LOCUS       NZ_CABIWO010000001     20785 bp    DNA     linear   CON 29-FEB-2024
DEFINITION  Paraclostridium bifermentans isolate MGYG-HGUT-00024, whole genome
            shotgun sequence.
ACCESSION   NZ_CABIWO010000001
VERSION     NZ_CABIWO010000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Paraclostridium bifermentans
  ORGANISM  Paraclostridium bifermentans
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Paraclostridium.
REFERENCE   1
  CONSRTM   EMBL-EBI Metagenomics Team
  TITLE     Direct Submission
  JOURNAL   Submitted (06-AUG-2019) EMG, The European Bioinformatics Institute
            (EMBL-EBI), Wellcome Genome Campus, CB10 1SD, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/29/2024 00:21:00
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,602
            CDSs (total)                      :: 3,499
            Genes (coding)                    :: 3,477
            CDSs (with protein)               :: 3,477
            Genes (RNA)                       :: 103
            rRNAs                             :: 11, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 5, 2 (5S, 23S)
            tRNAs                             :: 84
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 22
            CDSs (without protein)            :: 22
            Pseudo Genes (ambiguous residues) :: 0 of 22
            Pseudo Genes (frameshifted)       :: 2 of 22
            Pseudo Genes (incomplete)         :: 13 of 22
            Pseudo Genes (internal stop)      :: 7 of 22
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 02:03:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 69643
            Orig. end                         :: 90428
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CABIWO010000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20785
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     cand_cluster    1..20785
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20785
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10785](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10785
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     misc_feature    25..40
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.2"
                     /tool="antismash"
     gene            487..1617
                     /gene="spoVE"
                     /locus_tag="FY209_RS00335"
     CDS             487..1617
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="spoVE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426995.1"
                     /locus_tag="FY209_RS00335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="stage V sporulation protein E"
                     /protein_id="WP_148549744.1"
                     /transl_table=11
                     /translation="MPKEIVKKRVSRGIKTDFDNVVFYTTMLLVFIGIIMVFSASFIQS
                     TFKLDDSYFFLKRNIIYATIGFIAMIFTSRIDYRFWYKNAKILGIVVVVLLLLVLSPLG
                     TSLNGAQRWLGVGGLTIQPAELAKFATIIITAKLIELKYDKIKSLTKGVIPLLIIPSIF
                     FALIILQPNLSTAGTVILVTFVMIFVAGMDMKIVYAMFGAGVGLFAVMVLAAPYRLARV
                     TSFIDPFKDPLGAGYQVIQGLYALGSGGLFGLGLGKSRQKYFYIPEPQNDFIFAIIGEE
                     LGLVGCAIVIMLFVFLVYRCIRIAIKCPDVFSCMLVVGIGGQIGIQAALNIAVATSSMP
                     VTGVALPFISYGGTSLTIFMAAVGIVLNVSKHVKMN"
     gene            1635..2843
                     /gene="murG"
                     /locus_tag="FY209_RS00340"
     CDS             1635..2843
                     /EC_number="2.4.1.227"
                     /GO_function="GO:0050511 -
                     undecaprenyldiphospho-muramoylpentapeptide
                     beta-N-acetylglucosaminyltransferase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="murG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_transf_28"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_tran_28_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018589854.1"
                     /locus_tag="FY209_RS00340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="undecaprenyldiphospho-muramoylpentapeptide
                     beta-N-acetylglucosaminyltransferase"
                     /protein_id="WP_021429984.1"
                     /sec_met_domain="Glyco_transf_28 (E-value: 3.7e-36,
                     bitscore: 121.2, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Glyco_tran_28_C (E-value: 1.4e-29,
                     bitscore: 100.1, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVLLSGGGTGGHVYPAIAIANKIKEENPDAEIVFVGTEKGIESE
                     IVPKYGYELRTVTVQGFKRKIDFDNVKRVFKLFKGLEQSRRIVKKFKPDVVIGTGGYVS
                     GPVLFNASMGKVPAIIHEQNSFPGVTNKILAKMVTKVLTSFEDSHVRFPEETRNKLVLT
                     GNPVRKEILISKKSNSRRKLGIQEDKKMVLCYGGSGGSRKINDSMKVVIRNLVNEDVAF
                     IYATGKNFYDGFMSDISDLQLKPYQKVVPYLEDMASALAACDIVIGSAGAISLAEITAL
                     GKPSIIIPKAYTAENHQEYNAKSIESKGAGIAILEKNLTAETLNDTVFKLLGDRDLLID
                     MSNASKEIGKPEAIDIIYKEVMEVYNRNNKKPKKEAKVESKDEKISENEVKEVKTIGIK
                     NKK"
     gene            2928..4181
                     /gene="murA"
                     /locus_tag="FY209_RS00345"
     CDS             2928..4181
                     /EC_number="2.5.1.7"
                     /GO_function="GO:0008760 - UDP-N-acetylglucosamine
                     1-carboxyvinyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="murA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018589853.1"
                     /locus_tag="FY209_RS00345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="UDP-N-acetylglucosamine
                     1-carboxyvinyltransferase"
                     /protein_id="WP_148549745.1"
                     /transl_table=11
                     /translation="MSKYIISGGNKVEGRLDIRGAKNSVLPIMAASILNESENIIKNIP
                     DISDVHVMIDILKSIGCKVEYNEYTLYIDSKNVNVNSVKEEYMKKLRSSIIVMGAMIGR
                     FNNISISYPGGCSIGSRPIDLHLYALDKLGVKITEDRGYIYCNREYLVGNTINLTFPSV
                     GATENAMLAAVKAKGITIINNAAREPEIEDLQNFLNLMGAKVSGAGTSCIQIEGVDKLH
                     SVEHTIIPDRIAIGTYMIASAITGGYLQVDRVISSHMNPIVSRLEELGCNIEYKGTGLE
                     LKAPSKILPIDIIKTSPHPGFPTDMQSQLMTLLCLSKGTSIFHESIFENRFMHCGELSK
                     MGANIIKITENICMVKGVNKLVGAKVEASDLRGGAALILAGLAAEGITEVSNISHVERG
                     YEHIEKTLKSLGANIKKI"
     gene            4326..5060
                     /locus_tag="FY209_RS00350"
     CDS             4326..5060
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020067.4"
                     /locus_tag="FY209_RS00350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FtsQ-type POTRA domain-containing protein"
                     /protein_id="WP_148549746.1"
                     /transl_table=11
                     /translation="MKKNKCKLNKRGKFAIYAFILLVILFIYICISSSIFELKQINVDG
                     NSKITKSDIIKIGDIETGKNIFKYNLNDLEKKLLVNPYIKYVKVSRKFPDKLVITIKEN
                     SEYAIIKEGASYIYIGENGLVLSEQKDIKNKNIPLVSGIEIKNKKLNTKIKINSDKSND
                     IILAIDTLKKNNMSRKVESIKINKNKMYMKTDDNTNIVLKIDEDIEYNIDRLKAILVDL
                     KSNNKKGGNIDLTSKEQAIYSP"
     gene            5393..5524
                     /locus_tag="FY209_RS18360"
     CDS             5393..5524
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018632.4"
                     /locus_tag="FY209_RS18360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF1290 domain-containing protein"
                     /protein_id="WP_224170857.1"
                     /transl_table=11
                     /translation="MGYIIGVPMYYVDILVFGTRLFNNLSIIRRQIVSNLCNKKRGK"
     gene            5629..6810
                     /gene="ftsZ"
                     /locus_tag="FY209_RS00360"
     CDS             5629..6810
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_process="GO:0000910 - cytokinesis [Evidence IEA]"
                     /codon_start=1
                     /gene="ftsZ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906025.1"
                     /locus_tag="FY209_RS00360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cell division protein FtsZ"
                     /protein_id="WP_148549747.1"
                     /transl_table=11
                     /translation="MLNFDVEMDNFAKIKVIGVGGGGNNAVNRMVEAQLKGVEFIAVNT
                     DKQALYTSKAEHKIQVGEKLTRGLGAGANPEVGKKSAEESKDEILKVLEGADMVFVTAG
                     MGGGTGTGAAPVVAQLAKEMGILTVGVVTKPFAFEGKVRMKNAEQGIKELKTKVDTLIT
                     IPNDRLLQIVQKNTSMLEAFSIADDVLKQGIESISDLIAAPGLINLDFADVQSIMKEKG
                     LAHMGMGRAQGENRAIEAARQAIQSPLLETSIKGAKGVLLNITGGANLGLFEINEASTL
                     VQESCDSEANIIFGATIKEDLKDDLVITVIATGFEDGQDMDLDLINRNNAMNQGQHQNF
                     QQNSLNHNPAREPQRPVMPEQKQEDETVVKQNTSSTYIESDDMEIPTFLRRRR"
     gene            6945..7781
                     /locus_tag="FY209_RS00365"
     CDS             6945..7781
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015384.4"
                     /locus_tag="FY209_RS00365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sigma-E processing peptidase SpoIIGA"
                     /protein_id="WP_021430027.1"
                     /transl_table=11
                     /translation="MYVEYYAIENLLVNYIIISCTAIISKNNSSMKKKWTGATIGMIYS
                     ILYLFDNFNLFFSIPMKVLLILIVTKIAFNNESLKGYLRTLTIFYFVNIFIAGSSFFII
                     YCTGLTHLTISFIILITYISGVVLKYIYNDIKELKHIASMKKDMTVCIDEKEVELKALI
                     DTGNLLKDPISKSEVVIISANKLYGILPEEFQKLDLKNINISSIDNVIDKVDKNISYRI
                     RMIPVKQINDSNLVIGIKSDYIKVDGQKIPNVILGLSNFNEDGYNAILNPQLLMSI"
     gene            7802..8533
                     /gene="sigE"
                     /locus_tag="FY209_RS00370"
     CDS             7802..8533
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene="sigE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018589849.1"
                     /locus_tag="FY209_RS00370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RNA polymerase sporulation sigma factor SigE"
                     /protein_id="WP_035115449.1"
                     /transl_table=11
                     /translation="MKNFIKLKSKCIGYFYKILKRLGLLNPKGLYYLGGVNILPPPLST
                     EEEQELLKNLEHDESIKSILIERNLRLVVYISRKFENTGIDVEDLISIGTIGLIKAVNT
                     FKLNKNIKLATYASRCIENEILMYLRKNNKKKTEVSFDEPLNVDLDGNELLLSDILGTE
                     NDEIYKLIEEEIDKDLLVMALDRLSDREKQIMELRFGLASKGNERTQKEVATMLGISQS
                     YISRLEKKIISRLKKEMKKFV"
     gene            8624..9397
                     /gene="sigG"
                     /locus_tag="FY209_RS00375"
     CDS             8624..9397
                     /codon_start=1
                     /gene="sigG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416101.1"
                     /locus_tag="FY209_RS00375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RNA polymerase sporulation sigma factor SigG"
                     /protein_id="WP_021430119.1"
                     /transl_table=11
                     /translation="MQINKVEICGVNTSELPVLKNNQMTELLIKIKNGDEVARQEFVRG
                     NLRLVLSVIQKFNNRGENIDDLFQIGCIGLIKAIDNFDLSQNVRFSTYAVPMIIGEIRR
                     YLRDNNPIRVSRSLKDIAYKALQVRERLVRSNSKEPTVSEIAKELELDVEDVVMALDAI
                     QDPISLFDPVYQDNGDAIFVMDQVQDKKDTDENWLQEIALKEAIKKLNGRERLVLDLRF
                     YKGRTQIEVADEIGISQAQVSRIEKNALKNMRKYI"
     gene            9526..9990
                     /locus_tag="FY209_RS00380"
     CDS             9526..9990
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FY209_RS00380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_021430048.1"
                     /transl_table=11
                     /translation="MLNSSLSYVIIRSFPESIFLILSGYILFNLNINFKNIIKNSLIFL
                     VILTCIRMLPISFGIHTILSMFVIGMIFYKFENQQIIPTIINVSKIYICIAISEGIYMT
                     IADKILKIPTQTLTNNTSINSAILSLPSLLIFILLIIGLNLITKKISENI"
     gene            10001..10642
                     /locus_tag="FY209_RS00385"
     CDS             10001..10642
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016526.4"
                     /locus_tag="FY209_RS00385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="accessory gene regulator B family protein"
                     /protein_id="WP_148549748.1"
                     /sec_met_domain="AgrB (E-value: 2.9e-33, bitscore: 111.7,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAIIEKVSYTISNKIGEKANKSNEEIQVMNYGLFIWIHTILAYIA
                     TILVGIIIGKTIEVLLISIVASSLKKFSGGVHATSPNRCLIIGIITTLIFTYIYVFLNK
                     YCGYNFIYAFSIVSIVSCYYIFYKKAPVGTKNKPLKKEETRNRLRKKLFNRLNVFIAII
                     ILLLIVRLTKISNYDIAMFVYCIELGIILQTIAITKLGETIILKLDCFLK"
     gene            10666..10785
                     /locus_tag="FY209_RS00390"
     CDS             10666..10785
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR04223.1"
                     /locus_tag="FY209_RS00390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cyclic lactone autoinducer peptide"
                     /protein_id="WP_021430072.1"
                     /sec_met_domain="TIGR04223 (E-value: 1.9e-07, bitscore:
                     28.0, seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNFLANLFSDFAVNLGNSASTMCVMVFFEPEMPKSLREE"
     gene            10853..12535
                     /locus_tag="FY209_RS00395"
     CDS             10853..12535
                     /EC_number="2.7.7.65"
                     /GO_function="GO:0009975 - cyclase activity [Evidence IEA]"
                     /GO_process="GO:0009966 - regulation of signal transduction
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025: diguanylate cyclase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR00254.1"
                     /locus_tag="FY209_RS00395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="diguanylate cyclase"
                     /protein_id="WP_148549749.1"
                     /transl_table=11
                     /translation="MNEFENIRNKKVFEILAIIKVIYMLLGMVAMISSYTTIESYNYML
                     FYIYIVAIIILLIVYFIWLSKRQYKFIDNPAKSRDNIETILLMLICTVIIMSTGKEESP
                     YKFLYIFIIIIAAIQFGRNYAMIVSIICSILVCGVDVLSIQFGAHLQEPAKELITNYFQ
                     IDIVIVSAFFVTSWILGMYVNIEKEHSKELQNLANVDELTGLYNHRYFQESLETLMECA
                     DSENTSISMLFMDIDYFKNYNDINGHQAGDVVLKDVGQILKESVREHDIVARYGGEEFA
                     VILPNTVEEDAIIVGERIRINIENTYFYGQENQPNKNMTISIGVSSYPLRASNKHQFIN
                     TADDALYRAKSLNKNRVEVYYSVLEEISDHIYIDEETANSLKRLINMINKKDRYTYGHT
                     ERVVIYLGWFSNYLNLNEKDKLRLKLAAYLHDIGKIEIPEEVLNKKGSLTDLEYDMLKK
                     HPELGVDLIKHVKAFEELLPAIKHHHERYDGRGYPGNLKGKEIPYLARIISIADSFDAM
                     TSHRPYNNRKGHEEAIKELRKCSGSQFDPELVEKFISMIELKK"
     gene            12609..12872
                     /locus_tag="FY209_RS00400"
     CDS             12609..12872
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416105.1"
                     /locus_tag="FY209_RS00400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YlmC/YmxH family sporulation protein"
                     /protein_id="WP_021430001.1"
                     /transl_table=11
                     /translation="MIRISDIMDKEVINVKNGKRMGFITDIEMDTNEGKILSFTIEGDG
                     GMNFFSRNYDGQVVFWNDIIKIGCDTIIVNQGQDHSLDEFNI"
     gene            12902..13357
                     /gene="nrdR"
                     /locus_tag="FY209_RS00405"
     CDS             12902..13357
                     /GO_function="GO:0140110 - transcription regulator activity
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="nrdR"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007789778.1"
                     /locus_tag="FY209_RS00405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transcriptional regulator NrdR"
                     /protein_id="WP_021430012.1"
                     /transl_table=11
                     /translation="MLCPYCNYKESKVIDSRHTDGQSIRRRRECESCKKRFTTYEKIEL
                     TPIMVIKKDNSREYFDRNKIKNGILKSSEKRPVSIEQVEEIIHYIENEINKAYLSEIES
                     KKIGEMVMDKLKDVDEVAYVRFASVYRQFKDINTFVKELKNILTEKR"
     gene            13364..14074
                     /gene="pgeF"
                     /locus_tag="FY209_RS00410"
     CDS             13364..14074
                     /codon_start=1
                     /gene="pgeF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018589845.1"
                     /locus_tag="FY209_RS00410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptidoglycan editing factor PgeF"
                     /protein_id="WP_021433876.1"
                     /transl_table=11
                     /translation="MKNYIRFEEFDKKCDFVNLAFSNINIDMASKSDKENLCKELNMNF
                     ENLTNNKQTHSDIVNIIKKEDIGKIKEGDALVTNLKKTPLLVFVADCVPVAIVDPKKEA
                     VALCHAGWRGTYSKITQKSIENMEKLYGTNPEDLVCVLGPSIGPCCYEVSKDLIEKFNT
                     IITNRDEKFYIIKESKYYLDLWKVNELILTSCGVKKENIVNLNICTSCNSDKFHSYRKH
                     NQTTKRLGMILEVK"
     gene            14092..14784
                     /locus_tag="FY209_RS00415"
     CDS             14092..14784
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416112.1"
                     /locus_tag="FY209_RS00415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_021433875.1"
                     /transl_table=11
                     /translation="MKTKVLVIDDEKHIVELLKFNLETMDYEVHYSYDGFDGFIKAKEI
                     MPDLILLDWMLPNISGIDLLKKIRSDKDLKNIPVIMLTAKNIENDKVEGLDSGADDYIT
                     KPFSVKELLARSNSVLRRYNVNNDNSDKTVLSIGNLKVDLQKHEVIKGTEKIDLTLKEF
                     ELLRLLLENKGKVLSRNYLLDKIWGYEYYGETRTVDVHIRYLRKKIEGTSEEEKYIETI
                     RGIGYKID"
     gene            14798..16084
                     /locus_tag="FY209_RS00420"
     CDS             14798..16084
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416114.1"
                     /locus_tag="FY209_RS00420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_085282445.1"
                     /transl_table=11
                     /translation="MDNISIYFLIVLISIIVSIISIRYAINLRNYLQEFIAVSKKISNK
                     EFHAKINISAKGELGQLVDNFNDMIDTIDITIQEVQYKNLQLKSIVKSISHGILAIDIN
                     GNVLLINEEAKKIIKSDGIEIIEGKNIHHVIKDYKILNEIAKFIGSKKTEMKEITNDED
                     IVYNIKLDPIYLQSSNNVIIGSIINIENITERVKLENMRSDFVANVTHELKTPLTSISG
                     FVETLRINENIDKNMRDRFLGIIETESDRLKRLIDDILLLSFIENKDTITSENVEVLNV
                     FKEVYELTINSAKIKNIELKYKFDDEKIFINSNRDYIKQIFLNLIDNAIKYTPDGGFVE
                     TSVYESNEEVFIKVSDNGIGISKEDKDRVFERFYRVDKARSRDVGGTGLGLAIVKHIVK
                     SLNGTICVKSELNIGTEFTVTIPKKNFLN"
     gene            16145..17077
                     /locus_tag="FY209_RS00425"
     CDS             16145..17077
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025411.4"
                     /locus_tag="FY209_RS00425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YIEGIA domain-containing protein"
                     /protein_id="WP_035115428.1"
                     /transl_table=11
                     /translation="MDDATLFRRAFGVALVLGVLSRLIVLRIVNKQQPTQPQDYIEQLI
                     LSFIAAALGAIAFPALLDKEFAALTFLAVGIQQFQEVASEEEITLSNIDDSELIRKGIT
                     YIHDVSKNYEVRNYLSIFSSLAASIAFITIFNTFKANFIICTISSIVATGVVGYIFKKI
                     LANKSLEDIVDVEVVPIEFDGALLKVGGVVLTNIGLETSKQRYLEKGIGLKVIPKDMVS
                     AGIIGDPAQQQAMLHNVYLHMGIDRDVDEPEFIPIARTNPKDNSVNFGYIPLVRDVDLT
                     VEAIKSAPILDSSKGNNNAYRKKNKNKQN"
     gene            17089..18015
                     /locus_tag="FY209_RS00430"
     CDS             17089..18015
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007287876.1"
                     /locus_tag="FY209_RS00430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YIEGIA domain-containing protein"
                     /protein_id="WP_148549750.1"
                     /transl_table=11
                     /translation="MKSIFIIGIVIGIISRVITLKTDRKQYPTEPNMLVSQLVLAIIGS
                     ALGAMLVPALIQKSYTSITFLSLAASQFRQVRHSKRKSLTDMEDALLVKRGAGFIEEIA
                     LTYEVRSYTCILTALTTSAVYHLSKTELYVGEGGSIFLGAAAGLALALIFKKLFVRESI
                     GAIAEVIPAKISFDGALLKVNDVVISNIGLESSKQRYLDYGLAVEIIPKDGNYINSGII
                     LSPGQRQTIANIAYSRLGIMRTPDEPDFVPLLRRNPKNESLVMPYIPIEKDINQLIAAV
                     KSTPIIESSRGNNWALKRFNIKQQKGV"
     gene            18019..18210
                     /locus_tag="FY209_RS00435"
     CDS             18019..18210
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012063979.1"
                     /locus_tag="FY209_RS00435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_021429980.1"
                     /transl_table=11
                     /translation="MNVGITDVTLAIITTNKEMKSANIPVFYAEDEKELQERGLIISKT
                     MGGMVHDVYHGTLIVVKH"
     gene            18303..19631
                     /locus_tag="FY209_RS00440"
     CDS             18303..19631
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906018.1"
                     /locus_tag="FY209_RS00440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF512 domain-containing protein"
                     /protein_id="WP_148549751.1"
                     /transl_table=11
                     /translation="MEVNVKNTNNIISKVYKDSIAWELGIEVGDLLISINDQPIHDIIE
                     YRFLLSDEYLEVEIKKKNNEIYVYEIEKDYDEDLGIEFTNPIIDKAKSCRNKCVFCFID
                     QLPKGMRETLYFKDDDSRLSFLQGNFVTLTNMSEEDIDNIIRYRISPINISVHTTNPEL
                     RQKMIKNKFAGRLYEIMQRLADAQIQMNCQIVLCPGYNDKEELERTVSDLTKLYPYVNS
                     AAAVPVGITKHRDHLPNLEIFNEQTARETIELVHELQEKYLVELGTRFIFLSDEFYIMA
                     NKKLLDYDDYEGFIQFENGVGMISKLEREIHDYLQTISDEKINSKKKISIATGHSAYEF
                     IKNMASCIMNKCTGVEIEVYKIVNNFFGETITVSGLITATDIINQLKDKDLGQTLYIPR
                     SMLKADEEIFLDNITLEELQNTMNIEVVPCLNEGKDFVDKILK"
     misc_feature    complement(19807..19822)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 23.61"
                     /tool="antismash"
     misc_feature    20377..20395
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: medium, score: 24.61"
                     /tool="antismash"
ORIGIN
        1 ataatagaca cattaagaac atttaaaggt gtagagcata gattagagtt tgttacaaat
       61 aaagatggga ttatgtttgt aaatgactct aaaggaacaa acccagattc gactataaaa
      121 gctataaatt catatgaaaa acctatagtt ttaatagctg gaggatatga aaagcaaagt
      181 gactttactg aaatgattaa atatgcaact aaaaatgtaa aggctctagt cctattagga
      241 cagactgcag aaaaaataga aacaactgca aaagaacatg gaattgataa tatatcaaaa
      301 gttgaagata tggaagctgc agtaaaaaaa gcttatgaaa tagctgaatc aggggatgta
      361 gttttattat caccagcttg tgcaagttgg gatatgtatc caaacttcga ggcaagagga
      421 ttagacttca aagagaatat atataaatta tagatatata actgggaatg gaggtaggtc
      481 taattaatgc ctaaagagat agtaaagaaa cgtgttagta gggggataaa aactgatttt
      541 gacaatgtgg tattttatac aaccatgtta ttagtattta tagggattat aatggttttt
      601 agtgctagtt ttatacaatc tacatttaaa ctagatgatt cctatttctt tttaaaaaga
      661 aacataattt atgcgaccat aggatttatt gctatgattt ttacatctag gatagactat
      721 agattttggt acaaaaatgc gaaaatatta ggaatagtag tagttgtgtt acttctatta
      781 gtactttcac ctcttggaac ttccttaaat ggagctcaaa gatggttagg ggttggagga
      841 ttaacaatac aaccagcaga gttagctaaa tttgcaacaa taataataac tgctaaatta
      901 atagaattaa agtacgataa aataaaatct ttaacaaaag gagttatacc acttcttata
      961 atacctagta ttttctttgc attaataata ttacaaccca atttatcaac tgctggaacg
     1021 gtaatattag ttacttttgt aatgatattc gtagcaggaa tggatatgaa aattgtttat
     1081 gctatgtttg gagcaggagt tggattattt gcagtaatgg tgttagcagc tccgtataga
     1141 cttgctcgtg ttacttcatt tatagacccg tttaaagatc ctcttggagc aggatatcaa
     1201 gtcatacaag gactgtatgc acttggatca gggggactat ttggacttgg actaggaaaa
     1261 agtagacaaa agtattttta cataccagaa ccgcaaaatg attttatatt tgctatcata
     1321 ggagaagaac ttgggcttgt aggatgtgca atagtaataa tgctatttgt atttttagtt
     1381 tatagatgta taagaattgc aataaaatgt cctgatgtat tttcatgtat gcttgttgta
     1441 ggtatcggtg ggcaaatagg tattcaggca gctttaaata tagctgttgc aacatcatca
     1501 atgcctgtta caggagtcgc cttaccattt ataagttatg gaggaacctc ccttacgata
     1561 tttatggcag cagtagggat tgtgcttaat gtctctaagc atgtaaaaat gaattagaca
     1621 ggagatgaaa gttaatgaaa gttttattat ctggtggagg aacaggaggg catgtatacc
     1681 ctgccatagc catagcaaat aagataaaag aagagaaccc agatgctgaa atagtatttg
     1741 taggaacaga aaaaggaata gaatctgaaa tagttcctaa atatggttat gaactaagaa
     1801 ctgttacagt acaagggttt aaaagaaaaa tagattttga taatgttaaa agagtattta
     1861 aattatttaa aggattagaa cagtcaagaa ggattgttaa gaaatttaag ccagatgttg
     1921 ttatagggac aggaggatac gttagtggac cagtactatt caatgcatct atgggtaaag
     1981 ttccagctat aattcatgag caaaactctt tccctggagt tactaataaa attttagcta
     2041 aaatggtaac taaagtttta actagctttg aggattctca tgtgagattc cctgaagaaa
     2101 ctagaaataa attagtactt acaggaaatc cggttagaaa agagattctt atatctaaaa
     2161 aaagtaattc aagaagaaag ttaggaatac aagaagataa aaaaatggtt ttatgctacg
     2221 gaggtagtgg aggatcaaga aaaatcaatg attctatgaa ggtagtaata agaaatcttg
     2281 ttaatgaaga tgtagcgttt atatatgcta caggtaagaa cttctatgat ggttttatga
     2341 gtgatataag tgacttacag ttaaaaccat atcaaaaggt agtaccatat ttagaagata
     2401 tggcaagtgc attagctgct tgtgatatag ttataggaag tgcaggggct atatctttag
     2461 ctgagataac agctcttggt aaaccatcta taataatacc taaagcctat acagcagaaa
     2521 atcatcagga atacaatgcg aaaagtatag aaagcaaagg tgctggaata gctattttag
     2581 aaaaaaatct tacagctgaa actttaaatg atacagtatt taaattatta ggagacagag
     2641 atcttttaat agacatgtca aatgcaagta aagaaatagg aaaaccagaa gcgatagaca
     2701 taatatataa agaagttatg gaagtttata atagaaacaa taaaaagccg aaaaaagagg
     2761 ctaaagttga aagtaaagat gaaaaaataa gtgaaaatga agtaaaagaa gttaagacaa
     2821 tcggtataaa aaataaaaag taacatattt cccctctagt acatagtatt aaaaatataa
     2881 gaagttatat tttaggctaa aaatacttgc tactaggggg gatacttttg tcaaagtata
     2941 taattagtgg aggcaacaaa gtagaaggta ggctggatat aagaggagca aaaaactctg
     3001 tattgcctat aatggctgcg tctatactaa atgaatctga aaatataata aaaaacattc
     3061 cggatatatc agatgtacat gtaatgattg atatattgaa aagcatagga tgtaaagttg
     3121 aatacaatga gtatacttta tatatagata gcaaaaatgt taatgtaaac agtgttaaag
     3181 aagagtatat gaaaaaatta agatcatcca ttatagtaat gggggcaatg ataggaagat
     3241 ttaacaatat aagcataagc tatccaggag gatgttctat aggttctaga ccgatagatc
     3301 ttcatttata tgctttggat aaactaggtg taaaaataac tgaagacaga ggatatatat
     3361 attgtaatag agagtatttg gtaggaaata ctataaactt aacatttcca agtgtaggtg
     3421 ctacagaaaa tgcgatgttg gcagccgtaa aagcaaaggg aataacaata ataaataatg
     3481 ctgcaagaga acctgagata gaagacttgc aaaatttttt gaatttaatg ggagcaaaag
     3541 taagtggagc aggaactagt tgtattcaaa ttgagggtgt agataaatta cattctgtcg
     3601 aacatacaat aattcctgat aggattgcaa tagggactta tatgattgct agtgctataa
     3661 ctggagggta tttacaagtt gatagagtta taagtagcca tatgaaccct atagttagca
     3721 gattagaaga attgggatgt aatattgaat ataaaggaac tggattagaa cttaaagctc
     3781 caagtaaaat tttacctata gatataataa aaacatcgcc tcatcctgga tttcctactg
     3841 acatgcaatc tcagcttatg actttattat gtttaagtaa aggcactagt attttccatg
     3901 aatcaatatt tgaaaatcga tttatgcatt gcggagaact ttctaaaatg ggagcgaaca
     3961 taataaaaat aactgaaaat atttgcatgg tgaagggtgt aaataaactt gttggggcta
     4021 aagtggaagc ttcggattta agaggaggag cagccttgat attggcaggt ctagctgcag
     4081 aaggaataac tgaagttagc aatattagcc atgtagaacg aggttatgag catattgaaa
     4141 aaacattgaa aagtctaggt gcaaatataa aaaaaattta gtataaaaaa agaaatcgaa
     4201 ttagttttat gtactattac gatttctttt tttgaaattt taaaatatta aataatcaaa
     4261 taacaaagga taagctattg ttatgtagta ttttataata tataaaatac taaaggtggg
     4321 ttattatgaa aaaaaataaa tgcaagttaa ataagagagg taaatttgct atatatgctt
     4381 ttattttgct agttatatta tttatttata tatgtataag tagtagtatt tttgaactta
     4441 aacaaatcaa tgtggatgga aatagtaaaa taactaaaag cgacataatt aaaataggag
     4501 atattgaaac tggcaaaaat atttttaaat ataatttaaa tgatttagaa aaaaaattat
     4561 tggtaaaccc atacataaaa tatgttaaag ttagtaggaa gtttcccgat aagttagtaa
     4621 taacaattaa agaaaatagt gaatatgcaa taataaaaga aggagcaagt tatatttata
     4681 taggtgaaaa tggattggtt ttatcagaac aaaaagatat aaagaacaag aatatcccct
     4741 tagtaagtgg tattgaaata aaaaataaaa aattaaacac aaagattaaa atcaattcag
     4801 ataaatcaaa tgacataatt ttagctatag atacattgaa aaagaataat atgtcaagga
     4861 aagttgaaag tataaaaata aataaaaata aaatgtacat gaaaacagat gataacacaa
     4921 atattgtttt gaaaatagat gaagatatag agtataatat cgatcgatta aaggctatac
     4981 tagttgattt aaaatctaac aataaaaaag gtggtaatat agacttgact tccaaagaac
     5041 aagctatata ctctccatga tgttaaactt tattataatt tcaaaatgct tatatttact
     5101 aaaatataag caacaaattg ttttgaaaat taatttttgt ttattaaatt ttacaaatga
     5161 ataacgaaat ttatgtgtat ttacaaattc ttgtaaaaaa catgaataaa aaacttgaat
     5221 aatggaggta tttcaaagta aaatatagaa ggtgaatatt tataatatag gtaattaatg
     5281 gtagttcgct tattataata actgggtatt atatttaaat gacattatac aatagagtac
     5341 tctggatata agtaaattaa aaattaaatt aggctttaaa aaatttactt acataggata
     5401 tataatagga gttcctatgt attatgtaga tatattggta tttgggacaa ggttatttaa
     5461 taatttatca attataagaa gacagattgt atctaattta tgcaataaaa aaagaggaaa
     5521 atgaactttt ttgtggaata agttagttaa atattaacaa aatgctaata taaaatgata
     5581 taattaatac atagatttac tttgaatatt aaataaggag gtttgtagat gctaaacttt
     5641 gacgtagaaa tggataactt tgcaaaaatc aaagtaatag gcgtaggtgg cggtggtaac
     5701 aacgctgtca acagaatggt tgaagcacaa ctaaaaggtg ttgaatttat agctgtaaat
     5761 actgataaac aagctttata tacatctaaa gctgagcata aaattcaagt tggagagaaa
     5821 cttactagag gtttaggagc aggagcaaac ccagaagttg ggaaaaagtc tgcagaagaa
     5881 agtaaggatg aaatactcaa agttcttgaa ggtgcggata tggtatttgt aactgcagga
     5941 atgggcggag gaacaggaac aggagctgca cctgtagttg ctcaattagc aaaagagatg
     6001 ggtatactta cagtaggtgt agtaacaaaa ccttttgctt ttgaaggtaa agtaagaatg
     6061 aaaaacgcag aacaaggtat aaaagagtta aagacaaaag ttgatacttt aataactata
     6121 cctaatgata gattgttaca aatagttcaa aagaatacat ctatgttaga agcattttca
     6181 atagcagatg atgtattaaa acaaggtata gaatctatat cagacttaat tgcagcacca
     6241 gggttaataa acctagactt tgctgacgtt caatctataa tgaaggaaaa aggcctagca
     6301 catatgggta tgggaagagc tcaaggcgaa aatagagcta tagaagcagc aagacaagct
     6361 atacaatcac cattactaga aacgtctata aaaggagcta agggtgtttt acttaatata
     6421 acaggtggag caaacttagg actatttgaa ataaatgaag cttctacatt agttcaagaa
     6481 tcttgtgatt ctgaagctaa tataatattt ggagctacaa taaaagaaga tttaaaagat
     6541 gatcttgtta taactgttat agctacaggg tttgaagatg gacaagatat ggatttagat
     6601 ttaataaata gaaacaacgc aatgaatcaa ggacaacatc aaaactttca acaaaacagt
     6661 ttaaatcata atccggcacg agagcctcaa agaccagtaa tgccagaaca aaaacaagaa
     6721 gatgaaactg ttgttaaaca aaatacaagt tcaacataca tagaaagtga tgatatggag
     6781 attccaacat tcctaagaag aagaagatag tactatcttc tttttttttg cgtttttttg
     6841 ttttatttaa gaataaatta aatttggttc gactatcaat tatgacataa aactcattaa
     6901 acctaaacta taatataggt aaatgtttca agggggggat ggaggtgtac gtagaatatt
     6961 atgcaattga aaacttatta gtaaattata taataataag ttgcactgct ataatttcaa
     7021 aaaataatag ttctatgaag aaaaaatgga caggtgctac aattggaatg atatattcaa
     7081 ttttgtattt atttgataat tttaatttgt ttttttcaat tcctatgaaa gtattattaa
     7141 ttttaattgt aaccaaaata gcatttaata atgaatcgtt aaagggatat ttaaggactt
     7201 tgaccatatt ttattttgtt aatattttta ttgctggaag ttcgtttttt attatatatt
     7261 gtacaggcct cacacattta actatatctt ttataatctt aattacatat ataagtgggg
     7321 tagttcttaa atatatttat aatgacataa aagaattaaa gcatatagca agtatgaaaa
     7381 aggatatgac ggtatgtata gatgaaaaag aggtggaact taaagcttta atagatacag
     7441 ggaacttatt gaaagatccg ataagtaaaa gtgaagttgt tattataagt gctaataaat
     7501 tatatggaat tttacctgaa gaattccaaa aactagatct taaaaatata aatataagtt
     7561 caattgataa tgttatagac aaagttgata aaaatatatc ttataggatt agaatgatac
     7621 ctgtaaagca gataaatgat agcaacttgg taataggcat aaaatcagat tacataaaag
     7681 ttgatggaca aaaaatacct aatgtaatat tagggctttc caattttaat gaagatggtt
     7741 ataacgctat attaaatcca caactattaa tgagtatata aaatttaagg gggatagttt
     7801 tatgaaaaat tttataaaat taaagtcaaa gtgtataggt tatttttata aaatattaaa
     7861 aagattaggt cttttaaatc caaagggtct atattacttg ggaggcgtaa atatattgcc
     7921 tccaccgctt tctactgagg aagagcaaga gcttttaaaa aacttagaac atgatgaaag
     7981 tataaaatct atcttaattg aaagaaattt aagattggta gtatatatat ctaggaaatt
     8041 tgaaaataca gggattgatg tggaagatct tatatcaata gggacaatag gtttaataaa
     8101 agctgtgaat acatttaagt taaataaaaa tataaagcta gctacttatg catctagatg
     8161 tatagaaaat gaaatactta tgtatttaag aaaaaacaat aaaaagaaaa cagaggtatc
     8221 atttgatgag cctcttaatg tcgacttaga tgggaatgaa cttttattat ctgatatatt
     8281 aggaacagaa aatgatgaaa tatacaagtt aatagaagag gagatagata aagatctttt
     8341 agttatggct cttgatagac tttcagatag agaaaaacaa attatggagt taagatttgg
     8401 gctagctagc aaaggaaatg aaagaactca aaaggaagtt gctacgatgt taggcatatc
     8461 acaatcgtac atatctagat tggagaaaaa gataatatct agactaaaaa aagagatgaa
     8521 aaaatttgtt tagagaataa ataattactc ttaaacagta taaaaatata ctagatgtaa
     8581 ataattgtat aagaaatact ttttaagaga ggactgagtt gtaatgcaaa taaataaagt
     8641 tgaaatctgt ggagtaaata cctctgagtt accagttctt aaaaataatc aaatgacaga
     8701 actccttata aaaattaaaa atggagatga agtagctaga caagaatttg taagaggaaa
     8761 tctaagattg gttctgagtg taattcaaaa gtttaataac agaggggaaa atattgacga
     8821 tttatttcaa ataggttgta taggacttat aaaggcaatt gataattttg acttaagtca
     8881 aaatgtaaga ttttcaactt atgcagtccc tatgattata ggagagataa ggaggtatct
     8941 aagagataat aatcctataa gggtgagtag gtccttaaaa gacattgcat ataaagctct
     9001 tcaagtgaga gagaggctag taaggtctaa ttctaaggaa ccaactgttt cggagatagc
     9061 taaagagctt gagctagatg ttgaagatgt agtaatggct ttagatgcta ttcaagatcc
     9121 tatatcatta tttgatccgg tatatcagga caatggagat gctatatttg taatggacca
     9181 agttcaagat aaaaaagata cggatgaaaa ttggttacaa gaaatagctc ttaaagaagc
     9241 tataaaaaaa ttaaatggaa gagaacgatt ggttttagat ttaagatttt ataaagggag
     9301 aactcagatt gaagtagctg atgagattgg tatttctcaa gcgcaagttt ctaggataga
     9361 gaaaaatgct ttaaaaaaca tgagaaaata tatataaaaa atatgcaaaa gtagtactac
     9421 ttttgcatat ttttttgatg tactcataat tgcatattaa ttgtaaaaaa atgtaaaata
     9481 tggtataatt cgtagtggat aatattagtg aagagggaga attgaatgtt aaattcatca
     9541 ttatcatatg taataattag aagttttcca gaaagcattt ttttaatttt atctggatac
     9601 attttattta acttaaatat taattttaaa aatattatta aaaattcttt gattttttta
     9661 gtaatattaa catgtattag gatgttacct ataagttttg gaatacatac tattttaagt
     9721 atgtttgtga taggaatgat tttttataag tttgaaaatc aacagattat ccccactata
     9781 ataaatgtat caaagatata catatgcata gcaattagtg aaggaattta tatgacgatt
     9841 gcagataaaa tattaaaaat acctacacaa acattgacaa ataacacgag tattaacagc
     9901 gcgatattat cacttccatc attactaata tttattttat taattattgg attaaattta
     9961 ataactaaaa aaataagcga aaatatatag gggtaaactt atggctatta tagaaaaggt
    10021 ttcatatact atttcaaata aaataggtga aaaggcaaat aagagtaatg aagaaataca
    10081 agttatgaat tacgggttat ttatttggat acacactata ttggcttaca tagctacaat
    10141 tttagtagga ataataatag gaaaaacgat agaagtttta ttaatttcta ttgttgcatc
    10201 tagtttgaaa aagttttcag ggggagttca tgcaacatct cctaatagat gtttgataat
    10261 aggtattata acaacattaa tttttacgta tatttatgtt tttttaaata aatattgtgg
    10321 gtacaatttt atatatgctt tcagtatagt aagtattgta tcatgttatt atatttttta
    10381 taaaaaggct ccagttggaa caaaaaataa gcctttaaag aaggaagaaa caagaaatag
    10441 actaagaaaa aaattattta atagacttaa cgtttttatt gcaattataa tattactttt
    10501 aatagttaga ttaactaaaa tttcaaatta tgacatagct atgtttgtat attgtataga
    10561 attagggatt atattacaaa caatagcaat aactaagcta ggagaaacaa tcatattaaa
    10621 attagattgt tttcttaaat aaaaaatatt taagggggat tagctatgaa ctttttagca
    10681 aatttattct cagattttgc agtgaattta ggaaattctg catctacaat gtgtgtgatg
    10741 gtattctttg aaccagaaat gccaaaatct ttaagagaag agtaatttta aataaaccat
    10801 aaggatatat ccttatggtt tattaattaa aaaggaaatt taggagaaaa gaatgaatga
    10861 gtttgaaaat ataaggaata aaaaagtatt tgaaatatta gcaataataa aagttatata
    10921 catgctttta ggaatggtag ctatgataag ttcttataca acaatagaaa gttataatta
    10981 tatgttattt tacatataca tagttgctat aataatactt ttaatagttt actttatatg
    11041 gttatcaaag agacaatata aatttataga taatccagca aaatctagag acaatataga
    11101 aacaatttta ttaatgctaa tatgtacagt tataataatg tcaacaggta aagaagagag
    11161 tccttataaa tttctatata tttttataat tataatagca gcaatacaat ttggaagaaa
    11221 ctatgctatg attgtttcta taatttgttc tatattagtt tgcggagtgg atgtactatc
    11281 aatacaattt ggagctcatc ttcaagaacc agctaaagag ttaataacaa attattttca
    11341 aattgatata gttatagtaa gtgctttttt tgtaacgtca tggatactag ggatgtacgt
    11401 taatatagaa aaagagcata gtaaagaact tcaaaatcta gctaatgtag atgaacttac
    11461 gggtttatat aatcatagat attttcaaga atcattagaa acactaatgg agtgtgctga
    11521 tagtgaaaat acatcaatct cgatgttgtt tatggatatt gattatttta aaaattacaa
    11581 cgatataaat gggcatcaag caggggatgt tgttttaaaa gatgtaggtc aaattttaaa
    11641 agaaagtgta agagaacatg atattgtagc aagatatgga ggcgaagaat ttgctgtaat
    11701 tcttccgaat actgtggaag aagatgctat aatagttgga gagagaatta gaataaatat
    11761 agaaaataca tatttttatg ggcaagaaaa tcaaccaaat aaaaatatga ctatatctat
    11821 aggagtttca tcatatccgc taagggcaag taataagcat cagtttataa atacggcaga
    11881 tgatgctctt tatagggcta agtcacttaa taaaaatagg gtagaagtat attatagtgt
    11941 tttagaagaa atttcagacc atatatatat agacgaagaa acagccaatt cattaaaaag
    12001 acttataaac atgataaata aaaaagacag atatacatat ggacatacag aaagagtagt
    12061 tatataccta ggttggtttt caaactattt aaatctcaac gaaaaagata aactgcgttt
    12121 aaaactagca gcttatcttc atgatatagg taaaattgaa attccagaag aagtattaaa
    12181 taaaaaagga agtctaactg atttagagta tgatatgtta aaaaaacatc cagaattggg
    12241 cgtggattta ataaagcatg taaaagcatt tgaagaatta ttaccagcta taaaacatca
    12301 ccatgaaaga tacgatggaa gagggtatcc aggcaattta aaaggcaagg aaatcccata
    12361 tttagctaga ataatatcca tagcagatag ttttgatgca atgacatctc atagacctta
    12421 caataataga aaaggtcatg aagaagctat aaaagaactt agaaaatgtt caggaagtca
    12481 gtttgatcca gaattagttg aaaaatttat aagtatgata gaattaaaaa aataatttaa
    12541 aatggccagt atggtcattt ttttttattc ttgtacatat ttatttttaa gaggaggtag
    12601 attataatat gattagaatt tctgatataa tggataaaga agtaataaat gttaaaaatg
    12661 gtaaaagaat gggatttatt acagatatag agatggatac gaatgaagga aaaattttat
    12721 cattcacaat tgaaggtgat ggaggtatga actttttttc aagaaattat gatgggcaag
    12781 ttgttttttg gaatgatata ataaaaatag gatgtgatac aattatagta aaccaaggtc
    12841 aagatcatag tttagatgaa tttaatatat aaaagacata agaaaaaagg agggataggc
    12901 tttgttatgt ccttactgca attataaaga atcaaaggta atagactcaa gacatacaga
    12961 tggtcaatct ataagaagac gaagagagtg tgaatcttgt aagaagagat ttactacata
    13021 cgaaaaaata gaattaactc ctattatggt tataaaaaaa gataatagta gagaatattt
    13081 tgatagaaat aaaataaaaa atggtatatt gaagtcttct gaaaaaaggc ctgtttcaat
    13141 agagcaagtt gaagaaataa tacactacat agaaaatgaa ataaacaagg cttacttatc
    13201 agaaatagaa agtaaaaaga taggtgagat ggtaatggat aaattaaaag atgtagatga
    13261 agtagcgtat gtaagatttg catcagtata tagacaattt aaagatataa atacatttgt
    13321 taaagagctg aaaaatatac taacagaaaa aaggtgattg agtatgaaaa actatataag
    13381 atttgaagaa tttgataaaa agtgtgattt tgtaaactta gcattttcca atataaatat
    13441 tgatatggca tcgaagtctg ataaagaaaa tctttgtaaa gagttaaata tgaatttcga
    13501 aaacttaaca aataataaac aaactcactc agatatagta aacataataa aaaaagaaga
    13561 tatagggaaa ataaaagaag gggatgcttt agttacaaat ttgaaaaaaa ctccactatt
    13621 agtttttgtt gcagattgtg ttcctgtggc tattgtggat cctaaaaagg aagctgtagc
    13681 actttgtcat gcaggatgga gaggtacata ttctaaaata actcaaaaat ctattgaaaa
    13741 tatggaaaag ctgtatggaa caaaccctga agatttggtt tgtgtattag gaccttcaat
    13801 tggaccttgt tgttatgagg tatctaaaga tttaattgaa aaatttaaca caattattac
    13861 aaatagagat gaaaaatttt atataattaa agaaagcaag tactatctag atttatggaa
    13921 agtaaatgaa ttgatattga caagttgtgg tgtgaaaaaa gagaatatag ttaatttaaa
    13981 catatgcact agttgtaaca gtgacaagtt tcattcctat agaaaacaca atcaaacaac
    14041 aaaaaggcta ggtatgatac ttgaagtaaa gtagagaggg gctaacttaa gatgaaaact
    14101 aaagtgttag ttatagatga tgaaaagcat attgtagagc ttttaaaatt taacttagaa
    14161 actatggatt atgaggttca ttattcatac gatggatttg atggatttat aaaagctaaa
    14221 gagataatgc cagacttaat attattggat tggatgcttc ccaatataag tggaatagac
    14281 cttttaaaga aaattagaag tgataaagat ttaaaaaata tacctgtaat aatgctaaca
    14341 gctaaaaata ttgaaaacga caaggtagaa ggattagatt caggtgctga tgattatata
    14401 acaaagccat ttagtgtaaa agagttatta gctagaagta actctgtttt aagaagatat
    14461 aatgtcaata atgacaatag tgataagaca gtgttaagta taggaaattt aaaagtagac
    14521 ttacaaaagc atgaggtaat taaaggcact gaaaagatag atttaacact taaagaattt
    14581 gaacttttaa gacttttact agaaaacaaa ggaaaggttt tatcaagaaa ctatttatta
    14641 gataaaatat ggggatatga atattatgga gaaactagaa ctgtagatgt tcatataaga
    14701 tatttaagaa aaaaaataga aggaactagt gaagaagaaa aatatataga aactattaga
    14761 ggaataggat ataaaataga ttaaggggcg ttttaacatg gataatataa gcatatactt
    14821 tttaattgtt ttaatatcaa ttatagtttc tataatttca ataagatatg ctataaattt
    14881 aagaaattac ttacaagaat ttatagctgt ttcaaaaaaa ataagtaaca aagaattcca
    14941 tgcaaaaata aacatatcag caaaaggtga attagggcaa ctagttgata attttaatga
    15001 tatgattgat acaatagata ttacgattca agaagttcaa tacaaaaatt tacaattaaa
    15061 atctattgta aaaagtatat cacatggtat tttagctatt gatataaatg gaaatgtttt
    15121 attgataaat gaagaagcaa aaaaaataat aaaaagtgat ggaattgaga taatagaagg
    15181 taagaatata catcacgtta taaaagacta taaaatatta aatgaaattg ctaaatttat
    15241 aggatcgaag aaaactgaaa tgaaagaaat taccaacgat gaagacatag tatataatat
    15301 aaagctagac cctatatacc ttcaaagtag caataatgtt atcattggtt ctataataaa
    15361 catagaaaac ataactgaaa gagttaagtt agaaaatatg agaagtgact ttgttgctaa
    15421 tgtaactcat gagttaaaga cacctcttac atctataagt ggatttgtag aaacattaag
    15481 aataaatgaa aatatagata aaaatatgag agatagattc ttaggaataa ttgaaacaga
    15541 atcggacaga ctaaaaaggc ttatagacga tatattatta ctttcattta tagaaaataa
    15601 agacactata acatctgaaa atgtagaggt actaaatgta tttaaagaag tttatgagtt
    15661 aacgattaac tctgccaaga taaaaaatat tgaattaaaa tataaatttg atgatgagaa
    15721 aatttttata aactcgaata gagattatat taaacaaata tttttgaatt taatagataa
    15781 tgctataaaa tatactcctg atggaggttt tgtagaaact agtgtatatg aaagtaatga
    15841 agaagtattt ataaaagttt cagataatgg aattggaata tctaaagaag ataaagacag
    15901 ggtatttgag aggttttata gagttgataa ggctaggagt agagatgtag gtggtaccgg
    15961 gctagggctt gctatagtaa aacatatagt taaatcttta aatggaacta tatgtgtaaa
    16021 aagtgaatta aatataggaa ctgaatttac agttactata ccaaaaaaaa atttccttaa
    16081 ttaaggaaat ttttttttgt ttttgcacac aataaagata gtaaaaataa aaggaggata
    16141 acatatggat gatgctacat tatttaggcg tgcatttggg gtagctttag tacttggcgt
    16201 tttatcaagg cttatagtat taaggatagt aaataagcaa caaccaactc agcctcaaga
    16261 ttatatagaa caacttattt tatcatttat tgcagcagca ttaggagcaa tagcatttcc
    16321 agctttatta gataaagaat ttgcagcact tactttttta gcagtaggga tacaacaatt
    16381 tcaagaagta gcgagtgaag aagaaataac cttatctaat atagatgata gtgagttgat
    16441 tagaaaagga attacttata ttcatgatgt gtctaaaaac tacgaggtta gaaattatct
    16501 gagcattttt tcatcactag ccgcatctat agcatttata acaatattta acacatttaa
    16561 agctaacttt attatttgta ctatatcatc aattgtggca acgggagtag ttggttatat
    16621 atttaaaaaa atactagcaa ataaaagttt agaggatatt gttgatgtag aagttgtacc
    16681 aatagaattt gatggagcat tattaaaagt aggaggggta gttttaacaa atatagggct
    16741 agagacatca aaacaaagat atttagaaaa gggtatagga cttaaagtta tcccaaaaga
    16801 tatggtgtct gctggtataa taggagatcc agctcaacaa caagctatgc tacataacgt
    16861 atatttacat atgggaatag atagagatgt tgatgagcca gaatttatac ctatagccag
    16921 aacaaacccc aaagataact cagttaattt cgggtacatt ccattagtta gagatgttga
    16981 tttaacagta gaagctataa aaagtgcacc tatattagat agttcaaaag gaaataacaa
    17041 cgcatataga aagaaaaata agaacaagca aaattaaggg gtgagtaaat gaaaagtata
    17101 tttataattg gtatagtaat tgggattatt tcaagggtca taacattaaa aacagaccga
    17161 aaacaatatc caacagaacc aaatatgtta gtatcacaac ttgttttagc tattatagga
    17221 tcagctttag gagcgatgtt agtacctgct ttaatacaaa aatcatatac atcaattaca
    17281 tttttatcac ttgcagctag ccaatttaga caagttagac atagtaagag aaagtctttg
    17341 acagatatgg aagatgctct attagtaaaa cgtggagctg ggtttattga agaaattgct
    17401 ttaacatatg aagttagaag ttatacttgc attcttacag ctttaacgac gtcagctgtg
    17461 tatcatttat ctaagacgga gctttatgta ggagaaggag gaagtatatt cctaggggca
    17521 gcagcagggc ttgcattagc gttgatattt aaaaaactat ttgtaagaga aagtatagga
    17581 gctatagctg aggttattcc agcaaaaata tcatttgacg gagcactatt aaaagtaaat
    17641 gatgttgtaa tatccaatat aggattagaa tcttcaaaac aaaggtattt agattatgga
    17701 ctagcagtag aaatcatacc taaagatggg aattacataa atagcggtat aatactaagt
    17761 ccaggacaaa gacagacgat agctaatata gcgtactcaa gactaggaat aatgagaact
    17821 ccagatgaac ctgactttgt tccacttttg agaagaaatc ctaaaaatga aagtttagta
    17881 atgccatata tacctattga gaaagatata aatcagctta tagcagcagt caaaagtaca
    17941 cctataattg agagctctag aggaaacaat tgggcattga agagatttaa tataaaacaa
    18001 caaaaaggag tgtagaacat gaatgtaggt ataactgacg taacattagc tataattact
    18061 acaaataaag aaatgaaatc tgctaatatt cctgtttttt atgcagaaga tgaaaaagaa
    18121 cttcaagaaa gaggcttaat aatatctaaa actatgggag gtatggttca tgatgtatat
    18181 catggaactc taatagtagt gaagcattaa aggtaccttt aaaggtacct ttttattgac
    18241 tattttaaag aaaacgtggt aatataatgt gatgtactta taaaggaaaa gtggtgaaat
    18301 ttatggaagt caatgtaaaa aatacaaata atataatcag caaagtatac aaagatagca
    18361 tcgcttggga actaggaata gaagttggag acttgttaat ttctataaat gatcaaccga
    18421 tacatgatat aatagaatat agattcttgc taagtgatga gtacttagaa gtagaaataa
    18481 aaaagaaaaa caatgaaata tatgtgtatg aaatagagaa agattatgat gaagatttag
    18541 gaattgaatt tacaaatcct ataatagata aagctaaaag ttgtagaaat aaatgtgtat
    18601 tttgctttat agatcaatta ccaaaaggta tgagagaaac actttatttt aaagatgatg
    18661 attcaagatt atcattttta caaggaaact ttgtaacttt aacaaatatg agtgaggaag
    18721 atatagataa tataattaga tatagaataa gtcctattaa tatatctgtt cacactacaa
    18781 atccagagct tagacaaaaa atgattaaaa ataagtttgc tggaaggctt tacgaaataa
    18841 tgcaaagatt agctgatgct cagatacaaa tgaattgtca gattgtttta tgtccaggtt
    18901 acaatgacaa agaagaatta gaaagaactg tatctgattt aacgaaacta tatccgtatg
    18961 taaatagtgc agcagcagtg ccagtaggaa taactaaaca cagagaccat ctaccaaact
    19021 tagaaatatt taatgaacaa actgctagag aaactataga gttagttcat gaattacaag
    19081 aaaaatatct agttgaacta ggaacaagat ttatattcct atcagatgag ttttatataa
    19141 tggcaaataa aaaattatta gattatgatg attatgaagg ctttatacaa ttcgaaaatg
    19201 gagtaggtat gataagtaag ttagaaagag aaattcatga ctatctacaa actatttcgg
    19261 atgaaaagat aaattctaaa aagaaaattt ctatagctac gggacactct gcatatgaat
    19321 ttataaaaaa tatggcgagt tgcataatga ataaatgcac aggagtagag atagaggttt
    19381 acaagatagt aaataacttc ttcggagaaa ctataactgt atctgggctt ataacagcta
    19441 cagatataat aaatcagtta aaggacaagg acttaggtca aactttatat ataccaagaa
    19501 gtatgttaaa agcagatgaa gaaatatttt tagacaatat tacactagaa gaattacaaa
    19561 atactatgaa tattgaagtt gtaccttgct taaatgaagg taaagacttt gttgataaga
    19621 ttttgaaata gagagggagg ttattatgaa cgataataga ccggtagttg cagtagttgg
    19681 aagacctaat gttggtaaat caactttatt taataagtta gcaggaaaaa gaatatcaat
    19741 agttgaagat actccaggag taacaagaga tagaatattt acagaggtag aatggttaaa
    19801 caaatatttt acacttgtag atactggagg tatagagcca aatagtgatg atataatatt
    19861 atctcaaatg agaaatcaag ctatgcttgc tatggatatg gctcacgtta taatgtttgt
    19921 tgttgatggt aaagcaggtc ttacagcagc ggataaagaa gtagcacaaa tgcttagaaa
    19981 aactaagaca cctgtaatat tagtagtaaa caaaatagat agtcaaactc aatttgacaa
    20041 tgtatatgat ttttatgagt taggattagg ggttccattt gcaatatcta gtgcaaatag
    20101 tatgggactt ggagacttac ttgatgaagt tgtagctaac ttcccagaag gattagatac
    20161 agagtatgac gaagatataa taagagttgc tataacaggt aaacctaatg caggaaaatc
    20221 ttctatatta aacaatatgt taggagagga acgagttata gtaagtccta tagctggaac
    20281 aactagagat gctatagaca cttatttaga aaaaggagat aataaattcc ttttaataga
    20341 tacagcagga cttagaagaa aaagtaagat atatgaaaat gtagaaaaat acagtgtaat
    20401 aagagctatg agtgcggtag atagagcgga tgtagttctt attgtaatag atgcagaaca
    20461 aggtgtaaca gagcaagata caaaagtagc aggtattgca catgatgaag gtaaggcttg
    20521 tttatttgta ataaataaat gggacttaat agaaaaaaat gataaaacta tgagtatata
    20581 tacaaaaact ataagagaaa aattcccgtt catggcgtat gcacctatag tatttgtatc
    20641 tgcaaaaaca aaccaaagaa tgaataaaat attagaaaca gtaacttata tagctgaaga
    20701 acatgctaag agagttccaa catcaacatt aaatgatgta ataggtgaag ctgtacttct
    20761 taatcaacct ccttcagata aaggg
//
