LOCUS       NZ_CAKMXI010000002     10204 bp    DNA     linear   CON 03-JUN-2024
DEFINITION  Streptomyces atroolivaceus strain TUE2108, whole genome shotgun
            sequence.
ACCESSION   NZ_CAKMXI010000002
VERSION     NZ_CAKMXI010000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces atroolivaceus
  ORGANISM  Streptomyces atroolivaceus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 793806)
  AUTHORS   Wibberg,D.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-FEB-2022) CEBITEC, Genome Research of Industrial
            Microorganisms (GRIM), Universitaetsstrasse 27, 33615, NRW, Germany
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_928722305.1-RS_2024_06_03
            Annotation Date                   :: 06/03/2024 04:23:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,057
            CDSs (total)                      :: 6,983
            Genes (coding)                    :: 6,683
            CDSs (with protein)               :: 6,683
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 2 (5S, 16S)
            complete rRNAs                    :: 1, 1 (5S, 16S)
            partial rRNAs                     :: 1 (16S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 300
            CDSs (without protein)            :: 300
            Pseudo Genes (ambiguous residues) :: 0 of 300
            Pseudo Genes (frameshifted)       :: 123 of 300
            Pseudo Genes (incomplete)         :: 254 of 300
            Pseudo Genes (internal stop)      :: 20 of 300
            Pseudo Genes (multiple problems)  :: 87 of 300
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:59:12
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 44626
            Orig. end                         :: 54830
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CAKMXI010000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10204
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10204
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10204
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5204](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5204
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            427..3006
                     /locus_tag="NBY68_RS04085"
     CDS             427..3006
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015611077.1"
                     /locus_tag="NBY68_RS04085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="discoidin domain-containing protein"
                     /protein_id="WP_250287610.1"
                     /transl_table=11
                     /translation="MSLTRISLLAPLIAGTLIAPLPPLSHAAGPAPVCGSTGTPSGTSW
                     APTSTTFGEAGGYDPYVGNGYLGHRVPATGAGYAATGGRTGWPLYTPRYDGAFVSGLYS
                     RDESLAEGREVIAALPSWTTLDVRVGSETYGSATPAGRISRYRQTLHLRCGVVVTSLRW
                     TTADGRATDLVYEVLADRSDAHTGAVRLRMTPHWSGTATVTGRLDERGARRVTVAGDGT
                     FRTLGTGTEGAVVQRGTDGARTATVRAGRSYTFEKYVGVDTSLTSRTPLASATAAADRA
                     ARRGWSGVLAGNAAAWREAWASDVRVPGSADLQAWLRAAQYGLLANTRPGSSDSIAPAG
                     LTSDNYAGMVFWDAETWMYPGLLATRPELARSVVEYRYRTRDAARANAGKLGHAGLFYP
                     WTSASKGRLDSECQSWDPPHCLTQIHLQGDVSLAVWQYYLATGDRAWLAGRGWPLLKGI
                     ADFWESRATANADGSYSVKDVAGPDEYSNGVTDGVFTNAVAATALRNATRAAGLLGHPA
                     PAGWTRVADGLRIPYDAERKLYLQYAGYNGSTIKQADTVLLVYPLEWPMAEGAAAATLD
                     HYAARTDPDGPAMTDSVHAIDAAAIGGPGCATYTYLQRAVRPFVRGPYDLFSEARGEKS
                     GAQDPLSGFPAEDFLTGKGGFLQVFTHGLTGLRLREDGVRLDPLLPPQLREGVELTGLR
                     YRGRTYDITIGPRTTSVRLTDGEPFTVHTPEGPRRLSGTLTLPTRRPDLTPTPDAARCR
                     PATATSEAPGLYAEAAVDGSPSTSWSPDGAAGTLTVTLRQVTRIASIAPRWADTAPASH
                     TLETSLDGRTWRPYEPGDVARQVRLTVRSADAEKPTGVTALTVVAGA"
     gene            3152..3967
                     /locus_tag="NBY68_RS04090"
     CDS             3152..3967
                     /NRPS_PKS="Domain: Abhydrolase_1 (22-247). E-value:
                     9.5e-30. Score: 95.9. Matches aSDomain:
                     nrpspksdomains_NBY68_RS04090_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018105916.1"
                     /locus_tag="NBY68_RS04090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_250287611.1"
                     /sec_met_domain="PF00561 (E-value: 1.3e-23, bitscore: 79.4,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 3.2e-23, bitscore:
                     79.0, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTMANGVSIRYDDQGPSDGIPVVLVHGHPFDHTLWAPQVTALT
                     AAGYRVVTPDLRGYGGSEVVPGACLLSDHADDIAALLDTIGLDRVVVGGVSMGGQITME
                     FQRTHPERVRALVLSDTSPVAETDEGKAFRNALADRLLAEGMGGYADEVIDKMIAPYNV
                     TALPDVAEHVLAMMRATAPEGAAAALRGRAERPDYRDTLARTSVPVLVVVGADDFYTPV
                     SDARATHSLIPSAELVVIEQAGHLPGAEQPAAFNDALLAFLRTRVAVHG"
     misc_feature    complement(3171..3189)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.97"
                     /tool="antismash"
     aSDomain        3218..3892
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NBY68_RS04090_Abhydrolase_1.1"
                     /evalue="9.50E-30"
                     /label="NBY68_RS04090_Abhydrolase_1.1"
                     /locus_tag="NBY68_RS04090"
                     /protein_end="247"
                     /protein_start="22"
                     /score="95.9"
                     /tool="antismash"
                     /translation="PVVLVHGHPFDHTLWAPQVTALTAAGYRVVTPDLRGYGGSEVVPG
                     ACLLSDHADDIAALLDTIGLDRVVVGGVSMGGQITMEFQRTHPERVRALVLSDTSPVAE
                     TDEGKAFRNALADRLLAEGMGGYADEVIDKMIAPYNVTALPDVAEHVLAMMRATAPEGA
                     AAALRGRAERPDYRDTLARTSVPVLVVVGADDFYTPVSDARATHSLIPSAELVVIEQAG
                     HLP"
     gene            <4188..4366
                     /locus_tag="NBY68_RS04095"
                     /pseudo=""
     CDS             <4188..4366
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018105646.1"
                     /locus_tag="NBY68_RS04095"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="DoxX family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="AGFAVPLLGTLAAACLVLYFIGAIIAHLRVGSRDIVGGIRS"
     misc_feature    complement(4783..4798)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.76"
                     /tool="antismash"
     gene            5001..5204
                     /locus_tag="NBY68_RS04100"
     CDS             5001..5204
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153869.1"
                     /locus_tag="NBY68_RS04100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_033298013.1"
                     /sec_met_domain="strepbact (E-value: 2.9e-18, bitscore:
                     61.7, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSAPQIQTQEITDADLDNVSGGVFAGLAGEVSLDTPLSSLSAGL
                     SGAVGADGLGVAGLGTASTLSA"
     gene            5321..6388
                     /locus_tag="NBY68_RS04105"
     CDS             5321..6388
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010987305.1"
                     /locus_tag="NBY68_RS04105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_250287612.1"
                     /transl_table=11
                     /translation="MTDHPHTTRRPTGPGNRWELVWSHRDELLEIARRRSSSAEEAEDA
                     VQVAMLRAVEDKDVQYGRVRSWLRHATVRACDERHRQLARDAELSTSPSTAPAEPLPVE
                     EAACDRAEARWLADLSDELLPARQAEALRLRSQDLDVTQVARAMGLSYRATESLLARAR
                     RSLRDVLAGSFVLATLVWTFVRKFPRTGTTRSAVAASAAVTAATVGLSLPAVPPDRPDG
                     HPPRADAGALRPAPTTDFSTPRPAPERPRAPSPSPAPDRVARVTRDTPQPDPGNPEGNH
                     EPGAAAAVEIRIGSVALAAGLPSASTPTSIPPLPVETPHASFTQAPSAPSRILTETATA
                     LSHLPRTNHRGALPP"
     gene            6468..6884
                     /locus_tag="NBY68_RS04110"
                     /pseudo=""
     CDS             6468..6884
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007494681.1"
                     /locus_tag="NBY68_RS04110"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="DNA-binding protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKGPAARSLVLGSQALSLLLRNDRQMVTRIEAARRIGVPVLASAL
                     TVVEAVYGKTDTARLH"
     gene            complement(7123..8436)
                     /locus_tag="NBY68_RS04115"
     CDS             complement(7123..8436)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020139694.1"
                     /locus_tag="NBY68_RS04115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="replication-associated recombination protein A"
                     /protein_id="WP_250287613.1"
                     /transl_table=11
                     /translation="MEPTGATLPLFDEEPARPLADRLRPTRLEDVVGQDHLLAPDAPLG
                     RMVASQRLGSAILWGPPGVGKTTIARLLADGSNLAFEPVSATFSGVAELRKVFAAARSR
                     RTIGQGTLLFVDEIHRFNRAQQDSFLPYVEDGTITLIGATTENPSFELNGALLSRTQVL
                     VLKRLDEAALSTLLDRAEDLTGHRLPLDDDARRALIAMTDGDGRYLLNMAEQLQALPHP
                     GTPLDTAALAHHIQQRAPLYDKAQEGHYNLISALHKSMRGSDPDAALYWLARMLDGGED
                     PLFVARRLVRFASEDIGIADPHAIQQALAAWDVYERLGSPEGELAIAQAVVYLATAPKS
                     IAVYRGFNAAHRSARRTGSLMPPAHILNAPTRLMKDIGYGKDYQYDPDTTDGFSGADYF
                     PDGMDHETYYQPTRNGYESQISERLRHWTGLRARRRSG"
     gene            complement(8537..8905)
                     /locus_tag="NBY68_RS04120"
     CDS             complement(8537..8905)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1198: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020139693.1"
                     /locus_tag="NBY68_RS04120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MmcQ/YjbR family DNA-binding protein"
                     /protein_id="WP_250287614.1"
                     /transl_table=11
                     /translation="MSAAGSRLQDTARQTALALPGTDHGYPFTKHLDVYKVAGKVFLIV
                     TDDPDEQIITVKCEPEHARAHVHDYASITPGRYLDKRHWISLGPGPGITERLVTGAVED
                     SYDLAVARLPGRDRPRTR"
     gene            complement(8902..9297)
                     /locus_tag="NBY68_RS04125"
     CDS             complement(8902..9297)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1198: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007383608.1"
                     /locus_tag="NBY68_RS04125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MmcQ/YjbR family DNA-binding protein"
                     /protein_id="WP_250287615.1"
                     /transl_table=11
                     /translation="MNGTTLHKTAADRAEELPGAQLEHPFGDDWEVFKVRGKVFMLMTE
                     VPGRPVVILKADPGEAHALREQYSHITPGYHMNKRHWITLESGEGVDKELVDELVTDSY
                     RLVVAHLPKAERPIDPHTYGRRTRAAR"
ORIGIN
        1 tcgttgcgga acgcgtgcag gccgccttgg ggcacgtaca ggaagtcacc cggcgtggcg
       61 tcggtccacc gttcgccgtc gtagatccgc accgtcccgt cgaggatgaa gaacgactcc
      121 gagatggacc ggtggaagtg ctcggccggc ccgcccgccc tggggcccat gttgatccgg
      181 tacagcccga actcgccgtg ggtcgactcc gtcgtggcca ggtagtgggt gctgcctccg
      241 ctgcggggca ggaagttcgg ggtggtgccg gccggccggt actgcgcgtt gatctcgccc
      301 gcgccgcccg tgtagacggg ttccggatac gacatgccgc tctccctgcc tccggccccg
      361 gggccggtcc gctcgtcccg cgcgccggta ccgcaccggc ggcgtcgtct tccctacctt
      421 cgtacggtga gcctcacgcg catctctctc ctcgcgcccc tgatcgcggg cacgctgatc
      481 gcccccctgc caccgctatc ccacgccgcc ggccccgccc ccgtgtgcgg cagcaccggc
      541 acgccctccg gcacctcgtg ggcgcccacg tccaccacct tcggcgaggc cgggggatac
      601 gacccgtacg tcggcaacgg ctacctgggt caccgcgtcc ccgccacggg cgccggatac
      661 gccgccacgg gcggcaggac gggctggccc ctctacaccc cacggtacga cggtgccttc
      721 gtctccgggc tctactcccg tgacgagagc ctcgccgagg gccgcgaggt gatcgcagcg
      781 ctcccgtcct ggaccacgct cgacgtacgc gtcggttccg agacgtacgg ctccgccacc
      841 cccgcaggcc gcatctcgcg ctaccgccag accctccacc tgcgctgcgg cgtcgtggtc
      901 acctccctgc ggtggaccac ggccgacggc cgcgcgaccg acctggtcta cgaggtgctg
      961 gccgaccgct ccgacgcgca caccggcgcc gtacgcctgc ggatgactcc gcactggagc
     1021 ggcaccgcga cggtgacggg ccggctggac gagcgcgggg cgcgccgggt cacggtcgcc
     1081 ggtgacggca cgttccgcac actcggcacg ggcacggagg gggcggtcgt ccagcggggc
     1141 accgacggcg cccgcacggc gacggtcagg gcgggccgtt cgtacacctt cgagaagtac
     1201 gtcggcgtcg acacctcgct cacctcccgc accccgctcg cctccgccac ggcggcggcg
     1261 gacagggcgg cccggcgcgg ctggtccggg gttctcgccg gcaacgcggc ggcctggcgt
     1321 gaggcctggg cgtccgacgt ccgggtaccc ggcagcgcgg acctgcaggc ctggctgcga
     1381 gcggcgcagt acgggctgct ggccaacacc cggcccggtt cctcggacag catcgccccg
     1441 gccggtctga ccagcgacaa ctacgcgggc atggtgttct gggacgccga gacctggatg
     1501 tatccggggc tgctggccac ccgccccgaa ctggcccgct ccgtcgtcga gtaccgctac
     1561 cgcacccggg acgccgcccg cgccaacgcc gggaaactgg gccacgcagg gctgttctac
     1621 ccctggacga gcgcgagcaa ggggcggctg gactccgagt gccagagctg ggacccgccg
     1681 cactgcctca cccagatcca tctccagggc gatgtctcgc tcgccgtctg gcagtactac
     1741 ctggccaccg gtgaccgcgc ctggctggcc ggccggggct ggccactgct gaaggggatc
     1801 gccgacttct gggaatcgcg ggccacggcg aacgccgacg gcagttactc ggtgaaggac
     1861 gtcgcgggcc ccgacgagta cagcaacggg gtcacggacg gcgtcttcac caacgcggtc
     1921 gccgccaccg ccctgcgcaa cgccacccgt gccgccggcc tcctcggcca cccggcgccc
     1981 gccggctgga cccgggtcgc cgacgggctg cgcatcccct acgacgccga gcggaagctg
     2041 tacctccagt acgccggata caacggctcg acgatcaagc aggccgacac ggtgctgctc
     2101 gtctacccgc tggagtggcc gatggcggaa ggagccgccg ccgcgacgct cgaccactac
     2161 gccgcccgca ccgacccgga cggccccgcg atgaccgact cggtgcacgc gatcgacgcc
     2221 gccgcgatcg gggggccggg ctgcgccacg tacacctacc tccagcgcgc cgtgcgcccg
     2281 ttcgtccgcg gtccgtacga cctcttctcc gaggcgcggg gcgagaagtc cggcgcgcag
     2341 gacccgctct cgggcttccc cgccgaggac ttcctcaccg gcaagggcgg cttcctccag
     2401 gtcttcacgc acggcctcac gggactcagg ctgcgcgagg acggcgtacg cctcgacccg
     2461 ctcctgcccc cgcagctccg cgagggcgtg gagctgacgg ggctgcgcta ccggggccgt
     2521 acgtacgaca tcaccatcgg ccccaggacg acctcggtcc ggctgacgga cggcgagccc
     2581 ttcaccgtcc acaccccgga gggcccgcgc cgcctctccg gcaccctcac gcttcccacg
     2641 cgtcgccccg atctcacgcc gacgcccgac gccgcccgct gccgccccgc gacggccacc
     2701 tccgaggccc ccggcctgta cgccgaggcg gcggtggacg gcagcccgtc gacctcctgg
     2761 tcgccggacg gagcggcggg cacgctgacg gtgacgctgc gccaggtgac ccggatcgcg
     2821 tcgatcgcac cccgctgggc ggacaccgca ccggcctccc acaccctgga gacctccctg
     2881 gacggccgca cctggcgtcc gtacgaacca ggcgacgtgg cccgccaggt caggctgacg
     2941 gtccgctccg cggacgctga gaaaccgacg ggggtgaccg cgctgaccgt cgtcgccggc
     3001 gcataggcgg ccgcgggacc ggagacggcg gcccggacca ccgaactcac cggcgccctc
     3061 accgggcgcc ggtgcgggcg cgcgcacgtg cggccgtccc gcatggccga aaactcgagg
     3121 cgtcagcggt gggcggcgtt acagtgccgt catgatcagg acaatggcca acggtgtgtc
     3181 catccggtac gacgatcagg ggccgtcgga cggcataccc gtggtgctcg tgcacggcca
     3241 tccgttcgac cacaccctgt gggcccctca ggtcaccgca ctcacggcgg ccgggtaccg
     3301 ggtcgtgaca ccggacctcc gcggctacgg cggcagcgaa gtcgtaccgg gggcctgtct
     3361 cctctccgac cacgccgacg acatcgccgc actcctcgac acgatcggcc tggacagggt
     3421 ggtcgtcggc ggtgtctcca tgggcggcca gatcaccatg gagttccagc gcacccaccc
     3481 ggagcgggtc cgcgcgctcg tcctgtcgga cacctccccg gtcgccgaga ccgacgaggg
     3541 caaggccttc cgcaacgccc tcgccgaccg gctcctcgcc gaaggcatgg gcggctacgc
     3601 ggacgaggtc atcgacaaga tgatcgcccc gtacaacgtc acggcccttc ccgacgtcgc
     3661 cgagcacgtc ctggccatga tgcgcgccac cgccccggag ggggccgcag ccgcgctgcg
     3721 cggacgggcc gagcggcccg actaccgtga caccctcgcc aggacctcgg tgccggtcct
     3781 cgtcgtggtc ggcgccgacg acttctacac cccggtgagc gacgcccggg ccacgcacag
     3841 cctgatcccg tccgccgagc tcgtcgtcat cgagcaggca gggcacctcc ccggtgccga
     3901 acagcccgcg gccttcaacg acgcgctcct ggccttcctc cggacgaggg tggccgtcca
     3961 cggctgagtg gcgccgcccc tcgccctcac cgtccgcagc ggtggggggc gccgtcggcc
     4021 gtgtgccgac gtcctgagtc aatttcccgc cactccgcag gtcccggacc gaaggctcac
     4081 acctcgaact agtgacacgg cggcgcggag tgcgggccgt tctcgccgat cggcccgaac
     4141 ggcccgatca acacctgctc acgccaggct ggtttctccc ggcccgcgca gggttcgccg
     4201 tgccgctgct gggaaccctc gccgccgcgt gcctcgtgct gtacttcatc ggcgcgatca
     4261 tcgcccacct gcgcgtgggc tcccgcgaca tcgtgggcgg tatccgttcc tgatcaccgc
     4321 ggcggccgcc ctcgtcctgg gcgtgctgca ccgcggcgcc tggtgacact cgcggtcggc
     4381 cgggctccgc ggccggccgg gctgccactc ccgtaccaat tccggcggac gcgtgacggg
     4441 tattcccacg cccggcgcga tggacggcga ctccggccct ccggccgatg agcaccacga
     4501 cgcggagccg gggcgcgagg ccgaggacgg gcgggcccgg tactccggtc ccgccgggta
     4561 cgcgaggtcg tggtccggcg ggcccggtat tccggtcccg gtctcccccg cggggcgccg
     4621 gaccctgctg tctgcggcgg atctccacaa ggcgcacgca ggtgccccgt cacctgcgac
     4681 gaccccccat gtgcggagcg gacccctcgt gcccgtcacg cagaatgtcc cgttcgcggc
     4741 ggagtaaaga tctggccggc gcgacgtccg tcggccgctc aggtgaagaa aacgtaccgg
     4801 tccacgaacc gatgtgaccg caccggctct tcgatgggga aatgcacggt gaggggccgt
     4861 cgggcgggtg gcctcgccac gcgcccacgt gctttcatcc ttcacgtcgc ggaggccccg
     4921 accgcgacaa cggcgaggcc gctccgtcct gacggagtcg gcctcggccg tccgtgatca
     4981 gcgtgaaagg aattcacctc atgagctccg ccccccagat acagacccag gaaatcaccg
     5041 acgcggacct ggacaacgtg tccggtggcg tcttcgccgg cctggcaggc gaggtctccc
     5101 tcgacacgcc gctctcctcg ctctccgccg ggttgtcggg cgccgtcggc gccgacgggc
     5161 tgggtgtcgc cgggctcggg accgcctcca cgctctcggc ctgacccgac gccgtacccg
     5221 tatgcccccg atgccggaca ggtcgtgggg cataggggcc gtggggcgcc atgatcagcg
     5281 cacgacggag cccgagacca cagtccgggg agcctaaaac gtgacggacc acccacacac
     5341 gactcgtcgg ccgaccggcc cgggcaaccg gtgggagctc gtctggagcc accgggacga
     5401 gctgctcgag atcgcacgcc gccgttcgtc gagcgccgaa gaggccgagg acgccgtcca
     5461 ggtagcgatg ctccgcgcgg tggaggacaa ggacgtccag tacggccggg tgcgctcatg
     5521 gctcaggcac gcgaccgtac gcgcgtgcga cgaacggcac cgtcagctcg cccgcgacgc
     5581 ggagttgagc acgagccctt ccactgctcc cgccgagccc cttcccgtcg aggaagcggc
     5641 atgcgaccgg gcagaggccc ggtggctggc agacctcagc gacgaactgc tgcccgcccg
     5701 ccaggcggag gcactgcggc tccggtccca ggacctcgac gtcacacagg tcgcccgggc
     5761 catggggctg agctaccggg cgaccgagtc cctgctcgcc agggccagaa ggtcgttgcg
     5821 tgacgtcctg gccgggagct tcgtcctggc cacgctcgtc tggacgttcg tacgcaagtt
     5881 cccgcgcacg gggaccaccc ggtcagcagt ggcggcctcg gccgcggtca ccgcagccac
     5941 agtgggactg tccctgcccg ccgttccccc cgaccggccg gacggccacc ctccgagggc
     6001 cgacgccggt gcgctgcgcc ccgccccaac cacggacttc tccactcccc gcccggctcc
     6061 ggaacgtccg cgggcaccgt ccccctcccc ggccccggac cgcgtcgccc gggtgacccg
     6121 ggacaccccc cagcccgatc cgggaaaccc ggaggggaac cacgagccgg gggccgcggc
     6181 agcggtggag atacggatcg gatccgtcgc actggcagcg ggactgccgt cggcgtccac
     6241 gcccacgtcg ataccgcccc tgcccgtgga aacgccccac gcctccttca cgcaggcgcc
     6301 ctcggcaccg tcccgcatcc tgaccgagac ggcgaccgca ctttcacatc tgccgcgtac
     6361 gaaccacagg ggcgctctcc caccctgagc gaggccgaag tccgggccgc gcagagcgaa
     6421 ctgttcggtg atgcacccgc gccctacgcg tcgaacgaca gcgccgcgtg aaggggcccg
     6481 cggcccggtc cctggtgctc ggctcccagg cgctgtcgct cctcctgcgc aacgaccgcc
     6541 agatggtcac ccggatcgag gccgctcggc gcataggcgt gcccgtcctc gcatcggccc
     6601 tgacggtggt ggaggccgtc tacgggaaga cggacaccgc ccggctgcac tgactgctct
     6661 cccgcctcca ggtccaggac gtcacccagg cggacagcct caccgccgtg cagctactga
     6721 gcgatgccgg tggcctgcac ggccacaagt acgccatcga cgccctcgtc gccctcgtcg
     6781 ccgcgatggc actccgctcc ccggcgcccg tcctcgtact gacctcggac cgcgacgact
     6841 gggccgaatt gtgcggcgac cgcgttcaga tcaaggacgt ctgaccttgg gatttacccc
     6901 ttccaacgaa gacgactcgc gacccgagaa cggctaacgc cgatgtcagt aacatcggcg
     6961 ttagtcccat gcgtagggaa tccacttcgc cagctgtccc tcacggtcgc gagtcgtgga
     7021 tccgcacatc tccggaccgc gcggcatcga atgcgcggat cgcacgacga ctcatcaccc
     7081 ttctgccgtg tgcgggctct gtccgctgcc catacgtcca cgtcagccgc tgcgcctacg
     7141 agcgcgcaag ccggtccagt ggcgcaggcg ctcggatatc tgggactcgt agccgttgcg
     7201 ggtgggctgg tagtaagtct cgtggtccat gccgtcgggg aagtagtcag cgccggagaa
     7261 gccgtcggtg gtgtcggggt cgtactggta gtccttgccg tagccgatgt ccttcatcag
     7321 ccgggtcggg gcgttgagga tgtgggcggg cggcatgagt gagccggtgc ggcgagcgga
     7381 tcggtgggcc gcattgaagc cgcggtagac ggcgatggac ttgggggccg tggcgaggta
     7441 cacgacggcc tgcgcgatcg ccaactcacc ctcgggggag ccgagtcgct cgtacacgtc
     7501 ccaggcggcg agtgcctgct ggatggcgtg cgggtcggcg atgccgatgt cctcgctcgc
     7561 gaagcggacc aggcggcggg ccacgaacag ggggtcctcg ccgccgtcga gcatgcgggc
     7621 gagccagtac aaggccgcgt ccgggtcgga gccacgcatc gacttgtgga gcgcggagat
     7681 caggttgtag tggccctcct gtgccttgtc gtacagcggg gcgcgctgct ggatgtggtg
     7741 ggcgagcgcg gcggtgtcca ggggggtgcc ggggtgcggg agggcctgga gctgttcggc
     7801 catgttgagg aggtagcggc cgtcgccgtc ggtcatggcg atcagggcgc ggcgggcgtc
     7861 gtcatccagg ggcagccggt ggccagtgag gtcctcggcg cggtcgagga gtgtggacag
     7921 ggcggcttcg tccaggcgtt tgaggacgag gacctgggtg cgggagagga gggcgccgtt
     7981 gagttcgaag ctggggtttt ccgtggtggc gccgatcagg gtgatcgtgc cgtcctcgac
     8041 gtagggcagg aagctgtcct gctgggcgcg gttgaagcgg tggatctcgt cgacgaacag
     8101 cagggtgccc tggccgatgg tgcgccggct gcgggcggcg gcgaagacct tgcgcagctc
     8161 cgccacgccg gagaaggtgg ccgacaccgg ttcgaaggcc aggttgctgc cgtccgcgag
     8221 gaggcgggcg atggtcgttt tccccacgcc gggcgggccc cacaggatgg cggagccgag
     8281 gcgctgcgac gcgaccatgc ggcccagcgg ggcgtccggg gccaggaggt ggtcctgccc
     8341 gacgacgtct tccagtcggg tgggacgcag ccggtcggcg agtggccggg cgggctcctc
     8401 gtcgaagagc ggcagggtcg ctccggtcgg ttccatcggt ctctcagatt gcgggcgggg
     8461 ctgtgcgggc gtggcgagcc ttgcacgggg cactgacaag cgccagctca gcggctcgtg
     8521 cgcgcgcttg cggtgctcat cgggtacggg ggcggtcgcg cccgggcagc cgcgcgacgg
     8581 ccaggtcgta ggaatcctcg actgcgccgg tgaccagccg ctcggtgatg ccggggcctg
     8641 gcccgagcga gatccagtgc cgtttgtcga ggtagcgacc cggtgtgatc gaggcatagt
     8701 catgcacatg cgcgcgggcg tgttcgggtt cgcacttgac cgtgatgatc tgctcgtccg
     8761 ggtcgtcggt gacgatcagg aacaccttgc ccgcgacctt gtacacgtcc aggtgcttgg
     8821 tgaacggata gccgtggtcc gtcccgggca gcgcgagcgc cgtctggcgg gcggtgtcct
     8881 ggagccggct gccggccgcg ctcaccgggc tgcccgcgtg cggcggccgt aggtgtgggg
     8941 gtcgatgggc cgctcggcct tgggcaggtg tgcgacgacg agccggtagg agtcggtgac
     9001 gagttcatcg acgagttcct tgtcgacgcc ttctccgctc tccagggtga tccagtgcct
     9061 tttgttcatg tggtagccgg gggtgatgtg gctgtactgc tcccgcaggg cgtgggcttc
     9121 gccggggtct gccttgagga tcacgacggg tcgccccggg acctcggtca tcagcatgaa
     9181 caccttgccg cgcaccttga agacctccca gtcgtcgccg aagggatgct ccagctgggc
     9241 tccgggaagc tcctctgcgc ggtcggcggc ggtcttgtgc agggtcgttc cgttcatggg
     9301 cgttgccttc ctcacggggt ggtcgcggcg gcacacccca ttcttccttc gaagccgaca
     9361 aatagggcgg tagactgcgg acacgtgatg gtcgacaggc gacaccccag cccgagcgga
     9421 caggccggac cggccacggt cccgctgtac ggcttccagc ccccgatcgg caccccgtac
     9481 ggccttgaag tgagcaccgt cgaggaattc ttcgcccagc acgacgactg gccgtggaac
     9541 ccgccccgtc cgggccgcgc caccttccac tacctcatcg ccgtcaccga gggcgagttg
     9601 cggcacgacg tcgaccacct cacgcggacc gtcagccccg gccagtggct gtgggtgcgt
     9661 cccgggcacg cgcagtgctg gcatccgccc ggcgccgccc gcggcccgtt catcctgttc
     9721 gaaccggatg tactgcggcc cgacatcgcc cgcctgctcg ccccgctcac cgcacacgcg
     9781 gctcctgccg tactgagccc gcaccccgac gacgccgcct ggctccagca gacggcactc
     9841 cagcttctgg acgaacaccg cgcactcggg cgccgacccc tcgacgtcca ccacgccctg
     9901 cggcgcagcc tgctcgaatc actgctgcta cgcctcgcag gcgcccccgg gatcaccccc
     9961 gccgacacga gtgccggcag aagccgtggt gacacctacg gacggttcgc ggacgccctg
    10021 gagctgcact tccgcgagct gcaccgggcc gcggattacg cagagctaat cggctgctcg
    10081 gtccgcaccc tcagccgcgc cgcccgggaa accaccggca agggggtacg tgaactcatc
    10141 gacgaacggc gcctgctcga agcccggcgc ctactgggag gtgcccgatg ggatgcccgg
    10201 tccg
//
