LOCUS       NZ_CAAHQE010000005     20873 bp    DNA     linear   CON 19-DEC-2024
DEFINITION  Streptococcus pyogenes strain Bel002, whole genome shotgun sequence.
ACCESSION   NZ_CAAHQE010000005
VERSION     NZ_CAAHQE010000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (03-APR-2019) WTSI, Pathogen Informatics, Wellcome Trust
            Sanger Institute, CB10 1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900985135.1-RS_2024_12_19
            Annotation Date                   :: 12/19/2024 10:09:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,745
            CDSs (total)                      :: 1,683
            Genes (coding)                    :: 1,623
            CDSs (with protein)               :: 1,623
            Genes (RNA)                       :: 62
            rRNAs                             :: 3, 4, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 3, 1 (16S, 23S)
            tRNAs                             :: 49
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 60
            CDSs (without protein)            :: 60
            Pseudo Genes (ambiguous residues) :: 0 of 60
            Pseudo Genes (frameshifted)       :: 28 of 60
            Pseudo Genes (incomplete)         :: 32 of 60
            Pseudo Genes (internal stop)      :: 14 of 60
            Pseudo Genes (multiple problems)  :: 11 of 60
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:22:44
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 84535
            Orig. end                         :: 105408
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CAAHQE010000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20873
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="1"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..20873
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20873
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10873](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10873
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    complement(765..785)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 25.95"
                     /tool="antismash"
     misc_feature    1659..1672
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 21.93"
                     /tool="antismash"
     gene            2046..2276
                     /locus_tag="E9931_RS06440"
                     /old_locus_tag="SAMEA3919035_01255"
     CDS             2046..2276
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003105222.1"
                     /locus_tag="E9931_RS06440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_01255"
                     /product="YkuJ family protein"
                     /protein_id="WP_002983885.1"
                     /transl_table=11
                     /translation="MESHLVRIINRLELMVTDGGNLKRNFERDGVVVAEVAFSNDPENG
                     PVFTLRDVEARESYSFDSIDLIAMEIYDLLY"
     gene            2403..3089
                     /locus_tag="E9931_RS06445"
                     /old_locus_tag="SAMEA3919035_01256"
     CDS             2403..3089
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1096: polar amino
                     acid ABC transporter, inner membrane"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011018000.1"
                     /locus_tag="E9931_RS06445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_01256"
                     /product="amino acid ABC transporter permease"
                     /protein_id="WP_032464463.1"
                     /transl_table=11
                     /translation="MDLSFLPKYWAYFNYGVLVTIMISISVVFFGTLIGVLVTLIKRSH
                     VKPLTWVVNLYVWIFRGTPMVVQIMIAFAWMHFNNMPTIGFGVLDLDFSRLLPGIIIIS
                     LNSGAYISEIVRAGIEAVPKGQLEAAYSLGIRPQNAMRYVILPQAFKNILPALGNEFIT
                     IIKDSALLQTIGVMELWNGAQSVVTATYSPISPLLVAAFYYLMVTTVMAQLLAVLERHM
                     SQGGNH"
     gene            3089..3823
                     /locus_tag="E9931_RS06450"
                     /old_locus_tag="SAMEA3919035_01257"
     CDS             3089..3823
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407690.1"
                     /locus_tag="E9931_RS06450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_01257"
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="WP_002989107.1"
                     /transl_table=11
                     /translation="MTEAIISIKDLHKYYGHNEVLKGIDLDIMPGEVVVIIGPSGSGKS
                     TLLRTMNLLEVPTKGQIRFEGIDITDKKNDIFSMREKMGMVFQQFNLFPNMTILENITL
                     SPIKTKGMAKAEADKTALSLLDKVGLSEKAKAYPASLSGGQQQRIAIARGLAMDPDVLL
                     FDEPTSALDPEMVGEVLAVMQDLAKSGMTMVIVTHEMGFAKEVADRVIFMDGGVIVEEG
                     SPNQLFDLTKEERTKDFLSRVL"
     gene            3972..5381
                     /locus_tag="E9931_RS06455"
                     /old_locus_tag="SAMEA3919035_01258"
     CDS             3972..5381
                     /EC_number="4.1.99.3"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003904 - deoxyribodipyrimidine
                     photo-lyase activity [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989109.1"
                     /locus_tag="E9931_RS06455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_01258"
                     /product="deoxyribodipyrimidine photo-lyase"
                     /protein_id="WP_136293879.1"
                     /transl_table=11
                     /translation="MVSVMWFRRDLRIDDQKALAHVIASQSPTLCVFQFNKEQLNLLHS
                     RNQSSFITSVLAFRKLLKCEGIDLYLMYGDLMTCFEQLLTQLKDWTDVYFNYDESGYGR
                     LRDQKAAQFFKKNGIAVHTYQDHYLHGSQEIINQSGQPYKVFTPYYRIWQNYPKETPIK
                     VELSQGRWLNLETPDDVLRTVESFKDEKYQDVATFDEASKQLNRFIQDQLAAYHANRDF
                     PAQLGTSRLSPFLRIGAIGIRTVYHAVRQAPNSLGQATFFKELAWRDFYNMVYVAYPDQ
                     KTQPIQKAFSQIEWVNNPDWFQLWKEGKTGYPIVDAAMLQLQKTGWMHNRLRMIVASFL
                     TKDLLCDWRLGEQYFQQQLIDYDAASNIGGWQWAASTGTDAVPYFRIFNPVTQGKRFDP
                     KGEFIKAYLPQLEHVPEKYLHEPWKMPKNLQESVSCIIGTDYPQPIVDHAKQREQAIAK
                     YEWAKEKAKIE"
     misc_feature    complement(5497..5508)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.16"
                     /tool="antismash"
     misc_feature    5526..5541
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 22.0"
                     /tool="antismash"
     gene            5559..7253
                     /locus_tag="E9931_RS06460"
                     /old_locus_tag="SAMEA3919035_01259"
     CDS             5559..7253
                     /EC_number="5.4.2.-"
                     /GO_function="GO:0016868 - intramolecular
                     phosphotransferase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635581.1"
                     /locus_tag="E9931_RS06460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_01259"
                     /product="phospho-sugar mutase"
                     /protein_id="WP_032467264.1"
                     /transl_table=11
                     /translation="MTYNEVYQEWLHNNDLSDDIKADLAAIKDNEAEIQDRFYKTLEFG
                     TAGLRGKLGAGTNRMNTYMVGKAAQALANTIIDHGPEAVKKGIAVSYDVRYQSRTFAEL
                     TCSIMAANGIKAHLYKGIRPTPMCSYAIRALGCISGVMITASHNPQAYNGYKAYWQEGS
                     QILDDIADQIAQHMAALTQYEEIKQMPFEKALDSGLVTYIDESIEEAYKKEVLGLTIND
                     TDIDKSVRVVYTPLNGVGNLPVREVLRRRGFENVYVVPEQEMPDPDFTTVGYPNPEVPK
                     TFAYSEKLGKAVDADILIATDPDCDRVALEVKNAVGDYVFLNGNKIGALLSYYIFSQRF
                     DLGNLPANPVLVKSIVTGDLSRAIASHYGIETVETLTGFKNICGKANEYDVTKQKNYLF
                     GYEESIGFCYGTFVRDKDAVSASMMIVEMAAYYKKKGQNLLDVLQTIYATFGYYNERQI
                     ALELEGIEGQKRIARIMEDFRQTPIASVAEMALDKTIDFIDGYQDFPKQNCLKFYLDDG
                     SWYALRPSGTEPKIKFYLYTIGQTQENSATKLDAIEAACRTKINQVN"
     gene            7461..8315
                     /locus_tag="E9931_RS06465"
                     /old_locus_tag="SAMEA3919035_01260"
     CDS             7461..8315
                     /GO_function="GO:0004488 - methylenetetrahydrofolate
                     dehydrogenase (NADP+) activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922486.1"
                     /locus_tag="E9931_RS06465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_01260"
                     /product="bifunctional methylenetetrahydrofolate
                     dehydrogenase/methenyltetrahydrofolate cyclohydrolase"
                     /protein_id="WP_002989114.1"
                     /transl_table=11
                     /translation="MTELIDGKALAQKMQQELAAKVNNLKQKKGIVPGLAVILVGDDPA
                     SQVYVRNKERAALTVGFKSETVRLSEFICQEELIAVIERYNADNTIHGILVQLPLPNHI
                     NDKKIILAIDPKKDVDGFHPMNTGHLWSGRPLMVPCTPSGIMELLREYNVNLEGKHAVI
                     IGRSNIVGKPMAQLLLDKNATVTLTHSRTRQLEEVCRCADVLIVAIGQGHFITKQYIKE
                     GAIVIDVGMNRDDNGKLIGDVAFDEVAEVAAKITPVPGGVGPMTIAMLLEQTYQSALRS
                     THK"
     gene            8468..9808
                     /gene="xseA"
                     /locus_tag="E9931_RS06470"
                     /old_locus_tag="SAMEA3919035_01261"
     CDS             8468..9808
                     /EC_number="3.1.11.6"
                     /GO_component="GO:0009318 - exodeoxyribonuclease VII
                     complex [Evidence IEA]"
                     /GO_function="GO:0008855 - exodeoxyribonuclease VII
                     activity [Evidence IEA]"
                     /GO_process="GO:0006308 - DNA catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="xseA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989115.1"
                     /locus_tag="E9931_RS06470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_01261"
                     /product="exodeoxyribonuclease VII large subunit"
                     /protein_id="WP_136293880.1"
                     /transl_table=11
                     /translation="MADYLTVTHLTKYLKLKFDRDPYLERVYLTGQVSNFRKRPTHQYF
                     SLKDESAVIQATMWAGVYKKLGFDLEEGMKINVIGRVQLYEPSGSYSIVIEKAEPDGIG
                     ALALQFEQLKKKLTAEGYFEQKHKQALPQFVSKIGVITSPSGAVIRDIITTVSRRFPGV
                     EILLFPTKVQGDGAAQEVVANIRRANQREDLDLLIVGRGGGSIEDLWAFNEEIVVQAIF
                     ESQLPVISSVGHETDTTLADFVADRRAATPTAAAELATPITKTDLMSWIVERQNRSYQA
                     CLRRIKQRREWVDKLSQSVIFRQPERLYDAYLQKIDRLSMTLMNTMKDRLSSAKENKVQ
                     LDHALANSQLQTKIERYQDRVATAKRLLMANMARQYDSQLARFEKAQDALLSLDVSRII
                     ARGYAMIEKNQALVASVSQITKGDQLTIKMRDGQLDVEVKDVKNENI"
     gene            9786..10001
                     /locus_tag="E9931_RS06475"
                     /old_locus_tag="SAMEA3919035_01262"
     CDS             9786..10001
                     /EC_number="3.1.11.6"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983901.1"
                     /locus_tag="E9931_RS06475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_01262"
                     /product="exodeoxyribonuclease VII small subunit"
                     /protein_id="WP_002983901.1"
                     /transl_table=11
                     /translation="MSKTKTFEENLQDLETIVNKLENGDVPLEEAISEFQKGMLLSKEL
                     QKTLQAAEKTLVKVMQADGTEVDMDD"
     gene            10001..10873
                     /locus_tag="E9931_RS06480"
                     /old_locus_tag="SAMEA3919035_01263"
     CDS             10001..10873
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888744.1"
                     /locus_tag="E9931_RS06480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_01263"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_002983903.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.8e-52, bitscore:
                     171.8, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKLARIDEAIRRYYKTTSNGVSEELIDAILYSVDSGGKRIRPLI
                     LLEMIEGFGVSLQNAHFDLAAALEMIHTGSLIHDDLPAMDNDDYRRGRLTNHKQFGEAT
                     AILAGDSLFLDPFGLIAQAELNSEVKVALIQELSLASGTFGMVGGQMLDMKGENQALSL
                     SQLSLIHLNKTGKLLTFPFKAAALVTEQAITVRQQLEQAGMLIGHAFQIRDDILDVTAS
                     FEDLGKTPKKDLFAEKATYPSLLGLEASYQLLTESLDQALTIFQTLESDVGFKPQIITK
                     LIEGLRLNA"
     gene            10866..11693
                     /locus_tag="E9931_RS06485"
                     /old_locus_tag="SAMEA3919035_01264"
     CDS             10866..11693
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015017216.1"
                     /locus_tag="E9931_RS06485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_01264"
                     /product="TlyA family RNA methyltransferase"
                     /protein_id="WP_011017996.1"
                     /transl_table=11
                     /translation="MPKERVDVLAYKQGLFETREQAKRGVMAGLVVSVINGQRYDKPGD
                     KIDDGTELKLKGEKLKYVSRGGLKLEKGLHVFGVSVANQIGIDIGASTGGFTDVMLQDG
                     AKLVYAVDVGTNQLVWKLRQDPRVRSMEQYNFRYAQPEDFNEGQPVFASIDVSFISLSL
                     ILPALHNVLSDQGQVIALIKPQFEAGREQIGKKGIVKDKQIHEKVIQKVMDFASGYGFT
                     VKGLDFSPIQGGHGNIEFLAHLAKSQTPETLAPHLVQEVVAKAHKEFEKHEKE"
     gene            11680..12150
                     /locus_tag="E9931_RS06490"
                     /old_locus_tag="SAMEA3919035_01265"
     CDS             11680..12150
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983907.1"
                     /locus_tag="E9931_RS06490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_01265"
                     /product="arginine repressor"
                     /protein_id="WP_002983907.1"
                     /transl_table=11
                     /translation="MKKSERLELIKKMVLTHPIETQHDLLRLLAEHGLELTQATISRDM
                     NEIGIVKIPSGSGRYIYGLSQDSGKKIVQGPRSIKSTILAVSDKTKGLEQHLYLKVVPG
                     NSKLIKRYLLADFSKAIFSLIADDDSLLLIAKSPSEADMIRQEILLWMQGIT"
     gene            12172..13833
                     /gene="recN"
                     /locus_tag="E9931_RS06495"
                     /old_locus_tag="SAMEA3919035_01266"
     CDS             12172..13833
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="recN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003051804.1"
                     /locus_tag="E9931_RS06495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_01266"
                     /product="DNA repair protein RecN"
                     /protein_id="WP_002989120.1"
                     /transl_table=11
                     /translation="MLLEISIKNFAIIDEISLNFENGMTVLTGETGAGKSIIIDAMNMM
                     LGARASTEVIRRGANKAEIEGFFSVDATPELVACLESSGIAMEEELIIRRDIFANGRSV
                     SRINGQMVNLATLKQVGQFLVDIHGQHDQEELMRPQLHQQILDAFGDKAFEQLKENYQL
                     IFDRYKSLRRQVIDKQKNEKEHKDRIDMLAFQIAEIEAAALSRGEDDRLNQERDRLMNH
                     KQIADTLTNAYVMLDNDDFSSLSNIRSSMNDLLSIEQFDSEYKGMSTSISEAYYILEEV
                     SKQLSDTIDQLDFDGGRLQEIEFRLDTLNSLTRKYGGNVNDVLDYYDNIIKEYQLLTGD
                     DLSSGDLEAELKSLEKQLVAAASELSVSRHQLAEQLEAEIKAELKELYMEKADFKVHFT
                     TSKFNRDGNESLEFYISTNPGEGFKPLVKVASGGELSRLMLAIKAAISRKEDKTSIVFD
                     EVDTGVSGRVAQAIAQKIYKIGRHGQVLAISHLPQVIAIADYQYFISKESKEESTVSKV
                     RLLTPEERVEEIASMIAGTDMTQAALTQARELLAKH"
     gene            14005..14934
                     /locus_tag="E9931_RS06500"
                     /old_locus_tag="SAMEA3919035_01267"
     CDS             14005..14934
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285633.1"
                     /locus_tag="E9931_RS06500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_01267"
                     /product="LPXTG cell wall anchor domain-containing protein"
                     /protein_id="WP_002989123.1"
                     /transl_table=11
                     /translation="MTSKKACLSSIIVLASLTCGNDTVSANHLSATGDKFDDCSTLVEK
                     DVAPKDELEMLAWSSSQTTDDADRDYEDFLDDDSFNDDSFISQNETDKMFENLTDDRLL
                     DELDEEDTIEPEQNVIMPSDDELFDLTDAVETRLTVSSAPHLEAELPKPHLRSLSDTAL
                     RSGEIRGHLDNKLDALSVTATKLALTMAQKFDLTTHVYSIGESFSEVLAAHYEDRKAES
                     AFSKKKRFHLPIATPDVVIEELRRLVSSIGSSKEDVSVPYNRKLGMAVAKRKIALPQTG
                     EEFSYYPALLGLMILGLTPIMIPKKINN"
     gene            15162..16001
                     /locus_tag="E9931_RS06505"
                     /old_locus_tag="SAMEA3919035_01268"
     CDS             15162..16001
                     /GO_function="GO:0005504 - fatty acid binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002264715.1"
                     /locus_tag="E9931_RS06505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_01268"
                     /product="DegV family protein"
                     /protein_id="WP_002989125.1"
                     /transl_table=11
                     /translation="MGTIKIVTDSSITIEPELIKALDITVVPLSVMIDSKLYSDNDLKE
                     EGHFLSLMKASKSLPKTSQPPVGLFAETYENLVKKGVTDIVAIHLSPALSGTIEASRQG
                     AEIAEAPVTVLDSGFTDQAMKFQVVEAAKMAKAGASLNEILAAVQAIKSKTELYIGVST
                     LENLVKGGRIGRVTGVLSSLLNVKVVMALKNDELKTLVKGRGNKTFTKWLDSYLAKNSH
                     RPIAEIAISYAGEASLALTLKERIAAYYNHSISVLETGSIIQTHTGEGAFAVMVRYE"
     gene            15994..16836
                     /locus_tag="E9931_RS06510"
                     /old_locus_tag="SAMEA3919035_01269"
     CDS             15994..16836
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635578.1"
                     /locus_tag="E9931_RS06510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_01269"
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_011888746.1"
                     /transl_table=11
                     /translation="MNNRHLFSGIFFFVISLCLAFLLLNIIIPKSNSRLKKSDFLKKEQ
                     VAIQYVAIGDSLTEGVGDLTHQGGFVPLLTNDLSEYFKANVNHQNYGVSGDTSQQILDR
                     MIKQKQIQLSLKKADIMTLTVGGNDVMAVIRKNLADLQVSSFRKPARQYQKRLRQIIEL
                     ARKDNKDLPIFILGIYNPFYLNFPELTDMQKVIDDWNIKTKEVVGEYDRVYFVPINDLL
                     YKGINGQEGIVHSSGDQTTIVNDALFTGDHFHPNNTGYQIMSNAVMEKIKKHEKKIKP"
     gene            16814..17401
                     /locus_tag="E9931_RS06515"
                     /old_locus_tag="SAMEA3919035_01270"
     CDS             16814..17401
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922482.1"
                     /locus_tag="E9931_RS06515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_01270"
                     /product="YpmS family protein"
                     /protein_id="WP_002989129.1"
                     /transl_table=11
                     /translation="MKKKSNLNWWKWSFLCLLAFNTAFLMVIASRLIQVREPESELIAK
                     KPVKNIKIGTFVTTREQLNETVASYLKDYQTKKMSYKFYATSSSILFEGTYQLLGYEVP
                     LYIYFQPHRLENGAVQLQVISFSVGTLPLPEKDVLQYLKSSYKLPSFVKVMPNQSAIVV
                     NLQDIQNDAKVYLKAKKIDLFNDEISFNIYKK"
     gene            17500..17775
                     /locus_tag="E9931_RS06520"
                     /old_locus_tag="SAMEA3919035_01271"
     CDS             17500..17775
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0030261 - chromosome condensation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1132: DNA-binding
                     protein HU 1"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002950996.1"
                     /locus_tag="E9931_RS06520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_01271"
                     /product="HU family DNA-binding protein"
                     /protein_id="WP_002983920.1"
                     /transl_table=11
                     /translation="MANKQDLIAKVAEATELTKKDSAAAVDAVFSTIEAFLAEGEKVQL
                     IGFGNFEVRERAARKGRNPQTGAEIEIAASKVPAFKAGKALKDAVK"
     gene            complement(17865..19007)
                     /locus_tag="E9931_RS06525"
                     /old_locus_tag="SAMEA3919035_01272"
     CDS             complement(17865..19007)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1077: phage integrase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003051793.1"
                     /locus_tag="E9931_RS06525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_01272"
                     /product="site-specific integrase"
                     /protein_id="WP_003051793.1"
                     /transl_table=11
                     /translation="MWIEETDNGKFKFRENYKDPYTGTWKPVSVTMEKDNSRAYKAARK
                     ILEQKITEKIAQLKASELLFTELLDEWWAFYKKELKRSSVASLRGNIEEIRETFGIGVK
                     VVNIDPKYVQNYLDNLDCSRNKKERNKSMLNLAFDYAVGLDIIQDNPARRAKLPRVKKT
                     LEDWKKAEEKYLEEDEIKPLLKELYRRPSTYRLGLLAEFISLNGCRIGEAVSIEPCNYE
                     SKSRILQLHGTFDHTEGYRNGEKTAPKTLASYRETIMTSRELEILQELEFMNELEKNTN
                     HRYRDMGYLFTTKNGVPIQTNSFNLALKKANERLEDPITKKLTSHIFRHTLISRLAENN
                     VPLKSIMERVGHADAKTTAQIYTHVTKKMKSSVADIMENY"
     gene            complement(19144..19824)
                     /locus_tag="E9931_RS06530"
                     /old_locus_tag="SAMEA3919035_01273"
     CDS             complement(19144..19824)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990092.1"
                     /locus_tag="E9931_RS06530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_01273"
                     /product="hypothetical protein"
                     /protein_id="WP_002990092.1"
                     /transl_table=11
                     /translation="MKFWNLVVKTLKQKNNQAVAEKVVKITESTTNIKSPSYPDLNKYR
                     VNPSGKRYDDTYITGVGYKLREILLLVWWGRTKNPRKPTSKPPRYFFYDYHLNTKKTTD
                     MFIRDGLLKKNKEGCITLTLSGKVLYDEYKILWEIHSYKGYIGELPNMDRVFHGWNYNS
                     YKANNNLLEIRHLEDIVKYNTIMRDQYKKGSNEYNAFQQDIEQDKNQIALLFNEHQLLE
                     NIDN"
     gene            complement(19859..20617)
                     /locus_tag="E9931_RS06535"
                     /old_locus_tag="SAMEA3919035_01274"
     CDS             complement(19859..20617)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990090.1"
                     /locus_tag="E9931_RS06535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_01274"
                     /product="S24 family peptidase"
                     /protein_id="WP_032460392.1"
                     /transl_table=11
                     /translation="MNILGNSIKEIRKSKKMTQKELAKLTGFKQNTISNHENGNRQLDE
                     VDIRKYAKALKIEPQQLFDYSSSPTNPQVELIPSTLQKITSTSSQLEHKRQLNVLDYVE
                     TQLEQQNTVESNKDIVEEPQATYYTYNYYDHAASAGTGQYLNDVQVETIELPVDYDADF
                     VIPVHGDSMEPEYHSGDYVFVKLSVELTDGDIGVFEYYGDAYIKQLLINDEGAFLHSLN
                     SKYEDIPIDRDSDFRIIGEVVGSYSGNHSS"
ORIGIN
        1 agaacttgta agaacatgtg catgacgtca ggatgggctt tttccacctc atctaagaga
       61 ataagtgaat atggattgcg acgaacttgt tcggttagct gtccagcttc ttcatagccg
      121 acataacctg gaggagcccc gactaatttg gcgacagcgt gtttttccat gtattcggac
      181 atgtcaaagc gaatcatatt gtttgtcgaa ccaaagagtt caatggctag ttgtttagac
      241 aattcagttt taccaacccc agtcggtcca acgaataaga aagaaccaat agggcgattt
      301 ggagttccta atcccacacg gttacgacga atagccttag cgattttatc aacagcatcg
      361 tcttgcccga tcacgtgtgc tttcagatca ttggctaagt ttacgagttg agactgttcc
      421 ttttctttta agtccccaac tggaatatta gttttttgct ctacaatagc ttcaatggtt
      481 ttttcagtaa tgatgggaat atcttgctca tcgacttttt gagcctgcat ttctttgtat
      541 tttgtaattt gatcgcggaa ataagctgcg cgttcatagt cttcgtctcg agtagcttgc
      601 gccttgagat tctcagcttc aataagacgt ttgtcaattt ctttaggatc aacaaagttg
      661 agggttagat tcattttgga accagcttcg tccagaagat caatagcctt atcaggaaga
      721 aaacggtctt gaatatagcg gttaggtaaa tgagcggcag cttcaatagc ggctgggcta
      781 tatttgacat gatgatagtc ttcgtatttc ggttggatac cttttaaaat cgtgatggtt
      841 tcctcaacag aaggttcatc aactttaacg ggttgcatac gtcgttctaa ggcagcgtct
      901 ttttcaataa tacggtattc atttaatgta gtagcaccaa cgagttgcaa ctcaccacgg
      961 gccaaggctg gttttaaaat attaccagca tccatattgc cgtctcctgc agaaccagca
     1021 ccgacaatct catgaatttc atcaataaag agaatcacat ccttgcgatt gcgaatttct
     1081 tccattaatt tttgcatgcg ctcttcaaac tgaccacgga tacctgttcc ctgaacgagg
     1141 ctaaccacat caagacgaat cacttgcttg ccttggagtt tttgaggaac agtaccatca
     1201 ataatttttt gagccaaacc ttctacaaca gcagttttac caactccagg ctcaccaatt
     1261 agcacaggat tatttttagt acggcggttg aggatctcga taacgcgtgt aatctcttcg
     1321 tcacgaccaa taacaggatc aatattacca tttcttgcaa tatctgtgac attaatccca
     1381 aactcttcta ataagccctt tgcttgctga tttggtgttt gtggctgagc aggtcgttgt
     1441 ccattgtagt taccaccata gcgtcctccg ccatttccat tttgccctgc ctgagtaggt
     1501 ggggtatttg gaagattacc aaaagctcta aaattattca aatcaccaaa aaagtcatca
     1561 aagaaaggac ttgtggatct atcttgtgct ctatatcctg gggttaggcc atttaaaata
     1621 gaattggcag gatcggattt catgatttga taacaatttt gacagagatc aacctgtctt
     1681 tgttttccat taacacttgt ataaagatga atagtagatt cgtttaaatt acaattttga
     1741 cacagcataa tatacctccg agggtttatc taaaagtcaa agtcatttag tcaaaaatgg
     1801 tcaaacttta tattcatatt atagcaccac ggcttgggaa atcaagtaaa aagtttatcg
     1861 ctttagcgtt agcttttaga gagtaacatg acagagtaac tttattaagt ttccaatgag
     1921 caaatgttta aaatcattga aaagagtaaa aaaagtaaaa tatcaataaa tatattactt
     1981 tccttgttag tttcccttgt tttgtgttaa aataagaggg ataaaaaacg aataggagaa
     2041 acgaaatgga atcacatttg gtgagaatca tcaatcgttt ggagttgatg gtgacagatg
     2101 gcggtaatct caagcgaaat tttgaacgcg atggtgttgt tgttgcagaa gttgcctttt
     2161 caaatgatcc tgaaaatgga cctgttttca cattgcgtga tgttgaagcg cgtgagtcat
     2221 attcctttga tagcattgac ttgattgcaa tggaaatcta cgatttatta tattaagctt
     2281 gacatagtaa agagacttgc ctgaggcagg tttttttatt gtcaaaaagt attgtattaa
     2341 tattcatcag atggtataat tatctttatt ggaatgaacc taggacttat gaggagatat
     2401 aaatggattt gtcatttttg cccaaatact gggcctactt taactacggt gtacttgtca
     2461 ccattatgat ttcaatcagc gttgtctttt ttggaaccct tattggtgtc ttggtaaccc
     2521 tgattaagcg tagtcatgtg aagccgttga cctgggtcgt taatctttac gtttggatct
     2581 ttcggggaac acctatggtg gttcaaatca tgattgcctt tgcttggatg cattttaaca
     2641 atatgcctac tattggtttt ggggttttag acttggactt ttcaagacta cttcctggaa
     2701 ttattatcat ttcattgaat agcggtgctt atatttcaga aattgttaga gcaggtattg
     2761 aggctgtacc aaaagggcaa ttagaagcag cttattcact aggtattcgt cctcaaaatg
     2821 ccatgcgtta tgtgattttg cctcaggcct ttaaaaatat tttgccagcc ttaggaaatg
     2881 aatttattac cattattaag gatagtgctc ttttacaaac cattggagtg atggaacttt
     2941 ggaatggtgc ccaatcggtg gtaacggcta cttattctcc aatttcccct ttactggtgg
     3001 ctgcttttta ctacttaatg gtcacaacag tgatggcaca gttattggca gtcttagaac
     3061 gtcacatgtc gcaaggaggt aatcattgat gactgaggct attatttcaa ttaaagactt
     3121 gcacaagtat tatgggcaca atgaagtgct taagggaatt gatttagaca ttatgccagg
     3181 agaggttgtg gtgattattg gcccttctgg ttctggaaaa tcgaccttac ttcgaactat
     3241 gaatcttttg gaagtaccaa ctaagggaca gattaggttt gaggggattg atattaccga
     3301 taagaagaat gatattttca gcatgcgtga aaaaatggga atggttttcc agcagtttaa
     3361 cctctttccc aatatgacta ttttagaaaa tatcacttta tcgccaatca aaactaaggg
     3421 aatggctaaa gcagaggctg acaaaacagc cttgagcttg ttggacaaag ttggattatc
     3481 agaaaaagcc aaggcttatc ctgctagtct ttctggtggg caacagcagc ggattgcgat
     3541 tgcgcgtgga ctggctatgg atccagatgt tttactcttt gatgaaccaa cttcagctct
     3601 agacccagaa atggtgggtg aggtcttggc tgtcatgcaa gatttggcta aatctgggat
     3661 gactatggtt attgtgactc atgaaatggg ctttgctaaa gaagtcgcag atcgtgtgat
     3721 ttttatggat ggcggcgtta ttgtggaaga aggaagtcct aaccaacttt ttgatctgac
     3781 taaagaagaa cgtacaaaag attttttgag tagagtatta taaatctgtt ctatgaatta
     3841 taaaaggaag tcctaaatca tttaggactt ccttttataa tttgctaagg cattttatag
     3901 gagattactt ttctttttgt taaaataaaa agaaatagtt acattatttg catagaagaa
     3961 agggatctgt tatggtttca gtgatgtggt ttcgtagaga tttaaggatt gatgatcaaa
     4021 aagctttagc tcatgttatt gctagtcaat caccgacctt atgtgtgttt caatttaaca
     4081 aggagcaatt aaacctgcta catagtcgga atcaatctag ttttattact agcgttttgg
     4141 cttttagaaa gttattaaaa tgtgaaggta ttgacttata tctaatgtat ggagacttaa
     4201 tgacctgttt tgagcaatta ttgacacaat taaaagactg gacagatgtg tattttaact
     4261 atgatgaatc tggatatggt cgtttacgtg atcaaaaagc agcacaattt ttcaaaaaaa
     4321 atgggattgc cgttcatacc taccaagatc actatttaca tggtagtcaa gagatcatta
     4381 accaatcagg tcagccttat aaagttttta cgccctacta taggatttgg caaaattatc
     4441 cgaaagagac tcctattaaa gtagaactat cgcaaggcag gtggttaaac cttgagacac
     4501 cagatgatgt tttaaggact gttgagagct ttaaagatga aaaatatcag gatgttgcaa
     4561 cttttgatga agcgtcaaaa caactaaatc gatttattca agaccaatta gcagcttatc
     4621 acgctaatcg agattttcca gcacagctag ggacgagtcg gttgtctcct tttttaagaa
     4681 taggagctat tggcattcgc acggtatatc acgctgtgcg tcaagcacca aatagtctag
     4741 ggcaagctac tttttttaaa gaattagctt ggagagactt ttacaatatg gtctatgtgg
     4801 cttatcctga tcagaaaact cagcctatcc aaaaagcctt ttctcaaatc gaatgggtta
     4861 ataatcctga ctggtttcag ttgtggaaag aaggtaaaac gggttaccct attgttgatg
     4921 ctgcaatgct tcagttacaa aagacaggat ggatgcataa tcgtttacga atgatagtag
     4981 cttctttttt aactaaagat cttttatgtg attggcgttt aggagagcag tattttcaac
     5041 aacaactaat tgattatgat gctgccagta atatcggagg atggcagtgg gctgcttcca
     5101 ctggaacaga tgctgttcct tattttagaa tatttaatcc tgttactcaa ggtaagcgct
     5161 ttgatcccaa aggcgagttt attaaagcgt atttgcctca actagaacac gttccagaga
     5221 agtatctcca cgaaccgtgg aagatgccaa aaaaccttca agagagtgtg tcctgtatta
     5281 ttggcacaga ctatcctcaa ccaattgtcg atcatgctaa acaacgtgaa caagctattg
     5341 caaagtatga gtgggcaaaa gaaaaagcaa aaatagaatg actgttctca ttataagagt
     5401 ttaaacaaaa agttatcatg aattaagatt atttaattta aaaaataagt tgactttatt
     5461 tagattattt gatactattc agttgtctcc cttagagaaa gcgatttctt gttttggagc
     5521 tgatttttac catttggtct tagaatagga tgagtaatat gacttacaac gaggtatatc
     5581 aagaatggtt gcacaataat gatcttagtg atgatattaa agcagattta gcagccataa
     5641 aagacaatga ggctgagatt caagatcgtt tttacaaaac acttgaattt ggaacagcag
     5701 ggctaagagg aaaacttgga gcaggcacca atcgcatgaa tacctatatg gttggtaagg
     5761 cagcacaagc tttagctaat actattattg atcatggacc tgaagcagtt aaaaagggca
     5821 ttgcggttag ttatgatgtt cgctatcaat ctagaacatt tgcagaatta acatgctcta
     5881 ttatggcagc taacggtatt aaggcgcacc tttataaagg gattcggcca acaccaatgt
     5941 gttcgtacgc tattcgtgct ttgggatgta tctctggtgt tatgattacg gctagtcaca
     6001 atccccaagc ttacaatggt tataaagctt attggcaaga aggttctcaa attttggatg
     6061 acattgcgga tcaaattgca caacacatgg ctgcactaac tcagtatgaa gaaatcaaac
     6121 aaatgccttt tgaaaaggct ctggacagtg gacttgttac ttatattgat gagagtattg
     6181 aagaagcata taaaaaagaa gtgcttggtt taacgattaa tgatactgac attgataagt
     6241 cagtccgagt agtctatacc cctttaaatg gtgttgggaa tctaccagtg cgtgaggttt
     6301 taagacgccg cggttttgaa aatgtttatg tggtacctga gcaggaaatg cccgatcctg
     6361 attttacaac agttggctat cctaatcccg aagtccctaa aacttttgca tattcagaaa
     6421 aattaggtaa ggcagttgat gctgatattt tgattgcaac tgatccagat tgtgaccgtg
     6481 tggctttaga agttaaaaac gcagtcggtg actatgtttt tctcaatggc aataaaatcg
     6541 gagcgctttt atcttactat atcttttcac aacgatttga cttaggcaat ttaccggcta
     6601 atcctgtttt agtgaaatcc attgtaacag gagacttgtc acgggctatt gctagccatt
     6661 atggtattga aaccgttgaa acattgactg gttttaagaa tatttgtggc aaggcaaacg
     6721 aatatgatgt gacgaaacag aaaaactatc tgtttggtta tgaagaaagt attggttttt
     6781 gctatggcac ttttgttcgt gacaaagacg ctgttagcgc ctctatgatg attgtagaaa
     6841 tggcagctta ctacaagaaa aaggggcaga atttactaga tgttttgcag actatttatg
     6901 cgacatttgg gtattataat gaacgtcaaa ttgccttgga gcttgagggg atagaaggac
     6961 aaaaacgcat tgcgaggata atggaagatt tcagacagac accaatagct agtgttgcag
     7021 aaatggcgtt agacaagaca attgatttta ttgatggcta tcaagatttt ccaaagcaaa
     7081 actgtctcaa attttatttg gatgatggtt cttggtatgc acttagacca tcaggaacag
     7141 agcctaaaat aaaattttat ttatatacta ttggccaaac acaagaaaat agtgcaacaa
     7201 aattagatgc tattgaagca gcgtgtcgca caaaaataaa tcaggttaat taaacatcaa
     7261 aaatggataa cacttttaca ctatttttcc atataaacaa ctacaaaagg aggtgagact
     7321 tttaggcacc ttctttttct tgtaggtgcc actaatcaat ttaatcgact caaaccaata
     7381 ctaaaaaata agtaagagta taaagaacag gcatctattt ttttgttata atagaaaaat
     7441 gaaattaaag ggagatgtca atgacagaac taattgatgg taaagcctta gctcaaaaga
     7501 tgcagcaaga gttagcagct aaagtcaaca atctaaaaca aaaaaaagga attgtaccag
     7561 gcttagccgt tattcttgta ggtgatgatc ctgctagtca ggtgtatgtc cgtaataaag
     7621 agcgtgcagc tcttactgta ggttttaaaa gtgagaccgt tagattatca gaattcattt
     7681 gtcaagaaga gcttattgca gtaatcgaac gttacaatgc agataacact attcatggta
     7741 ttttagtgca gttacccctg ccaaatcata ttaatgataa aaaaattatt ctcgccattg
     7801 atcccaaaaa agatgtggat ggttttcacc cgatgaatac aggtcacctt tggtcaggac
     7861 gtcccttgat ggttccttgt actccatcag ggattatgga attgcttcga gaatataatg
     7921 ttaaccttga aggtaaacat gccgtcatta ttggcagatc gaatatcgtt ggaaaaccaa
     7981 tggcacagct cttactggac aaaaatgcaa cagtcacgtt gacacattca agaacacgtc
     8041 aattagaaga agtatgtcgc tgtgcagatg tgttgattgt ggcaatcgga caaggtcatt
     8101 tcataacaaa acaatatata aaagagggtg cgatagtgat tgatgtggga atgaaccgtg
     8161 atgataatgg caagctaatt ggagatgtgg cctttgatga ggtggcagaa gttgcagcga
     8221 aaatcacccc tgtaccagga ggtgtcggtc ctatgacgat tgctatgttg ctagagcaaa
     8281 cttatcaatc tgccctccgt agtactcata aatagttata attagacaat tcaacataag
     8341 agaatataag aagtcagcaa tggcttcctt ttttgttttt ctgctcacta tttatccaga
     8401 aaaatggtat aattgcatta gtatgcaaag ggactatgtc aggtccaact aagtgaaagg
     8461 tggcttgatg gcagattatt taaccgtcac tcatttgacg aaatatttaa aattaaaatt
     8521 tgaccgtgac ccttatttgg aacgggttta tctgactggt caagtgtcca attttcgaaa
     8581 acgaccaact catcaatatt tttctttaaa agatgaaagt gctgtgattc aagccaccat
     8641 gtgggcagga gtctataaaa aactaggatt cgacctagaa gaaggcatga aaattaatgt
     8701 aattgggcga gtccaacttt atgaacctag tggctcttac tctatcgtga ttgaaaaggc
     8761 agagccagat ggtataggtg ccttggcttt gcagtttgaa caattaaaga aaaaattaac
     8821 ggcagaaggt tattttgagc aaaaacacaa gcaggccttg ccacagtttg tatcaaaaat
     8881 tggggtcatt acaagtccta gtggtgctgt gattcgagat attatcacaa ccgtttcacg
     8941 gcgttttcca ggggttgaga ttttattatt cccaactaaa gtacaaggtg atggagccgc
     9001 ccaagaagta gtggctaata ttcgaagagc caatcaaaga gaggatttgg acttgctcat
     9061 tgtcggccgt ggaggtggct cgatagaaga cctttgggcc ttcaacgagg aaatagtggt
     9121 tcaggctatc tttgaatcgc aacttccagt gatttcgagt gtgggtcatg aaacagacac
     9181 gactttagcg gattttgtgg cagatcgcag agcagccaca ccaacagcag cagcagagtt
     9241 agcaacgcct attacaaaaa cagatcttat gtcttggata gtagagcggc aaaatcgttc
     9301 ctatcaggcc tgcttgaggc ggattaagca acggcgagag tgggtggata aactctcgca
     9361 atctgttatt tttaggcaac cagaacgatt atatgatgcc tacctgcaaa aaattgatcg
     9421 tcttagcatg accctgatga atacgatgaa agatcgtctg agttccgcca aagaaaacaa
     9481 ggttcagttg gaccatgcct tggccaatag tcaattacag acaaaaatcg agcgatacca
     9541 agaccgtgtt gctaccgcta agcgtttact gatggctaat atggctaggc aatatgatag
     9601 tcagctggct cgctttgaaa aagcacagga tgctttgcta tcactggatg tcagccgaat
     9661 tatcgcccgt ggttatgcaa tgattgaaaa aaatcaagca ctggtagcct ctgtaagtca
     9721 gataacaaag ggtgatcagt taaccattaa gatgcgtgat ggacaattag atgtagaggt
     9781 aaaagatgtc aaaaacgaaa acatttgaag aaaatttaca agatttagag actattgtga
     9841 acaaacttga aaatggggat gtccctttgg aagaagctat ttcagaattt caaaaaggaa
     9901 tgcttctctc aaaagaactt caaaagacct tacaagcggc agaaaaaaca ctcgtcaaag
     9961 tgatgcaagc tgatggcaca gaagtagata tggatgatta atggacaaat tagctagaat
    10021 tgacgaagcc attcgtcgct actataagac gactagtaac ggtgtatctg aagagttgat
    10081 tgatgctatc ttgtattctg ttgacagtgg tggcaagcgc attcgcccac ttatcttatt
    10141 agagatgatt gagggatttg gggtatcgtt acagaatgct cattttgatt tggctgcagc
    10201 ccttgaaatg attcatacag gaagtctgat tcacgatgat ttgccagcca tggataatga
    10261 tgattaccga cgtggtagac tgaccaatca caaacaattt ggagaggcta ctgctatttt
    10321 ggcgggagat agcttatttt tagacccctt tgggttaata gctcaagctg aattaaatag
    10381 cgaggttaaa gtagccttaa tccaagaact ttccctagct tcaggaactt ttggcatggt
    10441 tggtggtcag atgctagata tgaaagggga aaatcaagct ttgagtctct ctcagttgtc
    10501 actgattcac ctcaataaaa ccggaaaatt attaactttt ccttttaaag cagcagctct
    10561 tgtaacagaa caggctatta ctgttcgtca acaactagag caggcgggaa tgctcatcgg
    10621 gcacgccttt cagattaggg atgatatttt agacgtgaca gctagctttg aagatcttgg
    10681 aaaaacgcct aaaaaggatt tatttgcaga aaaagctact tacccaagtt tactggggtt
    10741 agaagcctcc taccaactgt tgacagagag tttagatcag gctttgacga tttttcagac
    10801 actcgaaagc gatgtcggct ttaagcctca aataattaca aaactgatag aagggttacg
    10861 acttaatgcc taaagaaaga gtagatgtgt tagcctataa gcaaggatta tttgagacca
    10921 gagagcaagc taagcgtggt gttatggcag gcttagtggt ctctgtgatt aatggccaac
    10981 gctatgacaa gccaggtgac aaaattgacg atgggactga gttaaaactt aaaggtgaaa
    11041 aactcaaata cgtcagtcgt ggtggattaa aactggaaaa ggggctgcac gtttttggtg
    11101 tatcggttgc taatcaaatt gggattgata ttggcgcttc aacaggtggt tttaccgatg
    11161 ttatgttaca agatggggcc aaactagtct atgccgtcga cgttgggact aaccagttgg
    11221 tatggaaact cagacaagat ccacgagtaa gaagtatgga acagtataac tttcgttatg
    11281 ctcagccaga ggactttaat gagggacagc ctgtatttgc cagtattgat gtgtccttta
    11341 tttctctcag cttgattttg ccagccctgc ataacgtttt gtcagatcag ggacaggtta
    11401 ttgctctcat taaaccgcaa tttgaagctg ggcgcgagca gattggtaaa aaaggcatcg
    11461 tcaaggacaa acagattcat gaaaaagtga ttcaaaaggt catggatttt gcctcaggtt
    11521 acggatttac agttaaggga cttgattttt cccctattca gggtggtcat ggcaatatcg
    11581 aatttttagc tcatcttgct aagtcacaga cacctgaaac gttagccccg catttggttc
    11641 aggaagttgt tgccaaggca cataaggagt ttgagaaaca tgaaaaagag tgaacgactt
    11701 gaattaatca aaaaaatggt tttgacgcat ccaattgaga cgcaacatga cctcttaaga
    11761 ttattggcag agcatgggtt agaattaacc caggctacta tttcaagaga catgaatgaa
    11821 attggtatag taaagattcc ttctggcagt ggacgttaca tctatggtct ttctcaagat
    11881 agtggaaaaa agatcgttca aggacctaga tcgataaaga gcactatttt agctgtatct
    11941 gacaaaacaa aaggtttaga acaacacctc tatttaaaag tcgtacctgg caatagtaaa
    12001 ttaatcaaac gttatttatt agcagatttt tcaaaagcta tttttagtct tattgctgat
    12061 gatgatagtt tactgttaat tgcaaagtct ccttcagaag cagatatgat acgccaagaa
    12121 attttgcttt ggatgcaggg tataacctag aaaaaaatag gggagaaagt gatgttatta
    12181 gaaatttcta ttaaaaattt tgctattatt gatgaaattt ccctaaattt tgaaaatggt
    12241 atgacggttt tgacgggtga aactggagca ggaaagtcta ttatcattga tgctatgaat
    12301 atgatgcttg gtgcgcgtgc tagtacagaa gtgattcgtc gtggagctaa taaagcagaa
    12361 attgaggggt tcttttcggt agatgctact ccagagctgg ttgcgtgtct ggaatcatca
    12421 ggtattgcta tggaagaaga actgattatt cgccgagata tctttgccaa tggcagaagc
    12481 gtgagccgca ttaatggtca gatggttaac ctagccacct taaaacaggt cggacagttt
    12541 ttggtagata ttcatgggca acatgaccaa gaagaattaa tgcgaccaca gctccaccag
    12601 caaattttgg acgcttttgg tgataaggct tttgagcaat tgaaagagaa ctatcagctt
    12661 atttttgatc gttataaaag cttgcgtcgc caggttattg acaaacaaaa aaatgaaaag
    12721 gaacacaaag atcgtattga tatgttggcc tttcagatag cagaaattga agctgctgcc
    12781 ttgagtcgag gtgaggacga ccggttaaat caagaacgtg atcgcttaat gaaccacaaa
    12841 caaattgctg ataccctgac caatgcctac gtcatgctag ataatgacga tttttcaagt
    12901 ctatccaata ttcgctctag catgaatgac ttactatcaa ttgagcagtt tgattcagag
    12961 tacaaaggga tgtcgacttc gatttctgaa gcctattata ttcttgaaga agtgagcaag
    13021 caattatcag ataccattga ccaactggat tttgatggtg ggcgattaca ggaaattgaa
    13081 tttcgcttgg atacactcaa tagcttaacc cgtaaatacg gtggtaatgt gaatgatgtg
    13141 cttgactact acgataatat tatcaaagaa taccagctat taacaggaga cgacttgtct
    13201 tcaggggatc tagaggcaga attgaaaagc ttggaaaaac aattggttgc tgctgcttcg
    13261 gagttaagtg tctctcgcca tcaattggcg gagcaattag aagctgagat taaagctgaa
    13321 cttaaggaac tttatatgga aaaagcagat ttcaaagttc actttaccac atcaaaattc
    13381 aatcgtgatg gtaatgaaag cttggaattt tacatctcta ctaatccagg cgaaggattc
    13441 aagccccttg tcaaggtggc ttctggagga gaattatcac gccttatgtt agccatcaag
    13501 gctgctattt ctagaaaaga agataagacg agtattgttt ttgatgaagt agatacaggt
    13561 gtttctggtc gcgttgcgca agccattgcc caaaaaattt ataaaattgg gcgacatggg
    13621 caagttctcg ctatttcaca cttacctcaa gttattgcta ttgctgatta tcagtatttt
    13681 atttctaaag aaagtaaaga agagtccacc gtttctaagg taaggttatt aactcctgaa
    13741 gaacgtgtgg aagaaattgc tagcatgatt gcaggaacag atatgacaca agctgctctt
    13801 acgcaggctc gtgaactact tgccaaacat taagattatg tttggtattt gatattttca
    13861 taattagatg acattgattt tttaggtgct aaaataatca ttgtgtcaga ccatttttcc
    13921 tctgttaatc tggcttggtt tgccttgaca aacctctgag aaatagtaga atagataaga
    13981 gaattttaag ctgaggggat agaaatgact agtaaaaaag cgtgtttatc aagcatcatt
    14041 gtgttagcaa gtttaacgtg tggaaatgat actgttagtg ccaatcatct ctcagcaact
    14101 ggagataagt ttgatgattg ctcaacactt gttgaaaaag atgtggcccc taaagatgaa
    14161 cttgagatgt tagcatggtc ctcgtctcaa acaactgatg atgctgacag agactatgaa
    14221 gattttctcg atgatgattc ttttaatgat gattctttta tttctcaaaa tgaaactgat
    14281 aagatgtttg agaatttaac tgatgatagg ttattagatg aattagatga agaagataca
    14341 attgagccag agcaaaatgt aataatgcct agtgacgatg agctatttga tttaactgat
    14401 gctgttgaga cacgccttac tgtttctagt gctccccatt tagaggctga attgccgaaa
    14461 ccacatttga ggagcctatc agatacagca ctgcggtctg gtgaaattag aggacattta
    14521 gataacaaac tggacgcttt gtctgtaaca gctacaaagt tagcattaac gatggctcaa
    14581 aaatttgatt tgacaacgca tgtctattct ataggtgaaa gctttagtga agtattagct
    14641 gctcattatg aagacagaaa agcagaatca gctttttcta agaaaaagag atttcacctt
    14701 cctattgcta ctccagatgt tgttatagag gagttaaggc gcctggtctc ttctattgga
    14761 agttcaaaag aagatgtttc agttccttat aatcggaagc taggtatggc agttgcaaaa
    14821 agaaaaatag ccctgccaca aacgggagag gagttctctt attatccagc tttacttggt
    14881 ttaatgatat taggattaac gccgattatg ataccaaaga agataaataa ttaggtaata
    14941 agttattgta gttgtaaaag acggggcaaa tgttcaagcg tgaaaaggtt gacttttgcc
    15001 tcgttttgta tctcgttatt gctaaggcat tttcttcgag cagctagtgc tcgccatacc
    15061 tatctaccga gtgactattc aatagcacta ccagttttgc tttatttagc aaggagtgtt
    15121 agaataaaga ggtgagaaac tagtttagaa tggaaaaata catgggaact ataaaaattg
    15181 ttacagattc atcaataact attgaaccag aattaattaa agctttagat attactgtag
    15241 tgcctttatc tgtcatgatt gatagcaaat tatattctga taatgattta aaagaagaag
    15301 gtcatttttt gagtcttatg aaggctagca aatcccttcc caaaaccagt cagccaccgg
    15361 ttggtctctt tgctgaaact tacgaaaatt tggtcaaaaa aggagtaact gacattgttg
    15421 ctattcacct ctcaccagct ttatcaggta ctattgaagc ttcccgtcag ggggctgaaa
    15481 tcgctgaggc acctgttaca gttttagatt caggatttac tgatcaagcc atgaaatttc
    15541 aggtcgttga ggcagcaaag atggcaaaag cgggtgctag tttgaatgag attttggctg
    15601 ctgttcaagc tatcaaatca aaaacagagc tctacattgg tgtatctacc ttagaaaatt
    15661 tagtaaaagg aggtcgtatt ggtcgtgtga cgggtgtttt gagctcgcta cttaatgtca
    15721 aagttgttat ggcacttaaa aatgatgagt taaaaacgct tgtcaaaggt cgaggtaata
    15781 aaacatttac gaaatggtta gatagttacc tcgctaaaaa tagtcatcgc ccgattgcag
    15841 agatagctat ttcttatgct ggtgaagcta gcctggcatt aaccttaaaa gaaagaatcg
    15901 cagcttatta caaccactct atttcggttt tagaaacagg ctctatcatc caaacacata
    15961 caggagaagg agcttttgcg gttatggttc gttatgaata atcgtcattt atttagtggg
    16021 atatttttct ttgttattag tttatgtctg gcctttttat tgctaaatat tattatccct
    16081 aagtcaaatt cacgtttgaa aaagagtgat tttctgaaaa aagaacaagt agctatccaa
    16141 tatgttgcta taggagattc attgacagaa ggagtaggtg atctaactca tcaaggtggt
    16201 tttgttcctt tgttaacgaa tgatctcagt gaatatttta aggctaatgt taatcatcaa
    16261 aattacggcg tatctggtga taccagtcaa cagattcttg ataggatgat aaaacaaaag
    16321 cagatacagt tatctttaaa aaaagcagat ataatgacgt taaccgttgg tggtaatgat
    16381 gttatggcag ttattcggaa gaatttagcg gatttgcaag tttctagttt tagaaagcca
    16441 gctcgtcagt atcaaaaacg attaagacag attatcgagt tagccagaaa agataataaa
    16501 gatcttccta tttttatttt aggcatctat aatccgtttt atttgaattt tccagaacta
    16561 actgatatgc aaaaagtgat tgatgactgg aatatcaaaa ctaaggaggt tgttggagaa
    16621 tacgatcgtg tgtactttgt gccaataaat gacctcttgt ataaagggat aaatggacaa
    16681 gaaggaattg tccattcttc aggagatcaa actacaattg tcaatgatgc cttgtttact
    16741 ggggaccatt ttcacccaaa taatactggc tatcaaatca tgtcaaatgc agtaatggag
    16801 aaaattaaaa agcatgaaaa aaaaatcaaa ccttaattgg tggaagtgga gcttcttatg
    16861 tctgcttgct tttaataccg cctttttgat ggttattgca agtcgtctca ttcaagtaag
    16921 agaacctgag tcagaactga ttgctaaaaa accagttaaa aatatcaaaa ttggtacatt
    16981 tgtcacaacc agagaacagc ttaacgaaac tgtagcaagt tatcttaaag attatcagac
    17041 taaaaaaatg tcttataaat tttatgcgac atcttcttct attttgtttg aaggaactta
    17101 tcaattatta gggtatgaag tccctttata tatctatttt caacctcatc gtctagaaaa
    17161 tggagctgtc caactacagg tgatctcttt ttcagtggga actctgccac tcccagaaaa
    17221 agatgttttg cagtatttga aatcaagcta caaattgcca agctttgtta aagtgatgcc
    17281 aaatcaatca gctatcgttg ttaatttaca agatatccaa aatgatgcta aggtttattt
    17341 aaaagccaag aaaattgatt tatttaatga tgaaatcagt tttaacatct ataagaaata
    17401 agctcaaata acgttaaata cttgacctaa tcgctttttt tagatatgat aatatctgtt
    17461 aaagcattaa gcttactaat tatttggagg atttgttaaa tggctaacaa acaagattta
    17521 atcgcaaagg ttgcagaagc aactgaattg actaaaaaag attcagcagc agcagttgat
    17581 gccgtgtttt ctacaatcga agctttcctt gctgaaggtg aaaaagtaca attgatcggt
    17641 tttggtaact tcgaagtacg cgaacgtgca gctcgtaaag gtcgtaaccc acaaactggt
    17701 gcagaaattg aaattgcagc ttcaaaagtt ccagccttca aagctggtaa agctcttaaa
    17761 gacgctgtta aataattgca tagataaaag cccattgcat caagcgttac agcctgtgca
    17821 gtgggctttt ttgtgttcag gggggtaaaa aaggggtaaa aaatttaata gttttccata
    17881 atatcagcta cacttgattt cattttcttt gtgacatgcg tataaatttg ggcagtagtt
    17941 ttagcgtctg catgtcctac acgttccatg attgatttta gcggcacgtt attctctgct
    18001 agacggctaa taagagtgtg acggaagatg tggctagtaa gtttttttgt aattgggtct
    18061 tccaatcttt cattagcttt ttttaaagct aagttgaatg agttagtctg aattggaaca
    18121 ccgttttttg ttgtaaaaag gtatcccata tctctatatc tatgatttgt atttttttct
    18181 agttcgttca taaattctaa ctcttgtaga atttcaagtt ctctacttgt catgatggtt
    18241 tcacgataag aagctaatgt ctttggtgct gtcttttccc cgttacgata tccttctgta
    18301 tgatcaaatg ttccgtgcaa ttgcaatatt cttgacttag attcgtagtt gcacggctca
    18361 atgctgacag cttcaccgat acgacaaccg ttcaaactga taaactcagc caacaaacca
    18421 agtcggtaag tgctaggtct tctgtacaat tctttcaata atggtttaat ttcatcttct
    18481 tcaagatatt tttcttcagc ctttttccag tcttcaagag ttttctttac ccttgggagt
    18541 ttagcacgtc ttgcaggatt atcttggata atatccaaac caacagcata atcaaatgct
    18601 aagtttagca tagacttatt acgctctttt ttattcctag agcaatctag gttatcgaga
    18661 taattctgaa cgtatttagg atcaatattc actactttaa cacctattcc aaaagtttcc
    18721 cttatctctt cgatgttacc cctcagagaa gctacagacg accttttaag ttctttctta
    18781 taaaacgccc accattcatc taaaagttcc gtgaaaagta actcagaggc ctttaattgc
    18841 gctatttttt ctgttatttt ttgttcaagg atttttcgag ctgctttata agctcttgaa
    18901 ttatccttct ccatagtaac ggatacaggt ttccatgttc cagtgtaagg atctttataa
    18961 ttttcacgaa atttgaattt accgttatca gtttcttcta tccacatttg ttttttacct
    19021 cattttctgt taaaataggt atagtaaaga gacctactgc gaagcaggtt tttactatac
    19081 tgtcttgcct cacgctcaga gtcgccaaac tttgagagcg tggggctttt tgttttagat
    19141 taactaatta tcgatatttt caagcaattg atgttcgttg aacaatagtg ctatctggtt
    19201 tttatcttgc tcaatatctt gttgaaacgc attatattca ttgctacctt ttttatattg
    19261 atctctcata attgtattgt attttacaat gtcttctaaa tgtctaatct ctaataaatt
    19321 gttattggcc ttataagagt tgtaattcca tccgtggaac actctatcca tgtttggtaa
    19381 ttcaccgata tatcctttat acgaatgtat ttcccagagg attttgtact catcgtaaag
    19441 aactttcccc gatagtgtta aagtaataca cccttcttta ttctttttaa gcaatccatc
    19501 tcgaataaac atatctgtag tttttttagt atttaaatga taatcgtaga agaagtagcg
    19561 tggtggttta cttgtcggtt ttctggggtt tttagtacgc ccccaccaca ccaacaataa
    19621 aatctcacgt agtttgtatc ctacacctgt tatgtatgta tcatcatatc ttttcccgct
    19681 tggatttact ctatacttat ttaagtcggg atagcttggt gactttatat tagtagtcga
    19741 ttcggtaatt tttacaacct tttcagctac agcctgatta tttttctgtt ttagagtttt
    19801 aactaccaaa ttccaaaact tcatatcaat ctcctaacct aaattcttta accatcactc
    19861 atgagctatg atttcccgaa taacttccaa cgacttcacc aataattcta aagtcgctat
    19921 ctctatctat cggtatatct tcatacttgc tatttaaact gtgcagaaat gccccctcgt
    19981 catttataag tagctgtttg atataagcgt caccatagta ttcaaagacg cctatatcgc
    20041 catctgtaag ctctacggat agcttaacga acacatagtc tccagagtga tactctggtt
    20101 ccatagaatc gccatgaacc ggtatgacaa aatcagcgtc ataatcgact ggtaattcaa
    20161 ttgtttctac ttgtacatca tttagatact gacctgtacc agctgaagct gcgtggtcgt
    20221 agtaattgta ggtgtagtag gtggcttgtg gttcttctac tatatcctta ttgctttcta
    20281 ctgtgttttg ttgttctaat tgtgtttcga cataatcaag aacgtttagt tgtcgcttgt
    20341 gttctaattg agaagaagta gaagtgattt tttgtagagt agatgggatg agttcaactt
    20401 gggggtttgt gggagaagag gaatagtcaa aaagctgttg tggctctatt ttcagtgctt
    20461 tagcatattt tcgaatatct acttcgtcaa gttgtctatt accattttcg tgattagaaa
    20521 ttgtattttg tttaaatcca gttagttttg ctaactcttt ttgggtcatt tttttggatt
    20581 ttcgaatttc tttgatagaa tttccgagaa tattcataat atttttcctt tctctactat
    20641 aaatataaca tcaagaaaca aaaaagtaaa taaaaaaatc tcaaaaagag ataagaaata
    20701 gttgacaaaa tatctcgttt tgagatataa tataatcaag cttaaggaat taagcaaagc
    20761 gaaaggaggt gggggaatga cgaaaaaaca acgtttaaaa caggaacatc tcaaacctaa
    20821 aaagcgttta agagaagaac gtttaaaacg tgaatacaca gaaatgtata tgg
//
