LOCUS       NZ_CAKMXI010000011     11293 bp    DNA     linear   CON 03-JUN-2024
DEFINITION  Streptomyces atroolivaceus strain TUE2108, whole genome shotgun
            sequence.
ACCESSION   NZ_CAKMXI010000011
VERSION     NZ_CAKMXI010000011.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces atroolivaceus
  ORGANISM  Streptomyces atroolivaceus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 307578)
  AUTHORS   Wibberg,D.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-FEB-2022) CEBITEC, Genome Research of Industrial
            Microorganisms (GRIM), Universitaetsstrasse 27, 33615, NRW, Germany
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_928722305.1-RS_2024_06_03
            Annotation Date                   :: 06/03/2024 04:23:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,057
            CDSs (total)                      :: 6,983
            Genes (coding)                    :: 6,683
            CDSs (with protein)               :: 6,683
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 2 (5S, 16S)
            complete rRNAs                    :: 1, 1 (5S, 16S)
            partial rRNAs                     :: 1 (16S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 300
            CDSs (without protein)            :: 300
            Pseudo Genes (ambiguous residues) :: 0 of 300
            Pseudo Genes (frameshifted)       :: 123 of 300
            Pseudo Genes (incomplete)         :: 254 of 300
            Pseudo Genes (internal stop)      :: 20 of 300
            Pseudo Genes (multiple problems)  :: 87 of 300
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:59:12
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1945
            Orig. end                         :: 13238
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CAKMXI010000011.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11293
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11293
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11293
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5000:6293](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6293)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            596..2083
                     /gene="hemG"
                     /locus_tag="NBY68_RS24730"
     CDS             596..2083
                     /EC_number="1.3.3.4"
                     /GO_function="GO:0004729 - oxygen-dependent
                     protoporphyrinogen oxidase activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015579252.1"
                     /locus_tag="NBY68_RS24730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="protoporphyrinogen oxidase"
                     /protein_id="WP_250292232.1"
                     /sec_met_domain="DAO (E-value: 6.3e-15, bitscore: 49.6,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQRPLQRDTTRTGHTVVIGGGIAGLAAAHRLLASGLRVTVLEATE
                     RLGGKLMTGEIAGTRVDLGAESMLARRPEAVDLARSAGLGDRLRPPATATASVWTRDAL
                     RPMPKGHVMGVPGDPAALGGLLSPEGLARIAEERDLTPTAVGDDVAVGSYVADRLGREV
                     VDRLVEPLLGGVYAGDAYRISMRAAVPQLFEAVKEGGPLLDGVLRIQERAAARQQTGPV
                     FQGIEGGIGTLPGAVAGTVRAGGGEILTETPVLGLTRTGEGWDVRTDSGVITADAIVLA
                     TPAWSASTLLAAECPAASVELAAVEYASMALVTMAFRRSDIENTEALRERSGFLVPPVD
                     GRTIKAATFSSNKWQWVADAAPDLFVLRTSVGRYGEEEHLHREDSELVAASLSDLASAT
                     GLAARPVDTEVTRWIGGLPQYPVGHLTRVARIRDEVAKLPGLRVCGAVYDGVGIPACVA
                     SAHRAADEIVQELTGPAAGEIDNTWTRVRGTGGEAGQ"
     gene            2088..2801
                     /gene="hemQ"
                     /locus_tag="NBY68_RS24735"
     CDS             2088..2801
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003965515.1"
                     /locus_tag="NBY68_RS24735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_250292234.1"
                     /transl_table=11
                     /translation="MSAPEKLPNAGKKAKDLNEVIRYTLWSVFRLKDLLPVDRAGYADE
                     VQELFDQLGAKDVTVRGTYDVSGLRADADLMIWWHAETSDELQEAYNLFRRTKLGRALE
                     PVWSNMALHRPAEFNKSHVPAFLADETPRDYISVYPFVRSYDWYLLPDEDRRRMLADHG
                     KMARGYPDVRANTVASFSLGDYEWVLAFEADELYRIVDLMRHLRASEARLHVREEVPFY
                     TGRRKSVAELVAGLA"
     gene            complement(3079..3855)
                     /locus_tag="NBY68_RS24740"
     CDS             complement(3079..3855)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153334.1"
                     /locus_tag="NBY68_RS24740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_250292235.1"
                     /transl_table=11
                     /translation="MLWVLLLLVAWCAAAVSCIRLCLLTASAALRPPGAAREPVSHELN
                     LYETAFLAGGPQRVADLALVSMHLRRRLLLAHTGWATVVDPEGRDEVERTVIRAIGPEG
                     QSRIAPIRAAAAAADAVRSLADRLVAAGLAVPHGARTSLDSAVRSVRGAAVLVVVLAAA
                     AVLMPGQETGYAGPVAAWFGLPLVLTLGCLAIARVENHPYSPWASPSGQHWLDSLPAPT
                     YGADRDLLAAVAVRGVGALEDPGLRAALLSGARTGG"
     gene            complement(3973..4995)
                     /locus_tag="NBY68_RS24745"
     CDS             complement(3973..4995)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153333.1"
                     /locus_tag="NBY68_RS24745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_250292237.1"
                     /transl_table=11
                     /translation="MNALALLLTLAVAVSSTLLVIATRRAGLRGSGTALYVHDLSEEAF
                     LNGGPARVVDAALTRMHSDGRLAVGGPGIVAVQRDNARDAVERAVLQELAVAPNGALHT
                     LRETVMRHPAVQEIGDGLAARGLLVAPGQSRTRRAWALTLGIGCIVGFPVSIALTIGQY
                     ALHDGYAGIPFPFFLKVLPALVIGAWAGLATAAAAKARLTMAGRRAADSYRLANAHVTD
                     PAHLVATQGLGALPDPELQGQLVAAARQRPSRRSPSASSSSYSPAAAAAFVPVLWCAGV
                     GPGGGCGGSTGGGGDSGTGSTCSSGSSCGSSGSSCGSSGGSSCGSGSSSGGGSSCGSSS
                     "
     gene            complement(5001..6293)
                     /locus_tag="NBY68_RS24750"
     CDS             complement(5001..6293)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153332.1"
                     /locus_tag="NBY68_RS24750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_250292238.1"
                     /sec_met_domain="DUF692 (E-value: 2.1e-93, bitscore: 306.5,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLGTGIGWRPEIADVIEALPGIDWVEAVAENLCTDHLPESLVRL
                     RERGVTVVPHGVSLGLGGADRPDPGRLAALAARAGLLGTPLVTEHIAFVRAGGPLTASP
                     LLEAGHLLPVPRTWDALDVLCENVRIAQDSLPVPLALENIAALISWPDEEMTEGQFLAE
                     LVERTGVRLLIDVANLHTNHVNRGEDPATALDELPVEAIAYVHVAGGVEKDGVWHDTHA
                     HPVTRPVLDVLGELRSRVDPPGVLLERDDDFPSAEELAGELSAIRATLSEASSGHRAVR
                     PRPARAPEPSSRAAGGRERTAVAQTALLSALVAGTPAPDGFDHRRLGVQSLALAAKRAA
                     VVAKVAPELPGFLGDGYREAFLSYARNRPMSAGYRRDALGFAEHLLVTGRPADDAARRK
                     LTRWWQERAAPRPPRRGARLVHAARAALLGR"
     gene            complement(6475..7227)
                     /locus_tag="NBY68_RS24755"
     CDS             complement(6475..7227)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153331.1"
                     /locus_tag="NBY68_RS24755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4142 domain-containing protein"
                     /protein_id="WP_250292665.1"
                     /transl_table=11
                     /translation="MRRINGTALIIAALVATLGALAFPVWSYADRSGTGEANLNASSVA
                     TQWGPLSATDRDFLIKVRLAGLWELPAGQQAIERAPSEGVKLAGDHLVVGHTDLDRRAR
                     DVAAKLGVELPNQPTEQQQGWLRELTAAGGQEYEQKFANLLRAAHGKVFALIAQVRHTT
                     RNALIRQLASDANQTVLDHITMLERTGFVDFDGLAREAAGASTASPSGPPMPPGGGVPP
                     APVPVTPSGDQSFTSRPVPPTMAPLPQP"
     gene            complement(7568..8332)
                     /locus_tag="NBY68_RS24760"
     CDS             complement(7568..8332)
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153330.1"
                     /locus_tag="NBY68_RS24760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptidyl-tRNA hydrolase"
                     /protein_id="WP_250292240.1"
                     /transl_table=11
                     /translation="MSSDSIPEPLPAAPDASAGSPFRTEPTARDEAPQFVLPLVVHLEK
                     TDPPARNDALVTAARAVLTILSDPRAQGEDEGRAEGEWAQAVREWQDARIRKVVRRARG
                     AEWRKASTLPGITVTGEHAEVRVFPPVPLDGWPKELAKLQVSGTDLDDPQAPAAPDPAG
                     PVLWMNPDVAMSAGKAMAQAGHGAQLAWWELSDAERKAWREAGFPLSVATPDTARWREL
                     TASGLPVVRDAGFTEVAPGSCTVVADHPALRR"
     gene            8407..9081
                     /locus_tag="NBY68_RS24765"
     CDS             8407..9081
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012378552.1"
                     /locus_tag="NBY68_RS24765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AIM24 family protein"
                     /protein_id="WP_250292242.1"
                     /transl_table=11
                     /translation="MKSDLFSSEHMAQQATAPGMTLQNAKSIKYAVNGEMHARQGSMIA
                     FRGNLQFDRKGQGIGGMLKRAVTGEGLALMAVSGQGEAWFAHEAANCFIVEMEQGDVLT
                     VNGRNVLCFDASLSYEIKTVKGAGMTGGGLFNSVFSGSGKLGLICEGQPIVIPVGAQQP
                     VYVDTDAVVGWSAQLSTSLHRSQSFGSMVRGGSGEAVQLMLQGEGFVIVRPSELKQEKS
                     SS"
     gene            9118..>9534
                     /locus_tag="NBY68_RS24770"
                     /pseudo=""
     CDS             9118..>9534
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="NBY68_RS24770"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGRRYGLRGPWVLRGLDLDLPLHTLVRVEGGNGAGKSTLLRLLAG
                     VDAPTEGRVTGRPRTAYVPERFPAALPFTAAGYLVHLGRVHGLPAAEAAAGAEEWLARF
                     GAAEHARTPLAELSKGTSQKVALAQALLAEPDLLV"
     misc_feature    complement(9157..9172)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.92"
                     /tool="antismash"
     gene            10099..10755
                     /locus_tag="NBY68_RS24775"
     CDS             10099..10755
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675662.1"
                     /locus_tag="NBY68_RS24775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter"
                     /protein_id="WP_250292668.1"
                     /transl_table=11
                     /translation="MRYQAALLARSQRWLAPLLLYVAALGIGVRAGQPLLDSLGYSAAV
                     LLPVTAWIVRLCVAQEPPAARAVTASAAGPSRAHRASLLTGLGCALALGAAGAGTVLLI
                     SDPVSTHHTVAVPLLPAAFAGLLAILCCALVGAAVGALCARPLLHRDGWSLVATVLGAL
                     LALVTDGSPAKAAVTGLVSGSLTGTARVPLLPSAAAVVVAVAVAAVTSRIAALRE"
ORIGIN
        1 gcgcaggacc tcgtcgtacc gggcctgggg cacgcgcagg acgaggtgcg acatgtcgtg
       61 ggtgtcgtcg acccgttccg tggtctcctc cgcgacgagt ccgccggcgt cctcggcggc
      121 gccgcgggcc gcggccaccg ccttcggcac gctcctcacc tcgatggaga gggtggccgt
      181 gcggatgaca tggaccgcga ccgcggagcc cggctccggg gccgtggagg cgccgtcggc
      241 gggcttcgcg gcggacttcc cggaggcgtc ggcaccggca ccggccgcgg cgggcgccgc
      301 cgccttgtcg tcggacgcgg atcgaagccc ctgccccccg ctgtcggagg ctccgcacgc
      361 tcctgtggcc aggagggcga cgagcagtcc ggcggccgcg agcgcgcgtg cgcggggccg
      421 gccggaccga gcgggtggat gactgtccgt gtggcgttcg tatggcatga cgcgtccccc
      481 cagggccgtt gtcgacagtg ctggttcgac gtacgggccc ggtacgcggg tttcccgcag
      541 gcggtttcga agtggtcacg ttcgggactc gggacgggtt tgagagagtg gacccatgca
      601 gcgtcctctt cagcgcgaca ccacacgcac gggccatacc gtcgtcatcg gcggtggcat
      661 cgccggactc gccgccgccc accggctgtt ggcctccggc ctccgggtca cggtcctgga
      721 ggcgaccgag cggctcggag gcaagctgat gaccggcgag atcgccggca cccgggtcga
      781 cctcggcgcc gagtcgatgc tcgcgcgccg gccggaagcg gtcgacctgg cccgctcggc
      841 cggactcggc gaccggctcc ggccgcctgc caccgccacc gcctcggtct ggacccgtga
      901 cgcactgcgc cccatgccca agggacacgt gatgggcgtc cctggcgacc ccgcggcgct
      961 cggcggcctt ctctcgcccg agggcctggc caggatcgcc gaggagcgcg acctcacccc
     1021 gaccgccgtc ggcgacgacg tcgccgtcgg ctcgtacgtc gccgaccggc tcggacgtga
     1081 ggtcgtcgac cggctcgtgg agccgctgct gggcggggtg tacgcgggtg acgcctaccg
     1141 gatctcgatg cgtgcggccg tgccgcagct cttcgaggcc gtgaaggagg gcggcccgct
     1201 cctcgacggc gtactccgca tccaggagag ggctgccgcc cggcagcaga ccggaccggt
     1261 cttccaaggc atcgaggggg gcatcggaac cctgccgggc gcggtggccg gcaccgtacg
     1321 ggccgggggc ggcgagatcc tcacggagac cccggtgctc ggcctgaccc ggaccggcga
     1381 gggctgggac gtgcgcaccg acagcggggt gatcaccgcc gacgccatcg tcctggccac
     1441 ccccgcctgg tccgcgtcca ccctgctcgc ggccgagtgt cccgcggcct cggtcgagct
     1501 cgccgccgtg gagtacgcgt cgatggccct ggtgaccatg gccttccggc gctccgacat
     1561 cgagaacacc gaggcgctcc gggagcgctc cggattcctc gtaccgcccg tcgacggccg
     1621 cacgatcaag gccgccacct tctccagcaa caagtggcag tgggtcgccg acgcggcccc
     1681 cgacctcttc gtgctgcgta cctcggtcgg ccgctacggc gaggaggaac acctccaccg
     1741 ggaggactcc gagctcgtcg cggcgtccct gagcgatctc gcgtccgcga ccggactggc
     1801 ggcccggccc gtggacaccg aggtcacccg gtggatcggc gggctgcccc agtacccggt
     1861 gggtcatctc acccgggtcg cccggatccg cgacgaggtc gccaagctgc ccgggctgcg
     1921 ggtgtgcgga gcggtctacg acggtgtcgg gatcccggcc tgcgtcgcga gcgcgcaccg
     1981 tgccgcggac gagatcgtcc aggaactcac ggggccggcc gcgggagaga tcgacaacac
     2041 gtggacccgg gttcggggca ccggtggcga ggcgggacaa tagccgtatg agtgcgccag
     2101 aaaagcttcc gaacgcaggc aagaaggcca aggacctcaa cgaggtcatc cgctacaccc
     2161 tgtggtccgt cttccggctg aaggacctcc ttcccgtgga ccgcgccggt tacgccgacg
     2221 aggtccagga gctgttcgac cagctcgggg ccaaggacgt cacggtccgc ggcacctacg
     2281 acgtgtccgg tctgcgggcc gacgccgatc tgatgatctg gtggcacgcc gagacctccg
     2341 acgagctcca ggaggcgtac aacctcttcc ggcgcacgaa gctgggccgc gcgctcgagc
     2401 cggtctggtc gaacatggcg ctgcaccgcc ccgccgagtt caacaagtcg cacgtgccgg
     2461 ccttcctggc cgacgagacc ccgcgcgact acatcagcgt gtaccccttc gtgcgcagct
     2521 acgactggta cctgctgccc gacgaggacc ggcgccgtat gctcgcggac cacgggaaga
     2581 tggcccgtgg ttaccccgac gtccgtgcca acacggtcgc ctccttctcg ctgggcgact
     2641 acgagtgggt cctcgccttc gaggccgacg agctctaccg catcgtcgac ctcatgcgtc
     2701 acctgagggc ctccgaggcg cggctgcacg tacgtgagga ggtcccgttc tacacggggc
     2761 gcaggaagtc cgtcgcagaa ttggtggccg gactcgcata gccagcgttt ccggtcatcc
     2821 cgacccggaa gatcagttgg cgggcaacgg cgtgtgagac gccgcccgcc gttccagcga
     2881 caccgggtcc ggtgccgggc gcacatcggc cgacggccgg cgaactgtcg tggcccacgg
     2941 gggagtcagc cattcctctc cgtgggcggc cgctcgccgg gtccggccga tgtgccccgg
     3001 gcctacaact ggatatgaca ccacgagggc cgctcccggc gacgggggcg gccctcgtgg
     3061 tgcacggccc cggacgggtc agcctccggt ccgcgccccg ctcagcaggg ccgcgcgcag
     3121 gccggggtcc tccagcgctc ccacacctcg taccgccacc gccgccagga ggtcgcggtc
     3181 cgcgccgtac gtgggtgcgg gcagcgagtc cagccagtgc tgcccggacg gggaggccca
     3241 cgggctgtac gggtggttct ccacccgcgc gatggccagg cagcccagcg tcagtacgag
     3301 cggcagcccg aaccaggcgg ccaccgggcc ggcgtacccc gtctcctgac cgggcatcag
     3361 cacggcggcg gccgccagga ccaccacgag caccgcggca ccccgcacgc tccgcaccgc
     3421 cgaatcgagg ctcgtccggg ccccgtgcgg tacggccagg cccgccgcga cgagccggtc
     3481 ggcgagggag cgtacggcgt cggctgcggc ggcagcggcg cgtatggggg ctatccggga
     3541 ctggccttcc gggccgatcg cgcggatgac cgtgcgctcg acctcgtccc gtccctccgg
     3601 gtcgacgacc gtggcccagc ccgtgtgggc gagcagcagc cggcgccgca ggtgcatgga
     3661 gaccagcgcc agatcggcca cccgctgcgg gccgccggcc aggaacgccg tctcgtacag
     3721 gttgagttca tgggagacgg gctcccgtgc ggcgccggga ggccgcaggg cggcactcgc
     3781 ggtgaggagg cacagccgga tgcaggagac ggcggccgcg caccatgcga cgagaaggag
     3841 gaggacccag agcatggcgg agttctatgc gaaaccggca gggaagcgcc atgggttgtt
     3901 cacgatttgg acgaatcccg gtcacaggcg gtcatcggtg gctgaatgtc gcgcatgaag
     3961 actccgcgcc cttcatgagc tgctgccgca actggaaccc ccgccactgc tcgacccact
     4021 gccgcagctg gaaccgccgc tgctgccgca actggacccg ctgctgccgc agctcgatcc
     4081 cgagctgcac gtggaacccg tccccgagtc gccgccccct ccggtggaac cgccgcagcc
     4141 gccgcccggc cccacccccg cgcaccacag caccggcacg aacgcggccg cggcggcggg
     4201 cgagtacgag gacgaggagg ccgacgggga acgccgcgag ggccgttgcc gggcggcggc
     4261 caccaactgc ccctggagct cggggtcggg gagtgccccc agcccctggg tggccaccag
     4321 gtgggccgga tcggtcacat gggcgttggc cagccggtag ctgtcggcgg ccctgcgccc
     4381 cgccatggtg agccgtgcct tggccgccgc cgcggtggcc agaccggccc aggccccgat
     4441 cacgagcgcg ggcagcacct taaggaagaa ggggaacgga atgcccgcgt acccgtcgtg
     4501 cagggcgtac tgcccgatgg tcagggcgat gctgaccggg aaccccacga tgcatccgat
     4561 gcccagggtg agtgcccagg cgcggcgggt ccggctctgg ccgggtgcga ccagcagccc
     4621 gcgggcggcc agaccgtcgc cgatctcctg caccgccgga tgccgcatga cggtctcccg
     4681 cagggtgtgc agggcgccgt tcggggccac ggccagctcc tggagcacgg cacgctccac
     4741 cgcgtcacgg gcattgtccc gctggaccgc gacgatgccg ggtccaccga cggccagccg
     4801 cccgtccgag tgcatgcggg tgagcgcggc gtccaccacc ctggccgggc cgccgttgag
     4861 gaacgcctcc tcggagaggt cgtgcacata cagggccgtg ccgctgcccc gcagaccggc
     4921 gcggcgcgtc gcgatgacca ggagcgtcga ggagacggcc acggcgagag tcagcagaag
     4981 agcaagagcg ttcatcacgg tcaccttccg aggagtgctg cacgggcggc gtggaccaga
     5041 cgggcccccc ggcgcggtgg acgaggggcg gcgcgctcct gccaccagcg cgtcagcttc
     5101 cggcgggccg cgtcatcggc cggccggcct gtgacgagga ggtgctcggc gaagccgagc
     5161 gcgtcgcggc ggtaaccggc ggacatcggc cgattcctgg cgtacgagag gaatgcctcg
     5221 cggtagccgt cgccgaggaa gccgggcagc tcgggcgcga ccttggcgac gacggcggcc
     5281 cgcttcgcgg ccagggccag gctctgcacc cccagccgcc ggtggtcgaa gccgtccggc
     5341 gcgggagtac cggccacgag cgcggagagc agagcggtct gcgccacggc ggtccgctcg
     5401 cggcccccgg cggcgcggga cgacggttcc ggggcccgcg cgggccgtgg ccgcacggcc
     5461 ctgtgccctg aggatgcctc gctcagcgtg gcccggatcg cgctcagttc accggccagc
     5521 tcctcggccg acgggaagtc gtcgtcgcgc tccagaagga cccccggcgg gtcgacgcgg
     5581 gagcggagct cgcccagcac gtccaggacg ggacgcgtca cggggtgggc gtgcgtgtcg
     5641 tgccagacgc cgtccttctc gacgccgccc gccacatgca cgtacgcgat ggcctccacc
     5701 ggcagctcgt ccagtgcggt cgcggggtcc tcgccgcggt tgacgtggtt ggtgtgcagg
     5761 ttggcgacgt cgatcagcag ccgtacgccg gtgcgctcga ccagctccgc caggaactgc
     5821 ccctcggtca tctcctcgtc gggccaggag atcaacgcgg cgatgttctc cagggcaagc
     5881 gggacgggca gcgagtcctg tgcgatgcgc acgttctcgc acagcacgtc cagcgcgtcc
     5941 caggtccgcg gcacgggcag cagatggccc gcttccagca gcggcgaggc ggtgagcggc
     6001 cctcccgcgc gcacgaaggc gatgtgctcc gtcaccaggg gtgtacccag cagtccggca
     6061 cgcgcggcca gagcggcgag acggccggga tcggggcggt cggccccgcc caggcccagc
     6121 gagaccccgt gcggcacgac cgtgaccccg cgctcccgga ggcgcacgag ggactcgggg
     6181 agatgatccg tgcagaggtt ctccgcgacc gcctcgaccc agtcgatccc cggcagcgcc
     6241 tcgatgacgt cagcgatctc cggccgccac ccgatgcccg ttcccagctt catggtgtcc
     6301 cctccccgtt ccgtgcaggg gtgatggccc agccgactgc cggcgaaccc ggaagcgggg
     6361 acgttcagag cttgatttga ggttcccgga cgggtcgccg ccgggtgacg tcgggcggag
     6421 gtgggaggcc ggtccctgac gcggcgcctg cacctccgga accgggggcc ggcctcaggg
     6481 ctgtggcagc ggagccatgg tcggtggcac cgggcgggag gtgaacgact ggtcgccgct
     6541 cggagtcacc ggcaccgggg ccggcgggac gccgcctccc ggcggcatgg gcgggcccga
     6601 cggactggct gtggaggcgc cggccgcctc gcgcgccagg ccgtcgaagt cgacgaatcc
     6661 ggtgcgctcc agcatcgtga tgtggtcgag caccgtctgg ttggcgtcgg aggcgagctg
     6721 ccggatcagc gcgttgcgcg tggtgtgccg gacctgtgcg atcagcgcga acaccttgcc
     6781 gtgcgcggcg cgcaggaggt tggcgaactt ctgctcgtac tcctggccac ccgcggcggt
     6841 gagctccctg agccagccct gctgctgctc cgtcggctgg ttcgggagtt ccaccccgag
     6901 cttggcggcc acgtcgcggg cccgccggtc caggtccgtg tggcccacca ccagatggtc
     6961 gccggcgagc ttcaccccct cgctcggcgc tcgctcgatg gcctgctgtc ccgcgggcag
     7021 ttcccacagc cccgcgaggc gcaccttgat caggaagtcc cggtcggtcg ccgagagcgg
     7081 gccccactgg gtggcgacgc tcgacgcgtt caggttggcc tcgccggtgc cggagcggtc
     7141 ggcgtaggac cacacgggaa aggcgagcgc gccgagcgtg gcgaccagcg cggcgatgat
     7201 gagggccgtt ccgttgatgc gtcgcagcaa gatgtctccc gggcaggtac gtgacagcgt
     7261 cgaatcaacc gccaactggc tcgtcgttca acctacttgg cggtaatgcc ggtgcggcag
     7321 taccgggaga tacgtatgtc ggcgcaggga tgttcagccg gtcgggctcc cgggtgactc
     7381 acagcttccc ctgggaggag cccagccctg ggccggtggg acagcggcta cgccccgccg
     7441 tgctccgccc ccgccgtgct ccgccccgga gctcgcccag gaggggtacg aggagtgcgc
     7501 cgcttgggtc gggcagcggg tcaggccgta cgagaggcgt gccgacggtg tcgggcagcg
     7561 ggtcaggtca gcggcgcagg gccgggtggt cggcgacgac ggtgcaggag ccgggggcca
     7621 cctcggtgaa gcccgcgtcc cgcaccaccg gcagcccact cgcggtgagt tcgcgccagc
     7681 gggcggtgtc cggggtggcg acggagagcg ggaaccccgc ctcgcgccac gccttgcgct
     7741 ccgcgtccga cagctcccac caggcgagct gggcgccgtg cccggcctga gccatggcct
     7801 tgcccgccga catggcgacg tccggattca tccacagcac gggaccggcc ggatcgggtg
     7861 ccgccggagc ctgggggtcg tccaggtccg tgcccgagac ctggagcttg gccagctcct
     7921 tgggccagcc gtccaggggc accggaggga acaccctgac ctccgcgtgc tcgcccgtga
     7981 ccgtgatccc gggcagcgtg gaggccttcc gccactccgc gccgcgcgcc cgccggacca
     8041 ccttgcggat acgggcgtcc tgccattcgc gcacggcctg cgcccactcg ccctcggccc
     8101 tgccctcgtc ctcgccctgg gcgcgggggt ccgagaggat cgtcagcacc gcacgggcgg
     8161 cggtcacgag ggcgtcgttg cgcgccgggg ggtcggtctt ctccaggtgc accaccagag
     8221 gcaggacgaa ctgcggggct tcgtcacggg ccgtcggctc cgtacggaac gggctgccgg
     8281 cggaggcatc cggtgctgcg ggaaggggct cgggaatgct gtcgctgctc acccgaccca
     8341 gtctgccagg cccctccggc aacctgttct tggcggaacg gtgggctccg ggtgaggatg
     8401 cacagcatga agagcgacct cttttccagc gagcacatgg cgcagcaggc gaccgccccg
     8461 gggatgaccc tgcagaacgc caaatccatc aagtacgccg tcaacggtga gatgcacgcg
     8521 cgtcagggat cgatgatcgc cttccgcggc aatctccagt tcgaccgcaa gggccagggc
     8581 atcggcggca tgctcaagcg cgcggtgacc ggcgaggggc tggccctgat ggcggtctcg
     8641 gggcagggcg aggcctggtt cgcccacgag gcggccaact gcttcatcgt cgagatggag
     8701 cagggcgacg tcctgaccgt caacggccgc aacgtgctct gcttcgacgc gagcctgtcc
     8761 tacgagatca agaccgtgaa gggcgccgga atgaccggcg gcggcctctt caacagcgtc
     8821 ttcagcgggt ccggcaaact cggcctgata tgcgagggcc agcccatagt gatccccgtc
     8881 ggcgcgcagc agccggtgta cgtcgacacg gacgcggtcg tcggctggag tgcccagctc
     8941 tccacgtcgc tgcaccgctc gcagagcttc ggctcgatgg tgcgcggcgg atccggcgag
     9001 gcggtccagc tgatgctcca gggcgagggg ttcgtgatcg tacgccccag tgagctcaag
     9061 caggagaagt cgtccagctg atcccgcgag gagtggaccg tcgtgatcct gcgaggagtg
     9121 ggccgccggt acggcctgcg tggaccctgg gtactgcgtg gtctcgacct cgacctgccc
     9181 ctgcacaccc tggtccgggt cgagggcggg aacggggcgg gcaagtcgac cctgctgagg
     9241 ctgctcgccg gtgtcgacgc gccgaccgag gggcgcgtca cgggccggcc ccgcacggcg
     9301 tacgtccccg agcggttccc agcggccctg ccgttcaccg ctgccggcta cctcgtccac
     9361 ctgggccgcg tccacggact cccggccgcc gaggccgccg caggggccga ggagtggctg
     9421 gcacggttcg gggccgcgga gcacgcccgt acgccccttg cggaactctc caagggcacc
     9481 agccagaagg tcgccctcgc ccaggcgctc ctcgccgagc cggatctcct cgtcctggac
     9541 gaggcatgga cgggcctgga ctccgcggcc cgcgctgaac tcgaccgggc ggtggcggag
     9601 caggtcgccc gtggtgccac cgtggtttac gtcgaccatg acccgcgacg gctcgccgga
     9661 tcggccgacg ccgtgtaccg gctggagggc cgtaccctcg tcgcggcgag ggacacccct
     9721 ccccgcgatc ccggcccacg cgtccggatc gaggcgacgg gccgggtgcc cgccgccctc
     9781 ccgccgggac tgcccggggc gccggaggtg gagtaccacg ccggaaaccc ggccgaggtc
     9841 cggttcacga ccaccgcggc ccactcggac cgtctgctcc acgccctcgt cacggcccgg
     9901 cctccgtggc acatcaccgg gctcgcacag gtcccggcac cggtccctgc ctccgtgacc
     9961 gccgcctctg accgggcggc cgttcagccg atgacggccc cggccccgga cccgggaacc
    10021 gctgccgttc cggccccgga caaggtgtcc ggaccggctc gcgcgacccg gccgccggtg
    10081 cgtgtcacgt tcgcgctgat gcgctatcag gccgcgctgc tggcacgctc acagcgctgg
    10141 ctcgcgcccc tcctcctgta cgtggccgcc ctcggcatcg gcgtacgggc ggggcagccc
    10201 ctgctggact cgctcggcta ctccgccgcc gtgctgctcc ccgtgacggc gtggatcgtg
    10261 cggctctgcg tcgcccagga gccgcccgcg gcccgagccg tgaccgcctc cgccgccgga
    10321 ccgtcgcgcg cccaccgcgc ctcgctgctc accggcctgg gatgcgcact cgccctgggc
    10381 gccgcggggg ccgggaccgt gctgctgatc agcgatccgg tcagcaccca ccacaccgtc
    10441 gccgtcccgc tcctgcccgc cgcattcgcc ggactgctcg cgattctgtg ctgtgccctg
    10501 gtgggagcgg cggtcggggc actctgtgcc cggccgctcc tgcaccgtga cggctggtcg
    10561 ctcgtcgcga ccgtgctcgg cgcgctgctc gccctcgtga ccgacggctc acccgcgaag
    10621 gccgcggtga cggggctggt ctccggctcg ctgaccggca cggcgcgggt tccgctcctg
    10681 ccttcggccg cggcggtcgt cgtcgcggtc gcggtggccg ccgtcacgtc ccggatcgcg
    10741 gctctgcgcg agtgagtacg ctcgtacgta tggacgatgc gtactgcgag acgcccccgc
    10801 cgacgccggc gcccgaggat gccgggccgt ccgtatgccg agtgcgtgct gtgccggaaa
    10861 ccgaccgaat acccggagtc gacgaagggc agcaccctct gcccggtctg cgcctggcag
    10921 gaggcgggac gcaccgcctg ttccggctga ggtgagagcg gggtgcggcc gaggcccctc
    10981 ggctcgttcg gaaggtccta gccgcgcatc agctcggaga ccttgacgaa gcggtagccg
    11041 cgctcgcgga gttccgggac gatccggcgc acggcgtcgt cggtgacggg ggccgcgctg
    11101 cgggtgcagt gcatgaccac cagcgacccc ggctccaccc ctgccagcac ctgctcggcg
    11161 accgcgtccg cgtccgtggc gaaggcgtcg ccgctgacca cgtcccactg gaccgcggtc
    11221 accccggtcg gggccagggc cttcagcgac tcgtcgtcgt agcagccgcc ggggaagcgg
    11281 aagtacggca cca
//
