LOCUS       NZ_CAAHQE010000003     22835 bp    DNA     linear   CON 19-DEC-2024
DEFINITION  Streptococcus pyogenes strain Bel002, whole genome shotgun sequence.
ACCESSION   NZ_CAAHQE010000003
VERSION     NZ_CAAHQE010000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (03-APR-2019) WTSI, Pathogen Informatics, Wellcome Trust
            Sanger Institute, CB10 1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900985135.1-RS_2024_12_19
            Annotation Date                   :: 12/19/2024 10:09:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,745
            CDSs (total)                      :: 1,683
            Genes (coding)                    :: 1,623
            CDSs (with protein)               :: 1,623
            Genes (RNA)                       :: 62
            rRNAs                             :: 3, 4, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 3, 1 (16S, 23S)
            tRNAs                             :: 49
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 60
            CDSs (without protein)            :: 60
            Pseudo Genes (ambiguous residues) :: 0 of 60
            Pseudo Genes (frameshifted)       :: 28 of 60
            Pseudo Genes (incomplete)         :: 32 of 60
            Pseudo Genes (internal stop)      :: 14 of 60
            Pseudo Genes (multiple problems)  :: 11 of 60
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:22:44
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 223753
            Orig. end                         :: 246588
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CAAHQE010000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22835
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22835
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22835
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:12835](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12835
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     gene            complement(343..678)
                     /locus_tag="E9931_RS04895"
                     /old_locus_tag="SAMEA3919035_00958"
     CDS             complement(343..678)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003048651.1"
                     /locus_tag="E9931_RS04895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_00958"
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_002982731.1"
                     /transl_table=11
                     /translation="MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDI
                     EKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKDYIVLYHIEGEENRVVIDYLLPTQS
                     DYIKLFK"
     gene            complement(668..955)
                     /locus_tag="E9931_RS04900"
                     /old_locus_tag="SAMEA3919035_00959"
     CDS             complement(668..955)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000255538.1"
                     /locus_tag="E9931_RS04900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_00959"
                     /product="DNA-damage-inducible protein J"
                     /protein_id="WP_002988079.1"
                     /transl_table=11
                     /translation="MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVV
                     VTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQGKFYTSEEVRAELGL"
     misc_feature    1029..1047
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 23.24"
                     /tool="antismash"
     gene            complement(1605..2378)
                     /locus_tag="E9931_RS04905"
                     /old_locus_tag="SAMEA3919035_00960"
     CDS             complement(1605..2378)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004270277.1"
                     /locus_tag="E9931_RS04905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_00960"
                     /product="DeoR/GlpR family DNA-binding transcription
                     regulator"
                     /protein_id="WP_011285171.1"
                     /transl_table=11
                     /translation="MKKKERHEKILDILKVDGFIKVKDIIDEMNISDMTARRDLDTLAD
                     KGLLIRTHGGAQYLDYSSAKDEGHEKTHTEKKVLQTTEKKQIAQRAKNIIKDGETVFIG
                     PGTTLEHLAVELKNRNIRVITNSLPVFLILHPSTTIDLILIGGECREITGAFVGAIAIN
                     NLESLTFSKAFVSANAVYNNSIATYSDLEGEVQRVALNNAVEKILLVDSTKFESYDFYN
                     FYQLDQVDLIVTDKNVTTDIIEKYKKFSKIIIADK"
     misc_feature    2657..2670
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.23"
                     /tool="antismash"
     misc_feature    complement(2658..2671)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 24.03"
                     /tool="antismash"
     misc_feature    2823..2838
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: medium, score: 24.28"
                     /tool="antismash"
     gene            2824..3252
                     /gene="lacA"
                     /locus_tag="E9931_RS04910"
                     /old_locus_tag="SAMEA3919035_00961"
     CDS             2824..3252
                     /EC_number="5.3.1.26"
                     /codon_start=1
                     /gene="lacA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982747.1"
                     /locus_tag="E9931_RS04910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_00961"
                     /product="galactose-6-phosphate isomerase subunit LacA"
                     /protein_id="WP_136293820.1"
                     /transl_table=11
                     /translation="MAIIIGADKAGQELKEVIKDYLKEGKHEVVDVSENEVRDFVDTTL
                     AVAKEVNASEDNLGIVIDAYGVGSFMVATKIKEMVAAEVSDERSAYMTRGHNNARIITL
                     GSEISAPGIAKNIIKGFVEGKYDGGRHQVRVDMLNKMC"
     gene            3287..3784
                     /gene="lacB"
                     /locus_tag="E9931_RS04915"
                     /old_locus_tag="SAMEA3919035_00962"
     CDS             3287..3784
                     /EC_number="5.3.1.26"
                     /codon_start=1
                     /gene="lacB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012027025.1"
                     /locus_tag="E9931_RS04915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_00962"
                     /product="galactose-6-phosphate isomerase subunit LacB"
                     /protein_id="WP_136293821.1"
                     /transl_table=11
                     /translation="MKIAVGCDHIVTYEKIAVVDYLKSQGHKVIDCGTYDNVRTHYPIF
                     GKKVGEAELGVVICGTGVGITNAVNKVPGIRAALVRDMTSAIYSKEELNANVIGFGGKI
                     IGGLLMNDIIDAFLAAEYKPTEENKKWIEKMDSLQHASQDQNNPHFFDEFLEKWDRGEY
                     HD"
     misc_feature    complement(3306..3321)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.35"
                     /tool="antismash"
     gene            3830..4759
                     /locus_tag="E9931_RS04920"
                     /old_locus_tag="SAMEA3919035_00963"
     CDS             3830..4759
                     /EC_number="2.7.1.144"
                     /GO_function="GO:0009024 - tagatose-6-phosphate kinase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019512 - lactose catabolic process via
                     tagatose-6-phosphate [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1276: PfkB domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018379688.1"
                     /locus_tag="E9931_RS04920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_00963"
                     /product="tagatose-6-phosphate kinase"
                     /protein_id="WP_002988085.1"
                     /transl_table=11
                     /translation="MILTVTLNPAIDVSYPLDELKCDTVNRVVDVTKTPGGKGLNVSRV
                     LNDFGETVKATGCVGGESGDFIINHLPDSILSRFYKISGDTRTCIAILHEGNQTEILEK
                     GPLLSVDEIDGFTHQFKYLLNDVDVVTMSGSLPAGMPDDYYQKLIKIANLNGKKTVLDC
                     SGNALEAVLKGDSKPTVIKPNLEELSQLLGKEMTKDFEALKEVLQDELFEGIEWIIVSL
                     GADGVFAKHKDTFYNVDIPKIKIVSAVGSGDSTVAGIASGLANDEDDRALLTKANVLGM
                     LNAQEKTTGHVNMANYDKLYQSIKVKEV"
     gene            4763..5744
                     /gene="lacD"
                     /locus_tag="E9931_RS04925"
                     /pseudo=""
     CDS             4763..5744
                     /GO_function="GO:0009025 - tagatose-bisphosphate aldolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019512 - lactose catabolic process via
                     tagatose-6-phosphate [Evidence IEA]"
                     /codon_start=1
                     /gene="lacD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017768297.1"
                     /locus_tag="E9931_RS04925"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="tagatose-bisphosphate aldolase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTITLTENKRKSMEKLSIDGVISALAFDQRGALKRMMAQHQTKEP
                     TVEQIEELKSLVSEELTPFASSILLDPEYGLPASRVRSEEVGLLLAYEKTGYDATTTSR
                     LPDCLDVWSAKRIKEAGAEAVKFLLYYDIDGDQDINEQKKAYIERIGSECRAEDIPFYL
                     EILTYDEKISDNASPEFAKVKAHKE"
     gene            5768..6085
                     /locus_tag="E9931_RS04930"
                     /old_locus_tag="SAMEA3919035_00966"
     CDS             5768..6085
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730102.1"
                     /locus_tag="E9931_RS04930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_00966"
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="WP_002982760.1"
                     /transl_table=11
                     /translation="MNREETTLLGFEIVAYAGDARSKFLEALKAAQEGDYAKAEELIAA
                     GSDCLNDAHNAQTSLLQKEAAGDDLAYSVTLMHGQDHLMTTILLQDLMKHMIELYKRGA
                     K"
     gene            6085..7782
                     /locus_tag="E9931_RS04935"
                     /old_locus_tag="SAMEA3919035_00967"
     CDS             6085..7782
                     /EC_number="2.7.1.207"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_component="GO:0019197 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase complex [Evidence IEA]"
                     /GO_function="GO:0015155 - lactose transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285167.1"
                     /locus_tag="E9931_RS04935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_00967"
                     /product="lactose-specific PTS transporter subunit EIIC"
                     /protein_id="WP_136293822.1"
                     /transl_table=11
                     /translation="MNGLIAQIEKGKPFFEKISRNIYLRAIRDGFIAGMPVILFSSIFI
                     LIAYVPNAWGFHWSKDIENLLMTPYNYSMGILGLFVAGTTAKALTDSMNRSLPSTNQIN
                     FMSTMLAAIVGFLLMAANPAKEGGFLTEFMGTKGLLTAFIAAFITVNVYKTCVKNNVTI
                     RMPEEVPPNISQVFKDLIPFTLSVVLLYVIELIVHTTLGVNVAESIGKLLAPLFQAADG
                     YVGITIIFGAFAFFWFVGIHGPSIVEPAIAAITYANAETNLQLLQAGEHADKILTSGTQ
                     MFIVTMGGTGATLVVPFMFMWLTKSKRNKAIGRASVVPTFFGVNEPILFGAPLVLNPIF
                     FIPFILAPIVNVWIFKFFIDTLGMNSFTANLPWTTPAPLGLILGTNFQVLAFILAALLI
                     VVNVIIYYPFLKIYDEQILAEEAAGTNSSDALKEKVAANFDTKKADAILEKSAAKETKE
                     ITDQTNVLVLCAGGGTSGLLANALNKAAKEYGAPVTAAAGSYGAHREILPQYQLVILAP
                     QVASNYEDMKVETDKLDIKLAKTEGAQYIKLTRDGQGALDFVKEQMEK"
     gene            7855..9261
                     /gene="lacG"
                     /locus_tag="E9931_RS04940"
                     /old_locus_tag="SAMEA3919035_00968"
     CDS             7855..9261
                     /EC_number="3.2.1.85"
                     /GO_function="GO:0033920 - 6-phospho-beta-galactosidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019512 - lactose catabolic process via
                     tagatose-6-phosphate [Evidence IEA]"
                     /codon_start=1
                     /gene="lacG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002290548.1"
                     /locus_tag="E9931_RS04940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_00968"
                     /product="6-phospho-beta-galactosidase"
                     /protein_id="WP_136293823.1"
                     /transl_table=11
                     /translation="MTKTLPKDFIFGGATAAYQAEGATHTDGKGPVAWDKYLEDNYWYT
                     AEPASDFYNRYPVDLKLSEEFGVNGIRISIAWSRIFPTGKGEVNPKGVEYYHNLFAECH
                     KRHVEPFVTLHHFDTPEALHSDGDFLNRENIEHFVNYAEFCFKEFSEVNYWTTFNEIGP
                     IGDGQYLVGKFPPGIQYDLAKVFQSHHNMMVSHARAVKLFKDSGYSGEIGVVHALPTKY
                     PFDANNLDDVRAAELEDIIHNKFILDATYLGKYSDKTMEGVNHILEVNGGELDLREEDF
                     TALDAAKDLNDFLGINYYMSDWMQAFGGETEIIHNGKGEKGSSKYQIKGVGRRKAPVDV
                     PKTDWDWIIFPQGLYDQIMRVKADYPNYKKIYITENGLGYKDEFVDNTVYDDGRIDYVK
                     KHLEVISDAISDGANVKGYFMWSLMDVFSWSNGYEKRYGLFYVDFETQERYPKKSAYWY
                     KKVAETQVIE"
     gene            9764..9919
                     /locus_tag="E9931_RS04945"
                     /old_locus_tag="SAMEA3919035_00969"
     CDS             9764..9919
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) lacticin_mat"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982773.1"
                     /locus_tag="E9931_RS04945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_00969"
                     /product="type A2 lanthipeptide"
                     /protein_id="WP_002982773.1"
                     /sec_met_domain="L_biotic_A (E-value: 9.8e-20, bitscore:
                     64.1, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="lacticin_mat (E-value: 7.3e-07, bitscore:
                     23.0, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFMKNSKDILTNAIEEVSEKELMEVAGGKKGSGWFATITDDCPN
                     SVFVCC"
     CDS_motif       9764..9850
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSFMKNSKDILTNAIEEVSEKELMEVAGG"
                     /locus_tag="E9931_RS04945_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9851..9919
                     /prepeptide="core"
                     /locus_tag="E9931_RS04945_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="4.40"
                     /molecular_weight="2306.6"
                     /monoisotopic_mass="2305.1"
                     /core_sequence="KKGSGWFATITDDCPNSVFVCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSFMKNSKDILTNAIEEVSEKELMEVAGG"
                     /leader_location="[9763:9850](+)"
                     /alternative_weights="2324.6"
     gene            10001..12835
                     /locus_tag="E9931_RS04950"
                     /old_locus_tag="SAMEA3919035_00970"
     CDS             10001..12835
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032491806.1"
                     /locus_tag="E9931_RS04950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_00970"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_115368426.1"
                     /sec_met_domain="DUF4135 (E-value: 2e-83, bitscore: 274.5,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.8e-80, bitscore:
                     263.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKRNELKLEYQQHQFYEYFNSIFDYDILDTSISENIYLLREKTH
                     KLFYSEFENQLFETIMFLSMKTLVLDINHFSKEIENKSKAYEQYIQQIREENGISNFFD
                     RYPYLLKQINREVGLVVESYSLLFDRFLKDLSEIRSCFNITESLSNVEFSLGDSHSQKQ
                     TVVKIEFKGKSVYYKPKSYDSYNILLELISLLKSNNIPSFSLPESLIKADYCWQLGVAY
                     TSSNKDEVAKIYFKYGVLAAFSEIFSITDLHMENVIVSGGDLYLIDVETFFQRKLNVQN
                     QNFEGITVDTYQRIYKTSLSNGLFPVQFEKNSAPNVSGISGKGGKRKKGKYELINKNRG
                     DMKLVKTDYFQEDGYNIPTLNGKVVEPLDYANEVIAGFRECYTFLMSQRAKVKKILEDF
                     PKLKTRAIFRNTSDYGKFLQASTNPKYLFSEKKRENLFSILHESKHIEQFIVVSEIKDL
                     MNGDIPYFSMDTSGNVYNSLGTVIGNLGETTSLFDNIATLNDERMKFTCELLGIVLKKP
                     IKHWEREKGKSYQFLSISSEHNFSEEILDSIRRIFIDADKNSFSSEEEITWLNIDITET
                     EQWVISPQNITLYNGLIGNALGYLYAYQILGEEQYLVSLNKILKTLETTKNLIETSDMS
                     VFLGKGGLIYLYFSLWKRLKLPQYQKLYLDIIKEFSSQSLEEQNIDYISGVSGLLVVLC
                     NIYNVEQNKTVYHLINRISEFIIDNVKKEDDKVYWVSDFSDSEILNGLSHGQSGIAYAL
                     LLSWKINKNYNYFKIAKSAIDFENTRISDGNWIDFRNKGKRSELGMPEPIYWCHGATGI
                     GLTRYRESKWLNDKELKNNYEMAKQTVLNNGYLNSDCLCHGKMGNMELFMNLDDSLKNE
                     VDIEGIILNIVRNSQKFGWESGLPQHTRVFNMMVGEIGIAYQLLRYISNYEVPSLLLLD
                     VPKGSIENEKDYTD"
     gene            12813..13454
                     /locus_tag="E9931_RS04955"
                     /old_locus_tag="SAMEA3919035_00971"
     CDS             12813..13454
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635704.1"
                     /locus_tag="E9931_RS04955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_00971"
                     /product="cysteine peptidase family C39 domain-containing
                     protein"
                     /protein_id="WP_136293824.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 3.2e-24, bitscore:
                     79.1, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKITPIEQTTPTECGLCCLYMMLDYFDIPETYFKLKQQVNLGRN
                     GLSIKNISDIASIYGVTCKTYRFSKYPENLPVMVFVSDSHFVILEDIRDDAFTIVDPAV
                     GKYVLAKNEFFELSPKFYTEFFYDKATNSSKKIAKRGLVGRNVKEMIFVNRKDTFLTIL
                     YTLIFQIITVSIPFFIRGIIDGNWVFLKKFGYLESAVLLSIIIFFREDFI"
     gene            <13432..14565
                     /locus_tag="E9931_RS04960"
                     /pseudo=""
     CDS             <13432..14565
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000619317.1"
                     /locus_tag="E9931_RS04960"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="FSGRILFNFLFLMVFTILHLYPLLVIVLYYRSFRQQISVVRRSLI
                     LFSLLLLVILGSELYGEMLDVNQAFNNLGWYLFPLIMSVIYYFKTIHDKLSFVTQRWLG
                     DYKARIELLFLLLILCWVVLIKVLVKEFLLFFIIVDASTLFCLVVISCIFYYLENSKQN
                     FDYENRRLNYFMKSEENMRVEFSNYLHDDVLQNIIAIKNSLSLENSNITHGFIVNELND
                     LVSGIREEIDTYHPIVPANQTMKENIQSLFDDIVKSRKSNTLLYFNCSDNMVVPSPYGD
                     IVYRFIKELINNAIKYGDGKDIRLSLTIQSDIIIIEESNQVVEKVHSISYGRGLKSFQE
                     TLAAFDGDLELQMDTKQFTIRILLPIDWKLCYEDFIN"
     gene            14546..15151
                     /locus_tag="E9931_RS04965"
                     /old_locus_tag="SAMEA3919035_00973"
     CDS             14546..15151
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057302.1"
                     /locus_tag="E9931_RS04965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_00973"
                     /product="response regulator transcription factor"
                     /protein_id="WP_002982799.1"
                     /transl_table=11
                     /translation="MKILLIDDHRLFAKSIQLLFQQYDEVDVIDTITSHFNDVTIDLSK
                     YDIILLDINLTNISKENGLEIAKELIQSTPHLKVVMLTGYVKSIYRERAKKVGAYGFVD
                     KNIDPKQLISILKKVDSGKKYFEQIESQDYVESLTDQEIAILNLSKKGFSIKEIEETLQ
                     ISRRTVFNHLTHIYSKLLVNNKQEAIYKAEQLGYFMDF"
     gene            15293..15493
                     /locus_tag="E9931_RS09255"
                     /old_locus_tag="SAMEA3919035_00974"
     CDS             15293..15493
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002988115.1"
                     /locus_tag="E9931_RS09255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_00974"
                     /product="hypothetical protein"
                     /protein_id="WP_011018219.1"
                     /transl_table=11
                     /translation="MPDMKSFLNLVKQKLFKPGLKKLVKLHNSQNVNICLYINDWNYFM
                     VRTMVFVEGSKVVLKISLNRV"
     gene            complement(15703..17283)
                     /locus_tag="E9931_RS04975"
                     /old_locus_tag="SAMEA3919035_00975"
     CDS             complement(15703..17283)
                     /EC_number="2.1.1.72"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0009007 - site-specific
                     DNA-methyltransferase (adenine-specific) activity [Evidence
                     IEA]"
                     /GO_process="GO:0009307 - DNA restriction-modification
                     system [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982804.1"
                     /locus_tag="E9931_RS04975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_00975"
                     /product="type I restriction-modification system subunit M"
                     /protein_id="WP_014407840.1"
                     /transl_table=11
                     /translation="MAEKTTSLRQALWHSADQLRGQMDANDYKNYLLGLIFYKHLSDKL
                     LLAVCDNLEKHFNTFTEAQKIFEDAYQDEGLKDDLISVVTGDLGYFIEPTLTFEKLIQD
                     VYHNTFQLESLAQGFRDIEQSGEDFENLFEDIDLYSKKLGSTPQKQNQTISNVMKTLNE
                     IDFEAVDGDTLGDAYEYLIGEFASESGKKAGEFYTPQAVSHLMTQIVFLGREDQKGMTL
                     YDPAMGSGSLLLNAKKYSNQSDTVSYYGQEINTSTYNLARMNMMLHGVAIENQHLSNAD
                     TLDADWPTDEPTNFDGVLMNPPYSLKWSATAGFLTDPRFSSYGVLAPKSKADFAFLLHG
                     FYHLKNTGTMAIVLPHGVLFRGAAEGKIRQKLLEQGAIDTIIGLPSNIFYNTSIPTTII
                     ILKKNRTNKDVFFIDASKEFDKGKNQNTMTDSHIKKILDAYKSRDNSDKFSYLASFDEI
                     IENDYNLNIPRYVDTFEEVPVKPLPELAKQLSDIDQEIAKTNAKLDQLMKQLVGTTKEA
                     QDELDTFRN"
     gene            complement(17296..18471)
                     /locus_tag="E9931_RS04980"
                     /old_locus_tag="SAMEA3919035_00976"
     CDS             complement(17296..18471)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054993.1"
                     /locus_tag="E9931_RS04980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_00976"
                     /product="restriction endonuclease subunit S"
                     /protein_id="WP_011054993.1"
                     /transl_table=11
                     /translation="MTKSKQPQYRFDGFEGEWEEKELGDIVQITMGQSPSSQNYTTNPS
                     DYILVQGNADIKNGYVFPRVWTTQITKQADKGDIILSVRAPVGDVGKTNYHVIIGRGVA
                     AIKGNEFIFQILKYLKEIGYWKRISTGSTFDSISSSNIKYAKIQIPSLPEQEAIGELFQ
                     TVDQLIQLQDQKLATLKEQKQTFLRKMFPAQGQKVPEIRLQGFDGEWEEKKLGEISRMF
                     SGGTPSVGISEYYNGNIPFIRSSEINSDQTELFITNKGLSNSSAKIVEKNTLLYALYGA
                     TSGEVGLSRISGAINQAILAIIPEKKYSSLFIKNWLYKQKSSIIEKYLQGGQGNLSGSI
                     VKGLELYLPSLPEQEAIGDFFQTLDQQMSQIEDKLTELKALKQTLLNRLFV"
     gene            complement(18484..21462)
                     /locus_tag="E9931_RS04985"
                     /old_locus_tag="SAMEA3919035_00977"
     CDS             complement(18484..21462)
                     /EC_number="3.1.21.3"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004386 - helicase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0009035 - type I site-specific
                     deoxyribonuclease activity [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054992.1"
                     /locus_tag="E9931_RS04985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919035_00977"
                     /product="type I restriction endonuclease subunit R"
                     /protein_id="WP_136293825.1"
                     /transl_table=11
                     /translation="MGNQTKTELELEKELIHLLETGESQWTYRKELKTEDALWDNFFKI
                     LAQNNTQYLNEEPLTASEKEQIKNQLNFVNYYEAAKWLAGENGIAKVQVQREDAKLGTI
                     RLEVVKADNVAGGTSVYEIANQVAFSGSRDRRGDVTLLINGLPMIQIELKSQNHQCIEA
                     FNQVKKYDKEGQFRGIFSTLQMFVVSNKTDTRYIAAAKENKLNPNFLTQWVDQNNKPQK
                     DLFAFAKEVLSIPRAHQMVMTYSVIDDDKKALILLRPYQIHAIEAVAEASRHRKSGYIW
                     HTTGSGKTLTSYKVARNILQIPAVEKSIFVIDRKDLDNQTASAFQSYAQNDIFDVDETE
                     DTRQLIKNLESSDRRVVVTTIQKLNAMISQMESYDTPKFKKLKERLAHLNVVFVVDECH
                     RAVTPERQRYLTNTFRNSRWYGFTGTPIFVENKRAQLGDLAQTTEQQYGKCLHQYTVKE
                     AIHDKAVLGFQVEYKTTIPDMPEDSIPEEAYDHEEHMLAVLDSIINQSSKKLGFNNGIG
                     QTFEGLLTVKSIARAQAYYDLMKKVKAGETDLVISKKVKEKLPDFPKVAITYSITENDN
                     ASISRQDKMTKNLEDYNHLFGTNFTIDNLQGYNRDLNDRLARKKDKFKDRHEQLDLVIV
                     VDRLLTGFDAPCLSTIFIDRQPMKPQHIIQAFSRTNRIFESRKHYGQVVTFQTPLRFKE
                     AVDKALSLYSNGGENDVLAPSWEEEKARFLENVTVLKNIVPDPDAFPTIESAQTAFLKQ
                     YAKAFQAFDKLFASVQVYSDFNETLLSEVGLSDEVIDTYKGTYQNVIAEIRKRREDDEA
                     IPEINIDYELESVQMDDINYHYILTLIQAFVDQEQEALQERLNDNPMDQYIQDLAKSNP
                     AMADSLAELWQDIQKEPKAYEGKSIAYELDNLIGDKIQRAIKYFADQWKADPDKLAFVA
                     TNYHSANSTKQVGMSTLKESLDYQAYKEKQGDSAMNKLKYKSQFERELVQFIRDQIQPL
                     KGH"
     misc_feature    21592..21612
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 26.6"
                     /tool="antismash"
ORIGIN
        1 atgaatttct agcagtctaa aggggaggtt ttgttaatgg gcaattctcc catgactggc
       61 agaatgtgaa gtcgaaacag atcaagagta cgagaagccg tggttggctc taccgtatct
      121 tgataggctt gataccattt ctcgaatatc tcgctataag ttttatgagt tggcttggtg
      181 aactcctcca agtttcctga agccttaagg tagattagcc tagcttcgta gtctttggct
      241 tctttgtgga atatctacta aacagcccga actcattttg ctcctagtta attggtaatc
      301 taccaaaaaa gccctagcaa gactgctaag gcttttaacg tgttatttga ataactttat
      361 atagtcgctt tgagtaggaa gcaagtaatc aataacgacc ctattttctt ccccctcgat
      421 atggtatagg acaatataat ctttacttaa ggtataacct ttagtgctgt gataatgact
      481 gatttttgaa ccatattttt catcggcatc aaaaccaact tctgggaaaa cctcgagttt
      541 ttctatgtcg ctaatgattt gctccatttt acgctgacct gatgttgagg agtagttttg
      601 agaaatataa tcacgaattt cttttagctt ctctaaaaca tcaggagcat agataatctg
      661 atatttctta tagtccaagt tcagccctca cttcttcaga ggtataaaac ttcccttgac
      721 gaacatcctc aatatttttg ttgatttcag cttgaaattg cttgaaaagt ttttctttct
      781 ctaactcctc ttccgtcaat aagtcaacct cgtttgtgac aacgacattt tgtaggaata
      841 atcttaaagc agatgataag gttaaatttt ttttgtttaa tactgtcatt gcttcgctta
      901 ccaattcttt attagcttga aaggtaaccg ctctgttttt ttttactgta gtcattttat
      961 gtaacctctt tatgtaattt atttaattat atcatatata caaaaaagtc aataaaaaag
     1021 actcggtaat tgagacagat tttcattatt tgataagctc cgaaacttat ttttgatacc
     1081 gtttaggttt aaatatttgt ctataaataa gatttttagt gatttttcat tttagaaaca
     1141 ttgattttaa agggatttga ctttaaataa tggagtgaac caaaaaccag gtcttaaaaa
     1201 agctcgtaaa gcttcacaat tctcaaaacg ttaatatact gttatatcag cgttttaaag
     1261 cgctttgaag acacctctta agtagacatg gtaacgaacc aaaatctact taagaggtat
     1321 gttgatgtct aaaagaaagc ttcactccat acgataaaga acaagcatgt cttgatgaca
     1381 gtaatggcaa ccattctaga ggtgaaatat atagctgtct gcctatttcc acgttattca
     1441 tcagaaaaag gaacagtaca agactgataa gtctgaaaaa aaccagaaaa taagttagca
     1501 agaaacttct ttataataca aacactactt tcagatatgc tccctgttta cttgacaggg
     1561 gatatatcta aaccctgaag tgctttttaa tatgagtagg tcctttactt gtcagcgatt
     1621 atgatttttg agaatttctt gtacttttct atgatatcag ttgtcacatt tttatcagtc
     1681 acaattaagt ccacttgatc tagttggtag aaattataga agtcataact ttcaaacttg
     1741 gtactatcaa ctagaaggat tttctcaaca gcattattca atgcaaccct ttgaacttct
     1801 ccttcgaggt cactgtacgt tgcaatagaa ttattataaa cagcatttgc gctaacaaaa
     1861 gcctttgaaa aagttagtga ttctagatta ttaatggcaa tagcaccaac aaaagctcca
     1921 gtaatttcac gacattcacc accaattaaa atcaaatcaa tagtagtgct cgggtgcaaa
     1981 attaaaaaaa caggaaggct atttgtaata actctgatat ttctattttt taattcgaca
     2041 gctagatgct ctaatgttgt ccctggacct ataaagacag tttcgccatc tttaataatg
     2101 tttttagctc tttgtgcaat ttgttttttt tcggtagtct gtaagacctt cttttcagtg
     2161 tgtgttttct cgtgaccttc gtcctttgct gaagaataat ccaaatattg agcaccacca
     2221 tgggtcctga taagtaatcc tttatctgcc aatgtatcga gatctcgtct agcggtcata
     2281 tctgagatgt tcatttcatc aataatatct tttactttta taaaaccgtc aacttttaag
     2341 atatcgagaa ttttttcatg acgctctttc tttttcattc ttatctccta tcagtgtctt
     2401 agggtataac tattaaaggt atcataacat aatatcaata aaaaaatcaa acaaaacaaa
     2461 cataaacatt ggaaaaaaca aaaattaaca aaatagaaaa tgttttaaat aaaacgttta
     2521 caataaatag agataagggt ttcgtaatat atgataggtt acgagtggct gtcaaaggga
     2581 tttatgaaat gaaaaagaaa cacaagaaac attaggataa taacgtaaaa atgaaaaaat
     2641 aaacattttt ttgtttattt ttataaaaaa taaacaaaaa aatgttgact tttatgtttg
     2701 gtgggtgtat gattaggtca tagaaataat gaaagcgtta tttcaaaaga tgttgcaaat
     2761 cgttaattaa ctatctacgt aggttttcca cattcactta ttctaaatca taggagaaat
     2821 aaaatggcaa ttattatcgg tgctgacaaa gcaggtcaag aacttaaaga agttatcaaa
     2881 gattacctta aagaaggtaa acacgaagtc gttgatgtta gtgaaaacga agtacgtgac
     2941 tttgtagata caactttagc cgttgcaaaa gaagttaatg catccgaaga taacttaggt
     3001 attgtcattg atgcatatgg tgttggttct ttcatggtag ctactaaaat caaagaaatg
     3061 gtggcagctg aagtatcaga tgagcgttca gcatacatga caagaggaca caacaatgct
     3121 cgaatcatca cgcttggttc tgaaattagt gctccaggaa ttgcaaagaa cattatcaaa
     3181 ggctttgtcg aaggtaaata tgatggtgga cgtcatcaag ttcgtgtcga catgcttaat
     3241 aaaatgtgct aattgattga aataggttaa aacaaggaga acaaaaatga aaattgctgt
     3301 aggttgtgac catattgtta cttatgaaaa aatcgctgtt gtggattacc taaaatcaca
     3361 aggtcataaa gttattgatt gtggtacgta tgataatgtt cgcacacact atccaatttt
     3421 tggtaaaaaa gttggtgaag cagaactagg tgttgttatc tgtggtactg gtgttggtat
     3481 tacaaatgcc gtaaacaaag ttcccggtat tcgtgcagca ctcgttagag atatgacatc
     3541 tgctatctac tcaaaagaag agctaaacgc aaacgttatt ggttttggtg gaaaaatcat
     3601 cggtggttta ttgatgaatg atattatcga tgctttctta gccgcggaat acaaaccaac
     3661 tgaagaaaat aaaaaatgga ttgaaaaaat ggatagcttg caacatgcta gccaagatca
     3721 aaacaaccca cacttctttg atgaatttct agaaaaatgg gaccgtggtg aatatcacga
     3781 ctaatatttg aaagaattat gataaggata tatagaaaaa ggagctattg tgattttaac
     3841 agttacttta aatccagcta ttgacgtctc ctaccctttg gatgagctaa aatgcgatac
     3901 tgtcaatcga gttgtagacg ttacaaagac acccggtggt aaaggcttga atgtttcccg
     3961 agttctaaat gactttggtg agacagtcaa agctacaggt tgtgtaggtg gagaaagcgg
     4021 tgattttatc attaatcatc ttcctgattc gattttaagt cgcttctata aaatttcagg
     4081 tgatactaga acttgtatag ccattttaca cgaaggtaat caaacggaga ttttagaaaa
     4141 aggaccgctg ttaagtgtag atgaaattga tggatttact catcaattta agtatttact
     4201 gaatgatgtt gacgtagtga caatgtcagg cagtttgcct gctggtatgc cagatgatta
     4261 ctatcagaag ttaatcaaga ttgccaatct taatggtaag aaaacggttc tggattgttc
     4321 tggaaatgct ctagaagcag tattgaaagg tgatagtaaa ccaacagtta tcaagcctaa
     4381 tcttgaagaa ctttctcaac ttttaggtaa agaaatgaca aaagattttg aagccttaaa
     4441 agaagtctta caagatgaac tatttgaagg aattgaatgg ataatcgttt ctcttggtgc
     4501 tgatggtgta tttgcaaagc acaaggatac attttataac gttgacattc ctaaaatcaa
     4561 aattgtaagc gctgtaggtt caggggattc tacagtggca ggtattgctt caggtttagc
     4621 gaatgatgaa gatgatcgag ctttattaac aaaagcaaat gtcttaggga tgttaaatgc
     4681 gcaagaaaaa acaactgggc atgttaacat ggcaaattac gataagttat atcaatctat
     4741 taaagtcaaa gaggtataaa aaatgacaat tactttaact gaaaacaaac gtaaaagcat
     4801 ggaaaaacta agtatagatg gtgttatttc tgctttagct tttgaccaac gtggagctct
     4861 caaacgtatg atggctcaac atcaaacaaa agagccaaca gtagaacaaa ttgaagagct
     4921 taaaagttta gtttctgaag aactaacacc atttgcatca tcaattttac ttgatcctga
     4981 atatggcttg ccagcaagtc gtgttcgttc agaagaagta ggcttgttgt tggcatatga
     5041 gaaaacagga tacgatgcaa caacaactag tcgcttacct gattgcttag atgtttggtc
     5101 tgcaaaacgt attaaagaag ctggagcaga agcagttaaa ttccttcttt actatgatat
     5161 tgatggagat caagatatca acgagcagaa aaaagcttac attgaacgta ttggttctga
     5221 atgccgtgca gaagatattc cattctactt agaaattcta acttatgatg agaaaatctc
     5281 tgacaatgct agccctgagt ttgcaaaagt taaagctcat aaagaatgaa gcaatgaaag
     5341 tcttctcaga agaacgcttt ggtgttgacg tcttgaaagt cgaagttcca gtaaatatga
     5401 aatttgtaga aagctttgca gatggtgagg ttctctttac aaaagaagaa gcagctcaag
     5461 ctttccgtga ccaagaagct tctactgatt taccatatat ttacttgagt gcaggtgttt
     5521 ctgccaaatt gttccaagat actttggtgt ttgcagcaga atcaggtgct aaattcaacg
     5581 gtgtcttatg tggacgtgct acctgggcag gatctgtaaa agtctatatc gaagaaggac
     5641 cacaagcagc tcgtgaatgg ttgcgtacag aaggtttcaa aaatattgac gaattaaaca
     5701 aagtgctaga taaaactgca agtccttgga ctgaaaaaat gtaacattat tttcggagga
     5761 aactacaatg aatagagaag aaactactct tttaggtttt gaaatcgtag cctatgctgg
     5821 tgatgcccgt tcaaaatttt tggaagcgct taaagcagcg caagaagggg attatgctaa
     5881 agcagaagaa ttaatcgctg caggtagtga ctgcttgaat gatgctcaca atgctcagac
     5941 aagtctacta caaaaagaag cagctggaga tgacttagct tatagtgtca ctttaatgca
     6001 tggtcaagat catttaatga cgaccatttt attacaagat ttaatgaaac acatgattga
     6061 actttataag agaggagcaa aataatgaat ggattaattg ctcagattga gaaagggaaa
     6121 cctttcttcg agaaaatttc tcgaaacatc tatcttcgcg ctattcgtga tggttttatc
     6181 gctggtatgc cagttatctt gttttcaagt atctttatct tgattgccta tgttccaaat
     6241 gcatggggct tccattggag taaggatatt gagaatctct tgatgacgcc atacaactac
     6301 tcaatgggta ttttaggttt gtttgtggct ggtacgacag ccaaagcttt aactgactca
     6361 atgaatcgat cattaccaag cacaaaccaa atcaacttca tgtctaccat gctcgctgct
     6421 attgtaggtt ttttacttat ggcagccaat ccagcaaaag aaggtggttt cttaactgaa
     6481 tttatgggaa caaaaggttt gttgacagcc ttcatcgcag cttttattac cgtaaatgtc
     6541 tataaaacct gtgtgaaaaa caatgttaca atccgtatgc cagaagaggt tccaccaaat
     6601 atctctcaag tatttaagga tttgattcca tttacgttat cagttgtact gctttatgtg
     6661 attgaattga ttgttcatac tactttaggc gttaacgttg cagaatcaat tggtaaactt
     6721 cttgcaccat tgttccaagc agcagatggc tatgttggaa tcactattat cttcggtgca
     6781 tttgctttct tctggtttgt tggtattcat ggaccatcta ttgttgaacc agccattgca
     6841 gcgattactt acgcaaatgc tgaaaccaac cttcaattac ttcaagctgg tgaacatgct
     6901 gacaagattt tgacttcagg gactcaaatg ttcatcgtta ccatgggtgg tactggtgca
     6961 actctcgtcg ttccattcat gttcatgtgg ttaacaaaat caaaacgtaa caaagccatt
     7021 ggacgtgcat cagttgttcc aacattcttt ggtgttaacg aacccatttt gtttggtgct
     7081 ccacttgttt tgaacccaat cttctttatt ccatttatct tggcaccaat tgtcaatgta
     7141 tggattttca aattcttcat tgacacactt ggaatgaaca gtttcactgc aaacttacct
     7201 tggacaacac cagctccatt gggtcttatc cttggtacaa acttccaagt gctagcattc
     7261 attttggcag ctttgttaat cgtagttaat gtcatcatct actacccatt cttgaaaatt
     7321 tatgatgagc aaattcttgc tgaagaagca gcaggtacga attcatcaga tgccctcaaa
     7381 gaaaaagtag cagcaaactt tgatactaaa aaagctgatg ctattcttga aaaatcagca
     7441 gctaaagaaa ccaaagaaat cactgatcaa actaatgttc tcgttctttg tgccggtggt
     7501 ggtacaagtg gtttgcttgc aaacgctttg aataaagcag ctaaagaata tggtgcacct
     7561 gtcactgcag cagcaggaag ttatggtgct caccgtgaga ttttaccaca atatcaactt
     7621 gttatccttg cacctcaagt agcttctaac tatgaagata tgaaagtgga aactgataaa
     7681 cttgatatta aattagctaa aacagaaggg gctcaataca tcaaattgac tcgcgatggt
     7741 caaggcgcat tagacttcgt taaagaacaa atggaaaaat aatatgtcgc tagggaaggt
     7801 tgggggtact caatcttcct ttatagtgaa atgaaaattt agaagaggta tatcatgact
     7861 aaaacattac ctaaagattt tatttttggt ggtgctacag ctgcttacca ggctgaaggc
     7921 gctacccaca cagatggtaa aggaccagta gcttgggata aatacttaga agacaactat
     7981 tggtacacag ctgagccagc aagtgatttt tataatcgtt accctgtcga tttgaaactt
     8041 agtgaagaat ttggtgttaa tgggatccgt atctctattg cctggtctcg tatttttcca
     8101 acaggaaaag gagaagttaa ccctaaagga gtagaatact accacaatct ttttgcagag
     8161 tgtcataagc gtcatgttga gccttttgtt acacttcacc attttgatac accagaagct
     8221 ctccactcgg atggtgattt cctcaatcgt gagaacattg aacattttgt aaattatgca
     8281 gaattttgtt ttaaagaatt ctcagaagtt aactattgga caacatttaa cgaaattgga
     8341 ccaattggcg atggtcaata cttagttggt aaattccctc caggtatcca atatgatctt
     8401 gctaaagttt tccaatcaca ccataacatg atggtctctc atgctcgtgc agtcaaactt
     8461 tttaaagata gtggttattc aggtgaaatc ggcgttgtcc atgctcttcc aactaagtat
     8521 ccatttgacg ctaacaatct tgatgatgtt agagcagctg aactggaaga tatcatccat
     8581 aataaattta ttcttgatgc aacttatcta ggtaagtatt cagataaaac aatggaaggt
     8641 gttaaccata tccttgaggt gaatggtggt gaacttgatc ttcgtgaaga agattttact
     8701 gcactagacg ccgcaaaaga tttgaatgac ttccttggta ttaactacta tatgagtgat
     8761 tggatgcaag cttttggtgg tgagactgaa atcattcaca atggtaaggg tgaaaaaggc
     8821 agctctaaat accaaatcaa gggtgttggt cgaagaaaag cacccgttga tgttccaaaa
     8881 acggactggg actggattat cttcccacaa ggtctatatg atcaaatcat gcgtgttaaa
     8941 gctgattatc ctaactacaa gaaaatttat atcactgaaa atggtcttgg ttacaaagat
     9001 gagtttgtag ataatactgt ttatgatgat ggacgtatcg attatgtgaa aaaacactta
     9061 gaagttattt ctgatgctat ttctgatggt gcaaatgtta aaggatactt tatgtggtca
     9121 ctgatggatg tcttttcatg gtcaaatggc tatgaaaaac gttacggtct cttctatgtc
     9181 gattttgaaa ctcaagaacg ttatcctaag aagagtgcct actggtataa aaaagtagca
     9241 gaaactcaag tgattgaatg attttgagat actgctttaa tacattttta cacgtcatgt
     9301 tcgtttactg aattatagtc acaaaaagta gatgatgttg acatttttca agcatagtat
     9361 tatttgctgt tgatggtaat ccattagttg taagatcggg ttataagtgt ttttagttga
     9421 tgaaaatggg ttttgaaagt tttatttaac atcctttttc agatatttga cttctgtcat
     9481 tcaaactcct gacctgatta aataagtaaa gtaaccattt tctgattaga gattgatgtt
     9541 ataacgagaa gcgattagat tgtaaaatag ctgtaaagaa cgagttttgt tttttatatc
     9601 agagggctat ttgttataaa gtgacctctt atgtgacatc tcaaaaatct tactaaaaaa
     9661 tatgaaaaaa gtcatttttg cactttttac tcattgaaaa tgaagacgta ttatttacaa
     9721 taaaagtgta gaaaatagtc actacatact gataggaagg agaatgagtt ttatgaaaaa
     9781 ttcaaaggat attttgacta atgctatcga agaagtttct gaaaaagaac ttatggaagt
     9841 agctggtggt aaaaaaggtt caggttggtt tgcaactatt actgatgact gtccgaactc
     9901 agtatttgtt tgttgttaat taaaacaatc tggataagca gactaaaatt tcctgtttag
     9961 acttagtcta ggcaggattt ttaagtagtg gtaggaaaaa atgataaaaa gaaatgaatt
    10021 aaagttagag tatcagcaac atcagtttta cgaatacttt aactcaattt ttgattacga
    10081 catattagat acttctatta gtgaaaatat ttatttgtta agggaaaaga cacataagtt
    10141 attttatagt gagtttgaaa atcagttatt tgaaactata atgtttcttt caatgaaaac
    10201 actagttcta gatataaatc atttttccaa ggaaattgaa aacaagtcaa aggcatatga
    10261 acaatatata cagcagataa gggaagaaaa tgggataagt aatttttttg acagatatcc
    10321 atatttgcta aaacaaatca atagagaagt tggattggta gtggaatcat actctttgct
    10381 atttgatagg tttttaaaag atttgtctga aataaggtca tgctttaata ttactgagtc
    10441 cttaagtaat gttgaatttt cacttggaga cagtcattcc caaaaacaaa cagtcgttaa
    10501 gattgaattt aaagggaaat ccgtttacta caagcctaaa agctatgatt catacaacat
    10561 cttgttggaa cttattagtc tattgaaatc taataatata ccttcgttca gtcttcctga
    10621 aagcttaatt aaagcggatt attgttggca acttggtgta gcttatacaa gttccaataa
    10681 agatgaagta gcgaaaattt actttaagta tggtgtttta gcagcatttt ctgaaatatt
    10741 ttctattacg gacttacata tggaaaatgt gattgtttca ggcggagatt tatatttaat
    10801 tgacgttgaa accttttttc aaagaaagtt gaatgtacaa aatcagaatt ttgaagggat
    10861 tactgtagac acctatcaga gaatttataa gacatcactt tcaaatggtt tatttcctgt
    10921 acaatttgag aaaaacagcg ctcctaacgt ttctgggata agtggaaaag gtgggaaaag
    10981 aaaaaaggga aagtatgaac tgataaataa aaatcgtgga gatatgaagt tagtgaaaac
    11041 tgactatttt caggaagatg gttataatat tccgacatta aatgggaaag tagtggaacc
    11101 tctcgactat gctaatgagg taattgcagg ttttagagaa tgctatacat ttcttatgtc
    11161 gcaacgtgca aaggttaaaa aaattttaga agatttccca aaattgaaaa ctagagccat
    11221 attcagaaat acttccgact atggaaaatt tttacaagcc tctacgaatc caaaatatct
    11281 tttctcagaa aaaaagaggg agaatttatt ttcgatacta catgagtcaa aacatattga
    11341 acaatttatt gttgttagtg aaattaaaga tttgatgaat ggtgatattc cttacttttc
    11401 aatggatacc agtggaaatg tatataattc tttaggaaca gtaattggaa atctaggaga
    11461 gacaacctca ttatttgata atatagctac cctgaatgat gaaagaatga agttcacttg
    11521 cgaattgctt ggaatagtct tgaaaaaacc gattaagcat tgggagaggg aaaagggcaa
    11581 atcttatcag tttttatcaa tctcctcaga acacaatttt agtgaggaaa tcttagacag
    11641 cattagacga atatttattg atgcagataa gaatagcttt tcttcagagg aggagataac
    11701 atggctcaat attgatatta cagagactga gcaatgggta atatctcctc agaacattac
    11761 cttgtataat ggattgattg ggaatgcctt aggttattta tatgcttatc aaattcttgg
    11821 tgaagagcaa tatctagtat cattaaataa gatattgaaa acattggaaa ccacaaagaa
    11881 tcttatagaa actagtgata tgtcagtttt tttgggaaaa ggaggtttga tttatctata
    11941 ctttagtttg tggaaaagac ttaaattacc tcaataccaa aaattatatt tagacataat
    12001 caaagaattt tccagccagt cactagagga gcaaaatata gattatattt ctggagtgtc
    12061 tggtttatta gttgttctgt gcaacatata taatgtagag caaaataaaa cagtatatca
    12121 tttaattaat aggatatctg aatttattat tgataatgtg aaaaaagaag atgataaggt
    12181 ttattgggta tcggattttt cagattcaga aattctaaat ggactatctc acggacaatc
    12241 tgggattgca tatgcattac ttttatcatg gaaaatcaat aaaaattata attattttaa
    12301 aatagcgaag tcagctattg attttgaaaa tacccgtatt tctgatggaa attggattga
    12361 ttttagaaat aaaggaaaac gttcagagtt aggaatgcca gaacctattt attggtgtca
    12421 tggtgcaaca ggtatcggat taacgagata tagagaatca aaatggttaa acgataaaga
    12481 gttgaaaaat aattatgaaa tggctaaaca aacggtatta aataatggtt atttgaattc
    12541 ggattgcctt tgtcacggga aaatgggcaa catggaatta tttatgaatt tagatgactc
    12601 cttgaaaaat gaagtagata tagaaggtat catacttaat attgttcgta attctcaaaa
    12661 atttggttgg gaatctggct tgccacaaca cacaagagtg tttaatatga tggttggtga
    12721 aatagggata gcataccagt tacttagata tatatccaat tatgaagtac catcattatt
    12781 gttattagat gttccaaaag ggagtattga aaatgaaaaa gattacaccg attgaacaaa
    12841 caactcctac tgaatgtgga ttatgttgtt tatatatgat gttagattat tttgatattc
    12901 cagaaacata ttttaaattg aaacaacaag tcaatttagg gagaaatgga ctgagtataa
    12961 agaatatctc agatattgct tctatctacg gagttacttg taagacttat cgtttttcca
    13021 aatatcccga aaacttacct gtcatggtat ttgtttcaga ttcgcatttt gtaattttag
    13081 aggatattcg tgatgatgcc tttactattg ttgaccctgc tgttgggaaa tatgtcttag
    13141 caaagaatga attttttgaa ttatctccta aattttatac cgaatttttt tatgataagg
    13201 cgactaattc ttcaaaaaaa atagccaaac gaggattagt tggcagaaac gtaaaggaaa
    13261 tgatatttgt aaataggaag gatacttttt taaccattct atatactctg atttttcaga
    13321 ttatcacagt gtcaattcca ttttttataa ggggaattat tgatggaaat tgggttttcc
    13381 ttaaaaagtt tggctattta gaaagtgcag tcctactttc tataataatt tttttcaggg
    13441 aggattttat ttaatttttt attcctgatg gtttttacta ttttacacct gtatccgtta
    13501 ctagttatag tgctatatta taggtccttt aggcaacaaa tatcagttgt tagacgttca
    13561 ttgatactat tttctttact tttgctggta atacttggta gtgaacttta tggagaaatg
    13621 ctagatgtta atcaagcctt taataatttg ggatggtatc tgtttcccct tataatgagt
    13681 gtaatatact attttaagac catacatgat aaattgagtt ttgttaccca aagatggtta
    13741 ggtgattaca aagctcgtat agaactatta tttctacttc ttatcctttg ttgggttgta
    13801 ctcataaagg tactagttaa agaattttta ttatttttta taattgttga cgcaagcacg
    13861 ttattttgtc tagtggtaat ttcttgcatc ttttattatt tagaaaactc caaacaaaat
    13921 tttgactatg aaaatagaag actgaactat tttatgaaat cagaggaaaa catgagagtg
    13981 gagttctcaa attatttgca tgatgatgtt ttacaaaata tcatagcgat aaaaaactcg
    14041 ctttctctag aaaatagtaa tataacacat ggttttattg ttaatgagtt gaatgattta
    14101 gtttctggta tcagagaaga aattgatact taccacccaa tagttcccgc taatcaaaca
    14161 atgaaagaaa acatacagtc tctttttgat gatattgtta aaagtagaaa aagtaatacc
    14221 ttattgtatt ttaactgttc agataatatg gtagtgccat ccccatatgg agatattgtt
    14281 tataggttta taaaagagct aataaacaat gctataaaat atggagatgg aaaagacatt
    14341 cgtttatctt taacgattca atctgatatt attatcattg aggagagcaa tcaagtagtg
    14401 gaaaaagtac actctataag ttatggcaga ggattgaaat catttcaaga aacactagca
    14461 gcttttgatg gagatctaga actacaaatg gatactaaac aatttactat cagaatatta
    14521 cttcccatag attggaaatt gtgttatgaa gattttatta attgatgacc acagactatt
    14581 tgcaaagagt atccaactgt tattccaaca gtatgatgaa gtagatgtca tagatacgat
    14641 tacttctcat tttaacgatg tgacgattga tttgtctaag tacgatatta tattgcttga
    14701 tattaattta acaaatattt ctaaagaaaa tggattggag atagcaaaag aactcataca
    14761 gtctactcct catttgaaag ttgttatgtt gacaggatat gttaaatcaa tctatagaga
    14821 gagggcaaaa aaagtaggag catacggttt tgtagataaa aatatagacc ctaaacaact
    14881 catttctatc ttaaaaaaag tggattctgg aaaaaagtat tttgaacaaa tcgaatctca
    14941 ggattatgtt gaatctttaa ctgaccagga aatagctatc ttaaatttga gtaagaaagg
    15001 attctctata aaagaaatag aggaaacgtt acaaattagt aggagaacag tatttaatca
    15061 tttgacccac atctactcaa agcttttggt aaataataag caagaggcta tctacaaagc
    15121 cgaacaatta gggtatttta tggatttctg agttgcagat aatcaaacga cataagtttt
    15181 acttgtgtcg ttgctaggga tttcctgtta aatactcaga tttaaactca ttgtttttga
    15241 gttctttttg attgaaattg attgagataa cgcttttata aaaagtaggg aaatgcctga
    15301 tatgaaaagc tttttaaatt tagtcaaaca aaagttgttt aaaccaggtc taaaaaaact
    15361 cgtaaagctt cacaactccc agaacgttaa tatatgctta tatatcaacg attggaacta
    15421 ctttatggtt cgcaccatgg tttttgtgga aggatcaaaa gttgtcctga aaatttctct
    15481 taaccgtgtt taagctttct aaacgtttga gaaatcattg taacttcaaa taactatttt
    15541 aaataaaaca aagaaacgga caaagttaga tgagatgatt ctattttgat ttataggtga
    15601 agaaggagaa tcttgtatga taagtactca ataaaggttc actactcaat tttaaataaa
    15661 acgccacagt agtaatcatc tactgtggtg tttttttgtc ttttagtttc taaaagtatc
    15721 caattcgtct tgtgcttctt tggttgttcc gactagttgt ttcatgagtt gatctagttt
    15781 ggcatttgtt ttggcaattt cttgatcaat gtcactgagc tgtttagcta attctggcag
    15841 tggtttaact gggacttcct caaaggtatc aacatagcgt gggatattta agttatagtc
    15901 attttcaatg atttcatcaa atgaggctaa atatgaaaac ttatcagaat tatcacgact
    15961 cttataagca tcaaggatct ttttgatatg gctatctgtc attgtgtttt gatttttgcc
    16021 cttatcaaac tcttttgagg catcgataaa gaagacatct ttgttggttc tgttcttctt
    16081 taatatgata atagtcgtag ggatgcttgt attataaaag atatttgatg ggagtccgat
    16141 aatggtatcg atagcccctt gttctagtaa tttttggcgg attttgcctt ctgcagcacc
    16201 acggaaaaga actccatgtg gtaagacaat cgccatggtt cctgtatttt ttaaatgata
    16261 gaaaccatga agtaaaaagg caaagtcagc ttttgatttt ggtgctaata caccataact
    16321 tgaaaaccgt ggatctgtta agaaaccagc agtcgctgac catttcaaag aataaggtgg
    16381 gttcatcaac accccatcaa agttggttgg ctcatctgtt ggccagtctg catccaaggt
    16441 atcagcgtta cttaagtgtt ggttttcgat ggcaacgcca tgaagcatca tgttcatacg
    16501 agccaagtta taagtagaag tattgatttc ttgaccatag taagaaacgg tatcggattg
    16561 gttactatat ttcttagcat ttaaaaggag tgatccagat cccatagcag ggtcatagag
    16621 ggtcattcct ttttgatctt cacgacctaa aaagacaatc tgagtcatca agtgagagac
    16681 agcttgtggg gtatagaact cacctgcttt ttttcctgac tcactggcaa attcaccaat
    16741 caagtactca taagcatcgc ctaaagtatc cccatctact gcctcaaagt caatttcatt
    16801 taatgttttc atgacattag aaatggtttg attttgtttt tgaggagtag agcctaattt
    16861 tttagagtag aggtcaatat cttcaaataa gttttcaaag tcttcaccac tttgttcaat
    16921 atcgcgaaaa ccttgagcta atgattctaa ttggaaagta ttgtgataaa catcttggat
    16981 gagtttttca aaggtcagtg ttggttcgat aaagtaacct aaatcaccag taacaacaga
    17041 aatgaggtca tcttttaggc cttcatcttg ataagcatct tcaaagattt tttgagcctc
    17101 tgtaaaggta ttgaagtgtt tttctagatt atcacaaaca gccaagagta atttatcaga
    17161 taagtgtttg taaaaaataa gtccaagaag atagttttta tagtcattgg catccatttg
    17221 gccacgtaat tggtcggccg aatgccatag tgcttgacgg agtgaagttg ttttctctgc
    17281 catgtgagtc ctttcttata cgaataaacg attgagtaat gtttgtttga gtgctttaag
    17341 ttctgttaat ttatcttcga tttgactcat ttgttggtct agggtttgga agaagtcacc
    17401 gatggcttct tgttcgggga gggagggtag ataaagctct aatcctttca caatggaacc
    17461 agataaattt ccttgaccac cctgtaaata tttctcaata attgaagatt tttgtttata
    17521 taaccaattt tttataaaaa gagaagaata ttttttctca ggaataatgg ctaaaattgc
    17581 ttgattaata gctccactta ttcttgaaag tccaacttct ccactagttg caccgtagag
    17641 agcgtataat aatgtatttt tttccactat ttttgctgat gaatttgata gacctttgtt
    17701 tgtgataaat aactctgttt gatcactatt aatctcagaa gatctaatga aaggaatatt
    17761 accgttatag tattcagaaa tacctacgct aggagtacca cctgaaaaca tccgagatat
    17821 ctctcccaat ttcttctctt cccactcacc atcaaaacct tgtaaacgga tttcagggac
    17881 tttttgtcct tgagctggga acatctttct gaggaaggtt tgcttttgtt cttttagagt
    17941 tgctagcttt tgatcctgca actgaatcaa ttgatcaacc gtttggaaaa gttcgccaat
    18001 agcttcttgt tcggggaggg agggaatttg aattttagca tatttgatat tactagagct
    18061 aatgctatca aaagttgaac ctgtactaat tcttttccaa taaccaattt ctttcaagta
    18121 ttttaatatt tgaaagataa attcattacc ttttatagca gcaactccac gcccaataat
    18181 aacatgataa tttgtctttc caacatcacc aactggagcc ctaacactaa gaataatatc
    18241 acctttgtca gcttgttttg taatttgtgt tgtccagaca cgcggaaaaa catatccatt
    18301 ttttatatcg gcatttcctt gtactagaat ataatcagaa gggtttgtag tataattttg
    18361 acttgatgga gattggccca ttgtaatttg aacaatatcc cctagttctt tttcttccca
    18421 ctccccttca aaaccgtcaa agcgatattg aggctgttta gattttgtca tctctttcct
    18481 ttcctagtgc ccttttaagg gttggatttg atctctaatg aattgaacta actcccgttc
    18541 aaattggctc ttgtatttga gtttattcat ggcagaatca ccttgttttt ctttataggc
    18601 ttggtagtct agggattctt ttaaggttga catgcccact tgtttggtag agttagcact
    18661 atgataatta gtcgccacaa aggctaattt gtcaggatct gccttccact ggtccgcaaa
    18721 gtatttgatg gccctttgga tcttatcacc aatgaggtta tccaactcat aagcaatgct
    18781 tttcccttca taggctttgg gttctttttg gatatcttgc cataactcag ctagtgagtc
    18841 agccatagca gggtttgatt ttgccaaatc ttggatgtat tgatccatgg gattgtcatt
    18901 gagcctttct tgaagagctt cttgttcttg atcgacaaag gcttgaatta aggtcaagat
    18961 atagtgatag ttgatatcat ccatctgaac actttctagc tcatagtcga tattgatctc
    19021 tgggatggct tcgtcatctt ctcttcgttt tcgtatttct gcaatgacat tttggtaagt
    19081 gcctttataa gtatcaatca cttcatctga taacccaacc tcactcaaca gtgtttcatt
    19141 aaagtcacta tagacctgta cagatgcaaa gagtttatca aacgcttgaa aggctttggc
    19201 gtattgtttg agaaaagctg tctgtgcgct ctcaatagtt gggaaagcgt ctggatcagg
    19261 aactatattt tttaatactg ttacgttttc aaggaatctt gctttttctt cttcccaaga
    19321 aggggccaaa acgtcgtttt cacccccatt agagtagagg ctaagcgctt tgtcgacagc
    19381 ttctttaaaa cgaagtggtg tttggaaagt cacaacctga ccgtaatgtt ttctactttc
    19441 aaagatacgg ttggttcgtg agaaagcttg aataatgtgt tgaggtttca taggctggcg
    19501 atcgatgaag atggttgata aacaaggcgc atcaaagcct gttaagagac ggtcaaccac
    19561 aatcacgagg tctaattgtt catgacggtc tttgaattta tcttttttac gggctaagcg
    19621 atcatttaaa tctctgttat agccttgtaa gttatcgatg gtaaagttag tgccaaagag
    19681 gtgattatag tcttctagat ttttggtcat tttatcttgt cggctgatag acgcattgtc
    19741 attttcagtg atagaataag taatagctac ctttggaaag tctggtagtt tttctttgac
    19801 cttcttagaa atgactaaat ccgtttcacc agccttaact ttcttcatca gatcataata
    19861 ggcttgggca cgagcaatac tcttaacggt tagtaaacct tcgaatgtct gaccaattcc
    19921 attattaaaa ccaagtttct tgcttgattg attaatgata ctatctaaga cagctaacat
    19981 atgttcttca tgatcataag cttcttccgg aatactgtct tcaggcatat caggaatggt
    20041 tgtcttatac tcaacttgaa agcctagaac cgctttatca tgaatggctt ctttaacggt
    20101 gtattgatgg agacatttgc cgtattgctg ttccgttgtt tgggctaaat cacctaattg
    20161 agcacgctta ttttccacaa agataggagt gccggtaaag ccataccagc gactgttacg
    20221 aaaagtattc gtgagataac gttgacgttc cggtgtgaca gcacggtggc attcgtccac
    20281 aacaaagaca acatttaagt gtgcaagacg ctcttttagt ttcttgaatt ttggagtgtc
    20341 ataactttcc atctgactga tcatggcatt gagtttttga atggtggtga ccacaacacg
    20401 acgatcactg gattctaaat ttttgatgag ttgtctcgta tcttctgtct catcgacatc
    20461 aaagatatca ttttgcgcat aggattgaaa agcagaagcg gtctgattat ctaaatcctt
    20521 tcggtcaatg acaaagatgg atttttcaac ggccggtatt tgaaggatat tgcgagccac
    20581 tttataggaa gttaaggttt ttccagaacc tgttgtgtgc cagatatagc cagacttgcg
    20641 gtgacgactc gcttcagcga cggcttcgat tgcatgaatc tgataaggac gaaggagaat
    20701 tagtgctttt ttatcatcat caatgacaga gtaagtcatg accatttggt gagcacgagg
    20761 gatagatagg acttctttgg caaaggcaaa gagatctttt tgtggtttgt tgttttgatc
    20821 tacccattgg gtcaagaagt tagggtttaa tttattttct ttagctgcag cgatatacct
    20881 tgtatctgtt ttatttgaga ccacaaacat ttgtaaggtt gaaaagatac ctctaaactg
    20941 gccttcttta tcatactttt tgacttggtt aaaagcttca atgcattgat gattctgaga
    21001 ttttaattca atttggatca taggtaagcc attgatgaga agtgtcacat cacctcgtct
    21061 atcacgagaa ccagagaaag caacttgatt ggcaatctca taaacagaag ttccaccagc
    21121 cacattgtct gctttaacga cttctaaacg aatcgttcct agttttgcat cttcgcgttg
    21181 cacttgtact ttagcaatgc cgttttcacc agctaaccat ttagccgctt catagtaatt
    21241 gacaaagtta agttgattct taatctgctc tttttcacta gctgttaaag gctcctcgtt
    21301 cagatattgc gtgttatttt gcgctaagat cttaaagaaa ttatcccata aagcatcttc
    21361 agtttttaat tctttacgat atgtccattg actttcacct gtttctaaga gatggatcaa
    21421 ctctttttca agttcaagtt ccgttttagt ttgatttccc atttttaatc cccattcgac
    21481 atgatatagt aatattatat cattggcgga tcctttttag aatggcaaag ctattgaaac
    21541 cttccaaaca gtcttttttt gattagttga atgcttaaga tcctagcaac taaacaaagc
    21601 tatgactatg taaatgcaat cgagaaagtt cttgtatttt tgagtttgct tgacaataat
    21661 ttaaggtgaa gaaagtaata agacaacatt agtaaaaagg tcgagttctc aaaatagata
    21721 aaaaacttaa gacagatcta gcttgactat taatagggtt ttaaaggacg ataatctgct
    21781 acaatataca gaaaaggaat ttattgaaga tatgaaaatt ttggtagcca tagattcttt
    21841 taagggatcg gtaacgtctc cagaacttaa cactagtgta gctcaagccc ttctttctgt
    21901 cgataagcag ttagttattg aaacaagagc tatcgctgat ggaggagaag gaagtttagc
    21961 agccctctca caaaccgtgg cggggaggtg gcatcaagta aaaaccattg atctattaag
    22021 acgcccgatt aaagtcgctt attatcgtca cgcaaagcaa gcttttattg aatctgcgag
    22081 tattattggt attgataaga tcacccccaa ttcagtaacc tatgcacaag ccacttccta
    22141 tggtttgggt ttggcagtta aagatgccat tcaaaaagga gctactcaaa tcgaaatcat
    22201 gctaggagga acaggcactt ctgatggtgg caaagggttt ttggaaagtt taaactatga
    22261 tttcatgaca ggaagatctt atcttgatac tttagcatca cctgttacgc tattagggct
    22321 gactgatgtg accaatccat atcatggccc tcaagaattt gctgcggtct ttggccctca
    22381 aaaaggtggg agtcttagtc aaattgaaga aactgatcaa attgcaagta actttgctaa
    22441 aaaagttttt tgccaaacaa ccattgattt acagacaata ccaggaagtg gagcagctgg
    22501 aggattagga ggtgccattg tcctattagg aggcacctta actagtggtt ttagcaggat
    22561 tgcagagcta ctaaatctgg ataattccct tcagtcttgt gatttagtta ttactggaga
    22621 aggatgcctg gatacacaat cacaatctgg caaggtacct gttgcgattg caagaatggc
    22681 taaaaaatat caagttccaa cgattgctct atgtggttct gtaaagattg agacaggact
    22741 agcagcagaa gactttttgg ctgttttttc aatacaacag cagccaattt ccttagaagc
    22801 agcgatagat aaaacaacaa cactttctaa tatca
//
