GCF_902166815.1 - 4 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_LR607378.1 (Enterococcus faecalis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	lanthipeptide-class-ii	5,772	33,619	Low	staphylococcin C55 α/staphylococcin C55 β	ribosomal:RiPP:Lanthipeptide
Region 2	cyclic-lactone-autoinducer	727,105	747,833
Region 3	NRPS,arylpolyene	1,840,076	1,884,372
Region 4	terpene-precursor	2,093,323	2,114,204

NZ_LR607378.1 - Region 1 - lanthipeptide-class-ii

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Location: 5,772 - 33,619 nt. (total: 27,848 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

FN751_RS00145: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Lyases: cyclase

FN751_RS00130: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

FN751_RS00140: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000520.5	0.78	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000555.3	0.71	ribosomal	staphylococcin C55 α, staphylococcin C55 β	Staphylococcus aureus
BGC0001229.4	0.63	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0002110.3	0.59	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0001391.3	0.55	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000525.5	0.53	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000517.4	0.51	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0002663.2	0.51	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639
BGC0001555.4	0.51	ribosomal	colicin V	Escherichia coli chi7122
BGC0002698.2	0.51	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000520.5	0.78	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000555.3	0.71	ribosomal	staphylococcin C55 α, staphylococcin C55 β	Staphylococcus aureus
BGC0001229.4	0.63	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0002110.3	0.59	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0001391.3	0.55	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000525.5	0.53	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000517.4	0.51	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0002663.2	0.51	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639
BGC0001555.4	0.51	ribosomal	colicin V	Escherichia coli chi7122
BGC0002698.2	0.51	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for FN751_RS00130

FN751_RS00120

Leader:

MRDEENNETLINNEQVAWFEEVADQSFDDDVFGA

Core:

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

Core with dehydrations:

CysDhbDhbNDhbFDhaLDhaDYWGNKGNWCysDhbADhbHECysMGWCysK

antiSMASH-DB 4.0 matches for FN751_RS00120

100.0%

NZ_AP026714.1and 21 others:

NZ_AP026714.1 Lanthipeptides: PO853_RS06515_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptide

Lanthipeptides: PO853_RS06515_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

93.3%

NZ_BLIS01000009.1and 7 others:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04820_lanthipeptideNZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptideNZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptide

Lanthipeptides: GVO03_RS04820_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

CTTNTFSLSDYWGNKGNWCT THECM WCK

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

93.3%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06330_lanthipeptide

Lanthipeptides: IE339_RS06330_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

CTTNTFSLSDYWGNKG WCTATHECM WCK

CTTNTFSLSDYWGNKGGWCTATHECMSWCK

with 105 more sequence matches

Only the first 10 are displayed here.

93.3%

NZ_PCGR01000003.1and 1 other:

NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09620_lanthipeptide

Lanthipeptides: CQS04_RS09620_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

CTTNTFSLSDYWGN GNWCTATHECM WCK

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

86.7%

NZ_FMPI01000012.1and 1 other:

NZ_FMPI01000012.1 Lanthipeptides: BJR39_RS08305_lanthipeptide

Lanthipeptides: BJR39_RS08305_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

C+TNTFSLSDYWGN GNWCTA+HECM WCK

CSTNTFSLSDYWGNNGNWCTASHECMSWCK

86.7%

NZ_NUIO01000031.1and 1 other:

NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23160_lanthipeptide

Lanthipeptides: CN977_RS23160_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

CTTNTFSLSDYWGN G+WCTATHEC+ WCK

CTTNTFSLSDYWGNDGSWCTATHECLSWCK

83.3%

NZ_CACZYW010000004.1and 1 other:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02825_lanthipeptide

Lanthipeptides: HUF10_RS02825_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

C+TNTFSLSDYWGN GNWCT +HECM WCK

CSTNTFSLSDYWGNNGNWCTLSHECMAWCK

83.3%

NZ_CP027862.1and 1 other:

NZ_CP027862.1 Lanthipeptides: allorf_0097945_0098112_lanthipeptide

Lanthipeptides: allorf_0097945_0098112_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

C+TNTFSLSDYWGN+G WCT THECM WCK

CSTNTFSLSDYWGNRGYWCTLTHECMSWCK

83.3%

NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18440_lanthipeptide

Lanthipeptides: EI692_RS18440_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

C+TNTFSLSDYWGNKG WCT +HECM WCK

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

83.3%

NZ_QGEE01000020.1and 5 others:

NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06160_lanthipeptideNZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptideNZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptide

Lanthipeptides: DKP74_RS06160_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

C+TNTFSLSDYWGN+GNWCT +HECM WCK

CSTNTFSLSDYWGNRGNWCTLSHECMAWCK

80.0%

NZ_CP016767.1and 11 others:

NZ_CP016767.1 Lanthipeptides: BCV50_RS13410_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15325_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15325_lanthipeptideNZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07920_lanthipeptideNZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07920_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00580_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00580_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17015_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17015_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04645_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04645_lanthipeptide

Lanthipeptides: BCV50_RS13410_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWC

CTTNTFSLSDYWGNKG WCT + ECM WC

CTTNTFSLSDYWGNKGGWCTVSKECMAWC

80.0%

NZ_CP051884.1and 2 others:

NZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptide

Lanthipeptides: HGK68_RS15125_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

C+TNTFSLSDYWGN G CT THECM WCK

CSTNTFSLSDYWGNNGWLCTITHECMSWCK

80.0%

NZ_FNHR01000005.1and 1 other:

NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05590_lanthipeptide

Lanthipeptides: BLQ37_RS05590_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

C+TNTFSLSDY GN GNWCT +HECM WCK

CSTNTFSLSDYMGNNGNWCTISHECMAWCK

MIBiG 4.0 matches for FN751_RS00120

63.3%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

CTTNTFSLSDYWGNKGNWCTATHECMGWC

CTTNTFSLS+ GN G WCT T EC C

CTTNTFSLSNALGNNGGWCTLTKECQPNC

40.0%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

FSLSDYWGNKGNWCTATHECMGWC

+++S GNKG +CT T ECM C

YNISCRLGNKGAYCTLTVECMPSC

12.8%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

CTATHECMGWC

CT + EC C

CTLSKECQPNC

FN751_RS00125

Leader:

MNNDKQNEPNVDLELGKYLEADLISLTDDEVTGG

Core:

GTPTITIPISIAVSGWISDKTCPTSVCTRAC

Core with dehydrations:

GDhbPDhbIDhbIPIDhaIAVDhaGWIDhaDKDhbCysPDhbDhaVCysDhbRACys

antiSMASH-DB 4.0 matches for FN751_RS00125

100.0%

NZ_AP026714.1and 21 others:

NZ_AP026714.1 Lanthipeptides: PO853_RS06520_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptide

Lanthipeptides: PO853_RS06520_lanthipeptide

GTPTITIPISIAVSGWISDKTCPTSVCTRAC

61.3%

NZ_CP051884.1and 3 others:

NZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptide

Lanthipeptides: HGK68_RS15130_lanthipeptide

GTPTITIPISIAVSGWISDKTCPTSVCTRAC

GTPT+ + I VS WIS+ TCP+S CTRAC

GTPTVVLSI---VSAWISNNTCPSSACTRAC

61.3%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06335_lanthipeptide

Lanthipeptides: IE339_RS06335_lanthipeptide

TPTITIPISIAVSGWISDKTCPTSVCTRAC

TPTI I AV+G+IS TCPT+ CTRAC

TPTIVI---TAVTGYISTNTCPTTSCTRAC

with 77 more sequence matches

Only the first 10 are displayed here.

61.3%

NZ_NUIO01000031.1and 1 other:

NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23165_lanthipeptide

Lanthipeptides: CN977_RS23165_lanthipeptide

TPTITIPISIAVSGWISDKTCPTSVCTRAC

TPT++I ++ AVSG+IS TCPT+ CTRAC

TPTVSIALT-AVSGYISSNTCPTTACTRAC

54.8%

NZ_CP027862.1and 1 other:

NZ_CP027862.1 Lanthipeptides: C3B71_RS16030_lanthipeptide

Lanthipeptides: C3B71_RS16030_lanthipeptide

TPTITIPISIAVSGWISDKTCPTSVCTRAC

TP + +AV G+IS TCPT+VCTRAC

TPAVATAALLAVGGFISHNTCPTTVCTRAC

54.8%

NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18435_lanthipeptide

Lanthipeptides: EI692_RS18435_lanthipeptide

ITIPISIAVSGWISDKTCPTSVCTRAC

+T ISI VSG+IS TCP++ CTRAC

VTPAISILVSGFISTNTCPSTACTRAC

54.8%

NZ_PCGR01000003.1and 1 other:

NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09625_lanthipeptide

Lanthipeptides: CQS04_RS09625_lanthipeptide

GTPTITIPISIAVSGWISDKTCPTSVCTRAC

TPTI I A++G+IS +CPT+ CTRAC

ATPTIVI---TAITGYISANSCPTTACTRAC

50.0%

NZ_CACZYW010000004.1and 3 others:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide

Lanthipeptides: HUF10_RS02820_lanthipeptide

PISIAVSGWISDKTCPTSVCTRAC

P+ +AVS ++SDKTCPT+ CTRAC

PVIVAVSAYVSDKTCPTTACTRAC

48.4%

NZ_KE384533.1and 2 others:

NZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptideNZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptide

Lanthipeptides: K329_RS31315_lanthipeptide

TPTITIPISIAVSGWISDKTCPTSVCTRAC

TPTI I + VS ++S TCPT+ CT C

TPTIVISV---VSAYVSTNTCPTTSCTDEC

42.4%

NZ_LR134317.1and 1 other:

NZ_LR134317.1 Lanthipeptides: EL136_RS01690_lanthipeptide

Lanthipeptides: EL136_RS01690_lanthipeptide

IPISIAVSGWISDKTCPTSVCTRAC

+ S+AV+ +IS TCPT+ CTRAC

VKASVAVTAFISANTCPTTSCTRAC

42.4%

NZ_MIFN01000022.1and 1 other:

NZ_MIFN01000022.1 Lanthipeptides: BHL26_RS15355_lanthipeptide

Lanthipeptides: BHL26_RS15355_lanthipeptide

AVSGWISDKTCPTSVCTRAC

AVSG+IS TCP++ CTRAC

AVSGYISSNTCPSTACTRAC

41.9%

NZ_CP016767.1and 3 others:

NZ_CP016767.1 Lanthipeptides: BCV50_RS13415_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptide

Lanthipeptides: BCV50_RS13415_lanthipeptide

PISIAVSGWISDKTCPTSVCTRAC

P ++G+IS TCPT+ CTRAC

PALSVITGYISSNTCPTTACTRAC

41.9%

NZ_CP050134.2and 3 others:

NZ_EQ973330.1 Lanthipeptides: CORMATOL_RS14310_lanthipeptideNZ_LR134504.1 Lanthipeptides: EL293_RS13085_lanthipeptideNZ_LR134504.1 Lanthipeptides: EL293_RS13085_lanthipeptide

Lanthipeptides: HBA49_RS00775_lanthipeptide

PTITIPISIAVSGWISDKTCPTSVCTRAC

P+ IPISIA+ CPT+ C+R C

PSTLIPISIAL--------CPTTRCSRRC

MIBiG 4.0 matches for FN751_RS00125

24.3%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

IPISIAVSGWISDKTCPTSVCTRAC

+ I V+ +S CPT+ CT C

VAIQAGVAVGVSAAFCPTTKCTSRC

19.4%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

CPTSVCTRAC

CPT+ CT C

CPTTKCTSKC

allorf_0007795_0007965

Leader:

MVSLKVESRLYQWIAVVVMVRSCLIADTRDKQLAFG

Core:

LVQLPAMIYTFQIWYICYTW

Core with dehydrations:

LVQLPAMIYDhbFQIWYICysYDhbW

allorf_0010114_0010323

Leader:

MDFSLRKEKDIIVFLRTLRSA

Core:

LKTSRGIFPLTGVCLSLCLWRNQNQDPSIRLNAGHLLVAPTLAKDCGN

Core with dehydrations:

LKDhbDhaRGIFPLDhbGVCysLDhaLCysLWRNQNQDPDhaIRLNAGHLLVAPDhbLAKDCysGN

antiSMASH-DB 4.0 matches for allorf_0010114_0010323

23.1%

NZ_BLJO01000007.1:

Lanthipeptides: allorf_032572_032772_lanthipeptide

LWRNQNQDPSIRLNAGH-LLVAPTLA

L + Q+Q IR A H LLVA +L

LNKQQHQRLRIRTTAAHPLLVAGSLG

12.5%

NZ_CP058255.1:

Lanthipeptides: HW369_RS18920_lanthipeptide

APTLAKDCGN

PT+ KDC N

VPTITKDCPN

Lanthipeptide(s) for FN751_RS00140

FN751_RS00120

Leader:

MRDEENNETLINNEQVAWFEEVADQSFDDDVFGA

Core:

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

Core with dehydrations:

CysDhbDhbNDhbFDhaLDhaDYWGNKGNWCysDhbADhbHECysMGWCysK

antiSMASH-DB 4.0 matches for FN751_RS00120

100.0%

NZ_AP026714.1and 21 others:

Lanthipeptides: PO853_RS06515_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

93.3%

NZ_BLIS01000009.1and 7 others:

Lanthipeptides: GVO03_RS04820_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

CTTNTFSLSDYWGNKGNWCT THECM WCK

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

93.3%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06330_lanthipeptide

Lanthipeptides: IE339_RS06330_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

CTTNTFSLSDYWGNKG WCTATHECM WCK

CTTNTFSLSDYWGNKGGWCTATHECMSWCK

with 105 more sequence matches

Only the first 10 are displayed here.

93.3%

NZ_PCGR01000003.1and 1 other:

NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09620_lanthipeptide

Lanthipeptides: CQS04_RS09620_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

CTTNTFSLSDYWGN GNWCTATHECM WCK

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

86.7%

NZ_FMPI01000012.1and 1 other:

NZ_FMPI01000012.1 Lanthipeptides: BJR39_RS08305_lanthipeptide

Lanthipeptides: BJR39_RS08305_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

C+TNTFSLSDYWGN GNWCTA+HECM WCK

CSTNTFSLSDYWGNNGNWCTASHECMSWCK

86.7%

NZ_NUIO01000031.1and 1 other:

NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23160_lanthipeptide

Lanthipeptides: CN977_RS23160_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

CTTNTFSLSDYWGN G+WCTATHEC+ WCK

CTTNTFSLSDYWGNDGSWCTATHECLSWCK

83.3%

NZ_CACZYW010000004.1and 1 other:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02825_lanthipeptide

Lanthipeptides: HUF10_RS02825_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

C+TNTFSLSDYWGN GNWCT +HECM WCK

CSTNTFSLSDYWGNNGNWCTLSHECMAWCK

83.3%

NZ_CP027862.1and 1 other:

NZ_CP027862.1 Lanthipeptides: allorf_0097945_0098112_lanthipeptide

Lanthipeptides: allorf_0097945_0098112_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

C+TNTFSLSDYWGN+G WCT THECM WCK

CSTNTFSLSDYWGNRGYWCTLTHECMSWCK

83.3%

NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18440_lanthipeptide

Lanthipeptides: EI692_RS18440_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

C+TNTFSLSDYWGNKG WCT +HECM WCK

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

83.3%

NZ_QGEE01000020.1and 5 others:

Lanthipeptides: DKP74_RS06160_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

C+TNTFSLSDYWGN+GNWCT +HECM WCK

CSTNTFSLSDYWGNRGNWCTLSHECMAWCK

80.0%

NZ_CP016767.1and 11 others:

Lanthipeptides: BCV50_RS13410_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWC

CTTNTFSLSDYWGNKG WCT + ECM WC

CTTNTFSLSDYWGNKGGWCTVSKECMAWC

80.0%

NZ_CP051884.1and 2 others:

NZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptide

Lanthipeptides: HGK68_RS15125_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

C+TNTFSLSDYWGN G CT THECM WCK

CSTNTFSLSDYWGNNGWLCTITHECMSWCK

80.0%

NZ_FNHR01000005.1and 1 other:

NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05590_lanthipeptide

Lanthipeptides: BLQ37_RS05590_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

C+TNTFSLSDY GN GNWCT +HECM WCK

CSTNTFSLSDYMGNNGNWCTISHECMAWCK

MIBiG 4.0 matches for FN751_RS00120

63.3%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

CTTNTFSLSDYWGNKGNWCTATHECMGWC

CTTNTFSLS+ GN G WCT T EC C

CTTNTFSLSNALGNNGGWCTLTKECQPNC

40.0%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

FSLSDYWGNKGNWCTATHECMGWC

+++S GNKG +CT T ECM C

YNISCRLGNKGAYCTLTVECMPSC

12.8%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

CTATHECMGWC

CT + EC C

CTLSKECQPNC

FN751_RS00125

Leader:

MNNDKQNEPNVDLELGKYLEADLISLTDDEVTGG

Core:

GTPTITIPISIAVSGWISDKTCPTSVCTRAC

Core with dehydrations:

GDhbPDhbIDhbIPIDhaIAVDhaGWIDhaDKDhbCysPDhbDhaVCysDhbRACys

antiSMASH-DB 4.0 matches for FN751_RS00125

100.0%

NZ_AP026714.1and 21 others:

Lanthipeptides: PO853_RS06520_lanthipeptide

GTPTITIPISIAVSGWISDKTCPTSVCTRAC

61.3%

NZ_CP051884.1and 3 others:

NZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptide

Lanthipeptides: HGK68_RS15130_lanthipeptide

GTPTITIPISIAVSGWISDKTCPTSVCTRAC

GTPT+ + I VS WIS+ TCP+S CTRAC

GTPTVVLSI---VSAWISNNTCPSSACTRAC

61.3%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06335_lanthipeptide

Lanthipeptides: IE339_RS06335_lanthipeptide

TPTITIPISIAVSGWISDKTCPTSVCTRAC

TPTI I AV+G+IS TCPT+ CTRAC

TPTIVI---TAVTGYISTNTCPTTSCTRAC

with 77 more sequence matches

Only the first 10 are displayed here.

61.3%

NZ_NUIO01000031.1and 1 other:

NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23165_lanthipeptide

Lanthipeptides: CN977_RS23165_lanthipeptide

TPTITIPISIAVSGWISDKTCPTSVCTRAC

TPT++I ++ AVSG+IS TCPT+ CTRAC

TPTVSIALT-AVSGYISSNTCPTTACTRAC

54.8%

NZ_CP027862.1and 1 other:

NZ_CP027862.1 Lanthipeptides: C3B71_RS16030_lanthipeptide

Lanthipeptides: C3B71_RS16030_lanthipeptide

TPTITIPISIAVSGWISDKTCPTSVCTRAC

TP + +AV G+IS TCPT+VCTRAC

TPAVATAALLAVGGFISHNTCPTTVCTRAC

54.8%

NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18435_lanthipeptide

Lanthipeptides: EI692_RS18435_lanthipeptide

ITIPISIAVSGWISDKTCPTSVCTRAC

+T ISI VSG+IS TCP++ CTRAC

VTPAISILVSGFISTNTCPSTACTRAC

54.8%

NZ_PCGR01000003.1and 1 other:

NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09625_lanthipeptide

Lanthipeptides: CQS04_RS09625_lanthipeptide

GTPTITIPISIAVSGWISDKTCPTSVCTRAC

TPTI I A++G+IS +CPT+ CTRAC

ATPTIVI---TAITGYISANSCPTTACTRAC

50.0%

NZ_CACZYW010000004.1and 3 others:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide

Lanthipeptides: HUF10_RS02820_lanthipeptide

PISIAVSGWISDKTCPTSVCTRAC

P+ +AVS ++SDKTCPT+ CTRAC

PVIVAVSAYVSDKTCPTTACTRAC

48.4%

NZ_KE384533.1and 2 others:

NZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptideNZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptide

Lanthipeptides: K329_RS31315_lanthipeptide

TPTITIPISIAVSGWISDKTCPTSVCTRAC

TPTI I + VS ++S TCPT+ CT C

TPTIVISV---VSAYVSTNTCPTTSCTDEC

42.4%

NZ_LR134317.1and 1 other:

NZ_LR134317.1 Lanthipeptides: EL136_RS01690_lanthipeptide

Lanthipeptides: EL136_RS01690_lanthipeptide

IPISIAVSGWISDKTCPTSVCTRAC

+ S+AV+ +IS TCPT+ CTRAC

VKASVAVTAFISANTCPTTSCTRAC

42.4%

NZ_MIFN01000022.1and 1 other:

NZ_MIFN01000022.1 Lanthipeptides: BHL26_RS15355_lanthipeptide

Lanthipeptides: BHL26_RS15355_lanthipeptide

AVSGWISDKTCPTSVCTRAC

AVSG+IS TCP++ CTRAC

AVSGYISSNTCPSTACTRAC

41.9%

NZ_CP016767.1and 3 others:

NZ_CP016767.1 Lanthipeptides: BCV50_RS13415_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptide

Lanthipeptides: BCV50_RS13415_lanthipeptide

PISIAVSGWISDKTCPTSVCTRAC

P ++G+IS TCPT+ CTRAC

PALSVITGYISSNTCPTTACTRAC

41.9%

NZ_CP050134.2and 3 others:

NZ_EQ973330.1 Lanthipeptides: CORMATOL_RS14310_lanthipeptideNZ_LR134504.1 Lanthipeptides: EL293_RS13085_lanthipeptideNZ_LR134504.1 Lanthipeptides: EL293_RS13085_lanthipeptide

Lanthipeptides: HBA49_RS00775_lanthipeptide

PTITIPISIAVSGWISDKTCPTSVCTRAC

P+ IPISIA+ CPT+ C+R C

PSTLIPISIAL--------CPTTRCSRRC

MIBiG 4.0 matches for FN751_RS00125

24.3%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

IPISIAVSGWISDKTCPTSVCTRAC

+ I V+ +S CPT+ CT C

VAIQAGVAVGVSAAFCPTTKCTSRC

19.4%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

CPTSVCTRAC

CPT+ CT C

CPTTKCTSKC

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 28.19 out of 30.25

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 25.49 out of 30.25

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.56 out of 25.88

Confidence: medium

Additional weak hits (4):

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 22.19 out of 29.51

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 24.23 out of 35.63

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 16.52 out of 30.12

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 24.25 out of 36.53

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

FN751_RS00120 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 3317.4 Da

Molecular weight: 3319.7 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3337.7 Da N = 1; 3355.7 Da N = 2; 3373.7 Da N = 3

FN751_RS00125 - Class II

Cleavage pHMM score: -1.70

RODEO score: 0

Monoisotopic mass: 2997.6 Da

Molecular weight: 2999.5 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3017.5 Da N = 1; 3035.5 Da N = 2; 3053.5 Da N = 3; 3071.6 Da N = 4; 3089.6 Da N = 5; 3107.6 Da N = 6; 3125.6 Da N = 7

allorf_0007795_0007965 - Class II

Cleavage pHMM score: -1.90

RODEO score: 0

Monoisotopic mass: 2515.3 Da

Molecular weight: 2517.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2535.0 Da N = 1

allorf_0010114_0010323 - Class II

Cleavage pHMM score: -7.10

RODEO score: 0

Monoisotopic mass: 5094.7 Da

Molecular weight: 5097.9 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 5115.9 Da N = 1; 5134.0 Da N = 2; 5152.0 Da N = 3

FN751_RS00120 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 3317.4 Da

Molecular weight: 3319.7 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3337.7 Da N = 1; 3355.7 Da N = 2; 3373.7 Da N = 3

FN751_RS00125 - Class II

Cleavage pHMM score: -1.70

RODEO score: 0

Monoisotopic mass: 2997.6 Da

Molecular weight: 2999.5 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3017.5 Da N = 1; 3035.5 Da N = 2; 3053.5 Da N = 3; 3071.6 Da N = 4; 3089.6 Da N = 5; 3107.6 Da N = 6; 3125.6 Da N = 7

TFBS definitions

Regulator	Description
ColR	Phenol-responsive regulator
PsrA	Oleic acid responsive regulator

NZ_LR607378.1 - Region 2 - cyclic-lactone-autoinducer

Download region GenBank file

Download region SVG

Location: 727,105 - 747,833 nt. (total: 20,729 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001291.3	0.41	ribosomal	enterocin NKR-5-3B	Enterococcus faecium
BGC0001948.3	0.37	other (other)	naseseazine C, C3-aryl pyrroloindolines	Streptomyces sp.
BGC0000046.4	0.35	PKS	depudecin	Alternaria brassicicola
BGC0002227.3	0.31	NRPS	AKML B, AKML D, AKML A, AKML C	Aspergillus luchuensis IFO 4308
BGC0002667.2	0.30	ribosomal	estericin A	Clostridium estertheticum
BGC0001246.3	0.30	PKS	trans-resorcylide	Sarocladium zeae
BGC0000688.4	0.29	terpene	copalyl diphosphate	Diaporthe amygdali
BGC0001954.2	0.28	NRPS, PKS	wortmanamide A, wortmanamide B	Talaromyces wortmannii
BGC0001366.5	0.27	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0002058.3	0.27	NRPS, PKS	mutanocyclin	Streptococcus mutans B04Sm5

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001291.3	0.41	ribosomal	enterocin NKR-5-3B	Enterococcus faecium
BGC0001948.3	0.37	other (other)	naseseazine C, C3-aryl pyrroloindolines	Streptomyces sp.
BGC0000046.4	0.35	PKS	depudecin	Alternaria brassicicola
BGC0002227.3	0.31	NRPS	AKML B, AKML D, AKML A, AKML C	Aspergillus luchuensis IFO 4308
BGC0002667.2	0.30	ribosomal	estericin A	Clostridium estertheticum
BGC0001246.3	0.30	PKS	trans-resorcylide	Sarocladium zeae
BGC0000688.4	0.29	terpene	copalyl diphosphate	Diaporthe amygdali
BGC0001954.2	0.28	NRPS, PKS	wortmanamide A, wortmanamide B	Talaromyces wortmannii
BGC0001366.5	0.27	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0002058.3	0.27	NRPS, PKS	mutanocyclin	Streptococcus mutans B04Sm5

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 28.99 out of 30.25

Confidence: strong

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.08 out of 23.79

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.50 out of 23.79

Confidence: medium

Additional weak hits (1):

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 20.68 out of 29.72

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
ColR	Phenol-responsive regulator
IolR	Regulator of the inositol catabolism

NZ_LR607378.1 - Region 3 - NRPS,arylpolyene

Download region GenBank file

Download region SVG

Location: 1,840,076 - 1,884,372 nt. (total: 44,297 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
arylpolyene: (APE_KS1 or APE_KS2)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

FN751_RS09275: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

FN751_RS09330: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: PPTase transferase

FN751_RS09295: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

FN751_RS09300: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

FN751_RS09375: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Lyases: decarboxylase

FN751_RS09255: Decarboxylase, pyridoxal-dependent

smcogs: SMCOG1180: Decarboxylase, pyridoxal-dependent

Ligases: ligase synthase

FN751_RS09305: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

FN751_RS09310: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Translocases: permease

FN751_RS09250: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001261.3	0.58	NRPS	AM-toxin	Alternaria alternata
BGC0001166.5	0.57	NRPS	HC-toxin	Alternaria jesenskae
BGC0002286.3	0.54	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000836.5	0.38	other (other)	APE Ec	Escherichia coli CFT073
BGC0002008.3	0.38	other (other)	aryl polyenes	Xenorhabdus doucetiae
BGC0000837.4	0.37	other (other)	APE Vf	Aliivibrio fischeri ES114
BGC0000888.5	0.34	other (other)	bacilysin	Bacillus sp. CS93
BGC0001928.2	0.33	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0002518.3	0.32	NRPS	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0002547.2	0.32	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces youssoufiensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001261.3	0.62	NRPS	AM-toxin	Alternaria alternata
BGC0001166.5	0.62	NRPS	HC-toxin	Alternaria jesenskae
BGC0002286.3	0.61	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000836.5	0.51	other (other)	APE Ec	Escherichia coli CFT073
BGC0002008.3	0.51	other (other)	aryl polyenes	Xenorhabdus doucetiae
BGC0000837.4	0.50	other (other)	APE Vf	Aliivibrio fischeri ES114
BGC0000888.5	0.49	other (other)	bacilysin	Bacillus sp. CS93
BGC0001928.2	0.48	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0002518.3	0.47	NRPS	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0002547.2	0.47	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces youssoufiensis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.48 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.28 out of 27.78

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.27 out of 26.06

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.99 out of 30.25

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.31 out of 30.25

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.37 out of 29.38

Confidence: medium

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 29.42 out of 32.74

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.54 out of 26.06

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.93 out of 30.25

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 21.07 out of 25.31

Confidence: medium

Additional weak hits (3):

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 23.73 out of 29.65

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.24 out of 39.62

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 19.58 out of 27.18

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 3, location 1840075 - 1884372:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

FN751_RS09305: X

AMP-binding (15..416): X

nrpys: Gly, Ala, Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LGMAFDPSIAQFDIISCGEFNFYGPSECSVYSTV
Nearest Stachelhaus code(s):: Cap DPQDIGIVNK (50% 8Å match)
Stachelhaus code match:: 60% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CatR	H2O2-responsive repressor
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
FuR variant 1	Ferric Uptake Regulator
FuR variant 2	Ferric Uptake Regulator
MogR	Repressor of flagellar motility genes

NZ_LR607378.1 - Region 4 - terpene-precursor

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Location: 2,093,323 - 2,114,204 nt. (total: 20,882 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: peptidase

FN751_RS10640: methionine aminopeptidase

smcogs: SMCOG1172: methionine aminopeptidase

Ligases: synthetase

FN751_RS10605: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002309.2	0.36	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000639.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0001605.3	0.32	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001075.5	0.31	PKS, terpene	aurachin RE	Rhodococcus erythropolis
BGC0001456.3	0.30	terpene	isorenieratene	Streptomyces argillaceus
BGC0000286.3	0.30	PKS	viguiepinol	Streptomyces sp. KO-3988

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002309.2	0.36	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000639.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0001605.3	0.32	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001075.5	0.31	PKS, terpene	aurachin RE	Rhodococcus erythropolis
BGC0001456.3	0.30	terpene	isorenieratene	Streptomyces argillaceus
BGC0000286.3	0.30	PKS	viguiepinol	Streptomyces sp. KO-3988

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

FN751_RS10605: PT_FPPS_like

Domain 1 (29 - 276): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.38 out of 27.78

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.89 out of 25.88

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.25 out of 27.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.87 out of 28.19

Confidence: medium

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
PsrA	Oleic acid responsive regulator
ZuR variant 1	Zinc-responsive repressor