LOCUS       NZ_CAKMXI010000007     10474 bp    DNA     linear   CON 03-JUN-2024
DEFINITION  Streptomyces atroolivaceus strain TUE2108, whole genome shotgun
            sequence.
ACCESSION   NZ_CAKMXI010000007
VERSION     NZ_CAKMXI010000007.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces atroolivaceus
  ORGANISM  Streptomyces atroolivaceus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 411765)
  AUTHORS   Wibberg,D.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-FEB-2022) CEBITEC, Genome Research of Industrial
            Microorganisms (GRIM), Universitaetsstrasse 27, 33615, NRW, Germany
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_928722305.1-RS_2024_06_03
            Annotation Date                   :: 06/03/2024 04:23:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,057
            CDSs (total)                      :: 6,983
            Genes (coding)                    :: 6,683
            CDSs (with protein)               :: 6,683
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 2 (5S, 16S)
            complete rRNAs                    :: 1, 1 (5S, 16S)
            partial rRNAs                     :: 1 (16S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 300
            CDSs (without protein)            :: 300
            Pseudo Genes (ambiguous residues) :: 0 of 300
            Pseudo Genes (frameshifted)       :: 123 of 300
            Pseudo Genes (incomplete)         :: 254 of 300
            Pseudo Genes (internal stop)      :: 20 of 300
            Pseudo Genes (multiple problems)  :: 87 of 300
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:59:12
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 199735
            Orig. end                         :: 210209
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CAKMXI010000007.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10474
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="4"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10474
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10474
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5474](+)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5474
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     gene            complement(89..1081)
                     /gene="dhaK"
                     /locus_tag="NBY68_RS19105"
     CDS             complement(89..1081)
                     /EC_number="2.7.1.121"
                     /GO_function="GO:0004371 - glycerone kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006071 - glycerol metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="dhaK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018514941.1"
                     /locus_tag="NBY68_RS19105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="dihydroxyacetone kinase subunit DhaK"
                     /protein_id="WP_033304835.1"
                     /transl_table=11
                     /translation="MRMLINVPETVVADGLRGMAAAHPELVVDTEKRLVVRRDAPVAGK
                     VGLVSGGGSGHEPLHAGFVGPGMLSAACPGEIFTSPVPDQMVRAAAAVDSGAGVLFVVK
                     NYTGDVLNFDMAAELAEDEGIQVARVLVDDDVAVADSTFTAGRRGTGATLFVEKIAGAL
                     ADEGAPLERVESLARRVNESSRSFGVALSSVTTPAKGTPTFDLPSGELELGIGIHGEPG
                     RERRPMMTSGEIADAAVHAVLEDLRPSGPVLVLVNGMGATPLLELYGFNAEVQRVLSER
                     GVSVARTLVGNYVTSLDMAGCSVTLCQVDEEMVRLWDAPVQTPALRWGR"
     misc_feature    complement(1064..1082)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.42"
                     /tool="antismash"
     gene            complement(1338..2090)
                     /locus_tag="NBY68_RS19110"
     CDS             complement(1338..2090)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019062555.1"
                     /locus_tag="NBY68_RS19110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_250290378.1"
                     /transl_table=11
                     /translation="MRVAVAGGTGAVGRLVVEELTAAGHDPVTLARSRGVDLVSGAGLD
                     AALVGVETVIDVSNRTTLGRDKAVSFFGSASRNLLDAGSRAGVRHHVALSVIGVDRVGH
                     GYYQGKLRQEEVVRGGQVPWTVLRAAQFHEFVPQTLDQMPKPLAVVPRMRTQPVAAREV
                     ARHLVDLALAPAQGMAPELAGPREEQLVDLVRRLLRARGERRPVVPVRLPGAAGAAMAG
                     NGQLPAGPGPRGTETFDEWLARTVARRG"
     misc_feature    complement(2041..2056)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.54"
                     /tool="antismash"
     gene            complement(2217..3410)
                     /locus_tag="NBY68_RS19115"
     CDS             complement(2217..3410)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015575909.1"
                     /locus_tag="NBY68_RS19115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyl hydrolase"
                     /protein_id="WP_250290380.1"
                     /transl_table=11
                     /translation="MPVQRRFINFGIGATALCLLVGGAVLADHDATDTQAGKGATQRAP
                     EPDRTTAIGAYLDYGPQGVQRMAELSRWLGGTELRVGHSYLPGDLWENIEGRPGFLAAW
                     AAWRKADEDRMFVLNTPMLERNEERVSDDEVRGLLRAGAYGQFDEHFRRLAERLVLLGV
                     PDTVIVLGWEMNGTTYTHRCGPDPVAWKAYWNRIVTAMRSVPGQDFRFDFAPSRGRDAV
                     PWTECYPGDDVVDIIGMDSYDQPPARTFDEQVNEPYGLQKQVDFAAEHGKPISFPEWGL
                     FRNGDNPEYMRRMLEWIERHKPVYQTITDYCPHGVWQCADNPHSSQVFREMLSGLPDAT
                     TPSPDADPSGTPTAPKPDKPTPTVPAPDANDPGWCVTLPLSDWFGRWLGDRELCVRD"
     gene            complement(3520..4809)
                     /locus_tag="NBY68_RS19120"
     CDS             complement(3520..4809)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014044247.1"
                     /locus_tag="NBY68_RS19120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_250290382.1"
                     /sec_met_domain="p450 (E-value: 8.6e-18, bitscore: 58.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEAPTPVTADRVRGAAGADLADPAFWRLPRSERLAAFARLRELDA
                     PVRFTPRTGPRTPFRALVKHADVKAASRQPQVFTSAPGVTVPEPAPWAKAVFGNSMVNM
                     DGAEHAGLRRTISRAFTPRLLAEAEENIGAVARRLVDEVVKEGPGDFMRSAPSRMPFEV
                     ICDLMGIPARHRPGIAARIDHASEYVGVRRRGRARLRIPGRGLRSLARMQLEMAGIARE
                     RRRVPADDVISALVRADVGGQALSSRQLGAFFSLLLVAGVETTRNAIAHGMVLLTAHPD
                     QRALLESDFDRYADGAVDEIVRHSTPIIQFRRTVASECALGGHTFLPGEKVVLLYASAN
                     RDASVFDDPDAFDITRSPNPHLGYGGGGPHHCLGAHLAKLEMKALFREMLTRLDGVRAS
                     GDPGLIDSNFDNRVRALPFTFDVRHPNGPL"
     misc_feature    4918..4933
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.83"
                     /tool="antismash"
     misc_feature    complement(4918..4936)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.97"
                     /tool="antismash"
     gene            5001..5474
                     /locus_tag="NBY68_RS19125"
     CDS             5001..5474
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014157950.1"
                     /locus_tag="NBY68_RS19125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tyrosinase cofactor"
                     /protein_id="WP_250290384.1"
                     /sec_met_domain="melC (E-value: 6.6e-48, bitscore: 157.0,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPTEGTCGEPAGAPRAARRAVLRTVFTAAVVAGTGGALAPVLLG
                     SPDPGGRTQERDAVGPERFSELYKGREIRGTATPVVPAGAQSHAGEAGAVAMTPGIDVS
                     VDGRALHVMRRADGSYISTVNHYESFPTLVETARAAVDELGTAQLSAVSPHII"
     gene            5495..6355
                     /locus_tag="NBY68_RS19130"
     CDS             5495..6355
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014157951.1"
                     /locus_tag="NBY68_RS19130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tyrosinase family protein"
                     /protein_id="WP_250290386.1"
                     /transl_table=11
                     /translation="MYSRKNQRDLTRTEKKRLVDAILELKRSGRYDDFVTLHRQYYVTD
                     TERRPRPAHMTPSFFPWHRRYLLEFEKALRAVDPRVTLPYWDWTRDDTASASLWAEDFL
                     GGNGRPGDRQVMTGPFAYRRGNWRIRAGVTDDPFLRRDFGRPSAPVTLPGAADVDRALK
                     DPVYDAEPWNSVSTTGFRNRIEGWGIRGARGVANHNRVHRWIGGSMAGAASPDDPVFWL
                     HHAFIDLLWTRWQKAHPRSPYLPARALPADDPQRDRIFASDQPMPPWDVAPSQLMDHTR
                     FYRYV"
     gene            complement(6462..6743)
                     /locus_tag="NBY68_RS19135"
     CDS             complement(6462..6743)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015575906.1"
                     /locus_tag="NBY68_RS19135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="chaplin"
                     /protein_id="WP_250290387.1"
                     /transl_table=11
                     /translation="MSRISKVAAVMAGTGALIAGGAGMAVADAGAEAVAAHSPGVLSGN
                     VVQVPVHIPVNVCGNTVNVIALLNPAFGNTCANVSDSHENKGEHGYGH"
     misc_feature    complement(6835..6844)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.29"
                     /tool="antismash"
     gene            complement(6855..8021)
                     /locus_tag="NBY68_RS19140"
     CDS             complement(6855..8021)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014157953.1"
                     /locus_tag="NBY68_RS19140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_250290389.1"
                     /transl_table=11
                     /translation="MNTGLRGRLTVTLCRDLPDFADLAPEWDALHRRCTSATPFQSHAW
                     LHSWWLSYGTPGRLRVLLARRGGRLIGAAPLMLVHRPMPLLVPMGGAISDFFDILADGE
                     DTRAAVDALGHGLHRAAAHAVVDLREVRPEASAHLLFEGWSGARSSRSDSTCMELPAEP
                     IDALIGRMTGSRAQRARAKLRRIDALGIECRTAPVHRVAGAVGTLLRLHELQWLGRGVN
                     PEHLRPRFCAHLVRSARRMVRDGEASVREFLLDGEVVAADLSFRSAQLTGGYLYGADPL
                     LRERKVDVSSMLLREIARETEGSDRGVLSLLRGSEQYKNHWGPVPVVNQRLLLARSALE
                     PLLRLREAQLTVRDRAAETVKSRLPGARDWRGRLSELPAAGLAVLGRS"
     gene            complement(8018..8686)
                     /locus_tag="NBY68_RS19145"
     CDS             complement(8018..8686)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012377858.1"
                     /locus_tag="NBY68_RS19145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lipopolysaccharide biosynthesis protein"
                     /protein_id="WP_250290392.1"
                     /transl_table=11
                     /translation="MTDSPEQQPSVIGRFRRLRPAFVRPAWWPLPACVLLGAACGFSYG
                     MLARPEYAATSYAMVTAGKDIDPAAALGYAQSYGRLATSDATLTYAKGAAGEPVRELRG
                     HVRSETSPDSPMIAVTGTSADRDRAADIANAVTEAVVVSSGHVAKDTGVKLIKFSHAVP
                     PVDPVSPSAPLGTAVGASVGGLVGGLVLLVRPRPGRRGVTAQVPAPAQGGASDERELAR
                     "
     gene            complement(8683..9834)
                     /locus_tag="NBY68_RS19150"
     CDS             complement(8683..9834)
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015575905.1"
                     /locus_tag="NBY68_RS19150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyltransferase"
                     /protein_id="WP_250290394.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 2.6e-20,
                     bitscore: 67.2, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKALHIITGLGVGGAEQQLRLLLRHLPVRCDVVTLTNPGAVAEGL
                     RADGVRVRDLGMRSNRDLGAVPRLARLIRRGSYDLVHTHLYRACVYGRIAARLAGATVV
                     ATEHSLGHAEIEGRPLTRGTRELYLRTERLGAATVAVSDTVAGRLRDWGVPAARIHTVP
                     NGIDAAAFRFDSAQRRSTRALLGLPDAAFVVGGVGRLVPGKRFDLLIGAVAALPGAWLV
                     LAGDGPEAVPLRALAARLGVAGRVRFLGECGTAGAAPTIPAVLSAVDIFVSASREESFG
                     LAVVEALAAGLPVVHAACPAVEDLPAGRVPGTTRIGSASGTTGPAEELTAALRHHVESG
                     TRRLPPPPVVDAYDIRSSSRRLMDVYAQAVATAPLPPTERVHP"
     misc_feature    10303..10318
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.03"
                     /tool="antismash"
     misc_feature    complement(10362..10380)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 21.57"
                     /tool="antismash"
ORIGIN
        1 cgacagccgc ggtggcagcc atccagcgac ggaagaaatc ggtgtcgagc acaagatctc
       61 ctgttcctca cacggtggga gggcccgttc accggcccca gcggagtgcg ggcgtctgta
      121 ccggtgcgtc ccagagccgc accatctcct cgtccacctg gcagagcgtc accgagcagc
      181 ctgccatgtc cagcgacgtc acgtagttgc ccaccagcgt acgagccacc gaaacgcccc
      241 gctccgacag cacccgctgc acctcggcat tgaacccgta cagctccagc agcggagtcg
      301 cgcccatccc gttgaccagc accagcacgg gaccgctggg ccgcagatcc tccagcaccg
      361 cgtggaccgc ggcgtcggcg atctcgccgg acgtcatcat cgggcggcgc tcccggccgg
      421 gctcgccgtg gatgccgatg cccagttcga gttcgcccga gggcagatcg aacgtgggag
      481 tgcccttcgc cggagtggtg acggagctga gcgccacccc gaagctccgc gaggactcgt
      541 tcacccgccg ggccagggac tccacccgct ccagcggcgc accctcgtcg gccagcgccc
      601 cggcgatctt ctcgacgaac agcgtcgccc cggtgccgcg ccggcccgcc gtgaacgtgc
      661 tgtcggccac cgccacgtcg tcgtcgacca gaacccgggc gacctggatg ccctcgtcct
      721 cggcgagttc ggcggccatg tcgaagttca gcacgtcccc ggtgtagttc ttcacgacga
      781 acagcacccc ggcaccgctg tcgaccgcgg cggccgcccg caccatctga tcgggtaccg
      841 gcgaggtgaa gatctcgccg ggacacgccg cggacagcat tccgggcccg acgaagcccg
      901 cgtgcagcgg ctcgtgcccg gacccgccgc cggacacgag acccaccttc ccggccaccg
      961 gggcgtcacg ccggaccacg agccgcttct cggtgtccac gacgagctcg gggtgggcgg
     1021 cggccattcc gcggagcccg tccgcgacga cggtctccgg cacgttgatg agcatgcgca
     1081 acggttcctc ctggggaaga gcatggcggc cggccgaacg aggtgaccgg ccgcaggcgt
     1141 ggatccggtc cttctgtctc aggtgcgtac ggcaccagta tcgaagagac ccgggtgatc
     1201 gggaagcgac gcgtcggagg gaaccgtccc gagccaccga cgaagggtga cttccccggc
     1261 acgatccgtc aggcccggcc ccagggcggc ttttcgagcc gcgtcgtccc tcatgcgtcg
     1321 tggagctgat gccatggtca tcctcgccgc gccacagtgc gggcgagcca ctcgtcgaag
     1381 gtctccgtcc cccggggccc cggcccggcc ggcagctgac cgttgccggc catggcggct
     1441 cccgcggcgc cgggcagtct caccggcacc accggcctgc gctcgccgcg ggcccggagc
     1501 agccgccgta ccaggtccac gagctgctcc tcccgcggcc cggcgagctc cggcgccatg
     1561 ccctgggccg gagcgagtgc cagatccacc aggtggcggg ccacctcccg ggccgccacg
     1621 ggctgcgtgc gcatccgggg caccacggcg agcggcttcg gcatctgatc cagggtctgg
     1681 ggcacgaact cgtggaactg tgcggcccgg agcacggtcc acggcacctg tccgcccctc
     1741 acgacctcct cctgccgcag cttgccctgg tagtagccgt gaccgacccg gtcgacgccg
     1801 atgaccgaga gcgccacgtg gtggcgtacc ccggcgcgtg aacccgcgtc cagcagattg
     1861 cggctggccg agccgaagaa ggagaccgcc ttgtcgcgac cgagagtcgt cctgttgctc
     1921 acgtcgatga ccgtctccac gcccaccagg gcggcgtcga gtcccgcacc cgagacgagg
     1981 tccacaccgc gcgaccgcgc cagcgtcacc gggtcgtgcc ctgccgcggt gagttcctcg
     2041 acgaccagcc ggccaaccgc cccggtgccg cctgccactg ctacccgcat gtcctgctcc
     2101 ttcgatcccg ttcggtcctg cgacggcgcg gcccggcatc ggcgtgcccg aaccgtgcct
     2161 cctgtctcca ggacggagcg ggccggcgcg gatgtgacat cgccggagcg cggccctcag
     2221 tcgcgcacac agagttcgcg gtcgcccagc caccggccga accagtcgct cagcggaagg
     2281 gtgacgcacc acccgggatc gttcgcgtcg ggagcgggca ccgtcggcgt gggtttgtcg
     2341 ggcttgggcg ccgtcggtgt cccgctcggg tcggcatcgg gcgagggcgt ggtggcatcc
     2401 ggcagcccgc tcagcatctc gcggaacacc tgggaggagt ggggattgtc ggcgcactgc
     2461 cacaccccgt gggggcagta gtccgtgatc gtctggtaca ccggcttgtg ccgctcgatc
     2521 cactccagca tgcggcgcat gtactcgggg ttgtcgccgt tgcggaacag cccccactcg
     2581 gggaacgaga tcggcttgcc gtgctcggcc gcgaagtcga cctgcttctg cagtccgtac
     2641 ggctcgttca cctgttcgtc gaaggtccgc gccggaggct ggtcgtagga gtccatgccg
     2701 atgatgtcca cgacgtcgtc gcccggatag cactccgtcc agggcacggc gtcccgcccc
     2761 ctgctcggcg cgaagtcgaa gcggaagtcc tggcccggca cggaacgcat cgcggtgacg
     2821 atgcgattcc agtacgcctt ccacgcgacg ggatcggggc cgcaccggtg tgtgtacgtc
     2881 gtcccgttca tctcccagcc gaggacgatc accgtgtcgg gaacgcccag caggaccaga
     2941 cgctcggcca gtctgcggaa gtgctcgtcg aactgcccgt aggcaccggc cctcagcaga
     3001 ccgcgcacct cgtcgtcgga gacacgctcc tcgttccgct ccagcatcgg cgtgttgagt
     3061 acgaacatcc ggtcctcgtc ggctttccgc cacgcggccc acgcggcgag gaagccggga
     3121 cggccctcga tgttctccca caggtcgccc ggcagatagc tgtgcccgac acgaagctcc
     3181 gtaccgccga gccagcgcga cagctccgcc atccgctgta cgccctgggg gccgtagtcc
     3241 aggtaggcgc cgatggcggt cgtcctgtcc ggttccggtg ccctctgagt ggcgcccttg
     3301 ccggcctggg tgtccgtggc gtcgtgatcg gcgaggaccg cgccgccgac gaggaggcag
     3361 agcgcggtcg ccccgatgcc gaaattgatg aaacggcgct gtacgggcac ggctcctcct
     3421 tggattgcgg cctgtccggc cttgtcgacc ctaaggagaa agattcaacg acgggctccg
     3481 ggaacggccg tgaatagacc attcgcgaca cgtgcaggct cagagcggac cattcgggtg
     3541 acgcacgtcg aaggtgaaag ggagggcacg cacccggttg tcgaaattcg aatcgatcag
     3601 accgggatca cccgaagcac ggaccccgtc cagccgcgtg agcatctcgc ggaagagagc
     3661 cttcatctcc agcttcgcca ggtgcgcccc cagacagtga tgaggacctc cgccgccgta
     3721 tccgaggtgc ggattcgggg accgggtgat gtcgaacgcg tccgggtcgt cgaagacgga
     3781 cgcgtcccgg ttcgccgacg catagaggag tacgaccttt tcccccggca gaaaagtgtg
     3841 gccgccgagt gcgcattcgg aagcaaccgt ccttcggaac tggatgatcg gagtcgagtg
     3901 ccggacgatc tcgtcgaccg ctccgtcggc gtagcggtcg aagtcggact ccaggagggc
     3961 cctctgatcg ggatgcgcgg tcagcaggac catcccgtgg gcgatggcgt tccgggtggt
     4021 ctccacaccg gccacgagca gcagcgagaa gaaggcgccg agctggcgcg aggacagggc
     4081 ctggccgccg acgtccgcgc ggacgagcgc cgagatgacg tcgtccgccg ggacgcggcg
     4141 ccgctctcgg gcgatgcccg ccatctccag ttgcatgcgg gccagggagc gcagtccgcg
     4201 ccccgggatc cgcagccgcg cgcggccacg cctccgtact ccgacgtact ccgacgcgtg
     4261 gtcgatccgt gcggcgattc cgggccggtg gcgtgcggga atgcccatca ggtcgcagat
     4321 gacctcgaac ggcatacggg agggcgccga gcgcatgaag tcgcccgggc cctccttgac
     4381 cacctcgtcg accagccgcc gggcgacggc accgatgttc tcctccgcct cggcgagcag
     4441 cctcggcgtg aaggcacggg agatggtcct gcgcagcccg gcgtgctcgg cgccgtccat
     4501 gttgaccatg gagttgccga acaccgcctt cgcccaaggc gccggttccg gcacggtcac
     4561 cccgggtgcg ctcgtgaaga cctgcggctg ccggctggcc gcctttacgt ccgcgtgctt
     4621 caccaacgcg cggaacggag tccgcggccc cgtccgagga gtgaagcgga ccggtgcgtc
     4681 gagctctctc agccgggcga acgcggccag ccgctcggac cgtggcagcc gccagaaggc
     4741 cgggtcggcc aggtcggcac cggccgcccc tcgcacgcgg tccgcggtca ccggtgtcgg
     4801 cgcttccatg ctcagcctcc gggagtcagg aggaccatgc tcgcccggcg ggaggcactc
     4861 ggcggccgac acgaccggac gggccggaca attcccacgg tcgcgtgatg tcctgcggat
     4921 gagaaccgtt cgcccccggt ctcgttgccc agtcgagcgg gacacctcgc agaagcggac
     4981 gagagggagg tacacccacc atgaacccga ccgaaggcac gtgcggggag ccggccggcg
     5041 ccccgcgggc ggcccgccgg gcggtgctgc gcaccgtctt caccgcggct gtggtcgccg
     5101 gcaccggcgg cgcactcgcc ccggtcctcc tcgggagtcc ggaccccgga ggccgcaccc
     5161 aggagcgcga cgcagtgggt cccgagcggt tctccgagct ctacaagggc cgggagatcc
     5221 gggggacggc cacgcccgtg gtgccggccg gcgcacagtc gcacgccggt gaggccgggg
     5281 ccgtcgccat gacccccggc atcgacgtca gtgtcgacgg acgtgccttg catgtgatga
     5341 ggcgcgccga cgggagctac atcagcaccg tcaaccacta cgagtcgttc ccgaccctcg
     5401 tcgagacggc ccgcgcggcg gtcgacgaac tcggcaccgc ccagttgtca gccgtctccc
     5461 cgcacatcat ctgagccctg aggacggagc acgggtgtac agccgcaaga atcagcgcga
     5521 cctcacgcgc accgagaaga aacgcctggt cgacgcgatc ctcgagctca aacgctcggg
     5581 acgctacgac gacttcgtca ccctgcacag gcagtactac gtcaccgaca cggagcgaag
     5641 gcctcggccc gcccacatga ccccgtcctt cttcccgtgg caccgcagat atctgctgga
     5701 gttcgagaag gcgctgaggg ctgtcgatcc ccgggtgacg cttccgtact gggactggac
     5761 gcgggacgac acggcgagcg cctccctctg ggcggaggac ttcctcggcg gaaacggccg
     5821 gccgggcgac cggcaggtca tgaccgggcc gttcgcctac cggcggggga actggcgtat
     5881 ccgcgccgga gtcaccgacg accccttcct gcggcgcgac ttcggccggc cctccgcgcc
     5941 cgtcaccctg cccggggcgg cggacgtgga ccgcgcgctg aaggatccgg tgtacgacgc
     6001 cgagccctgg aacagcgtca gcaccaccgg cttccgcaac aggatcgagg gctggggcat
     6061 caggggcgcc cgcggggtgg ccaaccacaa ccgggtgcac cgctggatcg gcggttcgat
     6121 ggcgggcgcg gcctcacccg acgacccggt cttctggctg caccacgcct tcatcgacct
     6181 gctctggacc cgttggcaga aggcgcatcc gcgctccccc tacctgccgg cccgcgcact
     6241 ccccgccgac gacccgcagc gggaccggat cttcgcgtcc gaccagccga tgccgccctg
     6301 ggacgtggcg ccctcgcagc tcatggacca cacccggttc taccggtacg tctgaggggc
     6361 gccggccgtc cccgcaacag atcctggcct cggcggaacg ggaacgggcc tccccctccg
     6421 cctggaagcg gagagggagg cccggtggtg cctcggcggg atcagtggcc gtagccgtgc
     6481 tcacccttgt tctcgtggct gtccgacacg ttcgcgcagg tgttgccgaa cgccgggttc
     6541 aggagggcga tcacgttcac cgtgttgccg cacacgttga ccgggatgtg gacgggcacc
     6601 tgcacgacgt tgcccgagag cacaccgggg gagtgcgcgg cgacggcctc cgccccggcg
     6661 tcggcaacgg ccatgccggc accgccggcg atcagggcac cggtgcctgc catcacggca
     6721 gccaccttcg agatacgcga catcagttct ccttgagggg atcggaaccg gctgcggagc
     6781 gtgcggccgg tatgccctga caacgcgaaa atcgacagac ggtaacggat cggctcaaaa
     6841 ctcatcatcc cgactcaact ccggcccagg accgcgagcc cggcagccgg aagctcgctc
     6901 agccggccac gccagtcccg cgctccggga aggcgggact tcaccgtttc cgcggcccgg
     6961 tcccgcacgg tcagctgagc ctcgcgcagc cgcaacagcg gctccagcgc ggaacgggcc
     7021 agcagcagac gctgattgac gacgggtacc ggtccccagt ggttcttgta ctgctccgag
     7081 ccacgcagca gactcagcac accgcgatcc gagccctccg tctcccgcgc gatctcgcgc
     7141 agcagcatcg aggagacgtc caccttcctc tccctgagca ggggatcggc accgtagagg
     7201 taacccccgg tcagctgcgc ggaccggaac gacaggtcgg cggccaccac ctccccgtcg
     7261 agaaggaact ccctgaccga ggcctcgccg tcgcgcacca tccggcgagc ggaccgcacc
     7321 aggtgcgcac agaagcgggg ccgcaggtgc tccggattga cccctctgcc gagccactgg
     7381 agttcgtgca gccgcagcag agtgccgacc gcgcccgcca cccggtggac gggcgccgtc
     7441 cggcactcga tgcccaacgc gtcgatcctg cgcagcttgg cccgggcccg ctgggcacgc
     7501 gaaccggtca tccgtccgat gagggcgtcg atcggctcgg cgggcaattc catgcaggtc
     7561 gagtccgagc ggctgctccg ggcgccggac catccctcga acagcaggtg cgccgaggcc
     7621 tcgggccgta cctcccgcaa gtccacgacc gcgtgcgcgg ctgcccggtg gaggccgtgc
     7681 cccagcgcgt cgaccgccgc ccgggtgtcc tcgccgtccg ccaggatgtc gaagaagtcg
     7741 gagatcgcgc cgcccatcgg caccagcaga ggcatcgggc ggtgcacgag catcaggggt
     7801 gccgcgccga tcaggcgtcc gccccggcgc gccagcagga cccggagccg gcccggggtg
     7861 ccgtaggaga gccaccacga gtggagccac gcgtgactct ggaagggcgt ggcagaggtg
     7921 cagcggcggt gcagcgcgtc ccactcgggg gcgagatccg cgaagtccgg cagatccctg
     7981 cagagggtga cggtgagccg cccgcgaagg ccggtgttca tcgcgcgagc tcccgttcgt
     8041 cggacgcgcc gccctgggcg ggggcgggta cctgggcggt gacaccccgg cggccggggc
     8101 gggggcggac gagaaggacc agcccgccca ccagcccgcc cacggaggcg cccacggccg
     8161 tgccgagcgg cgcggagggg gacaccggat cgaccggcgg cacggcgtgc gagaacttga
     8221 tcagcttcac gccggtgtcc ttcgcgacgt gtccgctgct gacgaccacg gcctcggtca
     8281 ccgcgttggc gatgtccgcg gcgcggtccc ggtccgccga cgtaccggtg accgcgatca
     8341 tgggcgagtc gggggaggtc tcggaccgca cgtgcccgcg gagctcacgg acgggttccc
     8401 cggcggcccc cttggcgtag gtgagggtgg cgtcgctggt ggccaggcgg ccgtacgact
     8461 gcgcgtagcc cagcgcggcg gcaggatcga tgtccttgcc ggcggtgacc atggcatagc
     8521 tggtggccgc gtactcgggc cgggcgagca ttccgtacga gaatccgcag gcggctccca
     8581 gaaggacgca ggcgggcagt ggccaccagg cgggccgtac gaatgcgggg cgcagcctgc
     8641 ggaagcgtcc gatgacggac ggctgctgct cgggcgagtc ggtcatgggt gaactctctc
     8701 ggtcgggggg aggggggcgg tggcgacggc ctgtgcgtag acgtccatga ggcgccggct
     8761 gctggacctg atgtcgtagg cgtccacgac gggaggcggc ggcagcctgc gggtgccgct
     8821 ctccacgtgg tgccgcagcg cggctgtcag ctcctccgcc ggaccggtcg tgccggaggc
     8881 ggagccgata cgcgtggtgc ccggcacccg gcccgccggg aggtcctcga ccgcggggca
     8941 ggccgcgtgc accacgggca gtccggcggc cagggcctcg acgacggcaa ggccgaagga
     9001 ctcctcgcgt gacgccgaga cgaagatgtc gacggcactg agcaccgcgg gaatcgtggg
     9061 agcggcgccc gcggtgccgc actcgccgag gaacctgaca cggccggcca caccgagccg
     9121 ggcggcgaga gcacgcagcg gcacggcctc cggtccgtca ccggccagta cgagccaggc
     9181 accggggagg gcggcgacgg caccgatcag cagatcgaag cgcttcccgg gcaccagcct
     9241 gcccacgccc cccaccacga aggccgcatc ggggagtccc agcagggccc gtgtggagcg
     9301 ccgttgcgcg ctgtcgaagc ggaatgccgc cgcatcgata ccgttgggca ccgtatggat
     9361 ccgggcggcc ggcacacccc agtcgcgcag cctgcccgcg acggtgtcgg acacggcgac
     9421 ggtcgccgct ccgagccgct cggtgcgcag atagagctcc cgggtgcccc gggtgagcgg
     9481 ccgtccctcg atctccgcgt gccccagtga atgctccgtc gccaccaccg tggccccggc
     9541 gaggcgcgcc gcgatccggc cgtagacaca ggcccggtag agatgcgtgt gcacgaggtc
     9601 gtacgaaccg cggcggatga gccgggccag ccggggcacg gcgccgaggt cccggttgct
     9661 cctcatcccc aggtcccgca cccggacgcc gtccgcccgc agcccttccg cgaccgctcc
     9721 cgggttggtg agcgtcacga cgtcgcagcg caccggcaga tggcgcagca gcagccgcag
     9781 ctgctgctcg gccccgccga ctccgaggcc ggtgatgatg tgcagcgcct tcacctcgcg
     9841 tcaccctgcg ccgccgggcc ggcggagcgg tgcagcagcc tgtgccgtac ctccttggcc
     9901 cgcagacggg cgcctcggtc ggcgtggctg acatgcgtgc ggggaagggc gagcgggccc
     9961 gagagcgcgc cgggggcgag ggcgcagccg taggcgtatc ccgcttcccg tacggactcg
    10021 accaccctcc ggtcgaccgt gccgtacggg tagcagaagc ctgacggcgt ctgcccgacg
    10081 atgcgggtga gcgcgtccct gctgccgtgt gtctccctgc gcagttcgtc gtcgggcagt
    10141 gccgtcaggt gccgatggag catcccgtgg gagccgacct ccatgcccgc cgccgcgacg
    10201 gtacggatgc cctcctcggt gagcagcggt ctgcgcgggc cgagcggatc ccaggcgttg
    10261 gagcccccgg gacggccggg caggacgaac accgtcgcgg tgcagccgtg agcgagcagt
    10321 accgggagcg cctcgtcgag gaagtcggcg tacccgtcgt cgaaggtgag cccgaccagc
    10381 ccccggtccc cggtggtccg cgcgcccagc agcgtcgcga cgcccacgcc ggtcagccct
    10441 cggcgccgca gccaggtcag ctgctcgtcg aggc
//
