GCF_900984225.1 - 5 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CAAHMR010000001.1 (Streptococcus pyogenes)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	T3PKS	330,740	371,915
Region 1.2	azole-containing-RiPP	474,998	498,764	High	streptolysin S	ribosomal:RiPP:LAP
Region 1.3	RiPP-like	643,011	653,227

NZ_CAAHMR010000003.1 (Streptococcus pyogenes)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 3.1	lanthipeptide-class-ii	10,153	32,987	High	salivaricin A	ribosomal:RiPP:Lanthipeptide

NZ_CAAHMR010000004.1 (Streptococcus pyogenes)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 4.1	terpene-precursor	84,534	105,406

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	T3PKS	330,740	371,915
Region 1.2	azole-containing-RiPP	474,998	498,764	High	streptolysin S	ribosomal:RiPP:LAP
Region 1.3	RiPP-like	643,011	653,227
Region 3.1	lanthipeptide-class-ii	10,153	32,987	High	salivaricin A	ribosomal:RiPP:Lanthipeptide
Region 4.1	terpene-precursor	84,534	105,406

No secondary metabolite regions were found in these records:: NZ_CAAHMR010000002.1 (Streptococcus pyogenes); NZ_CAAHMR010000005.1 (Streptococcus pyogenes); NZ_CAAHMR010000006.1 (Streptococcus pyogenes); NZ_CAAHMR010000007.1 (Streptococcus pyogenes); NZ_CAAHMR010000008.1 (Streptococcus pyogenes); NZ_CAAHMR010000009.1 (Streptococcus pyogenes)

Compact view

NZ_CAAHMR010000001.1 - Region 1 - T3PKS

Download region GenBank file

Download region SVG

Location: 330,740 - 371,915 nt. (total: 41,176 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: reductase

E9727_RS01815: hydroxymethylglutaryl-CoA reductase

smcogs: SMCOG1187: hydroxymethylglutaryl-CoA reductase

Hydrolases: amidase deformylase esterase

E9727_RS01720: amidase

smcogs: SMCOG1105: amidase

E9727_RS01855: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

smcogs: SMCOG1283: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

E9727_RS01860: peptide deformylase

smcogs: SMCOG1275: peptide deformylase

Ligases: synthase

E9727_RS01810: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002561.3	0.44	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000934.4	0.41	other (phenazine)	5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G	Kitasatospora sp. HKI 714
BGC0001080.5	0.41	other (phenazine)	endophenazine A, endophenazine B	Streptomyces anulatus
BGC0000286.3	0.40	PKS	viguiepinol	Streptomyces sp. KO-3988
BGC0002284.3	0.39	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0002362.3	0.38	PKS	loseolamycin A1, loseolamycin A2	Micromonospora endolithica
BGC0001863.4	0.38	ribosomal, terpene	bacillicn CER074	Bacillus mycoides
BGC0001521.3	0.38	NRPS	auriculamide	Herpetosiphon aurantiacus DSM 785
BGC0000679.5	0.38	terpene	diazepinomicin	Micromonospora sp. M42
BGC0000515.4	0.37	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002561.3	0.44	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000934.4	0.41	other (phenazine)	5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G	Kitasatospora sp. HKI 714
BGC0001080.5	0.41	other (phenazine)	endophenazine A, endophenazine B	Streptomyces anulatus
BGC0000286.3	0.40	PKS	viguiepinol	Streptomyces sp. KO-3988
BGC0002284.3	0.39	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0002362.3	0.38	PKS	loseolamycin A1, loseolamycin A2	Micromonospora endolithica
BGC0001863.4	0.38	ribosomal, terpene	bacillicn CER074	Bacillus mycoides
BGC0001521.3	0.38	NRPS	auriculamide	Herpetosiphon aurantiacus DSM 785
BGC0000679.5	0.38	terpene	diazepinomicin	Micromonospora sp. M42
BGC0000515.4	0.37	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.77 out of 27.78

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.20 out of 24.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.60 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.30 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.93 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.33 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.36 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.62 out of 26.06

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.60 out of 32.93

Confidence: medium

Additional weak hits (2):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.77 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.28 out of 28.14

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 2	Repressor of DNA damage response
LexA variant 3	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes

NZ_CAAHMR010000001.1 - Region 2 - azole-containing-RiPP

Download region GenBank file

Download region SVG

Location: 474,998 - 498,764 nt. (total: 23,767 nt) Show pHMM detection rules used

azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Azole RiPPs

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase

E9727_RS02495: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000566.5	0.98	ribosomal	streptolysin S	Streptococcus pyogenes M1 GAS
BGC0000564.5	0.69	ribosomal	clostridiolysin S	Clostridium botulinum A str. ATCC 3502
BGC0001170.5	0.63	ribosomal	clostridiolysin S	Clostridium sporogenes ATCC 15579
BGC0001171.5	0.50	ribosomal	listeriolysin S	Listeria monocytogenes serotype 4b str. F2365
BGC0000569.5	0.49	ribosomal	plantazolicin	Bacillus velezensis FZB42
BGC0001173.5	0.48	ribosomal	plantazolicin	Bacillus pumilus ATCC 7061
BGC0000605.5	0.42	ribosomal	GE37468	Streptomyces sp. ATCC 55365
BGC0002700.2	0.41	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0001887.3	0.39	ribosomal	huazacin	Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0002111.3	0.39	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000566.5	0.98	ribosomal	streptolysin S	Streptococcus pyogenes M1 GAS
BGC0000564.5	0.69	ribosomal	clostridiolysin S	Clostridium botulinum A str. ATCC 3502
BGC0001170.5	0.63	ribosomal	clostridiolysin S	Clostridium sporogenes ATCC 15579
BGC0001171.5	0.50	ribosomal	listeriolysin S	Listeria monocytogenes serotype 4b str. F2365
BGC0000569.5	0.49	ribosomal	plantazolicin	Bacillus velezensis FZB42
BGC0001173.5	0.48	ribosomal	plantazolicin	Bacillus pumilus ATCC 7061
BGC0000605.5	0.42	ribosomal	GE37468	Streptomyces sp. ATCC 55365
BGC0002700.2	0.41	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0001887.3	0.39	ribosomal	huazacin	Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0002111.3	0.39	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.98 out of 20.97

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.45 out of 26.06

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.03 out of 20.97

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.90 out of 26.06

Confidence: medium

Additional weak hits (4):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.72 out of 30.22

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.53 out of 33.73

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.68 out of 32.74

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.38 out of 27.18

Confidence: weak

(Thi)azol(in)e containing peptide predictions

No core peptides found.

RREFinder

TFBS Finder

Azole RiPPs

RRE predictions

: RRE type: Cytolysin_C_RRE; Location: 0 - 90; Score: 134.1

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
MogR	Repressor of flagellar motility genes

Core peptide predictions

No core peptides found.

NZ_CAAHMR010000001.1 - Region 3 - RiPP-like

Download region GenBank file

Download region SVG

Location: 643,011 - 653,227 nt. (total: 10,217 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	RiPP-like	Similarity score	Type	Compound(s)	Organism
BGC0000526.5		0.22	ribosomal	macedocin	Streptococcus macedonicus

Reference	Aggregated	Similarity score	Type	Compound(s)	Organism
BGC0000526.5		0.22	ribosomal	macedocin	Streptococcus macedonicus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (3):

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.42 out of 29.72

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.57 out of 26.85

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 18.45 out of 30.12

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description

NZ_CAAHMR010000003.1 - Region 1 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 10,153 - 32,987 nt. (total: 22,835 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: kinase

E9727_RS05535: PfkB domain protein

smcogs: SMCOG1276: PfkB domain protein

Lyases: cyclase

E9727_RS05505: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000548.4	0.77	ribosomal	salivaricin A	Streptococcus salivarius
BGC0001787.3	0.56	ribosomal	suicin 3908	Streptococcus suis
BGC0002698.2	0.51	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002005.2	0.50	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0001210.5	0.50	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000500.5	0.47	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000498.5	0.47	ribosomal	bovicin HJ50	Streptococcus equinus
BGC0000561.5	0.47	ribosomal	thermophilin 1277	Streptococcus thermophilus
BGC0001391.3	0.45	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000557.5	0.44	ribosomal	streptococcin A-FF22	Streptococcus pyogenes

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000548.4	0.77	ribosomal	salivaricin A	Streptococcus salivarius
BGC0001787.3	0.56	ribosomal	suicin 3908	Streptococcus suis
BGC0002698.2	0.51	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002005.2	0.50	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0001210.5	0.50	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000500.5	0.47	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000498.5	0.47	ribosomal	bovicin HJ50	Streptococcus equinus
BGC0000561.5	0.47	ribosomal	thermophilin 1277	Streptococcus thermophilus
BGC0001391.3	0.45	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000557.5	0.44	ribosomal	streptococcin A-FF22	Streptococcus pyogenes

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for E9727_RS05505

E9727_RS05510

Leader:

MSFMKNSKDILTNAIEEVSEKELMEVAGG

Core:

KKGSGWFATITDDCPNSVFVCC

Core with dehydrations:

KKGDhaGWFADhbIDhbDDCysPNDhaVFVCysCys

antiSMASH-DB 4.0 matches for E9727_RS05510

100.0%

NC_004070.1and 26 others:

NC_008024.1 Lanthipeptides: MGAS10750_RS08460_lanthipeptideNZ_CAAHHZ010000002.1 Lanthipeptides: E9518_RS02835_lanthipeptideNZ_CAAHIH010000002.1 Lanthipeptides: E9602_RS03585_lanthipeptideNZ_CAAHIO010000002.1 Lanthipeptides: E9584_RS04360_lanthipeptideNZ_CAAHJE010000002.1 Lanthipeptides: E9605_RS03435_lanthipeptideNZ_CAAHJS010000002.1 Lanthipeptides: E9628_RS02300_lanthipeptideNZ_CAAHKC010000012.1 Lanthipeptides: E9636_RS08085_lanthipeptideNZ_CAAHMR010000003.1 Lanthipeptides: E9727_RS05510_lanthipeptideNZ_CAAHQE010000003.1 Lanthipeptides: E9931_RS04945_lanthipeptideNZ_CAAHQG010000004.1 Lanthipeptides: E9903_RS05690_lanthipeptideNZ_CAAIFD010000008.1 Lanthipeptides: FAG63_RS07845_lanthipeptideNZ_CAAJDK010000010.1 Lanthipeptides: FAO79_RS08000_lanthipeptideNZ_CAAJFI010000003.1 Lanthipeptides: FAP60_RS03740_lanthipeptideNZ_CP008926.1 Lanthipeptides: DP15_RS03855_lanthipeptideNZ_CP035434.1 Lanthipeptides: ETT65_RS08240_lanthipeptideNZ_CP035435.1 Lanthipeptides: ETT64_RS07905_lanthipeptideNZ_CP035447.1 Lanthipeptides: ETT52_RS07920_lanthipeptideNZ_CP035449.1 Lanthipeptides: ETT50_RS08255_lanthipeptideNZ_CP035453.1 Lanthipeptides: ETT46_RS08220_lanthipeptideNZ_CP060646.1 Lanthipeptides: H7789_RS07920_lanthipeptideNZ_CP065054.1 Lanthipeptides: I2432_RS09105_lanthipeptideNZ_LRGW01000003.1 Lanthipeptides: AWU01_RS03260_lanthipeptideNZ_LS483298.1 Lanthipeptides: DQM39_RS08650_lanthipeptideNZ_LS483407.1 Lanthipeptides: DQM86_RS08100_lanthipeptideNZ_LS483425.1 Lanthipeptides: DQN36_RS07865_lanthipeptideNZ_LS483430.1 Lanthipeptides: DQN28_RS07600_lanthipeptide

Lanthipeptides: SPYM3_RS08605_lanthipeptide

KKGSGWFATITDDCPNSVFVCC

95.5%

NZ_CAAIJM010000014.1:

Lanthipeptides: FAI23_RS09465_lanthipeptide

KKGSGWFATITDDCPNSVFVCC

KK SGWFATITDDCPNSVFVCC

KKVSGWFATITDDCPNSVFVCC

90.9%

NZ_CAJHJN010000010.1and 4 others:

NZ_CP066093.1 Lanthipeptides: I6I02_RS06995_lanthipeptideNZ_JACLQK010000029.1 Lanthipeptides: H7U04_RS10750_lanthipeptideNZ_JADPEB010000003.1 Lanthipeptides: I4U26_RS02855_lanthipeptideNZ_KV832031.1 Lanthipeptides: HMPREF2637_RS05170_lanthipeptide

Lanthipeptides: JMZ68_RS08975_lanthipeptide

KKGSGWFATITDDCPNSVFVCC

K+G+GWFATITDDCPNSVFVCC

KRGTGWFATITDDCPNSVFVCC

with 66 more sequence matches

Only the first 10 are displayed here.

86.4%

NZ_JAQDVH010000019.1and 3 others:

NZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09335_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06620_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06620_lanthipeptide

Lanthipeptides: PGU04_RS09335_lanthipeptide

KKGSGWFATITDDCPNSVFVCC

KKG GW ATITDDCPNS+FVCC

KKGPGWIATITDDCPNSIFVCC

86.4%

NZ_PKIA01000004.1:

Lanthipeptides: CYK22_RS03780_lanthipeptide

KKGSGWFATITDDCPNSVFVCC

K+G GW ATITDDCPNSVFVCC

KRGPGWIATITDDCPNSVFVCC

81.8%

NZ_CP018188.1and 1 other:

NZ_VDNV01000006.1 Lanthipeptides: FSV44_RS08680_lanthipeptide

Lanthipeptides: BSR19_RS10820_lanthipeptide

KKGSGWFATITDDCPNSVFVCC

K+G GW ATITDDCPNS+FVCC

KRGPGWIATITDDCPNSIFVCC

77.3%

NZ_CP048273.1and 3 others:

NZ_CP048273.1 Lanthipeptides: M654_RS18555_lanthipeptideNZ_LT745776.1 Lanthipeptides: B2C81_RS11280_lanthipeptideNZ_LT745776.1 Lanthipeptides: B2C81_RS11275_lanthipeptide

Lanthipeptides: M654_RS18560_lanthipeptide

KGSGWFATITDDCPNSVFVCC

G GW TITDDCPNSVFVCC

AGCGWACTITDDCPNSVFVCC

77.3%

NZ_CP048890.1and 3 others:

NZ_CP071478.1 Lanthipeptides: J0P05_RS32905_lanthipeptideNZ_LUCO01000008.1 Lanthipeptides: BMBG_RS24280_lanthipeptideNZ_NVLN01000014.1 Lanthipeptides: CON11_RS24965_lanthipeptide

Lanthipeptides: BMG_RS30865_lanthipeptide

KGSGWFATITDDCPNSVFVCC

G GW TITDDCPNSVFVCC

AGCGWSCTITDDCPNSVFVCC

77.3%

NZ_NIHT01000008.1and 1 other:

NZ_NIHT01000008.1 Lanthipeptides: CDL23_RS06740_lanthipeptide

Lanthipeptides: CDL23_RS06745_lanthipeptide

KGSGWFATITDDCPNSVFVCC

GSGW TITDDCPNS+FVCC

NGSGWLPTITDDCPNSIFVCC

72.7%

NZ_CP036073.1and 11 others:

NZ_CP036073.1 Lanthipeptides: EXW45_RS04930_lanthipeptideNZ_CP036073.1 Lanthipeptides: EXW45_RS04925_lanthipeptideNZ_CP036073.1 Lanthipeptides: EXW45_RS04920_lanthipeptideNZ_CP036073.1 Lanthipeptides: EXW45_RS04915_lanthipeptideNZ_CP036073.1 Lanthipeptides: EXW45_RS04910_lanthipeptideNZ_NUEG01000031.1 Lanthipeptides: CN905_RS18915_lanthipeptideNZ_NUEG01000031.1 Lanthipeptides: CN905_RS18910_lanthipeptideNZ_PVRT01000001.1 Lanthipeptides: C6359_RS05275_lanthipeptideNZ_PVRT01000001.1 Lanthipeptides: C6359_RS05270_lanthipeptideNZ_PVRT01000001.1 Lanthipeptides: C6359_RS05265_lanthipeptideNZ_PVRT01000001.1 Lanthipeptides: C6359_RS05260_lanthipeptide

Lanthipeptides: EXW45_RS04935_lanthipeptide

KGSGWFATITDDCPNSVFVCC

G GW T+TDDCPNSVFVCC

AGCGWLCTVTDDCPNSVFVCC

72.7%

NZ_JANHJQ010000013.1:

Lanthipeptides: NON16_RS14160_lanthipeptide

KGSGWFATITDDCPNSVFVCC

G GW T+TDDCPNSVFVCC

DGCGWSCTVTDDCPNSVFVCC

68.2%

NZ_MJEH01000022.1and 1 other:

NZ_MJEH01000022.1 Lanthipeptides: BFG57_RS18360_lanthipeptide

Lanthipeptides: BFG57_RS18365_lanthipeptide

GSGWFATITDDCPNSVFVCC

G GW +TITDDCPNS+ VCC

GDGWISTITDDCPNSIIVCC

68.2%

NZ_MOWR01000001.1:

Lanthipeptides: BMI76_RS01705_lanthipeptide

KGSGWFATITDDCPNSVFVCC

+ GW TITD+CPNSVFVCC

RWYGWSFTITDECPNSVFVCC

MIBiG 4.0 matches for E9727_RS05510

17.4%

BGC0002111.3 (EVG22_32245):

Lanthipeptide: andalusicin A or andalusicin B

GWFATITDDC

W +TI+++C

AWASTISNNC

allorf_030287_030358

Leader:

MFIFCKNKQKMLTFMFGG

Core:

CMIRS

Core with dehydrations:

CysMIRDha

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.03 out of 26.06

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.28 out of 29.38

Confidence: medium

Additional weak hits (4):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 20.57 out of 30.22

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.44 out of 39.62

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.35 out of 19.52

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.24 out of 32.74

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

E9727_RS05510 - Class II

Cleavage pHMM score: 4.40

RODEO score: 0

Monoisotopic mass: 2305.1 Da

Molecular weight: 2306.6 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2324.6 Da N = 1

allorf_030287_030358 - Class II

Cleavage pHMM score: -6.10

RODEO score: 0

Monoisotopic mass: 590.3 Da

Molecular weight: 590.8 Da

Number of bridges: 1

TFBS definitions

Regulator	Description
FuR variant 1	Ferric Uptake Regulator
MogR	Repressor of flagellar motility genes

NZ_CAAHMR010000004.1 - Region 1 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 84,534 - 105,406 nt. (total: 20,873 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: synthetase

E9727_RS07115: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002698.2	0.40	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000487.5	0.36	ribosomal	carnocyclin	Carnobacterium maltaromaticum
BGC0000542.3	0.33	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000541.5	0.33	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000502.5	0.33	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0001859.4	0.32	other (phosphonate)	fosfomycin	Pseudomonas syringae
BGC0000617.5	0.32	ribosomal	coagulin	Bacillus coagulans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002698.2	0.40	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000487.5	0.36	ribosomal	carnocyclin	Carnobacterium maltaromaticum
BGC0000542.3	0.33	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000541.5	0.33	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000502.5	0.33	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0001859.4	0.32	other (phosphonate)	fosfomycin	Pseudomonas syringae
BGC0000617.5	0.32	ribosomal	coagulin	Bacillus coagulans

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

E9727_RS07115: PT_FPPS_like

Domain 1 (25 - 272): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

Binding sites found:

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.93 out of 26.33

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.16 out of 20.97

Confidence: medium

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.00 out of 26.85

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.26 out of 27.78

Confidence: medium

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 26.23 out of 28.14

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.55 out of 23.79

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.54 out of 28.19

Confidence: medium

Additional weak hits (6):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.95 out of 39.62

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.76 out of 27.55

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.77 out of 28.14

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.13 out of 25.75

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.81 out of 30.25

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.75 out of 33.14

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
IolR	Regulator of the inositol catabolism
PerR	Peroxide regulator
RutR	Regulator of the pyrimidine and purine metabolism
ZuR variant 1	Zinc-responsive repressor