gccgggtgac acggtcctcg gctacctgcc caccgaggac cgccacgtcg
     2521 gctacccgat caacgagttc tgcctggaga agtaggcccg agcggcggta ccaccccctc
     2581 cgcccgctcc tgtgcaccgg ccccgtcgcc ccgtactccc ccggcggcgg ggccggtctt
     2641 cggcgtacgt ggccacgacg aggtgaccgc gggcaccagg agcaccgcga cggcgcctgc
     2701 caggccgccc agcgcgaaca ccaggaaccc ctggctcgcc aggccgtggc cgaccagtac
     2761 cccgcccagc cacgggctga cgacagcccc cagccggccg acgccggtga cccagccgag
     2821 accggcggcc cggtcggcgg ccgggtagaa gcggcccgcg accgcgtaga ccatcgtgct
     2881 ggcactgaag agccagacac cggtgaaggc gacgaccgcg tacgtggcgc ccagggaggg
     2941 cgaggtggcg agcagcgcca gtccggccgc cgccaggacg aaccaggagg ccgccacccg
     3001 gaccacaccg aaccggtcgg cgacctgccc cgcgaccagc atgccgatga tgcctcccgc
     3061 gttgatgacc atgagcaggc tgaccgatgt ggtcatgccg tagcccgcgg aacgcatcag
     3121 ctggggcagc caggtggaga tcccgtacac gagcagcagc ccgcagaagg acgccaccca
     3181 cagcagcagc gtcgcggacc tgcgctcagg ggccatcagg gaccgcaccg cgcgcaggcg
     3241 cccggcgact ccggcggccg gggtgttctc ggccgtcgga gccgggagac cgtaccgccg
     3301 cgcgatctca cgcgcctcct ggacacggcc cttgccgtag aggacaccag gggactccgg
     3361 caggtaccgc agcagcagcg gtacggcgac gagggccggg agcaccccga ccgcgaaggg
     3421 ccagcgccag ccgtggtcgg gggcgagcag cagccccacc cccgtggccg acataccgcc
     3481 cgcgtggtag gcggtcatga gcacgccggt ggcgagggcc atccggcgcg gcggggagaa
     3541 ctcggccacg acggagaggc agatcggcat cagcccgccc aggccgagac cggcgaggca
     3601 cctgcccgcc gcgaactgcg tggggtcgcc ggccagggcg cagactccgg accctgccga
     3661 gaacagcacg acgcaccaga cgaggacggc ccgtctgccg agccagtccg tgacgttgcc
     3721 cgcgacgagg gcaccgacga gcatgccgaa cgtcgtccag ctgccgatgc tgcccgccat
     3781 ggcggcgtcc agcccaaaac tcgtgtcgtc gagcatgtac ggcatggtgg cgccgtagac
     3841 cgtgacgtcg aagccgtcga agaagacgac gagccagcac agagcgatta ccgcgtacac
     3901 aggaatcctt ccgggtcggg gctgcgggtc ccccgacacg gcggcgccgg acaacgggaa
     3961 tccgctgtcc ggcgccgccg ggtgggagag aggacgttga ggtccgggcc gaccgggctc
     4021 accgccctgg tccggccgga cgggagccct acgcgtcgta ggtgtagaac tgcgtgtggt
     4081 ccaggaggtc ggccggggtc ttcgtgtgcc acggtccgag cggggtgttg aggtcgggga
     4141 cgtcctgggt gggcacgacc gggaggtagt gcggcacgtc ggggtggcgc tcctgccaca
     4201 gggcccagca gcggtcgatc atgcagtggt tgaggaagaa caccgggtcg ttgggcgagc
     4261 cgatgtacat catgtgcccg ccggtccaca cgtgcgccgc tccgtgcagc ttgcccacct
     4321 gcgcctccca ggcgaacttg gtgtagccct ccaggtggtt gcggaagctc tcgtagggcg
     4381 gggtgccgcc cgaggtgtgg ttccagggcg ggcagtcgta caccgggagg tcgagcgtct
     4441 gctccagctc cagcggcgtc ggcaggttcg gggtgagcgt gccgaagtcc cggaccaggt
     4501 agtcgcggtc gtcgtgggtg tagtgcccgt tgagcgccgg gtgctccggg ccctccggga
     4561 tcacgctgat gttcagcttc cagccgttgt cacgggcgaa ggggccggtc atcacccgtc
     4621 ggtcgccggg cctcccgttg ccgcccatga agttctcgtc ccacagcggg gagtcctcac
     4681 cgtggtcgac cgtccagtcc cagtacggga gggtgacccg gcggtcgacc tgctgcaggg
     4741 cctgttcgaa cttcagcagg tactgccggt gccagggcag gaagccggga ttgacgtgcc
     4801 cgagccgctt gccggtctcc ttgtcgaggt agtccgtgga gttgacccgt atgtggaggt
     4861 cgacgaatct gtcgtagatg ccgcgtctct tgatctcgcg caccgcgtgg acgaagcggc
     4921 gcttctcctc ggccgtcatg tcgaggtggt tcttgcgtac gtggaccatg gcagggcttt
     4981 ccttcgctcc ggggccggaa tcagaggtgg gtgacgtggg tgccgtgagc gctcggcagc
     5041 agtgcggcac cgcgcagttc ctcgacggct cgccgggcgg cgtccagcgg cgtgggcgcc
     5101 atcgcgtagt ggcacatcga gctgaggtag gcgtcgtcgg cgaacttcat gaggtgcaac
     5161 ggctggtcgt cgatgtagac gccaccgccc gcggcctcgc cggcgacccg tatggtgcga
     5221 ccgagatagc gctcggtgta ctgcccggcc gccgtgtcgc cgggcgcggc ggcggcagtc
     5281 ccgccgtcct ctccgctcat caggggtacg gcggccgctg cggcgacgag cgctgcacct
     5341 gtagtggcca tgaccatttc acgcctgttc atgggcatgc gggggcattc ctctcacgcg
     5401 ggtttcgacg gtggcgggcg gcttcagccc tgcgccacca ggcctttggg ttcgagcagg
     5461 aactgggtgt agttgtcgtc gtgcgggatg ccggggacgg cggtccaggg cagcacgcgg
     5521 ccgcgcgtca ccttgcggac gctcggctcc ctcagcgcgg cctccaccag ctcctcccgg
     5581 tcggtgagca ggttgaggac gagcgagtca cgcagcgggg ccactccgtc ggcttccgac
     5641 cacggagcca ccacgacgaa ggggaagggg agttccgtac ccagagccgg gtggccggca
     5701 ctgtccaccg acagcaccac ggggcgcagc agaaacgatc cgtcttccag ttccaccacg
     5761 gtctcctcct ctccggcccg cgcgctgtga tcggtcagcg cggcacggag gacggccacc
     5821 tgctcgcgca gctgagcggc acgggcccgg ttcaccacca ggagcgtggc cccctcgtcc
     5881 ctggcgggca gcgagggcag gcgacccagc cgttccgcga gccggtcggc gacctcgccg
     5941 accggcccgg tggtcaggac ggccgagaga ttggtgcacc gggtgccgcc gtcgaaggag
     6001 gcggacaggg ccaggtggtc catcacggcg tcgtccgcgg gcacgtccag cagcgccttg
     6061 gtgcgccccg gaccccgaac ggccaccgat tccctctggt gccaggtggc gacggccttc
     6121 tcgccgccgt agatgatccc gcggtcggcc tcgcgcagca ggaactcgcc cacctcccgc
     6181 gagcacggca ggaaggccgc cttcgtcggc ggcaggcccg cggccaccag ggcggccagc
     6241 agccgcgcgg gggtgaaggg gtcacggctg cccggcttga ccagcacgtt gtatccgtgg
     6301 aacagcgcct gcacccagga gatgttgggc acggggtggt tactggccat caccgcggcg
     6361 aagaccttcc cccggggcac ccagcgcgtg tcgaatccct cgccgaagcc ggtggcggga
     6421 agctcggccg cggtggtggc cgggagttcc tccatctcct cgaccaggtc cctgaccgcc
     6481 tggccgacgg ccgacgacgt caggccggtg gcctggcaga cccggtccac gtagtcctgc
     6541 gggctctcgc cgtcgagggt cgcgacggcg aacagccggg ccgcctcggt gaacaccgca
     6601 ggatcgggcg cccggccgtc cgcgtggccg cggatctcgt tgagcgccgc gagggcgagc
     6661 aggcgcgggg cggtcccgat gtcggcgagg tcgcccccga ggacgctggg cagggcggtg
     6721 cggtcggaac tgggtacgct ccggccgcag acgcgggggt cgagggagag gggcgcgcgc
     6781 gtggccgtgc tcatcagtag accccctcga tgatcgccac gtcgtcgagg ctgcggtagg
     6841 tctgcacgtc ggcgagtccg tcgacgggcg aacccgggac gggttcgacc cgtacggcgg
     6901 tgtcgcgttc caggatgttc ggcaggaaca tctcctcggc gaccaggtgc agccggaccc
     6961 gtccgcgctc gccgtaggcc accggttcgc cgtcgtcgtc caccagttgg agccgggtgg
     7021 tgtccgggaa gggttcgaag acgcaggggt gggtgtcacc ggggcgcgcc gcccgctgcg
     7081 gggcgacgcc catcaggctg ttgccgtaga cgccgaccac gctcgccgtc gggaagaaca
     7141 cctcgctgag ctggcgcagg ctctccccgc tgatggaggt cccggcccag atgatcgccc
     7201 ggatccgggt gcgcaccagc tcgtacagac gcggtcgggc gcagatggct tcgagcaggg
     7261 gcggggtggt gttcaggacg gtgacgtcct gcgactccag gatcgtctcc gcctggtcca
     7321 gcaggtgctg cacgtactcg tcggcgtccg cggcgcggcc ctgggacagc agccgcttca
     7381 cccagcgggg gtcgaggtcc acggtgtaga agatgccgcc gccgagcgcg gcgtaccggg
     7441 cggtgtcgaa cccgatgacg tgcgggccgc tcggcccgag gtggagccag ttgccgtgcg
     7501 gcggcacacc gttcgcgagg agccgctcgc gtccccacac ggtcatcagc gagcggtagg
     7561 cgctgtccac gacgcgtttg ggcgagccgg tcgtgccgcc cgagtcgtag acccggaacg
     7621 ggcggtccgc cagcccggcg gggatcaggt cctgggcggg gacggagcgc agttcggagc
     7681 tgacgtccgg aaagcgcgtc aggtcactca gggtctgcac ttcggtgagg gggtcgaaac
     7741 cgaggccgga cagcttcccg agccagaacg gggaaccggt gtcggccccg aagtgccacc
     7801 ccatcagctt gcgtatgtga ctgtcgaaac cgggatcggt catctgcgtc atggctgcct
     7861 tctgctctcc tggtcacggg gcaacggcgg tggggttcat ggtgcgggcg gtggctatcg
     7921 agctcgtatc gcccgcgttt cgtggtcccg gccgcacagg ccggagtgcc gggctccgtg
     7981 agcccggcac tcgtgggacg cacggtcgcg ctaccgctcg cgcgtggtca gtgtgaacgc
     8041 ggccaaggcc gcgaccagcg gaaaggccgc gatcacaccc agcgagacgg agagcgacac
     8101 ggacttcgcc agggcgccgg cggtcgcact gccgacccct ccgccgacga agaaggtgag
     8161 attgagcagg cccatggctc cggcccgccg cgccggttcg atgtgcgccg acatcagggc
     8221 ggtggtgaag acctgggtca ccgagaacgc ggcgaagccg agcgaggcgc cgaggatcag
     8281 cacgacgacg tcggggccgg ccagtgcccc gccgagggcc gccgcgaagg cgacgccgac
     8341 ggcgccaagg aggcggttgc cccggtcgcc cgccgtgagc ttgccggcca ggcgggagag
     8401 gaccgcgccg accacggcac cgggcagcag ccagacgccg acggacagga cgctccagtc
     8461 gtgttcgcgg acgaggagct gcggcacggc gtacatcgcg gcgaacagtc cgccgtagac
     8521 gccgattccg acgattgcgg cccggacgaa gacaccgtcg gtgacgagcg cgcgcgggac
     8581 gaaggaggtc tcgctggtgc ggacgcgccg gacgagggcc gccgccgcca ggaggaacac
     8641 gaccgcggtt ccgatcacca gcggggtgcc cagcgcgagc gccgacgact ggatgagtac
     8701 gaggaacgac atggcggtca gcgtcaggag cgtcacgccc ggcaggtcca tgggcctgcc
     8761 ggagcccttg cgggcggggg ctgccgccag gcagagcgga acgacgagca gggagagcgc
     8821 gggcaggacc agcgcgatcc gccagctcac ccactcggtg agaacgcctc ccgcgagggt
     8881 ggcgccggcc gagaagaccg ccatggtcgc accgaaaccg gccagggtcg cgggcctccg
     8941 gtccgggggc acggaggccg tgagggccat ggcgcaggcg gccatggccc ccgaccctgc
     9001 ggcctgcacg aaacggcccg ccaccaggac gccgaggttg ggcgcgacga gacagaccac
     9061 ggcgccgacg gccagcacca gcgatccgaa caggagggcg gcgcgcactc cgcgggtgtc
     9121 ggccaggcgc ccgaacacgg ccgttccgac accgagcgcg agcgcgtggg cggtcaggac
     9181 ccaggccgtg gcggtgggcg aggcgtgcag agcggtcgcc acgtcgggca gggcgacccc
     9241 ggcggcggtg actccgaaga cgaccgggcc gaagagcgca ccgtagcgca gtccggccga
     9301 gcgggcgccc ggggacggga ggggggtggt ggccgcgttc gacgcgacct cgtgagtggt
     9361 cacagaagct ccaaatttga tgggtgcatg ccaatacgat cgacccggtg cccgcacggc
     9421 gtggccggag cgcttccgcc gggaccgggc cggccggcgg accccgggcc gtcgtgatcc
     9481 gggatccgaa ggtcctacgg cacggggacg atgttgtggt tgagccggaa gatgttcccg
     9541 gggtcgtacg cggccttgat ccgggacagc ctcgtcaggg tctccgtgtc gaaacactcg
     9601 gccgtggcgt ccgccgtgtc ggaccccgcc aggaagttca ggtagcggcg gccggtgccc
     9661 cacggctcca tcgggccgag gaccgtgtcg gccgaccccg ggggcgacag cgtggagagg
     9721 gtgtacgcgc cctcccggac accgaccgcg ttgggtacgc cggccggccg gccgagcgcg
     9781 ccacccagct ggcgcagttc caccatcagg tcgccgcagt ccgaaccggg gccggccacc
     9841 cgcaggagcg tggccagcgc ctcggagtcc aactcccgca agacgatgtt gcgttcgtgg
     9901 tagggcagcg ggtgggtcgg gtcctgatgg atgtcggcga ccgccgtgta cggcatctcg
     9961 ccgaccgagt cctccatggc cgtcccgcac tcgcgcaacg gccggacgag ccgctcgccc
    10021 tcctcggcgg ggcccgtgta ggcgatccgc acgtgcgcgg cgacccttcc gcggaggaac
    10081 cggggcacat ccggcacgtc ggggagccgc aggagcgcga cggaggaggt catctcctcc
    10141 ggcacggtcg cggaccaccg gcgccaggtg tccaggacct ggacggcctg ctcaccgggg
    10201 aagtagagcc caccgccgta cagcctgcgc accggcatca gcgagaacca gatgccggtg
    10261 acgatgccga agttgccctt gcccccgcgc aacgcccaga agaggtccgg gtgctcgtcc
    10321 cgggagacca tccggacgtc tccgtcggcc g
//
