GCF_902161995.1 - 5 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CABGTR010000001.1 (Enterococcus faecalis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	lassopeptide	341,169	365,550	Low	cochonodin I	ribosomal:RiPP
Region 1.2	cyclic-lactone-autoinducer	706,956	727,684

NZ_CABGTR010000003.1 (Enterococcus faecalis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 3.1	lanthipeptide-class-ii	110,719	133,703

NZ_CABGTR010000005.1 (Enterococcus faecalis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 5.1	terpene-precursor,cyclic-lactone-autoinducer,azole-containing-RiPP	70,231	110,700

NZ_CABGTR010000006.1 (Enterococcus faecalis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 6.1	RiPP-like	74,109	85,152

No secondary metabolite regions were found in these records:: NZ_CABGTR010000002.1 (Enterococcus faecalis); NZ_CABGTR010000004.1 (Enterococcus faecalis); NZ_CABGTR010000007.1 (Enterococcus faecalis); NZ_CABGTR010000008.1 (Enterococcus faecalis); NZ_CABGTR010000009.1 (Enterococcus faecalis); NZ_CABGTR010000010.1 (Enterococcus faecalis); NZ_CABGTR010000011.1 (Enterococcus faecalis); NZ_CABGTR010000012.1 (Enterococcus faecalis); NZ_CABGTR010000013.1 (Enterococcus faecalis); NZ_CABGTR010000014.1 (Enterococcus faecalis)

Compact view

NZ_CABGTR010000001.1 - Region 1 - lassopeptide

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Location: 341,169 - 365,550 nt. (total: 24,382 nt) Show pHMM detection rules used

lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lasso peptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

FN307_RS01810: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: aminotransferase

FN307_RS01720: aminotransferase class V

smcogs: SMCOG1139: aminotransferase class V

Hydrolases: hydrolase

FN307_RS01770: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002575.2	0.64	ribosomal	cochonodin I	Streptococcus suis
BGC0001634.3	0.56	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0001496.3	0.56	ribosomal	actinokineosin	Actinokineospora spheciospongiae
BGC0002276.2	0.55	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001552.3	0.53	ribosomal	citrulassin F	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001550.3	0.52	ribosomal	citrulassin D	Streptomyces katrae
BGC0001176.4	0.52	ribosomal	streptomonomicin	Streptomonospora alba
BGC0001549.3	0.52	ribosomal	citrulassin B	Streptomyces aurantiacus JA 4570
BGC0000575.5	0.51	ribosomal	lariatin	Rhodococcus jostii
BGC0001889.2	0.50	ribosomal	fusilassin	Thermobifida fusca YX

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002575.2	0.64	ribosomal	cochonodin I	Streptococcus suis
BGC0001634.3	0.56	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0001496.3	0.56	ribosomal	actinokineosin	Actinokineospora spheciospongiae
BGC0002276.2	0.55	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001552.3	0.53	ribosomal	citrulassin F	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001550.3	0.52	ribosomal	citrulassin D	Streptomyces katrae
BGC0001176.4	0.52	ribosomal	streptomonomicin	Streptomonospora alba
BGC0001549.3	0.52	ribosomal	citrulassin B	Streptomyces aurantiacus JA 4570
BGC0000575.5	0.51	ribosomal	lariatin	Rhodococcus jostii
BGC0001889.2	0.50	ribosomal	fusilassin	Thermobifida fusca YX

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lasso peptide predictions

Lassopeptides - No core peptides found.

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.78 out of 20.97

Confidence: strong

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.80 out of 26.33

Confidence: medium

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 28.04 out of 32.74

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.62 out of 24.78

Confidence: medium

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.46 out of 27.04

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.16 out of 26.06

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.91 out of 28.19

Confidence: medium

Additional weak hits (1):

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.37 out of 30.98

Confidence: weak

Lasso peptides

RREFinder

TFBS Finder

Core peptide predictions

No core peptides found.

RRE predictions

: RRE type: Stand_Alone_Lasso_RRE; Location: 0 - 82; Score: 75.1

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
CcpA	Catabolite control protein A
DasR	N-acetylglucosamine dependent repressor
FuR variant 2	Ferric Uptake Regulator
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

NZ_CABGTR010000001.1 - Region 2 - cyclic-lactone-autoinducer

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Location: 706,956 - 727,684 nt. (total: 20,729 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001291.3	0.41	ribosomal	enterocin NKR-5-3B	Enterococcus faecium
BGC0001948.3	0.37	other (other)	naseseazine C, C3-aryl pyrroloindolines	Streptomyces sp.
BGC0000046.4	0.35	PKS	depudecin	Alternaria brassicicola
BGC0002227.3	0.31	NRPS	AKML B, AKML D, AKML A, AKML C	Aspergillus luchuensis IFO 4308
BGC0002667.2	0.30	ribosomal	estericin A	Clostridium estertheticum
BGC0001246.3	0.30	PKS	trans-resorcylide	Sarocladium zeae
BGC0000688.4	0.29	terpene	copalyl diphosphate	Diaporthe amygdali
BGC0001954.2	0.28	NRPS, PKS	wortmanamide A, wortmanamide B	Talaromyces wortmannii
BGC0001366.5	0.27	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0002058.3	0.27	NRPS, PKS	mutanocyclin	Streptococcus mutans B04Sm5

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001291.3	0.41	ribosomal	enterocin NKR-5-3B	Enterococcus faecium
BGC0001948.3	0.37	other (other)	naseseazine C, C3-aryl pyrroloindolines	Streptomyces sp.
BGC0000046.4	0.35	PKS	depudecin	Alternaria brassicicola
BGC0002227.3	0.31	NRPS	AKML B, AKML D, AKML A, AKML C	Aspergillus luchuensis IFO 4308
BGC0002667.2	0.30	ribosomal	estericin A	Clostridium estertheticum
BGC0001246.3	0.30	PKS	trans-resorcylide	Sarocladium zeae
BGC0000688.4	0.29	terpene	copalyl diphosphate	Diaporthe amygdali
BGC0001954.2	0.28	NRPS, PKS	wortmanamide A, wortmanamide B	Talaromyces wortmannii
BGC0001366.5	0.27	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0002058.3	0.27	NRPS, PKS	mutanocyclin	Streptococcus mutans B04Sm5

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.50 out of 23.79

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.08 out of 23.79

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 28.99 out of 30.25

Confidence: strong

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26

Confidence: medium

Additional weak hits (1):

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 20.68 out of 29.72

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
ColR	Phenol-responsive regulator
IolR	Regulator of the inositol catabolism

NZ_CABGTR010000003.1 - Region 1 - lanthipeptide-class-ii

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Location: 110,719 - 133,703 nt. (total: 22,985 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: deacetylase

FN307_RS09520: acetylornithine deacetylase

smcogs: SMCOG1247: acetylornithine deacetylase

Lyases: cyclase

FN307_RS09570: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.56	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.5	0.51	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000516.4	0.49	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000527.5	0.49	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000623.3	0.48	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000558.5	0.48	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000521.3	0.48	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0002698.2	0.46	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001210.5	0.45	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000626.3	0.45	ribosomal	thuricin	Bacillus thuringiensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.56	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.5	0.51	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000516.4	0.49	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000527.5	0.49	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000623.3	0.48	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000558.5	0.48	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000521.3	0.48	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0002698.2	0.46	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001210.5	0.45	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000626.3	0.45	ribosomal	thuricin	Bacillus thuringiensis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for FN307_RS09570

FN307_RS09560

Leader:

MEAEKIVGM

Core:

QFEDLSKEEMNFIAGGNNNARISPTIVTPVTPYTSYVASAAGSAALSAVSGLVSYTKKCF

Core with dehydrations:

QFEDLDhaKEEMNFIAGGNNNARIDhaPDhbIVDhbPVDhbPYDhbDhaYVADhaAAGDhaAALDhaAVDhaGLVDhaYDhbKKCysF

antiSMASH-DB 4.0 matches for FN307_RS09560

100.0%

NC_021023.1and 10 others:

NZ_CABGJL010000002.1 Lanthipeptides: FN048_RS03100_lanthipeptideNZ_CABGPX010000017.1 Lanthipeptides: FN189_RS10930_lanthipeptideNZ_CABGTR010000003.1 Lanthipeptides: FN307_RS09560_lanthipeptideNZ_CP097048.1 Lanthipeptides: M2906_RS12945_lanthipeptideNZ_CP116962.1 Lanthipeptides: PO880_RS01550_lanthipeptideNZ_GG670379.1 Lanthipeptides: EFDG_RS12820_lanthipeptideNZ_GL454198.1 Lanthipeptides: HMPREF9500_RS14730_lanthipeptideNZ_JTKS01000015.1 Lanthipeptides: QI17_RS10290_lanthipeptideNZ_KB944666.1 Lanthipeptides: WMS_RS03550_lanthipeptideNZ_KZ845971.1 Lanthipeptides: EB55_RS12320_lanthipeptide

Lanthipeptides: ENT_RS13925_lanthipeptide

QFEDLSKEEMNFIAGGNNNARISPTIVTPVTPYTSYVASAAGSAALSAVSGLVSYTKKCF

35.0%

NZ_GG730336.1:

Lanthipeptides: SAUG_RS08755_lanthipeptide

GNNNARISPTIVTPVTPYTSYVASAAGSAALSAVSGLVSYTKKCF

G + +PTI +P TPY ++ A +SAVSGLVSYTK C

GTVEPQATPTIASPFTPYAIEISIGA---TVSAVSGLVSYTKDCL

30.0%

NZ_FPCC01000026.1:

Lanthipeptides: BM377_RS12905_lanthipeptide

FEDLSKEEMNFIAG-GNNNARISPTIVTPVTPYTSYVASAAGSAALSAVS

FEDL+ E+M G G+ +A +P I+ P S A + ALS +S

FEDLNTEDMQNTQGAGDVDAETTPVIM----PICSPSAVVNPTLALSLIS

with 25 more sequence matches

Only the first 10 are displayed here.

28.3%

NZ_FPCC01000026.1:

Lanthipeptides: BM377_RS12900_lanthipeptide

FEDLSKEEM-NFIAGGNNNARISPTI--VTPVTPYTS

FEDL+ E+M N GG+ NA TI +T V P S

FEDLNTEDMQNTQGGGDVNAETIVTISNLTLVGPIVS

28.3%

NZ_JACSPZ010000014.1:

Lanthipeptides: H9635_RS18390_lanthipeptide

VTPYTSYVASAAGSA------ALSAVSGLVSYTKKCF

V P+T+ + SAA + A+SA+SGLVSY K C

VEPHTTPILSAATKSSKKCLGAISAISGLVSYNKDCL

27.4%

NZ_CP011152.1and 1 other:

NZ_CP011152.1 Lanthipeptides: WR47_RS28810_lanthipeptide

Lanthipeptides: WR47_RS28810_lanthipeptide

FEDLSKEEM-NFIAGGNNNARISPT-IVTPVTPYTSYVASAAGSAALSAVSGLVSYTKKC

E++ E+ N + G+ A S I+TP TP S G A + TK+C

LEEIQGNELLNAVGAGDVQANTSTVQILTPRTPIISNTLGNKGHAC--------TITKEC

26.7%

NC_021023.1and 9 others:

NZ_CABGJL010000002.1 Lanthipeptides: FN048_RS03095_lanthipeptideNZ_CABGPX010000017.1 Lanthipeptides: FN189_RS10935_lanthipeptideNZ_CABGTR010000003.1 Lanthipeptides: FN307_RS09565_lanthipeptideNZ_CP097048.1 Lanthipeptides: M2906_RS12940_lanthipeptideNZ_CP116962.1 Lanthipeptides: PO880_RS01555_lanthipeptideNZ_GG670379.1 Lanthipeptides: EFDG_RS12825_lanthipeptideNZ_GL454198.1 Lanthipeptides: HMPREF9500_RS14725_lanthipeptideNZ_KB944666.1 Lanthipeptides: WMS_RS03545_lanthipeptideNZ_KZ845971.1 Lanthipeptides: EB55_RS12315_lanthipeptide

Lanthipeptides: ENT_RS13920_lanthipeptide

NNNARISPTIVTPVTPYTSYVASAAGSAALSAVS

N+NARISPTI+ S +S GS LSA +

NDNARISPTIILSAATVASAASSFVGSYTLSAFT

26.7%

NZ_BMSZ01000006.1and 4 others:

NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12790_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS18195_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptide

Lanthipeptides: IE135_RS12790_lanthipeptide

ARISPTIVTPVTPYTSYVASAAGSAALSAVSGLVSYTKKC

A I+PTIV P T T+ + A SAA+ TK+C

AGITPTIV-PATAVTTVIVGA--SAAMQGGCPTSGCTKRC

26.7%

NZ_CP026035.1:

Lanthipeptides: C2H96_RS00305_lanthipeptide

TPYTSYVASAAG-------SAALSAVSGLVSYTKKCF

TP S V SA G S SA+SG+VS+ K C

TPAVSAVLSAVGRSTRLCISGIGSAISGIVSHNKDCL

26.7%

NZ_FPCC01000026.1:

Lanthipeptides: BM377_RS12915_lanthipeptide

FEDLSKEEMNFIAGGNNNARISPTIVTPVTPYTSYVASAAGSAALSAVSGLVSYTKKCF

+EDL+ E+M G + + T+ +T A S +SG +S KKC

YEDLNTEDMQNTQGAGDTE--AETVSLAIT-----------GAIASVISGAISL-KKCV

26.7%

NZ_KN125582.1:

Lanthipeptides: DJ91_RS27550_lanthipeptide

NARISPTIVTPVTPYTSYVASAAGSAALSAVSGLVSYTKKCF

+ R PT++ S ++SA ++ +SA+SGLVSY K C

DTRTHPTVIV-----VSRISSAKCASTISAISGLVSYNKDCL

25.0%

NZ_CP011152.1and 3 others:

NZ_CP011152.1 Lanthipeptides: WR47_RS28830_lanthipeptideNZ_CP011152.1 Lanthipeptides: WR47_RS28835_lanthipeptideNZ_CP011152.1 Lanthipeptides: WR47_RS28830_lanthipeptide

Lanthipeptides: WR47_RS28835_lanthipeptide

VTP-VTPYTSYVASAAGSAALSAVSGLVSYTKKC

VTP TP + +A+AAG A +SAV + + KC

VTPQATPTVTILATAAGGAVISAVLPTLKCSSKC

25.0%

NZ_CP094446.1:

Lanthipeptides: L3476_RS23825_lanthipeptide

TIVTPVTPYTSYVASAAGSAALSAVSGLVSYTKKCF

TIV+ VT + SA GSA +SG++S+ K C

TIVSAVTRSSKPCISAIGSA----ISGIISHNKDCL

MIBiG 4.0 matches for FN307_RS09560

11.7%

BGC0002130.3 (QKI29070.1):

Lanthipeptide: cacaoidin

PVTPYTSYVASAAGSAAL

P T Y S AS + +A+

PCTIYASVSASISATASW

6.7%

BGC0000582.4 (ADR72962.1):

Linaridin: cypemycin

TPVTP

TP TP

TPATP

FN307_RS09565

Leader:

MDEKQLDSLVGQKFEDLSKEEMNFIAGG

Core:

NDNARISPTIILSAATVASAASSFVGSYTLSAFTKCR

Core with dehydrations:

NDNARIDhaPDhbIILDhaAADhbVADhaAADhaDhaFVGDhaYDhbLDhaAFDhbKCysR

antiSMASH-DB 4.0 matches for FN307_RS09565

100.0%

NC_021023.1and 9 others:

Lanthipeptides: ENT_RS13920_lanthipeptide

NDNARISPTIILSAATVASAASSFVGSYTLSAFTKCR

97.3%

NZ_JTKS01000015.1:

Lanthipeptides: QI17_RS10285_lanthipeptide

NDNARISPTIILSAATVASAASSFVGSYTLSAFTKCR

NDNARISP IILSAATVASAASSFVGSYTLSAFTKCR

NDNARISPKIILSAATVASAASSFVGSYTLSAFTKCR

43.2%

NZ_CP044545.1:

Lanthipeptides: F7984_RS17855_lanthipeptide

NARISPTIILSAATVASAASSFVGSYTLSA

N I P AATV SA +SFVGSY ++A

NGEIQPQGT-PAATVISALASFVGSYLVTA

with 20 more sequence matches

Only the first 10 are displayed here.

37.8%

NZ_JACSNF010000005.1and 1 other:

NZ_LMPR01000013.1 Lanthipeptides: ASF99_RS16385_lanthipeptide

Lanthipeptides: KNQ12_RS14670_lanthipeptide

SPTIILSAATVASAASSFVGSYTLSAFTKC

S + + ++ V SA SFVGSY SA KC

STDVDVRSSLVCSALLSFVGSYLASAGLKC

34.0%

NZ_CP099547.1:

Lanthipeptides: allorf_0559994_0560212_lanthipeptide

SPTIILSA---ATVASAASSFVGSYTL----SAFTKCR

+PT+ S+ ATV+ A S + S+T+ SA+TKCR

TPTVTTSSVPCATVSKAVSGALVSWTVSFVASAWTKCR

32.4%

NZ_NVMQ01000017.1:

Lanthipeptides: CON32_RS17790_lanthipeptide

NARISPTIILSAATVASAASSFVGSYTLSAFTKC

+ R +P+ +L+ SFV SY SA KC

DPRTTPSPLLA---------SFVASYIASAEFKC

29.7%

NZ_FNYB01000021.1:

Lanthipeptides: BMZ34_RS24355_lanthipeptide

NARISPTIILSAATVASAASSFVGSYTLSAFTKC

+ R +P+ +L+ SFV SY SA +C

DPRTTPSPLLA---------SFVASYIASAEFRC

29.7%

NZ_FNYB01000021.1:

Lanthipeptides: BMZ34_RS24360_lanthipeptide

NARISPTIILSAATVASAASSFVGSYTLSAFTKC

+ R +P+ +L+ SFV SY SA +C

DPRTTPSPLLA---------SFVASYIASAQYRC

29.7%

NZ_KB976303.1:

Lanthipeptides: IGY_RS26050_lanthipeptide

NARISPTIILSAATVASAASSFVGSYTLSAFTKC

+ R +P+ +L+ SFV SY SA +C

DPRTTPSPLLA---------SFVASYIASAQFRC

29.7%

NZ_LT800494.1:

Lanthipeptides: B7E07_RS02625_lanthipeptide

NARISPTIILSAATVASAASSFVGSYTLSA

+ +PTI L++A V + S+F S T++A

EPQATPTIALTSALVGAPVSAF-ASLTITA

29.7%

NZ_NAOJ01000022.1:

Lanthipeptides: B5K31_RS08015_lanthipeptide

TVASAASSFVGSYTLSAFTKC

T+ SA SF+ SY SA T+C

TICSATLSFIASYLGSAQTRC

27.0%

NC_003028.3and 46 others:

NC_003098.1 Lanthipeptides: SPR_RS08865_lanthipeptideNC_011900.1 Lanthipeptides: SPN23F_RS10050_lanthipeptideNC_012466.1 Lanthipeptides: SPJ_RS09635_lanthipeptideNZ_CFDV01000030.1 Lanthipeptides: AQB43_RS08320_lanthipeptideNZ_CFVJ01000005.1 Lanthipeptides: AP598_RS03265_lanthipeptideNZ_CGGJ01000006.1 Lanthipeptides: AP607_RS03205_lanthipeptideNZ_CHVQ01000007.1 Lanthipeptides: AQF85_RS04285_lanthipeptideNZ_CJZM01000008.1 Lanthipeptides: AEE29_RS04155_lanthipeptideNZ_CLHL01000007.1 Lanthipeptides: AE723_RS05750_lanthipeptideNZ_CMIW01000004.1 Lanthipeptides: AD046_RS04075_lanthipeptideNZ_CMKL01000017.1 Lanthipeptides: AD734_RS09110_lanthipeptideNZ_CP035244.1 Lanthipeptides: EQH36_RS09105_lanthipeptideNZ_CP035253.1 Lanthipeptides: EQH27_RS09740_lanthipeptideNZ_CP082820.1 Lanthipeptides: K8B76_RS08865_lanthipeptideNZ_CPPE01000023.1 Lanthipeptides: AD654_RS06875_lanthipeptideNZ_CPRX01000013.1 Lanthipeptides: AEE77_RS05820_lanthipeptideNZ_CPTT01000011.1 Lanthipeptides: AEH42_RS06000_lanthipeptideNZ_CRAW01000006.1 Lanthipeptides: AK725_RS04395_lanthipeptideNZ_CRXO01000010.1 Lanthipeptides: AKU38_RS05260_lanthipeptideNZ_FCRW01000008.1 Lanthipeptides: A1N73_RS07425_lanthipeptideNZ_FDDE01000015.1 Lanthipeptides: A1A23_RS09705_lanthipeptideNZ_FDFR01000008.1 Lanthipeptides: A1O50_RS09320_lanthipeptideNZ_FDGF01000009.1 Lanthipeptides: A0899_RS06595_lanthipeptideNZ_FDQP01000009.1 Lanthipeptides: A1S42_RS08050_lanthipeptideNZ_FECM01000008.1 Lanthipeptides: A1930_RS06475_lanthipeptideNZ_FEEQ01000001.1 Lanthipeptides: A1T31_RS01145_lanthipeptideNZ_FEOS01000003.1 Lanthipeptides: A1178_RS03085_lanthipeptideNZ_FFTU01000009.1 Lanthipeptides: A1K37_RS06335_lanthipeptideNZ_FHJP02000011.1 Lanthipeptides: A1O79_RS07375_lanthipeptideNZ_FHRS02000028.1 Lanthipeptides: A1898_RS09820_lanthipeptideNZ_FIXQ01000010.1 Lanthipeptides: AZ721_RS04790_lanthipeptideNZ_FZDX01000018.1 Lanthipeptides: CFW91_RS09480_lanthipeptideNZ_FZEI01000008.1 Lanthipeptides: CFW58_RS06410_lanthipeptideNZ_JACVHZ010000010.1 Lanthipeptides: ICJ99_RS03880_lanthipeptideNZ_JAGFAE010000038.1 Lanthipeptides: J5E60_RS09005_lanthipeptideNZ_JALDUX010000010.1 Lanthipeptides: M1F92_RS09535_lanthipeptideNZ_JAMYJM010000002.1 Lanthipeptides: NKE69_RS04885_lanthipeptideNZ_LR216014.1 Lanthipeptides: E0F05_RS09385_lanthipeptideNZ_LR216016.1 Lanthipeptides: E0F10_RS10160_lanthipeptideNZ_LR216019.1 Lanthipeptides: E0E94_RS09635_lanthipeptideNZ_LR216027.1 Lanthipeptides: E0E81_RS09205_lanthipeptideNZ_LR216049.1 Lanthipeptides: E0E96_RS09540_lanthipeptideNZ_LR216064.1 Lanthipeptides: E0F31_RS09525_lanthipeptideNZ_LR536843.1 Lanthipeptides: E0F34_RS09600_lanthipeptideNZ_MRXY01000010.1 Lanthipeptides: BTU63_RS06305_lanthipeptideNZ_NANQ01000003.1 Lanthipeptides: B5K28_RS01935_lanthipeptide

Lanthipeptides: SP_RS09795_lanthipeptide

VASAASSFVGSYTLSAFTKC

+ SA SF+ SY SA T+C

ICSATLSFIASYLGSAQTRC

27.0%

NZ_CP041405.1:

Lanthipeptides: FLT43_RS14405_lanthipeptide

VASAASSFVGSYTLSAFTKC

V A S+V SY SA KC

VCGAGISYVASYLASAAFKC

allorf_127304_127447

Leader:

MLLLIKTYNYLHSYFILKKYGPVNTSLVHIGGA

Core:

PRNICTENSDSDYL

Core with dehydrations:

PRNICysDhbENDhaDDhaDYL

antiSMASH-DB 4.0 matches for allorf_127304_127447

100.0%

NC_021023.1and 9 others:

NZ_CABGJL010000002.1 Lanthipeptides: allorf_195639_195782_lanthipeptideNZ_CABGPX010000017.1 Lanthipeptides: allorf_61913_62056_lanthipeptideNZ_CABGTR010000003.1 Lanthipeptides: allorf_127304_127447_lanthipeptideNZ_CP097048.1 Lanthipeptides: allorf_2681863_2682006_lanthipeptideNZ_CP116962.1 Lanthipeptides: allorf_0340612_0340755_lanthipeptideNZ_GL454198.1 Lanthipeptides: allorf_096858_097001_lanthipeptideNZ_JTKS01000015.1 Lanthipeptides: allorf_208570_208713_lanthipeptideNZ_KB944666.1 Lanthipeptides: allorf_0096922_0097065_lanthipeptideNZ_KZ845971.1 Lanthipeptides: allorf_2372960_2373103_lanthipeptide

Lanthipeptides: allorf_2915554_2915697_lanthipeptide

PRNICTENSDSDYL

22.2%

NZ_CP114875.1:

Lanthipeptides: O4Z47_RS14375_lanthipeptide

NICTENSDSDYL

+ICT S+ D+L

DICTLTSECDHL

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.00 out of 20.47

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.36 out of 26.06

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 22.72 out of 24.78

Confidence: strong

Additional weak hits (2):

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 24.35 out of 33.73

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.58 out of 29.65

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

FN307_RS09560 - Class II

Cleavage pHMM score: 1.60

RODEO score: 0

Monoisotopic mass: 6038.1 Da

Molecular weight: 6041.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 6059.7 Da N = 1; 6077.8 Da N = 2; 6095.8 Da N = 3; 6113.8 Da N = 4; 6131.8 Da N = 5; 6149.8 Da N = 6; 6167.9 Da N = 7; 6185.9 Da N = 8; 6203.9 Da N = 9; 6221.9 Da N = 10; 6239.9 Da N = 11; 6258.0 Da N = 12

FN307_RS09565 - Class II

Cleavage pHMM score: -0.50

RODEO score: 0

Monoisotopic mass: 3591.9 Da

Molecular weight: 3594.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3612.0 Da N = 1; 3630.1 Da N = 2; 3648.1 Da N = 3; 3666.1 Da N = 4; 3684.1 Da N = 5; 3702.1 Da N = 6; 3720.2 Da N = 7; 3738.2 Da N = 8; 3756.2 Da N = 9; 3774.2 Da N = 10

allorf_127304_127447 - Class II

Cleavage pHMM score: -4.70

RODEO score: 0

Monoisotopic mass: 1571.7 Da

Molecular weight: 1572.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1590.7 Da N = 1; 1608.7 Da N = 2

TFBS definitions

Regulator	Description
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
VqsM	Regulator of quorum-sensing signalling systems

NZ_CABGTR010000005.1 - Region 1 - azole-containing-RiPP,cyclic-lactone-autoinducer,terpene-precursor

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Location: 70,231 - 110,700 nt. (total: 40,470 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)
azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Azole RiPPs

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

FN307_RS12245: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Hydrolases: peptidase

FN307_RS12205: methionine aminopeptidase

smcogs: SMCOG1172: methionine aminopeptidase

Ligases: synthetase

FN307_RS12170: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000540.5	0.45	ribosomal	paenibacillin	Paenibacillus polymyxa OSY-DF
BGC0001291.3	0.38	ribosomal	enterocin NKR-5-3B	Enterococcus faecium
BGC0000607.5	0.35	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0002579.2	0.34	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0002311.3	0.32	ribosomal	cutimycin	Cutibacterium acnes KPA171202
BGC0000605.5	0.29	ribosomal	GE37468	Streptomyces sp. ATCC 55365
BGC0000624.3	0.29	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0000494.5	0.28	ribosomal	uberolysin	Streptococcus uberis
BGC0000606.5	0.28	ribosomal	lactazole	Streptomyces lactacystinaeus
BGC0001640.3	0.28	ribosomal	kocurin	Kocuria rosea

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.54	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.51	terpene	boleracene	Brassica oleracea var. oleracea
BGC0000607.5	0.50	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0000540.5	0.50	ribosomal	paenibacillin	Paenibacillus polymyxa OSY-DF
BGC0002398.2	0.49	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000605.5	0.47	ribosomal	GE37468	Streptomyces sp. ATCC 55365
BGC0002311.3	0.46	ribosomal	cutimycin	Cutibacterium acnes KPA171202
BGC0002309.2	0.46	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001291.3	0.45	ribosomal	enterocin NKR-5-3B	Enterococcus faecium
BGC0001173.5	0.45	ribosomal	plantazolicin	Bacillus pumilus ATCC 7061

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

FN307_RS12170: PT_FPPS_like

Domain 1 (29 - 276): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.51 out of 27.55

Confidence: medium

Additional weak hits (4):

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.21 out of 30.11

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 22.85 out of 32.93

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 20.21 out of 30.22

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 21.53 out of 32.38

Confidence: weak

(Thi)azol(in)e containing peptide predictions

No core peptides found.

Terpene

TFBS Finder

Azole RiPPs

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
GnfM	Regulator of nitrogen-fixation genes

Core peptide predictions

No core peptides found.

NZ_CABGTR010000006.1 - Region 1 - RiPP-like

Download region GenBank file

Download region SVG

Location: 74,109 - 85,152 nt. (total: 11,044 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acetyltransferase

FN307_RS13440: Chloramphenicol acetyltransferase

smcogs: SMCOG1156: Chloramphenicol acetyltransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001510.5	0.31	other (other)	anisomycin	Streptomyces hygrospinosus
BGC0000770.4	0.31	saccharide	lipo-oligosaccharide	Campylobacter jejuni
BGC0000818.5	0.28	NRPS	notoamide A	Aspergillus versicolor
BGC0000762.3	0.27	saccharide	exopolysaccharide	Rhizobium leguminosarum bv. viciae
BGC0000298.5	0.25	NRPS	aeruginosin 98-A, aeruginosin 98-B, aeruginosin 98-C	Microcystis aeruginosa NIES-98
BGC0000795.3	0.24	saccharide	S-layer glycan	Aneurinibacillus thermoaerophilus
BGC0000806.5	0.24	saccharide	phosphonoglycans	Glycomyces sp. NRRL B-16210
BGC0001412.3	0.24	saccharide	polysaccharide C	Bacteroides fragilis
BGC0001894.2	0.20	saccharide	heteropolysaccharide (HePS)	Lactobacillus plantarum
BGC0002550.2	0.19	PKS	lobophorin CR4	Streptomyces olivaceus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001510.5	0.31	other (other)	anisomycin	Streptomyces hygrospinosus
BGC0000770.4	0.31	saccharide	lipo-oligosaccharide	Campylobacter jejuni
BGC0000818.5	0.28	NRPS	notoamide A	Aspergillus versicolor
BGC0000762.3	0.27	saccharide	exopolysaccharide	Rhizobium leguminosarum bv. viciae
BGC0000298.5	0.25	NRPS	aeruginosin 98-A, aeruginosin 98-B, aeruginosin 98-C	Microcystis aeruginosa NIES-98
BGC0000795.3	0.24	saccharide	S-layer glycan	Aneurinibacillus thermoaerophilus
BGC0000806.5	0.24	saccharide	phosphonoglycans	Glycomyces sp. NRRL B-16210
BGC0001412.3	0.24	saccharide	polysaccharide C	Bacteroides fragilis
BGC0001894.2	0.20	saccharide	heteropolysaccharide (HePS)	Lactobacillus plantarum
BGC0002550.2	0.19	PKS	lobophorin CR4	Streptomyces olivaceus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05

Confidence: medium

TFBS Finder

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production