LOCUS       NZ_CABVIY010000004     10855 bp    DNA     linear   CON 07-NOV-2023
DEFINITION  Pseudomonas fluorescens isolate PS918, whole genome shotgun
            sequence.
ACCESSION   NZ_CABVIY010000004
VERSION     NZ_CABVIY010000004.1
KEYWORDS    WGS; RefSeq.
SOURCE      Pseudomonas fluorescens
  ORGANISM  Pseudomonas fluorescens
            Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
            Pseudomonadaceae; Pseudomonas.
REFERENCE   1
  AUTHORS   Chandra,G. and Truman W,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2019) JOHN INNES CENTRE, NORWICH, UK., Molecular
            Microbiology, Norwich Research Park, Norwich NR4 7UH, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/07/2023 08:57:44
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,059
            CDSs (total)                      :: 5,986
            Genes (coding)                    :: 5,920
            CDSs (with protein)               :: 5,920
            Genes (RNA)                       :: 73
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1, 1 (16S, 23S)
            tRNAs                             :: 63
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 66
            CDSs (without protein)            :: 66
            Pseudo Genes (ambiguous residues) :: 0 of 66
            Pseudo Genes (frameshifted)       :: 7 of 66
            Pseudo Genes (incomplete)         :: 63 of 66
            Pseudo Genes (internal stop)      :: 6 of 66
            Pseudo Genes (multiple problems)  :: 8 of 66
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 15:35:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 492936
            Orig. end                         :: 503791
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CABVIY010000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10855
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10855
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10855
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5855](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5855
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            1..903
                     /locus_tag="F8N66_RS17480"
                     /old_locus_tag="PS918_03330"
     CDS             1..903
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007948747.1"
                     /locus_tag="F8N66_RS17480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PS918_03330"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_150771364.1"
                     /transl_table=11
                     /translation="MTVKQIRAFLAVAQSLSFAVACERLHLSQSALSLTIKALEEGLGG
                     RLFTRNTRNVALTAEGESLVPLARRLIADWDNAEDELRQRFTLQRGRVTLAAMPSFAGN
                     LLPPILKTFRARYPKVNVTVNDVINEQVLEMVRDRQVELGVAFEPTQNSSLQFTPLYID
                     RFVAVVPHDSALVERDHIDWQTLLMEPFITLQRPSTVRVMLEEHLQARGMKLPVEFESH
                     QLATVGRMVASGLGVSAVPALCAGQMRELGAHCITLSDPVVERAIGVLTLPGGELSAAA
                     QALFDVLKEENFGQQLSSR"
     gene            complement(1022..1864)
                     /locus_tag="F8N66_RS17485"
                     /old_locus_tag="PS918_03331"
     CDS             complement(1022..1864)
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008043308.1"
                     /locus_tag="F8N66_RS17485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PS918_03331"
                     /product="NAD-dependent protein deacetylase"
                     /protein_id="WP_150771365.1"
                     /transl_table=11
                     /translation="MIDSLIHEQLDRLRQLMADEPFAVLTGAGISTPSGIPDYRDHQGV
                     RRGRQPMMYQEFLSAPESRRRYWARAMLGWPRVRHAMPNVAHDTLAHLQSTRLIGGLIT
                     QNVDTLHDQAGSHDVIELHGSLHRVLCLDCGQRCERDAIQQVMETQNPYLAGVDAVQAP
                     DGDTLLDSAFEARFQVPHCPHCTGERMKPDVVFFGENVAQETAAKAMATVEKAAGLLVV
                     GSSLMAYSAFRLCRSVVDQGKPLIAINLGKTRADELLDLKIEGSCEQLLPLLAQRLSL"
     gene            complement(1981..3027)
                     /locus_tag="F8N66_RS17490"
                     /old_locus_tag="PS918_03332"
     CDS             complement(1981..3027)
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (164-270). E-value: 1.5e-12. Score:
                     38.2. Matches aSDomain: nrpspksdomains_F8N66_RS17490_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042: O-methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019582146.1"
                     /locus_tag="F8N66_RS17490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PS918_03332"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_150771366.1"
                     /transl_table=11
                     /translation="MDEARLNDFMGKLVNDMGGAAMLANVILGEELGLYRAMADSQLIS
                     PEALAEKTGCNARLVREWLSAHAASGYMEHSGGQFRLPEEQALALAIEDSPVYIAGGIG
                     VVASFFHDKDKLVKAMRGDGALPWGDHHPCMFSGTERFFRPGYKAHLIAEWLPALDGVV
                     AKLEAGAKVADIGCGHGASTVIMAQAFPDSRFVGFDYHAPSVTVATQRAEEGGVSGRAR
                     FFQGTAKSYPGDDYDLVCYFDCLHDMGDPEGAAKHAYDSLKPDGTVLLVEPFANDSLDD
                     NITPVGRLFYAASTFICTPNSLSQEVGLGLGAQAGEARLRKVFSEAGFSSFRRATETPF
                     NLILEARK"
     aSDomain        complement(2218..2535)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_F8N66_RS17490_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="1.50E-12"
                     /label="F8N66_RS17490_oMT.1"
                     /locus_tag="F8N66_RS17490"
                     /protein_end="270"
                     /protein_start="164"
                     /score="38.2"
                     /tool="antismash"
                     /translation="KLEAGAKVADIGCGHGASTVIMAQAFPDSRFVGFDYHAPSVTVAT
                     QRAEEGGVSGRARFFQGTAKSYPGDDYDLVCYFDCLHDMGDPEGAAKHAYDSLKPDGTV
                     LL"
     misc_feature    3404..3419
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.15"
                     /tool="antismash"
     gene            3522..4856
                     /locus_tag="F8N66_RS17500"
                     /old_locus_tag="PS918_03333"
     CDS             3522..4856
                     /GO_function="GO:0016811 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds, in linear amides
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010455516.1"
                     /locus_tag="F8N66_RS17500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PS918_03333"
                     /product="acetamidase/formamidase family protein"
                     /protein_id="WP_150771367.1"
                     /transl_table=11
                     /translation="MTTLVPESTLDTTPVDRLRVDHYTNGIIGPSQPMLGPLADGGTLI
                     TGTPPGCWGPMITPAFEGGHEVTQPVYVAGAEIGDAVAIKIQSMRVTSLATSSGVMSFV
                     EGRYNGDPFVAKFCSKCGTEHPASHVEGIGEDAIRCNHCGAEVSAFRFSHGYVIVFDAQ
                     NQVSLTVNQDIANQLAGKASEMSALPEFAAQHSILSLARADIPGVAAHMRPFLGNIGTM
                     PSRDLPDSHNCADFGQYLINAPHRFGMTREELHAAKTDGHMDTNSIREGCVLICPVKVP
                     GAGVYMGDMHAQQGNGEIAGHATDCSGETEVVVEVVKNLTLEGPILLQNLDDLPPMARP
                     MNAGQRANVRALGERWGQHEIEQSGPITFLGSGENLNLAVENGLQRAANATGLPYDEVL
                     NRATITGSIDISRLPGTVRVTFLCPMPVLDRMGIGHLVREKYDLA"
     misc_feature    4946..4966
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 22.21"
                     /tool="antismash"
     gene            5001..5855
                     /locus_tag="F8N66_RS17505"
                     /old_locus_tag="PS918_03334"
     CDS             5001..5855
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007990964.1"
                     /locus_tag="F8N66_RS17505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PS918_03334"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_150771368.1"
                     /sec_met_domain="DUF692 (E-value: 1.8e-118, bitscore:
                     390.0, seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQTPITYARASAGLGLRRGLMKDLLAAPAGHFDFLEVAPENWIGI
                     GGAHGAALRTLAERYPLSCHGLSLSLGGPSPLDVGFLQEVRVFLDHYNVPLYSEHLSYC
                     SDDGHLYDLLPLPFTEEAVHHVAARIRQAQDILGRRLAVENVSYYAAPQQDMDEVTFTN
                     AVLREADCDLLLDVNNVYVNSINHGFDPRTFLAGIDANRVVAMHIAGHFDESDTLKIDT
                     HGASVKPAVWSLLAQAYARFGAQPTLLERDFNFPLFSELVAELQTIRRLQTEEVNRGQA
                     LVV"
     gene            5833..6591
                     /locus_tag="F8N66_RS17510"
                     /old_locus_tag="PS918_03335"
     CDS             5833..6591
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017338023.1"
                     /locus_tag="F8N66_RS17510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PS918_03335"
                     /product="putative DNA-binding domain-containing protein"
                     /protein_id="WP_150771369.1"
                     /transl_table=11
                     /translation="MAKRSLFDQQSSMGLYLRDPEHCAPPPEMDPKRARVYRDLVFANL
                     SSLISGTFPVLVQILGDSQWRALVRIFLRDYRAHTPKFGEIAEEFVEFLTSEPPALADG
                     TWPPFMVELAHYEWVEMALQQSEAEPLSPGDADLLPERPLQVSPLAWPLAYAWPVQSVG
                     PDYQPATVPAEPTLLLVRRADDWSVKFSALTPLAWRLLQRIDEFPELSGRAQLQALAVE
                     AGQGGSQEFFDSGLALLRQLHEEEVVGVIS"
     misc_feature    6770..6784
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.04"
                     /tool="antismash"
     gene            6941..8566
                     /locus_tag="F8N66_RS17520"
                     /old_locus_tag="PS918_03336"
     CDS             6941..8566
                     /GO_process="GO:0006935 - chemotaxis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1061: methyl-accepting
                     chemotaxis protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003224646.1"
                     /locus_tag="F8N66_RS17520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PS918_03336"
                     /product="methyl-accepting chemotaxis protein"
                     /protein_id="WP_150771370.1"
                     /transl_table=11
                     /translation="MSLRNLNIAPRAFLGFAFIALLVIVLGVFAVNRMSIIRQSSIDMG
                     STQLPSVGYLGNITENILRMRILSFRILVNREPGSLQEAQTRIGVLTDNARKAQASYAE
                     LPAGPDEAALYKAFSATLDNYMQAQREMLDLSRQNKVDEMRTLINTRIKDGTDQMGEQL
                     SRLVKYNTDGAKAAGVIAENNYNAAVNGIIAVSVVAALMTVLLAWLLTRSIVTPLSRAV
                     QAAETIAGGNLTKTIEVDGKDEPARLLGALSTMQASLRQTIEQIAGSATQLGAAAEELS
                     TVTQDASRGLQQQNNEIEQAATAVNQMTAAVEEVARNAVSTSEASSQSTQAAREGRDRV
                     VETVGAIQTMTHDVHNTSLMIEGLAAQGRDIGKVLDVIRAIAEQTNLLALNAAIEAARA
                     GEAGRGFAVVADEVRALAHRTAQSTQEIEKMVAGIQNGTGEAVASMQQSNQRTQDTLEM
                     ARAAGVALEQITQSIHLINERNLVIASASEEQAQVSREVDRNLVNIRDLATQSAAGANQ
                     TSVATHDLSRLAVDLNGLVARFVI"
     gene            complement(8717..10027)
                     /locus_tag="F8N66_RS17525"
                     /old_locus_tag="PS918_03337"
     CDS             complement(8717..10027)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015094560.1"
                     /locus_tag="F8N66_RS17525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PS918_03337"
                     /product="ATP-binding protein"
                     /protein_id="WP_150771371.1"
                     /transl_table=11
                     /translation="MNVSMRWPRTLASRLSLIFLIGLILAQALSFGAQYYERYESAKNT
                     MLGNLETDVSTSIAILDRLPVDERASWLQQLERRNYRYLLDEGSPGNVMGMDMPDAPIA
                     MASIKDAIGKDYPMTFTDIPGPRKHFQVHLKLSDGSPLTIDVRPSMVPLSPWLPIVLLG
                     QLALMLACTWLAVRIAIRPLSRLAEAVDTLDPNTHPVLLDEKGPTEVAHAARAFNAMQA
                     RIAAYLKERMQLLAAISHDLQTPITRMKLRAEFMDDCLEKDKLWNDLSEMEHLVREGVA
                     YARSVHGATEESRRTDLDSFLDSLVFDYQDVGKQVQLSGKSATVIDTRPHALRRVLVNL
                     TDNALKFAGAAELQVEKKADGSVSVKVMDRGPGIAEAELAQVMEPFYRVENSRNRSTGG
                     TGLGLAIAQQLALAIGGSLTLSNREGGGLCAELKLRG"
     gene            complement(10024..10764)
                     /locus_tag="F8N66_RS17530"
                     /old_locus_tag="PS918_03338"
     CDS             complement(10024..10764)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014718447.1"
                     /locus_tag="F8N66_RS17530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PS918_03338"
                     /product="response regulator"
                     /protein_id="WP_150771372.1"
                     /transl_table=11
                     /translation="MEHVDHILIVDDDREIRELVGNYLKKNGLRTTVVADGRQMRTFLE
                     STPVDLIVMDIMMPGDDGLMLCRELRAGKHKATPILMLTARNDETDRIIGLEMGADDYL
                     VKPFAARELLARINAVLRRTRMLPPNLVVTETSRLLAFGRWRLDTSARHLLDDDGTMVA
                     LSGAEYRLLRVFLDHPQRVLNRDQLLNLTQGRDADLFDRSIDLLVSRLRQRLLDDAREP
                     AYIKTVRSEGYVFSLPVEIMGAPA"
     misc_feature    complement(10793..10808)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.44"
                     /tool="antismash"
ORIGIN
        1 atgaccgtca agcagatccg cgccttcctg gccgttgccc aaagcctgag tttcgccgtg
       61 gcctgcgagc gcctgcacct gtcgcaatca gccctgagcc tgaccatcaa ggcgctggaa
      121 gaaggcctgg gcggacgcct gttcacccgc aacacccgca acgtggcgct gaccgccgag
      181 ggcgagtccc tggtgcccct ggcgcgccgc ctgatcgctg actgggacaa cgccgaggac
      241 gaactgcgcc agcgtttcac cctgcagcgc ggccgcgtga ccctggcggc catgccgtcg
      301 tttgccggta acctgctgcc accgatcctc aagaccttcc gcgcccggta tccgaaagtc
      361 aacgtcaccg ttaacgatgt gatcaacgaa caggtgctgg aaatggttcg cgaccgccag
      421 gtggaactgg gggtggcgtt cgagccgacg cagaattcgt cgctgcaatt caccccgttg
      481 tacatcgacc ggttcgtggc ggtggtgccc catgactcgg cgctggtcga gcgcgatcac
      541 atcgactggc agacgctgct gatggaaccg ttcatcaccc tgcaacgccc atccaccgtg
      601 cgggtgatgc tcgaggagca tttgcaggcc cggggcatga agttgccggt ggagttcgaa
      661 agccatcaac tggcgaccgt ggggcgcatg gtcgccagcg gcttgggcgt cagcgccgta
      721 ccggccttgt gcgccgggca gatgcgcgag ctgggcgcgc actgcatcac cctgagcgac
      781 ccggtggtgg aacgggccat cggcgtgctg accttgcccg ggggagagct gtcggcggcg
      841 gcgcaggcgt tgtttgatgt gctgaaagaa gagaacttcg ggcagcaact gtcttcgcgg
      901 tgatacacaa aaccaaatgt gggagcgggc ttgctcgcga aagcggcgtg ccagtcaata
      961 gggttgtcga ctgacgcacc gctttcgcga gcaagcccgc tcccacaagg aatggttttt
     1021 ttcagagtga taggcgctgt gccaataacg gcaataactg ctcgcacgac ccttcgatct
     1081 tcaaatccag cagctcatcc gcccgggtct tgcccaggtt gattgcgatc agtggcttgc
     1141 cctgatccac caccgaccgg cacaggcgaa acgccgaata cgccatcagc gacgagccga
     1201 ccaccagcag ccccgccgct ttttccaccg tcgccatggc tttggccgcg gtttcctggg
     1261 cgacgttctc gccgaaaaac accacatccg gtttcatccg ctcgcccgtg cagtgggggc
     1321 agtgcgggac ctgaaagcgc gcttcgaagg cgctgtccag cagggtatcg ccgtccgggg
     1381 cctgcacggc gtccacgccc gcaagatagg ggttctgcgt ttccatcact tgctggatcg
     1441 cgtcgcgctc gcagcgctgt ccgcagtcca ggcacaggac ccggtgcagg ctgccgtgga
     1501 gttcgatcac gtcgtggctg ccggcctggt cgtgcagggt gtcgacgttc tgcgtgatca
     1561 ggccgccgat cagccgggtg ctctgcaagt gggccagggt gtcgtgggcc acattcggca
     1621 ttgcgtggcg cacccgtggc cagccgagca tcgcccgggc ccagtagcgc cgccgggatt
     1681 cgggtgccga gagaaactcc tgatacatca tgggctgccg gccacgacgc acaccctgat
     1741 ggtcgcgata gtcgggaatg cccgacggcg tgctgatacc ggcaccggtc agcaccgcga
     1801 acggctcgtc ggccatgagt tgccggaggc ggtcgagctg ttcgtggatc aggctgtcga
     1861 tcatggagag aaccccgcaa tacctgtagg agctgccgca ggctgcgatc ttttgacttt
     1921 gatcttgaaa aagcaagatc aaaagatcgc agcctgcggc agctcctaca caagcggtgt
     1981 ttatttgcgg gcctcaagaa tcaggttgaa cggcgtctcc gtagcccgcc tgaaactcga
     2041 aaaaccggcc tcgctgaaca ctttgcgcaa ccgcgcctcg cccgcctggg cgccaaggcc
     2101 cagtccaacc tcctgagata gcgagttcgg tgtgcagatg aaggtcgagg ctgcgtagaa
     2161 caaccggccg accggggtga tgttgtcgtc gagggaatca ttggcgaagg gttccaccag
     2221 caacaccgtg ccgtccggct tcaacgagtc gtaggcatgt ttggccgcac cctccgggtc
     2281 gcccatgtcg tgcagacagt cgaagtagca gaccaggtcg tagtcgtcgc cggggtaact
     2341 tttggccgtg ccctggaaga accgggcccg cccggacacg ccgccctctt cggcgcgttg
     2401 ggtggcgacg gtgacggagg gcgcgtggta gtcgaagccg acaaaccgcg aatccgggaa
     2461 cgcctgggcc atgatcaccg tcgaggcgcc gtggccgcag ccgatgtccg ccactttggc
     2521 cccggcctcc agtttcgcca ccacgccatc cagcgccggc agccattcgg cgatcaggtg
     2581 cgccttgtag ccgggccgga agaaccgttc ggtgccgctg aacatgcacg gatggtgatc
     2641 gccccagggc agggcgccgt cgccgcgcat ggccttgacc agtttgtcct tgtcatggaa
     2701 aaacgacgcg accaccccga tgcccccggc gatgtagacc ggcgaatctt cgatggccag
     2761 ggccagggct tgttcttccg gcaggcggaa ctggccgcct gagtgttcca tgtagcccga
     2821 ggcggcgtgg gcgctaagcc attcgcgcac cagacgggca ttgcagccgg ttttttcggc
     2881 gagtgcttca gggctgatga gctggctgtc ggccatcgcc cggtacaggc cgagctcctc
     2941 gccgaggatg acattggcga gcatcgccgc gccgcccatg tcattcacca gtttgcccat
     3001 gaaatcattg agtctggcct cgtccatcac gtgtgctcct tcaggaggat cacggtccag
     3061 aggcagggtt tgcctgggtt ttcgccgctg ggcggtggtc gtgggaatgg gcagggcgaa
     3121 aggcacgtcc tgcgtgcatt aagtttagtc cgcatggggt gcactgttac cccagtcgac
     3181 gagagtcctc tgtgggagcg ggcttgctcg cgaaggcgca gtgtcagtcg acatcttctg
     3241 tgactgaccc accgctttcg cgagcaagcc cgctcccaca gggggatagt gttcagcagg
     3301 cctttgtatg tatctcactg tatccagccg gcttcccgat acagttcccc tcaattcacc
     3361 gccactgccg aacacagacc agatacaaac ctgcgatgaa ctgttcaggc tgttttggcg
     3421 ccgttcaacc gtgacggcca agactttttc cctggccgcc gccaccggcg accgttcgct
     3481 cctgactctg tgccgcgcct gatgcggtca aggggaccac aatgacaacg cttgttcctg
     3541 aatccacgct cgacaccacg ccggtcgatc gcctgcgggt cgatcactac accaatggca
     3601 tcatcggccc gagccagccg atgctgggcc cgctggcgga cggcggcacc ctgatcaccg
     3661 ggacgccgcc gggctgctgg ggaccaatga tcacgccggc ctttgaaggc ggtcacgagg
     3721 tgacgcaacc ggtgtacgtc gccggcgcag agatcggcga tgcggtggcg atcaagatcc
     3781 agagcatgcg cgtgacgtcg ctggccactt cgtccggggt catgtccttc gtcgaggggc
     3841 gctacaacgg cgacccgttc gtcgccaagt tctgttccaa gtgcggcacc gagcatccgg
     3901 ccagccacgt cgaaggcatt ggcgaggacg cgatccgctg caaccactgt ggcgccgagg
     3961 tcagcgcgtt ccgcttcagc cacggctatg tgatcgtgtt cgacgcacag aaccaggtca
     4021 gcctgacggt caaccaggac atcgccaatc aactggccgg caaggcctcc gaaatgtcgg
     4081 cgctgccgga attcgccgcc cagcattcga tcctgtccct ggcacgcgcc gatatcccgg
     4141 gtgttgccgc gcacatgcgg ccgtttctcg gcaacatcgg caccatgccc tcgcgcgact
     4201 tgcccgactc gcacaactgc gccgacttcg gccagtacct gatcaacgcc ccgcaccgtt
     4261 tcggcatgac ccgcgaagag ctgcacgcag ccaagaccga cggccacatg gacaccaact
     4321 cgatccgcga aggctgcgtg ttgatctgtc cggtgaaagt gccgggcgcc ggggtgtaca
     4381 tgggcgacat gcacgcccag cagggcaacg gcgaaatcgc cgggcacgcc accgattgct
     4441 ccggggaaac cgaggtcgtg gtggaagtgg tgaaaaacct gacgctggaa ggcccgatcc
     4501 tcctgcaaaa cctcgatgac ctgccaccga tggcccggcc aatgaacgcc ggacagcggg
     4561 ccaatgtccg tgcgctgggc gagcgttggg gccagcacga gatcgagcag agcggcccga
     4621 tcactttcct cggcagtggc gaaaacctca acctggcggt agagaacggc ttgcagcgtg
     4681 ccgccaatgc caccggcctg ccgtatgacg aagtgctcaa ccgcgccacc atcaccggtt
     4741 ccatcgacat cagccgcctg ccgggcaccg tgcgcgtgac cttcctgtgc ccgatgccgg
     4801 tgctggaccg catgggcatc ggccatctgg tgcgcgagaa atacgacctg gcgtaatgcc
     4861 tgatccgggg tctgtatcac agtgtgtaca gaccccgcga cgatacacgt cctgccgttt
     4921 tccgtcggcg cgcaacacag agccgataca tcgcttcggt taactgtgag cacgttccga
     4981 caacccctga gatcgacaac atgcagactc ccatcaccta cgccagggcc agcgccgggc
     5041 tcggcttgcg tcgcggttta atgaaggacc tcctggccgc cccggccggc catttcgatt
     5101 tcctggaagt ggcaccggaa aactggatcg gcatcggcgg cgcccacggc gcggcgctac
     5161 ggaccctggc cgagcgctat ccgttgtcct gccacggctt gtcgctgtcg ctgggcgggc
     5221 cgtcgccgct ggatgtcggg tttctgcaag aggtgcgggt gttcctcgat cactacaacg
     5281 tgccgctgta cagcgagcac ctcagttatt gcagcgatga cggtcatctc tacgacctgt
     5341 tgccgttgcc ctttaccgaa gaggcggtgc atcacgtggc cgcgcgcatt cgccaggccc
     5401 aggacattct cggccggcgc ctggcggtgg agaacgtctc ctactacgcc gcgccgcaac
     5461 aggacatgga cgaggtgacc ttcaccaatg ccgtgctgcg cgaagccgat tgcgatctgt
     5521 tgctggacgt caataacgtg tacgtcaact cgatcaacca tggcttcgat ccgcgtacct
     5581 tcctggcggg catcgatgcc aaccgggtag tggcgatgca catcgccggg cacttcgatg
     5641 agtccgatac cttgaagatc gacacccacg gcgcttcggt caaaccggcg gtgtggtcgc
     5701 tgctcgccca ggcctacgcc cgatttggcg cgcaaccgac cttgctggag cgggatttca
     5761 actttccgct gttttccgaa ctggtcgccg agttgcagac catccgccgc ttgcagaccg
     5821 aggaggtgaa ccgtggccaa gcgctcgttg tttgatcagc aaagcagcat gggcctgtac
     5881 ctgcgcgatc ccgagcactg cgcaccgccg ccggaaatgg accccaagcg tgcccgggtc
     5941 tatcgcgacc tggtgttcgc caacctgtcg tcgttgatca gcggcacctt cccggtgctg
     6001 gtgcagattc tcggtgacag tcagtggcgg gcgctggtgc ggattttcct gcgtgactac
     6061 cgcgcccaca ccccgaaatt cggtgaaatc gccgaggaat tcgtcgagtt ccttacctct
     6121 gaacccccgg cgctggccga tggcacgtgg ccgccgttca tggtcgagct ggcgcactac
     6181 gaatgggtgg aaatggccct gcaacaatcc gaagccgagc cgttgtcacc cggtgatgcc
     6241 gacctgttgc cggagcgtcc gttgcaggtt tcgccgctgg cctggccgct ggcgtatgcc
     6301 tggccggtgc aatcggtggg gccggattat cagcccgcta cagtgccggc cgaaccaacg
     6361 ctgctgctgg tgcgccgcgc agacgactgg agtgtgaagt tttccgcctt gaccccgttg
     6421 gcctggcgct tgttgcagcg tatcgatgag ttccctgaat tgagtgggcg agcacagttg
     6481 caagcgttgg cggttgaggc agggcagggc ggatcgcagg agttctttga tagcggcctg
     6541 gcgttgttgc ggcaactaca cgaggaggag gtggtgggcg taatcagctg aggtgacgca
     6601 tttcctgtgg gagcgggctt gctcgcgaag gcggactgtc agtcgacatc tatagcgact
     6661 ggcaggacct cttcgcgagc aagcccgctc ccacagtaaa gctggggtga ggcaagaaat
     6721 aatgcacgcc cgtaccatgt gtttcactcg ggaaacactc gtaacccgtt gaaatttatt
     6781 tgctcgatcc ccgcaaaaaa cctcaagccc ggccgataca actctcaggc gcgcacacac
     6841 cggctacagc agtggcgcca ggctgaaagg gggcatcaat acccgccgtt cagtgatcac
     6901 ggcaaggatg ctcgtcgccc tttcacccga gaatcctcct atgtccctgc gtaacctgaa
     6961 tatcgcgccc cgtgcctttc tggggtttgc cttcattgcc ttgctggtca tcgtgctggg
     7021 tgtgtttgcg gtcaaccgca tgtcgatcat ccgccagtcg tcgatcgaca tgggcagcac
     7081 ccaactgccc agcgtgggtt acctgggcaa tatcaccgaa aacattttgc gtatgcgcat
     7141 tctgtcgttc cgcatcctgg tcaaccgcga gccgggcagt ttgcaggaag cccagacccg
     7201 tatcggcgtg ctgaccgaca atgcgcgcaa agcccaggcc agctacgccg agttgccggc
     7261 gggcccggat gaagcggcgc tgtacaaggc gttcagcgcg accctggaca actacatgca
     7321 ggcccaacgc gaaatgttgg acttgtcgcg ccagaacaaa gtggacgaga tgcgcaccct
     7381 gatcaacacc cggatcaagg acggcaccga ccagatgggc gagcagctga gccgtctggt
     7441 gaagtacaac accgacggcg ccaaggccgc cggggtgatc gccgaaaaca attacaacgc
     7501 cgccgtgaac ggaatcattg cggtgtccgt ggtggcagcc ttgatgactg tgctgttggc
     7561 ctggctgctg acgcgcagca tcgtcacgcc gttgagccgt gcggtgcagg ccgccgaaac
     7621 catcgccggc ggtaacctga ctaaaaccat cgaggtcgac ggcaaggacg aaccggcacg
     7681 cttgctcggc gccttgtcca ccatgcaggc cagcctgcgg caaaccatcg aacagatcgc
     7741 cggctccgcc acgcaactgg gcgccgctgc cgaagaactc agcaccgtga cccaggacgc
     7801 gtcccgcggc ctgcaacagc agaacaatga aatcgaacag gcggccaccg ccgtcaacca
     7861 aatgaccgcc gccgtggaag aagtggcgcg caacgcggtg tcgacctccg aagcctccag
     7921 ccagtcgaca caggccgccc gtgagggacg cgaccgcgtg gtggaaaccg tcggcgcgat
     7981 ccagaccatg acccacgatg tgcacaacac ctcgttgatg atcgaaggcc tggcggccca
     8041 gggccgcgac atcggcaagg tgctggacgt gatccgcgcc atcgccgagc agaccaacct
     8101 gctggcgctg aacgccgcca tcgaagcggc ccgtgccggt gaagccggac ggggtttcgc
     8161 ggtggtggcg gacgaggtgc gggcgctggc ccatcgcacg gcgcaatcga cccaggaaat
     8221 cgagaagatg gtcgccggca ttcagaacgg taccggtgaa gcggtcgcgt cgatgcagca
     8281 aagcaaccag cgcacccagg acaccttgga gatggcccgg gccgccggtg tggcgctgga
     8341 gcagatcacc cagtcgatcc acctgatcaa cgaacgcaac ctggtgatcg ccagtgcctc
     8401 ggaagagcag gcccaggtgt cccgtgaagt cgaccgcaac ctggtgaaca ttcgcgatct
     8461 cgccacccag tccgccgccg gtgccaacca gaccagcgtg gccacccatg atctgtcgcg
     8521 cctggcggtg gacttgaacg ggttggtggc gcggttcgtt atctgacggt gaagggttgg
     8581 cccaaacacc acagcccctt gtgggagcgg gcttgctcgc gaaagcggtg tgccagtcac
     8641 tgtttgtatc gactgatact ccgttttcgc gagcaagccc gctcccacag gttgcgtcag
     8701 cggcgatgaa gatgtgttaa ccccgcagct tgagctctgc gcacaacccg ccaccctcac
     8761 ggttactcaa cgtcaacgat cccccgatcg ccaacgccag ctgctgcgca atcgccaggc
     8821 ccaggccggt gccgccggtg ctgcggttgc gcgagttttc cacgcggtag aacggctcca
     8881 tgacctgcgc cagctcggct tcggcgatgc ccgggcctcg gtccatgact ttcaccgaga
     8941 cgctgccgtc agcctttttc tctacctgca attcggcggc cccggcgaac ttcagggcgt
     9001 tgtccgtcag gttgaccagc acccgccgca aggcgtgggg gcgggtgtcg ataacggtgg
     9061 cgcttttgcc gctcagctgc acttgcttgc ccacgtcctg atagtcgaac accaggctgt
     9121 cgaggaacga atccaggtcg gtgcggcgac tttcttcggt agcgccatgc acgctgcggg
     9181 cataggccac gccttcgcgc accaggtgtt ccatctcgct caggtcgttc cagagcttgt
     9241 ccttctccag gcagtcgtcc atgaattcgg cgcgcagttt catccgggtg atgggcgttt
     9301 gcaggtcgtg ggaaatcgcc gccagcaatt gcatgcgctc cttgaggtag gccgcgatgc
     9361 gcgcctgcat ggcgttgaag gcccgggccg cgtgggccac ttcggtgggg cctttttcgt
     9421 ccagcagcac cgggtgggtg ttggggtcga gggtgtccac ggcctcggcg agacggctga
     9481 gagggcggat ggcgatccgc accgccagcc aggtgcaggc cagcatcagg gccagttgcc
     9541 cgagcaggac gatgggcagc cagggcgaca gcggcaccat ggacgggcgc acgtcgatgg
     9601 tcagcgggct gccatccgac agcttcaggt gcacctggaa gtgtttcctc gggcccggaa
     9661 tatcggtgaa ggtcatcgga taatccttgc cgatggcgtc cttgatcgag gccatcgcga
     9721 tcggcgcatc gggcatgtcc atgcccatga cgttgcctgg cgagccctcg tcgagcaagt
     9781 agcgataatt gcgccgttcc agttgttgca gccagctggc ccgctcgtcg accggcaggc
     9841 ggtcaaggat ggcgatggag gtcgagacgt cggtttccag gttgcccagc atggtgtttt
     9901 tcgcgctttc gtagcgctcg tagtactgcg cgccgaaaga cagcgcctgg gcgaggatca
     9961 ggccgatcag gaaaatcagc gacaaccgcg aagccagggt gcggggccat cgcatcgaga
    10021 cgttcatgct ggcgccccca tgatttccac cggcagggaa aacacatagc cctcgctgcg
    10081 cacggtcttg atgtaggccg gttcgcgggc atcgtccagc aggcgctggc gcaggcggct
    10141 caccagcagg tcgatggaac ggtcgaacag gtcggcgtcg cggccctggg tcaggttgag
    10201 cagctggtcg cgattgagca cccgctgcgg atggtcgagg aacacccgca gcaagcggta
    10261 ttcggcgcca ctgagggcga ccatggtgcc gtcgtcgtcg agcaggtgcc gggccgaggt
    10321 gtccaggcgc cagcgcccga aagccagcag gcgactggtt tcggtcacca ccaggttcgg
    10381 tggcagcatc cgcgtgcggc gcagcacggc attgatccgg gccagcagtt cccgggcggc
    10441 gaacggcttg accaggtagt cgtcggcgcc catttccagg ccgatgatgc ggtcggtttc
    10501 atcgttgcgg gcggtgagca tcaggatcgg cgtggccttg tgtttgccgg cgcgcagttc
    10561 gcggcagagc atcaggccgt cgtcgcccgg catcatgatg tccatcacga tcaggtccac
    10621 cggggtggat tcgaggaagg tacgcatctg ccggccatcg gccacgaccg tggtgcgcaa
    10681 gccgttcttc ttcagatagt tgccgaccag ttcccggatc tcgcggtcat cgtcaacgat
    10741 gagaatgtga tcgacgtgtt ccatggggac ttgcctctat cagtggggga tgtcgcacag
    10801 tctatcgagc cttggctgac tcgcccgcag gcgtttgtat tgcagtgtat ctggc
//
