LOCUS       NZ_CABIWO010000014     27689 bp    DNA     linear   CON 29-FEB-2024
DEFINITION  Paraclostridium bifermentans isolate MGYG-HGUT-00024, whole genome
            shotgun sequence.
ACCESSION   NZ_CABIWO010000014
VERSION     NZ_CABIWO010000014.1
KEYWORDS    WGS; RefSeq.
SOURCE      Paraclostridium bifermentans
  ORGANISM  Paraclostridium bifermentans
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Paraclostridium.
REFERENCE   1
  CONSRTM   EMBL-EBI Metagenomics Team
  TITLE     Direct Submission
  JOURNAL   Submitted (06-AUG-2019) EMG, The European Bioinformatics Institute
            (EMBL-EBI), Wellcome Genome Campus, CB10 1SD, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/29/2024 00:21:00
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,602
            CDSs (total)                      :: 3,499
            Genes (coding)                    :: 3,477
            CDSs (with protein)               :: 3,477
            Genes (RNA)                       :: 103
            rRNAs                             :: 11, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 5, 2 (5S, 23S)
            tRNAs                             :: 84
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 22
            CDSs (without protein)            :: 22
            Pseudo Genes (ambiguous residues) :: 0 of 22
            Pseudo Genes (frameshifted)       :: 2 of 22
            Pseudo Genes (incomplete)         :: 13 of 22
            Pseudo Genes (internal stop)      :: 7 of 22
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 02:03:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 879
            Orig. end                         :: 28568
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CABIWO010000014.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..27689
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="True"
                     /product="cyclic-lactone-autoinducer"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..27689
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="neighbouring"
                     /product="cyclic-lactone-autoinducer"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..20730
                     /candidate_cluster_number="2"
                     /contig_edge="True"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20730
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10730](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10730
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     gene            1007..1561
                     /locus_tag="FY209_RS17100"
     CDS             1007..1561
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FY209_RS17100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_148552163.1"
                     /transl_table=11
                     /translation="MNKEQFNNLDFMEKIEYLNNKLREGQTVIRIREDIGIGEKALQRE
                     VKANGYRYNSKIKQYTPTTETTIEILPTIVADKTTIVGNENTFVVPKQQKQILGYLENN
                     FEVLQEFLEKYKSTTRATTETTTNHIVINLVDDKHLNPKPKSIRINEFVYQDWQQFCET
                     KHYSKQDLISMALKEYMDKYK"
     cand_cluster    1544..27689
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1544..27689
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[11543:17689](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      11544..17689
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="2"
     gene            1744..2061
                     /locus_tag="FY209_RS17105"
     CDS             1744..2061
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FY209_RS17105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_148552164.1"
                     /transl_table=11
                     /translation="MVVKNIRMDLMYKNINNVVMVNDSLVNVLNIDNRLVYALISNFEC
                     GIDIKYIHELMESKGWTREDLNNNINLLLDFKFIEDAGDNVDLEKMKREFESFKNAISL
                     Y"
     misc_feature    2372..2387
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 15.69"
                     /tool="antismash"
     gene            2470..3618
                     /locus_tag="FY209_RS17110"
     CDS             2470..3618
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013235.4"
                     /locus_tag="FY209_RS17110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="replication initiation protein"
                     /protein_id="WP_148552165.1"
                     /transl_table=11
                     /translation="MNDYRDIQNPKILMKNNLLIQAKYSLTLVENRIFLLMMYKLQKES
                     NGVLSCEISHDEFKQIIKHAKDKTIKNISKSLSSLRKKSIFFMEEKANKKGIIWGEYGF
                     LNGFTYDDERKIFKIEASEKIYDLLNNYLQTGYTPANLAALFSMKNYYSQRLYDLLRLW
                     SGTKSVINYSLEDLKMYLQLDESYPEYGNFKRRVILPAIKELNETGYFEIDFKENKIGR
                     KVDSIDFYVKDLDKRKYFTNEDVIADIPSLVVKEVEVTNDNAIFDNKEERTFKSNYVIS
                     SDNGDKHKISEFEFLVPDEDIFTKGTLRSFKKDFRNIDFKNEYMEKAFDDAVSITLERD
                     DVEIIKVSSYKFFKGCLDNKIVEYKLEEKEDVAHKKEMDVFW"
     gene            3666..4478
                     /locus_tag="FY209_RS17115"
     CDS             3666..4478
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FY209_RS17115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_148552166.1"
                     /transl_table=11
                     /translation="MKKPNYEDFIMKRAMDIFAEEGLKFFGIDKKVKDIGPTELVVLDS
                     KNMYMDYTFLMEDDSYIHFEFQTTNKGVDDLMRFRTYEALLNHQTKKHVTTYVVYSGDI
                     KNPVSEYNCGMNTYKVNAISMINEDGDKVFDEIIDKLSCGNNIDKQDIIKLTFTPVMGG
                     KMDKGEKILKAIKLSKEITSPFKRDMESILYAFANKFLSGKDLEKVKEELRVTELGKSL
                     IEEGKEAGEKKKAIEIAKKAILKGMDNETIRDLTDLTIEEIETIRNIM"
     gene            4763..5368
                     /locus_tag="FY209_RS17120"
     CDS             4763..5368
                     /GO_function="GO:0000150 - DNA strand exchange activity
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012464.4"
                     /locus_tag="FY209_RS17120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="recombinase family protein"
                     /protein_id="WP_148552167.1"
                     /transl_table=11
                     /translation="MRKFFYARISTKDQTLERQIVEAKKLGIEEEYIFLEVASGKDFKR
                     PEYQLLKRMLREGDVLYIKSLDRLGRNKQMILDEWNELVKVKKVDIVILDMPLLDTTKY
                     KDMNGLENLISDIILQLLSYMAEDERLRTKERQREGIKIAREKGIKFGRRKIDPGEKFE
                     EVYKEWKSGQITAVKAMEILELKSNTFYRRVKEYELKK"
     gene            complement(5676..6221)
                     /locus_tag="FY209_RS17125"
     CDS             complement(5676..6221)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF022240.4"
                     /locus_tag="FY209_RS17125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF2599 domain-containing protein"
                     /protein_id="WP_148552168.1"
                     /transl_table=11
                     /translation="MRISNKIKSLLALTLCIISFNGVAYANEEEKTIDKMTYKEKIDLL
                     NSYSLDFIENNKEEVDLLANSIEKDEAKIPNLRAVQNSYNMNDYFDYYGKITRDGMLSF
                     SLDPKNTVRILKSNASNAYSAFYDKYQDDDDFKKGPQSTENQYWCHFNYAKIKDRWNLE
                     PVRPVVSGSQMVVKLCNP"
     gene            complement(6208..6882)
                     /locus_tag="FY209_RS17130"
     CDS             complement(6208..6882)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025105.4"
                     /locus_tag="FY209_RS17130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thioredoxin family protein"
                     /protein_id="WP_148552169.1"
                     /transl_table=11
                     /translation="MVNINSNTKVKVDSFKEFNNIKNGYIYFGREDCPACNIFDPVLNS
                     VAKSNLLKINYVDTNLFRDSNLDEFLKKFNVTQVPTLIEVHNGKMIGSFEGEAYNEFGK
                     DSLEKDLKLFVSQSPIQLKVPVHIIITLILNIFIMVLIPITIFSKMNRFKLSKLSIFAL
                     IVNIINLYSHGLFRDKNWISYEYFSYIEYFDKLCWANLIILSIACLVYLLKKRRGIKYE
                     NI"
     misc_feature    complement(7530..7545)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.13"
                     /tool="antismash"
     gene            7892..8608
                     /locus_tag="FY209_RS17135"
     CDS             7892..8608
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018590547.1"
                     /locus_tag="FY209_RS17135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_148552170.1"
                     /transl_table=11
                     /translation="MIRVVICEDNVIFREFLKKSLYNVFLEITNKFEIIEYSCGEDLLN
                     DYPKNIDIYFLDIEMKNINGMELARKIREENCSSEIIFTTALSDYIQDGYEVRAYRYLI
                     KPIEFDELKKHVCSCIKDIYKRNENNLIIHNKGTIYKIQVDSIAYIEVMDKDVTIYTTD
                     NCYEVKTSLSKLEKDLNKYNCKFYRCHKSYLVNMKHIQYIKKNTVFVKNTEIPVSRHKI
                     KDFKLNLADVLGDVIC"
     gene            8602..9903
                     /locus_tag="FY209_RS17140"
     CDS             8602..9903
                     /EC_number="2.7.13.3"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025854.4"
                     /locus_tag="FY209_RS17140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sensor histidine kinase"
                     /protein_id="WP_148552171.1"
                     /transl_table=11
                     /translation="MLEKIFLGNIVTVISAIIEWVVYKYILDEFSNRRKSNLCTNICII
                     LLVLITTILTFKGIKPNTKLLIGMILGYLFYLYNYEYSLKKGLMISLVYWMLLIGIDAI
                     GSSTILMINSINRISFLLYDNMFRLELNILSKILLISFIPFIKTLRIQVDFKRKDFICV
                     IIPIIANILSIVIIFGLLMETNSKRLVIIIASGIMFLANISLIHLIGNMIKSNNIFMEN
                     KLIKEKVNLQYQNYINLQEAQSKVRKLYHDMKNHITCIQGIYGHNELAEKYIENLKNEL
                     NDWKSIFMTGNMILDIILNDKKKICDKNNIDFSVDINFSSCEFIDMLDVCSIFSNMIDN
                     AIEACIKINDKDRNRFIIIKGTIVNGFFVIKCENSKVNEVKFKDKNIKTDKKDSNLHGI
                     GIKSIKTSVQKYDGELFIDYQDYIFTVKIYIPII"
     gene            10001..10606
                     /locus_tag="FY209_RS17145"
     CDS             10001..10606
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016526.4"
                     /locus_tag="FY209_RS17145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="accessory gene regulator B family protein"
                     /protein_id="WP_148552172.1"
                     /sec_met_domain="AgrB (E-value: 7.2e-37, bitscore: 117.7,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKLCANKITSFLIYNESINSDEYELYKYGFETLIAFVINISIIL
                     IISCIVGKFKYTLLFLCCYCPIRQYTGGYHAENYKKCLGVFIMIYLINIIMLECIKVLK
                     LNDIVLLMEFISFIGIWILAPIEHRDKPLTYKEILHYKNVSRILTGIILIVTFIGMNFK
                     LTYEFSMYASSSVIWTFIMLNLAIIKDKGGYKYEEISK"
     gene            10587..10730
                     /locus_tag="FY209_RS17150"
     CDS             10587..10730
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR04223.1"
                     /locus_tag="FY209_RS17150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cyclic lactone autoinducer peptide"
                     /protein_id="WP_148552173.1"
                     /sec_met_domain="TIGR04223 (E-value: 6.2e-11, bitscore:
                     33.5, seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRKFPSKILEYIGKLSICTLKVSANTTCNWMSHQPKIPDGFNKFK
                     NR"
     gene            11177..11350
                     /locus_tag="FY209_RS17155"
     CDS             11177..11350
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03731.1"
                     /locus_tag="FY209_RS17155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_148552174.1"
                     /sec_met_domain="TIGR03731 (E-value: 1.3e-13, bitscore:
                     42.0, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKDFDLNLKMDKAPSNDGKQGITSVAYCTPGCVTGQLCGSSECG
                     LTRNCTGSIACA"
     CDS_motif       11177..11245
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MNKDFDLNLKMDKAPSNDGKQGI"
                     /locus_tag="FY209_RS17155_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       11246..11350
                     /prepeptide="core"
                     /locus_tag="FY209_RS17155_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="1.20"
                     /molecular_weight="3152.6"
                     /monoisotopic_mass="3150.4"
                     /core_sequence="TSVAYCTPGCVTGQLCGSSECGLTRNCTGSIACA"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNKDFDLNLKMDKAPSNDGKQGI"
                     /leader_location="[11176:11245](+)"
                     /alternative_weights="3170.6"
                     /alternative_weights="3188.6"
                     /alternative_weights="3206.6"
     gene            11544..14624
                     /locus_tag="FY209_RS17160"
     CDS             11544..14624
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="FY209_RS17160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_148552175.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 7.1e-117,
                     bitscore: 382.2, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 8.1e-13,
                     bitscore: 40.2, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4e-32, bitscore:
                     103.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQSFKDVGSFMIRTPSLPIDLLVDNIENSNSIDSTMLLSDSSCY
                     KNQFNEAILVASPNLYESMQRYINGDKVRNTDYLLNSVYKYFSRSCSRCTPFGLFSTVA
                     FGDITSEKTSFELSETKLKRKPQVDSNWLFEVVYMYESRYLKSLKYKINESVAVYRNKA
                     NLFNCTQNKNSEKINKKSVNYSKAFEIVLETSNDYVSYSEIIENLKKSYPNVDEGTFHT
                     YVQSLIKEGYLISDLRPPLTITSQLEYFICKLVEYDISSDIFDDIKKQIEIYSAEGKDE
                     KINCLMNIFNNMEAIYNSKNYLAIDSSFDYKECNLNVNEIKNINKLINLFIQFNVNEPF
                     DRLREYKENFLGRYGSSRCVPLIELIDNDFGLGFPSYYDGKSNANNFGEYINPWVRFFE
                     RKYIDSIRLNTEIEITDTDMRMLLFENFETDRLPKTMEIYFNYTKENGKDVFQLSNIFG
                     STHAGKSFGRFSHFMDNPKFFYEKINTAYGNDDESQFCEFVFLPDSLYTANVIRNTHGS
                     TYEMSFGTSNSKDNTSKLKLSDILVGFENNKLYLKSAINNKRIVPTSTNMFNPQLKPKI
                     LRLIDEISSDSIKLYNKPWQNLIEKFAYIPTIRYKNFILEQEKWTLKIDDLGLAKRYNF
                     NEFKKGFSEYIKSRNIPNWVYIVDADKKLLLNLKEDRCLEVLQKSLEKSDLVLERYNAD
                     AEHPVKYNGASYCCELVIPLMLDEEVHSSKTNDAEIDQICSDDRIKEPFDEWLYFKIYG
                     IEENVDYLLGEALLIPLQELLKTGEIDSYFFIQYKDPDRHLRLRLKADKDKLLAVQLKM
                     FDIFSQLMKNSIILKYSIDCYELELERYGGYDLMDYAHEVFHKDSMVVQSIIREKNNHN
                     TEISDELLALVIIFFHMTKFNLSLEDMYIFLNCEHHTKDNQEEFKKNRDTYVEFVINYL
                     SGENVTGEEEFILNILSAKNESMEIYSNKIKEFYPDDKTVKLSILDSLLHMNMNRLFGP
                     YPDLERKMRNLARHTYYSVYNRNKKTGILDGKKNAKI"
     aSDomain        12018..12263
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_FY209_RS17160_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="6.50E-13"
                     /identifier="RREFam001.1"
                     /label="FY209_RS17160"
                     /locus_tag="FY209_RS17160"
                     /protein_end="240"
                     /protein_start="158"
                     /score="40.2"
                     /tool="antismash"
                     /translation="YRNKANLFNCTQNKNSEKINKKSVNYSKAFEIVLETSNDYVSYSE
                     IIENLKKSYPNVDEGTFHTYVQSLIKEGYLISDLRPP"
     misc_feature    complement(14665..14679)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 18.24"
                     /tool="antismash"
     gene            14665..16446
                     /locus_tag="FY209_RS17165"
     CDS             14665..16446
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="FY209_RS17165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_226888304.1"
                     /transl_table=11
                     /translation="MEVIPKSIKIFFQVNKPIFIFTIIINIIAGIVPVISVNILGALID
                     AMSTTNLDMSLKILVIYIGISFLSNIILSTKTFLTTKFQYLLDYELINKLMNKCGNMSL
                     EEFENSDVQDQIQHIQSQIGFRPYSIFTSILILITSITTILSSIFSIIIWQPSAILLII
                     APALAFSIFYLSINKREFQTEESNAKKSRGIWYYEFLLTKDQSFKEVKILNLAKHLIKR
                     HNDLKKNIIKENLYNAKVRLIISMVFDFVDQICMAVLMILIILSVNAGTILIGGAVALL
                     RIINMVFDSFNSIMNIIYSINQNSLYMFKLINFLNDPKTKDDDKKTYSLEDINDIELNN
                     LSFYYPKTDKMVLQNINFKFNKGETIALFGRNGSGKSTLIKLLMGYYLVDDSMIKINGV
                     PLNEINTDSLHKLTGILFQDYCKYELTLKDNVGFGNIDEIDNEHQILESLKKAGVDFLP
                     PNLEQQLGKWFSDGTQLSGGQWQRVALARCFFKKAQLYILDEPNAALDKMGERKIMNTF
                     FELTKNNIGIFVSHKIAHVMLADKIIYLDEGRIVAEGTHEQLLKTCPSYKEIYDLEFNI
                     PINSGEDNDEFIKQQNA"
     gene            16403..17689
                     /locus_tag="FY209_RS17170"
     CDS             16403..17689
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="FY209_RS17170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_148552177.1"
                     /sec_met_domain="LANC_like (E-value: 1.8e-66, bitscore:
                     215.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGRIMMNLSNNKTLELDNLVINLAKKLSNIEYVEDVFALNATDYK
                     HSSVAVSYPALCMLFSELQHTFPQYNFDECAHRYLEKVNNSLGQNNMYDISLFDGLCGV
                     GFAANCMSDNGKQYQSFIRNLNEHILDIADRNILQYRKLPLNELIYDTMYGLTGTANYL
                     LNFKSESRVKNTLLNILQYLVDICTTSIDGIPKFAIRADQSQLFSASNDSRIRYVNLGV
                     SHGIPGMLLILCKSYESGIYVKNQLEAIKYLSEYISNNCVKNSNMIFWEAQKIIGIDND
                     EAMPSRDAWCYGTPGVSYSLLVASKLLNDNEMHNLAIDSMKLSLKSLREVISPTFCHGL
                     SGLCCLSRKFYEYTNDNYFYEMYMKLFEHILDLYSDQHPFGFIDKEIEKGQITNKHEIG
                     LLTGTTGVLLTILSCYKPIKTQWESIFLL"
     gene            18067..18774
                     /locus_tag="FY209_RS17175"
     CDS             18067..18774
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004835594.1"
                     /locus_tag="FY209_RS17175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_148552178.1"
                     /transl_table=11
                     /translation="MDSVLIIDDDKELCTLMKKCVEKENLSAIIAHGGMEGIRLIDENK
                     SSESLSLVILDVMMPDINGFQVLKIIRETSNIPVLMLTAKSDEDDKVSGLRLGADDYLT
                     KPFSISELMARVNSLIRRYTTLNPTFATETDYLALQGMVIDKANRIVYINDIPVELTGK
                     EFDLLSFLASNKGRVYTKKQIYTQVWKDEYAFDDSNIMSFISKLRKKIEPNPDNAFYIQ
                     TVRGVGYRFNREV"
     gene            18777..19700
                     /locus_tag="FY209_RS17180"
     CDS             18777..19700
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005933807.1"
                     /locus_tag="FY209_RS17180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_148552179.1"
                     /transl_table=11
                     /translation="MGLTGFLIIVSAVLLIVVFYLGSKLYRTKQQISVIQEAVTDIKEG
                     NLNRKILTRENDMTRQICYDLNTITTGMQATLINQRQSEQAYKRLMTSLSHDVKTPLAS
                     LVGYLEAIEKNIVTGKEKEEYIEVAIGKAYSLKDFTERLFEWVKLDAGEQIFHFEVCDV
                     NELSRSIVADWIIIIENNNFDYEIDIPETECFARIDVNSYTRILNNLFQNVISHSKGTK
                     LIFDLYEDEKQVTVKVSDNGIGIQSDELSHIFERMYRGDKSRMTAGAGLGLSITKELVA
                     IHNGTIDVESILKGSTTFTIILPKSL"
     gene            19887..20810
                     /locus_tag="FY209_RS17185"
     CDS             19887..20810
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019639192.1"
                     /locus_tag="FY209_RS17185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_148552180.1"
                     /transl_table=11
                     /translation="MNDFVIETKQLTKNYGDQTAVNAVDLHVKKGRIYGLLGRNGAGKT
                     TIMKMILGLTSITSGEVDVFGQNIKGREKRVYPRIGAIIETPGFYPNLTGTENLEIFAK
                     LRGTVSPNAVENALKVVGLPYKDKKLFGKYSLGMKQRLGIANAIMHDPELLILDEPTNG
                     LDPIGIAEVRDFIKNLSVEHGKTILISSHILSEISLLADDIGVIDHGVLLEESSMEELG
                     KKNRSYIMLQVSDIPKASLILEREFNLKDYSVQDDQTLRLYDTTLDIGKINKALVMQNI
                     TVISSVLCHDTLEDYFKKITGGEGIA"
     gene            20803..21525
                     /locus_tag="FY209_RS17190"
     CDS             20803..21525
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434216.1"
                     /locus_tag="FY209_RS17190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_148552181.1"
                     /transl_table=11
                     /translation="MLNLIQTEFLKLRRNKLIWLMLLAALIMPFFALLYFNYFGNKGVD
                     PIKYYRWSALGFTLIIILPVILGILSTMLMHEENQHDMLKQLWIVPISKMGYFFSKFFV
                     VLVYSICFMLITFVASVMFSVLSGYVVFEWGSVFYLLKKCVVGGFFTAFAMLPILAIAS
                     SKKGYILPVCITLVYVFFAFLIMPVNMYLHPISSMGVIVDIPGIVQAINVPLAFLCICV
                     WDIISVFFANIALKRSEV"
     gene            21529..22263
                     /locus_tag="FY209_RS17195"
     CDS             21529..22263
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434217.1"
                     /locus_tag="FY209_RS17195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_148552182.1"
                     /transl_table=11
                     /translation="MRKLLWAEIQKIRRLNIVWIAVFATVMVAVIVFIQGWVAYNGSRD
                     IDSAGWYMTMAQPLATFFVLPAVISLLGSYMICREEDEDTIKSLLLIPVNETKLIATKM
                     IITFLFSIFIYLLLFAIAFLTEVILHLSDLSVGMVLYFLKIYFLQGVGIFLAISPIIAL
                     VSYMKKGYWIALVLTEMYSFAGLFMSMSNTLKTFYPIAAVFGVSGYTEATAQSRIGSII
                     ILLLCGCLSVFILKGFRYSEKN"
     misc_feature    complement(22840..22854)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 18.24"
                     /tool="antismash"
     misc_feature    22841..22855
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 21.08"
                     /tool="antismash"
     gene            23238..24527
                     /locus_tag="FY209_RS17200"
     CDS             23238..24527
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FY209_RS17200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="response regulator transcription factor"
                     /protein_id="WP_148552183.1"
                     /transl_table=11
                     /translation="MGMKEFCDHLYDDSTDGYIQVLKLNDEKNKSERTIKIYNTRHEGL
                     KDVVEELHEQNDVFVAPNTMYIPKRRVENIRQFRSLFQDIDCENLGFEKAETVYLIWEL
                     YYEGKIPKPTMVTDSGRGVHLYWRIQNAPYGALNTWQELQDYIYYNLKHLGADRQATDS
                     ARVLRLPGTINSKNQVNCEVLYIDDELEYSMYDLREKYLNYRPKSYQLQMEDTKVVENK
                     VISNRFFNSYSLHMQRANDLQTLCRLRKFDMKGYRNMAIHCYAYWKGIYVRDQYELEKE
                     VIELNKAFKEPLKDTEVKAVLRCIPKAIEKFIAYEQGLRSGEKKRVSKGMRDKEGYWYK
                     NTTLIERLGITANEQKHMKTIIGTDEKYERNNERRRAERRNEAGLTKKQQELQDLKIKI
                     MKLKEQGLSNRAIGKQLNISEGKVRTTLKK"
     misc_feature    complement(23257..23268)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     gene            24776..24964
                     /locus_tag="FY209_RS17205"
     CDS             24776..24964
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FY209_RS17205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_148552184.1"
                     /transl_table=11
                     /translation="MKKIKSLFKFEVFESVIEFLKTQNEYKELKGNVQGKNFKLNQCDE
                     FNLDTVDGYIANKYYGV"
     gene            complement(25186..25326)
                     /locus_tag="FY209_RS18385"
     CDS             complement(25186..25326)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024249.4"
                     /locus_tag="FY209_RS18385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YvrJ family protein"
                     /protein_id="WP_148552185.1"
                     /transl_table=11
                     /translation="MTLVSNLGFPAIVTMYLLIRIEGKLENLSTSINSLSSNIYELNNK
                     K"
     gene            complement(25481..25642)
                     /locus_tag="FY209_RS17215"
     CDS             complement(25481..25642)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF022597.4"
                     /locus_tag="FY209_RS17215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF2922 domain-containing protein"
                     /protein_id="WP_148552186.1"
                     /transl_table=11
                     /translation="MRNIETRSLMVFSTYLGRKVSLFVSYSKEDITEAEIKEAMDQIVV
                     KNVFAPRF"
     gene            25911..26717
                     /locus_tag="FY209_RS17220"
     CDS             25911..26717
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1157: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018590489.1"
                     /locus_tag="FY209_RS17220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ParA family protein"
                     /protein_id="WP_148552187.1"
                     /transl_table=11
                     /translation="MKICSFFNVKGGVGKTTLTILTAMKLSKEGKKILLIDADTQANLT
                     QFLYKVVHDDKTLFQMLTENTTAKEVILKSPVEEFKNIDIIPSDISLSVLSEYLSTQMG
                     RERAVWRWFKNNIDDIEKYDYIFVDLSPSYDLIARNFMLISDSIITPIEYQDIASIRGC
                     ELFYQKFKQDLEFLDIKSNTKRAVVINSYTTRKLSTGDLFNSYLDKFENIKTDLLQARI
                     SETTVVRNAILNKMDLEDYCRKIKKAHKVRSDFNEFIEELKAKEVL"
     gene            26718..27083
                     /locus_tag="FY209_RS17225"
     CDS             26718..27083
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FY209_RS17225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_148552188.1"
                     /transl_table=11
                     /translation="MALDIFKEDVSDIKIRKNDYQNKVDSIIEDTLDIDIEGVNLLDMK
                     EEKKAKKIPLTIYLEEEELEILKSVSVLKNTTVQKTIGNLVKSTVNTTKANLPSDFNIH
                     DMVKKYNKENKVKKNKK"
     gene            27309..27563
                     /locus_tag="FY209_RS17230"
     CDS             27309..27563
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020345.4"
                     /locus_tag="FY209_RS17230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Mor transcription activator family protein"
                     /protein_id="WP_148552189.1"
                     /transl_table=11
                     /translation="MDLKMSDLPPQFENIAMEIGIDRVKALFKEFGGTSVYFPTEKMIY
                     KDARDREIIEEFNGFNVKALASKYRMSESYVRAIIRKNK"
ORIGIN
        1 tattttgtat aaggtttgta ttggagccta cagagatgaa aataatgctt taaatcaggc
       61 taaattagct aaagaaaagg gatttaaaga tgcttatatt gtttaaattc aaatatccat
      121 gaaacttttt ttattgtaaa gtgggaaaat tattgattat gctataatga tttagaaaat
      181 gtataattga catttttttg tatttaaaac tagggggagt aaaaatggaa ttgaagctac
      241 ttataggttt atcatggagt aatttaatag tgtctagttt aatagtaatt ttaatttatt
      301 atattgggat aaagtttata aaaaagatat ttatattatt taaatataaa tgagaaacat
      361 ctgttttagt aattactaga ctagatataa tttctgatat agttaagtta taacaattat
      421 aaaattaagg tgattaagta aatatggata tcctttcaaa ttttttacca catacaatag
      481 tcctatgaat ataggtgata ctatttttta ctctacagca tttgatctat ttggattatg
      541 tatgaacata gtagttatat attatataat ctatgtattt aataaactta taaataaaat
      601 agttacaagg taaatattaa tttaagtagg gtaataatat aaaattatta ctctattttt
      661 gtgttgaaaa aacatatatt ttagatatag attactcttt aaaagctagt gttgtactag
      721 cattggatat cagagcaatg attttatcca atgcgtgata tcacgaaggt agtttcatac
      781 cgtaaccaag ctgattttac tgttaatcat tattaaatat atataaatag agtttagaaa
      841 agttgtagtg gatttgtaat aaattgtagt ggttaaatta aagatgtaat ggttttgacc
      901 cgaatgtgta gataaagtca ccaaatgaac ttaaattttg aataaaataa ataaacaact
      961 acagaaaatt acagttgtag tttataataa aaattgaggt gatagtgtga ataaggagca
     1021 atttaataat ctagatttta tggagaagat agagtattta aataataaat taagagaagg
     1081 tcaaactgta ataagaataa gagaagatat aggaatcgga gagaaagcat tacaaagaga
     1141 agtaaaagca aatggatata gatataacag taaaattaag caatatacgc ccactacaga
     1201 aaccactata gagatattgc ctacaattgt agcggataaa actacaattg taggcaacga
     1261 aaatacattt gtagttccaa aacaacagaa acaaatttta ggatatttag aaaataattt
     1321 cgaagtttta caagagtttt tagaaaaata taagtccact acaagagcca ctacagaaac
     1381 cactacaaat catatagtca ttaatttagt agatgataaa cacttaaatc ccaagcctaa
     1441 aagtataaga ataaatgaat ttgtatatca agattggcag caattttgcg agacaaagca
     1501 ttatagtaaa caggatttaa tatctatggc gcttaaggag tatatggata aatataagta
     1561 gaagtattta taaaataatt aatagatgaa ggaaaaaaag aaaaagctat agagatagca
     1621 aagaaggcaa ttttaaaagg aatggataat gaaactatag gagatcttac agatttatct
     1681 attaaggaaa ttgagcttat aagaaaagtt atgaattaaa aatgaatatt aaagggtgat
     1741 tatatggtag ttaaaaatat cagaatggat ttaatgtata aaaacattaa taatgttgtt
     1801 atggtaaatg atagtttagt taatgtatta aatatagata atagacttgt atatgccctt
     1861 atatcgaatt ttgaatgtgg aatagacata aagtatatac atgagcttat ggagtctaag
     1921 gggtggacaa gagaggattt aaacaataat ataaatttac ttctagattt taagtttata
     1981 gaagatgctg gagataatgt agatttagaa aaaatgaaaa gggaatttga aagttttaaa
     2041 aatgcgatat ctttatatta ataataggca cattaaaaat atgtgtcttt tttgttgtac
     2101 atttatagtt ataaataaag tattgtgttt gaaaatagga cagattagaa cagaaaaatt
     2161 acctttacta gtctttactg tatttaaaag aagtatttaa agtatttaaa gtatttagac
     2221 atagcttaaa gctttggaaa tactgagatt taaagcttta aaaatgtcag attggaattt
     2281 taatatgtca ctttggaact taaaaatgtc aagttggaat ttttaatatg tcactttgga
     2341 acttaaaaat gtcagattgg aattttaata tgtcactttg gaattactaa aaatgtcaat
     2401 tgatttaagt tgacattttt aaatcataaa tttatagtta atataaatat tgtataaaga
     2461 ggtattaata tgaatgatta tagagatatt caaaatccta aaatattgat gaaaaacaat
     2521 ttacttattc aagcaaaata tagtttaaca ctagttgaaa atagaatttt tttacttatg
     2581 atgtataaac ttcaaaagga aagtaacgga gttttaagtt gtgagatatc acatgatgaa
     2641 tttaagcaaa taattaaaca tgcaaaagat aagactataa agaatatttc taaatcttta
     2701 agttcattaa gaaagaaaag tatatttttt atggaagaaa aagcaaataa aaaaggaatt
     2761 atttggggag agtatggatt tttaaatggt tttacatatg atgatgagag aaaaattttt
     2821 aaaattgaag catctgaaaa aatttatgat ttattaaata actacttaca aacaggatac
     2881 actccagcta atttagcagc attatttagt atgaaaaatt attattcgca aagattatat
     2941 gatcttctta gactttggag tggaacaaaa tcagtaataa attatagttt agaggattta
     3001 aaaatgtatc ttcaattaga tgaaagttat cctgaatacg gaaattttaa aagaagagtt
     3061 attcttcctg ctataaaaga acttaatgaa acgggatatt ttgagataga ttttaaggaa
     3121 aataaaattg ggagaaaagt tgattctatt gacttttacg ttaaagattt ggacaagaga
     3181 aagtatttta ctaatgaaga tgttatagca gacataccaa gtttagtagt taaagaagtt
     3241 gaagttacta atgataatgc tatttttgat aataaagaag agagaacatt taaatcaaac
     3301 tatgttattt ctagtgacaa tggagataag cataaaatta gtgaatttga gtttttagtt
     3361 ccagatgaag atatatttac taagggtact ttaagaagtt ttaagaagga tttcagaaat
     3421 attgatttta aaaatgaata catggaaaaa gcttttgatg atgcagtatc tataactttg
     3481 gagagagatg atgtagaaat tattaaagtt agttcctata agtttttcaa aggttgtttg
     3541 gataataaaa tcgttgaata taagttagaa gaaaaagaag atgtagctca taagaaagaa
     3601 atggacgtgt tttggtaggt attttaataa ataaggtgat ataattaatt aaaggcggtg
     3661 aactaatgaa aaagccaaat tatgaagatt ttataatgaa aagagcaatg gatatttttg
     3721 cagaagaagg tcttaagttc tttggaatag ataaaaaagt aaaagatatt ggcccaactg
     3781 aattagttgt tttagatagt aagaatatgt atatggatta tactttctta atggaagatg
     3841 atagttacat acattttgag tttcaaacta ctaacaaggg tgtagatgac ttaatgagat
     3901 ttagaactta tgaagcgcta cttaatcatc aaactaaaaa gcatgttact acatatgttg
     3961 tttattcagg ggatatcaaa aaccctgtaa gtgaatataa ttgcggtatg aacacttata
     4021 aggtaaatgc tatatctatg attaacgaag atggagataa agtatttgat gaaataatag
     4081 ataaactatc ttgtgggaat aatatagata aacaagatat tataaagctt acatttacac
     4141 cagttatggg tggaaaaatg gataaaggtg aaaagatttt aaaggctata aagttaagta
     4201 aagaaataac tagtccattt aaaagagata tggaatctat tttatatgct tttgctaata
     4261 aatttttaag tggtaaagat ttagaaaagg taaaggagga acttagagtg actgaattag
     4321 gaaagagtct tattgaagaa ggaaaagaag ctggtgaaaa aaagaaagct atagaaatag
     4381 ccaaaaaagc tatattaaag ggaatggata acgaaactat aagagatctt acagatttaa
     4441 cgatagaaga gattgaaaca ataagaaata ttatgtagtt ataatataat ttaagattaa
     4501 gtaaaaaatg aagagcaaca gttcttcatt tttttattat atatttaaac tgattatttg
     4561 aaagcatacc atttatacct aaaaactacc attcacgcaa aaactataaa aataagaacc
     4621 cctttcaaaa agtctacttt ttgaaagggg ttcttatttt tattttttat aattcaaaat
     4681 ataaacaatt ttctatttga aacatttcaa aaaaatagta tacttattga aagaaaaaat
     4741 gacacttgaa aggataacct gtatgagaaa atttttttat gcaaggataa gcaccaaaga
     4801 tcagacatta gaaagacaaa ttgtagaagc taaaaaatta gggattgaag aagagtatat
     4861 atttctagaa gttgcgagtg gaaaagattt taaaagacct gagtatcaac ttttaaaaag
     4921 gatgcttaga gaaggcgatg tattatacat aaaatcatta gacagacttg gaagaaataa
     4981 acaaatgata ttagatgagt ggaatgaatt agttaaggtt aaaaaagtag atatagtaat
     5041 tttggacatg ccacttttag atactacaaa gtataaagac atgaacggac tagagaattt
     5101 aatatcagat ataatacttc aacttttaag ttatatggct gaggatgaaa gacttagaac
     5161 taaagaaaga caaagagaag gtatcaaaat agcaagagaa aaaggtatta agtttggtag
     5221 acgtaaaata gaccctggag aaaaattcga agaagtttat aaagaatgga aatcaggaca
     5281 aattactgct gttaaagcaa tggaaatctt agagttaaaa agtaatacgt tctatagaag
     5341 agttaaggaa tatgaattaa aaaaataaat acaactccaa ttttatagag aggagaagaa
     5401 atgtaggata tagagaattt taaggattac ctatagtatt gaaccaaata agttagctaa
     5461 atataagtaa tttcaatctg cttaacatgg atataagtat taacaattat aagacaagca
     5521 gaaaattttt ttagagcaat atcaatatat ttactattat aactaatctt tttaagaccc
     5581 cgagttaatg tagaatttat atattgaaat aataaaaaaa agaaaaagaa taatttattt
     5641 ttaataaatt attctttttc ttttttttat tatttttatg gattacataa tttaactacc
     5701 atttgagagc cactaactac tggtctaact ggctcaagat tccatctatc ctttatttta
     5761 gcataattaa aatggcacca atattgattt tctgttgatt gagggccttt tttaaagtca
     5821 tcatcatctt ggtatttatc atagaatgct gaatatgcat tagatgcatt acttttaagt
     5881 attcttactg tattcttagg atcaagacta aaagataaca ttccatctct tgttatcttc
     5941 ccgtaataat caaaataatc attcatatta taagaatttt gtactgctcg taaatttgga
     6001 attttggcct catctttttc tatcgaatta gctaataaat caacttcttc cttgttattt
     6061 tcaataaaat ctaaagagta agaattaagt aggtctattt tctctttata tgtcatttta
     6121 tcaattgttt tttcttcttc atttgcatat gcaactccat tgaaacttat tatgcataga
     6181 gttaatgcta gcaacgattt aattttatta gatattctca tattttatac cccttctctt
     6241 ttttaataaa tataccaaac aagcaattga taaaataatt aggttagccc agcatagttt
     6301 atcaaagtat tctatataag aaaaatactc ataactaatc cagtttttat ctctgaataa
     6361 tccatgagag taaagattaa taatatttac tattaaggca aatatgctta atttacttaa
     6421 tttgaatcta ttcatttttg agaagattgt tattgggatt aacaccatga taaaaatatt
     6481 caatattaaa gttattatga tatgtactgg tacttttaat tgaattggac tttgtgacac
     6541 aaacaattta agatcctttt ctaaagaatc ttttccaaat tcattatacg cttcaccttc
     6601 aaatgaacct atcatttttc cgttgtgcac ttctataaga gttggaactt gtgttacgtt
     6661 gaattttttt aggaactcat ctaaattact atccctaaat aaattcgtgt ctacataatt
     6721 tatttttaac aaattacttt ttgctactga atttaaaact ggatcaaaaa tattacaagc
     6781 aggacaatct tccctaccaa aatatatata tccatttttg atgttattaa attctttaaa
     6841 actatcgact ttgacctttg tattactgtt aatattaacc ataaataaaa atactgatat
     6901 taatattaat gttaatattc ctaaagttat tttaactctg ttcttaataa taccgccccc
     6961 taaatctgac taaaacttct atgatatatc taaaatttag acataaatac taaaaaacct
     7021 cttttttcta ataacgaaaa attcaaatat tgtttataat accttgttta acagttagtc
     7081 aagaagtata cttaaattca atttttatat atttaatatg ggctttctca tatgttcaga
     7141 gtcagagtta aaaatggaaa gaatggtata attttaattt tctttaaatg ttttaatata
     7201 tagttttatg ataaatcttg gattaatagc tcagaaaatt taaaaaacaa actgaattta
     7261 aaaacatgaa aaatatatta atagtatatt gtagagtttc aacaaatgaa taaaatttag
     7321 ataggcagat agaaagttta aagaatatat tttaatagag caatttatat aagattaaag
     7381 gaattataat aaattatata gtatacttaa atgtttttat gattaaagag ctattataaa
     7441 ataaataatt ataactcata aagtatagtt atttagataa attaaattta ggaagattaa
     7501 acatatgatt ggataaaaaa ttaataatag tgactggcaa gtgaacttta aaaaacatat
     7561 acgaatatat ctttttatgt tagaattgaa ttaggcaaaa agccaggaaa atcaagtttg
     7621 cagactaatt cccagctttt taagtaatac tttagacaag taaaatatat tacttataat
     7681 tcatgttatc acaatcgtta atatatatca ataagtatta gaattataaa caatcagaga
     7741 ttatttatat aaattataat ggtgtttatt aataaataat tgaaaacccc ctattgtctt
     7801 tagtattaaa atattaaaga caataggggg ttttcaatta ctaaaaatta aaaatagatg
     7861 ctaaaactgt ataaaagtaa ggggtattaa tatgataagg gttgtaatat gtgaggataa
     7921 tgtgatattt agggaatttt taaaaaaatc tttatataat gtttttttag agattacaaa
     7981 taagtttgaa ataatagagt atagctgtgg ggaagactta cttaatgatt atcctaaaaa
     8041 catagatatt tattttttag atatagaaat gaaaaatata aatggcatgg agttagcaag
     8101 aaaaattaga gaagaaaact gtagttctga aataatattt acaactgcac tttcggacta
     8161 tattcaagat ggatatgagg taagagcgta tagatattta ataaaaccaa ttgagtttga
     8221 tgaactgaaa aagcacgtgt gttcatgtat aaaagatatt tataaaagaa atgaaaataa
     8281 tttaattatt cacaacaaag gcacaatata taaaattcaa gttgatagta tagcgtatat
     8341 tgaggtcatg gataaagatg taactattta tacaacagat aattgttatg aagttaagac
     8401 tagtttatca aaacttgaaa aagatttaaa taaatataat tgtaaatttt atagatgtca
     8461 taaaagttat ttagtcaata tgaaacatat tcaatatata aagaaaaata ctgtctttgt
     8521 taagaataca gagattccag tcagtagaca taaaattaag gatttcaagt taaatttagc
     8581 agatgtatta ggggatgtta tatgttagag aaaatttttt tggggaatat tgttacagtt
     8641 atatctgcga taatagaatg ggtagtttac aaatatatat tagatgaatt tagcaatcgt
     8701 agaaaaagta atttgtgcac aaatatctgc attattttac tagttctcat taccacaata
     8761 ttaactttta aaggtattaa gccaaataca aaacttttaa taggaatgat tttaggatat
     8821 ctattttact tatacaacta tgaatattct ttgaaaaaag gattgatgat tagtttagta
     8881 tattggatgt tactaattgg tatagacgct attggatcaa gtactatact aatgataaac
     8941 tctataaata gaataagctt tttattatat gataatatgt ttagactaga acttaatata
     9001 ttatctaaaa tcttgttaat atcatttatc ccttttataa agacattaag aatacaagta
     9061 gattttaaaa gaaaagattt tatttgtgta attataccaa ttatagccaa catattgagc
     9121 attgttataa tatttgggtt attaatggaa acaaattcaa aaagattagt aataattatt
     9181 gcatcaggaa taatgttttt agcaaatata tcgttgattc atttaattgg gaatatgata
     9241 aagagtaata atatatttat ggaaaacaaa cttataaaag aaaaagtgaa cttgcagtat
     9301 caaaattata ttaatttaca ggaggctcaa tctaaagtta gaaaattata ccatgatatg
     9361 aaaaatcata ttacatgtat acaaggtata tatgggcata atgagttggc agaaaaatat
     9421 atcgaaaatt taaaaaatga acttaatgat tggaaatcta tatttatgac aggaaatatg
     9481 attttagaca taattttaaa tgataaaaaa aagatttgtg ataaaaataa tatagatttt
     9541 tctgtagata taaatttttc gagttgtgaa tttattgata tgttagatgt atgtagtatt
     9601 ttttctaata tgatagataa tgcaattgaa gcatgtatta agataaatga taaagataga
     9661 aataggttta tcattattaa agggactata gttaatggtt tttttgttat caaatgtgaa
     9721 aatagtaaag taaatgaggt taagtttaaa gataaaaata taaaaacaga taaaaaagat
     9781 tctaacttgc atggaatagg aattaagagc ataaaaactt cagtacagaa gtatgatgga
     9841 gagcttttta tagactatca agattatata tttacagtta agatatatat accaattatt
     9901 taaacttata ccagtcacgc tttataatgt accttttacg ccaaatatat tgaaaaaaat
     9961 taaatcaaat ggtattttaa gtgaaaaatg gagaaagaca atgattaaac tatgtgctaa
    10021 taaaataact tcatttctaa tttataatga atcaataaat tcagatgagt atgaacttta
    10081 taaatatgga tttgaaactc taatagcatt tgttataaat atatctatta tacttataat
    10141 aagctgtata gttggaaagt ttaaatatac attattgttt ttatgctgct attgtccaat
    10201 aaggcaatac acagggggat atcatgcaga aaattacaaa aaatgtttag gtgtatttat
    10261 aatgatatac ttaataaata taattatgtt ggagtgtatt aaagtattaa aattaaatga
    10321 tattgtatta ttgatggaat ttattagttt tataggaatt tggattttag cacctataga
    10381 acatagagat aaaccattga cttataagga aattttgcac tataaaaatg tatctaggat
    10441 tttaactgga attatcctta tagttacatt tattggtatg aattttaaat tgacttatga
    10501 gttttcaatg tatgcttcat caagtgtaat atggactttt ataatgttaa atttagcaat
    10561 tataaaagat aaagggggat ataaatatga ggaaatttcc aagtaagata ttggaatata
    10621 taggtaaatt atcaatttgc acattaaagg tatcagcaaa cacaacgtgc aactggatgt
    10681 ctcatcaacc taaaattcca gatggattta ataagtttaa aaatagataa ttaaaaacat
    10741 tacaataaaa gaggtattag aatataaaga tgtattaact tatttatatt ctaatacctc
    10801 ttttatattt aaagatattt atgtttataa attatatgaa ttttataaat acaaataata
    10861 aaaaatgact tttacaccta ttaaaataca ctttacgcaa aaatattgaa aataaaaaaa
    10921 ggttagtgct atattcaaaa catagataag aacttaacaa gcaaaaaact tattggtgat
    10981 tattttaatt aatctattgt gatagttaga ctattacatg tattgaaagt attatatata
    11041 gggttttaaa taacaaaata agatttccta gaatctagta ttttcaataa ttaggcttaa
    11101 tttaataatt aattatgatt ttacggtctt aaaaccttaa aataaaaaat tattaaaaaa
    11161 caagggggaa gaaataatga acaaagattt tgatttaaac ctaaaaatgg ataaagctcc
    11221 atcaaatgac ggtaaacaag gtattacaag tgttgcatat tgcacaccag gttgtgtgac
    11281 aggacaatta tgcggttcaa gtgaatgtgg tttaacaaga aattgcacag gttcaatagc
    11341 gtgcgcgtaa ttaaatactg atgtaaaact taaaagttca tgcatttagg catttgcctg
    11401 aatgcatgac gttttaattt tgtaaaaaaa atattttgaa attatccttg aaattaatgt
    11461 ttaataaaaa caatatattc aatggtttag tatataaaat gtaaagttat gaaagaaaag
    11521 acaagaagga tgtggtaaaa aagatgaaac agtcatttaa agatgtaggt tcttttatga
    11581 taagaactcc aagtctacca attgatttat tggtagataa tattgaaaat tcaaacagta
    11641 tagatagtac tatgctttta tctgattctt cttgttacaa gaatcaattt aatgaagcta
    11701 tacttgtggc aagtcctaat ttatacgaat ctatgcaacg ttatataaat ggagacaagg
    11761 taaggaatac agattatctg ttaaattctg tatataaata ttttagcaga agttgttctc
    11821 gttgtactcc gtttggtttg ttttctactg ttgcttttgg ggatattact tctgaaaaaa
    11881 catcatttga attaagcgaa acaaaattga aacgaaaacc acaggtagat tcaaattggt
    11941 tatttgaagt agtttatatg tacgaatcta gatatttgaa atctcttaaa tataaaataa
    12001 acgaaagtgt tgcagtttat agaaataagg ctaacttatt caattgtaca caaaacaaga
    12061 attcagaaaa aataaataaa aaatctgtaa attattctaa agcatttgaa atagttttag
    12121 aaacatcaaa cgattatgtg agttactctg aaattataga aaatcttaag aaatcatatc
    12181 ctaatgtaga tgaaggaaca ttccatacgt atgttcaatc tctaataaaa gaaggttatt
    12241 tgatatctga tctacgacca ccattgacta taactagtca attagaatat tttatctgta
    12301 aacttgtgga atacgatata agcagtgata tttttgatga tataaaaaaa caaattgaga
    12361 tttattctgc tgagggtaaa gatgaaaaga taaattgtct aatgaatatt tttaataata
    12421 tggaggcaat atataattca aaaaattacc ttgctataga ttcttctttt gattacaaag
    12481 aatgcaattt aaatgtaaat gaaataaaaa acataaataa actgattaat ttgtttatac
    12541 aatttaatgt taatgagcca ttcgatagat taagagaata taaggagaac tttttgggta
    12601 ggtatggttc atctagatgt gttccattaa ttgagctcat cgataatgat tttggattag
    12661 gtttcccttc atattatgat ggaaaatcta atgctaataa ctttggagaa tatattaatc
    12721 catgggtcag attttttgaa cgaaaatata tagattccat aagattaaac actgaaattg
    12781 agatcacaga tacagatatg agaatgcttt tgtttgaaaa ttttgaaaca gacaggttgc
    12841 caaaaactat ggagatttac tttaattata ccaaagaaaa tggtaaagat gtatttcaat
    12901 taagcaatat atttggatcc actcatgctg gaaagtcatt tggtaggttt tctcatttta
    12961 tggataatcc aaaatttttc tatgaaaaaa tcaatacggc atatgggaat gatgatgaat
    13021 ctcagttttg tgaatttgtt tttttaccag atagtttata tactgcaaat gttataagga
    13081 atactcatgg ttccacatat gaaatgagtt ttggaacatc gaattctaaa gataatacaa
    13141 gcaagcttaa attaagcgat attttagtag gatttgaaaa taacaaatta tatttaaagt
    13201 ctgctattaa caataaaaga atagttccta cttcaacaaa catgtttaat ccacagttaa
    13261 agcctaaaat attaaggctt attgatgaaa tttcttctga ttcaattaag ctttataata
    13321 agccatggca aaatttaatt gaaaagtttg cttatattcc aacaatacga tataaaaatt
    13381 ttatattaga gcaagaaaaa tggactttaa aaatagacga tttaggttta gctaaacgct
    13441 ataattttaa cgagtttaaa aaaggattta gcgaatacat taagtcaagg aatataccta
    13501 attgggtata tatcgtggac gcagataaaa aacttttact aaaccttaaa gaagatagat
    13561 gtttagaagt tttacaaaaa tcgcttgaaa aatcagacct tgttcttgaa agatataatg
    13621 cagatgcaga acatcctgtt aagtacaatg gggcgtctta ttgctgcgaa ttggttatac
    13681 ctttaatgtt agatgaagaa gtccattcaa gtaaaactaa tgatgctgaa attgatcaaa
    13741 tctgtagtga tgatagaatt aaggagcctt tcgatgagtg gctatatttt aaaatatatg
    13801 gaattgaaga aaatgtagat tatttattag gagaggcttt gcttatccca ttgcaagaat
    13861 tactaaaaac cggagaaata gatagttatt tctttattca atataaagat ccagataggc
    13921 atttgcgatt gaggttaaaa gcggacaagg ataagttact agcggttcaa cttaaaatgt
    13981 ttgatatttt tagtcaactc atgaaaaatt caattatctt aaaatatagc attgattgtt
    14041 atgagttaga actagaaagg tatggtggat atgatttaat ggactatgca cacgaagtgt
    14101 ttcataaaga tagcatggta gttcaatcaa taattcgtga aaagaataat cacaatacag
    14161 aaatttctga tgaactttta gctttggtaa taatattttt ccatatgact aaatttaact
    14221 taagcttaga agatatgtat atttttctta attgtgagca tcacaccaag gacaatcaag
    14281 aagaattcaa gaaaaataga gatacatatg ttgaatttgt aataaattat ttatctggtg
    14341 aaaatgtgac aggagaagaa gaatttattt taaatatttt atctgcaaaa aatgagtcta
    14401 tggaaatata ttcaaacaaa ataaaagaat tttatcctga tgataaaact gtaaaactaa
    14461 gcatacttga tagtttgtta catatgaata tgaacagatt gtttggacca tatccagatt
    14521 tagagagaaa aatgagaaat ttagctaggc atacatatta tagtgtttac aacagaaaca
    14581 aaaaaacagg aatattggat gggaagaaaa atgcaaaaat ttaaaatatt aagtatttca
    14641 gaaatgaaag aaatgctttc ttctatggaa gtgataccaa aatctatcaa gatatttttt
    14701 caagttaaca agccaatatt tatatttaca ataataataa atattattgc tggtattgtt
    14761 ccagtaattt ccgtgaatat tttaggtgct ttaattgatg caatgtcaac taccaatctt
    14821 gatatgtcgt taaaaatatt agtaatatat attgggatca gttttctatc aaacattatc
    14881 ttaagtacaa aaactttttt gactaccaag tttcaatatt tgttagatta tgaactgatt
    14941 aacaagctaa tgaataagtg tggaaacatg tctttggaag aatttgaaaa ttctgatgta
    15001 caggatcaga tacaacacat tcaatcgcaa ataggtttta gaccgtatag tatttttact
    15061 tcaatattga tattgataac ttcgattact actatacttt catccatatt tagcataata
    15121 atatggcaac cttcagcgat attgcttatt attgctccag cattagcttt ttcaatattc
    15181 tatttatcaa taaacaaaag agagtttcag acagaggaaa gtaatgcaaa aaaatctaga
    15241 ggtatatggt attatgaatt tttgcttact aaagatcaat cattcaaaga agttaaaatt
    15301 ttaaatttgg ctaagcatct cataaagaga cataatgatt taaagaaaaa tattattaaa
    15361 gaaaatctat acaacgccaa ggtacgtctg ataatttcta tggtgtttga ttttgttgat
    15421 caaatatgca tggctgtact tatgatacta ataatattat cagtgaatgc gggtacaatt
    15481 ctaataggtg gagcagttgc gcttcttagg attataaaca tggtatttga tagctttaat
    15541 agtataatga atatcattta tagtataaat caaaatagtc tgtatatgtt taaattgata
    15601 aattttttaa atgatccaaa aacaaaagat gatgataaaa aaacatatag ccttgaagat
    15661 ataaatgata ttgaactaaa taatttgtcc ttttattatc ctaaaacaga taaaatggtt
    15721 cttcaaaata tcaattttaa atttaataaa ggggaaacaa ttgcattgtt tgggagaaac
    15781 ggatcaggta aaagcacatt aataaaattg ctaatgggat actatttagt agatgacagt
    15841 atgattaaga ttaatggggt tccattaaat gaaattaata ctgatagtct gcacaaatta
    15901 acagggatat tgttccaaga ctactgtaag tatgaactta cacttaaaga taatgttggt
    15961 tttggaaata ttgatgaaat tgataatgag catcaaatat tagaatctct aaaaaaagca
    16021 ggtgtagatt tcctaccacc aaatttagaa caacaattag ggaaatggtt ttcagatgga
    16081 actcaactat ccggaggaca gtggcaaagg gttgcactgg ctcgttgttt tttcaagaaa
    16141 gcacaattgt atattttaga tgaacctaat gcagcacttg ataaaatggg tgagaggaag
    16201 attatgaata cattttttga acttacaaaa aacaacatag gtatatttgt ttctcataaa
    16261 attgcgcatg taatgttagc ggataaaata atctatcttg atgaaggtag gatagtggca
    16321 gaaggtacgc atgaacaatt attaaaaaca tgcccttctt acaaagaaat ttatgattta
    16381 gagttcaata tacctataaa tagtggggag gataatgatg aatttatcaa acaacaaaac
    16441 gcttgaatta gataatttag ttataaattt agcaaagaaa ttatcaaaca tagaatatgt
    16501 tgaagatgta ttcgccttaa atgcaacaga ttataaacat tcttcagtgg cagtttcata
    16561 tcctgcttta tgtatgttgt tttcagaact tcaacacact tttccacaat acaattttga
    16621 tgaatgtgcc catagatatt tggagaaagt aaataattcc cttgggcaaa ataatatgta
    16681 tgatatttcc ttatttgatg gattatgtgg agtagggttt gcagcaaatt gtatgtcgga
    16741 taacggtaaa caataccaat cgtttataag aaatttaaat gagcacattt tagatatagc
    16801 agacagaaat attttgcagt atagaaaatt accattaaat gaactgattt atgatactat
    16861 gtatggttta actggtacag ctaattattt gttaaatttc aaatctgaaa gtagagttaa
    16921 aaatacatta ttaaacattt tacaatattt agttgatatt tgtacaacaa gtattgatgg
    16981 gattcctaaa tttgctatta gagcagatca aagtcagctg ttttctgcat cgaatgactc
    17041 taggattcga tatgtaaatt taggtgtgtc tcatggaata cccggaatgc ttttaatatt
    17101 atgtaaatct tatgaatcag gaatatatgt taaaaaccaa cttgaagcaa taaaatattt
    17161 atcagaatac atttccaata attgtgtaaa aaacagcaat atgatttttt gggaagctca
    17221 aaaaatcata ggtatagaca atgatgaagc tatgccatcg agagatgcat ggtgttatgg
    17281 aactccggga gtttcatatt cattattggt tgcttcaaag ctactgaatg ataatgaaat
    17341 gcataatttg gctattgata gtatgaaact atccctaaag agcttgcgtg aagttatatc
    17401 tccaactttt tgtcatggtc tttccggatt gtgttgtttg tctagaaaat tctatgaata
    17461 cactaatgac aactactttt atgaaatgta tatgaaatta tttgaacata tactagattt
    17521 atatagcgat caacatccgt ttggatttat agataaggaa atagaaaaag ggcaaattac
    17581 caataaacat gaaataggat tattaacagg aacgacagga gtgctcttga caattttatc
    17641 ttgctataaa cctattaaaa cacaatggga atcaatattc ttgttataaa aaatgctgat
    17701 agcttgcaaa atactatatt ttgtgaacta tcagcatttc ttttttctta aagggtaagg
    17761 attagtactt aggtggatag tttgtagttg tattttaatt taaaatgtaa tatagaatcg
    17821 aagccgtata ttccgaagaa ttaggggttt tcaacaaatt cacgctttgt tccaaaatgg
    17881 aattcaaaga atttacttca tgtaaatgtc tttggattta ttttgataaa agaatataat
    17941 ataaatatag aatgctgttg gaggaaatag aatggactat atgacaacaa aataaacctc
    18001 taaaatttgg gatatttatc aaagacgcga aaaatcctgt tggcgggcga agaaaggagt
    18061 ttagaaatgg atagtgtttt gattatagat gatgataaag agctttgtac tcttatgaaa
    18121 aaatgtgtag agaaagagaa tttatctgct attattgcac atggtggtat ggaggggatt
    18181 cgtttgattg atgaaaataa aagtagtgaa tctctttcac tcgtaatttt ggatgtaatg
    18241 atgccggata taaatggttt tcaagttctt aaaataatta gagaaacaag caatatccct
    18301 gtgctgatgc ttactgctaa aagcgacgag gacgataaag tttctggatt acggttaggt
    18361 gctgacgatt atctaacaaa gccgttcagt attagcgagc ttatggctcg tgtaaattct
    18421 ctgattcggc gttatactac tttaaaccct acttttgcaa cggaaactga ttacttagca
    18481 ttacaaggta tggtgattga taaagcaaac cgcattgttt atatcaatga tattccagtt
    18541 gaactcacag gcaaagaatt tgatttactt tcatttttgg cttcaaataa aggacgtgtc
    18601 tatacaaaaa agcagattta cacgcaagtg tggaaagatg aatatgcttt tgatgatagc
    18661 aatattatgt cgtttataag caaacttaga aagaaaattg aaccaaaccc cgataatgct
    18721 ttttatattc aaactgttag aggtgtgggg taccgcttta atagggaggt ttagaaatgg
    18781 ggcttactgg atttcttata atcgtatcag ctgtgttact gattgttgtt ttttatctcg
    18841 gttcaaaact atacagaaca aaacagcaaa tcagcgtgat acaagaagcg gtaacggaca
    18901 ttaaagaggg aaatttaaat cgcaaaatac ttacaagaga aaatgatatg acaaggcaga
    18961 tttgctatga tttaaataca attaccacag gtatgcaagc aacgctaata aatcaaaggc
    19021 aatccgaaca ggcatacaaa cgcttgatga caagcctttc tcatgatgtt aaaacaccct
    19081 tggcatctct tgtagggtac ttggaagcga tagaaaaaaa cattgtcacg gggaaagaaa
    19141 aggaggaata tatcgaagtt gcaataggca aagcatacag tctaaaagat tttacagaac
    19201 gactttttga atgggtaaaa cttgatgcag gagaacaaat atttcatttt gaagtatgcg
    19261 atgttaacga actttctcgg agcattgtcg ccgattggat tattattata gaaaataata
    19321 atttcgatta tgaaatagat atccctgaaa cggaatgttt tgctagaatt gatgtaaatt
    19381 cttatactcg aatcttgaat aatctttttc aaaatgttat ttctcatagt aaaggaacaa
    19441 aacttatttt tgatttatat gaagatgaaa aacaagttac agtaaaggtt tcagataacg
    19501 gaataggcat acaatccgat gaactttctc atatatttga aagaatgtat cgaggggata
    19561 aatctcgaat gaccgcggga gcaggacttg gattgtctat tacgaaagaa cttgtagcta
    19621 ttcataatgg tacgattgac gtggagagca ttttaaaagg atctactaca tttaccatta
    19681 ttttgccaaa atctctataa tattaagata tgaaagctct gtcttattca gggctttttt
    19741 tggtaaataa taaaagcaag gaaagaacaa gattacggca aggttatggc aaggtaaatg
    19801 tattacaatt taattatgat tgtttctccc gtaatagggt ttattatatt ggtaaattaa
    19861 atgtattgaa agtgaggaga ttttatatga atgattttgt aattgaaacg aaacaactga
    19921 caaaaaatta tggagatcag acagcagtta atgcagtaga cctccatgta aaaaaaggtc
    19981 gtatttatgg attattaggg cgtaacggag caggaaaaac cactatcatg aaaatgattt
    20041 taggattgac ttcaatcact tccggtgaag tggatgtatt cggacagaat atcaaaggtc
    20101 gagaaaaacg agtatatcca cgtatcggtg ctattatcga aacacccggt ttttatccaa
    20161 atttaacagg aacagaaaac ttagaaattt ttgcgaagct acgtggtaca gtttccccta
    20221 atgcagttga aaatgcattg aaagtagtag ggttacctta taaagacaaa aagttgttcg
    20281 gtaagtattc gctgggaatg aagcaacgtc ttggtattgc taacgctatt atgcacgacc
    20341 ctgaattact gattttagac gaacctacaa acggtcttga ccctattggg attgcagaag
    20401 taagagattt tattaaaaat ttgagtgttg agcatggaaa aacaatcctt atttccagtc
    20461 acattctttc ggaaatctca ttattggctg atgatattgg agttattgac catggtgttc
    20521 ttttagaaga aagtagcatg gaggaacttg gaaagaaaaa ccgcagctat ataatgttgc
    20581 aagtttcaga tattccgaag gcttcactga ttttagaacg agagttcaac ttgaaagatt
    20641 attctgttca agatgatcaa accctacgac tttatgacac tactctggat ataggtaaaa
    20701 taaataaagc ccttgtaatg cagaatataa ctgttattag ttcggtactg tgtcatgata
    20761 ccttagagga ctacttcaaa aaaattacag gaggtgaagg tattgcttaa ccttattcaa
    20821 acagaatttc ttaaactacg ccgcaataaa cttatttggc tcatgttgtt agccgctctt
    20881 attatgccgt ttttcgcact attatatttt aattattttg ggaataaagg tgttgacccg
    20941 ataaagtatt ataggtggtc agcacttggt tttactctta tcattatctt acctgttatt
    21001 ttgggaatac ttagtactat gcttatgcac gaagaaaatc agcatgatat gttaaaacaa
    21061 ctttggattg ttcctatcag caaaatggga tactttttta gtaaattttt tgtggtttta
    21121 gtttactcca tttgtttcat gctaattaca ttcgtagcct ctgttatgtt tagtgtactt
    21181 tcgggatatg ttgtatttga atgggggagc gtattttatt tgctgaaaaa atgtgtagtg
    21241 ggtggttttt ttactgcttt tgcaatgtta ccgattttag caatagcatc atcgaaaaaa
    21301 ggatatattc tcccagtttg tataacattg gtttatgttt tttttgcatt tcttataatg
    21361 cctgtaaata tgtatctaca ccccatatcc agtatgggag ttattgtaga tattccgggt
    21421 attgttcaag caattaacgt tccgttagcg tttctttgta tttgtgtttg ggatattatt
    21481 tcagtattct ttgcaaatat cgcattgaaa agaagtgagg tgtaaagaat gcgaaaatta
    21541 ctttgggctg aaatccaaaa gattcgccgt ttaaatattg tttggattgc agtttttgca
    21601 acagttatgg tagctgttat tgtttttata cagggatggg ttgcgtataa tgggtcacgt
    21661 gatatagaca gtgcaggatg gtatatgact atggctcagc ctttggcaac attttttgtt
    21721 cttcccgcag taatttctct tttgggaagt tatatgattt gtcgtgaaga agatgaggat
    21781 actataaaat ctttgctact tattcctgta aatgaaacaa agttaattgc tacaaaaatg
    21841 attattactt ttttattcag tatttttatt tatttactgc tatttgcaat agcatttttg
    21901 actgaggtaa tattacatct ttcagattta tcggtaggaa tggttttata ttttctgaaa
    21961 atatattttc ttcaaggtgt tggaatattc cttgctatct cgcctattat tgccttggta
    22021 tcatatatga aaaaaggcta ttggattgca ttagtattaa ctgaaatgta ctcttttgct
    22081 ggactattca tgagtatgtc aaacacccta aaaacattct atcctattgc tgcagtattt
    22141 ggggtttctg gttacactga agctactgcc caaagtcgga taggaagtat tataatcttg
    22201 ttactatgcg gttgcctttc agtttttata ctcaaaggtt tcagatatag tgaaaagaat
    22261 tagccatacg cttgagcgta tggctaaaag caatttctga ggacaaggct aattattttt
    22321 agagattaaa acctgtataa ctttaaaaaa tacaacagct caaaagataa cctggagatt
    22381 aataaaatga acagtgaata ctactaagtc taagttgtct attgatttca attggtatga
    22441 gatagttaaa aagtatgata aaaataattt aaaaaaactt taaaaataat ttattaataa
    22501 ttttaaaata aattattaat aaattatttt taaagtgttt tgaggtacaa taaaattgtt
    22561 agttaaactt ttgagaatat taataattac tttgaataga tattttaatt ttcgacaaga
    22621 aaataagtca aatagttaca acataactga taatgttcta acaataaact tggtcatgat
    22681 atgctgtaca aggagaatct ataaataatt ttaataaaat catttaataa aattatcgtt
    22741 aaaatattga tttataggta gaagtataag gggagtagta tgaaaaacta gtagttagga
    22801 ctttagaatt aaatttttat taaaaaggga ttatatggtt tgagagagct ttcagaaaat
    22861 ataataaact tgaaatttat atacgaatat atcgatttat gttaaaattt aattatcgaa
    22921 atcgaaaatt aaatgagaaa aagccaggag tgtaataagt ttggcgactt actcctgact
    22981 tttttataag tactctagat aagagagaac tctcatcaga gattttttac attgttatta
    23041 tgtattaata ctaacatatt aatactcaca tatcaatcat tttgatatgt aaaacaatgt
    23101 aaaaatttca tggcgacaac gactgtgtcc gttgcttaaa atataaatgc acacttttag
    23161 agagctctcc ttatctttag tattgattaa atcttataga tattattcga tttactaaac
    23221 atagaggaga tttttttatg gggatgaaag aattctgcga tcatttatat gatgatagca
    23281 cagatggata tatacaagtt ttaaagttaa atgatgaaaa aaataaaagt gagagaacta
    23341 ttaaaatata taatactaga catgaaggat taaaagatgt tgtagaagag ctgcatgagc
    23401 aaaatgatgt atttgtagct ccaaacacaa tgtacatacc taaaagaaga gtagaaaata
    23461 taagacaatt taggtcttta tttcaagata tagactgtga aaacttagga ttcgaaaaag
    23521 ctgaaacagt gtatcttata tgggaattat actatgaagg taaaatacca aaaccaacta
    23581 tggtaacaga tagtggaaga ggagtacatc tttattggag aatacaaaat gctccatatg
    23641 gagctttaaa tacatggcaa gagttacaag attatatata ttataatcta aagcatttag
    23701 gagctgatag acaagctaca gatagtgcaa gagtacttag attaccagga actataaatt
    23761 ctaagaatca agtcaattgt gaggttttat atatagatga tgagttagag tattctatgt
    23821 acgatttaag ggagaaatat ttaaactata gacctaagtc atatcaacta cagatggaag
    23881 atactaaagt agtagaaaat aaagttattt caaatagatt ttttaattca tatagtttac
    23941 atatgcaaag agctaatgac ttacaaactt tatgtagact tagaaaattt gatatgaaag
    24001 gctatagaaa tatggctatt cattgttatg catattggaa aggaatatat gtaagagatc
    24061 aatatgaact tgaaaaggaa gttatagagt taaataaggc atttaaagaa ccacttaaag
    24121 atactgaagt aaaagctgtt ttaagatgta ttccaaaagc tattgaaaag tttatagctt
    24181 atgaacaagg gttaagaagt ggagagaaaa aaagagtttc aaagggaatg agagataaag
    24241 aaggttattg gtataagaat actactttaa tagagcgatt aggaattact gcaaatgaac
    24301 aaaagcatat gaaaactata atcggaactg atgaaaagta tgaaagaaat aatgaaagaa
    24361 gaagagccga aagaagaaat gaagctggtt taactaaaaa gcaacaagaa ctacaagatt
    24421 taaaaataaa aattatgaag cttaaggaac aagggctaag caatagagct ataggaaaac
    24481 aactgaatat aagcgaagga aaagtacgaa caacacttaa aaagtaggtg cgtaaaaaaa
    24541 tggctcttta taaatatgtg gttgtgctgc tattcttttt ttatttagag tattgggttt
    24601 aaaattagaa gtattactag ctattacata aatgagtatt gaaaaataag tgcgtaaaaa
    24661 aatggctctt tataaatatg tggttgtctg tggaagattg ttgaataaga aaattgataa
    24721 agtgatagat atataaagta tattacatgg gagaatctat tgatgaatac agaggttgaa
    24781 aaaaataaaa tcattattta aatttgaggt atttgaatca gttatagaat ttttaaaaac
    24841 acaaaatgaa tataaagaac taaaagggaa tgtacaaggt aaaaacttta aattaaacca
    24901 atgtgatgag tttaatttag atactgtaga tggatatata gcgaataagt attatggagt
    24961 ctaagaagga gaaacttgga ctagacgagt aacctactat ggagctattt taaaagcttg
    25021 taatttaata actgatgaaa aaaaatatat tatttgtaga atacccatat aaataaattg
    25081 tataaaatca aggaaaaaga atataaaaat aattatagta tcctatcaca taaataaaaa
    25141 agaatgtatc atttgaagtt aattatattc aataaatata tccttttact tcttattatt
    25201 caattcatat atatttgaac taagtgaatt tatactagta ctcaaatttt caagtttacc
    25261 ttctattcta attaacaagt acattgtaac tatagcaggg aaccctaaat ttgacactaa
    25321 agtcattaaa tctagtttct atcgagttca ttccttcaat taaactttaa aattgattag
    25381 aacgcccttc agaaggtcaa agagacgttc atgtgtaagt catatccagt gtagttgcag
    25441 tttgaactac tttttcttct aaagctattt caagttcttc tcaaaatcta ggcgcaaata
    25501 catttttaac aactatttgg tccatagcct cttttatttc tgcttcagtt atatcttctt
    25561 tagaatatga tacaaacaag cttacttttc ttccaagata tgtagagaaa accattaatg
    25621 atctagtttc tatatttctc attttttaaa cctcctttct tgttttattt aagtaacggg
    25681 acactagcct tttccgagtg cacgttgacg acatgaagtg attcgtagat gtagtcgctc
    25741 aagcgaatcg aattttaatt tgcttgtgtt aattctgtat taaaaaatat tacgtttaaa
    25801 ttgaaattga attatatata atgttataat aatgctaaat aaaattaaaa ttaatttata
    25861 aataatttat taataaatta tttataaatc attaaaataa ggtggtattt atgaaaatat
    25921 gttcattttt caatgttaaa ggtggagttg ggaagactac tcttacaata cttacagcta
    25981 tgaaattgag taaagaagga aaaaaaattt tgttaataga tgcagataca caagcaaatt
    26041 taactcaatt tttatacaaa gtagttcatg atgataagac attatttcaa atgttaacag
    26101 aaaatacaac tgcaaaagaa gtaatattaa aatcacctgt agaggaattt aaaaatatcg
    26161 atataatacc aagtgatatt agcttaagtg ttttatcaga gtatttatca actcaaatgg
    26221 gaagagaaag agcagtatgg agatggttta aaaataatat agatgatata gaaaagtatg
    26281 attatatatt tgtagattta tcaccatcgt atgatcttat agctagaaac tttatgttaa
    26341 tatcagattc tataattaca cctattgagt accaagatat tgcatcaata agagggtgtg
    26401 aactatttta tcaaaaattt aaacaagatt tagagttttt agatattaaa tcaaatacta
    26461 aaagagctgt agttataaat tcctatacaa ctagaaaatt aagtacagga gatctattta
    26521 attcttatct agataaattt gaaaatataa aaacagattt attacaagct agaataagtg
    26581 aaacaacagt tgttagaaat gctattttaa ataaaatgga tttagaagat tattgtagga
    26641 aaattaaaaa agctcataaa gttagaagtg actttaatga gtttatagaa gagttaaagg
    26701 ctaaggaggt tttatagatg gctttagata tatttaaaga agatgtatct gatataaaaa
    26761 taagaaaaaa tgactatcaa aacaaagtgg attcaattat agaggatact ttagatatag
    26821 atattgaggg tgtaaactta cttgatatga aagaagaaaa aaaagcaaaa aaaatacctc
    26881 ttacaattta cttagaagaa gaagaattag aaatattaaa atctgtatct gttctgaaaa
    26941 acacaacagt tcaaaagaca atagggaatt tagtaaaaag tactgtaaat actactaaag
    27001 ctaatttacc tagtgatttc aatatacatg atatggttaa aaaatataat aaagaaaata
    27061 aagtaaaaaa aaataaaaaa taatttataa ataatttata tgtaatttat ttatgcatta
    27121 cgtataattt aaaactaact tattaaaaag aatattttaa taagttaatg cgatgaaaaa
    27181 tggctcttta taaatatgtg gttgtgtcta cgaagggtct ttatgctttt aagtagttta
    27241 tttagtagga atattacact atttgtagaa tatcattata actaagtttt tttataggag
    27301 gatattttat ggatttaaaa atgagtgatc tacctccaca atttgaaaat atagctatgg
    27361 aaattggaat agatagagta aaggctttat ttaaagaatt tggagggaca tctgtgtact
    27421 ttcctactga aaagatgata tataaagatg ctcgtgatag agagattata gaagagttta
    27481 atggatttaa tgtaaaggca ttagctagta agtatagaat gtctgaaagt tacgttagag
    27541 ctattattcg taaaaataaa taatcaagtt gaaaatttat gattttaatt gtattattag
    27601 gacttaaata aagttttaga tttttaacaa aatgctaata aaaagagctc cataatctat
    27661 ttttagatat ggagtctttt ttttatttt
//
