LOCUS       NZ_CABIWO010000001     12265 bp    DNA     linear   CON 29-FEB-2024
DEFINITION  Paraclostridium bifermentans isolate MGYG-HGUT-00024, whole genome
            shotgun sequence.
ACCESSION   NZ_CABIWO010000001
VERSION     NZ_CABIWO010000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Paraclostridium bifermentans
  ORGANISM  Paraclostridium bifermentans
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Paraclostridium.
REFERENCE   1
  CONSRTM   EMBL-EBI Metagenomics Team
  TITLE     Direct Submission
  JOURNAL   Submitted (06-AUG-2019) EMG, The European Bioinformatics Institute
            (EMBL-EBI), Wellcome Genome Campus, CB10 1SD, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/29/2024 00:21:00
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,602
            CDSs (total)                      :: 3,499
            Genes (coding)                    :: 3,477
            CDSs (with protein)               :: 3,477
            Genes (RNA)                       :: 103
            rRNAs                             :: 11, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 5, 2 (5S, 23S)
            tRNAs                             :: 84
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 22
            CDSs (without protein)            :: 22
            Pseudo Genes (ambiguous residues) :: 0 of 22
            Pseudo Genes (frameshifted)       :: 2 of 22
            Pseudo Genes (incomplete)         :: 13 of 22
            Pseudo Genes (internal stop)      :: 7 of 22
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 02:03:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1960837
            Orig. end                         :: 1973102
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CABIWO010000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..12265
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="5"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..12265
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..12265
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:7265](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..7265)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            155..397
                     /locus_tag="FY209_RS09285"
     CDS             155..397
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FY209_RS09285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_148551146.1"
                     /transl_table=11
                     /translation="MNENNRKNLKRFLPLSLCCIIPILLLLAVPLISSYSVSSALAVSF
                     IAPFICPIVMGGALFFIFKGNKSCCSDKSSNTIEK"
     gene            complement(539..886)
                     /locus_tag="FY209_RS09290"
     CDS             complement(539..886)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015798.4"
                     /locus_tag="FY209_RS09290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="four-helix bundle copper-binding protein"
                     /protein_id="WP_148551147.1"
                     /transl_table=11
                     /translation="MGIVTNKTDKHQACIDECQKCAQACYECFNECLNEPDLKERKNCV
                     STLVECAMMCQMSVSMMAMNGKFSKEHCELCAKICEQCEQECAMFKDDHCQKCASVCRL
                     CADECRKMANM"
     gene            1128..1274
                     /locus_tag="FY209_RS09295"
     CDS             1128..1274
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF022597.4"
                     /locus_tag="FY209_RS09295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF2922 domain-containing protein"
                     /protein_id="WP_148551148.1"
                     /transl_table=11
                     /translation="MIFSTTLGRKVSLFVSDPREDLTEEEIKAAMEQIVEKNIFAPRFG
                     EEL"
     gene            1411..1566
                     /locus_tag="FY209_RS09300"
     CDS             1411..1566
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018591228.1"
                     /locus_tag="FY209_RS09300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YvrJ family protein"
                     /protein_id="WP_148551149.1"
                     /transl_table=11
                     /translation="MELDLMTLVSNLGFPAIVTMYLLIRIEGKLENLSNSINSLSNNIY
                     ELNNKK"
     gene            complement(1933..2250)
                     /locus_tag="FY209_RS09305"
     CDS             complement(1933..2250)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FY209_RS09305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_148551150.1"
                     /transl_table=11
                     /translation="MDMSLDNNEFNKKLIEDSVKSQEKLSIVNLLCTTLICSGPTGCLI
                     LRILDNETDKLLLTALCAIPTLIYMTWSWSSFFYNRKIDKELKELEELVDKYERKIYKG
                     K"
     misc_feature    complement(2379..2390)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.03"
                     /tool="antismash"
     misc_feature    complement(2592..2606)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 17.06"
                     /tool="antismash"
     misc_feature    2981..2996
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 23.71"
                     /tool="antismash"
     gene            complement(2983..3342)
                     /locus_tag="FY209_RS09310"
     CDS             complement(2983..3342)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FY209_RS09310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_148551151.1"
                     /transl_table=11
                     /translation="MSGFALRRNLGLQLPTSFVEIESNEMEYIDGGGFIGFRVHFSKKV
                     QNMGAVAGGAFVGGVVGFACKSLAATGPIGAGAAATISAVAGGVAGNAIRKGLSAVNIG
                     VHANGVKSNIKHLYV"
     gene            complement(3418..4530)
                     /locus_tag="FY209_RS09315"
     CDS             complement(3418..4530)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1029: RND family
                     efflux transporter MFP subunit"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF024829.4"
                     /locus_tag="FY209_RS09315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_148551152.1"
                     /transl_table=11
                     /translation="MKVYNLNEITNSRLLYDKEPPKFLNFVILTVLALIIGFIIWSTNS
                     VKTFIVKGQGIVSNKEKSTIMAKVSGEIDKVFIEEGTIVKKGDLLLSINAPDIKYQLSQ
                     VNDQIDLLEEKINLLKRAERNATNKSNNFSKDNSYEVEFYNKLKLSSSKIEEYRVDEKS
                     LKKQNYSKDQINQLKKQSKIKENQIYYETISEFTREKMQLDLELNKLKSQKKALSNSSE
                     DYKLYANQSGTIHLNDDIKEGMFVQAGTAFGNISNKNKGIIVTSMIQGSDRPRIHKNDE
                     VSLIVGGLNQTDYGTLDGKVISIDEDSTIDSEKGNILFKVKVKPEKTYLKDKKGERVNL
                     TSGMIVETRVKYENITYANYLLDQIGIQFN"
     gene            complement(4517..5014)
                     /locus_tag="FY209_RS09320"
     CDS             complement(4517..5014)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FY209_RS09320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_148551153.1"
                     /transl_table=11
                     /translation="MNTIEKITIRENKTLKLRNVLSRELKEDELVHMDKVTYMMENYIK
                     SKGNSTIGPMVTYSSSLVDEHGNLTVKSKIMIQLRNKINKVENPYKIEEEVRVTNCLFA
                     RYNESEENLQYAYSKLELYAFENDINLKGDAYTVFVDNKDYKLVADVFMEVQKEDLSFE
                     SL"
     gene            complement(5001..7265)
                     /locus_tag="FY209_RS09325"
     CDS             complement(5001..7265)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR01193.1"
                     /locus_tag="FY209_RS09325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_148551154.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.9e-39, bitscore:
                     131.5, seeds: 36, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR01193 (E-value: 8.7e-192, bitscore:
                     636.2, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNYKKYLIKQHDSSDCAAACLAMICMYYKKDISITKLRDVLGTD
                     IKGTTLKGLESGANKLGFDTKAIRVDKESFQSKYTLPAIAHVVTDEGLEHFVVINKIKK
                     DKVTILDPDKGYQKKHINDFFNNFDGIMLLMIPNNEFEKGKDKKGKTLSMFINLLLPQK
                     KLFIYSIITSIILTALGITSSFFNKFLMDEILPYALKNQLKAFIIGFLLVGITQIILSA
                     IRQHMLLYLSQKIEIPLLLGYFKHIYKLPMNFFSSRKVGDILTRFSDAFTIKDILTSVS
                     LSLIIDIGLATSTATILYLMNSTLFIIILTLTIINTALIYIFKEPYKKINLDQMEAESR
                     LNSNIIESLKGIETLKSLGAEDKSLEKLEDEYIKNLKIAFKEGVFSNIQGSISSGVSTV
                     GNLVLMFIGANLVMDGKITLGSLMAFTSLSGYFMEPIGRLIGLQLSIQEASISLKRISE
                     IYEVEKEQTIDDKVKIESIDGDIEFKNITFKYGNREPVLKDVSIKIPKGKKVALVGESG
                     SGKTTLSKLLLKYYIPESGKIQIGDYDIEELDIYSLRKSVAYVPQNIELFSGTIKENIL
                     LGASGITEKELKYACENAGCSNFINRLPSKYDTFLDESGGGLSGGERQRLAFARAIVKK
                     SKFLILDEATSNLDFISEAKIYNTLFVKGENTTMLIIAHRLSTIRNCDFIYVMDKGKVV
                     EVGDHNTLLSKKGYYYKLYISQVGELNDIDINDKKQYSIKDIEKDEYTLEVDEGEEYEY
                     Y"
     gene            complement(7413..8153)
                     /locus_tag="FY209_RS17960"
     CDS             complement(7413..8153)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025854.4"
                     /locus_tag="FY209_RS17960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding protein"
                     /protein_id="WP_187359421.1"
                     /transl_table=11
                     /translation="MIFSKIYIFNIVKKNIENYKLEYENKIIKDNVLKEYNYYLEVSKE
                     KNNVKSLYHDIKNHMICIRSLCEKNNIEKIIEYIDSMENNVNTYNQLNQDFNTGNMILD
                     SILKNKKTICIEKDIKFVSEIDFSKNDFMDMVDVCTIFSNLIDNAIEACEKINESNIDK
                     RIILKSKYIDGFCIILIENTKTNEIKQRKNLFLTHKEDSYMHGIGLSNVKKTVEKYFGE
                     AIFNYSKNIFSVKIMIPLEKSSTN"
     gene            complement(8744..9454)
                     /locus_tag="FY209_RS09335"
     CDS             complement(8744..9454)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012301.4"
                     /locus_tag="FY209_RS09335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_187359422.1"
                     /transl_table=11
                     /translation="MNLSVAICDDEPIHRNLLLNYLNQVFYNESYEVLEFEKGEELLEN
                     YPEKLDILLLDIQMGGLNGIETAKKIRQFDTNVIIIFTTAVFDFIQQGYEVRAFRYLLK
                     PISYDEFSRHLIECKNDITNEIKKNIKIKETTEGSISIIPISSILYIETVSRVTLIHTD
                     KKIYKTRESIKNLENELENHLFYRCHRSYLINLHKVSSINKGSVYIKNDEILVSRYKIK
                     DLKLRITNTLGSLL"
     misc_feature    complement(10399..10410)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 19.78"
                     /tool="antismash"
     gene            10466..11524
                     /locus_tag="FY209_RS09340"
     CDS             10466..11524
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1158: ornithine cyclodeaminase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF005762.0"
                     /locus_tag="FY209_RS09340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ornithine cyclodeaminase"
                     /protein_id="WP_226888266.1"
                     /transl_table=11
                     /translation="MRGVKMETLKTRYIDLPTMAKYLKKVGPETVMKRLVPYLESDYKR
                     WNEFQKMPRTAHHSDIGVLELMPIGDSETYSFKYVNGHPENPKHNYLTVMGIGLLAEVS
                     TGFPLFLSELTLTTAIRTAATSVMAAKYLAKPNPKKMALIGNGCQSEFQALAFHHILGI
                     EEIYCYDVDPEATSKLMDNLKDVNNLKLIKCNSTKEACKGVDIITTVTADKRNAIIITP
                     DMVEPGMHINGVGGDCPGKTELDSEVLNMGDVYVEFEPQSRIEGEIQHMDENFKVTEIW
                     NVIKTGKPIDRNPDEITIFDSVGFALEDFSILRLMYDIDKEENIGVPQILVPKLENPKN
                     LYSLLGNKALNV"
ORIGIN
        1 tttcatatta ttttcactct aatgataatt aaataatgtg aataaaatat gaataaatga
       61 taaaaaagta aaaataaatt tttatattta atttcataat taattcataa ttttaaatta
      121 aaattaccat ataaaattta tggaggtaat tcaaatgaat gaaaacaata gaaaaaattt
      181 aaaaagattt ttaccactct ctctgtgttg tataattcct atattattgc ttcttgcagt
      241 tcctttaatt agttcatata gtgtttccag tgcattagct gtatcattta tagcaccctt
      301 tatatgccct atagtcatgg ggggagcatt gtttttcata tttaaaggaa ataaatcttg
      361 ttgttctgat aaaagctcaa atactattga aaaatagata atttaaaact tataaaatag
      421 ggtgacatag cgtgtttaat aaattattta taggtatcga atattacttt tcatcaagta
      481 ttaattatcg attgtaaaaa atccattcta tttataaata gaatggattt tttgctaatt
      541 acatattagc catttttctg cattcgtctg cacataaacg gcatacactt gcacattttt
      601 ggcagtgatc atctttaaac atagcacatt cttgctcaca ttgttcacaa atcttagcgc
      661 ataattcaca atgttctttc gaaaattttc cattcatcgc catcatcgat actgacattt
      721 ggcacatcat agcacattca actaaggtac tgacacaatt ttttctttct ttaaggtccg
      781 gttcatttaa acattcatta aaacattcat aacatgcttg agcacatttt tgacattcat
      841 ctatgcatgc ttgatgttta tctgtcttat tcgttactat acccattgtt aagcctccta
      901 aaatttcatt gtttttctaa ttaggttctg taattaaata aatttttata catgctttat
      961 gtatcttact atactgttta aaaatcaaaa ctacctaatt aaacttcgta ctataatctc
     1021 tataatacct ctttactcat ttcaattagc ctactttcct atgaactaat caaaattaaa
     1081 aagttattca acttcttttt cgtaaattat tagaatctag attattaatg attttctcta
     1141 caactcttgg aagaaaagta agcttatttg tttcagatcc tagagaagat ttaactgagg
     1201 aagaaataaa agctgctatg gaacaaatcg ttgaaaagaa tatatttgct cctagatttg
     1261 gtgaagaatt ataagctcca ttagaagcaa aagtagttca aactacaact actggatatg
     1321 acttagttat atagtttaca tgaagccctt ctaaaattta gaggggtttc ctaataatat
     1381 ttttaatttt attggaggta tatttattaa atggaattag atttaatgac tttagtatct
     1441 aatttaggtt ttcccgctat tgttactatg tatctactaa ttagaataga aggtaaactt
     1501 gagaatctaa gtaatagtat aaattcattg agtaataata tatatgaact taataataag
     1561 aaataaaaaa atgtacctaa taaaagttaa gtaggtacat ttttttattt aaaacattta
     1621 ttaattattt ttaaaaattt tacttctaaa gtattttata cctttaggta aataagtact
     1681 ataatatgat taaaaatata ttcattatca agaaaataag aaataaccct agaatcaatt
     1741 catataaata aaatccagct acataaaaac atatgaacct caataagtaa aattagcaat
     1801 gcagaaataa ttttaaatca aattatttct gcattgtttt aatttaatat tgatttattt
     1861 tttattcctt ttcatatgct acatttttag ttttaaatag atattctatt aatatcatat
     1921 ctatttaaaa acttatttac ccttatatat ttttctttcg tacttatcta ctaattcctc
     1981 taattctttt aattccttat ctatcttacg attatagaaa aatgaagacc atgaccatgt
     2041 catgtaaatt aatgttggaa ttgcacaaag tgcagtaagt agtaatttat cggtctcatt
     2101 atctaatatt cttaaaatta aacaccctgt tggtccacta catataagag ttgtacataa
     2161 aagattaaca atagataatt tttcttgtga cttcacacta tcttcaataa gttttttatt
     2221 aaattcatta ttatccaaag acatatccat catttctccc atctgcacga tcaaattttc
     2281 atgtaataca aactcctatg tctacacatt cgaagttccc gattttatag atattcctat
     2341 aacgactttc tatgggattt tataattaac ttagtttaga tatctttttc atatttatat
     2401 taggatatca tcgatatcac tttatatgtt ccatcaataa catttcaaat cgctactggc
     2461 ttatctatta tttaaagtat gaaaggatta agttaacaaa tctaaactta atcctttctc
     2521 tttaatagat aattaacttt aaagtacaga cttattttta taagagttta ttataaaata
     2581 cttttaatca tatgtaagtg ctcttactat ttgctgtttt taacaaatta aataataata
     2641 acctgtagat aaataaacta aatacaatca taccaataag atcaattaaa ttaaaattat
     2701 catagtaaat atatatatta aatactgata gtgacaataa aaaggaactt attaactcat
     2761 aaatattttc tttcgtcaaa gtgtacttaa aagttgttat attaaaagta gaattaaggc
     2821 tatctgatat tacaccttta tataatccta gcattcctcc cataatcata aatggtatca
     2881 tactttccat attaaattta atgccaaaat aaaagactat aatattaaaa acaattgata
     2941 tacttataag aatcatctat ttattcctcc taatgttaaa atttacacat ataaatgttt
     3001 tatattactt ttaacgccgt tagcatgtac acctatattt acagctgaaa gacctttacg
     3061 tatagcattt cctgcaactc cacctgctac agcactaatt gtagcagcag ctccagctcc
     3121 aataggacct gtagccgcta gacttttaca tgcaaaacct acaactccac ctacaaatgc
     3181 tcctcctgct acagctccca tattttgtac ttttttagag aagtgtactc taaatcctat
     3241 aaatccacca ccatcaatat actccatttc attactttca atttcaacaa agcttgttgg
     3301 taattgtaat cctaaatttc ttcttaatgc aaatccactc atttctaaat ctccttttgt
     3361 gtatatatat tttttattta tatcaaaggt atctgcagcc acctttaaat aacaagatta
     3421 attaaactgt atacctattt gatctaataa atagtttgca taggttatat tttcatattt
     3481 aactctagtt tcaacaatca tccctgaagt taaattaact ctttcacctt ttttatcttt
     3541 taggtatgtc ttttcaggct taaccttaac cttaaaaagt atattgcctt tttcactatc
     3601 aatagtcgaa tcttcatcta ttgaaataac tttaccatct aaagttccat aatcagtttg
     3661 atttaatcct cctacaataa gggaaacttc atcattttta tgtattcttg gtctatcact
     3721 accttgtatc atagaggtta caataatacc tttattttta ttagaaatgt ttccaaaagc
     3781 tgttccagct tggacaaaca ttccttcttt tatatcatca tttaaatgta tagttccact
     3841 ttgatttgca tataatttat aatcttcact agaattagat aaggcttttt tttgactttt
     3901 taatttattt aattctaaat ctaattgcat tttttctctt gtaaactcac ttattgtttc
     3961 ataatatatt tgattttctt ttatttttga ttgtttctta agctgattta tttgatcttt
     4021 tgaataattt tgttttttca aggatttttc atctactcta tactcttcta tttttgaaga
     4081 acttaatttt aatttattat aaaattctac ttcataagaa ttatctttac taaagttgtt
     4141 acttttattt gtagcatttc tttccgctct ttttaaaaga ttaatttttt cttcaagtaa
     4201 atctatctgg tcatttactt ggcttaattg gtacttgata tctggagcat taattgaaag
     4261 taataaatct ccctttttaa cgatcgttcc ttcctcaata aatactttat ctatttctcc
     4321 agacacttta gccattatag tacttttttc cttattactt acgattcctt gacctttaac
     4381 aataaatgtt ttcacagaat ttgtactcca tattataaac cctataatta aagctaaaac
     4441 tgtcaaaatt acaaagttta aaaatttagg cggctcttta tcatataata atctgctatt
     4501 tgttatctca tttagattat aaactttcaa aagataggtc ctccttttga acttccataa
     4561 aaacatcagc tactagttta taatctttat tatcaacaaa tacggtgtag gcatctcctt
     4621 taaggtttat atcattttca aatgcgtaca attcaagttt tgaataagca tattgtaaat
     4681 tttcttcgga ttcattatat ctagcaaaaa gacaattagt aactctaacc tcttcttcta
     4741 tcttatacgg attttctacc ttattaattt tgtttcttaa ctgaatcatt attttagatt
     4801 ttacagttaa atttccatgc tcatcaacta atgaagatga gtatgtaacc attggtccta
     4861 ttgtactatt tccctttgat tttatataat tctccatcat ataagttact ttatccatat
     4921 gtacaagttc atcttctttt aactctctac taagcacatt tctcaatttt aatgttttat
     4981 tttctctaat agttattttt tcaatagtat tcatactctt ccccttcatc tacttctaat
     5041 gtgtactcat ctttttctat atcttttatt gaatattgtt ttttatcatt aatatcaata
     5101 tcatttaatt caccaacttg acttatatat aatttatagt aatatccttt tttacttaaa
     5161 agtgtattgt gatctccaac ttctacaact tttcctttat ccataacata tataaaatcg
     5221 caatttctaa ttgtagataa tctatgtgct attattagca ttgtagtgtt ttcacctttt
     5281 acaaatagtg tattatatat ttttgcttcg cttataaagt caagattact tgtagcttca
     5341 tcaagtatta aaaacttcga ttttttaact atagcccttg caaaagcaag cctttgtctt
     5401 tctcctccag ataatccgcc acctgattca tccaaaaaag tatcatattt agacggtaat
     5461 ctatttataa aattactgca cccagcattt tcacatgcat actttaactc tttttccgtt
     5521 atccctgatg ctcctagtaa tatattttct tttattgttc ctgaaaatag ttctatattt
     5581 tgtggaacat aagccacaga ttttcttaaa ctataaatat ctaattcctc aatatcataa
     5641 tcgccaatct gtattttccc actttcagga atatagtatt ttaatagcaa ttttgataat
     5701 gtcgttttcc cactacctga ttcaccaact aaagctactt tttttccttt aggtattttt
     5761 atgcttacat cctttagtac cggttctcta tttccatatt taaaagttat atttttaaat
     5821 tctatatctc catcaataga ttctattttt actttatcat ctatagtttg ttctttttct
     5881 acttcatata tttcagaaat tctttttaat gatatacttg cttcttgaat acttaactgc
     5941 aatcctataa gccttccaat aggctccata aaatatcctg atagtgatgt aaatgccatc
     6001 aaactcccta atgttatttt tccatccata actaaattag cacctataaa cattagtact
     6061 aaatttccta cagttgagac acctgaagat atactgcctt gtatattaga aaagactcct
     6121 tctttaaatg caatttttaa attttttata tattcatcct caagtttttc taagctttta
     6181 tcttctgctc ctaatgattt tagagtttct atacctttta aactttctat aatattgcta
     6241 tttaatctag attctgcttc catttgatct aaatttattt ttttataagg ttctttaaat
     6301 atatatatta acgcagtatt tataattgtt agagttaaaa ttataataaa taaggtacta
     6361 ttcattagat ataatattgt agctgtagat gttgctagcc ctatatctat tattaacgat
     6421 aaagaaacag atgttaaaat atctttaata gtgaaagcat cactaaatct tgttaatata
     6481 tctccaacct ttcttgatga aaaaaagttc ataggcaatt tgtatatatg cttaaaatat
     6541 cccaacaata aaggaatttc tattttttga gataaatata gcaacatatg ctgtctgatt
     6601 gcagataata taatttgagt aatacctact agtaaaaatc ctataataaa tgctttcagt
     6661 tgattcttta aagcatatgg tagtatttca tccattaaaa atttattaaa aaacgaagat
     6721 gttattccta gagctgtaag aattattgat gttattatgc tatatataaa taactttttt
     6781 tgtggtaaaa gcaagtttat aaacatagat aaagttttac cttttttatc ttttcctttt
     6841 tcaaactcat tatttggaat catcaataac attatcccat caaagttatt gaaaaaatca
     6901 tttatatgct ttttttgata tcctttatct ggatctaaaa tagtaacctt gtcttttttt
     6961 attttattta taactacaaa gtgctcaagg ccttcatcag taacgacatg agctatagca
     7021 ggcaacgtat atttactttg aaaactttct ttatcaaccc taattgcctt agtatcaaaa
     7081 cctagtttat ttgctccact ttctagtcct tttaatgtgg tccctttaat atcagtacct
     7141 aagacatctc ttagttttgt tatgctaata tctttcttat aatacatgca tatcatggca
     7201 agacaagctg ctgcacaatc tgaagaatca tgctgtttaa ttaaatactt tttgtaatta
     7261 gtcaaatttc gagctctctt tctatttaaa attattaatt taataaagat tcttaaattt
     7321 tatatttata tagatatcat aaaaaaaata ttaattaaat atataatgta tgaatagtta
     7381 attattttga ttgaatggta aaaaaagtag cactaattag tgctactttt ttctaaagga
     7441 atcataattt taacagaaaa aatattttta gaatagttaa aaattgcttc tccaaagtat
     7501 ttttcaacag ttttctttac attgcttaat ccaattccat gcatataaga atcttcttta
     7561 tgagttaaaa ataaattttt tctttgttta atttcatttg ttttagtatt ttcaattaaa
     7621 ataatacaaa acccatctat atatttactt tttaatatta ttcttttatc aatattagat
     7681 tcatttattt tttcacaagc ctctattgcg ttatctatta aattagaaaa tatagtacat
     7741 acatccacca tatccataaa gtcattttta gaaaaatcta tttcactaac aaacttaata
     7801 tctttttcta tgcatatagt ttttttgttt tttaatattg aatctaatat catattgcca
     7861 gtattaaagt cttgatttaa ttgattataa gtattaacat tgttttccat actatctata
     7921 tattctatta ttttctctat attatttttt tcgcataaac ttcttatgca aatcatatga
     7981 ttttttatat catgataaag tgactttaca ttatttttct ctttactaac ttctaagtaa
     8041 taattatatt cctttagtac attatcctta ataattttat tttcatattc taatttatag
     8101 ttttcaatat tttttttaac tatattaaaa atatatattt tggaaaatat cactagtatg
     8161 ggaaataaaa ccattaataa tatgtgatat ttcaccaaac ttttatctat cgcaattaat
     8221 ctgaaagtca aaattatagt tattatattt attaagatag gtatgcatat aaatatgtac
     8281 tttatctttt ttaatttata aaaacttttt atatgggtta aaatataggt aacgactaac
     8341 ataagtataa tttgaattaa catactctct atttcaattt tcattgaatt tacatggaaa
     8401 ttttgagtta gcctattata atttatatga aatgctaatt ctaaactaat atattcaata
     8461 ggtatatata cgcaaaacca atagattaag ctaaatatag tacattttaa aacattttgc
     8521 ttataattga ttttataaaa aacactgcaa ataaatataa atgttataga cctttcgaac
     8581 ttaaaaataa agataataat agatgtaaaa ataataatta tatagttaat tctattactt
     8641 aattttttac tacttaattt atctaatata tatttaaacg ctagtaaata cactagtata
     8701 gttattaagc ttactatata aaaaatatag ttgtgcgcac ttatcataat aaacttccta
     8761 gagtatttgt tattcttagt tttaaatctt ttattttgta tctgcttact agtatttcat
     8821 cattttttat atatactgaa cctttattta tgctactaac tttatgtaga tttattaagt
     8881 atgatctatg gcatctgtaa aacaagtgat tttccaactc attttcaaga tttttaatac
     8941 tttctcttgt tttatatatt tttttatctg tatgtattaa tgttactcta gatactgttt
     9001 ctatatataa tatagaactt ataggaataa tactaatact cccctctgtt gtttctttta
     9061 tctttatatt ctttttaatt tcattggtga tatcattttt acattcaatt aaatgtcttg
     9121 aaaactcatc atagcttatt ggttttaata agtatctaaa tgctcttact tcatatcctt
     9181 gctgtataaa atcaaaaaca gcagtagtaa aaattataat tacgtttgta tcaaattgtc
     9241 ttattttctt agccgtttcg ataccattta acccacccat ttgaatatct aacaacaaaa
     9301 tatctaattt ttcaggataa ttttctaata gttcttcccc tttttcaaat tccaggactt
     9361 cataagattc attataaaat acctgattta aataatttaa caataaattc ctatgtatag
     9421 gctcatcatc acagatagct acacttaagt tcataaagct ctcccttcta aacatgcact
     9481 aattattaat taatatctaa atttcactaa acaatctatg taattgttgt agtattttaa
     9541 aacacaaaaa aactcattat tttaatgtga tttaaaacta cggataatga gattttttaa
     9601 aatttattta tataccccta aaacatatta ataattaatg tttatgaaaa taataaacat
     9661 taattatgaa aattcgttct tacctagatt tttctatata aagataagag ttatcctcta
     9721 agcttattaa gcttaaattt ttattttgct ttaaatagca tctactatgt taacataatt
     9781 ttccaaatga tacactattt cagatattta tatacgtaca atttttttat aacttaacta
     9841 aattaatttt aactatttac taatattttt aaaaataatt tttctatttc aatattggga
     9901 cttactatat ttgcagttac tagttacaat agtgaataaa attaaaaatg aataaataat
     9961 ctaaaatcaa actatttcct tattatttaa atttaatatt tatttctggt tatgcctgtt
    10021 ttaaagttgt ttataataaa tattttatat tgtcaacttc taaaaataac attgtaaata
    10081 taattactta taattaaata attaacattt catcctatat ttagtaaata tctttaagat
    10141 ttatccataa acactataat taagctttct ccccttaaac aagtcatcta ttaaaagtac
    10201 cttagctctt ttatatctac taataatcct ttcatattct tcactatcca ttacattttg
    10261 tttaattcta gttatagctt ctcgataaga catatataat caggatgata tagttgattt
    10321 tgccaaaaac aacctactaa ttagaatact tttcaataat gattgaaata aatctaatgg
    10381 attgctataa tcattcttga aagcgttttc tcaataattg aaaatttaga tcttgaaagg
    10441 tctgcattat taaattaaaa attatatgag aggtgttaaa atggaaacat taaaaacaag
    10501 atatattgat ttgcctacta tggcaaaata tttgaaaaaa gttggcccag aaactgttat
    10561 gaaacgtctt gttccatatc tagaaagcga ttataaacgt tggaatgagt ttcaaaaaat
    10621 gccaagaact gcacaccata gtgatatcgg agtacttgag ttaatgccta taggagattc
    10681 agaaacttat tcatttaaat acgtaaatgg acatcctgaa aatcctaaac acaattattt
    10741 aacagtaatg ggtatcggtc ttttagcaga agtatcaact ggattcccac tatttttaag
    10801 cgaattgaca ttaacaacag ctattcgtac agctgctact tcggtaatgg ctgcaaagta
    10861 cttagctaaa cccaatccaa agaaaatggc actaattgga aatggttgcc aaagtgaatt
    10921 tcaagccctt gcttttcatc acatattagg tatagaagaa atttattgtt atgatgtaga
    10981 cccagaagct actagtaaat tgatggacaa tctaaaagat gtaaataatc ttaagttaat
    11041 aaaatgtaat agcacaaaag aagcatgcaa aggtgttgac attataacaa ctgttactgc
    11101 tgacaaaaga aatgctataa ttattacccc agatatggtt gaaccaggta tgcatataaa
    11161 tggggttggt ggagattgcc ctgggaaaac tgagctggat tcagaagttc tcaatatggg
    11221 tgatgtctat gttgaatttg agcctcaaag tcgtatagaa ggagaaattc agcatatgga
    11281 tgagaacttt aaagtgactg aaatttggaa tgtaattaaa actggaaaac ctatagatag
    11341 aaatcctgat gaaattacta tttttgactc agtaggtttt gctttagaag atttttcaat
    11401 tttacgatta atgtatgaca ttgataaaga agaaaatata ggagtacctc aaattcttgt
    11461 cccaaaattg gaaaatccta aaaatttata tagtctgtta ggaaataagg ctcttaacgt
    11521 gtaacaattg aagtaaaaaa cattctgctg aaaagtggaa tgttttttta ctgtaactta
    11581 taacatctat ttcatgttca ggaaaatatt tgttttattt cttgaatatt tcgtattaat
    11641 ttagatatat ttattacatt taaattttta aataatagcg gttcctactt gtcctaaaaa
    11701 tattattaaa ttttttctag tatttttaat gtccttgaat ctattgacat atcgattagc
    11761 ttttttataa gcttctacta ctttaatgtc ttatgtataa tcgaagtttt caaaagtctt
    11821 tttcctaaat tcattactta atttttactt tttttaccaa ttatatatct aaattactaa
    11881 taatatgcta ttgtgaatat tgtaatttaa ataatttatg tttttgtgtt atgtagagga
    11941 gtatgatgaa taaaattttt ttgataacct tatttttaag cttattatac ttacatcata
    12001 ttgatatttc taatgtgtct ataatggata ttttagtatc agcaattata atatttaact
    12061 tatttttaat taacgagttt agaaaaatca ataaaaagga aaaaggatct agttgaacta
    12121 gatccttcat tcttattttt tatcttaatc aataaatatt tatctatgtt taaatttatt
    12181 ttttattttg agtctattat ttctttagcc atttgtacta aatcatcttt agttaaatca
    12241 gagtcagttg ctaaaaatga ataat
//
