LOCUS       NZ_CAKMXI010000007     21152 bp    DNA     linear   CON 03-JUN-2024
DEFINITION  Streptomyces atroolivaceus strain TUE2108, whole genome shotgun
            sequence.
ACCESSION   NZ_CAKMXI010000007
VERSION     NZ_CAKMXI010000007.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces atroolivaceus
  ORGANISM  Streptomyces atroolivaceus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 411765)
  AUTHORS   Wibberg,D.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-FEB-2022) CEBITEC, Genome Research of Industrial
            Microorganisms (GRIM), Universitaetsstrasse 27, 33615, NRW, Germany
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_928722305.1-RS_2024_06_03
            Annotation Date                   :: 06/03/2024 04:23:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,057
            CDSs (total)                      :: 6,983
            Genes (coding)                    :: 6,683
            CDSs (with protein)               :: 6,683
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 2 (5S, 16S)
            complete rRNAs                    :: 1, 1 (5S, 16S)
            partial rRNAs                     :: 1 (16S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 300
            CDSs (without protein)            :: 300
            Pseudo Genes (ambiguous residues) :: 0 of 300
            Pseudo Genes (frameshifted)       :: 123 of 300
            Pseudo Genes (incomplete)         :: 254 of 300
            Pseudo Genes (internal stop)      :: 20 of 300
            Pseudo Genes (multiple problems)  :: 87 of 300
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:59:12
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 24025
            Orig. end                         :: 45177
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CAKMXI010000007.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21152
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="2"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21152
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21152
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11152](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11152)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            complement(345..1508)
                     /locus_tag="NBY68_RS18345"
     CDS             complement(345..1508)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014140868.1"
                     /locus_tag="NBY68_RS18345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_250290161.1"
                     /transl_table=11
                     /translation="MNSTPTTPPRPFDVTAAFPQLAPLARTATRLHPRPGSPSPQDSSI
                     GGPLLWPADEPWPHCDGPHVVDGMNEALSPADVRLERQIHAASSGRGLTPREREALERI
                     RPPRKLPLRVAVAPYEGSIAMLPVAQLYLRDVPDLHAPGGADLLQVLWCPFDHPIMPRT
                     ALFWRSAATVTDILTAPPEPPAMQFDGYLPEPCLLNPEQVTEYPDHLELSKELQEQLGN
                     WGVWQAADTDVDSAYASYPQEFYDLELAGAPGWKVGGWPRWGATDPTPRLCPACGSDMD
                     ALLTIATFEADDDSSWLPNEVCEEREHSSPSPSSTGPEGQAVVDFFHAQGIEVHNRGRV
                     ARDVRVAPLGTDPVPRKPTAVQIGSGYDQQLYVCPAAPEHPHSELMH"
     misc_feature    1801..1814
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.6"
                     /tool="antismash"
     misc_feature    complement(1802..1815)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.09"
                     /tool="antismash"
     gene            <2145..>2405
                     /locus_tag="NBY68_RS18350"
                     /pseudo=""
     CDS             2145..>2405
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018099752.1"
                     /locus_tag="NBY68_RS18350"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="coagulation factor 5/8 type domain protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MYYAVKKAYAGSTSRDNTPPVITNTGVTPASATPAGKEFTIRADV
                     RDPDGDPVTYKILLSANYASGDRGLVEARWRSTGKGTFAVTA"
     gene            complement(2536..3861)
                     /locus_tag="NBY68_RS18355"
     CDS             complement(2536..3861)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1108: ROK family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017237401.1"
                     /locus_tag="NBY68_RS18355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ROK family protein"
                     /protein_id="WP_250290162.1"
                     /transl_table=11
                     /translation="MKVRSGRTVRDLRRENRTAVLQRLYFDGPLSRFSLGPLTGLSSGS
                     VSNVVAELVTEGLVEEAGSVDSAGGRPRTLLRIRPQSRYMIGVDIGETRVRVELFDLAL
                     TELARVEKPLSLDGPRRVDRYDVGVVVGHVRAGVTEVLDRAGIAADRLLGVGVGVPGIV
                     SRTPEDGAVVHGQTIGWDAVPLERLLRESVPLPANVLYYIDNGAKTLGQAEMWFGAGRG
                     AQSAVVVLFGSGVGACVVTDDMSPGRAVEWGHLTVRVRGRRCRCGALGCLEAYAGAEAL
                     LERWREAGGEPLADVDEETALTAMLAAAYPAGQGDEAGPGSDATALAVLEETAEYLGAG
                     FSDLINLFQPERILVGGWAGLQLGTRFLDSVRAHATSYALAYPAAHVQIGLGTLGPDAV
                     TVGAAALPLADFFERGGRQEEAGPQEQAPVWQTTLQDRAAHR"
     gene            4046..5362
                     /locus_tag="NBY68_RS18360"
     CDS             4046..5362
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014044258.1"
                     /locus_tag="NBY68_RS18360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sugar ABC transporter substrate-binding protein"
                     /protein_id="WP_250290164.1"
                     /transl_table=11
                     /translation="MRRIRAAAVGAVTLSLVLTAAACGGGSSGSGGSNDQPKTLTYWAS
                     NQGASLEVDKKVLQPELDKFEKETGIKVKLEVVPWGDLLNRILTATTSGQGPDVLNIGN
                     TWSASLQATGALLPWDEKNFEAIGGKDRFVESALGSTGVQGEDPAAVPLYSMAYALYYN
                     KKMFADAGIQKPPTTWDEVAEAGKKLSKDGKWGLGAEGSNLSNNIHQVFVLAKQHGADF
                     FTAEGKADFTSDGAVAAVKQYVDLMAKDKIIAPGNAEYAQNQSLSDFAKDKTAMVLWQT
                     AAATFESQGMKKEEWDVVPAPVQSGKPGTGKGTNSMVAGINMAVFNNTKNIDGAKKFVK
                     FMTSDEEQTVLNKAYGSIPPVKAAQEDDAFNTFALSPLRETLATSAAALPQVPEESQFE
                     TVVGTAVKELFADAAAGRPVTTASVKAKLEKAQQQMPEK"
     gene            5377..6372
                     /locus_tag="NBY68_RS18365"
     CDS             5377..6372
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005308068.1"
                     /locus_tag="NBY68_RS18365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sugar ABC transporter permease"
                     /protein_id="WP_250290166.1"
                     /transl_table=11
                     /translation="MTTTAAPIPGERTAEKKSPGAAPRRRRSGRLRKIGLPYLLLLPAL
                     LLELLVHLVPMIIGIVVSFRQLTQFYIRDWATAPWAGFDNYAVSVDFDAPVGEALVQSF
                     LTTCLFTLLSVSLCWFLGTAAAVFMQETFRGRGFLRTLFLVPYALPVYAAVITWAFMFQ
                     RDNGIINHVIHDQLGLTDSPPFWLIGDNAFVTLLVVSVWKGWPFAFLIMMAGLQNIPRD
                     IYEAAALDGAGVWQQIRRITLPSLRPVNQVLVLVLFLWTFNDFNTPFVLFGKAAPASAD
                     LISIHIYQSSFQTWNFGTGSAMSVLLLLFLLVVTGLYLLFTSRGKQATDA"
     gene            6404..7243
                     /locus_tag="NBY68_RS18370"
     CDS             6404..7243
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019328255.1"
                     /locus_tag="NBY68_RS18370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_250290168.1"
                     /transl_table=11
                     /translation="MAPPQSFLWARRIFLTLLTVFVVLPVFVMITSSLKPLEDVTGKFQ
                     WIPSGLTISPYFDIWDTVPLADYFMNSLIVAGAATVCSVVIAVFAAYAVSRYNFRGKRV
                     FTVTVLSTQMFPGILFLLPLFLIYVNIGNATGIALFGSRAGLIITYLTFSLPFSIWMLI
                     GYFDSVPRDLDEAAKVDGCGPLGALFRVIVPAAIPGIVAVAVYAFMTAWGEVLFASVMT
                     NDTTRTLAVGLQGYSTQNDVYWNQVMAASLVVSLPVVAGFLLLQRYLVAGLTAGAVK"
     gene            7300..8655
                     /locus_tag="NBY68_RS18375"
     CDS             7300..8655
                     /EC_number="3.2.1.21"
                     /GO_function="GO:0008422 - beta-glucosidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0030245 - cellulose catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014044255.1"
                     /locus_tag="NBY68_RS18375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GH1 family beta-glucosidase"
                     /protein_id="WP_250290170.1"
                     /transl_table=11
                     /translation="MSEPIDLAAFPRDFVWGTATAAYQIEGGVAEDGRSPSIWDTFSHT
                     PGKVANGDHGDEACDHYHRWPEDVALMKRLGVDSYRMSTAWPRVVPGGDGPVNAPGLDF
                     YDRLVDGLLDAGVTPNITLYHWDLPQALQDRGGWTVRDTAEHLAAYAAVVAERLGDRVT
                     RWATLNEPLCSGWIGHLEGRMAPGLTDLSAAVRASYHLLLGHGLATQAIRAASPGAQVG
                     LVTNHSTVEAASSRPEDLAAAVRMDGHTNRWWLDPVYGRGFPTDMRELYGVELPECAGD
                     LETMAAPLDWHGLNYYFPVTVADDPEGPVPHAREVRLPDVPRTGMDWQIDAGGLEALLM
                     RLTDDYGVGRLYVTENGSAFPDTVGPDGAVDDPERTRYLEQHLAACARAVRKGAPVAGY
                     YAWSLLDNFEWAYGYDKRFGLVHVDYPTQTRTIKSSGHRYADVIRTHRGTRA"
     gene            complement(8777..9061)
                     /locus_tag="NBY68_RS18380"
     CDS             complement(8777..9061)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013224.4"
                     /locus_tag="NBY68_RS18380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Lrp/AsnC ligand binding domain-containing
                     protein"
                     /protein_id="WP_250290172.1"
                     /transl_table=11
                     /translation="MRIRPPARPVIEGFRERAARLPEVLGLFVTSGTHDFLLRIAVPDV
                     DGVYAFDRLTERRGSPTCRPPGPMSTSSPAASSRTATIGPASHAGPADR"
     gene            complement(9181..9423)
                     /locus_tag="NBY68_RS18385"
     CDS             complement(9181..9423)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008414644.1"
                     /locus_tag="NBY68_RS18385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6411 family protein"
                     /protein_id="WP_250290174.1"
                     /transl_table=11
                     /translation="MMIVGIVAVCVVLAVLAFLVPRLSRHPERGTQRTLGAGSRAGGKA
                     PGVLGRIFSKPFRSSSKAVGNSGSAGRRARGRMPF"
     misc_feature    9412..9425
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.88"
                     /tool="antismash"
     gene            <9710..>9841
                     /locus_tag="NBY68_RS18390"
                     /pseudo=""
     CDS             9710..>9841
                     /GO_function="GO:0008703 -
                     5-amino-6-(5-phosphoribosylamino)uracil reductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018896093.1"
                     /locus_tag="NBY68_RS18390"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="dihydrofolate reductase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRSHGSLSMNRALTAAGPVDRVQVTLFPVITGRTGLDPVFRGAA"
     gene            complement(10001..11152)
                     /locus_tag="NBY68_RS18395"
     CDS             complement(10001..11152)
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010033177.1"
                     /locus_tag="NBY68_RS18395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_250290176.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 6.5e-59, bitscore:
                     193.8, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSPVTASAGTVRDAAPAGSARKAAPAGDVTPPDAASSEPSATAP
                     GILARCRDLVRPSLSAAVGRLHPWPGEMAAYSLGWCEVGGTPADGSFEGKGVRQALAVL
                     CAEAAEAPGESAVAGAVAVELIHTFSLLHDDIMDGDGTRRQRQTVWKAYGTGPAVLAGD
                     ALFALAVQTLAETPGPHTAAAVGRLSGTLGGLVHGQAEDLLFAARPWTGPEAVWPDEYR
                     AMAELKTGTLLGCAAALGGLLGGAPARTVAALDRAGRHLGVAFQVIDDLLGIWGDPAVT
                     GKPVHSDLRQRKKTYPVLAALAGDGRRARELAGLLDSPLGLDDAGAVRAAALVEACGGR
                     TATVAEAGHHLDAARACLRSVPLAPRAAREIDVLLGFLLHRRL"
     gene            complement(11149..12237)
                     /locus_tag="NBY68_RS18400"
     CDS             complement(11149..12237)
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015576034.1"
                     /locus_tag="NBY68_RS18400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_250290178.1"
                     /transl_table=11
                     /translation="MTQQDRPKGKAFAPEYQGALGSLSVNSSLSEVLAKGVEELRAAER
                     AGEHREMARCGLAVAEAYRRLGRVADADAAWKSSYRAARSAEDVGAMAWALWSGGTLAR
                     QRGSLALAYRLLGLAAEMGERGGDVVVRGYSLAGLAETGRIQGDYQAVGELHEQLLAEA
                     RRRGEARHTVWALEGIAQMHRNTGSYDRALALFEEAAETAHRADDRRGRAWALRGIADV
                     VSVRDGDVERALALLTEAESVCREMKLSSALAYNHKMRANVHYRAGQYPQARETYAQAL
                     AEFEEMNEPRGTALSRLGLAKSLARLGRNPAETVVELAGLRRTLDRIGLKHARDMVDKA
                     AEELGVGPLPGVGHRTEEAVTR"
     gene            complement(12623..13123)
                     /locus_tag="NBY68_RS18405"
     CDS             complement(12623..13123)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007261908.1"
                     /locus_tag="NBY68_RS18405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_250290180.1"
                     /transl_table=11
                     /translation="MRSHDVLLSELRRSMAALSTEGRVYVRAGRYAESAPDMAELTAQI
                     RALLTQVFEDPAWKRFLAPAVPPAAGAVEGSLELIEAGTAAGLLTSVASVDIVWPSHAL
                     MDHAVAARTAKRVVSLLGSDATWWTNHDSDCGAVNLLTPVFDSLIAGTDGTYYAIAVQV
                     ADD"
     gene            complement(13365..13985)
                     /locus_tag="NBY68_RS18410"
     CDS             complement(13365..13985)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003967257.1"
                     /locus_tag="NBY68_RS18410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF1707 domain-containing protein"
                     /protein_id="WP_250290182.1"
                     /transl_table=11
                     /translation="MTAQLPEPSPRPAAPSELRASHDDREAVVERLRDAAAEGRIDLDE
                     LDARLEQALTSKTYAELAVLTADLPQLNSSENRPPLVLKGGMNGASRGPGRWEVPGRVV
                     AHGGWGGVKLDFSRVQCRLNEIAVEAYGEAAGVTVVIPDAWAADTSGMDPGIGGLTDRT
                     TPDRLPGTPLIRLTGSGGVSGVVIRHPSRWERRKLRSNPTDQI"
     misc_feature    complement(14099..14117)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 24.84"
                     /tool="antismash"
     misc_feature    14100..14120
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 20.34"
                     /tool="antismash"
     misc_feature    complement(14101..14121)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 28.67"
                     /tool="antismash"
     gene            14133..14351
                     /locus_tag="NBY68_RS18415"
     CDS             14133..14351
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1009: mbtH-like protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014157798.1"
                     /locus_tag="NBY68_RS18415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MbtH family protein"
                     /protein_id="WP_250290183.1"
                     /transl_table=11
                     /translation="MTNPFEVENGTYLVLVNDEGQHSLWPAFAEVPAGWTVAHQEDTRQ
                     ACLEYVERNWTDLRPKSLIRSMAAGPA"
     gene            complement(14546..15646)
                     /locus_tag="NBY68_RS18420"
     CDS             complement(14546..15646)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956425.1"
                     /locus_tag="NBY68_RS18420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="winged helix DNA-binding domain-containing
                     protein"
                     /protein_id="WP_250290185.1"
                     /transl_table=11
                     /translation="MTVLDSRALNRATLARQLLLDRAGLPVLDAVGHLGGLQAQEPQEP
                     YVGLWSRLRTFEPASLSDLLVRRSVVRVHLMRRTVHLVTAEDAVAWRARHGAMLRQRVL
                     GVYRREFDGTDLDELAEAGRAVLADGKPRSAAELVRELTVRWPKPGRRALGEMVVAALV
                     PVAQTPPRGLWRTDAGVRNVLLSSWLGRSIDPPVLDPSDPVGQTLVRRYLAAFGPAASA
                     DLRAWCGLAGLPAAVKALREELVSFRDERGRELLDLPGAPRPDPGTPAPVRFLPAFDNA
                     ILGYHDRGRIIDDAHRGLSVAGERVVLVDGRVAATWSVDVGTVVVTPLRGLSRPDRDSV
                     AEQGSELASFLSDGESSRVRIAVPAC"
     gene            15814..16815
                     /locus_tag="NBY68_RS18425"
     CDS             15814..16815
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019993458.1"
                     /locus_tag="NBY68_RS18425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="WYL domain-containing protein"
                     /protein_id="WP_250290187.1"
                     /transl_table=11
                     /translation="MARTSARLLFLLSLLQARRDWPGQVLAERLEVSPRTVRRDVDRLR
                     ELGYPVVAAKGPDGGYRLDAGAELPPLLFDDDQAVALAVALRTAATTGAGIEEAAARAL
                     NTVRQVMPARLRHRVDALHVTAVGPAETQPGPQADPRVLVALSEAVHAREVLRFDYTVE
                     NSEAGHSDAVKPPRRAEPHHLVTWRGRWYLLAWDLDRDDWRTFRADRIAPRTPRGPRFT
                     PRDVPGGDVAEFVAGRFQGSGSGGDWPCRGEVILDLPAPVVSRYSRDGVVEALGPDRCR
                     LLLGAWSWPGLAATIGRFDADFQVVGPAELKDACANLARRYADAATREPPGI"
     gene            complement(16955..17974)
                     /locus_tag="NBY68_RS18430"
     CDS             complement(16955..17974)
                     /GO_function="GO:0015293 - symporter activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014044396.1"
                     /locus_tag="NBY68_RS18430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bile acid:sodium symporter family protein"
                     /protein_id="WP_250290189.1"
                     /transl_table=11
                     /translation="MQTEQISPDQPASDDRAARRAVTVFPVLVLVAGVAGLVTPGTFDG
                     WTGSVPYLLGIVMFCMGLTMTPLDFRGVVKRPWAVAIGLVAHYVIMPGLGWAIAHLLQL
                     PPQLAAGLILVGCAPSGTASNVVTFLARGDVALSVSVATVSTLVAPLVTPPLTLLLAGA
                     YLPVDAGSMITDILKTVLLPILGGLVVRLVAGKFVDRVLGLMPWLSSLAIAAIVCAVVA
                     GSASMIKSAAVSVLIAVVLHNGLGLALGYGAGKVSGLGRPASRAMAFEVGMQNSGLAAS
                     LATAHFSPLAALPAAVFSVWHNISGALVAAWMSHRSRRDEPVPVAAGPTPKARAAEES"
     gene            complement(18078..19697)
                     /locus_tag="NBY68_RS18435"
     CDS             complement(18078..19697)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015576031.1"
                     /locus_tag="NBY68_RS18435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="WP_250290191.1"
                     /transl_table=11
                     /translation="MSDIPSAALLARDVVRSFGTGRVVDGFSLTASPGHRIGLIGENGV
                     GKSTLLRLLAGADEPDAGIITRPADLGFLHQEMPFDTAATIADVLDEALREVRDELAAL
                     EHLSGRLACAQEDSPDYAGLLEAYGRRLERAREQEAWDADRRATIVLEGLGLGGIRRDR
                     ALDSLSGGQRGRLALASLLVRRPSALLLDEPTNHLDDRAAEFLEEQVRGLSGAVVVASH
                     DRAFLDAVCTDLVDLDPAVDGPVRYGGNYSAYQAEKRAERERWERRYAEEQEELEALRL
                     SAGTTARRVAPDRGPRDNEKMGYGVRAGRVQSQVSRRVRNAARRLDELERHRVAQPPLP
                     LRFRRDALAGPSGDGTLVSLRGVRVRDRLAVDRLDVSATERLLVTGDNGAGKSTLLAVL
                     AGHLTADTGEVRRRGGLSVGLLAQDTVFDRPDRIVRDTYAHALGDERAEAVPLSSLGLM
                     AEADLGKQVGRLSVGQRRRLALALLVAHPPELLLLDEPTNHLSPQLCDELEDAMGAGPG
                     AIVIAGHDRRLRSRWQGRGIHL"
     misc_feature    20157..20167
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
ORIGIN
        1 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
       61 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnccgca
      121 tggtctgagc cggcgccctc attccggccg gttgctgtga cccgcggcaa ccggccggaa
      181 tgacgtcgtc ggattccttg ctgcgcagtc acttccgggt gacgggcgtc gagaaacatc
      241 ggaacggaac cggcgacaga cttcgttctg gagacgggct accgggacgc gtgccaccgc
      301 ccggctgctg ccccgcccgc tcaagggccg tacgcgcggg ccggctagtg catcagctcg
      361 gagtgggggt gctccggcgc tgccggacag acgtagagct gctggtcgta gccgctgccg
      421 atctggacgg cggtcggttt cctcggaaca gggtcggtgc cgagcggcgc gacgcggaca
      481 tcgcgggcga cgcggccgcg gttgtgcacc tcgatgcctt gggcgtggaa gaagtcgacc
      541 acggcctgac cctccggccc ggtgctgctg ggcgacggac tggagtgttc tcgttcttcg
      601 cagacttcgt tcgggagcca gctgctgtcg tcgtcggcct cgaaggtggc gatggtcagc
      661 agggcatcca tgtcgctgcc gcaggcagga cagagccggg gcgtggggtc ggtggcgccc
      721 cagcgaggcc agccgccgac cttccagccg ggtgcgccgg ccaactcgag gtcgtagaac
      781 tcctgcgggt acgacgcgta ggcgctgtcc acatccgtgt cggctgcctg ccacacgccc
      841 cagtttccga gctgctcctg tagctccttg ctcaactcca ggtggtcggg gtattcggtg
      901 acctgctccg ggttgagcag gcacggctcg ggaaggtagc cgtcgaactg catcgcgggc
      961 ggttcggggg gcgcagtgag gatgtcggtg acggtggctg ccgaccgcca gaacagcgcg
     1021 gtcctgggca tgatcgggtg atcgaaggga caccacagga cttggagcag gtctgctcct
     1081 ccaggcgcgt gcagatcggg cacgtcccgc aggtacaact gtgcgaccgg cagcatcgct
     1141 atggacccct cgtacggcgc gacggccacc ctcagcggaa gtttccgggg agggcgtatt
     1201 cgctccaggg cctcccgctc gcgcggggtc aggcccctgc cgctcgaggc cgcatggatc
     1261 tgccgctcca gcctcacgtc cgccggggac agagcctcgt tcattccgtc caccacatga
     1321 ggtccgtcgc agtgcggcca cggctcgtcg gcgggccaca gcagcggtcc gccgatggaa
     1381 ctgtcctgcg gtgacggaga cccggggcgg gggtgcagcc tggtcgccgt gcgcgccagc
     1441 ggagccagct gagggaatgc cgcggtgacg tcgaacggcc gcggtggcgt ggtcggagtg
     1501 ctgttcatag ccgggatcct gccaactcac actgacaacg cgctcagcca cctcggagca
     1561 acctctcccc aggcgaacct cgcaggggtg acctgaacgt ctgaggtact catcgcgaag
     1621 gcactcggct cccacacagg acgactaccc gcctggtcac cgcagcagca tctcgatgct
     1681 tcccattcgc ggatgctact gccccgagga ctcgaagacc gccggcacgg cgatcaagaa
     1741 ctcgaagctg cgaccggact gcgggacggg gcactcactg gtgtgctgaa cggtggctcc
     1801 atcactcaac gtgatcgact gccatcggcc ggagcatacg cgacaccgga acatgtgacc
     1861 tcaccggttc aacccccgtg acgcgcagcc gttgcaccgg gcgctctgct gttccgccgc
     1921 ccgtgtgacc ggtgtgccgg ggcggatcgg gggcagaagc cgtgacgttc acccctgcga
     1981 gcaggggtga aggggcgcgc ctgaaacctg gggaggtcga gggcgcgccc tcgcgttcgg
     2041 ctcactgaag gacggatggg cccggcgtcc cgacccggcc ggtccggttc gggcgtggcc
     2101 ggccggtgct cgatgcttgc cgcgccccac ccgtgcggtc aaggtcgtac tacgcggtga
     2161 agaaggcgta cgccgggtcg acgagccggg acaacacgcc acccgtcatc acgaacacgg
     2221 gggtcactcc ggcttccgcc accccggcgg gcaaggagtt cacgatccgt gcggacgtgc
     2281 gggacccgga cggcgacccg gtgacgtaca agattctcct gagcgccaac tacgccagtg
     2341 gcgacagggg gctcgtcgag gcccggtggc ggtcgaccgg taagggcacc ttcgccgtca
     2401 ccgccacggg gcggccgggc cctgcccccg cacgtacgct ccggaccgga cgggaccgac
     2461 gcgaagcgcg gtccggaccg gacgtgacgc agggccctct ctctcctgcg cggccgggag
     2521 gccccggcgc gcgtctcacc ggtgcgctgc ccggtcctgc agcgtcgtct gccacaccgg
     2581 tgcctgctcc tgggggcctg cctcctcctg tcggcctccg cgctcgaaga agtcggcgag
     2641 cggcagggcg gccgccccca cggtgacggc gtccggcccc agggtgccga ggccgatctg
     2701 cacgtgggcg gccggatacg cgagggcgta cgaggtcgcg tgggcccgga ccgaatccag
     2761 gaaccgggtg ccgagctgga gccccgccca gcccccgacg aggatgcgct cgggctggaa
     2821 gagattgatc aggtcggaga agcccgcgcc gaggtactcc gcggtctcct ccaggaccgc
     2881 cagggccgtg gcgtcggagc ccggtccggc ctcgtcgccc tgtccggccg gatacgccgc
     2941 ggccagcatg gccgtgagcg cggtctcctc gtcgacgtcc gcgagaggct ctcctcccgc
     3001 ctccctccag cgctccagca gcgcctccgc gcccgcatac gcctccaggc agccgagcgc
     3061 gccgcagcga cagcgcctgc ctcgcacccg cacggtcaga tgcccccact cgacggcccg
     3121 gcccgggctc atgtcgtcgg tgaccacgca ggcccccaca cctgagccga acagcacgac
     3181 cacggcgctc tgcgccccgc gcccggcgcc gaaccacatc tcggcctggc cgagcgtctt
     3241 ggcgccgttg tcgatgtagt acagcacgtt cgccgggagc ggcaccgact cacgcagcag
     3301 acgctccagc ggcaccgcgt cccagccgat ggtctggccg tgcaccacgg cgccgtcctc
     3361 gggcgtcctg gagacgatgc ccggcacacc gacgccgact ccgaggagcc ggtcggccgc
     3421 gatcccggcg cggtccagga cctcggtgac gcccgcgcgt acatgcccca ccacgacacc
     3481 gacgtcgtag cggtcgacgc gccgcggtcc gtcgagcgac aggggcttct cgacgcgtgc
     3541 gagctccgtg agggcgaggt cgaagagttc gactctcacc cgggtctcgc cgatgtcgac
     3601 accgatcatg taccggctct ggggccggat acgcagaagg gtccgaggcc gcccgcccgc
     3661 ggagtcgacg ctgccggcct cctcgaccag cccttcggtg accagttcgg ccaccacgtt
     3721 gctcacggag ccggaactca gcccggtgag cgggccgagc gaaaaacggc tcaacgggcc
     3781 atcgaaatac aaacgttgca atacggcggt gcggttctcg cgccgcaggt cacgcaccgt
     3841 tcggccgctg cgtactttca ctctgccccc tcttcctgaa gctcacctct gcaacatacc
     3901 gccgcgacac ctcttgacgc gaccttcact tggggtttaa ctcacaccct aaattaagcc
     3961 gtgtgggttt gtggtcgaac agggaacgtc gttccgaccc gggtccgcgg cggacatccg
     4021 tcacttctga aaggcccctg gagtcatgcg cagaatccga gccgcggccg tcggtgccgt
     4081 caccctctcg ctcgtactca ccgcggctgc ctgcggcggc gggtcgtccg ggtcgggcgg
     4141 atccaacgac cagccgaaga cgctcacgta ctgggcctcg aaccagggcg ccagcctcga
     4201 ggtggacaag aaggtcctgc agcccgagct cgacaagttc gagaaggaga cagggatcaa
     4261 ggtcaagctg gaggtggtgc cctgggggga cctgctgaac cgcatcctca ccgccaccac
     4321 ctccgggcag gggccggacg tcctgaacat cgggaacacc tggagcgctt cgctgcaggc
     4381 caccggtgcg ctgctgccct gggacgagaa gaacttcgag gcgataggcg gcaaggaccg
     4441 cttcgtcgag tccgccctcg gctcgaccgg tgtccagggc gaggacccgg ccgccgttcc
     4501 cctgtactcc atggcctacg cgctctacta caacaagaag atgttcgccg acgccggcat
     4561 ccagaagccc cccacgacgt gggacgaggt ggccgaggca gggaagaagc tgtccaagga
     4621 cggcaagtgg gggctcggcg ccgagggctc caacctctcc aacaacatcc accaggtctt
     4681 cgtcctggcc aagcagcacg gggccgactt cttcaccgcc gaaggcaagg cggacttcac
     4741 gtccgacggg gcggtggcgg ccgtcaagca gtacgtcgac ctcatggcca aggacaagat
     4801 catcgcgccc ggcaacgccg agtacgcgca gaaccagtcc ctgagcgact tcgccaagga
     4861 caagacggcc atggtgctct ggcagaccgc ggccgccacc ttcgagtccc agggcatgaa
     4921 gaaggaggag tgggacgtgg tgcccgcccc ggtccagtcg gggaagcccg gcacgggcaa
     4981 gggcacgaac tccatggtcg ccggcatcaa catggccgtc ttcaacaaca ccaagaacat
     5041 cgacggcgcc aagaagttcg tgaagttcat gaccagcgac gaggagcaga cggtcctgaa
     5101 caaggcctac ggctccatcc cgcccgtcaa ggccgcccag gaggacgacg cgttcaacac
     5161 cttcgccctc tcacccctgc gggagaccct cgccacgagt gccgccgccc tgccccaggt
     5221 ccccgaggag tcgcagttcg agaccgtcgt cggcacggcg gtcaaggaac tcttcgccga
     5281 cgcggccgcc ggccggccgg tgacgaccgc atcggtcaag gcgaagctcg agaaggccca
     5341 gcagcagatg cccgagaagt gagcacggac accaccatga ccacgaccgc cgccccgatc
     5401 cccggcgagc ggacagcaga gaagaagagc cccggagcgg cgccgcgcag acgccgctcc
     5461 gggcggctgc gcaagatcgg cctgccctac ctgctgctgc tccccgccct gctcctcgaa
     5521 ctgctggtcc acctggtgcc catgatcatc ggcatcgtcg tcagcttccg gcagctcacc
     5581 cagttctaca tccgggactg ggccaccgcg ccctgggccg gtttcgacaa ctacgccgtc
     5641 tcggtcgact tcgacgcccc ggtgggcgag gcgctggtgc agtcgttcct gacgacgtgc
     5701 ctgttcaccc tgctgtcggt gagcctgtgc tggttcctcg gaaccgccgc cgcggtcttc
     5761 atgcaggaga ccttccgcgg ccgaggcttc ctgcgcacgc tcttcctcgt gccgtacgcc
     5821 ctgcccgtgt acgccgccgt catcacctgg gcgttcatgt tccagcgtga caacggaatc
     5881 atcaaccacg tcatccacga ccagctcggc ctcaccgaca gccctccgtt ctggctcatc
     5941 ggtgacaacg ccttcgtcac gctgctcgtc gtctcggtgt ggaagggctg gcccttcgcc
     6001 ttcctcatca tgatggccgg cctccagaac atcccccggg acatctacga agcggcagcg
     6061 ctcgacggcg ccggggtgtg gcagcagatc cgccgcatca ccctgccgtc actgcggccc
     6121 gtcaaccagg tcctcgtcct cgtgctgttc ctctggacct tcaacgactt caacacgccg
     6181 ttcgtcctct tcggcaaggc ggcaccggcg tcggcggacc tgatctccat ccacatctac
     6241 cagtcgtcct tccagacctg gaacttcggc acgggctccg ccatgtcggt cctgctgctg
     6301 ctgttcctgc tcgtcgtgac cggcctctac ctcctgttca cgtcccgagg aaagcaggcc
     6361 accgatgcct aggaccgcac agcgcaaggc ccccccttcc ccgatggcac ccccgcagtc
     6421 gttcctgtgg gcgcggcgga tcttcctgac actgctcacc gtcttcgtgg tcctgccggt
     6481 gttcgtcatg atcaccagct ccctcaaacc gctggaagac gtcaccggga agttccagtg
     6541 gatcccctcg ggtctgacca tcagtcccta cttcgacatc tgggacacgg tccccctcgc
     6601 cgactacttc atgaactccc tgatcgtcgc cggggcggcg accgtctgtt ccgtggtgat
     6661 cgcggtgttc gcggcctacg ccgtcagccg ctacaacttc cgcggcaagc gcgtgttcac
     6721 ggtgaccgtc ctctcgacgc agatgttccc cggcatcctc ttcctcctgc cgctgttcct
     6781 catctacgtg aacatcggca acgccaccgg catcgcgctg ttcgggtcgc gggccggcct
     6841 catcatcacg tacctcacct tctccctccc cttctccatc tggatgctga tcgggtactt
     6901 cgactcggtg cccagggatc tggacgaggc ggccaaggtg gacggctgcg ggccgctcgg
     6961 cgcgctgttc cgggtcatcg tcccggcggc gatccccggc atcgtcgccg tcgccgtcta
     7021 cgcgttcatg acggcctggg gcgaagtgct cttcgcctcc gtcatgacca acgacaccac
     7081 ccgcaccctc gccgtcggcc tgcagggcta ctccacgcag aacgacgtgt actggaacca
     7141 ggtcatggcc gcctccctcg tggtgagcct gcccgtcgtc gccgggttcc tgctcctcca
     7201 gcgctacctc gtcgccggcc tcaccgccgg cgccgtcaag tagccgcact caccgaccgt
     7261 tcgcccaccc ctgcctgctc gaattctgcg aggtaccttg tgtccgaacc gatagatctc
     7321 gccgccttcc cccgtgactt cgtctggggc acggccacgg ccgcgtacca gatagaaggc
     7381 ggcgtcgccg aggacgggcg atcgccttcg atctgggaca ccttctccca caccccggga
     7441 aaggtcgcca acggtgacca cggcgacgag gcctgcgacc actaccaccg gtggccggag
     7501 gacgtcgccc tgatgaagcg gctgggcgtc gactcgtatc gcatgtcgac ggcatggccc
     7561 cgcgtcgtgc cgggcgggga cgggccggtc aacgccccgg ggctcgactt ctacgaccgg
     7621 ctggtggacg gcctcctgga cgcgggcgtc acccccaaca tcaccctcta ccactgggac
     7681 ctgccccagg cacttcagga ccggggcggg tggacggtgc gtgacacggc cgaacacctc
     7741 gccgcgtacg cggccgtcgt ggccgaacgg ctgggggacc gggtcacccg gtgggccacc
     7801 ctgaacgaac cactgtgctc aggatggatc gggcacctgg aaggccggat ggcccccggc
     7861 ctgaccgatc tgtccgcagc ggtccgggcc tcctaccacc tgctcctggg ccacggtctg
     7921 gccacccagg cgatccgggc cgcctccccc ggggcgcagg tcggactcgt gaccaaccac
     7981 tccacggtgg aggccgcgtc ctcgaggccc gaggacctcg cggcagccgt ccgcatggac
     8041 ggtcacacca accgctggtg gctggacccc gtgtacggcc gcggcttccc cacggacatg
     8101 cgggagctct acggagtcga actgcccgag tgcgcggggg acctggagac catggccgcc
     8161 cccctggact ggcacggtct caactactac ttcccggtca ccgtcgccga cgaccccgaa
     8221 ggtcccgtcc cgcacgccag ggaggtccgg ctgccagacg tgccgcggac cggaatggac
     8281 tggcagatcg atgccggcgg tctcgaagcg ctgctcatgc gcctgaccga cgactacggc
     8341 gtaggccgcc tctacgtcac cgagaacggc tccgccttcc ccgacaccgt cggccccgac
     8401 ggtgcggtgg acgacccgga acggacccgc tacctggagc agcacctggc agcgtgcgcc
     8461 cgggccgtcc gcaagggtgc gcccgtggcc gggtactacg cctggtcgct gctggacaac
     8521 ttcgagtggg cctacggcta cgacaagcgc ttcggcctcg tccatgtcga ctacccgacg
     8581 cagacacgca ccatcaagag cagtggccac cggtacgcgg acgtcatccg tacgcaccgc
     8641 ggcactcgtg cctgacggcg cttcgtagca cagtgtgtct cctgccgggg ctgccatgga
     8701 tccggtccca catcgcacag tgatcaccac cgacgggggt ggatcgcggc ctggggcccg
     8761 aagcggagcc ggctggtcag cggtcagcgg gcccggcgtg agaagcgggg ccgatcgtgg
     8821 ccgtccggct cgatgcagcg ggactggacg tgctcatagg ccctggtggt ctgcacgtcg
     8881 gcgaccctct gcgttcggtg aggcggtcga aggcgtacac gccgtcgacg tcggggacgg
     8941 cgatgcgcag gaggaagtca tgtgtgccgg aggtgacgaa cagaccgagc acctccggca
     9001 ggcgtgcggc ccgttcccgg aacccctcga tgacggggcg ggccgggggc cggatgcgca
     9061 ccggggtgag tgcctcgacg ggccggccgg cccgtcgagg cccagggagg aaggggacgt
     9121 tccacctggc cgggccgccg acgccaccgt ctgcgccgcg gccccgtagc ggcgaagcgc
     9181 tcagaacggc atgcggcccc gggcccgtcg tccggccgag ccgctgttgc ccacggcctt
     9241 ggagctgctg cggaacggct tgctgaagat tcggcccagg acacccggag ccttgccgcc
     9301 ggcgcgtgat ccggccccga gggttcgctg ggtgccacgt tcggggtggc gggacaagcg
     9361 cggtacgagg aacgcgagga cggccagtac gacacagacg gcgacgatgc cgacaatcat
     9421 catgaggagc tccctgggtt ggtgtgtcct gccgtctgcc ccggcggacc accggtatgc
     9481 actgccactc cggagggtgc tgccgtacgg ggcgagcacc ggccgctgcg ggaggcagac
     9541 cctcgcagtc ctcttggtcg acccgtgtcg aggagcgcgt ccgcccgagg agtctggagt
     9601 ccgtgaggcc gatcagggcg ccgaggggct cagacgtgca gggccggcct gtaggagagc
     9661 tcttggatgt ggccgtcgag cgtccggtgc ccgatcagct cgaggagagc tgcgctccca
     9721 cggcagcctg tcgatgaacc gggcgttgac ggccgccgga ccggtcgacc gggtccaggt
     9781 gactctcttc cccgtgatca caggtcggac cgggctggac ccggtcttcc ggggtgcggc
     9841 agcgtgatcg gcgacaggcc cggatccatt cccgaggcag cgcgtgttgc gcgacccggc
     9901 ctcgggacgg ccggccgggt cctcgccgcg cccggggccc cgtacaccgt cggtctcctc
     9961 gccctcctga ccccaccgag cggggcaccc cgcctgccgg tcacaacctg cggtggagca
    10021 ggaacccgag cagcacgtcg atctcgcgcg ccgcgcgcgg ggcgaggggc acgctccgca
    10081 ggcaggcgcg ggccgcgtcg aggtggtggc ccgcctcggc cacggtggcg gtgcggccgc
    10141 cgcacgcttc cacgagtgcg gccgcacgga ccgcgccggc gtcgtcgagt ccgagcgggg
    10201 agtccagaag acctgccagc tccctggcac ggcggccgtc accggcgaga gcggccagaa
    10261 cggggtaggt cttcttccgc tgccgcaggt cgctgtgcac gggcttgccc gtcacggcag
    10321 ggtcacccca gatgccgagc aggtcgtcga tgacctgaaa ggccaccccg aggtggcgcc
    10381 cggcacggtc cagcgcggcg acggtgcggg caggagcccc gcccaggagg ccgcccagcg
    10441 ctgcggcgca gcccagcagg gtgccggtct tgagttccgc catggcacgg tattcgtcgg
    10501 gccagacggc ctcggggccc gtccacgggc gggccgcgaa gagaaggtcc tccgcctgac
    10561 cgtgtacgag gccgcccagc gtcccggaca gccgcccgac ggccgcggcc gtgtgcggtc
    10621 ccggtgtctc ggcgagcgtc tgcaccgcga gggcgaagag cgcgtccccg gcgagcacgg
    10681 cgggcccggt gccgtacgcc ttccacacgg tctgccgctg ccgccgggtc ccgtccccgt
    10741 ccatgatgtc gtcgtgcagc agcgagaagg tgtggatcag ctcgacggcc acggcgccgg
    10801 ccacggcgct ctccccgggc gcctccgcgg cctcggcgca caggacggcg agggcctgac
    10861 gcacgccctt gccctcgaac gacccgtcag ccggcgtacc gccgacctcg caccagccga
    10921 gggagtacgc ggccatctcg cccggccagg gatggagccg cccgacggcg gccgacaagg
    10981 acgggcgcac cagatcgcga cagcgggcga gtatgccggg cgcggtggcc gagggctcgg
    11041 acgacgcggc gtccggaggc gtgacgtccc cggcaggcgc ggccttccgg gcggatccgg
    11101 cgggcgcggc gtcgcgtacg gtgccggccg aagcggtcac gggggaggtc atcgcgtcac
    11161 cgcctcctcc gtgcggtggc cgacgccggg cagcgggccg acccccagct cctccgccgc
    11221 cttgtcgacc atgtcccggg cgtgcttcag gccgatgcgg tccagggtcc ggcggagccc
    11281 ggccagttcc acgaccgttt ccgccgggtt ccgtccgagc cgggccagcg acttggcgag
    11341 ccccagccgg gacagcgcgg tgccccgtgg ctcgttcatc tcctcgaatt ccgcgagcgc
    11401 ctgtgcgtag gtctcacggg cctgcgggta ctgccccgcg cggtagtgca cgttggcccg
    11461 catcttgtgg ttgtacgcca gcgcactgga caacttcatc tcgcggcaca cggattcggc
    11521 ctcggtgagc agcgccagcg cacgctccac gtcaccgtcg cgtacggaca cgacgtcggc
    11581 tatgccgcgc agcgcccagg cccggcctcg ccggtcatcg gctcggtgcg cggtctcggc
    11641 cgcctcctcg aagagggcga gtgccctgtc gtacgacccg gtgttccggt gcatctgggc
    11701 tatgccttcc agcgcccaga ccgtgtgccg ggcctctccg cgcctgcggg cttccgcgag
    11761 gagttgttcg tgcagctcgc cgacggcctg gtagtcgccc tggatgcgcc ccgtctccgc
    11821 gagaccggcg agcgagtagc cgcgtacgac cacgtcgccc ccgcgttcac ccatctcggc
    11881 agcgagcccg aggagccggt acgcgagtgc cagcgagccc cgttggcggg cgagcgtgcc
    11941 accgctccac aacgcccatg ccatggcccc gacgtcctcc gccgaacgtg ccgcacggta
    12001 actcgacttc cacgcggcgt cggcatcagc cacgcgcccc agccgcctgt acgcctccgc
    12061 cacagcgagc ccgcagcgtg ccatttcccg gtgctccccg gcacgttcgg cagcccgtag
    12121 ttcttcgacg cccttcgcca gcacctcgct gagggaggag ttcaccgaca acgagccgag
    12181 cgccccctgg tattcgggag cgaacgcctt gcccttcggc cgatcctgct gagtcacccg
    12241 tgccacctgc tcactgtctc gcctgtcttc ggaaccgttg ccccgacggc tgtcggccgc
    12301 ggtctctgat caagacggta tgagccggcg ggggttccac gaatccctct tcacgtcggt
    12361 cacgggtcat acgtgagggc cacaggagac acgtggacta gtcatcggga tggacgccgc
    12421 ggacggaggg ggtggccgct caccgtcgtc acatggccgc cgcgtaggtc ctgctcgcac
    12481 gggcaggacc gccggcggac gctgtgggcc acgcgcccgc ggtcctccgt gagagggagg
    12541 ccgaggaacc tcgtccggac ggtgtggcgg acgggcgcgt ccgtccgcgg gaaggatcag
    12601 aggcctgtgg gtgcggccgg gttcagtcgt cggcgacctg gacggctatc gcgtagtagg
    12661 tgccgtccgt ccccgcgatc aggctgtcga agaccggtgt gagcaggttg acggcgccgc
    12721 agtcggagtc gtggttggtc caccaggtcg cgtcggaccc gagcagcgac accacacgct
    12781 tcgccgtccg ggcggctacg gcgtggtcca tgagggcgtg ggacggccag acgatgtcga
    12841 cggaggcgac agacgtgagg agacctgccg cggtccccgc ctcgatgagc tccaaactgc
    12901 cttcgacggc cccggccgcc ggcggtaccg cgggagcgag gaagcgcttc cacgccgggt
    12961 cctcgaaaac ctgggtgagc aacgcgcgga tctgcgccgt cagttccgcc atgtccgggg
    13021 cggactccgc gtaccggccg gcccggacgt acacgcgccc ctctgtggac agcgcggcca
    13081 tgctccggcg cagctcgctc agcaggacgt cgtgggacct catgcagtca ttgtggcgac
    13141 tccccggaga ggcatcggca cggcgtccgg tacgggtgac gccacccggc cgcagatcga
    13201 gtcccggtac cggtccggca gtcgaggctc accgatctcg tggcggtcgg ttcggcggga
    13261 tggcggtcga gggcctgctc ggacggcacg tgcaggtggt agccgtgcgt cggactgcgg
    13321 tggtcggcgt gcggccgggg gcggcgccag ttccccggaa ccgcctagat ctggtccgtc
    13381 gggttgctgc gcagcttgcg ccgttcccag cggctggggt ggcggatgac cactcccgac
    13441 acgccgccgg agcccgtgag ccggatcagc ggagtacccg ggaggcggtc cggagtggtc
    13501 ctgtccgtca ggccgccgat gccggggtcc atgccgctgg tgtccgcggc ccaggcgtcg
    13561 gggatgacga cggtgacacc ggccgcctcc ccgtaggcct ccaccgcgat ctcgttgagg
    13621 cggcactgga cccggctgaa gtccagcttc acgccgcccc atcctccgtg agcgaccacg
    13681 cgccccggaa cctcccaacg cccgggacct cgggacgcgc cgttcattcc gcccttgagt
    13741 accagcggcg gccggttctc cgaggagttc aactgcggca ggtcggcagt caggacggcc
    13801 agctccgcgt aggtcttgga cgtcaacgcc tgctccagac gcgcatccag ctcgtcgaga
    13861 tcgatacggc cttcggctgc cgcgtcgcgc agccgctcca ccaccgcttc ccggtcgtca
    13921 tgagaggcgc ggagctcact cggggcagca gggcgcgggg agggctccgg aagctgagca
    13981 gtcatgtcca caggataagt gcccggcgga tcggggcgca cgggtaccgc gccatggggg
    14041 agttgtgccg cccgaggcgt caaccgggat cgaggtgggt aaggttgcga ccgtcaagtg
    14101 aagatagcct tacctaagtt ttaggagtat cggtgaccaa ccccttcgag gtcgagaacg
    14161 gcacctatct ggtgctcgtc aacgacgagg gacagcattc gctgtggccc gccttcgccg
    14221 aggtgcctgc cggctggacc gtggcacacc aggaggacac ccgccaggcc tgcctcgagt
    14281 acgtggagcg gaactggacc gacctgcggc ccaagagcct gatacggagc atggcggccg
    14341 gtcccgcctg agccgtccca cggagccgcc tacgtgacca tgccgcgggg tcgccggcgg
    14401 agccggggtg gcaggcgctg ccgccgcccc gggcgttccg ctcggcggcg tccgcaccga
    14461 cggtcacggc accccgccca cgtgcgcggg gtgccgtaac cgggggccgg ggaggcacgg
    14521 aaacgcccgg ccgcaccggg gtgcatcagc acgcgggcac ggcgatccgc acacgactgc
    14581 tttcgccgtc ggaaaggaac gaggccagtt cgctcccctg ctcggcgacg ctgtcgcggt
    14641 cgggccggga gaggccgcgc agcggggtca ccaccacggt gcccacgtcc acactccagg
    14701 tcgcggcgac ccggccgtcg accagtacga cgcgctcgcc ggcgaccgag agaccgcggt
    14761 gggcgtcgtc gatgatccgg ccgcggtcgt ggtagccgag gatggcgttg tcgaacgccg
    14821 ggaggaaccg cacaggtgcg ggcgttccgg ggtcggggcg tggtgcgccg gggaggtcga
    14881 gcagttcgcg gccgcgctcg tcccggaagg agacgagttc ctcgcgcagc gccttcaccg
    14941 ctgccgggag cccggccagg ccgcaccacg cgcgcaggtc cgccgatgcc gcaggcccga
    15001 aggcggccag atagcggcgt accaaggtct ggccgaccgg gtcggagggg tcgaggaccg
    15061 gcgggtcgat gctccggccc agccaggagg agagcaggac gttgcgcacc cccgcatcgg
    15121 tgcgccacag cccccggggc ggggtctgtg cgaccggtac cagggcggcg accaccatct
    15181 cgcccagggc ccggcgtcct ggcttcggcc agcgcacggt gagctcgcgt accaactcgg
    15241 cggccgagcg tggcttcccg tccgccagca ccgcccgtcc ggcctcggcg agttcgtcga
    15301 gatccgtccc gtcgaactcg cggcggtata cgccgagcac ccgctggcgc agcatggcgc
    15361 cgtggcgagc ccgccaggcg accgcgtcct cggcggtcac caggtggacg gtgcgccgca
    15421 tcaggtggac ccgtaccacg ctgcgccgga ccagcaggtc agacagggac gccggttcga
    15481 acgttcgcaa ccgcgaccag agtccgacgt aaggctcctg cggctcctgc gcctggaggc
    15541 cgcccaggtg gccgacggcg tcgagcacgg gcaggccggc gcgatcgagg agcaactgcc
    15601 gggcgagcgt ggcgcgattg agcgcccggc tgtcgagaac ggtcatcgtg tcaccacggg
    15661 ggcggggcgc cggaggtggg ccgcgttccc ggcccggccg gaatctcgcg tgttcacggc
    15721 ggctgtgttc ctttcggtcg cgtgcatgtc cagaaccaca gtcgcagggg aagcggacag
    15781 gggctgtccg cttctccggg ggatactgct gacatggcga ggacctcggc gcgactgctg
    15841 tttctgctct ccctgctcca ggcgcgtcgt gactggccgg gccaggtgct ggcggagcgg
    15901 ttggaggtga gcccgcgtac ggtgcgccgt gacgtcgacc gcctgcgtga actcggttac
    15961 cccgtagtgg ccgccaaggg gcccgacggg ggctaccgcc tcgacgccgg cgcggaactc
    16021 ccgccgctgc tgttcgacga cgaccaggcc gtcgcccttg cggtcgcgct ccggaccgcc
    16081 gccaccaccg gtgccggtat cgaggaagcg gcggcacgtg cgctgaacac cgtccggcag
    16141 gtcatgccgg cgcggctgcg ccaccgcgtc gacgccctcc acgtcaccgc cgtcggaccc
    16201 gcggagacac agcccggtcc gcaggcggac ccccgcgtcc tcgtcgcgct gagcgaggcc
    16261 gtccacgccc gtgaggtcct gcgcttcgac tacaccgtcg aaaattcgga ggccgggcac
    16321 agcgacgccg tgaagccgcc gcgccgtgcc gagcctcacc acctcgtcac ctggcggggg
    16381 cgctggtacc tcctggcctg ggacctcgac cgcgacgact ggcggacctt ccgcgccgac
    16441 cggatcgccc cgcgcacccc cagggggccc cgtttcaccc cgcgtgacgt gcccgggggt
    16501 gacgtcgccg agttcgtggc aggcagattc cagggatccg gcagcggcgg ggactggcct
    16561 tgccgcggag aggtcatcct tgacctgccg gctcccgtcg tgtcccgcta cagccgcgac
    16621 ggagtcgtcg aggcactcgg tccggaccgc tgccggctcc tcctgggggc gtggtcatgg
    16681 cccggactgg cggccacgat cggcaggttc gacgccgact tccaggtcgt cggaccggcc
    16741 gaactcaagg acgcctgcgc gaacctggca cgccgctacg ccgatgccgc gacccgcgaa
    16801 cccccaggga tatgaccggg ctccgcgggc cggtcccggc gctgcgcggg tgccttcgta
    16861 cggccggggc cggccacgga acgcacgagg cgtccgcccg ggaacccgga cggacgcctt
    16921 cgagccgcgg gaccgccggg cgcggaaagc cgggtcagga ctcctcggcg gcccgtgcct
    16981 tgggcgtggg accggcggcc acgggcaccg gctcgtcgcg ccgtgaccgg tgggacatcc
    17041 atgcggcgac cagggcgccc gagatgttgt gccacacgga gaacaccgcg gccggcagag
    17101 cggcaagcgg gctgaagtga gcagtcgcca gggaggcggc gagaccggag ttctgcatgc
    17161 cgacctcgaa ggccatggcg cggctggcag gccggccgag cccggagacc ttgcccgcgc
    17221 cgtaaccgag cgcgaggccg aggccgttgt gcagcacgac ggcgatcagc acgctcacag
    17281 cggccgactt gatcatactg gcgctgcccg ccacgacggc gcacacgatc gcggcgatgg
    17341 ccagcgacga cagccagggc atgaggccca gcacgcggtc gacgaacttg cccgcgacga
    17401 ggcgaaccac cagcccgccg aggatcggga gcagcaccgt cttgaggatg tcggtgatca
    17461 tcgagccggc gtcgacaggc aggtaggccc ccgccagcag cagtgtgagg ggcggcgtca
    17521 ccagcggggc gaccagggtg gagacggtgg cgacggagac cgacagcgcc acgtcaccgc
    17581 gggccaggaa ggtcaccacg ttcgacgccg tgccgctcgg cgcgcagccg accaggatga
    17641 gcccggccgc caactgggga ggcagctgga gcagatgagc gatggcccag ccgaggcccg
    17701 gcatgatcac gtagtgcgcg acgaggccga tcgccacggc ccacggacgc ttcaccacac
    17761 ccctgaagtc gagcggggtc atcgtcagcc ccatgcagaa catgacgatt cccagcaggt
    17821 aaggaaccga tcccgtccag ccgtcgaacg tgccgggggt gacgagaccg gctacgcccg
    17881 ccacgagtac gagcacgggg aacaccgtga cggcgcgcct cgccgctctg tcgtcggagg
    17941 ccggttgatc agggcttatc tgttcggttt gcacaggcgc gatggaacgc cgcaggtgta
    18001 cgcctccgca aacgcgtctc gctatacgga cgccatgtcc aggatgtgtc tgacctgaga
    18061 gtcctttccg gccgtggcta caggtgtatc ccacgcccct gccaacggct cctcagccgg
    18121 cggtcgtggc cggcgatgac gatcgctcca gggcccgcac ccatggcgtc ctcgagctcg
    18181 tcgcagagct gcggggacag gtggttcgtg ggctcgtcga ggagcagcaa ctcgggcgga
    18241 tgcgccacca gcagggccag cgcgagccgg cggcgctgac cgacggacag gcgtccgacc
    18301 tgcttgccga gatccgcctc ggccatcagg ccgagcgagc tcagcgggac ggcttccgcg
    18361 cgctcgtcgc cgagcgcatg tgcgtaggtg tcccggacga tgcggtccgg ccggtcgaag
    18421 acggtgtcct gggccagcag ccccaccgag agcccgcccc tgcgccggac ctcgccggtg
    18481 tccgccgtga ggtgcccggc gagcacggcc agaagcgtcg acttccccgc accgttgtca
    18541 cccgtcacga gcagacgctc ggtcgccgac acgtcgaggc ggtcgacggc gaggcggtcc
    18601 cggacccgta cgcctcgcag ggagacgagc gttccgtccc ccgacggtcc ggcgagcgcg
    18661 tcgcggcgga agcgcagtgg caggggcggc tgggcgaccc ggtgccgctc cagttcgtcg
    18721 agtctgcgtg cggcgttacg gacccgccgc gagacctggc tctgtacccg gcctgcccgg
    18781 acgccgtatc ccatcttctc gttgtcgcgt ggtccacggt ccggggcgac gcgacgcgcg
    18841 gtcgtgccgg ccgacaggcg cagggcttcc agctcctcct gctcctcggc gtagcgccgc
    18901 tcccagcgct cccgttcggc gcgcttctct gcctggtagg cggagtagtt gccgccgtag
    18961 cgcacaggtc cgtcgacggc cgggtcgagg tcgaccaggt ccgtgcacac ggcgtcgagg
    19021 aaggcccggt catggctcgc gaccacgacg gccccggaca ggccgcggac ctgctcctcc
    19081 aggaactcgg cagcacggtc gtcgaggtgg ttggtcggct cgtccagcag cagcgccgaa
    19141 ggcctgcgga ccagaaggga agccagggcc aggcgcccgc gctgcccgcc tgacagggag
    19201 tcgagcgccc ggtcccggcg gatcccgccg aggccgaggc cctcgagcac gatcgtggcg
    19261 cggcggtcgg cgtcccaggc ctcctgttcc cgggcgcgct cgagccgtcg gccgtaggct
    19321 tcgagcagcc cggcgtagtc gggggagtcc tcctgtgcgc aggcgagacg gccggagagg
    19381 tgttcgagcg cggcgagctc gtcgcggacc tctcgcaggg cctcgtccag cacgtcggcg
    19441 atcgtggccg ccgtgtcgaa cggcatctcc tggtgcagga agcccaggtc ggcagggcgg
    19501 gtgatgatgc ccgcgtcggg ttcgtcggcg ccggcgagca gacggagcaa tgtcgactta
    19561 ccgacgccgt tctctccgat cagcccgatg cggtggccgg gggacgcggt gagggagaac
    19621 ccgtcgacca cccgcccggt gccgaaggag cggacgacgt cgcgtgcgag cagggctgca
    19681 gaggggatgt cggacataag ggtgacctcg tgtggcgtgc gggcagacgg acttctgccc
    19741 cgggtgggca cgggaaaggg gaacgacggg gtgccacgcg gcaacggtgc tgtcgcgcac
    19801 cggccgacgg gcggtcacat ccgggtgtca cccggagatg tcgtcgtctc ccaccatgtc
    19861 ctgtctcctc gccgagagat cgttgtcccg agggacccta gcagccgacg gccccccggc
    19921 cctgaggttt tgtcatcctt gcgcccggtc cgtgggcgcc gcccggaacg ggcgatgtgc
    19981 ggcgccgaag cggacgcgca ggcccggtgg tgtggctgcc gtcgtcaccg caggcggtgg
    20041 gggagcgggc cgccacgagc gcgggggcga tgacgccgaa ggtcctcgaa gggctgcgag
    20101 tcgtcctgcg gtcaaggtgc cgactgctcc gtacgagcgc ttgtgtgggt catgcgtgca
    20161 atgtctccgt ggcggatgcg caccgggcgg aagatcatcg ctccgctgcc accggaggct
    20221 cgtgcgcgtc aggagccctg ctccgcacgc ccgctggcgt aggtcccggg gatgcggagt
    20281 accacgcttg cgggcagcgt gggggagtgc cgcagttgct gagaacccag tggatccccg
    20341 taggcctcat cgtgctggcc gtggcggtcg acctggtcac accgcacgat gtgacgtccg
    20401 cgccgctcct catggcggca cccgtcgccg ccgcgccgct cttcggcgtg cgggggatca
    20461 tcggcatcgg cctcacggcg atggtcgtcc acgcgtttct cgcgcggctc gacgggacct
    20521 tcggctggcg cgcgggcgtg gccaaccaga tcaccctggc ggctgtcacc gcgctcgccg
    20581 tgctgatcca ccgcacgctg cgcagacagg acgcccgcgc ccggcgcgcc cagcacgtag
    20641 cggccgtcgc ccagcgggcc gtgctgccca ggcccccgtc acggctcggt gacctgcaca
    20701 tcgacgcgcg gtacgtaccg gccgagagcg aagccctgat cggcggagac ctgtacgtgg
    20761 tgcagagcac cccgtacgga atccgggtga tggtcggcga cgtacggggg aagggcctgg
    20821 gggcggtcag cgccgtcagc gcggacctcg gcgccttccg gtacgcggcg gacgagtccg
    20881 aggaccttcc gcaactggtg acccggctgg agagggctct cctgcgcgag ggcggccggc
    20941 gcggcggaca gcagcagcag gagggcttca cgacggctct catcgcggag ttctccccgg
    21001 acctggagac cgtacgcctg gtcaaccgcg ggcatccgcc gcccgtactc ctcgacgcgc
    21061 agggcggcgc cacactgctc gaggcgtccg aggaggcgcc cccgctgggc atgagcgacc
    21121 tcggagcgtg gtccgcgccg ctcgacagct tc
//
