LOCUS       NZ_LR607361            27848 bp    DNA     linear   CON 14-FEB-2024
DEFINITION  Enterococcus faecalis strain 4928STDY7387713 chromosome 1.
ACCESSION   NZ_LR607361
VERSION     NZ_LR607361.1
KEYWORDS    RefSeq.
SOURCE      Enterococcus faecalis
  ORGANISM  Enterococcus faecalis
            Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
            Enterococcus.
REFERENCE   1
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (08-JUL-2019) WTSI, Pathogen Informatics, Wellcome Trust
            Sanger Institute, CB10 1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/14/2024 00:48:03
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,659
            CDSs (total)                      :: 2,598
            Genes (coding)                    :: 2,566
            CDSs (with protein)               :: 2,566
            Genes (RNA)                       :: 61
            rRNAs                             :: 4, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 51
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 32
            CDSs (without protein)            :: 32
            Pseudo Genes (ambiguous residues) :: 0 of 32
            Pseudo Genes (frameshifted)       :: 14 of 32
            Pseudo Genes (incomplete)         :: 15 of 32
            Pseudo Genes (internal stop)      :: 7 of 32
            Pseudo Genes (multiple problems)  :: 4 of 32
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:58:48
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1042366
            Orig. end                         :: 1070214
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LR607361.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..27848
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..27848
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27848
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:17848](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..17848
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     tRNA            1008..1080
                     /anticodon=(pos:1043407..1043409,aa:Ala,seq:tgc)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="FN738_RS03660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Ala"
     gene            1008..1080
                     /locus_tag="FN738_RS03660"
     assembly_gap    1268..5488
                     /estimated_length=4221
                     /gap_type="unknown"
                     /linkage_evidence="unspecified"
     rRNA            5517..5632
                     /db_xref="RFAM:RF00001"
                     /gene="rrf"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00001"
                     /inference="COORDINATES: profile:INFERNAL:1.1.4"
                     /locus_tag="FN738_RS03665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /product="5S ribosomal RNA"
     gene            5517..5632
                     /gene="rrf"
                     /locus_tag="FN738_RS03665"
     tRNA            5639..5712
                     /anticodon=(pos:1048039..1048041,aa:Asn,seq:gtt)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="FN738_RS03670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Asn"
     gene            5639..5712
                     /locus_tag="FN738_RS03670"
     misc_feature    complement(5752..5771)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 19.89"
                     /tool="antismash"
     tRNA            5756..5844
                     /anticodon=(pos:1048156..1048158,aa:Ser,seq:gga)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="FN738_RS03675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Ser"
     gene            5756..5844
                     /locus_tag="FN738_RS03675"
     tRNA            5862..5933
                     /anticodon=(pos:1048261..1048263,aa:Glu,seq:ttc)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="FN738_RS03680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Glu"
     gene            5862..5933
                     /locus_tag="FN738_RS03680"
     tRNA            5961..6033
                     /anticodon=(pos:1048360..1048362,aa:Val,seq:tac)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="FN738_RS03685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Val"
     gene            5961..6033
                     /locus_tag="FN738_RS03685"
     tRNA            6044..6119
                     /anticodon=(pos:1048443..1048445,aa:Asp,seq:gtc)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="FN738_RS03690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Asp"
     gene            6044..6119
                     /locus_tag="FN738_RS03690"
     tRNA            6165..6237
                     /anticodon=(pos:1048564..1048566,aa:Phe,seq:gaa)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="FN738_RS03695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Phe"
     gene            6165..6237
                     /locus_tag="FN738_RS03695"
     CDS             6168..6293
                     /gene="allorf_1048534_1048659"
                     /locus_tag="allorf_1048534_1048659"
                     /protein_id="allorf_1048534_1048659"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MVAQLVEQRIEAPCVGSSTLSHAIYGGIAKWLNATDCKSVP"
     CDS_motif       6168..6248
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MVAQLVEQRIEAPCVGSSTLSHAIYGG"
                     /locus_tag="allorf_1048534_1048659_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       6249..6293
                     /prepeptide="core"
                     /locus_tag="allorf_1048534_1048659_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.90"
                     /molecular_weight="1509.8"
                     /monoisotopic_mass="1508.8"
                     /core_sequence="IAKWLNATDCKSVP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MVAQLVEQRIEAPCVGSSTLSHAIYGG"
                     /leader_location="[6167:6248](+)"
                     /alternative_weights="1527.8"
     tRNA            6243..6323
                     /anticodon=(pos:1048643..1048645,aa:Tyr,seq:gta)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="FN738_RS03700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Tyr"
     gene            6243..6323
                     /locus_tag="FN738_RS03700"
     tRNA            6328..6401
                     /anticodon=(pos:1048726..1048728,aa:Trp,seq:cca)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="FN738_RS03705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Trp"
     gene            6328..6401
                     /locus_tag="FN738_RS03705"
     tRNA            6438..6510
                     /anticodon=(pos:1048837..1048839,aa:His,seq:gtg)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="FN738_RS03710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-His"
     gene            6438..6510
                     /locus_tag="FN738_RS03710"
     tRNA            6525..6596
                     /anticodon=(pos:1048923..1048925,aa:Gln,seq:ttg)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="FN738_RS03715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Gln"
     gene            6525..6596
                     /locus_tag="FN738_RS03715"
     tRNA            6622..6692
                     /anticodon=(pos:1049020..1049022,aa:Cys,seq:gca)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="FN738_RS03720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Cys"
     gene            6622..6692
                     /locus_tag="FN738_RS03720"
     tRNA            6706..6789
                     /anticodon=(pos:1049106..1049108,aa:Leu,seq:caa)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="FN738_RS03725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Leu"
     gene            6706..6789
                     /locus_tag="FN738_RS03725"
     misc_feature    complement(6762..6776)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 16.52"
                     /tool="antismash"
     gene            7091..>8803
                     /locus_tag="FN738_RS03730"
                     /pseudo=""
     CDS             7091..>8803
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002390873.1"
                     /locus_tag="FN738_RS03730"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="SpaA isopeptide-forming pilin-related protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRRPRIKNSKLLAALVLLFQTVNTGITPLIAHAEERNYPEEVTIE
                     YDANNIYNVSGVYNNGKVFNTHTAPTYANYKGKKQPVFCIEPEVNIINPVNPGYEKNPL
                     PDMPDRAKLVSILWKKVGQDPDTQAVAQKIIWQAANGYTIHTMSRPDGSTVDIPSIEAK
                     INKVVQDYQKKPSFDGTTTKLNLGKSTVLTDTNQLNLSEFDKVVENTANIDYHVNGNQL
                     TLSTNEQSKSGVLTLEKSEGKGTPVAYKKAGVQTVMAGAIDKPTTYTVKLDIETKGKLK
                     ITKIDKESGKKLPGTVFHLDFGGKFPTQEVTTGDDGTSLIEGIPHNTKVTITEKSVPAP
                     YTIDPTPLSATIKAGETIEKVSKNLREKGQIVLDKKGVETGTTLWNEHYSLAGNQFEIR
                     KETSDGPIVQTIITDAKGHAETSKDVLKALELGTYYVTESKASAGFVNTFKPVKVVLAY
                     QNQTVPISVEYVKGTNQEITGQTTLTKEDKDTGADTQGNATFKGAQYTLFYGETNQNHA
                     KDTPVKWQDESHPEVIKGKKASEQEVTLTIDKENQVGVKHLAISNYYWKETKAP"
     gene            9560..9754
                     /locus_tag="FN738_RS03735"
     CDS             9560..9754
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_ha"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018165752.1"
                     /locus_tag="FN738_RS03735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="plantaricin C family lantibiotic"
                     /protein_id="WP_010824504.1"
                     /sec_met_domain="mature_ha (E-value: 3.4e-12, bitscore:
                     43.0, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRDEENNETLINNEQVAWFEEVADQSFDDDVFGACTTNTFSLSDY
                     WGNKGNWCTATHECMGWCK"
     CDS_motif       9560..9661
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MRDEENNETLINNEQVAWFEEVADQSFDDDVFGA"
                     /locus_tag="FN738_RS03735_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9662..9754
                     /prepeptide="core"
                     /locus_tag="FN738_RS03735_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="2.00"
                     /molecular_weight="3319.7"
                     /monoisotopic_mass="3317.4"
                     /core_sequence="CTTNTFSLSDYWGNKGNWCTATHECMGWCK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRDEENNETLINNEQVAWFEEVADQSFDDDVFGA"
                     /leader_location="[9559:9661](+)"
                     /alternative_weights="3337.7"
                     /alternative_weights="3355.7"
                     /alternative_weights="3373.7"
     gene            9778..9975
                     /locus_tag="FN738_RS03740"
     CDS             9778..9975
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038161.1"
                     /locus_tag="FN738_RS03740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class II lanthipeptide, LchA2/BrtA2 family"
                     /protein_id="WP_142963513.1"
                     /transl_table=11
                     /translation="MNNDKQNEQNVDLELGKYLEADLISLTDDEVTGGGTPTITIPISI
                     AVSGWISDKTCPTSVCTRAC"
     CDS_motif       9778..9879
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MNNDKQNEQNVDLELGKYLEADLISLTDDEVTGG"
                     /locus_tag="FN738_RS03740_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9880..9975
                     /prepeptide="core"
                     /locus_tag="FN738_RS03740_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-1.70"
                     /molecular_weight="2999.5"
                     /monoisotopic_mass="2997.6"
                     /core_sequence="GTPTITIPISIAVSGWISDKTCPTSVCTRAC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNNDKQNEQNVDLELGKYLEADLISLTDDEVTGG"
                     /leader_location="[9777:9879](+)"
                     /alternative_weights="3017.5"
                     /alternative_weights="3035.5"
                     /alternative_weights="3053.5"
                     /alternative_weights="3071.6"
                     /alternative_weights="3089.6"
                     /alternative_weights="3107.6"
                     /alternative_weights="3125.6"
     gene            10001..12922
                     /gene="lanM"
                     /locus_tag="FN738_RS03745"
     CDS             10001..12922
                     /GO_process="GO:0009403 - toxin biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0018081 - peptide cross-linking via
                     lanthionine or 3-methyl-lanthionine [Evidence IEA]"
                     /GO_process="GO:0018193 - peptidyl-amino acid modification
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="lanM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="FN738_RS03745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type 2 lanthipeptide synthetase LanM"
                     /protein_id="WP_033600438.1"
                     /sec_met_domain="DUF4135 (E-value: 2.8e-66, bitscore:
                     221.5, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.3e-47, bitscore:
                     159.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVVYSKKVYPELELKDYNEHILPIVHYIEQLNLKKLIELPTIVNY
                     KTEEKYPYYNVCMSITSEIWDKVWNNKLDAYVHNPLSFKEAICDDLSQVAFSYMIRGFS
                     EHIKLLQNVELENSYLLYNETLKRNKMKEFSETYFVTWNRCINLIISRINSIVDTVKRI
                     QQYRIDIEKKFNINRDLKIVYVKSDGDTHNDGSSVSIIYFEDKQKIIYKPRSVSGEAGY
                     TKLIMAINYKFNLNLPVLSVINCGNYGFTSFETSDETQVDMYKAGQLACLMYLLNASDM
                     HYSNILWTHKGPLPIDLETLFHPSRNRSGIPESSNSAYDSLEKSVYGTGVLPISISDKN
                     KSGSVDVGFTGIRDKNSVSPFKTFELINGFNSNIKVVWHNSATVSEDLINDSEYEKQIY
                     ENCAKVVDGFTDVYLLILKNKEFFSKEVITSFKGAKLRYIHNMTYRYEQILRVLTATEP
                     SKDLDMAHSLLSRIGILSMTSDKNITKSECSQLWKGDIPYFTINFDGTEIHSNNDIVST
                     VKNSPQSEFIRKMKKLSQKDLINQQQIIQLAFVAKLADPHAEGKLKLEELENGNQKAIE
                     KKSDGLKKTTEIIKTIKWFSQNLLNSVLDDRYEHLPKTWVGAVAKNGNNGWTPGVLGYD
                     LYSGRIGPALVLSIVGNQFSDIEATNISNDIFEKSAQILENQSFELRNVLLSGTGAFSG
                     ISGLLWAMYHAGTITNNQRWKNVAINSWELLRMDLETVDNNFFDMINGKSGAIIMRLQM
                     QDTFHPKQEFLDKCVNLAYEKINEIDSYMTSGVAHGLGHLLWFFSIINQRIKDNKIKKL
                     IIDIDTAIKKNYTNKEGVIETYLTEQNEHVSSSWCNGLSGLLIAYYEAYKADALPKVSV
                     ISVINQLKTIPISCVPVLCHGSLGVLTALEYVHESFPEETKILIHNIKNTFCSPTYIYE
                     YFKEGKGRYTLSPGLMSGKAGALLHLCKLANSDLKISPLLLGV"
     gene            12924..15083
                     /locus_tag="FN738_RS03750"
     CDS             12924..15083
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018165754.1"
                     /locus_tag="FN738_RS03750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_010824507.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.3e-34, bitscore:
                     116.2, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNFIFKNKRKLKPTIQVAQTECGLCCVRTILEAYGCHKKLTDLR
                     QIKEPGRDGLGLTQLKELLMHMGMDVQTYKIKDLRAFEVVDFPIIAFWKGYHFVCIELF
                     SEKYVIIMDPSIGRIKISINEFQKDFSQYILVAKPNKNFVKVKKNKLDTWKKDYIWPNN
                     MMSLYLGLLMTSIILVIMTLSIPIFTQSLIDKSSYLNSISFVKTIELLLLAIITMIGLN
                     TFRSYLSIKISYKFNWHLLVGAFAHTLSLPAKFFTVRSPGEVIFRLNSLTRIQDVLGIT
                     LVQTFLDIVSSIVILGYIFWSSWTLGIIIVTLIMFMFLFLIITQKYVDSATDKELREGS
                     SVQSIQLDALASINSVKLGGYVQSYFSDWKDKLTKLLSASSHRMYLQQGIVGSVLYGMQ
                     TIFPLIILVISLYQEKLGTLSLGQVIAIQSTVSMLFNYSNTIFSTLSNIMVVERYIELS
                     EDIFDYPIESSVRSDHIMESGNLSINNLYFQYTSDTKPALKNINLKILDGETVAFVGVS
                     GSGKTTLAKICSSLFEPTKGDIFFSDINFQRYNLDQLRKSISYIPQEAHLHNRTIIENL
                     KLGSQLSEEKIIELCSSLEFLSFISDLPMGYNTVISEMGANLSGGQRQRIHIARAILQN
                     PKILIMDEATSSLDNISQSSVYTELSKLECTKIVIAHRLETILNADKIFVLRDGEIVQT
                     GHHNDLVQQPGDYKDLFNTVIEKEK"
     gene            15086..17848
                     /gene="lanM"
                     /locus_tag="FN738_RS03755"
     CDS             15086..17848
                     /GO_process="GO:0009403 - toxin biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0018081 - peptide cross-linking via
                     lanthionine or 3-methyl-lanthionine [Evidence IEA]"
                     /GO_process="GO:0018193 - peptidyl-amino acid modification
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="lanM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="FN738_RS03755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type 2 lanthipeptide synthetase LanM"
                     /protein_id="WP_172616627.1"
                     /sec_met_domain="DUF4135 (E-value: 3.6e-72, bitscore:
                     240.9, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 9.9e-25, bitscore:
                     84.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHNDNKLVNIIEDIFKDIVEHTHTTLKRSFTTFQEKETEVFIKCF
                     HALIEYHINRVVQKTFIYEFHEFRKSLNMPANPNSSVAFDLFLQKLDKQMVEKWLNKYS
                     YLRTIIHTIINNTSLYIIAVCKNFKEDIDQLNNNEMISKNSYLTAINALDSDPHNGSKI
                     VLCFEFSNEEKILYKPRSLEIDQLIDTIFSDILKFKGLKYNTPIAQTICRNSYGWQKFI
                     SHTFIDEADLSEAYYNLGLCAAVFRSIGATDLHDENVIFNGTTPYFIDLETSLKPSHEE
                     INEDSIWDVLNKELSNSIANTCIIPAKLMVAPHNILIGAINTPYPQKTEELCFTLTNPG
                     TDAVDISKQNIIVSRDSAPIMLEKNKFPSPLPYQQDFVNGYEEGIKSVIVNREKISDLL
                     SSFPCTSRIIVRPTVQYFFLLDACLYPENLIDESAIDKILSYMKPSKMFTESENASKVL
                     EAEKKALKKGDIPYFSIGSNKHTINLMNINTNTFEMSPIENALYSLNNLSDRALLIDKR
                     LIAEGFSEIRIHEATFENNKTKKSQAKMFTDVLKEVTIDNPDALFKLIINQSITTKSKN
                     AETGWLNGVYGDMNIAYNSISCISLHDAGGILFLLKHLTEYKKCVDDIETNELYIRASK
                     GVNSLKNTIYGSTEVSNTPMSIISGSNSLEFLFNYEQKKLKYLDKTISKIQLENIESGD
                     VFLGPIGIALVNATFPNTSIDNIIYFTEKFHNTKLPSEGIAHGNLGVLWTNFRLNYALD
                     RLDICKNIFHETTRIKFEESVENVGWCNGNSGLLMVLTEMATLLKVDINLFDLAKKSTI
                     LPLETPLDLSICHGVSGVLQSLLFSFKVSKKSEYIMLANEYWLSVLKLIDINGYYTGEK
                     NRDYLLGYFLGWSGMADSALLLKMYNEGSSPLIPLNLSSLDYQKKLMEV"
     gene            17852..18937
                     /locus_tag="FN738_RS03760"
     CDS             17852..18937
                     /NRPS_PKS="Domain: PKS_ER (48-175). E-value: 2.4e-12.
                     Score: 38.5. Matches aSDomain:
                     nrpspksdomains_FN738_RS03760_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019845.4"
                     /locus_tag="FN738_RS03760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="zinc-binding alcohol dehydrogenase family
                     protein"
                     /protein_id="WP_050444132.1"
                     /sec_met_domain="ADH_N (E-value: 1.1e-05, bitscore: 22.6,
                     seeds: 66, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKALVAINPRYKNSLEFKKMETVKFGSTNVLFGLVELNQPDFDIN
                     NLQNDDYILIKVKYFSCNYRDKSILLEAYISEKNENRLFFPFGSEFSAEIIKIGKNVNN
                     FNVGDFVMPNCEYPHGVKPGIPSNFASLGWLKIHKSKVIKIPARLSLEEAACFSLGSQT
                     ASSMIRRSNILKESGNPVVFSARSATSMFIIRQLLIQGITPICISTTSWTDFEKEYIYP
                     CEVERLEDVSLQAMKRNITHVFDPFFDLNVENAVNLLQIGGTYITCGLLNQHPLLSEKI
                     PIENEPILRRALSMGVMKNITFIGNCLGTYEDLQNAISLEERFSVKPVIDKSYNVNQYL
                     DFINRSFFNANKIGKVSLTYH"
     aSDomain        17996..18376
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FN738_RS03760_PKS_ER.1"
                     /evalue="2.40E-12"
                     /label="FN738_RS03760_PKS_ER.1"
                     /locus_tag="FN738_RS03760"
                     /protein_end="175"
                     /protein_start="48"
                     /score="38.5"
                     /tool="antismash"
                     /translation="NDDYILIKVKYFSCNYRDKSILLEAYISEKNENRLFFPFGSEFSA
                     EIIKIGKNVNNFNVGDFVMPNCEYPHGVKPGIPSNFASLGWLKIHKSKVIKIPARLSLE
                     EAACFSLGSQTASSMIRRSNILK"
     misc_feature    complement(19029..19044)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: strong, score: 28.19"
                     /tool="antismash"
     gene            19412..19654
                     /locus_tag="FN738_RS03765"
     CDS             19412..19654
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002814620.1"
                     /locus_tag="FN738_RS03765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_010824510.1"
                     /transl_table=11
                     /translation="MKKKIHEESIRNKVYEYRVLARLSQQELADRVGVSKQTIFVMEKG
                     NYVPSLLLAFRISNFFNVPLTEIFEYDLGGQNNDE"
     gene            19644..19982
                     /locus_tag="FN738_RS03770"
     CDS             19644..19982
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002814618.1"
                     /locus_tag="FN738_RS03770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_010824511.1"
                     /transl_table=11
                     /translation="MMNKSIGFSFNALNEWSEKSIGNYNLLIGVGFLLVMISSITLVYL
                     LLKLGQRDERTTKIHLNVCCYMLVTIVLCDLFFPKEYMQNILFLFKYALAFSISLIYLL
                     KKYKQDLC"
     gene            20037..20900
                     /locus_tag="FN738_RS03775"
     CDS             20037..20900
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="FN738_RS03775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_010824512.1"
                     /transl_table=11
                     /translation="MNINKVSKSYNNTSVLDNISFNFKKGEIIGLVGRNGAGKSTLMKI
                     ITENILNFNGSIMRNSSIGYLIEEPKLIASMSGLEHLIYFSRIYGNKFDINEFKDLLVS
                     LNLYQILNKKVREYSLGMKQKLAVVISILNYPDYVVLDEPTNGMDVESSYEMLNALKKL
                     AIKTDLGILISSHKLEDIEIICDRILFLENGVLIGEETINQSSQNIIKIIFSNNDDLTM
                     FINKQELGNIYNVTQDTLTLQTSLNSSDVFTLLEELNIFIIDCHTEKNTLRNIYLDKFG
                     GEKNEV"
     gene            21061..21615
                     /locus_tag="FN738_RS03780"
     CDS             21061..21615
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FN738_RS03780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="ABC transporter permease"
                     /protein_id="WP_197736185.1"
                     /transl_table=11
                     /translation="MLGITAMVLQSTYLINNDFSYKTISLIYNSKENRLGYIIGNILIS
                     IFVGAIFSAIGIILFIISKYLGVPGELEIIFLLGFILDVILVIVIYFLCGYCLFLSGFR
                     SGAVYGILILFLLFIPNLLSNIVYGYSNPFLSAVVENFPGYYLPITVGSNVFTLLQYII
                     SLITIFVLFTVVLKKSLRVEV"
     misc_feature    22730..22748
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 25.25"
                     /tool="antismash"
     gene            22855..23226
                     /locus_tag="FN738_RS03785"
     CDS             22855..23226
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002408082.1"
                     /locus_tag="FN738_RS03785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF771 domain-containing protein"
                     /protein_id="WP_061101034.1"
                     /transl_table=11
                     /translation="MKEVKKLEQVIEYSAQIILPKNFILIQREEYNHLKKAGFKGNCIS
                     VEAFRKKHTCLSRPMFNERILLNPRFKKILDIRENPNGCISYPKGGSAGKYYILESKML
                     TFIEEYFSEIFTGLQIDAI"
     gene            23277..24425
                     /locus_tag="FN738_RS03790"
     CDS             23277..24425
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1077: phage integrase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002408083.1"
                     /locus_tag="FN738_RS03790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="site-specific integrase"
                     /protein_id="WP_142963514.1"
                     /transl_table=11
                     /translation="MGISKRGTKWRAFISVKKEGGKYRNKPLGSFDTKFEAVKAVEYAQ
                     SVASKDRRMAFAVPFYEYFEWFFQKYKKEACSKKTQGHYQHTKKYIKKYLGDTPLSDLT
                     NDKYVELLNQFSKDYSPATLEKFHTHMRACVKQAFALGHIPIEFTSGSSLRGRGDKSKE
                     KPIYQKYIDDTQYKKVLQYVVQHRDKESSIYYVIIFSLLTGCRFSEIVGITIDDLNFEQ
                     GFVDINKTYDYMNPPSNLSDWLPCKNKNSYRKVEMPQNLAELLKEFWQYQQEKCQFHQI
                     KNPRKQIFFDWQEGSCDNRKANIEIKKILVTCGITDKPKFSMHCCRHTFVSFLIYQGYS
                     VEEVALIVGDKPEEIRKTYYHVFQEYEVRTRSKTRKLMNSLF"
     gene            complement(24597..24848)
                     /locus_tag="FN738_RS03795"
     CDS             complement(24597..24848)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016633655.1"
                     /locus_tag="FN738_RS03795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_142963515.1"
                     /transl_table=11
                     /translation="MTTMLAIIGTVVIITVQVIEYNMTEIHIPTAGTFNDDDAEPPHSS
                     VTLVFIRTILITLSLNFPSHFFEMVFLCIRENNNKKDC"
     regulatory      complement(24913..25080)
                     /bound_moiety="magnesium"
                     /db_xref="RFAM:RF00380"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00380"
                     /inference="COORDINATES: profile:INFERNAL:1.1.4"
                     /note="The M-box (ykoK) riboswitch appears to function as a
                     genetic 'off' switch that is important for maintaining
                     magnesium homeostasis in bacteria; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    complement(25051..25069)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 21.87"
                     /tool="antismash"
     gene            complement(25143..25922)
                     /locus_tag="FN738_RS03800"
     CDS             complement(25143..25922)
                     /EC_number="7.6.2.7"
                     /GO_function="GO:0005215 - transporter activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002360638.1"
                     /locus_tag="FN738_RS03800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_002360638.1"
                     /transl_table=11
                     /translation="MENKELLSIKSVYKEFEIEGHSEHLKVLENIDLTVKTNEFLSIIG
                     QSGTGKSTLLRSIAGLLRTTRGEITFEDKIINEPDANIGMVFQHFALFPWLTVEKNISF
                     GLENRKEISREQINKRVSNLIEMIGLTGFEKAYPRELSGGMKQRVGFARALAIEPSLLL
                     LDEPFSALDIITASQLSNDLLEIWLNNQIATKSIVMITHDVQQAVQLSDRVVLMDANPG
                     RIAKIYSIDIPRNQRSPKTTIDIVEQITEEMVRRIHL"
     gene            complement(26011..27783)
                     /locus_tag="FN738_RS03805"
     CDS             complement(26011..27783)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016630917.1"
                     /locus_tag="FN738_RS03805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease subunit"
                     /protein_id="WP_002384764.1"
                     /transl_table=11
                     /translation="MEVFKLKAVTASSKKNTLLAKSIGNLTLLIILGIFIFIIVFSWLK
                     MNRPLHTLPSEEFLATPSKTDDFLSPSNLFYFSIRTMFRMIVGMAWSFLFSFVFGILAV
                     KYKTARRVILPLVNFLESVPLLGFLTFTTAWLLGLFPGNVMGAEAVAIFAIFTGQAWNI
                     MLTLYQIMEVIPSDLVNVTDQFKYNAWEKFWRLEFVYSIPGLLWNVIISQTAAWFALVA
                     SEQASVAFPKETNLYLPGIGSYIQVALNRADFKSCLWAVFALLINVVILNFLVFQPLVR
                     ATYYFKYETDVESTTPPKSIIYHLLKKATLTKYFSKAFVKFSHFWIYDLPKVWYFFKLD
                     YLYRLLAKLRHFFKTLWYVSLTIIGVYCSIKLYHFLPHQDFSMIPRLTLYTTLRVTLAM
                     VVAGIIFTPLAIWVANDNRRLSIVQPIGQILGSIPSNVYTPFIVLIISMGFNKLEWWIL
                     PLIMVGCQWYFFFNVIAGYLAIPDDIRDVTKLFKLSKWQWWTKFLIPSILPYLITAIIN
                     AAGAAWNADIAAESIQWGKKSIDVTGLGQYIAANDGVKDKSALGTLAMCFVVGLCIAFV
                     WQPLYRAAKQKFHY"
ORIGIN
        1 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
       61 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      121 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      181 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      241 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      301 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      361 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      421 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      481 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      541 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      601 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      661 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      721 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      781 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnggtgaggt aacctttttg
      841 gagccagccg cctaaggtgg gatagatgat tggggtgaag tcgtaacaag gtagccgtat
      901 cggaaggtgc ggctggatca cctcctttct aaggaatatt acggaaatac acatttcgtc
      961 tttactttgt tcagttttga gaggtctact ctcaatcaaa taaattcggg gccttagctc
     1021 agctgggaga gcgcctgctt tgcacgcagg aggtcagcgg ttcgatcccg ctaggctcca
     1081 ttgatagctt ttgctatcag attcgttcat tgaaaactgg atattgaagt aaaaagaatc
     1141 aaaacaaacc gagaacaccg cgttgaatga gttttttaat aagttcaatt gcttatttat
     1201 tgattaacct tctatcgcta gaagaagtga tcaagaccca accgtaaggt tgataaggtt
     1261 aagtgaannn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1321 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1381 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1441 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1501 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1561 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1621 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1681 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1741 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1801 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1861 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1921 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1981 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2041 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2101 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2161 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2221 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2281 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2341 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2401 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2461 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2521 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2581 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2641 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2701 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2761 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2821 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2881 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2941 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3001 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3061 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3121 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3181 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3241 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3301 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3361 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3421 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3481 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3541 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3601 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3661 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3721 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3781 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3841 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3901 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3961 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4021 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4081 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4141 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4201 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4261 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4321 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4381 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4441 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4501 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4561 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4621 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4681 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4741 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4801 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4861 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4921 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4981 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5041 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5101 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5161 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5221 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5281 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5341 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5401 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5461 nnnnnnnnnn nnnnnnnnnn nnnnnnnnat tcaactcaat aagaaacaac acccagtgtg
     5521 gtggcgatag cgagaaggat acacctgttc ccatgccgaa cacagaagtt aagcttctta
     5581 gcgccgattg tagtgaaggg tttccctttg tgagagtagg acgtcgccgc gcgattattc
     5641 cggcatagct cagttggtag tagcgcatga ctgttaatca tgatgtcgta ggttcgagtc
     5701 ctactgccgg agtttaacat atgaaatatc atgagtatgt gcttctttca gctatggaga
     5761 gttgtccgag aggccgaagg agcatgattg gaaatcatgt aggcggtaaa cactgtctca
     5821 agggttcgaa tcccttactc tccgtttcat atttacaaac tggcccgttg gtcaagcggt
     5881 taagacaccg ccctttcacg gcggtaacac gggttcgagt cccgtacggg tcatttattt
     5941 taatagtaac attccttttt ggaggtttag ctcagctggg agagcacctg ccttacaagc
     6001 agggggtcag cggttcgatc ccgttaacct ccattactcg gttggttccg tggtgtaggg
     6061 gttaacatgc ctgcctgtca cgcaggagat cgcgggttca aatcccgtcg gaaccgccat
     6121 ttaatgttgt tacttgaaaa ttatttgaac aagcttttgt tttaggcgtg gtagctcagt
     6181 tggtagagca acggattgaa gctccgtgtg tcggcagttc gactctgtct cacgccattt
     6241 atggaggaat agcgaagtgg ctaaacgcga cggactgtaa atccgttcct tagggttcag
     6301 tggttcgaat ccactttcct ccattttagg ggcatagttt aaaggtagaa caacggtctc
     6361 caaaaccgtt ggtgtgggtt caattcctgc tgcccctgcc atttaattat ttaatagata
     6421 cactttttaa gattacggcg atcgtggtga agtggttaac acaccagatt gtggctctgg
     6481 cattcgtggg ttcgattccc atcggtcgcc ctttgtaatt ttattggggt atagccaagc
     6541 ggtaaggcaa cggactttga ctccgtcatg cgttggttcg aatccagcta ccccagtttt
     6601 tttgtaacaa aaatggaata tggcggtata gccaagtggt aaggcagagg tctgcaaaac
     6661 cttcatcacc ggttcaaatc cggttaccgc cttccaaaat atcttgccgg cgtggcggaa
     6721 ttggcagacg cgctggactc aaaatccagt tccttcacgg gagtgccggt tcgaccccgg
     6781 ccgccggtat actaaagact gttaaatcaa tgatttaaca gtcttttttc gttatagtgg
     6841 tgcgaaaatg gtgcgaatga aattttttat agtttttctt gtaaaaaaag tagttattta
     6901 attagataaa gggctttaaa tagttattga atatggtcac tattatttta ctagaaaata
     6961 taaaataact tagttaaaag taatatacaa atgaagattt aaatgtatca atatataatc
     7021 aaataagaaa ttaagacgtt caaaatttga gcgtcttttt ttatattcaa catccgagag
     7081 gaggaaaaag gtgagaagac caagaataaa gaatagtaaa ttgctagcgg ctttagtatt
     7141 gctattccaa actgtaaata caggtataac accacttatc gctcatgcag aagaaagaaa
     7201 ttatcctgaa gaagtaacaa ttgagtatga tgctaataat atttacaatg tttcgggggt
     7261 atataataat ggaaaagttt ttaatacgca tacagcccct acctatgcta attataaagg
     7321 gaagaagcaa cctgttttct gcattgagcc agaagtgaat attattaatc cagtcaatcc
     7381 aggttatgaa aaaaatcctt tacctgatat gcctgatcgc gcaaaattag tttccatttt
     7441 atggaaaaaa gttggtcaag atcctgatac ccaagccgtt gcacaaaaaa ttatttggca
     7501 agcagccaat ggctatacca tccataccat gtctcgccca gatggcagta cagtagatat
     7561 tccaagcatt gaagcaaaaa tcaataaagt tgtccaagac tatcaaaaga aacccagctt
     7621 tgatggaacg acaaccaaac tgaacttagg aaagtcgact gttttaacag atacgaatca
     7681 attaaacttg tccgaatttg ataaagtggt cgaaaatact gcgaacattg actatcatgt
     7741 aaacgggaac caattaactt tgagtacgaa tgaacagtca aaatcgggtg tactcacact
     7801 agaaaagtca gaaggaaaag gcacgccagt tgcttataaa aaagctggtg tacaaaccgt
     7861 gatggcaggt gccattgata aaccaacgac ttatacagtc aaactggaca tagaaacaaa
     7921 aggcaaacta aaaattacaa aaatagataa agagtcaggt aaaaaattgc caggaaccgt
     7981 ctttcattta gatttcggtg gaaagtttcc tacacaagaa gtgacaacag gggatgatgg
     8041 aaccagccta attgaaggga ttcctcataa cacaaaagtg actattactg aaaaatctgt
     8101 tccagcgccg tatacgattg acccaacgcc gctttctgcc accatcaaag caggtgaaac
     8161 gattgaaaaa gtatctaaga accttcgaga aaaaggacag atagttttag ataaaaaagg
     8221 tgttgaaaca ggaaccaccc tttggaacga acattactca ttagcgggta atcagtttga
     8281 gatacgtaaa gagacctcag atggaccgat tgttcaaacg ataattacgg atgcaaaagg
     8341 acatgcagaa acgtcaaaag atgttttgaa agcattagaa ttaggaactt attatgtaac
     8401 tgagagcaaa gctagtgctg ggtttgtaaa tacgtttaaa ccagtcaaag tggtcttagc
     8461 ttatcaaaat caaaccgtgc ctatttcagt agaatatgta aaagggacca accaagaaat
     8521 tacaggacaa accactttaa ccaaagaaga caaagataca ggagcggaca cgcaaggaaa
     8581 tgctacgttt aaaggggcac aatatacttt attctatgga gaaaccaatc aaaatcatgc
     8641 taaagataca cctgtaaaat ggcaagatga aagtcatcca gaagttataa aaggtaagaa
     8701 agcttctgaa caagaagtaa cgttaaccat tgataaagaa aatcaagtgg gggtgaaaca
     8761 cttagccatt tccaactact attggaaaga aaccaaggca ccttctttgt aattataaaa
     8821 taattttatt gttagactag aattcgtaag cgtaaagcct aaaattaaaa gaaacctgct
     8881 aataaaagtc aatgaaaaaa gtattagctt attgggagct acatcattag cttcaacaac
     8941 attactagga ggaagtgtat ttgtagtaag tgatacagta aatcctgctc cagcaacagc
     9001 agctacatct gttaaagaag atagatctga cgattaatca aattccatca aatcctaaga
     9061 gatgaaaagc taaaatattg ttgtaacgta gaaaactatg tataactcag ttttctgttt
     9121 taaaataaaa taagaataaa agaaaacaca attctaagag gattgtgttc ttttagggtg
     9181 gaataaatgt taaataggga attctggcaa taaattagct tggatattgc taaaattata
     9241 attactaaca tacaaataac attacgaaat atcaaggtga acagagttta agcataaaaa
     9301 gatagtcata ctttttattt tgattattct gtaaatggca aatgatcttt attgacacaa
     9361 caggtatttt ttatttcttg acgatagata cgaatcagct tcttcataaa ttttagtaaa
     9421 ttgatttacc agtttggagc tgattgtttc tataaaataa agttacaaaa ggaaaagtta
     9481 cgtgtctgaa acgtctatta acattgaatt ttatacgttt tcatgtgacg aataatgaca
     9541 ttctaaggag gtgaactata tgcgtgatga agaaaacaac gaaactttga tcaataatga
     9601 acaagttgct tggttcgaag aagtagccga tcaatcattc gacgatgacg ttttcggtgc
     9661 ctgcactact aatacatttt cattaagtga ttattgggga aacaaaggaa attggtgtac
     9721 agctacacac gaatgtatgg gttggtgtaa ataattttat aaaaaggagc ttttataatg
     9781 aataatgaca aacaaaatga acaaaatgtg gatttagagt tgggtaaata cctagaggca
     9841 gatttaattt ctttaacaga cgatgaagtt acaggaggag gaacacccac aattactatt
     9901 cctatttcta tcgctgtttc aggttggatt tcagataaaa catgtccaac aagcgtttgt
     9961 acgagggctt gttaataaaa tgaatgtgag gtgtgaatga atggttgtct acagcaaaaa
    10021 agtttatccc gaattagagt taaaagatta taatgagcat attttaccca tagttcatta
    10081 tattgaacaa ttaaatttaa aaaaattaat tgaactgcca actatagtaa attataaaac
    10141 agaggaaaaa tatccatact ataatgtatg tatgtccatt actagcgaaa tttgggataa
    10201 agtttggaat aacaaattag acgcctatgt tcacaatcca ttatctttca aagaagctat
    10261 ttgcgatgat ttatcgcaag tagctttctc ttatatgata cgaggatttt ctgaacatat
    10321 aaaattatta caaaatgtcg aattagaaaa ttcgtattta ctttataatg aaacactaaa
    10381 aagaaataag atgaaagaat tttctgagac gtattttgtt acttggaata gatgtattaa
    10441 cttaataata agtagaataa actctattgt agatactgtc aaaagaatac agcaatacag
    10501 aatagatatt gagaaaaaat ttaatattaa tagagactta aaaatagtgt atgtgaagtc
    10561 tgatggtgat acgcataatg acggatcatc agtgtcaatt atttattttg aagacaaaca
    10621 aaaaattatc tataaaccac gttctgtttc tggagaagcc ggatacacca aattaattat
    10681 ggctatcaat tataaattta atttgaatct acctgtgtta tctgtgatta attgtggaaa
    10741 ttacggtttt acctcatttg aaactagtga cgaaactcag gttgatatgt ataaagctgg
    10801 ccaactcgca tgcttaatgt acttattgaa tgcgtccgat atgcattata gtaatatatt
    10861 atggacacat aaaggaccgt tgccaataga tctcgaaacg ttattccacc cgtctcgcaa
    10921 tagatccggt ataccagaat ctagcaatag tgcctatgac tctttagaaa agtctgttta
    10981 tggtactgga gtactaccaa tttctattag cgataaaaac aaaagtggtt cagttgacgt
    11041 tggtttcacg ggaattagag ataaaaacag tgttagtcct tttaaaacct ttgaattaat
    11101 caacggattt aattctaaca ttaaagttgt atggcataac tcagccactg tttctgaaga
    11161 tcttataaat gactcggaat atgaaaaaca gatttatgaa aactgtgcta aagttgtcga
    11221 tggttttact gatgtctact tattaatact aaaaaacaaa gaatttttta gtaaagaagt
    11281 aataacatct tttaaaggtg ctaaacttcg ttatatccac aatatgactt atagatatga
    11341 gcaaatatta cgagttttaa cagcaacaga accttcgaaa gatttagata tggcacattc
    11401 actattatct agaattggta ttttaagtat gactagtgat aaaaatatta ctaaatccga
    11461 atgtagtcaa ttgtggaagg gagatattcc ttactttaca ataaattttg atggtacaga
    11521 aattcatagt aataatgata ttgtatccac agttaaaaat agcccccaat ccgaatttat
    11581 tcgtaagatg aaaaaactat cacaaaaaga tttaattaat cagcaacaaa ttatacaact
    11641 agcatttgtt gctaaattag cagacccaca cgcggaagga aaattaaaac tagaagagtt
    11701 agagaatggg aatcaaaaag ctatagagaa aaaaagtgat ggactaaaaa agactacaga
    11761 gataattaaa actattaaat ggttttctca aaatttatta aattcagtac ttgatgatcg
    11821 atatgaacat ttgccaaaaa cttgggtagg tgcagtagct aaaaacggga ataatggatg
    11881 gacacctgga gttttaggat acgatttata tagtggcaga ataggtcctg cactagtgct
    11941 atctattgta ggtaatcagt tttctgatat tgaggctaca aatatttcca acgatatatt
    12001 tgaaaaatct gctcaaatcc tcgaaaatca aagttttgaa ttaaggaatg tgttgttgtc
    12061 aggtactgga gctttttcag gtatctctgg gttactttgg gcaatgtatc atgcaggtac
    12121 cattacaaat aaccaacgat ggaaaaacgt cgctattaat tcttgggaac ttttaagaat
    12181 ggacttagaa actgttgaca ataatttttt tgatatgatt aatggaaaaa gtggtgcgat
    12241 tataatgcgc ttacagatgc aagacacttt ccatccaaaa caagaatttt tagataagtg
    12301 tgttaattta gcttatgaaa aaattaacga aattgatagt tatatgactt ctggagttgc
    12361 acacggatta ggacatttac tttggttttt ttctataatt aatcaaagaa taaaagataa
    12421 taaaataaaa aaattaatta tagatataga tactgctatc aagaagaatt acacaaataa
    12481 agaaggtgtc atcgaaactt acttaactga acagaatgag catgtgtcct cttcatggtg
    12541 taatgggttg tcaggcttac taattgctta ctatgaggcc tataaagcgg atgcattacc
    12601 aaaagtatca gtaatatctg ttataaatca attgaaaacc ataccgatct catgcgttcc
    12661 tgtcctttgc catgggagtt tgggtgttct cactgcttta gaatatgtcc acgaatcttt
    12721 tccagaagaa acaaaaatac tgattcataa tataaaaaat acattttgtt ccccaacata
    12781 tatctatgaa tattttaaag aagggaaagg tcgatataca ctaagtccag gcttaatgtc
    12841 aggaaaagca ggggcattgt tacacttatg taaactagca aatagtgatt tgaaaatatc
    12901 acctttattg ttaggtgtat aaaatgaaaa attttatttt taaaaataaa agaaaattaa
    12961 aacctactat tcaggtagcc caaacggaat gtggcttatg ttgtgttcga actattttag
    13021 aagcttatgg atgtcataaa aaacttacgg accttagaca aataaaagaa cctggaagag
    13081 atggactcgg cttaactcaa ttaaaagaat tgttaatgca catggggatg gatgttcaaa
    13141 cttataaaat caaagacttg agagcttttg aagttgtaga ttttccgata attgcttttt
    13201 ggaaaggata tcactttgtg tgcatagaat tattcagcga aaaatatgtt atcattatgg
    13261 atccgtcaat aggaagaata aaaatatcaa ttaatgaatt tcaaaaagat ttttctcagt
    13321 atatcttagt agctaaaccc aataaaaact ttgtaaaagt taaaaaaaat aaattagata
    13381 cttggaaaaa agactacatt tggccgaata atatgatgag tctctatcta ggtttgctaa
    13441 tgactagtat tattttagta attatgactt tatctattcc tatatttaca caatcgttga
    13501 tagataagag tagttactta aattctatat cgtttgtaaa aacaatagaa ttactactat
    13561 tagcaataat tacgatgatt ggtctaaaca ccttcagaag ttacctttca attaaaatta
    13621 gttacaaatt caattggcat ttattagttg gagctttcgc acatacctta tcattacccg
    13681 ctaaattttt tacagtacga tctccaggag aagttatttt taggttaaat tcattgacta
    13741 gaattcaaga tgttttagga attactttgg tacaaacttt tctggacata gttagtagta
    13801 ttgtaatact tggatatatt ttttggagtt cttggacttt ggggattatt atcgtcacat
    13861 taataatgtt tatgttttta tttttgatta taactcaaaa atatgtagac tctgcaacag
    13921 ataaagaatt gcgtgaagga tctagtgttc agagtatcca attagatgct ctagcttcta
    13981 taaatagtgt aaaactaggg ggctatgtac agtcgtattt ttctgattgg aaagataagc
    14041 ttacaaaact tttatctgct tcttcacata ggatgtatct tcaacaaggt attgttggat
    14101 ccgttttata tggaatgcaa actatttttc ctttaattat tcttgttatt agtctatatc
    14161 aggaaaaatt agggacatta tcattaggtc aagtaatagc tattcaatcg actgttagta
    14221 tgttatttaa ttattcaaat acaatattta gtaccctttc aaacattatg gtggtagaac
    14281 gatatattga gttatctgag gatatatttg actatcctat tgaatcaagt gttagaagtg
    14341 atcatattat ggagtctgga aatctttcga taaataattt gtattttcaa tatacttctg
    14401 atacaaaacc agcgttgaaa aatattaatt taaaaatatt ggatggagaa acagttgctt
    14461 ttgtaggtgt atccggatcc ggaaaaacaa cactagccaa aatatgtagt agtttatttg
    14521 aacctactaa aggagatata tttttttcag atattaattt tcaacgatat aaccttgatc
    14581 aattaagaaa atcaattagt tatattcctc aagaggctca tttgcataat cgcacaataa
    14641 tagaaaattt gaaattagga agtcaattaa gtgaagaaaa aataattgaa ttatgtagtt
    14701 ctttagaatt tttatctttt atttctgatc taccaatggg atacaatact gtaatttctg
    14761 aaatgggagc aaatttatct ggtggacaaa gacaaagaat tcatatcgca cgagcaattc
    14821 ttcaaaatcc taaaatacta atcatggatg aggctacatc atcattagat aatatttctc
    14881 aaagttctgt atatacagaa ctatctaaac tagagtgtac aaaaatagta attgcccatc
    14941 gtctagaaac gattctaaat gctgataaaa tatttgttct tagagacgga gaaattgtgc
    15001 aaacaggtca ccataatgat ctagtccaac aacctggaga ctataaggat ttatttaata
    15061 cggtaattga aaaggagaaa taactgtgca caatgataat aaattagtta atattataga
    15121 agatatcttt aaagatatag ttgaacacac acacactacc ttaaaaagat cttttacaac
    15181 atttcaagaa aaagaaacag aagtttttat aaagtgtttt catgctttaa tagaatatca
    15241 tataaataga gtcgttcaga aaacatttat ttacgaattc catgaatttc gaaagagttt
    15301 aaatatgcct gctaatccaa attcttccgt tgcatttgat ctgtttttac agaaactgga
    15361 taaacaaatg gttgaaaaat ggctaaacaa atacagctat ttaagaacaa ttattcatac
    15421 aattataaat aatacaagct tatacattat agcagtatgc aaaaatttca aggaagatat
    15481 agatcaatta aataataatg agatgattag taaaaattct tatttaactg ctataaatgc
    15541 attagattct gatccgcaca atggttcaaa aatcgtttta tgttttgaat tttcaaatga
    15601 agaaaaaatt ttatataaac cccgttctct agaaatagac caattaatag acacgatatt
    15661 ttctgatatt ctaaagttta aagggctcaa atataataca ccaattgctc aaacaatatg
    15721 tcgaaatagc tatggttggc aaaaatttat ttctcatact tttattgatg aggcagactt
    15781 atcagaagct tattataatt tggggctgtg tgcagcagta ttcagaagta ttggtgccac
    15841 cgatttacat gatgaaaatg tgatttttaa cggaactact ccttatttca ttgatttaga
    15901 aactagttta aaaccatcac acgaagaaat aaatgaggat tctatatggg acgtattaaa
    15961 taaagaactc tctaattcta ttgctaatac ttgtataatt ccagctaagt taatggtagc
    16021 accacataat atcttaattg gggctattaa tacaccttat ccacaaaaaa cagaagaatt
    16081 atgtttcact ctgaccaatc caggaactga tgcagtagat atatctaaac aaaatattat
    16141 agtttctaga gattcagctc ctataatgtt agaaaaaaat aaatttccta gccctcttcc
    16201 ataccagcaa gactttgtta acggctatga agaaggtatt aaatctgtaa tagtaaatcg
    16261 tgaaaagatt agtgatttat taagtagttt tccttgcacc agtagaataa ttgtgagacc
    16321 aactgttcaa tattttttct tactggatgc atgtttgtat cccgaaaatt taattgatga
    16381 gtctgctata gataaaatat tatcttatat gaagccttct aaaatgttta cagaatcgga
    16441 aaatgcaagt aaagtacttg aggcagaaaa aaaagcttta aaaaaaggag atattccgta
    16501 tttttcaatt gggtcgaata agcatacaat taatttaatg aacataaata ccaatacatt
    16561 tgaaatgtct ccaatagaaa atgctttata ttctttaaat aatctttctg atcgggcact
    16621 tttaattgat aaacgtttaa ttgcagaggg gttttctgaa attaggattc atgaagcaac
    16681 atttgaaaat aataaaacta aaaaatcaca agctaaaatg ttcactgatg ttttaaaaga
    16741 agtgacaata gacaacccag atgcattatt taagttaata ataaatcaat ctattactac
    16801 aaaatctaaa aatgctgaaa caggttggtt aaacggggtt tatggagaca tgaatattgc
    16861 ttacaattct atatcatgta tttcgttgca tgatgctggt ggtattttat ttctacttaa
    16921 acatttaaca gaatataaaa aatgcgttga tgatatagaa acaaatgaat tatatattcg
    16981 tgcttctaaa ggtgtcaact ctcttaaaaa tactatttat ggttctacag aagtttcaaa
    17041 taccccaatg tcaattattt caggatcaaa ttctcttgaa tttctgttta actatgaaca
    17101 aaaaaaactg aaatatcttg ataagactat atcaaaaatt caattagaga atattgaaag
    17161 tggagatgtt tttttaggtc caataggtat tgcattagta aatgctactt ttcctaatac
    17221 gtctatcgat aatatcattt attttacaga aaaattccat aataccaaat tacctagtga
    17281 aggaatagct cacggaaatc taggtgtttt atggacaaat ttcagattaa attatgcctt
    17341 ggacagatta gatatatgta aaaatatatt tcatgaaacg actcggatta agtttgagga
    17401 atctgttgaa aatgttggat ggtgcaacgg aaattcgggt ctattaatgg tactgacaga
    17461 aatggctact ctattaaaag ttgacataaa tttatttgat ttggccaaaa aatctactat
    17521 tcttccatta gaaactcctt tagatttatc aatctgtcat ggagtatcag gtgttcttca
    17581 atcactgctt ttttccttta aagtttcaaa aaaatctgag tatataatgc tagctaacga
    17641 gtattggtta tccgtcctta aactaataga cataaatggt tactatacag gtgaaaaaaa
    17701 cagggattat ttacttggat attttttagg ctggagtggt atggctgatt cagcattatt
    17761 attaaaaatg tacaatgaag ggtcctctcc tttgattcct ctaaatttga gttccttaga
    17821 ttatcagaaa aagctgatgg aggtgtaaac tatgaaagcc ctagttgcaa taaatcccag
    17881 atacaaaaat tcattagagt ttaaaaaaat ggaaacagtt aaattcggat ctactaatgt
    17941 tctatttgga ttagtagagt taaatcaacc cgattttgat ataaataatc ttcaaaatga
    18001 tgattatata ttaataaaag ttaaatattt ttcttgtaac tatagagata aatctatctt
    18061 attagaagcc tatatttctg aaaaaaacga aaatagatta ttctttccat ttggttcaga
    18121 atttagtgct gaaattatta agattggaaa aaatgttaat aatttcaatg ttggagattt
    18181 tgtcatgcca aactgcgaat atcctcatgg agtaaaacca ggaataccga gtaattttgc
    18241 atctttagga tggttaaaaa ttcacaaaag taaagttatt aaaattccag cacgtctaag
    18301 tcttgaagaa gctgcatgtt tttctttagg ctcacaaact gcttccagta tgattagacg
    18361 atctaatatt ttgaaagaaa gtggtaatcc agtagttttc agcgcacgct ctgcaacttc
    18421 tatgtttatt attcgtcaac tacttataca aggaattaca cctatatgta tatctactac
    18481 ttcatggaca gattttgaaa aagaatatat atatccttgt gaggtggaac gtttagaaga
    18541 cgtatctttg caagctatga agcgaaatat tacgcacgtt tttgatcctt tttttgatct
    18601 taatgtagaa aatgcagtaa atttattaca aattggaggc acttatataa cttgtgggct
    18661 tttaaatcaa caccctcttt tatctgagaa aatacctata gaaaatgagc caattttaag
    18721 aagagcacta agtatgggag taatgaaaaa tattacattt ataggaaact gcttaggaac
    18781 atatgaagat ttgcaaaatg ctatcagttt agaggaaaga ttctctgtga aacctgtaat
    18841 tgataaatct tataacgtta accaatacct agattttata aatcgttcat tttttaacgc
    18901 taataaaata ggtaaggtgt ctttaaccta ccattaatta cagtgtacta aaaatttaaa
    18961 attattcaga tttttagtac atttaacttt acttttgtta aactttactt taatatttga
    19021 gtagagatgt gaaaaaattg ttaaatttgg ttcaaaagct aggggttttc tctttttcaa
    19081 cacgaaaaaa gatttttgaa tcataactat ataaaagtaa ggaaagctat gaaaatactc
    19141 ggtagttact tgaataactt caaataattc gtttaagtgc ttttaatttt agttaggact
    19201 gttttttgga taaataatta atctttacga tattctctac atcgttttat cagttaaaag
    19261 aactggtccc tagtgattat ctttgtctga atactagtat attacttttg taaatttaga
    19321 taacaaagga aaaattttcc cctgaactgc ttatgaatac taagtttaaa cgtttttcac
    19381 acggttaatt aactataagt agggtgacta tatgaagaaa aaaatacacg aagaatctat
    19441 acgtaataaa gtttacgaat atagagtttt agccagacta tcacaacaag aattagctga
    19501 tagagttggt gtatctaaac aaacaatttt tgttatggaa aagggaaact atgtaccgtc
    19561 gttactatta gcatttcgaa tatcaaattt ttttaatgta ccgcttacag agatttttga
    19621 atacgattta ggaggacaaa ataatgatga ataaatctat tggattttca tttaacgcct
    19681 taaatgaatg gtcagaaaaa agtattggga attataattt acttattggt gttggttttt
    19741 tacttgtaat gattagttct attactttag tatatctgtt attaaagttg ggacaaagag
    19801 atgagcgcac aacaaaaatt catttaaatg tatgttgcta tatgttggta accattgttt
    19861 tgtgtgactt attctttcct aaagaataca tgcaaaatat actattctta ttcaaatatg
    19921 cactagcatt ttctatatct ttaatttact tacttaaaaa atataaacaa gatttatgtt
    19981 aattacttat aaaaatcata ggatgaatat gctgactagc agttaggaga aagaatatga
    20041 atattaataa agtatctaaa tcttataata atacaagtgt attagataat atatctttca
    20101 attttaaaaa aggtgaaata ataggattag ttggtagaaa tggtgcaggg aaaagtacgt
    20161 taatgaagat tattactgaa aatatcctta actttaatgg atctattatg agaaatagct
    20221 cgataggata tttaattgaa gagccaaaac taatagcaag tatgtctggg ttagaacatt
    20281 taatatattt ttctagaatt tatgggaata aatttgatat aaacgaattc aaagatttat
    20341 tagtaagtct aaatttatat caaatattga ataaaaaggt tagagaatat tctttgggaa
    20401 tgaagcaaaa attagcagtg gttatttcta tcttaaatta tccagattat gttgtactag
    20461 atgagcccac taatggaatg gatgttgaat catcatatga aatgttgaac gctctgaaaa
    20521 aacttgctat taaaacggat ttaggtatat taatttccag ccacaaatta gaagatatag
    20581 aaataatctg tgataggatt ctatttttag aaaatggtgt tcttattgga gaagaaacaa
    20641 ttaatcagag ttcgcaaaac ataataaaaa ttatcttttc caacaatgat gatttaacta
    20701 tgtttatcaa taagcaagaa ttagggaata tttataatgt aactcaagat acgttgacat
    20761 tacagacaag cttaaatagt agtgacgttt ttactttatt agaagagtta aatatattta
    20821 taattgattg tcatactgaa aaaaatactc ttcgtaatat ttatttagat aaatttggtg
    20881 gtgaaaaaaa tgaagtttaa tataacaggg tacgtctcgt ataatctaaa aagactaata
    20941 acgcgtggct atttaccact aggattgatg ataagtatac tcccagcatc tattatgtgt
    21001 tacattattt tagttaattc tgcaccattt acaattaaac atatttcgaa tttctattgt
    21061 atgttaggga taacagcaat ggttctccag tctacgtatt taataaataa tgacttttct
    21121 tacaaaacta ttagtttgat atataattca aaagaaaata gactaggtta tattattggt
    21181 aacatactta tttctatatt tgtaggcgca atattttctg ctattggaat aattttattt
    21241 atcatatcta aatacttagg tgtaccagga gaattagaga taatattttt attaggattc
    21301 atacttgacg taattctagt catagtaatc tattttttat gtggatactg tttattttta
    21361 tcgggatttc gtagtggtgc agtgtatggt atattaatac ttttcttgct ttttatccct
    21421 aatttgcttt ctaatatagt ttatggatat tcaaatcctt ttttatcagc ggtagtagaa
    21481 aattttcctg gctactattt gccgattacc gtaggatcga atgtatttac actattacaa
    21541 tatataatta gtttaataac aatatttgta ttatttacag ttgtattaaa aaaaagttta
    21601 cgggtagaag tttgattaag tttactaacg aaagttgtgt ctcatatgga gtataaagat
    21661 atcattaaat ggttaatact tatgtatata tcctctaaat cagcatcata tttttataaa
    21721 atattggact caacaataat taatatatgg atttctagat taatatgttg tgttgttgcc
    21781 ggaatcatag gtatcatttt acacaaatat tggtttacga ttgtttaaat aggattgatt
    21841 ttttaaattt aaggtgacaa aaaccttgaa atataaacgt gtaggaatcc aaaatcatat
    21901 cgtaaatttc tttgattgcg tcccaatatt caattatatt ttaaagttac tagtctttct
    21961 atagtggaat tggtagtttt tcaaaatttt ttactaattg gattgaataa caaggtgatt
    22021 agagttagag gttattatga tttatgaatc aacaaggtat atctcaatgt cattaagtta
    22081 agaaaaatcg tatatacaat agtgtgtaat tgaataaaat taagttgtaa tttaagtgat
    22141 ctttaacaat acccccctct agaagacatg tcttctagag gggggtacaa cttgttctac
    22201 aagaattact tttttatttt taacttgtta tattttagaa cttagtattg ttattttgtt
    22261 ttacttcttt atcaaaatac aaaactggat taaattcttc tttgttaagt tctattattt
    22321 ttacatagga aaagcaggaa agcttaaatg ttttcctgct ttcttaactg aatgacactg
    22381 aggcatacct tgtcggttct ttttcatatt ctgattgttt acaggtaaac agtaggatat
    22441 tcaagttggg catacgtcat ttgtgtcaat tttgagtata ctttttttaa tctatttagt
    22501 gtcttgaaaa agagaatgtt ttggttgtta tagatatgaa acaggaaata accattaaat
    22561 ttcctgcctg tgttctttga caactaaata aaaatctacc agtaccttcc atctacgagg
    22621 agcatgtttt agctacgcca agacaaagaa aaaaaatctt tgagtgaata atttctaaag
    22681 caacttaact gtcaattaag gccaagattc gtaaatgaac taatgatact tccgtgaggc
    22741 tcaccataat gaggggagag gtgaaattcc tatgatgctt ctgacaaaag cagctgatag
    22801 atttaaagag atatttatta atagaaagaa aaataaataa tttaaactaa atggatgaaa
    22861 gaagtgaaaa aattggaaca agtgatagaa tatagtgctc agataatttt accaaaaaat
    22921 ttcattctaa ttcaaagaga ggagtacaat catttaaaaa aagcgggttt taaaggaaac
    22981 tgtatttctg tagaagcgtt taggaaaaaa catacttgtt taagtcgacc aatgtttaat
    23041 gaacgaattc ttttgaatcc gagatttaaa aaaatcttag atataagaga aaatcccaat
    23101 ggttgtatct cgtatccgaa aggtggcagt gctggcaaat attatatatt agaaagtaag
    23161 atgttaacgt ttattgaaga gtatttttca gagattttta ccggtttaca gatagatgcg
    23221 atataattat cttgaccata gctatttaaa agcccttttt aaaagaggcg atttaaatgg
    23281 gaattagtaa acgaggaaca aagtggcgtg cttttataag tgtaaagaag gaaggcggaa
    23341 aatatagaaa taagccgtta ggtagttttg atactaaatt tgaagcagta aaagcagtag
    23401 aatatgcgca atcagtcgct tcaaaagatc gacgtatggc gtttgcggtc cctttttatg
    23461 agtattttga atggtttttt caaaaatata aaaaagaggc ttgttccaaa aaaacgcaag
    23521 gacactatca acacactaaa aaatatatta aaaagtatct aggtgataca ccattatctg
    23581 acttaacaaa tgataagtac gtagaattgt tgaatcagtt ttctaaagac tattcgccag
    23641 ctactttaga aaagtttcat actcatatgc gtgcttgtgt caaacaggct tttgctctgg
    23701 ggcatattcc tattgagttt acttcaggta gttctttgag aggccgtgga gataagtcta
    23761 aagagaaacc aatttatcaa aagtatattg atgatactca gtataaaaaa gttttacagt
    23821 atgttgttca acatagagat aaagaatctt ctatttatta tgtaatcatc ttttctctac
    23881 ttacaggttg ccgtttttct gaaatagttg ggattacaat cgatgattta aactttgaac
    23941 aagggtttgt agatataaac aaaacgtacg attatatgaa tccgccgtct aatttaagcg
    24001 attggcttcc ctgtaaaaat aaaaatagct atcgtaaggt agaaatgcca cagaatttgg
    24061 cagaactatt gaaagagttt tggcaatatc aacaggaaaa atgccagttt catcaaatta
    24121 aaaatccacg taaacaaatt ttttttgatt ggcaagaagg ctcctgtgac aaccgaaagg
    24181 ccaatattga gattaaaaaa attcttgtga catgtggaat aactgataaa ccaaaatttt
    24241 ctatgcattg ttgcagacat acttttgttt cttttttaat ctatcaaggc tattcagtag
    24301 aagaagttgc tttaattgtt ggagataaac cagaagaaat aagaaaaaca tactatcatg
    24361 tctttcagga atatgaagtt agaacacgat ctaaaacccg caaattgatg aattcactct
    24421 tttaatttgt tatttaatac taaattagct ggtgcaaaga tggtgcgaga aaatgaaaaa
    24481 tagttaaaaa tatttaaagt gaaacgttga aatgacagtt tttataaagt atttgacggt
    24541 attttaggta aacaatctct ggccgccggt atactaaaga ctgttaaatc attgatttaa
    24601 cagtcttttt tgttattatt ttctcgaata cataaaaaaa ccatctcaaa aaaatgagat
    24661 ggaaagttaa gtgagagagt gataagtata gtgcgaataa atacaagggt tacagaagaa
    24721 tgtgggggtt ctgcatcatc gtcattaaat gttcctgcag taggaatatg aatttctgtc
    24781 atattatatt caataacttg aactgtgatg attacaacag ttccaatgat tgctaacata
    24841 gtagtcatac tttcactcct ctcttaattt taaataaaag tacttaactg attgactaga
    24901 gactaaaagt atacatcaac atgaacgttg agctttagca ctatacaacg taaagatcac
    24961 tcttagctat tttgagaaaa gccttctcct cgaccagtct tgttctactc attggtgtct
    25021 ctcgacattt ctgagcaata gcctatgttt gtataggagc ctcacctaac ttattacaaa
    25081 gaaataatag tcttttaagt aactctttgt caagacataa gcagaagtca aaacagttct
    25141 atttacaaat gaatgcgacg aaccatttct tctgttattt gttctacaat atcaatggtt
    25201 gtttttggcg aacgttgatt tctggggata tcgattgagt aaattttggc aatacgacca
    25261 ggatttgcat ccattaatac aacccgatca gaaagttgga ctgcttgttg aacgtcatgc
    25321 gtgatcatta caattgattt agtcgcaatt tgattgttta gccaaatttc taataaatcg
    25381 ttagataatt ggctggctgt aatgatatct aaagctgaaa aaggttcgtc taagagcaat
    25441 aagctaggtt cgatggctaa agcacgagca aagcctacac gctgtttcat tccaccagat
    25501 aactctctgg gataagcttt ttcaaaacca gttaaaccaa tcatttcaat gagattactg
    25561 actcttttat ttatttgttc acgggaaatt tctttacggt tttctaagcc aaagctgata
    25621 tttttttcaa ctgtcaacca aggaaaaagg gcaaaatgtt gaaaaaccat gccgatattg
    25681 gcatcaggct cattaatgat tttatcttca aaagtaattt cacctctagt tgtacgaaga
    25741 agtccagcaa tacttctgag caacgttgat tttcctgttc ctgattgtcc gataatactt
    25801 aaaaattcat tcgttttaac tgttaaatca atattttcaa ggacttttaa atgttctgaa
    25861 tgtccttcaa tttcaaattc tttatatact gattttatgc ttaataattc tttattttcc
    25921 atcgtcttat tagataggta aagggaaatc acctatcgtt ctcctctcta gtttatctta
    25981 aaaatttagt cgagttgagt cgtccagcta ttaatagtga aatttttgtt ttgctgctcg
    26041 atataaaggt tgccaaacaa aggcaataca taaaccaaca acgaaacaca tcgctaaggt
    26101 tcctaaggca gatttatctt ttacgccatc atttgccgca atatattgtc ctaggccagt
    26161 aacatctatt gattttttgc cccattgaat gctttctgct gcgatatcag cgttccaagc
    26221 agcaccagca gcgttaataa ttgctgtaat gaggtaaggt aaaatagaag ggatcaaaaa
    26281 ttttgtccac cattgccatt tagataattt aaaaagtttg gttacgtcac gaatatcatc
    26341 agggatggct aagtagccag caattacatt aaagaaaaaa taccattggc aaccaaccat
    26401 gatgagtggt aaaatccacc attctaattt gttgaagccc atactaataa tcaacacaat
    26461 gaatggagta taaacatttg acggaatgga gcctaaaatt tgtccaatcg gttgaacgat
    26521 acttaagcgc cgattatcat tcgcaaccca gattgctaag ggagtaaaga taatgccagc
    26581 aacgaccata gccaaggtaa cccgtagtgt agtataaagg gttaatctag gaatcatgct
    26641 gaaatcttga tggggcaaga aatgatagag cttaatagaa caataaaccc caataatggt
    26701 taagctgaca taccataatg ttttgaagaa atggcgtaat tttgctagta atcgatagag
    26761 atagtctagc ttgaaaaagt accaaacttt tggtaaatcg taaatccaaa aatgactgaa
    26821 tttcacaaaa gcttttgaaa agtatttcgt taaagttgct ttttttaata aatgataaat
    26881 gatggattta ggtggcgtcg tactttcgac atctgtttca tatttaaaat aataagtggc
    26941 tcgaactaaa ggttgaaaaa ctaaaaagtt taaaatcacc acattgatta ataaggcaaa
    27001 aacagcccat aaacaggatt taaagtcggc tcgatttaat gctacttgga tataagaacc
    27061 aattcctggt aaataaaggt tggtttcttt aggaaaggca acagaagctt gctcgctggc
    27121 caccaaggca aaccaagccg cagtttgaga aataataacg ttccaaagta agccaggaat
    27181 tgagtaaaca aattcaagac gccaaaattt ttcccaagca ttgtacttga actgatcggt
    27241 cacattcact agatctgaag gaataacttc cattatttga taaagagtca acatgatgtt
    27301 ccaagcttga cctgtgaaga tggcaaaaat agcaaccgct tctgcgccca tcacatttcc
    27361 tggaaataaa ccaagtaacc aagcagttgt aaaggtcaaa aaacctagca atggaacaga
    27421 ttcaaggaaa ttaactaatg gtaaaatgac tcttcgtgcc gttttatatt ttacggctaa
    27481 aataccaaaa acaaaggaaa acaggaagga ccaagccatg cctacaatca ttcgaaacat
    27541 ggttcgaatt gaaaagtaaa aaagatttga tggagataag aaatcatctg ttttacttgg
    27601 tgttgcgagg aattcttctg agggaagggt gtgaagaggg cgattcattt ttagccaaga
    27661 gaagacgatg ataaaaatga aaatgcctaa aatgatgagc aaggtaagat tcccgatgct
    27721 tttagcaagt agggtatttt tcttagatga tgcagtgaca gctttcaatt taaaaacctc
    27781 caattaatca tattaaagag gtcgccgaat aaaagaagat tatagggtaa tcacaataat
    27841 tgagcttt
//
