LOCUS       NZ_CAKMXI010000002     25266 bp    DNA     linear   CON 03-JUN-2024
DEFINITION  Streptomyces atroolivaceus strain TUE2108, whole genome shotgun
            sequence.
ACCESSION   NZ_CAKMXI010000002
VERSION     NZ_CAKMXI010000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces atroolivaceus
  ORGANISM  Streptomyces atroolivaceus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 793806)
  AUTHORS   Wibberg,D.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-FEB-2022) CEBITEC, Genome Research of Industrial
            Microorganisms (GRIM), Universitaetsstrasse 27, 33615, NRW, Germany
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_928722305.1-RS_2024_06_03
            Annotation Date                   :: 06/03/2024 04:23:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,057
            CDSs (total)                      :: 6,983
            Genes (coding)                    :: 6,683
            CDSs (with protein)               :: 6,683
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 2 (5S, 16S)
            complete rRNAs                    :: 1, 1 (5S, 16S)
            partial rRNAs                     :: 1 (16S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 300
            CDSs (without protein)            :: 300
            Pseudo Genes (ambiguous residues) :: 0 of 300
            Pseudo Genes (frameshifted)       :: 123 of 300
            Pseudo Genes (incomplete)         :: 254 of 300
            Pseudo Genes (internal stop)      :: 20 of 300
            Pseudo Genes (multiple problems)  :: 87 of 300
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:59:12
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 115787
            Orig. end                         :: 141053
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CAKMXI010000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25266
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="2"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25266
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25266
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15266](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15266
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    428..444
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.27"
                     /tool="antismash"
     misc_feature    complement(485..502)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.34"
                     /tool="antismash"
     gene            611..1039
                     /locus_tag="NBY68_RS04400"
     CDS             611..1039
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014143550.1"
                     /locus_tag="NBY68_RS04400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_250287661.1"
                     /transl_table=11
                     /translation="MTTERQFAELLDRLFRDMHPKGRGPYTYAEVSAGIRESTGTSISA
                     SAIQQLRTGSNRNPKLETIRALATFFGVPPAYFFDAKESEQIEAELALLTTMRDADVRA
                     VALRAAGLSTETLSTISGFIERARALEGLHDNPEKPSA"
     gene            1240..1767
                     /locus_tag="NBY68_RS04405"
     CDS             1240..1767
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NBY68_RS04405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_250287662.1"
                     /transl_table=11
                     /translation="MNLRSHFGRVGSSAAKSPKHKGLLAATEIPDPFDVETFCEMLSAQ
                     RGRPVYLHSTPGITSSGVPCGAWIATERADHIFHEESTSPIHRTHIVLHEISHMLLEHT
                     SLQVERMAHLFKRVDSSAVKSVLGRASYNTEDERAAEQLADLLARKANLFSPNETRSDP
                     VLQRLDDALSDS"
     gene            1772..2944
                     /locus_tag="NBY68_RS04410"
     CDS             1772..2944
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF042915.1"
                     /locus_tag="NBY68_RS04410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MAB_1171c family putative transporter"
                     /protein_id="WP_250287663.1"
                     /transl_table=11
                     /translation="MASLIPAALLWIVTVWRAPAAWRVPAKRALWVAFFALSIAMTIRP
                     DGVSSALDSRLGIHNVTTLCKHLAGITAAYAVLTFVYDVAQEQAASLRGSRPRIVVPLT
                     AGVGLTLLFLAAPQPREATDLLTDFADDWRIAVYGVIWSSYLGTALVSATQLCWRWGRL
                     PGAGLLGRGLRITGMGTALGIVYAGHRVLALTLRYFGLTPLSPRTDENVSSALLFGALI
                     FILAGSTLPVVRRLHQWGRAHLALTRLYPLWLELTAAVPSVRLDPPRSRRADALHFRHT
                     RRRLYRRGIEIRDAILDLGDHASPTLRSEAARYVAEKGLMGAQAEIYAEACWIARAKEA
                     RENGDARVGEHTAPASGGKDLRSEVEALRHLATAYESALVREFSSARSSG"
     gene            2941..3525
                     /locus_tag="NBY68_RS04415"
     CDS             2941..3525
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010262855.1"
                     /locus_tag="NBY68_RS04415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphatase PAP2 family protein"
                     /protein_id="WP_250287664.1"
                     /transl_table=11
                     /translation="MKLTSTRLARIVTDALAPAYLVIAILLIIGWHSTRSPEGLAWGLL
                     AALFCGGIPFAIILFGVKRGSWTDKHVKVRSQRAVPLTATMVSVLVGILIQVVFDAPRE
                     LFALVIAMLVGLAATMVVTVWWKVSVHTAVAGGVATILSLVFGPPLAALALVVAAIGWS
                     RVQLRDHTVAQTIVGALLGGAAAAVTFGLLR"
     gene            complement(3651..4538)
                     /locus_tag="NBY68_RS04420"
     CDS             complement(3651..4538)
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031333.1"
                     /locus_tag="NBY68_RS04420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_250287665.1"
                     /sec_met_domain="APH (E-value: 5.5e-21, bitscore: 71.1,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSAAAAPARNVLEQACSAVGLDCSGAEPLRLAENQIWRLPGRRV
                     IVRISRAGQSAAAAREVRVARWLAQENVAAVRLVDVEQPIEAGGRPVTFWVELPPQEHG
                     SVQDVAQLLSQLHSLPMPDIELGHLDPFVRVGERLQAATTIRDDDREWLHGLHRDLAAA
                     WAERPAGLPDRAVHGDAWPGNFVRTVDGVLMMDLERFSVGPPEWDLVSTAVRAKTTGAV
                     TAREYDQFCAAYGHDVTAWEGYPILARARELRMATYAAQHAASNEEWISQAQYRIDCLR
                     GRSGPRPWTWTGIL"
     gene            complement(4535..5548)
                     /locus_tag="NBY68_RS04425"
     CDS             complement(4535..5548)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676480.1"
                     /locus_tag="NBY68_RS04425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_348538807.1"
                     /transl_table=11
                     /translation="MIRRSFLQIGGLAAIAPLDLTEIFAPAELTLPANVNPGHVDQVLA
                     AATAISGMDNELGGGGMVRDVASRAMQWSAGLLQAQCSEHLRAELFASVSRLGIVVGAS
                     AFDAYHHDDATQTFRFAADCAEESGDWHLRAKTYSFLARQAVWIGAPDDGLTYAEKGLV
                     RADRLTATEQAMLHTARARAFGKMGNVRDTMAAVGAADEAFARARPAEDSPWMAYYDEA
                     QHNGDTAHALFDLAILAGQDPGRAARRFGTAVKGHTDAYKRSRAISRTKLASLIMAKGD
                     PRQAAALGHEALDEVGRLTSRRAADDLRQLGRFASKHRTVQEASGLRERIAATVSV"
     gene            complement(<5777..5938)
                     /locus_tag="NBY68_RS35485"
                     /pseudo=""
     CDS             complement(<5777..5938)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024949.4"
                     /locus_tag="NBY68_RS35485"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPQPMKQLDPGASPQEWFGNELRNLRLEHGLSAKALGRLVQVSDD
                     MILSIEKGK"
     misc_feature    complement(5822..5824)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6180..6575
                     /locus_tag="NBY68_RS04430"
     CDS             6180..6575
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024970.4"
                     /locus_tag="NBY68_RS04430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding protein"
                     /protein_id="WP_250287667.1"
                     /transl_table=11
                     /translation="MSFEVRAEDLGTVRGIVAAHLCWWRIDDSTAHRMLTVVNELITNV
                     LQHTAADTDGCQMASLLLQKVPDGVTAVVRDQDSCLPVYASPDLLAEEGRGLLLLRALA
                     DDTSVSVTPGGKDVWVFIGSPETPERF"
     gene            6615..7067
                     /locus_tag="NBY68_RS04435"
     CDS             6615..7067
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012380189.1"
                     /locus_tag="NBY68_RS04435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6415 family natural product biosynthesis
                     protein"
                     /protein_id="WP_250287668.1"
                     /transl_table=11
                     /translation="MSLTALVPENDVVPPPADEPSITQWTPPLDVEGLRSVLERIKDWK
                     PLDVGEVFDDLDTAIGNQPPPVTTAGVLVDRLRSHLKQLSDIALADEQFPPTRVMVQLV
                     ERGLPLRGERTPTAHRQVVGLARRLAFVTSDLVEELIEARYITEAE"
     gene            7403..7603
                     /locus_tag="NBY68_RS04440"
     CDS             7403..7603
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008746445.1"
                     /locus_tag="NBY68_RS04440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5999 family protein"
                     /protein_id="WP_250287669.1"
                     /transl_table=11
                     /translation="MCAHNPPCPVAEAPDREAARPVTHRPEQGWSLLCNGVLLFEDTGE
                     ILPDGRVIAPRRSLDRARAAA"
     gene            7600..8265
                     /locus_tag="NBY68_RS04445"
     CDS             7600..8265
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014143560.1"
                     /locus_tag="NBY68_RS04445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_250287670.1"
                     /transl_table=11
                     /translation="MKRSSAAPRLVPYITSREGEYGALESELTLRMNVFGAVRLAYHDE
                     TPADRGPRGELWARCSQSLNTAGRPTGKPQWRLVNPARQRAAMQQLRCQISFCPAETAR
                     GYVFLTGAAEDPSHRPGEPVRTAQPPVCLEHVRPAVELCPHLRKGHVALLAGATSVWGV
                     IGSRYRLTATGLEPLPAEDDDAPVAYGHSQLGWFLASQLVRELHDYEVVNLDDLVPAA"
     misc_feature    7831..7833
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            8413..9648
                     /gene="fxlM"
                     /locus_tag="NBY68_RS04450"
     CDS             8413..9648
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018490583.1"
                     /locus_tag="NBY68_RS04450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_250287671.1"
                     /sec_met_domain="PCMT (E-value: 7.9e-37, bitscore: 122.6,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNTTVEPNEATRLRNMVVDELCADGNISSPEIEAVMRKVPRHSF
                     TPGTPLDKAYDRYAAVITKTDEHGVQLSSVSAPQIQAMMLEQAQVKPGMRVLEIGSGGL
                     NAAYLAELVGEDGEVVTVDIDPVVTDRARQLLNEHGYGRVHVVTADAAEPIPDLSEVDV
                     VMVTAGAWDISPAWTAQLKQGGRLVVPLRMRGLTRSVAFIQVEGEHGAYLESESARICG
                     FVPMQGSTAHREELLLVNGTPEIGLKFDDGLPADPHRLDNAVTFPRHELWTGVTVRIQE
                     LIDTLQMAMAISLPGFCTMAVDENSDTGLVDPVNKRFALAAVEDDTFAYLVTRRTEDNK
                     HLEYGVHALGPHAERFADKIADVLRDWEANRRGGPSPVIRVYPASTPDDQIPADRVIDK
                     VHSRISLSWPPA"
     gene            9700..9906
                     /gene="fxlA"
                     /locus_tag="NBY68_RS04455"
     CDS             9700..9906
                     /codon_start=1
                     /gene="fxlA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012380187.1"
                     /locus_tag="NBY68_RS04455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_250287672.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 2.5e-15, bitscore:
                     51.7, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSATLAPPPVAPAPLAGLDDDDFAPLDVKVVIAEHSYGHLMCST
                     GDGCGTTCATGASACGSFTEDPA"
     gene            10001..13066
                     /locus_tag="NBY68_RS04460"
     CDS             10001..13066
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008746441.1"
                     /locus_tag="NBY68_RS04460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_250287673.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.1e-200,
                     bitscore: 663.5, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 8.1e-17,
                     bitscore: 57.3, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.2e-13, bitscore:
                     45.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASRAAAGYQWQGVAMLRATTSPGPADIPRTLDLDNVAVTRGWLN
                     RIWQREDFRSALELATPVLSDAIEAVVRGRQTEPRHVRRTALSTVSYLLRWQHRPTPLG
                     LFAGIAPVSVGPRASARWREKHRTMIRPDAEWVTDMVLRLQRTPALLKRLPLVANNAAR
                     ARGDRLVASGPPSDGHAVLLAPVEISVRNAWPVAAAMDAARTPIPYGDLHGHLRDRFPQ
                     ATPEKIDALLTSLVEQQFLITSLWAPMTTADAFQHLCRELDRHQADDVPDVRDLVHALY
                     ALRDELSAHQPTLSDTSVSAVAARMSALTTVTPTPLLIDTALDCETQVPQSVIAEAQAA
                     VSALYRTTPQPYGYQHWRDYHRRFRARYGVGAMVPVMDLVADSGLGLPAGYVGSERGAA
                     LKVRTDRDELLLALVQQVLLDGDRELRLTDDIVDALEKAAGKDERLFVPRVEAAFEVHS
                     PSTRALSSGTFDILLTAVPRPGSSMAGRFAHVLPPEHQDALAATYHGAPDALTAQLVFP
                     PRRHRNENVTRTPRLLPHVIELSGHQETDETTIPLADIAVTADPRSFHLVQLSTGRRID
                     VRVLHALEGGTQTPPLARFLAEVANGRYAAYKPFDFGAGSRLPFLPRVRYRRTILTQAR
                     WLLMADDLPGRKAATEEWENAFTAWRDRLRVPMQVAIIEYDQRLPLDLSHPIHLRTLRA
                     HLDNARRLELREVPDADAHGWIGRAHEIWLSLGRLQPDTADVPRPRPAAPPTPGRHLPG
                     AGDVLLAQLHAHPRRYDEILSRHLPSLLAAFGDTPPVWWFTRHREMARPDADQHLDLTL
                     HLPPGAYGTAAQHIRTWADSLHRLGLASGLVLTPYQPQTGRFGGAAAMDAAHQVFAADS
                     AAALAQIQLTERTDAVAPQALAAASALHLVTPLAPNNAAAEEWLVRKLPQSTGRLNRAL
                     RTQVLELAVPNGASALAALPGGPAVAEAWRARAAAVDTYRNALTGQRDPLGVARSLLHQ
                     HHVRALGVDPRTEETTIRLVRTAALQHRMAAR"
     misc_feature    10460..10462
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        10469..10744
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_NBY68_RS04460_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="3.00E-18"
                     /identifier="RREFam001.1"
                     /label="NBY68_RS04460"
                     /locus_tag="NBY68_RS04460"
                     /protein_end="248"
                     /protein_start="156"
                     /score="57.3"
                     /tool="antismash"
                     /translation="VANNAARARGDRLVASGPPSDGHAVLLAPVEISVRNAWPVAAAMD
                     AARTPIPYGDLHGHLRDRFPQATPEKIDALLTSLVEQQFLITSLWAP"
     gene            13063..14295
                     /locus_tag="NBY68_RS04465"
     CDS             13063..14295
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008746440.1"
                     /locus_tag="NBY68_RS04465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_250287674.1"
                     /sec_met_domain="LANC_like (E-value: 3.5e-38, bitscore:
                     126.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPTVTTAAILEQYAAHLAQPAPPPPGEPWSVQSLADGAAGISL
                     LHIEMASRHGGSWRTAHRWITAAATGHISAADTAGLFLGAPALGFVLTTVPPCFQHLYE
                     PARQTLHQHIIDLSHRRVDAALARIRKGDLPTFAEYDLFYGLTGIGAYLLRTDPEGLPL
                     ERVLEYLVALTRPLAPEGRGLPGWWVRHDPARGESPHFPGGHGNFGAAHGITGPLLLLA
                     QAMRRGITVSGHREAIWSICEHLDAWCQLSPSGPWWPEHISRRDLDLGRPHHDAPTRPS
                     WCYGTTGIARAGQLAGLALRAPDVQAFYEDALYRALTDPEQLAHVADSGLCHGWAGIYQ
                     TAIRAAADALDHRLQTLPKRLGETLVAQAQPGGHPTTGLINGDAGTALALTTYASQQAP
                     ITGWDSCLLIN"
     gene            14277..15266
                     /locus_tag="NBY68_RS04470"
     CDS             14277..15266
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003961919.1"
                     /locus_tag="NBY68_RS04470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_250287675.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4e-34, bitscore:
                     114.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPDQLTQAESPLIQNAVLAVLTGLPIADAAHQYRMDTVALSSAV
                     KVYDQAGREALDRRSASTDWWQAYLHFTDWANADTTFTTHVLPVLRDAEAAGAIDGWWY
                     TRKHPCWRLRLRVRHTIGPKLTVGDDLDRLVADGHLQRWWPGFYEPETAAFGGAAGMTA
                     AHALFITDSREAQQLRQRGNLAVGPRELSVLLCTLMMRAAKLEWYEQGDVWHRVITEEH
                     RSAINDVPTTSLDARAREIRPLLFADTNALLRPGGLLEPVAEWATAFRDAGQALGHAVQ
                     DGTLDRGLRQVLSYHVIFHWNRLGLSMRGQSILAWAARAAILHGENGA"
     misc_feature    14808..14810
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            15586..16494
                     /locus_tag="NBY68_RS04475"
     CDS             15586..16494
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NBY68_RS04475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_250287676.1"
                     /transl_table=11
                     /translation="MVTSSSGFADWVTSDVESITVNGRETSTSEAASYLASVKVGVQTV
                     AVFNGPLERTFEFDFCLAEEEDLCLVDHALEKLISSRELSRSAIDTFIMRAGRGVTARR
                     YREGLATYLYGVLAREAVEDPGRVDASGAPLYEQRYNSAVSLLSTFDRPAAEAICGLVA
                     LHYNQFELAVRKTNSHRISDVAARFRSLLTGGTSVTTSLADRSHGSFDQALSDSVTEDL
                     LDVGAAALDGTQSPVVTQLLPSLGELRPQDQFKVRLIAAEALLAAGDIDGASRHGEAIR
                     HSNETGAWYAGFRIRLQEVGR"
     gene            16491..17717
                     /locus_tag="NBY68_RS04480"
     CDS             16491..17717
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NBY68_RS04480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_250287677.1"
                     /transl_table=11
                     /translation="MSNETIPEPGAEPGPDDPASANAAGDGEASAAPTDSAPTASVAEA
                     GPHRATSKTKTKPVITSIDDLLTFAYESNARLLDLPKEALKKLAITDEGLVSQSVLIGS
                     KAPTDPTLSTPFKLLQYAARQGVPLKRAESGDLAPALNRLFDLAVVALGHSPVFRVWVN
                     QLVDPCKGPQLSTEHLRSMAREVCADDLGLSPDQFKTADSERLVKNAIACYSLLRVLQR
                     EWTLDQFIDASYGSVWRYEAPKAAGLERAASQVGASSDLDVLGIVGENYRARIARLDRQ
                     VTQLEHEADAARNRETRLRSELSTVEEREQSAMARADSFSADVVRLQKELAAERDNRVV
                     DKSHMTDDYETLRTRIIRRLGGEIDLLTDGLHALRNGAPNVAEEFLDRSLLALTREVEQ
                     LKDASGGFA"
     gene            17714..19489
                     /locus_tag="NBY68_RS04485"
     CDS             17714..19489
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0140662 - ATP-dependent protein folding
                     chaperone [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012242.4"
                     /locus_tag="NBY68_RS04485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Hsp70 family protein"
                     /protein_id="WP_250287678.1"
                     /transl_table=11
                     /translation="MIVGFDFGTTNSLVSVVVGDRVIDVMDVETGRPHPSIVRYEGEQV
                     VVGREAKDALGAAGIGVHGNTVKSPKFLLGEEVIAVGGVDRSPVDIVTDVVRHVRSESL
                     RSPQRKVLGGLDSAVVTIPVTMNGHRRAALREAFAGAGMRIAQFVHEPLAALYGFIRGA
                     NDPEEMARRLARRNVLVVDWGGGTLDLTLCRVDEEQVRQLRNGGSAQVGGDEFDKVIRD
                     EVVKRVRARGSATDQDLAIPEAELRLLQDAERNKIELSADRVDVTFYRPSYFQSGATLQ
                     YQLTRQELEEITRPLVTAGIDEIESLLGSLSMAPGQVSLVVVVGGMAAMPAIRSRLYEM
                     FGPDRVEVPTNSATLISQGAAWIAHDRQRLRLAKPVELELARGSLMPLLAAGTEMPLGG
                     EVKHETLHLYCADPTDGKAKFPIATPTALSSHPQASERRTSLGMITIGVDEAAPPLHER
                     LELKVALDDDLVLSVEASSSQKRDRVTASYYDLEFGLGLPASAMPGGGAADPKAPEESI
                     VMPQAGLVVRANVARDKDQASVPGDVLYRHNSGAFARHLRDGATEAQLLEHLYYQPCSV
                     CKRQWGHPECRCGTA"
     gene            19491..20828
                     /locus_tag="NBY68_RS04490"
     CDS             19491..20828
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NBY68_RS04490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_250287679.1"
                     /transl_table=11
                     /translation="MASAKALVRVLDHGTEVESGVRRPIRLTPDGYAGVAYAGSVYPLR
                     QGDLIDLGGSSWELADCDRFLFAGADVPYAPAVGEPLERASGFDVEWHLETNQYGHYVV
                     FNASERVASSLVSALEGADLSVQRWDVSHRPAADGNFYDWFARLRFKGSQAEALALVGA
                     VVAPPSSLAPTVPVADPTTARLADAEARIEELLNQLYVATRKGEAAERELAQLRHDLAN
                     AEASEHRYRESVALAERHHADLHEQLSVLRQGLGGLADTAELVKSLADAEELRELALAD
                     NSLLLERVRAADSEVAESGARAGDLAVQVDALLGRVSELEALETERLRAATAQRPRRGG
                     VIAFLPQAFSRLEFVLDAVDVIANLESPASTMRALAEIDSGRLAGKDLEGVSGWFEVTK
                     LATGITGSERLGRIYYKPDGPRILVSVHIKQDGKQQRRHIERLRAF"
     gene            21150..>21302
                     /locus_tag="NBY68_RS04495"
                     /pseudo=""
     CDS             21150..>21302
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013068.4"
                     /locus_tag="NBY68_RS04495"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPHRASTPRPAQAGDLDLAIPKLRTGSLFPSLLERRRRIDQALYT
                     MIMENI"
     gene            21695..22138
                     /locus_tag="NBY68_RS04505"
     CDS             21695..22138
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="NBY68_RS04505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="transposase"
                     /protein_id="WP_250288163.1"
                     /transl_table=11
                     /translation="MLGRQFPKVKAMLLAAETDLTAFAERIWKKTGDQAPRRRRPDLPH
                     PNALERLNTAVLIEMYDEWIAFPHSCLPNGGTDSVYPTTEDPRRGYTATRTGLTMHDLG
                     TAELEGFLREHCLVRSTLGRQRLKFAPKAHRPDRERHFGDFLE"
     misc_feature    complement(22193..22207)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 25.37"
                     /tool="antismash"
     gene            22347..22964
                     /locus_tag="NBY68_RS04510"
     CDS             22347..22964
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014154300.1"
                     /locus_tag="NBY68_RS04510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6542 domain-containing protein"
                     /protein_id="WP_250287680.1"
                     /transl_table=11
                     /translation="MEQHRTRTPQRRQPPQGRPAQPGGLGEVTAPAAYPVTVAVAPVTG
                     PAPGSRPGGVPPVVMALRRFPNPRLTGIGAGLFAALAMFLLACLDRLLLDGSELVYGLL
                     FLPVSALTALWVRPADLVTAPIIVPIAFAVGVIPVAGGTGGFGGQAMAVVTALAVHAGW
                     LYGGTLIAGLIATVRKVRQMRERQRHLLRADRADRAARRPRA"
     misc_feature    complement(22393..22407)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 23.72"
                     /tool="antismash"
     gene            complement(22968..23705)
                     /gene="ppgK"
                     /locus_tag="NBY68_RS04515"
     CDS             complement(22968..23705)
                     /EC_number="2.7.1.63"
                     /GO_function="GO:0004340 - glucokinase activity [Evidence
                     IEA]"
                     /GO_function="GO:0047330 - polyphosphate-glucose
                     phosphotransferase activity [Evidence IEA]"
                     /codon_start=1
                     /gene="ppgK"
                     /gene_functions="other (smcogs) SMCOG1108: ROK family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019766075.1"
                     /locus_tag="NBY68_RS04515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyphosphate--glucose phosphotransferase"
                     /protein_id="WP_250287681.1"
                     /transl_table=11
                     /translation="MKIFGVDIGGSGIKGAPVDLDRGELAQERHKVLTPHPATPASVAD
                     GVAEVVGHFDWQGPVGITFPGVVTGGITRTAANVDKGWIDTDARALLSDRIGQPVTILN
                     DADAAGVAEMTFGAGRGRKGTVIMLTLGTGIGSAVFTGGQLVPNTELGHLELHGHDAEK
                     RASTKAKEDEELSWHHWAHRVQKYLVHVEMLFSPELFIIGGGVSRKAEKFLPLIEHVRA
                     EMVPAELQNNAGIVGAAMAAAGK"
     gene            complement(23813..24799)
                     /locus_tag="NBY68_RS04520"
     CDS             complement(23813..24799)
                     /EC_number="1.17.7.4"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051745 - 4-hydroxy-3-methylbut-2-enyl
                     diphosphate reductase activity [Evidence IEA]"
                     /GO_process="GO:0019288 - isopentenyl diphosphate
                     biosynthetic process, methylerythritol 4-phosphate pathway
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003966588.1"
                     /locus_tag="NBY68_RS04520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="4-hydroxy-3-methylbut-2-enyl diphosphate
                     reductase"
                     /protein_id="WP_208860970.1"
                     /transl_table=11
                     /translation="MGRMTATPARRVLLAAPRGYCAGVDRAVIAVEKALEQYGAPIYVR
                     HEIVHNKYVVQTLEKKGAIFVDVTAEVPEGSIVMFSAHGVAPTVHAEAAERKLATIDAT
                     CPLVTKVHKEAVRYAKEDYDILLIGHEGHEEVIGTSGEAPDHITLVDGPEDVANVEVRD
                     ESKVVWLSQTTLSVDETMETVGALKQKFPNLLSPPSDDICYATQNRQVAVKKLAEDAEL
                     VIVVGSKNSSNSIRMVEVALDAGAPAAHLVDFADEIDEAWLQGVTTVGLTSGASVPDVL
                     VDGVLEWLGERGYADVETVKTADESITFSLPKELRRDLRAEAAALSE"
     misc_feature    25054..25069
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.26"
                     /tool="antismash"
ORIGIN
        1 gaccctggcg gtcgtccggc tcagcgccac cgtttcgccg gcctcgccct tggcactggc
       61 gtgcgggtgc ggccatgcct ggctcgggtc ggtcaggctg acgcggatgg tgaccgcgcc
      121 cgggatcatg tcggtgagct gggcagcgag gcggtgctgg cggccggttt ccgggcaggc
      181 cgggattccg ctcggcgtgg cgagcatgcg atactccgtt gttcgtagga gcgcggtgcg
      241 gtggttctcc tgaaaaagcc cgccgcccgc gagatgtgag tcggcccctc cggggcgccg
      301 gcctggcgct ccgggagttg gtagctcccg ggcactgggc cccctcttcc ttccctgtcg
      361 cctccctctc gtccgtggcc gcagcgccta caggcgatct gccgggacca ggaccatagg
      421 gtgagcctcg ttacaagtcc acctctcaca cccgccctga ccaggcaatc accactccag
      481 tggattaata cgcgatcaac atacaccgca atcacgaacc tccgtcaacc acagtgttgc
      541 cattcgatac gatcagacgc gtagcaccac cgaagtggat gggctcgccc gcgcagcgaa
      601 gggatccgga atgaccacag agcggcagtt cgcggaactg ctcgaccggc tcttcagaga
      661 catgcacccc aaggggcgcg ggccgtacac ctacgccgag gtgtccgccg gcatccggga
      721 gagcacgggg acatccatct cggccagcgc cattcagcag cttcggaccg gctccaaccg
      781 caacccgaag ctggaaacga tcagagcgtt ggccaccttc ttcggcgtac ctccggcgta
      841 cttcttcgac gccaaggagt cggagcagat cgaagccgag ctggccctcc tgacgaccat
      901 gcgggacgcc gacgtccgcg ccgtggccct gcgtgccgcc ggcctgtcga ctgaaacgct
      961 ctcgacgatc agcggattca tcgaaagggc gcgcgcactc gaggggctcc atgacaaccc
     1021 cgagaaaccg agcgcgtgac ggtcgtcacc atgtcgattc cgcacgataa agatcaacgc
     1081 caaaaagacg cactatgtac cattttcaaa cttgatcaac tgacgctaga tcagtaatgg
     1141 ccggtctccg cattcccccc gaccattcga gcgtgatcac tgtcgtatcg tgattcggcc
     1201 gaagaacgct tcggtaagac atcgaaccgg agcattacgt tgaacctgcg cagccacttc
     1261 ggtcgggtgg gcagcagcgc ggcaaaatcc ccgaagcaca agggcttgct cgccgcgaca
     1321 gagatacccg acccgtttga cgtagagacc ttctgcgaga tgctgtccgc acaacgcgga
     1381 cgccccgtat accttcacag cactccggga atcacgtcca gcggagtccc ctgcggagcc
     1441 tggatcgcca cagagcgggc cgatcacatt ttccacgagg aatcgacttc cccgattcat
     1501 cgcacacaca tcgtcctcca cgaaataagt cacatgctgc tggaacacac ttcgttgcag
     1561 gttgaacgaa tggcgcatct cttcaagcgg gttgactcat cagccgtgaa aagtgtgctc
     1621 gggcgggcca gttacaacac ggaggatgag cgagccgccg agcagctcgc cgacctcctt
     1681 gccaggaaag ccaacttgtt ctccccgaac gagacccgaa gcgaccccgt cctgcaacgc
     1741 ctcgacgacg cgctgagcga ctcctgatct gatggcctcc ctcattcccg cagccctcct
     1801 gtggatcgtc acggtgtggc gcgcgccggc cgcctggcgt gttccggcga agcgcgctct
     1861 ctgggtggcg ttcttcgcac tgtccatagc catgaccatc cgtccggacg gtgtctcatc
     1921 ggctctggat tcccggctgg ggatccacaa cgtgacgacc ctctgcaagc acctggcagg
     1981 catcacggcc gcctacgccg tactgacctt cgtgtatgac gttgcacagg agcaggccgc
     2041 atcgctccgc ggatcacgtc cacgcatcgt cgtgcctctt accgcaggag tcggtctgac
     2101 cctgctgttc ctcgccgctc cgcagcccag ggaagccacc gacctcctca ccgacttcgc
     2161 cgatgactgg cgtatcgccg tctacggcgt catctggtcc agctacctcg gtacggctct
     2221 cgtcagtgcc actcagctgt gctggcgatg gggccgcctt ccgggagccg gcctcctggg
     2281 acgcgggctt cggatcaccg gcatggggac ggcgctgggc atcgtgtacg cggggcaccg
     2341 cgtactggcc ttgacgcttc gctacttcgg tctgacaccg ctatccccgc ggactgatga
     2401 aaacgtcagc agcgccctct tgttcggggc attgatcttc atcctcgccg gatccacctt
     2461 gccggtcgtc cgccggctcc atcaatgggg ccgtgcgcat ctcgctctca cacggctcta
     2521 tcctctctgg ctcgagctca ctgccgctgt cccttcagtt cgtctcgatc caccgcgcag
     2581 caggcgagcg gatgctcttc atttccgcca cacccggcgt cgcctgtatc gacgtgggat
     2641 agaaatccga gacgcgattc tggatctcgg agatcacgcc tccccgaccc tacggtcgga
     2701 ggccgcacgt tacgtcgcgg agaagggcct catgggcgcc caggccgaga tatacgccga
     2761 ggcatgctgg atcgccaggg ccaaggaggc gcgggaaaac ggagatgccc gcgtgggtga
     2821 gcacacagcc ccggccagtg gaggcaagga ccttcgcagc gaagtcgaag ctttgagaca
     2881 cctggcaaca gcctacgaat cagcacttgt tcgagaattc tcctccgccc ggagttcagg
     2941 atgaaactca cttcaactcg cctagcccgc atagttaccg acgcccttgc gccggcctac
     3001 ctcgtgatag ccatcctgct gatcatcggc tggcacagta cgagaagccc cgaagggctg
     3061 gcttgggggc tcctcgccgc attgttctgc ggtggcattc ccttcgccat catcctgttc
     3121 ggcgtgaaac gcgggtcttg gacggacaag cacgtcaagg tccggtccca gcgtgccgtc
     3181 ccactcacgg cgaccatggt ctccgtgctc gtcggcatcc tgatccaggt cgtcttcgac
     3241 gctccccgtg agctcttcgc tctggtcatc gccatgctcg tcggcctggc ggccaccatg
     3301 gtggtcaccg tctggtggaa ggtgtccgtg cacaccgccg tcgccggtgg agtggccacg
     3361 atcctgtcac tcgtcttcgg gccacccctg gccgccctcg ccctagtcgt cgccgcaatc
     3421 gggtggtccc gtgtccagct ccgggaccac accgtcgcgc agaccatcgt cggtgccctg
     3481 ctgggcggag ctgccgctgc cgtgacgttc gggcttctca ggtagcgcgg tctcggtgag
     3541 cgggccggct cgtacaactc gacgagcgcg aggtgtgcca tcacgccgcc ggcacaggcc
     3601 tgattcgcac cgccgagctg accccggcag tacgtcggcg aacgtcctga tcagaggatt
     3661 ccggtccacg tccacggccg cggaccggat cgaccgcgca ggcagtcgat ccggtactga
     3721 gcttggctga tccattcttc gttgctggcc gcgtgctgcg cggcgtacgt cgccatccgc
     3781 agctcccggg cgcgcgcgag gatgggatag ccctcccacg ccgtgacgtc gtgcccgtag
     3841 gccgcacaga actggtcgta ctcgcgcgcg gtgaccgcac ctgtggtctt cgcacgcact
     3901 gcggtggata cgagatccca ctccggaggc cccacggaga agcgctccaa gtccatcatc
     3961 aggaccccgt cgaccgtgcg gacgaagttg ccgggccatg cgtcgccgtg cacagcccgg
     4021 tcggggaggc cggccggccg ctcggcccag gccgccgcga ggtcgcggtg gagtccgtgc
     4081 agccactccc tgtcgtcgtc gcggatcgta gtggccgctt gcagtcgttc tccgacccgg
     4141 acgaagggat cgagatgccc caactctatg tctggcatag gcaaggagtg gagctgcgac
     4201 aggagttggg caacgtcttg gacggaaccg tgctcttgcg gtggaagttc cacccaaaac
     4261 gtcacgggcc tgccgcccgc ctcgatcggc tgctccacgt cgaccaggcg aacagccgcg
     4321 acgttctcct gggcgagcca acgcgcgacg cgcacctcac gggccgccgc agcgctctgg
     4381 cccgcccgtg atatccgtac gatcacccgc ctgcccggta gccgccatat ctggttctcg
     4441 gccagacgta gcggttccgc cccggagcag tccaatccga ccgcggaaca tgcctgctcc
     4501 aggacgttgc gcgcaggcgc ggctgccgca gaagtcatac ggaaaccgta gcggcgatcc
     4561 gctcgcgcag ccccgaagcc tcttggaccg tccgatgctt cgaggcgaag cggccgagct
     4621 gtcgtaggtc gtcggcggca cgccgggagg tgagccggcc tacctcgtcc agggcctcgt
     4681 ggccgagtgc cgctgcctgg cgggggtcgc ccttggccat gatcagggag gccagtttgg
     4741 tacgcgagat cgcacgggat cgcttgtagg cgtcggtgtg tcccttcacc gctgtgccga
     4801 atcggcgggc tgcccggccc gggtcctgtc cggcgaggat ggcgagatcg aacagagcgt
     4861 gggctgtgtc cccgttgtgc tgcgcctcgt cgtagtaggc catccacggc gagtcttcgg
     4921 caggccgggc ccgggcgaac gcttcatccg cggcgccgac ggccgccatg gtgtcgcgca
     4981 cgttacccat tttcccgaag gctctggccc gtgccgtgtg aagcatcgcc tgctccgtcg
     5041 cggtcaaacg gtcggcgcgc acgagtccct tctcggcgta ggtgaggccg tcgtcggggg
     5101 ctccgatcca tacggcctgc cgtgcgagga acgagtacgt cttggctcgg agatgccagt
     5161 cgccggactc ctcggcgcag tctgccgcga accggaacgt ctgggtggcg tcatcgtggt
     5221 ggtaggcgtc gaacgcggag gcgcccacca cgatgccgag tcgcgatacg gaggcgaaca
     5281 gttcggctcg caggtgctcg gagcactggg cctggagtag gccggccgac cactgcatcg
     5341 ctcgactggc tacgtcacgc accatgccgc cgccgcccag ctcgttgtcc atgccgctga
     5401 tggcggtggc tgcggccagg acctggtcga cgtggccggg gttgacgttc gcagggagag
     5461 tcagctcggc gggggcgaag atctcggtga ggtcgagggg tgcgatggcg gcgaggccac
     5521 cgatctggag gaacgagcgt cgaatcacgg gctcatggct cccagggcga agagtcggtt
     5581 cgtctccgcc caggatgcgg cctgccggca cctgagcggg ccccgccccc cttcccgtgg
     5641 atgccttatc ggcatcagcg ggctttctgt cggcatcgcg gttatcgaag gccatcggcc
     5701 acgcgcggtc gaacagccct cccgtacgga ggacgtcatc gagccgttga gccacgtcac
     5761 gacgacagct tggatatttc cccttctcga tcgacaagat catgtcgtcg ctgacctgca
     5821 ctaaccgccc cagcgccttg gccgacagcc cgtgctccag gcgcaggttg cgcagttcgt
     5881 tgccgaacca ctcctggggg gaggcacccg gatcgagctg cttcattggc tgcggcatgt
     5941 tctgtccccg aagtcgttga tgccgaactt ctcacctgtc ggcatcaggc tctgcacgct
     6001 ctcggtgcgc tctgcctaaa tggttgctga ccggttccag tccagtacac accgcaaccc
     6061 gcccctgctg aaggggttct ggcagaacgg aggaagcagc gatggaacta ctcgtcggca
     6121 cccgcgatcg ggacgcttct gttcgagcca cgtccagaag cgtgggcggt caactcgaca
     6181 tgagtttcga agtccgggcc gaagatctgg gaaccgtcag gggcatcgtc gcggcgcacc
     6241 tttgctggtg gcgcatcgac gacagcaccg cgcaccgcat gctgacggtg gtcaacgaac
     6301 tgatcaccaa cgtcttgcag cacacggcgg cggacaccga tggatgccag atggccagcc
     6361 tgctcctcca gaaggtgccg gacggagtca ccgccgtcgt ccgcgaccag gactcttgcc
     6421 tgcccgttta cgcgtctccg gacctcctgg ccgaagaggg gcgcggtctg ttgttgctac
     6481 gcgccctggc cgacgacacg tccgtatccg tgaccccagg gggcaaggac gtgtgggtct
     6541 tcatagggtc cccggaaacc cccgaacgct tctaaccccc cacggccggc acttggccct
     6601 ctacaggagt tccgatgtcc ctcaccgctc tggttccgga gaacgacgtg gttcctccgc
     6661 cggccgacga gccgagcatc acgcagtgga cacctccact cgatgtagag ggcttgaggt
     6721 ccgtcctgga gcggatcaag gactggaagc cgctggatgt cggggaagtc ttcgacgacc
     6781 tcgacactgc gatcggcaat cagccgccgc cggtcacgac ggccggcgtc ttggtcgacc
     6841 gcctccgcag ccacttgaag cagctcagcg acatcgccct cgcggacgag cagtttccgc
     6901 ccacccgggt gatggtccag ctcgttgaaa gagggctccc cctgaggggc gagcgaacgc
     6961 cgaccgcaca tcggcaggtt gtcggccttg ctcgtcgcct ggccttcgtg acctccgacc
     7021 tggtcgaaga gctgatcgaa gcccgctaca tcacggaggc ggaatgatgc gcaacccctg
     7081 cgccgtcaga cacgctcccg tgaccgccac ggcggtatcc cttccgcgag acgcgtacga
     7141 cttcggctcg tcctgcccgg acgcctgccc cgttccggac gcccgccccg ttgtcgagtg
     7201 gggagagaag ccaccgatgc tccggggcga ccgcagcgtc accacccttg gtcggcttct
     7261 acggctacag cgaaacagcc atcaccgact tcttgcagcg gcgcgacacg actccctctt
     7321 cggccatctc cattccgtgt tcccacacgg caccgtagct cgccggagag ggcccgactt
     7381 cccacccgag aggacgagca cgatgtgtgc gcacaacccg ccgtgccccg tggccgaggc
     7441 tcccgacagg gaggccgcgc gccccgtcac gcaccgcccc gagcagggct ggagcctgct
     7501 gtgcaacgga gtactactct tcgaggacac gggcgaaatc cttcccgacg gccgtgtgat
     7561 cgccccgcgc cggtccctcg acagggcgag ggcagcggcg tgaagcggtc cagcgcagca
     7621 ccgagactcg tcccgtacat cacttcccgg gagggtgagt acggcgcgct ggagtcggag
     7681 ctcacgctgc gcatgaacgt cttcggcgcc gtacgtctcg cttaccacga cgagactccg
     7741 gccgaccgag gcccgcgcgg tgagctgtgg gcccggtgtt cccagtcgct caacactgcc
     7801 gggaggccga cgggcaaacc gcagtggcgc ttagtcaacc ccgcccggca gcgggcagcc
     7861 atgcagcagc ttcgctgcca gatcagcttc tgtccggccg aaaccgcccg ggggtacgtc
     7921 ttcctgaccg gagctgcgga agacccctct catcgccccg gtgagccggt gaggacggcc
     7981 cagccgccgg tgtgcctgga gcacgtgcga ccggccgtcg agttgtgccc gcatctacgg
     8041 aaggggcacg tcgccttgct cgcgggggcg acatcggtct ggggtgtcat cggctcccga
     8101 taccgcctca ccgccaccgg cctggagccg cttcctgccg aggacgacga cgcgcccgtg
     8161 gcgtacgggc actcgcagtt gggctggttc ctggcaagcc aactcgtgcg cgaactgcac
     8221 gactacgagg tcgtcaatct ggacgatctc gtgcccgccg catagacggt cgcccggcgg
     8281 tcctgagtga tacggacggg actgccgggc ggctcaccac cggcgccgga gcactcgtgc
     8341 accgtccatc ccggcccacc ggcacgccgt gctggcctgc ctcccccgaa caggtacgac
     8401 cgaaggaaat ccatgacgaa cacgaccgtc gagcccaacg aggcgacccg cctgcggaac
     8461 atggtggtgg acgagctatg cgcggacggc aacatctcct ccccggagat cgaagccgtg
     8521 atgcgcaagg tgccccggca ctcgttcacc cccggcaccc cgctggacaa ggcgtacgac
     8581 aggtacgccg ccgtgatcac caagacggac gagcacggcg tgcagcttag ctctgtctcc
     8641 gccccgcaga tccaggccat gatgctggag caggcccagg tgaagcccgg catgcgggtc
     8701 ctggagatcg gctcgggcgg gctgaacgcg gcctacctcg ccgagctcgt cggtgaggac
     8761 ggtgaagtcg tcaccgtgga catcgacccc gtcgtcaccg atcgcgcgcg acagctcctg
     8821 aatgagcacg gctacggccg ggtgcacgtc gtcacggccg acgctgccga gcccatcccg
     8881 gacctcagcg aggtcgacgt cgtgatggtg accgccgggg cctgggacat ctctccggcc
     8941 tggaccgcgc agctcaagca gggaggccgg ctcgtcgtcc cgctgcggat gcgcggcctg
     9001 acccggtcgg tcgccttcat ccaggtcgag ggcgagcacg gcgcctacct ggagagcgag
     9061 tcggcgcgga tctgcggctt cgtcccgatg cagggttcga ccgctcaccg ggaagaactc
     9121 ctcctcgtca acggcacccc ggagatcggc ctcaagttcg atgacggcct gccggccgac
     9181 ccgcaccggc tcgataacgc cgtcacgttc ccgcgccacg aactgtggac cggtgtcacc
     9241 gtccgcatcc aggaactcat cgacaccctc cagatggcga tggcgatcag cctgccgggc
     9301 ttctgcacga tggccgtcga tgagaactcg gacacgggcc tggtcgaccc cgtgaacaag
     9361 cggttcgccc tcgcggccgt cgaggacgac accttcgcct acctcgtcac ccgccgcacc
     9421 gaggacaaca agcacctgga gtacggcgtg cacgccctcg gcccgcacgc ggaacggttc
     9481 gccgacaaga tcgccgacgt gctccgcgac tgggaggcca accggcgcgg cggccccagc
     9541 ccggtcatcc gggtctatcc ggccagcacc cccgatgacc agatcccggc cgaccgggtc
     9601 atcgacaagg tccacagccg gatctcgctc tcctggcccc cggcgtaaca ccgggagcca
     9661 ggtaatcccg caccacccca acgagaagaa gggcacatca tgacgagcgc cactctcgcc
     9721 ccgcccccgg tcgcgcccgc cccgcttgcg ggcctggacg acgacgactt cgcgcccctg
     9781 gacgtgaagg tcgtcatcgc cgagcactcg tacggccatc tcatgtgctc cacgggcgac
     9841 ggctgcggca ccacctgcgc gaccggtgcc tccgcctgcg gttccttcac ggaggacccg
     9901 gcctgatcca ggccgacccc tcacctgtgg gccgggcgaa gcgcttcgcc cggcccacag
     9961 gcccctctcc cctccccgcg ccgcctcatg gaagggcctc atggcttccc gagcagccgc
    10021 cggataccag tggcaaggcg ttgcgatgct gcgcgccacc accagccccg ggccggcaga
    10081 catcccccgt accctcgacc tggacaacgt ggccgtcacc cgcggatggc tgaaccgcat
    10141 ctggcagcgc gaggacttcc gcagcgcgct ggagctggcc acccccgtcc tgtccgacgc
    10201 catcgaggcc gtcgtccggg gccggcagac tgagccccgt cacgtccgcc gcaccgcgct
    10261 gtcgacggtt tcctatctcc tgcggtggca gcaccggccg accccgctcg gcctgttcgc
    10321 cggcatcgcc ccggtgtccg tcgggccccg ggcgagtgcg cggtggcgcg aaaagcaccg
    10381 cacgatgatc cggccggacg ccgaatgggt caccgacatg gttctccggc tccagcgcac
    10441 ccccgcgttg ctgaagcggt taccgctcgt cgccaacaac gccgcccgcg cccgcggtga
    10501 ccggctcgtg gcatcgggcc cgccctccga cggtcacgcc gtcctcttgg ccccggtcga
    10561 gatatccgtc cgcaacgcct ggccggtggc cgccgccatg gacgcggccc gcacccccat
    10621 cccttacggc gacctccacg gccacctgcg cgaccgcttc ccgcaggcca caccggagaa
    10681 gatcgacgcc cttctcacca gcctggtcga gcagcagttc ctcatcacca gcctctgggc
    10741 gcccatgacc accgcggacg ccttccagca cctgtgccgc gaactggacc ggcaccaggc
    10801 ggatgacgtc cccgatgtgc gggacctggt ccacgcgctg tacgccctgc gcgacgagct
    10861 gtccgcgcac cagccgacgc tctccgacac cagcgtgagc gccgtcgccg cgcggatgtc
    10921 cgccctcacc accgtcaccc cgacaccgct gctcattgac accgccctcg actgcgagac
    10981 ccaggtcccg cagtccgtga tcgcggaagc gcaggcagcc gtgtcggccc tctaccggac
    11041 caccccgcag ccctacggct accagcactg gcgcgactac caccgccgct tccgggcccg
    11101 gtacggcgtc ggcgccatgg tgccggtgat ggacctcgtc gccgacagcg gactgggcct
    11161 gcccgccgga tacgtcggct ccgaacgcgg cgccgccctg aaggtgcgca ccgaccgcga
    11221 cgagctgctg ctcgcgctgg tgcagcaagt cctcctggac ggcgaccgtg aactgcggct
    11281 gacggacgac atagtcgacg ctctggagaa ggccgccggg aaggacgagc ggctgttcgt
    11341 gccccgggtg gaagccgcct tcgaggtcca ctcacccagc acccgggcgc tgtccagcgg
    11401 caccttcgac atcctgctca ccgcggtccc ccggcccggc agcagcatgg ccggccggtt
    11461 cgcccacgtc ctgccgcccg agcatcagga cgcgctcgcc gccacgtacc acggggcgcc
    11521 ggacgccctc acagcgcagc tcgtgttccc gccgcgccgc caccgcaacg agaacgtcac
    11581 ccgtacgcct cggctgctgc cgcacgtcat cgagctgtcc ggccaccagg agacggacga
    11641 gacgacgatc cctctcgctg acatcgccgt caccgcggac ccgcgcagct tccacctcgt
    11701 gcagctctcc accggccggc gcatcgacgt acgcgtcctg cacgccctgg aaggcgggac
    11761 acagacacca ccactggccc gcttcctcgc cgaagtggcc aacgggcggt acgccgccta
    11821 caagccgttc gacttcggcg ccggctcccg gctcccgttc ctcccgcgcg tgcgctaccg
    11881 ccgcaccatc ctcacgcagg cccgatggct gctgatggcc gacgacctgc ccggccgcaa
    11941 agccgcgacc gaggagtggg agaacgcctt caccgcctgg cgggaccggc tgcgggtccc
    12001 catgcaggtc gccatcatcg agtacgacca gcgcctcccc ctcgacctgt cccacccgat
    12061 ccacctccgg accctgcgcg cccacctcga caacgcccgg cgcctggaac tgcgcgaggt
    12121 cccggacgca gacgcccacg gctggatcgg acgggcacac gagatctggc tctcgctggg
    12181 ccggttgcag ccggacaccg ccgatgtgcc ccggccgcgc cccgccgccc cgccgacccc
    12241 cgggcggcac cttccgggcg ccggtgacgt cctgctcgcg cagcttcacg cccacccgcg
    12301 ccgctacgac gagatcctga gccgccacct gcccagcctc ctcgccgcgt tcggcgacac
    12361 cccgccggtc tggtggttca cccggcaccg agagatggcc cgcccggacg ccgaccagca
    12421 cctcgacctc acgctgcacc tgccgccggg cgcatacggg accgccgccc agcacatccg
    12481 tacctgggcg gacagcctgc accggctcgg tttggcgtcc gggctcgtcc tgacccccta
    12541 ccagccgcag accgggcgct tcggcggcgc agcggccatg gacgccgcgc accaggtgtt
    12601 cgccgcggac tccgccgcag ccctcgcgca gatccagctc accgagcgca ccgacgccgt
    12661 cgccccgcag gccctcgccg cggccagcgc cctgcacctc gtcacccccc tggcgccgaa
    12721 caacgcggcg gccgaggagt ggttggtgcg caaactcccc cagagcacgg ggcgactgaa
    12781 ccgggccctg cgtacccagg tgctcgaact cgccgtgccg aacggcgcct ccgcgctcgc
    12841 ggccctcccc ggcggccctg cggtcgccga agcatggcgg gcccgcgccg ccgccgtgga
    12901 cacctaccgg aacgccttga ccggccaacg tgatccgctc ggcgtcgccc gatcgctact
    12961 gcaccagcac cacgtccggg ccctgggcgt cgacccgcgc accgaggaga ccacgatccg
    13021 gctcgtacga accgcggccc tccagcaccg gatggccgcc cgatgaccgc gccgaccgtc
    13081 accaccgcag cgatcctgga gcagtacgcc gcccacctcg ctcaaccagc tcctccgccc
    13141 ccgggcgagc cttggtcggt gcagtccctc gccgacggcg ccgccggaat cagcctgctg
    13201 cacatcgaga tggccagccg tcacggcggc tcctggcgca ccgcccaccg gtggatcacc
    13261 gccgcggcaa ccgggcatat cagcgcggcc gacaccgcag ggctgttcct cggcgccccg
    13321 gctctcggtt tcgtcctcac caccgttccg ccgtgcttcc agcacctgta cgaaccggcg
    13381 cgccagacgc tgcaccagca catcatcgac ctgtcccacc gccgcgtgga cgccgcgctc
    13441 gcccgcatcc gcaagggcga cctgcccacg ttcgccgagt acgacctgtt ctacggcctc
    13501 accggcatcg gggcctacct cctgcggacc gaccccgaag ggctccccct ggaacgagtc
    13561 ctggagtacc tcgttgccct gacccgcccc ctggcccccg agggccgcgg cctgccgggc
    13621 tggtgggtcc gccatgaccc ggcccgcggt gaatcccccc acttcccggg cggccacggc
    13681 aacttcggcg ccgcccacgg catcaccggt ccgctcctcc tgctggctca ggccatgcgc
    13741 cgcggcatca ccgtcagcgg ccaccgcgaa gccatctgga gcatctgcga acacctcgac
    13801 gcctggtgtc agctcagtcc ctccggcccc tggtggcccg agcacatctc acgccgtgac
    13861 ctcgacctcg ggcgtccgca ccacgacgct cccacccggc cgagctggtg ctacgggacc
    13921 acgggcatcg cacgggctgg gcaactcgcc gggctcgcct tgcgcgcgcc cgacgtccag
    13981 gcgttctacg aggacgccct gtaccgcgcc ctgaccgacc cggaacagct cgcccacgtc
    14041 gccgactcgg gtctgtgcca cggctgggca ggcatctacc agaccgcaat ccgcgccgcc
    14101 gccgacgccc tcgaccaccg acttcagacc ctcccgaagc gcctcggcga gaccctcgtt
    14161 gcacaagccc aacccggcgg ccaccccacg accgggttga tcaacggcga tgccggcacc
    14221 gcgctcgccc tgaccaccta tgcctcacag caggccccga tcaccggatg ggactcatgt
    14281 ctcctgatca actgacccag gcggaatcac ccctgatcca gaacgcggtc ctcgccgtcc
    14341 tcaccggact accgatcgcc gacgccgcgc accagtaccg gatggacacc gtggccctgt
    14401 ccagcgccgt caaggtctac gaccaggctg gccgagaagc cctggaccgt cgctccgcct
    14461 ccaccgactg gtggcaggca tacctccact tcaccgactg ggcgaacgcc gacaccacct
    14521 tcaccacaca cgtgctgccc gtcctgcgag acgctgaagc agccggcgcc atcgacggct
    14581 ggtggtacac ccgcaagcac ccctgctggc gcctgcgtct gcgcgtacgg cacacgatcg
    14641 ggcccaagtt gactgtcggc gacgacttgg atcgcctcgt cgccgacggg catctacaac
    14701 gatggtggcc cggcttctac gagccggaga ccgcagcatt cggaggagca gccggtatga
    14761 cggccgcgca cgccttgttc atcactgaca gccgggaggc acagcagtta cggcagcgcg
    14821 gcaacctggc cgtgggtcct cgcgagctgt ccgtccttct ctgcacgctc atgatgcgcg
    14881 cggccaaact ggagtggtac gagcaaggtg atgtctggca ccgcgtcatc acagaagaac
    14941 accgctcagc catcaacgac gtcccgacca ccagcctcga cgcccgcgcc cgggagatcc
    15001 ggcccctgct cttcgccgac accaacgccc tgctgcgccc cggcggactg ctggagcccg
    15061 tcgccgagtg ggccaccgcc ttccgcgacg cggggcaggc gctcggccac gccgtccagg
    15121 acggaaccct cgaccgcggg ctacggcagg tgctcagcta ccacgtgatc ttccactgga
    15181 accgcctcgg actgtccatg cggggacaga gcatcctggc ctgggcggcc agggcagcga
    15241 tcctccacgg agagaacggg gcgtgacccg ctacgaacag agccttttac ctcgcaaagt
    15301 ccctgcgctc cgactagcct tcctaaggcg taggggacgc ggatcaggca gcgacaggtg
    15361 gggttcgtgg ggttctggca caccggctac atggagttcc atgagccaac cggattcgag
    15421 tcggtcggac tgccagcccc gccaaagccc cctgcttttc cctgcactga gtgtggactc
    15481 gtcttctcgt ccgagcgcgc ccgccgagcg caccacttcg acggtcatgc gactaagcgg
    15541 cctaccctcc tcttcagggg acgagagtgc gggcgcacgc gcttgatggt cacgagctcc
    15601 agtggcttcg ccgattgggt gacctcggat gtcgaatcca tcaccgtcaa cggccgcgag
    15661 acctcaacat ctgaggccgc cagctacctt gcctcggtga aggttggcgt ccagacagtg
    15721 gcagttttca atggcccgct ggagcgaacg ttcgagttcg acttctgcct agcagaggaa
    15781 gaagacctct gcctcgtcga ccacgccttg gagaagctca tctccagtcg cgagttgagt
    15841 cgcagcgcaa tcgacacctt catcatgcgt gctggccgcg gggtgacggc ccgccgttac
    15901 cgcgaaggtc tggcgacata cctgtacggc gtgcttgcgc gggaggcggt cgaggacccc
    15961 ggccgggtgg atgcgtcggg tgcaccgctc tacgagcagc ggtacaacag cgctgtctct
    16021 ctactgtcaa cctttgaccg gcccgcagcg gaagcgatct gcggcttggt tgcgttgcac
    16081 tacaaccagt tcgaacttgc ggtgcgcaag accaacagcc accgcatctc cgatgtcgcg
    16141 gcgcggttcc gatctctcct cacaggcggc acatccgtca cgacaagcct ggccgaccgg
    16201 tcgcacggaa gcttcgatca ggccttgagc gactccgtta ccgaggacct cctggacgtc
    16261 ggcgcagcgg ctttggacgg gactcagtca cccgtggtta cccagctgct gccctcgctg
    16321 ggcgagctcc ggccccagga ccagttcaaa gtccgcctca tcgcggctga ggcgttgctc
    16381 gcagcgggag acatcgatgg tgcatcacga cacggcgagg cgatcaggca ctctaatgag
    16441 accggcgcct ggtacgcagg atttcggata cgactgcaag aggtaggacg ttgagcaacg
    16501 agaccattcc agagcccggc gcggagccgg ggccggacga ccccgcgtcg gctaacgctg
    16561 ccggcgacgg cgaggcctca gccgcaccta ctgacagtgc gccgacggca tccgtcgcgg
    16621 aggcgggccc acatcgggcc acgtccaaga cgaagacaaa gccggtcatt acctcgatcg
    16681 atgacctgct gacgttcgca tacgagtcga acgctcgact gcttgacctc ccgaaggagg
    16741 ccctcaagaa gctggcgatt accgatgagg gtctcgtgtc acaaagcgta ctaatcgggt
    16801 ctaaagcgcc gacagaccca acattgtcga ccccgttcaa gctgcttcag tacgcggcgc
    16861 gtcagggggt cccgctcaag cgcgccgaga gtggtgacct cgcaccggcg ttgaaccggc
    16921 tctttgacct cgcggtagtc gcactgggcc acagtccggt gttccgggtc tgggtgaacc
    16981 agctggtcga tccctgcaag ggtccgcagc tctcgaccga acacttgcgc agcatggccc
    17041 gggaggtctg cgccgacgat cttggactgt ccccagacca gttcaagacc gctgacagtg
    17101 agcgcctcgt caagaatgcg atcgcttgct acagcctcct ccgcgtgctc cagcgtgagt
    17161 ggaccctgga tcagttcatc gatgcgtcgt acggctctgt ctggaggtac gaggccccaa
    17221 aggcagcagg gctggagcga gccgccagcc aggtcggggc aagcagcgat ctcgatgtgc
    17281 tcgggattgt cggcgagaac taccgagcac ggatcgcccg cctggatcgg caggtcacac
    17341 aactcgagca tgaggccgac gctgctcgaa atcgcgagac tcggctccgc agtgagcttt
    17401 cgaccgtcga ggagcgtgag caatctgcga tggctcgcgc cgactcgttc tctgccgacg
    17461 tggtgcggct gcagaaggag ctcgcggctg agcgcgacaa cagagtcgtc gacaaaagcc
    17521 acatgacgga cgattacgag acgctgcgaa cgcgcatcat ccggcgtctc gggggtgaga
    17581 tcgatctact gaccgatggt ctgcacgcac tccggaacgg tgcgcccaac gtcgcggagg
    17641 agttcctcga ccgttccctg cttgccctca cacgtgaggt cgagcagctg aaggacgcgt
    17701 ctggaggctt cgcgtgatcg tcgggtttga cttcggaacg accaacagcc tggtttcggt
    17761 ggtagttggt gaccgcgtga tcgacgtgat ggacgtcgaa actggccggc cacacccctc
    17821 gatcgtccgg tatgaaggtg agcaggtagt cgtcggccgc gaagccaagg acgcgttggg
    17881 tgcggcgggc attggtgtgc acggcaacac ggtgaaatcg ccgaagttcc tcctcggcga
    17941 ggaggtaatc gccgtcggag gcgtcgaccg gagcccggtg gacatcgtta cggacgtcgt
    18001 gcggcacgtc cgatcggagt ccctgcgcag tccgcagcgg aaggtgctcg gcggcctcga
    18061 cagcgctgtg gtcacgatcc ccgtgaccat gaatgggcac cgacgcgcgg cgctgcgaga
    18121 ggcgttcgcc ggggccggga tgcgtatagc ccagttcgtc cacgagccgc tcgccgccct
    18181 gtatgggttc atccggggag caaacgaccc agaagagatg gcgcggcgtc ttgcacgacg
    18241 aaacgttctg gtcgtcgact ggggcggcgg aaccctggac ctgactctct gccgggtcga
    18301 cgaagaacag gtgagacaac ttcgtaacgg tggctcggcc caggtcggcg gtgacgagtt
    18361 cgacaaggtg attcgtgacg aggtcgtaaa gcgcgttcgg gctcgcggaa gtgccactga
    18421 ccaggacctt gcgatccctg aggccgaact ccggctcctc caggacgcgg aacgcaacaa
    18481 aatcgagctc tcggctgacc gagttgatgt gacgttctac cggccaagtt atttccaatc
    18541 aggtgccacg ttgcagtacc agctcacgcg tcaggagctg gaggagatca cgcggccact
    18601 cgtgacggca ggtattgatg agatcgagtc gctgctcggc agcttgtcga tggcgcccgg
    18661 ccaggtctcg ctagtcgtcg tggtcggtgg catggcggcc atgcccgcga tccggagccg
    18721 gctgtacgag atgtttggtc cggaccgagt tgaggtgccg acgaacagcg ccacattgat
    18781 ctcacaagga gctgcgtgga ttgcgcatga caggcagagg ctccgactgg caaagcccgt
    18841 cgaactcgag ctcgcccgtg ggtctctgat gccgctcctc gctgcgggca cggaaatgcc
    18901 tctcggtgga gaggtcaagc acgaaaccct ccacctgtac tgcgcggatc cgacggacgg
    18961 gaaggcgaag ttcccgatcg ctactccgac cgccttgtca tcacatccgc aggcgagtga
    19021 gcggcgaacg tcgctgggaa tgatcacaat cggcgtcgat gaggccgcgc cgccactaca
    19081 tgagcgcctc gagcttaagg tcgctctcga cgacgacttg gtgttgtcgg tcgaggcgtc
    19141 atcaagccag aagcgcgatc gagtcacggc gtcgtactac gacctggagt tcggtcttgg
    19201 cctcccggct tctgctatgc ccggaggtgg tgccgcagac ccaaaagcac ctgaggagtc
    19261 catagtcatg ccacaggcag gactggtcgt ccgtgcgaat gtggcgaggg acaaggacca
    19321 ggcgtctgtt cccggcgacg tgctgtatcg gcacaattca ggggcattcg cccggcacct
    19381 gcgcgacggg gcgacagaag ctcagttgct ggagcacctg tactaccagc cgtgctccgt
    19441 ctgcaagcgc cagtgggggc acccggagtg tcgatgcggg acggcgtgac atggcgagcg
    19501 ccaaggcact cgtgcgagtg cttgaccacg gaacggaagt cgagtctgga gtccgccgtc
    19561 cgattcgtct gactcccgat ggatatgcgg gcgtcgcgta tgcgggctcc gtctacccac
    19621 tccggcaggg cgatctcatc gacttgggcg gatcgagctg ggaactcgcg gactgcgatc
    19681 gtttcctgtt cgccggagca gatgttcctt acgctcccgc tgtcggtgaa ccgctggaga
    19741 gggccagcgg tttcgacgtc gagtggcacc tcgaaactaa ccagtacggg cattacgtcg
    19801 tcttcaacgc gtcagagcgc gttgccagca gcttggtgtc agcacttgag ggcgcagatc
    19861 tcagcgtcca gcgctgggac gtaagccatc gtccagcagc cgacggcaat ttctacgact
    19921 ggttcgcgcg tcttcggttc aagggcagcc aggccgaagc acttgcgctc gtcggggctg
    19981 tcgtcgcacc gccgtcgtct ctcgcgccga cggtgccagt cgcggatccg actaccgctc
    20041 gactcgctga tgccgaggcg cggatcgagg aactgctcaa ccagctttac gtcgcgacac
    20101 ggaagggaga ggctgctgaa cgtgagctcg cgcagctccg tcacgatctc gcgaacgccg
    20161 aagcgagcga gcatcgatat cgagaatctg ttgcccttgc agaacgccat catgcagatc
    20221 tacatgagca actctccgtg ctccgacaag gcctgggagg cctggctgac acggcggagc
    20281 tggtaaagag cctcgctgac gccgaggaac ttcgagaact cgctcttgcc gacaactcct
    20341 tgctgctgga gcgtgtgcga gcggccgact cggaagtcgc agaaagcgga gcacgcgctg
    20401 gcgacctggc ggtgcaggta gacgcactcc ttgggagagt gtcggaactt gaggcgctgg
    20461 agactgagcg acttcgcgcc gcgaccgcgc aacggcctcg gcgaggcggt gtcattgcat
    20521 tcctgcctca ggcgttcagc cgcctcgagt tcgttctcga tgcagtcgac gtgatcgcca
    20581 acctcgaatc gccggcgtcc acgatgagag cactagctga gatcgactct gggcgccttg
    20641 ccggaaagga ccttgaggga gtgagtggct ggttcgaggt gacgaaattg gcgacgggca
    20701 tcacgggaag tgaacgactt ggccgcatct actacaagcc ggacggccca agaatacttg
    20761 tcagtgtgca catcaaacag gacggcaaac agcagagacg ccacatcgag aggctgcgag
    20821 ccttctgacc ccatttaacg acgcctgagg gcagcctcga gtcgggacag gtactcgacg
    20881 acgtggcgcg ggacgtcgag cgtggcgacg taggtaacca acgtgaagcc tctgtggata
    20941 cggacatctg tcctaccagg ggctttacgt ctgcctagag ccgggctacc cggactgatc
    21001 catccgggca tgtgccgatc agcccgcttc acggagatca ttccgccgag aaagcctcac
    21061 tgcgcacggc ggacggaatc gagttggtcc gtgctctggc ccagaaaccc cacaggaact
    21121 catcgaactc aaggccaccg cccacatcgg tgccgcaccg ggcgagcaca ccgagacccg
    21181 cacaggccgg ggatttggac ctggcgatcc ccaagctccg cactggatct ctcttcccat
    21241 cactgctgga acgccggcgt cgaatcgacc aggccctcta caccatgatc atggagaaca
    21301 tacgtccacg ggtgtccact cgcagcgtgg acgacctgct caaggcgctg ggcggggcgg
    21361 catcaccgag gacccgcgga cgcgaagtcc tcggacgcat ggtcggcgac agcgagaccg
    21421 atgcgttctg gaccgagttt ctgcgctccc tgcgtgaacg cgtcctgacc gggggtccgc
    21481 ctggtcatcg ccgaccatca ttccgggctg gtgaaggtgg tccgcaaggc cgtgctcggc
    21541 gccgccctcc agcggtgtcg cattcagttc ctgcgcaacg tcatctccgt gcgatcagca
    21601 aagactccgg cgagatggtg gccgcgacga tccgcacgat cttcgcccag cccaccaccg
    21661 aactggtccg ttccagctcg acaccgtcgc cgacatgctc ggacggcagt ttcccaaggt
    21721 caaagccatg ctcctggcag ccgagaccga cctgaccgcc ttcgccgagc ggatttggaa
    21781 gaagacggga gatcaagcac cgcgtcgacg tcgtccagat cttccccacc ccaacgccct
    21841 cgaacgtctc aacactgccg tcctcatcga gatgtacgac gaatggatcg cgttccccca
    21901 cagctgcctc cccaacggcg gcacggactc ggtctacccc acgaccgaag atccccgacg
    21961 cggttacacc gccacaagga ccgggctcac gatgcacgac ctgggcaccg ccgagctgga
    22021 aggcttcctc cgcgagcact gcctcgtccg ctcgacactg ggcagacagc ggctcaagtt
    22081 tgcgccgaag gctcaccgtc ccgatcgtga gcgacacttt ggcgacttcc tggagtgagg
    22141 agaggggctg tccgggcggg ccgggagtgg accgattctc cagtttacgg gcggggccgg
    22201 gcggcccgtc acgggtgcgg aggcggaggc ccgtccacgg ccgaacggtc ctgtttcagc
    22261 cgtgtgggat cgaacgcaac gccaaggtca cccaaagcgc gtgtccaacg cccgaaagag
    22321 tgcacccggc gacctaggtt gtcggggtgg agcagcacag gacacgtacc ccgcagcgca
    22381 ggcagccccc gcagggccgg cccgcccagc ccggcggcct cggtgaggtc acggccccgg
    22441 ccgcataccc ggtgacggtg gcggtcgcac cggtgacggg cccggcgccg ggttcccggc
    22501 ccggcggcgt tccgcctgtg gtcatggcgc tgcgccgatt ccccaacccc cggctgaccg
    22561 gcatcggcgc cggactcttc gcggcactgg ccatgttcct gctggcgtgc ctggaccggc
    22621 ttcttctgga cggttccgaa ctcgtgtacg ggctgctgtt cctgcccgtc agtgccctga
    22681 ccgccctctg ggtccggccc gccgacctgg tcacggcccc gatcatcgtg cccatcgcct
    22741 tcgcggtcgg cgtgatcccc gtagcgggcg gcacgggcgg cttcggcgga caggcgatgg
    22801 ccgtcgtgac cgcgctcgcc gtccatgcgg gctggctgta cgggggcacg ctcatcgccg
    22861 gtctcatcgc caccgtacgg aaggtccggc agatgcggga gcggcagcgc cacctgctcc
    22921 gggccgaccg ggccgaccgg gccgcccgcc gcccccgcgc gtaggtccta cttgcctgcg
    22981 gccgccatgg ccgcgccgac gatgcccgcg ttgttctgca gctcggcggg gaccatctcg
    23041 gcccgtacgt gttcgatgag cggcaggaac ttctccgcct tgcggctgac gcccccgccg
    23101 atgatgaaga gttcgggcga gaacagcatc tccacgtgga ccaggtattt ctgcacccgg
    23161 tgcgcccagt ggtgccagct cagttcctcg tcctccttgg ccttcgtgga ggcgcgcttc
    23221 tcggcgtcgt ggccgtgcag ctccaggtgg cccagctcgg tgttgggtac cagctgcccg
    23281 ccggtgaaga ccgcgcttcc gatgcccgta ccgagggtca gcatgatcac cgtgcccttg
    23341 cggccgcggc ccgcgccgaa ggtcatctcg gcgactccgg cggcatccgc gtcgttgagg
    23401 atcgtcacgg gctgcccgat gcggtcgctg aggagcgccc gggcgtccgt gtcgatccag
    23461 cccttgtcca cgttggccgc ggtcctggtg atgccgccgg tgacgactcc ggggaacgtg
    23521 atgccgaccg gcccctgcca gtcgaagtgt ccgacgacct cggccacacc gtcggccacg
    23581 ctcgcgggcg tggccgggtg aggtgtcagt accttgtggc gctcctgcgc cagctctccg
    23641 cggtccaggt ccacgggcgc acccttgatc cctgaaccgc cgatgtccac accgaagatc
    23701 ttcatgccgt ccacggtacg ggcaggtggc gcggatcact ccccggaggg gggatccggt
    23761 gggagcgccc gggtcactcc gcgcagagcg ggcgcaccgg gctccacccg ggtcactcgg
    23821 agagcgccgc ggcctccgcg cggaggtcac ggcggagttc cttggggagc gagaaggtga
    23881 tcgactcgtc ggcggtcttc accgtctcga cgtccgcgta accccgctcg cccagccact
    23941 ccagcacgcc gtcgaccagt acgtcgggca ccgaggcgcc cgacgtgagg ccgaccgtgg
    24001 tgacgccctg cagccacgcc tcgtcgatct cgtcggcgaa gtccaccaga tgggcggcgg
    24061 gcgcgccggc gtcaagggcg acctcgacca tgcggatcga gttggaggag ttcttcgagc
    24121 cgacgacgat gaccagctcg gcgtcctcgg ccagcttctt caccgcgacc tggcggttct
    24181 gcgtggcgta gcagatgtcg tcgctcggcg gggagaggag gttcgggaac ttctgcttga
    24241 gcgcgccgac ggtctccatc gtctcgtcga cggagagtgt ggtctgggag agccagacga
    24301 ccttcgactc gtcgcggacc tcgacgttcg ccacgtcctc cgggccgtcg accagcgtga
    24361 tgtggtcggg cgcctcaccg ctcgtgccga tgacttcctc gtggccctcg tggccgatca
    24421 ggaggatgtc gtagtcctcc ttggcgtagc ggacggcttc cttgtggacc ttggtgacca
    24481 gcgggcaggt cgcgtcgatc gtggcgagct tgcgctcggc ggcctccgcg tggacggtcg
    24541 gggcgactcc gtgcgcggag aacatcacga tggagccctc gggcacctcc gcggtcacgt
    24601 cgacgaagat cgcacccttc ttctcgagcg tttgcacgac gtacttgttg tgcacgatct
    24661 cgtgacggac gtagatcggc gcaccgtact gctccagggc cttctcgacg gcgatcacgg
    24721 cgcggtccac gcccgcgcag tagccacggg gtgcggcgag caggacacgg cgggcaggag
    24781 ttgcagtcat gcgtcccatc gtaaggccgt accgaacagg cgccgggaca gcggggtcgc
    24841 gagactgatg cgtacgcagt caagcgacgg aggcttcatg gcgggcagcg gcagcagcgc
    24901 ggaagaggga aagctgcggc gcacactcgg gttccgggac ctggtggtct acgggctgct
    24961 gttcatcgcg cccatggccc cggtcggcgt gttcggcacg ctggacgccc ggtccgacgg
    25021 ggccgtggct ctcgtgtacc tcgtggcgac cgtggtgatg gccttcacgg cgttcagcta
    25081 cgcccagatg gtccgtgtag cgccgctcgc cgggtctgtc ttcgcgtacg cccgcaaggg
    25141 gctcggggag gggcccgggt tcatcgccgg gtggatggcg atgctcgatt acctgctcat
    25201 cccggcggtg gcctacctct tctccgggat cgcgatgaac gcgctggtcc ccgaggtgtc
    25261 gcagtg
//
