LOCUS       NZ_CAAHMR010000003     22835 bp    DNA     linear   CON 11-MAY-2024
DEFINITION  Streptococcus pyogenes strain Bra016, whole genome shotgun sequence.
ACCESSION   NZ_CAAHMR010000003
VERSION     NZ_CAAHMR010000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (03-APR-2019) WTSI, Pathogen Informatics, Wellcome Trust
            Sanger Institute, CB10 1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900984225.1-RS_2024_05_11
            Annotation Date                   :: 05/11/2024 02:59:40
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,760
            CDSs (total)                      :: 1,704
            Genes (coding)                    :: 1,661
            CDSs (with protein)               :: 1,661
            Genes (RNA)                       :: 56
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 47
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 43
            CDSs (without protein)            :: 43
            Pseudo Genes (ambiguous residues) :: 0 of 43
            Pseudo Genes (frameshifted)       :: 22 of 43
            Pseudo Genes (incomplete)         :: 20 of 43
            Pseudo Genes (internal stop)      :: 16 of 43
            Pseudo Genes (multiple problems)  :: 13 of 43
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:18:04
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 10152
            Orig. end                         :: 32987
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CAAHMR010000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22835
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22835
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22835
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12835](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12835)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    189..204
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 20.57"
                     /tool="antismash"
     misc_feature    complement(654..667)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 24.03"
                     /tool="antismash"
     gene            911..2491
                     /locus_tag="E9727_RS05470"
                     /old_locus_tag="SAMEA3919085_01090"
     CDS             911..2491
                     /EC_number="2.1.1.72"
                     /GO_function="GO:0009007 - site-specific
                     DNA-methyltransferase (adenine-specific) activity [Evidence
                     IEA]"
                     /GO_function="GO:0015666 - restriction
                     endodeoxyribonuclease activity [Evidence IEA]"
                     /GO_process="GO:0006306 - DNA methylation [Evidence IEA]"
                     /GO_process="GO:0009307 - DNA restriction-modification
                     system [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982804.1"
                     /locus_tag="E9727_RS05470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_01090"
                     /product="type I restriction-modification system subunit M"
                     /protein_id="WP_014407840.1"
                     /transl_table=11
                     /translation="MAEKTTSLRQALWHSADQLRGQMDANDYKNYLLGLIFYKHLSDKL
                     LLAVCDNLEKHFNTFTEAQKIFEDAYQDEGLKDDLISVVTGDLGYFIEPTLTFEKLIQD
                     VYHNTFQLESLAQGFRDIEQSGEDFENLFEDIDLYSKKLGSTPQKQNQTISNVMKTLNE
                     IDFEAVDGDTLGDAYEYLIGEFASESGKKAGEFYTPQAVSHLMTQIVFLGREDQKGMTL
                     YDPAMGSGSLLLNAKKYSNQSDTVSYYGQEINTSTYNLARMNMMLHGVAIENQHLSNAD
                     TLDADWPTDEPTNFDGVLMNPPYSLKWSATAGFLTDPRFSSYGVLAPKSKADFAFLLHG
                     FYHLKNTGTMAIVLPHGVLFRGAAEGKIRQKLLEQGAIDTIIGLPSNIFYNTSIPTTII
                     ILKKNRTNKDVFFIDASKEFDKGKNQNTMTDSHIKKILDAYKSRDNSDKFSYLASFDEI
                     IENDYNLNIPRYVDTFEEVPVKPLPELAKQLSDIDQEIAKTNAKLDQLMKQLVGTTKEA
                     QDELDTFRN"
     gene            complement(2706..2906)
                     /locus_tag="E9727_RS09350"
                     /pseudo=""
     CDS             complement(2706..2906)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002988115.1"
                     /locus_tag="E9727_RS09350"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPDMKSFLNLVKQKLFKPGLKKLVKLHNSQNVNICLYINDWN"
     gene            complement(3048..3653)
                     /locus_tag="E9727_RS05480"
                     /old_locus_tag="SAMEA3919085_01091"
     CDS             complement(3048..3653)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057302.1"
                     /locus_tag="E9727_RS05480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_01091"
                     /product="response regulator transcription factor"
                     /protein_id="WP_011054995.1"
                     /transl_table=11
                     /translation="MKILLIDDHRLFAKSIQLLFQQYDEVDVIDTITSHFNDVTIDLSK
                     YDIILLDINLTNISKENGLEIAKELIQSTLHLKVVMLTGYVKSIYRERAKKVGAYGFVD
                     KNIDPKQLISILKKVDSGKKYFEQIESQDYVESLTDQEIAILNLSKKGFSIKEIEETLQ
                     ISRRTVFNHLTHIYSKLLVNNKQEAIYKAEQLGYFMDF"
     gene            complement(3634..5196)
                     /locus_tag="E9727_RS05485"
                     /old_locus_tag="SAMEA3919085_01092"
     CDS             complement(3634..5196)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000619317.1"
                     /locus_tag="E9727_RS05485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_01092"
                     /product="hypothetical protein"
                     /protein_id="WP_136022232.1"
                     /transl_table=11
                     /translation="MIRIKNITKSKFFGTAIILLQQLIALLILVYNRENLSLLFSEKVA
                     LVMTLIDTAFIWLATILRQKQGDIFKRIISIISLTIWQYLVSVLTRGTPLFLSSGLQII
                     LLYCYTVEITNLILYGHKQFKDKLDKGLLIIIFVSITSLFVNRILFNFLFLMVFTILHL
                     YPLLVIVLYYRSFRQQISVVRRSLILFSLLLLVILGSELYGEMLDVNQAFNNLGWYLFP
                     LIMSVIYYFKTIHDKLSFVTQRWLGDYKARIELLFLLLILCWVVLIKVLVKEFLLFFII
                     VDASTLFCLVVISCIFYYLENSKQNFDYENRRLNYFMKSEENMRVEFLNYLHDDVLQNI
                     IAIKNLLSLENSNITHGFIVNELNDLVSGIREEIDTYHPIVPANQTMKENIQSLFDDIV
                     KSRKSNTLLYFNCSDNMVVPSPYGDIVYRFIKELINNAIKYGDGKDIRLSLTIQSDIII
                     IEESNQVVEKVHSISYGRGLKSFQETLAAFDGDLELQMDTKQFTIRILLPIDWKLCYED
                     FIN"
     misc_feature    complement(5162..5182)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 26.44"
                     /tool="antismash"
     gene            complement(5236..7143)
                     /locus_tag="E9727_RS05490"
                     /old_locus_tag="SAMEA3919085_01093"
     CDS             complement(5236..7143)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1243: ABC
                     transporter, permease component"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012561001.1"
                     /locus_tag="E9727_RS05490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_01093"
                     /product="FtsX-like permease family protein"
                     /protein_id="WP_002982791.1"
                     /transl_table=11
                     /translation="MIWSITKSNIKKNFSLYRIYFLATIGLLSIFIAFLNFISDKIITE
                     KIGDSGQALVIANGSLIFLIVFLVVFLIYFNNFFVKKRSQELGVLAILGFSKRELTKLL
                     TLENLVILVLSYLVSLLLGPTLYFLAVLAITHLLELTLEVQWFITANEIIESLGILVVV
                     FLINVITNGLIISKQSLIEFVNFSRKAEKKIKIRKVRAITAITALLLSYILCLATVFSP
                     TRNMLLSIGMVPVSLLIIVLVVLGTVFTIRYGLAFVVSLLKGNKKRLYRPLSNIIYPKF
                     NYRIATKNKLLTVLGGLLTVTVSVAGMMVMLYAYSLNGIERLTPSAIEYNVESENGQVN
                     VTTILENDQVSLVDVDLLRLNTNPEVTITESGQTIPYFDIINYSDYKELMKAQGRINSI
                     EGSKSLPLLINYYPTEISLGKTFNLGNAYDVTVKQVSTHNVFSFSTSVTTLVVSDKLYA
                     KLSSCFPEKEMTIRTFNGTSIRSSEAFYNQFSMVPDVISSYSKEYTVKTANIATYIFIT
                     FLSILFIICTGSILYFTSLIEIMENKEEYGYLSKLGYSKKMIHRILRYETGILFLIPVF
                     IGIVNGGMLLIYYKYLFMDTLVAGNIIMLSLLLCLLFFLIIYGTFYVLTLRSVTSIIKN
                     "
     gene            complement(7145..7882)
                     /locus_tag="E9727_RS05495"
                     /old_locus_tag="SAMEA3919085_01094"
     CDS             complement(7145..7882)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000812013.1"
                     /locus_tag="E9727_RS05495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_01094"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_002982788.1"
                     /transl_table=11
                     /translation="MKQLVLKDVCKKYPNQLNYALDHINLTVRKGEFVAVMGRSGSGKT
                     TLLNVTSIIDKIDSGNIYCADKEISVFSDNEATSFRKNDIGFVFQDYMLLDSLTIRENI
                     SVALSLKNIDSSKIDDLINSYAKRFNLYEQLKKYPYQLSGGQRQRVSIIRAIIKEPEII
                     FADEPTGALDLKSSEETMMILSEINKTEKVTILMVTHDVLSASYADRVILLKDGKLHME
                     IDKKDCGESFYDVISQALSDRGE"
     gene            complement(7879..10023)
                     /locus_tag="E9727_RS05500"
                     /old_locus_tag="SAMEA3919085_01095"
     CDS             complement(7879..10023)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002887183.1"
                     /locus_tag="E9727_RS05500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_01095"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_136022233.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 3.5e-23, bitscore:
                     75.8, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKITPIEQTTPTECGLCCLYMMLDYFDIPETYFKLKQQVNLGRN
                     GLSIKNISDIASIYGVTCKTYRFSKYPENLPVMVFVSDSHFVILEDIRDDAFTIVDPAV
                     GKYVLAKNEFFELSPKFYTEFFYDKATNSSKKIAKRGLVGRNVKEMIFVNRKDTFLTIL
                     YTLIFQIITVSIPFFIRGIIDGNWVFLKKFGYLESAVLLSIIIFFQGGFYFLKNISLVK
                     LQNKFHSTISEKFVTKLLKLPIEYIGKIDKTDIIHRYNGLMIVRELLSERIISIWLDII
                     LMFASISYITYVSTPLGVILGIVFIVEMMIFFLSLSIKQEKLGKEVLRQKNSLQTFFSL
                     MDGLFLFKAKNSEKELLSKWDKSFKDYINSTYDRNRYFNLLGAVNYVITFSIPILLILL
                     FLYYSPNSSSGELILLYMMVLNFINPINNILNSIDEILYGVKHYERVLEISTLDDETNG
                     TYKLSEDTDIEINLENINYQYELNGAEVLNGINLKVHSGEFVAIIGKSGSGKTTLAKML
                     LGYVSPSSGDITYNNISYSKIDKTDFRNISAFVSQDSPIFDGDVMYNISLGRESVSGEQ
                     VIETCKRVSLYEDIRSMPMKFHTPLFRDNPSLSGGQKQRISLARELVTTPRILVLDEPT
                     SALDVKTERIIQKNVEALHCTRVLVTHRLNTVEKADKILIMDNGKIIDYGNHHYLYKNN
                     KDYCDLYDSYMNKYQEEEAK"
     gene            complement(10001..12835)
                     /gene="lanM"
                     /locus_tag="E9727_RS05505"
                     /old_locus_tag="SAMEA3919085_01096"
     CDS             complement(10001..12835)
                     /GO_process="GO:0009403 - toxin biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0018193 - peptidyl-amino acid modification
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="lanM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032491806.1"
                     /locus_tag="E9727_RS05505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_01096"
                     /product="type 2 lanthipeptide synthetase LanM"
                     /protein_id="WP_134984700.1"
                     /sec_met_domain="DUF4135 (E-value: 2e-83, bitscore: 274.5,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.6e-80, bitscore:
                     263.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKRNELKLEYQQHQFYEYFNSIFDYDILDTSISENIYLLREKTH
                     KLFYSEFENQLFETIMFLSMKTLVLDINHFSKEIENKSKAYEQYIQQIREENGISNFFD
                     RYPYLLKQINREVGLVVESYSLLFDRFLKDLSEIRSCFNITESLSNVEFSLGDSHSQKQ
                     TVVKIEFKGKSVYYKPKSYDSYNILLELISLLKSNNIPSFSLPESLIKADYCWQLGVAY
                     TSSNKDEVAKIYFKYGVLAAFSEIFSITDLHMENVIVSGGDLYLIDVETFFQRKLNVQN
                     QNFEGITVDTYQRIYKTSLSNGLFPVQFEKNSAPNVSGISGKGGKRKKGKYELINKNRG
                     DMKLVKTDYFQEDGYNIPTLNGKVVEPLDYANEVIAGFRECYTFLMSQRAKVKKILEDF
                     PKLKTRAIFRNTSDYGKFLQASTNPKYLFSEKKRENLFSILHESKHIEQFIVVSEIKDL
                     MNGDIPYFSMDTSGNVYNSLGTVIGNLGETTSLFDNIVTLNDERMKFTCELLGIVLKKP
                     IKHWEREKGKSYQFLSISSEHNFSEEILDSIRRIFIDADKNSFSSEEEITWLNIDITET
                     EQWVISPQNITLYNGLIGNALGYLYAYQILGEEQYLVSLNKILKTLETTKNLIETSDMS
                     VFLGKGGLIYLYFSLWKRLKLPQYQKLYLDIIKEFSSQSLEEQNIDYISGVSGLLVVLC
                     NIYNVEQNKTVYHLINRISEFIIDNVKKEDDKVYWVSDFSDSEILNGLSHGQSGIAYAL
                     LLSWKINKNYSYFKIAKSAIDFENTRISDGNWIDFRNKGKRSELGMPEPIYWCHGATGI
                     GLTRYRESKWLNDKELKNNYEMAKQTVLNNGYLNSDCLCHGKMGNMELFMNLDDSLKNE
                     VDIEGIILNIVRNSQKFGWESGLPQHTRVFNMMVGEIGIAYQLLRYISNYEVPSLLLLD
                     VPKGSIENEKDYTD"
     gene            complement(12917..13072)
                     /locus_tag="E9727_RS05510"
                     /old_locus_tag="SAMEA3919085_01097"
     CDS             complement(12917..13072)
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) lacticin_mat"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982773.1"
                     /locus_tag="E9727_RS05510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_01097"
                     /product="type A2 lanthipeptide"
                     /protein_id="WP_002982773.1"
                     /sec_met_domain="L_biotic_A (E-value: 9.6e-20, bitscore:
                     64.1, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="lacticin_mat (E-value: 7.2e-07, bitscore:
                     23.0, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFMKNSKDILTNAIEEVSEKELMEVAGGKKGSGWFATITDDCPN
                     SVFVCC"
     CDS_motif       complement(12986..13072)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSFMKNSKDILTNAIEEVSEKELMEVAGG"
                     /locus_tag="E9727_RS05510_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(12917..12985)
                     /prepeptide="core"
                     /locus_tag="E9727_RS05510_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="4.40"
                     /molecular_weight="2306.6"
                     /monoisotopic_mass="2305.1"
                     /core_sequence="KKGSGWFATITDDCPNSVFVCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSFMKNSKDILTNAIEEVSEKELMEVAGG"
                     /leader_location="[12985:13072](-)"
                     /alternative_weights="2324.6"
     gene            complement(13575..14981)
                     /gene="lacG"
                     /locus_tag="E9727_RS05515"
                     /old_locus_tag="SAMEA3919085_01098"
     CDS             complement(13575..14981)
                     /EC_number="3.2.1.85"
                     /GO_component="GO:0009341 - beta-galactosidase complex
                     [Evidence IEA]"
                     /GO_function="GO:0004565 - beta-galactosidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006012 - galactose metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="lacG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002290548.1"
                     /locus_tag="E9727_RS05515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_01098"
                     /product="6-phospho-beta-galactosidase"
                     /protein_id="WP_002992329.1"
                     /transl_table=11
                     /translation="MTKTLPKDFIFGGATAAYQAEGATHTDGKGPVAWDKYLEDNYWYT
                     AEPASDFYNRYPVDLKLSEEFGVNGIRISIAWSRIFPTGKGEVNPKGVEYYHNLFAECH
                     KRHVEPFVTLHHFDTPEALHSDGDFLNRENIEHFVNYAEFCFKEFSEVNYWTTFNEIGP
                     IGDGQYLVGKFPPGIQYDLAKVFQSHHNMMVSHARAVKLFKDSGYSGEIGVVHALPTKY
                     PFDANNLDDVRAAELEDIIHNKFILDATYLGKYSDKTMEGVNHILEVNGGELDLREEDF
                     TALDAAKDLNDFLGINYYMSDWMQAFDGETEIIHNGKGEKGSSKYQIKGVGRRKAPVDV
                     PKTDWDWIIFPQGLYDQIMRVKADYPNYKKIYITENGLGYKDEFVDNTVYDDGRIDYVK
                     KHLEVISDAISDGANVKGYFMWSLMDVFSWSNGYEKRYGLFYVDFETQERYPKKSAYWY
                     KKVAETQVIE"
     gene            complement(15054..16751)
                     /locus_tag="E9727_RS05520"
                     /old_locus_tag="SAMEA3919085_01099"
     CDS             complement(15054..16751)
                     /EC_number="2.7.1.207"
                     /GO_component="GO:0019197 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase complex [Evidence IEA]"
                     /GO_function="GO:0015155 - lactose transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285167.1"
                     /locus_tag="E9727_RS05520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_01099"
                     /product="lactose-specific PTS transporter subunit EIIC"
                     /protein_id="WP_134984701.1"
                     /transl_table=11
                     /translation="MNGLIAQIEKGKPFFEKISRNIYLRAIRDGFIAGMPVILFSSIFI
                     LIAYVPNAWGFHWSKDIENLLMTPYNYSMGILGLFVAGTTAKALTDSMNRSLPSTNQIN
                     FMSTMLAAIVGFLLMAANPAKEGGFLTGFMGTKGLLTAFIAAFITVNVYKTCVKNNVTI
                     RMPEEVPPNISQVFKDLIPFTLSVVLLYVIELMVHTTLGVNVAESIGKLLAPLFQAADG
                     YVGITIIFGAFAFFWFVGIHGPSIVEPAIAAITYANAETNLQLLQAGEHADKILTSGTQ
                     MFIVTMGGTGATLVVPFMFMWLTKSKRNKAIGRASVVPTFFGVNEPILFGAPLVLNPIF
                     FIPFILAPIVNVWIFKFFIDTLGMNSFTANLPWTTPAPLGLILGTNFQVLAFILAALLI
                     VVDVIIYYPFLKVYDEQILTEEAAGTNSSDALKEKVAANFDTKKADAILEKSAAKETKE
                     ITDQTNVLVLCAGGGTSGLLANALNKAAKEYGAPVTAAAGSYGAHREILPQYQLVILAP
                     QVASNYEDMKVETDKLDIKLAKTEGAQYIKLTRDGQGALDFVKEQMEK"
     gene            complement(16751..17068)
                     /locus_tag="E9727_RS05525"
                     /old_locus_tag="SAMEA3919085_01100"
     CDS             complement(16751..17068)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730102.1"
                     /locus_tag="E9727_RS05525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_01100"
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="WP_002982760.1"
                     /transl_table=11
                     /translation="MNREETTLLGFEIVAYAGDARSKFLEALKAAQEGDYAKAEELIAA
                     GSDCLNDAHNAQTSLLQKEAAGDDLAYSVTLMHGQDHLMTTILLQDLMKHMIELYKRGA
                     K"
     gene            complement(17092..18075)
                     /gene="lacD"
                     /locus_tag="E9727_RS05530"
                     /old_locus_tag="SAMEA3919085_01101"
     CDS             complement(17092..18075)
                     /EC_number="4.1.2.40"
                     /GO_function="GO:0009025 - tagatose-bisphosphate aldolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019512 - lactose catabolic process via
                     tagatose-6-phosphate [Evidence IEA]"
                     /codon_start=1
                     /gene="lacD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017768297.1"
                     /locus_tag="E9727_RS05530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_01101"
                     /product="tagatose-bisphosphate aldolase"
                     /protein_id="WP_111711469.1"
                     /transl_table=11
                     /translation="MTITLTENKRKSMEKLSIDGVISALAFDQRGALKRMMAQHQTKEP
                     TVEQIEELKSLVSEELTPFASSILLDPEYGLPASRVRSEEAGLLLAYEKTGYDATTTSR
                     LPDCLDVWSAKRIKEAGAEAVKFLLYYDIDGDQDVNEQKKAYIERIGSECSAEDIPFYL
                     EILTYDEKIADNASPEFAKVKAHKVNEAMKVFSKERFGVDVLKVEVPVNMKFVEGFADG
                     EVLFTKEEAAQAFRDQEASTDLPYIYLSAGVSAKLFQDTLEFAAESGAKFNGVLCGRAT
                     WAGSVKVYIEEGPQAAREWLRTEGFKNIDELNKVLDKTASPWTEKM"
     gene            complement(18079..19008)
                     /locus_tag="E9727_RS05535"
                     /old_locus_tag="SAMEA3919085_01102"
     CDS             complement(18079..19008)
                     /EC_number="2.7.1.144"
                     /GO_function="GO:0009024 - tagatose-6-phosphate kinase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019512 - lactose catabolic process via
                     tagatose-6-phosphate [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1276: PfkB domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018379688.1"
                     /locus_tag="E9727_RS05535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_01102"
                     /product="tagatose-6-phosphate kinase"
                     /protein_id="WP_111711470.1"
                     /transl_table=11
                     /translation="MILTVTLNPAIDVSYPLDELKCDTVNRVVDVTKTPGGKGLNVSRV
                     LNEFGETVKATGCIGGESGDFIINHLPDSILSRFYKISGDTRTCIAILHEGNQTEILEK
                     GPMLSVDEIDGFTHHFKYLLNDVDVVTLSGSLPAGMPDDYYQKLIKIANLNGKKTVLDC
                     SGNALEAVLKGDSKPTVIKPNLEELSQLLGKEMTKDFKALKAVLQDELFEGIEWIIVSL
                     GADGVFAKHKDTFYNVDIPKIEIVSAVGSGDSTVAGIASGLANDEDDRALLTKANVLGM
                     LNAQEKTTGHVNMANYDKLYQSIKVKEV"
     gene            complement(19056..19571)
                     /gene="lacB"
                     /locus_tag="E9727_RS05540"
                     /old_locus_tag="SAMEA3919085_01103"
     CDS             complement(19056..19571)
                     /EC_number="5.3.1.26"
                     /codon_start=1
                     /gene="lacB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012027025.1"
                     /locus_tag="E9727_RS05540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_01103"
                     /product="galactose-6-phosphate isomerase subunit LacB"
                     /protein_id="WP_134984703.1"
                     /transl_table=11
                     /translation="MKIAVGCDHIVTYEKIAVVDYLKSQGHEIIDCGTYDNVRTHYPIF
                     GKKVGEAVASGKAELGVVICGTGVGITNAVNKVPGIRAALVRDMTSAIYSKEELNANVI
                     GFGGKIIGGLLMNDIIDAFLAAEYKPTEENKKWIEKMDSLQHASQDQNTPHFFDEFLEK
                     WDRGEYHD"
     misc_feature    19537..19552
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.35"
                     /tool="antismash"
     gene            complement(19606..20034)
                     /gene="lacA"
                     /locus_tag="E9727_RS05545"
                     /old_locus_tag="SAMEA3919085_01104"
     CDS             complement(19606..20034)
                     /EC_number="5.3.1.26"
                     /codon_start=1
                     /gene="lacA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982747.1"
                     /locus_tag="E9727_RS05545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_01104"
                     /product="galactose-6-phosphate isomerase subunit LacA"
                     /protein_id="WP_014635709.1"
                     /transl_table=11
                     /translation="MAIIIGADKAGQELKEVIKDYLKEGKHEVVDVSENEVRDFVDTTL
                     AVAKEVNASEDNLGIVIDAYGVGSFMVATKIKGMVAAEVSDERSAYMTRGHNNARIITL
                     GSEISAPGIAKNIIKGFVEGKYDGGRHQVRVDMLNKMC"
     misc_feature    complement(20020..20035)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: medium, score: 24.28"
                     /tool="antismash"
     CDS             complement(20135..20206)
                     /gene="allorf_030287_030358"
                     /locus_tag="allorf_030287_030358"
                     /protein_id="allorf_030287_030358"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MFIFCKNKQKMLTFMFGGCMIRS"
     CDS_motif       complement(20153..20206)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MFIFCKNKQKMLTFMFGG"
                     /locus_tag="allorf_030287_030358_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(20135..20152)
                     /prepeptide="core"
                     /locus_tag="allorf_030287_030358_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.10"
                     /molecular_weight="590.8"
                     /monoisotopic_mass="590.3"
                     /core_sequence="CMIRS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MFIFCKNKQKMLTFMFGG"
                     /leader_location="[20152:20206](-)"
     gene            20479..21252
                     /locus_tag="E9727_RS05550"
                     /old_locus_tag="SAMEA3919085_01105"
     CDS             20479..21252
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004270277.1"
                     /locus_tag="E9727_RS05550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_01105"
                     /product="DeoR/GlpR family DNA-binding transcription
                     regulator"
                     /protein_id="WP_023605292.1"
                     /transl_table=11
                     /translation="MKKKERHEKILDILKVDGFIKVKDIIDEMNISDMTARRDLDTLAD
                     KGLLIRTHGGAQYLDYSSAKDEGHEKTHTEKKVLQTTEKKQIAQRAKNIIKDGETVFIG
                     PGTTLEHLAVELKNRNIRVITNSLPVFLLLHPSTTIDLILIGGECREVTGAFVGAIAIN
                     NLETLTFSKAFVSANAVYNNSIATYSDLEGEVQRVALNNAVEKILLVDSTKFESYDFYN
                     FYQLDQVDLIVTDKNVTTDIIEKYKKFSKIIIADK"
     misc_feature    complement(21810..21828)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 23.24"
                     /tool="antismash"
     gene            21902..22189
                     /locus_tag="E9727_RS05555"
                     /old_locus_tag="SAMEA3919085_01106"
     CDS             21902..22189
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000255538.1"
                     /locus_tag="E9727_RS05555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_01106"
                     /product="DNA-damage-inducible protein J"
                     /protein_id="WP_002988079.1"
                     /transl_table=11
                     /translation="MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVV
                     VTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQGKFYTSEEVRAELGL"
     gene            22179..22514
                     /locus_tag="E9727_RS05560"
                     /old_locus_tag="SAMEA3919085_01107"
     CDS             22179..22514
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003048651.1"
                     /locus_tag="E9727_RS05560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_01107"
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_014635711.1"
                     /transl_table=11
                     /translation="MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDI
                     EKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKDYIVLYHIEGEENRVVIDYLLPTRS
                     DYIKLFK"
ORIGIN
        1 aaattatcat gttattattg ggcgtggagt tgctgctata aaaggtaatg aatttatctt
       61 tcaaatatta aaatacttga aagaaattgg ttattggaaa agaattagta caggttcaac
      121 ttttgatagc attagctcta gtaatatcaa atatgctaaa attcaaattc cctccctccc
      181 cgaacaagaa gctattggcg aacttttcca aacggttgag caattgattc agttgcagga
      241 tcaaaagcta gcaactctaa aagaacaaaa gcaaaccttc ctcagaaaga tgttcccagc
      301 tcaaggacaa aaagtccctg aaatccgttt acaaggtttt gatggtgagt gggaagagaa
      361 gaaattggga gagatatctc ggatgttttc aggtggtact cctagcgtag gtatttctga
      421 atactataac ggtaatattc ctttcattag atcttctgag attaatagtg atcaaacaga
      481 gttatttatc acaaacaaag gtctatcaaa ttcatcagca aaaatagtgg aaaaaaatac
      541 attattatac gctctctacg gtgcaactag tggagaagtt ggactttcaa gaataagtgg
      601 agctattaat caagcaattt tagccattat tcctgagaaa aaatattctt ctctttttat
      661 aaaaaattgg ttatataaac aaaaatcttc aattattgag aaatatttac agggtggtca
      721 aggaaattta tctggttcca ttgtgaaagg attagagctt tatctaccct ccctccccga
      781 acaagaagcc atcggtgact tcttccaaac cctagaccaa caaatgagtc aaatcgaaga
      841 taaattaaca gaacttaaag cactcaaaca aacattactc aatcgtttat tcgtataaga
      901 aaggactcac atggcagaga aaacaacttc actccgtcaa gcactatggc attcggccga
      961 ccaattacgt ggccaaatgg atgccaatga ctataaaaac tatcttcttg gacttatttt
     1021 ttacaaacac ttatctgata aattactctt ggctgtttgt gataatctag aaaaacactt
     1081 caataccttt acagaggctc aaaaaatctt tgaagatgct tatcaagatg aaggcctaaa
     1141 agatgacctc atttctgttg ttactggtga tttaggttac tttatcgaac caacactgac
     1201 ctttgaaaaa ctcatccaag atgtttatca caatactttc caattagaat cattagctca
     1261 aggttttcgc gatattgaac aaagtggtga agactttgaa aacttatttg aagatattga
     1321 cctctactct aaaaaattag gctctactcc tcaaaaacaa aatcaaacca tttctaatgt
     1381 catgaaaaca ttaaatgaaa ttgactttga ggcagtagat ggggatactt taggcgatgc
     1441 ttatgagtac ttgattggtg aatttgccag tgagtcagga aaaaaagcag gtgagttcta
     1501 taccccacaa gctgtctctc acttgatgac tcagattgtc tttttaggtc gtgaagatca
     1561 aaaaggaatg accctctatg accctgctat gggatctgga tcactccttt taaatgctaa
     1621 gaaatatagt aaccaatccg ataccgtttc ttactatggt caagaaatca atacttctac
     1681 ttataacttg gctcgtatga acatgatgct tcatggcgtt gccatcgaaa accaacactt
     1741 aagtaacgct gataccttgg atgcagactg gccaacagat gagccaacca actttgatgg
     1801 ggtgttgatg aacccacctt attctttgaa atggtcagcg actgctggtt tcttaacgga
     1861 tccacgtttt tcaagttatg gtgtattagc accaaaatca aaagctgact ttgccttttt
     1921 acttcatggt ttctatcatt taaaaaatac aggaactatg gcaattgtct taccacatgg
     1981 tgttcttttc cgtggagctg cagaaggcaa gattcgccaa aaactactcg aacaaggggc
     2041 tatcgatacc attatcggac tcccatcaaa tatcttttat aatacaagca tccctacgac
     2101 tattatcata ttaaagaaga acagaaccaa caaagatgtc ttctttatcg atgcttcaaa
     2161 agagtttgat aaaggcaaaa atcaaaacac aatgacagat agccatatca aaaagatcct
     2221 tgatgcttat aagagtcgtg ataattctga taagttttca tatttagcct catttgatga
     2281 aatcattgaa aatgactata acttaaatat cccacgctat gttgatacct ttgaggaagt
     2341 cccagttaaa ccactgccag aattagctaa acagctcagt gacattgatc aagaaattgc
     2401 caaaacaaat gccaaactag atcaactcat gaaacaacta gtcggaacaa ccaaagaagc
     2461 acaagacgaa ttggatactt ttagaaacta aaagacaaaa aaacaccaca gtagatgatt
     2521 actactgtgg cgttttattt aaaattgagt agtgaacctt tattgagtac ttatcaaaca
     2581 agattctcct tcttcaccta taaatcaaaa tagaatcatc tcatctaact ttactttgtc
     2641 cgtttctttg ttttatttaa aatagttatt tgaagttaca atgatttctc aaacgtttag
     2701 aaagcttaaa cacggttaag agaaattttc aggacaactt ttgatccttc cacaaaaacc
     2761 atggtgcgaa ccataaatta gttccaatcg ttgatatata agcatatatt aacgttctgg
     2821 gagttgtgaa gctttacgag tttttttaga cctggtttaa acaacttttg tttgactaaa
     2881 tttaaaaagc ttttcatatc aggcattgcc ctacttttta taaaagcgtt atctcaatca
     2941 atttcaatca aaaagaactc aaaaacaatg agtttaaatc tgggtattta acaggaaatc
     3001 cctagcaacg acacaagtaa aacttatgtc gtttgattat ctgcaactca gaaatccata
     3061 aaatacccta attgttcggc tttgtagata gcctcttgct tattatttac caaaagcttt
     3121 gagtagatgt gggtcaaatg attaaatact gttctcctac taatttgtaa cgtttcctct
     3181 atttctttta tagagaatcc tttcttactc aaatttaaga tagctatttc ctggtcagtt
     3241 aaagattcaa cataatcctg agattcgatt tgttcaaaat acttttttcc agaatccact
     3301 ttttttaaga tagaaatgag ttgtttaggg tctatatttt tatctacaaa accgtatgct
     3361 cctacttttt ttgccctctc tctatagatt gatttaacat atcctgtcaa cataacaact
     3421 ttcaaatgaa gagtagactg tatgagttct tttgctatct ccaatccatt ttctttagaa
     3481 atatttgtta aattaatatc aagcaatata atatcgtact tagacaaatc aatcgtcaca
     3541 tcgttaaaat gagaagtaat cgtatctatg acatctactt catcatactg ttggaataac
     3601 agttggatac tctttgcaaa tagtctgtgg tcatcaatta ataaaatctt cataacacaa
     3661 tttccaatct atgggaagta atattctgat agtaaattgt ttagtatcca tttgtagttc
     3721 tagatctcca tcaaaagctg ctagtgtttc ttgaaatgat ttcaatcctc tgccataact
     3781 tatagagtgt actttttcca ctacttgatt gctctcctca atgataataa tatcagattg
     3841 aatcgttaaa gataaacgaa tgtcttttcc atctccatat tttatagcat tgtttattag
     3901 ctcttttata aacctataaa caatatctcc atatggggat ggcactacca tattatctga
     3961 acagttaaaa tacaataagg tattactttt tctactttta acaatatcat caaaaagaga
     4021 ctgtatgttt tctttcattg tttgattagc gggaactatt gggtggtaag tatcaatttc
     4081 ttctctgata ccagaaacta aatcattcaa ctcattaaca ataaaaccat gtgttatatt
     4141 actattttct agagaaagca agttttttat cgctatgata ttttgtaaaa catcatcatg
     4201 caaataattt aagaactcca ctctcatgtt ttcctctgat ttcataaaat agttcagtct
     4261 tctattttca tagtcaaaat tttgtttgga gttttctaaa taataaaaga tgcaagaaat
     4321 taccactaga caaaataacg tgcttgcgtc aacaattata aaaaataata aaaattcttt
     4381 aactagtacc tttatgagta caacccaaca aaggataaga agtagaaata atagttctat
     4441 acgagctttg taatcaccta accatctttg ggtaacaaaa ctcaatttat catgtatggt
     4501 cttaaaatag tatattacac tcattataag gggaaacaga taccatccca aattattaaa
     4561 ggcttgatta acatctagca tttctccata aagttcacta ccaagtatta ccagcaaaag
     4621 taaagaaaat agtatcaatg aacgtctaac aactgatatt tgttgcctaa aggacctata
     4681 atatagcact ataactagta acggatacag gtgtaaaata gtaaaaacca tcaggaataa
     4741 aaaattaaat aaaattctat taacaaaaag gctagttata gaaacaaaaa taattattaa
     4801 caagccctta tctaacttat ctttaaattg tttgtgccca tataatatta aattagtaat
     4861 ctcaacggta taacaataga gcaatataat ctgtagtcca ctgcttaaaa agagaggagt
     4921 tcctcttgtc agcacagata ctaagtattg ccaaattgtt aaggagatga tagaaataat
     4981 tcttttaaaa atatcacctt gtttttggcg taatattgtt gccagccaaa taaaagctgt
     5041 atcaataagg gtcattacaa gagctacttt ttcagagaaa agaagagaca ggttctctcg
     5101 attatagacc aaaattaaca aggctattaa ttgttgcaac aagattattg cagtcccaaa
     5161 gaacttactc tttgttatgt tttttattct tatcatatta tttacttaat cgttaaagtt
     5221 aaaagatttt taaaattaat ttttgattat ggatgtcact gaccgcaatg tcaatacata
     5281 aaatgtgcca tatattatca agaagaaaag cagacaaagc aataaagata acattatgat
     5341 attgcctgct accaatgtat ccatgaataa atatttatag taaataagca acataccacc
     5401 atttacaatc ccaatgaata caggaataag gaaaagtata cctgtttcat atcgaagaat
     5461 ccgatgaatc atttttttac tataacctag cttacttaga tagccatatt cttctttatt
     5521 ttccatgatt tcgatgaggc ttgtaaagta cagaatacta cctgtacaaa taataaagag
     5581 tatggatagg aaagttataa agatataagt cgcaatatta gcagtcttta ctgtgtattc
     5641 cttactataa ctactgataa catcaggaac catactaaac tgattgtaaa atgcttcact
     5701 tgacctaatc gaagttccat taaaagtcct aattgtcatt tctttctctg gaaaacaaga
     5761 actaagttta gcatataatt tatcagaaac aaccaaggtc gtgacacttg tagaaaaact
     5821 aaaaacatta tgcgttgata cttgttttac agtaacatca tatgcatttc ctaagttaaa
     5881 ggtttttcca aggctaattt ctgttggata ataatttatt aacaatggga gtgacttact
     5941 accttcaata gaatttattc tcccttgagc tttcattaac tctttataat cactgtaatt
     6001 aattatatca aaataaggaa ttgtttgccc agattctgtg atagttactt ctgggttagt
     6061 gttcaatctc aataggtcaa catcaaccaa gctcacttgg tcgttctcta aaatagttgt
     6121 aacattgact tgaccgtttt ctgattcaac attatattct atggcagatg gagtcaacct
     6181 ctctatccca ttaagagaat aagcatagag cattaccatc attccggcaa ctgaaacggt
     6241 tactgttaaa agacctccca agactgttaa taatttattt tttgttgcaa tacgatagtt
     6301 aaatttggga tagatgatat tagacagagg acggtataac ctttttttat ttccttttaa
     6361 taacgaaact acaaaagcca atccatatct gatggtaaac actgttccca aaacaactaa
     6421 aacaattatc aatagagaaa ccggtaccat ccctatgctt aatagcatat ttcgtgtggg
     6481 tgaaaatact gtcgccaaac ataaaatata tgataatagc aatgcagtaa tagcagtaat
     6541 agctctgact tttcttatct taattttttt ctcagccttt cttgagaaat taacaaattc
     6601 aatcaaagac tgtttactaa tgataagtcc atttgtgatg acattaatca gaaaaactac
     6661 aactaatatt cctaaagact ctataatctc attagctgta ataaaccact gaacttccaa
     6721 tgttaattcc aatagatgag taattgccag tacagctaaa aaatataaag tcggtcccag
     6781 caataaactt accaagtaac tcagaactag aataacaaga ttttctaaag ttagtaattt
     6841 tgttaattct ctttttgaaa accctagtat tgctaagact ccaagctctt gactacgttt
     6901 ttttacaaag aaattattga agtaaattaa gaataccacc aaaaatacaa tcaaaaaaat
     6961 caatgaccca ttagcgataa ctagagcttg accactatcc ccaatttttt ctgtaatgat
     7021 tttatctgag ataaaattta gaaaagctat aaaaatactt aataaaccaa tcgtagctag
     7081 aaaatagata cgatataacg aaaaattttt tttaatgtta gattttgtaa tggaccaaat
     7141 catattactc tcctctatcg gataaagctt gactaattac atcgtaaaac gactctccac
     7201 aatctttttt atcaatctcc atgtgaagtt tcccatcttt gaggagtata actctgtcgg
     7261 cataagaagc tgataaaacg tcatgagtaa ccattaaaat agttaccttt tctgttttat
     7321 tgatttcact caaaatcatc attgtttcct cagaagattt caagtcaagt gctccagttg
     7381 gttcgtcagc aaaaataatc tctggttctt taatgattgc tctgataata ctgaccctct
     7441 gtctttgacc tccagaaagt tgatacggat atttcttcaa ctgttcatat aaattaaatc
     7501 tttttgcata gctatttatc aaatcatcaa tctttgaaga atcaatattt tttagagaca
     7561 aagcaacaga aatattctcc ctaatggtta gactgtctaa cagcatataa tcttgaaaaa
     7621 caaaaccaat atcatttttt ctaaaactag ttgcctcgtt atcagaaaat acactaatct
     7681 ctttatccgc acaataaata ttcccactat caattttatc aataattgaa gtaacattta
     7741 aaagcgtcgt tttcccacta ccgctacgcc ccatgacagc tacaaattct ccttttctaa
     7801 cagtcaaatt gatatggtct agagcataat tcagttgatt gggatatttt ttgcaaacat
     7861 cttttaatac taattgtttc attttgcctc ttcctcctga tatttattca tatacgagtc
     7921 atataagtca caataatcct tattattttt gtacaaataa tgatggtttc catagtcaat
     7981 aattttgcca ttatccatta ttaaaatctt atcagctttt tcaactgtat taagtctatg
     8041 ggtaaccaaa accctcgtac aatgtaaagc ctcaacattt ttttggatta ttctttcagt
     8101 ttttacatct aaagctgatg taggttcgtc aagaactaag attctagggg tagttactaa
     8161 ctctcttgct aaagaaattc gttgtttttg ccccccagat agtgatggat tatctcgaaa
     8221 aagtggagta tgaaacttca ttggcatact cctgatatcc tcatatagtg ataccctttt
     8281 acaagtttca ataacctgtt ctcctgaaac agattctctc cctagcgaaa tgttatacat
     8341 cacatcccca tcaaatatgg gagaatcttg agatacaaaa gccgatatat tcctaaaatc
     8401 agttttatca attttagagt aggatatatt gttgtatgtg atgtctccac tactagggct
     8461 tacatagcct aacaacatct tagctagagt tgtctttcca cttccacttt tccctataat
     8521 tgcaacaaat tctcctgaat ggacttttag gtttattcca tttaacacct ctgccccatt
     8581 taactcatat tgatagttta tattttctaa atttatctct atatctgtat cctctgatag
     8641 cttataagtg ccattcgtct catcatcaag agttgatatc tctaataccc tttcgtaatg
     8701 cttaacacca tatagaatct catcaatcga attcaaaata ttattaatgg gattaataaa
     8761 atttaaaacc atcatataaa gaagaataag ctcaccactg ctactatttg gtgaataata
     8821 tagaaataac agaattaaca aaataggtat ggaaaaagtt atcacataat ttactgctcc
     8881 taaaagattg aaatatctat ttctatcata tgttgaattg atatagtcct taaaactttt
     8941 atcccatttt gacaaaagtt ctttttcaga atttttagct ttaaaaagaa atagcccgtc
     9001 catcagtgaa aaaaatgttt gtaaagagtt cttttgtctt aaaacttctt tacctaactt
     9061 ttcttgttta atgcttagtg ataggaaaaa aatcatcatt tctacaataa aaactatacc
     9121 caatataact cccaaaggtg tagaaacata tgtgatataa ctaatactcg caaacattaa
     9181 gataatatcc aaccagatag aaataattct ttctgatagt aactccctca caatcatcaa
     9241 accattatat ctatgaatga tgtctgtttt atctattttt ccaatatatt ctatgggaag
     9301 tttcaataac ttagtcacaa acttttctga aatagtgctg tgaaatttat tttgcaattt
     9361 cactaaagag atattcttta gaaaataaaa tcctccctga aaaaaaatta ttatagaaag
     9421 taggactgca ctttctaaat agccaaactt tttaaggaaa acccaatttc catcaataat
     9481 tccccttata aaaaatggaa ttgacactgt gataatctga aaaatcagag tatatagaat
     9541 ggttaaaaaa gtatccttcc tatttacaaa tatcatttcc tttacgtttc tgccaactaa
     9601 tcctcgtttg gctatttttt ttgaagaatt agtcgcctta tcataaaaaa attcggtata
     9661 aaatttagga gataattcaa aaaattcatt ctttgctaag acatatttcc caacagcagg
     9721 gtcaacaata gtaaaggcat catcacgaat atcctctaaa attacaaaat gcgaatctga
     9781 aacaaatacc atgacaggta agttttcggg atatttggaa aaacgataag tcttacaagt
     9841 aactccgtag atagaagcaa tatctgagat attctttata ctcagtccat ttctccctaa
     9901 attgacttgt tgtttcaatt taaaatatgt ttctggaata tcaaaataat ctaacatcat
     9961 atataaacaa cataatccac attcagtagg agttgtttgt tcaatcggtg taatcttttt
    10021 cattttcaat actccctttt ggaacatcta ataacaataa tgatggtact tcataattgg
    10081 atatatatct aagtaactgg tatgctatcc ctatttcacc aaccatcata ttaaacactc
    10141 ttgtgtgttg tggcaagcca gattcccaac caaatttttg agaattacga acaatattaa
    10201 gtatgatacc ttctatatct acttcatttt tcaaggagtc atctaaattc ataaataatt
    10261 ccatgttgcc cattttcccg tgacaaaggc aatccgaatt caaataacca ttatttaata
    10321 ccgtttgttt agccatttca taattatttt tcaactcttt atcgtttaac cattttgatt
    10381 ctctatatct cgttaatccg atacctgttg caccatgaca ccaataaata ggttctggca
    10441 ttcctaactc tgaacgtttt cctttatttc taaaatcaat ccaatttcca tcagaaatac
    10501 gggtattttc aaaatcaata gctgacttcg ctattttaaa ataactataa tttttattga
    10561 ttttccatga taaaagtaat gcatatgcaa tcccagattg tccgtgagat agtccattta
    10621 gaatttctga atctgaaaaa tccgataccc aataaacctt atcatcttct tttttcacat
    10681 tatcaataat aaattcagat atcctattaa ttaaatgata tactgtttta ttttgctcta
    10741 cattatatat gttgcacaga acaactaata aaccagacac tccagaaata taatctatat
    10801 tttgctcctc tagtgactgg ctggaaaatt ctttgattat gtctaaatat aatttttggt
    10861 attgaggtaa tttaagtctt ttccacaaac taaagtatag ataaatcaaa cctccttttc
    10921 ccaaaaaaac tgacatatca ctagtttcta taagattctt tgtggtttcc aatgttttca
    10981 atatcttatt taatgatact agatattgct cttcaccaag aatttgataa gcatataaat
    11041 aacctaaggc attcccaatc aatccattat acaaggtaat gttctgagga gatattaccc
    11101 attgctcagt ctctgtaata tcaatattga gccatgttat ctcctcctct gaagaaaagc
    11161 tattcttatc tgcatcaata aatattcgtc taatgctgtc taagatttcc tcactaaaat
    11221 tgtgttctga ggagattgat aaaaactgat aagatttgcc cttttccctc tcccaatgct
    11281 taatcggttt tttcaagact attccaagca attcgcaagt gaacttcatt ctttcatcat
    11341 tcagggtaac tatattatca aataatgagg ttgtctctcc tagatttcca attactgttc
    11401 ctaaagaatt atatacattt ccactggtat ccattgaaaa gtaaggaata tcaccattca
    11461 tcaaatcttt aatttcacta acaacaataa attgttcaat atgttttgac tcatgtagta
    11521 tcgaaaataa attctccctc tttttttctg agaaaagata ttttggattc gtagaggctt
    11581 gtaaaaattt tccatagtcg gaagtatttc tgaatatggc tctagttttc aattttggga
    11641 aatcttctaa aattttttta acctttgcac gttgcgacat aagaaatgta tagcattctc
    11701 taaaacctgc aattacctca ttagcatagt cgagaggttc cactactttc ccatttaatg
    11761 tcggaatatt ataaccatct tcctgaaaat agtcagtttt cactaacttc atatctccac
    11821 gatttttatt tatcagttca tactttccct tttttctttt cccacctttt ccacttatcc
    11881 cagaaacgtt aggagcgctg tttttctcaa attgtacagg aaataaacca tttgaaagtg
    11941 atgtcttata aattctctga taggtgtcta cagtaatccc ttcaaaattc tgattttgta
    12001 cattcaactt tctttgaaaa aaggtttcaa cgtcaattaa atataaatct ccgcctgaaa
    12061 caatcacatt ttccatatgt aagtccgtaa tagaaaatat ttcagaaaat gctgctaaaa
    12121 caccatactt aaagtaaatt ttcgctactt catctttatt ggaacttgta taagctacac
    12181 caagttgcca acaataatcc gctttaatta agctttcagg aagactgaac gaaggtatat
    12241 tattagattt caatagacta ataagttcca acaagatgtt gtatgaatca tagcttttag
    12301 gcttgtagta aacggatttc cctttaaatt caatcttaac gactgtttgt ttttgggaat
    12361 gactgtctcc aagtgaaaat tcaacattac ttaaggactc agtaatatta aagcatgacc
    12421 ttatttcaga caaatctttt aaaaacctat caaatagcaa agagtatgat tccactacca
    12481 atccaacttc tctattgatt tgttttagca aatatggata tctgtcaaaa aaattactta
    12541 tcccattttc ttcccttatc tgctgtatat attgttcata tgcctttgac ttattttcaa
    12601 tttccttgga aaaatgattt atatctagaa ctagtgtttt cattgaaaga aacattatag
    12661 tttcaaataa ctgattttca aactcactat aaaataactt atgtgtcttt tcccttaaca
    12721 gataaatatt ttcactaata gaagtatcta atatgtcgta atcaaaaatt gagttaaagt
    12781 attcgtaaaa ctgatgttgc tgatactcta actttaattc atttcttttt atcatttttt
    12841 cctaccacta cttaaaaatc ctgcctagac taagtctaaa caggaaattt tagtctgctt
    12901 atccagattg ttttaattaa caacaaacaa atactgagtt cggacagtca tcagtaatag
    12961 ttgcaaacca acctgaacct tttttaccac cagctacttc cataagttct ttttcagaaa
    13021 cttcttcgat agcattagtc aaaatatcct ttgaattttt cataaaactc attctccttc
    13081 ctatcagtat gtagtgacta ttttctacac ttttattgta aataatacgt cttcattttc
    13141 aatgagtaaa aagtgcaaaa atgacttttt tcatattttt tagtaagatt tttgagatgt
    13201 cacataagag gtcactttat aacaaatagc cctctgatat aaaaaacaaa actcgttctt
    13261 tacagctatt ttacaatcta atcgcttctc gttataacat caatctctaa tcagaaaatg
    13321 gttactttac ttatttaatc aggtcaggag tttgaatgac agaagtcaaa tatctgaaaa
    13381 aggatgttaa ataaaacttt caaaacccat tttcatcaac taaaaacact tataacccga
    13441 tcttacaact aatggattac catcaacagc aaataatact atgcttgaaa aatgtcaaca
    13501 tcatctactt tttgtgacta taattcagta aacgaacatg acgtgtaaaa atgtattaaa
    13561 gcagtatctc aaaatcattc aatcacttga gtttctgcta cttttttata ccagtaggca
    13621 ctcttcttag gataacgttc ttgagtttca aaatcgacat agaagagacc gtaacgtttt
    13681 tcatagccat ttgaccatga aaagacatcc atcagtgacc acataaagta tcctttaaca
    13741 tttgcaccat cagaaatagc atcagaaata acttctaagt gttttttcac ataatcgata
    13801 cgtccatcat cataaacagt attatctaca aactcatctt tgtaaccaag accattttca
    13861 gtgatataaa ttttcttgta gttaggataa tcagctttaa cacgcatgat ttgatcatat
    13921 agaccttgtg ggaagataat ccagtcccag tccgtttttg gaacatcaac gggtgctttt
    13981 cttcgaccaa cacccttgat ttggtattta gagctgcctt tttcaccctt accattgtga
    14041 atgatttcag tctcaccatc aaaagcttgc atccaatcac tcatatagta gttaatacca
    14101 aggaagtcat tcaaatcttt tgcggcgtct agtgcagtaa aatcttcttc acgaagatca
    14161 agttcaccac cattcacctc aaggatatgg ttaacacctt ccattgtttt atctgaatac
    14221 ttacctagat aagttgcatc aagaataaat ttattatgga tgatatcttc cagttcagct
    14281 gctctaacat catcaagatt gttagcgtca aatggatact tagttggaag agcatggaca
    14341 acgccgattt cacctgaata accactatct ttaaaaagtt tgactgcacg agcatgagag
    14401 accatcatgt tatggtgtga ttggaaaact ttagcaagat catattggat acctggaggg
    14461 aatttaccaa ctaagtattg accatcgcca attggtccaa tttcgttaaa tgttgtccaa
    14521 tagttaactt ctgagaattc tttaaaacaa aattctgcat aatttacaaa atgttcaatg
    14581 ttctcacgat tgaggaaatc accatccgag tggagagctt ctggtgtatc aaaatggtga
    14641 agtgtaacaa aaggctcaac atgacgctta tgacactctg caaaaagatt gtggtagtat
    14701 tctactcctt tagggttaac ttctcctttt cctgttggaa aaatacgaga ccaggcaata
    14761 gagatacgga tcccattaac accaaattct tcactaagtt tcaaatcgac agggtaacga
    14821 ttataaaaat cacttgctgg ctcagctgtg taccaatagt tgtcttctaa gtatttatcc
    14881 caagctactg gtcctttacc atctgtgtgg gtagcgcctt cagcctggta agcagctgta
    14941 gcaccaccaa aaataaaatc tttaggtaat gttttagtca tgatatacct cttctaaatt
    15001 ttcatttcac tataaaggaa gattgagtac ccccaacctt ccctagcgac atattatttt
    15061 tccatttgtt ctttaacgaa gtctaatgcg ccttgaccat cacgggtcaa tttgatgtat
    15121 tgagcccctt ctgttttagc taatttaata tcaagtttat cagtttccac tttcatatct
    15181 tcatagttag aagctacttg aggtgcaagg ataacaagtt gatattgtgg taaaatctca
    15241 cggtgagcac cataacttcc tgctgctgca gtgacaggtg caccatattc tttagctgct
    15301 ttattcaaag catttgctag tagtccactt gtaccaccac cggcacaaag aacgagaaca
    15361 ttagtttgat cagtgatttc tttggtttct ttagctgctg atttttcaag aatagcatca
    15421 gcttttttag tatcaaagtt tgctgctact ttttctttga gggcatctga tgaattcgta
    15481 cctgctgctt cttcagtaag aatttgctca tcatatactt ttaagaatgg gtagtagatg
    15541 atgacatcaa ctacgattaa caaagctgcc aaaatgaatg ctagcacttg gaagtttgtc
    15601 ccaaggataa gacccaatgg agctggtgtt gtccaaggta agtttgcagt gaaactgttc
    15661 attccaagtg tgtcaatgaa gaatttgaaa atccatacgt tgacaatcgg tgccaagata
    15721 aatggaataa agaaaattgg gttcaaaaca agtggagcac caaacaaaat gggttcgtta
    15781 acaccaaaga atgttggaac aactgatgca cgtccaatgg ctttgttacg ttttgatttc
    15841 gtcaaccaca tgaacatgaa tggaacgaca agtgttgcac ctgtaccacc catggtaacg
    15901 atgaacattt gagtccctga agtcaaaatc ttgtcagcat gttcaccagc ttgaagtaat
    15961 tgaaggttgg tttcagcatt tgcgtaagta atcgctgcaa tggctggttc aacaatagat
    16021 ggtccatgaa taccaacaaa ccagaagaaa gcaaatgcac cgaagataat agtgattcca
    16081 acatagccat ctgctgcttg gaacaatggt gcaagaagtt taccaattga ttctgcaacg
    16141 ttaacgccta aagtagtatg aaccatcaat tcaatcacat aaagcagtac aactgataac
    16201 gtaaatggaa tcaaatcctt aaatacttga gagatatttg gtggaacctc ttctggcata
    16261 cggattgtaa cattgttttt cacacaggtt ttatagacat ttacggtaat aaaagctgcg
    16321 atgaaggctg tcaacaaacc ttttgttccc ataaatccag ttaagaaacc accttctttt
    16381 gctggattgg ctgccataag taaaaaacct acaatagcag cgagcatggt agacatgaag
    16441 ttgatttggt ttgtgcttgg taatgatcga ttcattgagt cagttaaagc tttggctgtc
    16501 gtaccagcca caaacaaacc taaaataccc attgagtagt tgtatggcgt catcaagaga
    16561 ttctcaatat ccttactcca atggaagccc catgcatttg gaacataggc aatcaagata
    16621 aagatacttg aaaacaagat aactggcata ccagcgataa aaccatcacg aatagcgcga
    16681 agatagatgt ttcgagaaat tttctcgaag aaaggtttcc ctttctcaat ctgagcaatt
    16741 aatccattca ttattttgct cctctcttat aaagttcaat catgtgtttc attaaatctt
    16801 gtaataaaat ggtcgtcatt aaatgatctt gaccatgcat taaagtgaca ctataagcta
    16861 agtcatctcc agctgcttct ttttgtagta gacttgtctg agcattgtga gcatcattca
    16921 agcagtcact acctgcagcg attaattctt ctgctttagc ataatctcct tcttgcgctg
    16981 ctttaagcgc ttccaaaaat tttgaacggg catcaccagc ataggctacg atttcaaaac
    17041 ctaaaagagt agtttcttct ctattcattg tagtttcctc cgaaaataat gttacatttt
    17101 ttcagtccaa ggacttgcag ttttatctag tactttgttt aattcgtcaa tatttttgaa
    17161 accttctgta cgcaaccatt cacgagctgc ttgtggtcct tcttcgatat agacttttac
    17221 agatcctgcc caggtagcac gtccacataa gacaccgttg aatttagcac ctgattctgc
    17281 tgcaaattcc aaagtatctt ggaacaactt ggctgaaaca cctgcactca agtaaatata
    17341 tggtaaatca gtagaagctt cttgatcacg gaaagcttga gctgcttctt cttttgtaaa
    17401 gagaacctca ccatctgcaa agccttctac aaatttcata tttactggaa cttcaacttt
    17461 caacacgtca acaccaaagc gctcttttga gaaaactttc attgcttcgt taactttatg
    17521 agctttaact tttgcaaact cagggcttgc attgtcagca attttctcat cataagttag
    17581 aatttctaag tagaatggaa tatcttctgc actgcattca gaaccaatac gttcaatgta
    17641 agcttttttc tgctcgttaa catcttgatc tccatcaata tcatagtaaa gaaggaattt
    17701 aactgcttct gctccagctt ctttaatacg ttttgcagac caaacatcta agcaatcagg
    17761 taagcgacta gttgttgttg catcgtatcc tgttttctca tatgccaaca acaagcctgc
    17821 ttcttctgaa cgaacacgac ttgctggcaa gccatattca ggatcaagta aaattgatga
    17881 tgcaaatggt gtcagttctt cagaaactaa acttttaagc tcttcaattt gttctactgt
    17941 tggctctttt gtttgatgtt gagccatcat acgtttgaga gctccacgtt ggtcaaaagc
    18001 taaagcagaa ataacaccat ctatacttag tttttccatg cttttacgtt tgttttcagt
    18061 taaagtaatt gtcatttttt atacctcttt gactttaata gattgatata gcttatcgta
    18121 atttgccatg ttaacatgcc cagttgtttt ttcttgcgca tttaacatcc ctaagacatt
    18181 tgcttttgtt aataaagctc gatcatcttc atcattcgct aaacctgaag caatacctgc
    18241 cactgtagaa tcacccgaac ctacagcgct tacaatttcg attttaggaa tgtcaacgtt
    18301 ataaaacgta tccttgtgct ttgcaaatac accatcagca ccaagagaaa cgattatcca
    18361 ttcaattcct tcaaatagtt catcttgtaa gactgctttt aaagctttaa aatcttttgt
    18421 catttcttta ccaagaagtt gagaaagttc ttcaagatta ggcttgataa ctgttggttt
    18481 actatcacct tttagtactg cttctaaagc atttccagaa caatccagaa ccgttttctt
    18541 accattaaga ttggcaatct tgattaactt ctgatagtaa tcatctggca taccagcagg
    18601 caaactgcct gagagcgtca ctacgtcaac atcattcagt aaatatttaa aatgatgagt
    18661 aaagccatca atttcatcta cacttaacat cggtcctttt tctaaaatct ccgtttgatt
    18721 accttcgtgt aatatggcta tacatgttct ggtatcacct gaaattttat agaagcgact
    18781 taaaatcgaa tcaggaagat gattaatgat aaaatcaccg ctttctccac ctatacaacc
    18841 agtagctttg actgtctcac cgaattcatt aagaactcgg gaaacattca agcctttacc
    18901 accaggtgtc tttgtaacat ctacaactcg attcacggta tcgcatttta gctcatccaa
    18961 agggtaggag acgtcaatag ctggatttaa agtaactgtt aaaatcacaa tagctccttt
    19021 ttctctatat atccctatag taatttattc aaatattagt cgtgatattc accacggtcc
    19081 catttttcta ggaattcatc aaagaagtgt ggggtgtttt gatcttggct agcatgttgc
    19141 aagctatcca ttttttcaat ccatttttta ttttcttcag ttggtttgta ttccgcggct
    19201 aagaaagcat cgataatatc attcatcaat aaaccaccga tgatttttcc accaaaacca
    19261 ataacgtttg cgtttagctc ttcttttgag tagatagcag atgtcatatc tctaacgagt
    19321 gctgcacgaa taccgggaac tttgtttaca gcatttgtga taccaacacc agtaccacag
    19381 ataacaacac ctaattctgc tttaccactt gctactgctt caccaacttt tttaccaaag
    19441 attggatagt gtgtgcggac attatcgtat gtcccgcaat caataatttc atgaccttgt
    19501 gattttaggt aatccacaac agcgattttt tcataagtaa caatatggtc acaacctaca
    19561 gcaattttca tttttgttct ccttgtttta acctatttca atcaattagc acattttatt
    19621 aagcatgtcg acacgaactt gatgacgtcc accatcatat ttaccttcga caaagccttt
    19681 gataatgttc tttgcaattc ctggagcact aatttcagaa ccaagcgtga tgattcgagc
    19741 attgttgtgt cctcttgtca tgtatgctga gcgctcatct gatacttcag ctgccaccat
    19801 tcctttgatt ttagtagcta ccatgaaaga accaacacca tatgcatcaa tgacaatacc
    19861 taagttatct tcggatgcat taacttcttt tgcaacagct aaagttgtat ctacaaagtc
    19921 acgtacttcg ttttcactaa catcaacgac ttcgtgttta ccttctttaa ggtaatcttt
    19981 gataacttct ttaagttctt gacctgcttt gtcagcaccg ataataattg ccattttatt
    20041 tctcctatga tttagaataa gtaaatgtgg aaaacctacg tagatagtta attaacaatt
    20101 tgcaacatct tttgaaataa cgctttcatt atttctatga cctaatcata cacccaccaa
    20161 acataaaagt caacattttt tgtttattct tacaaaaaat aaacaaaaaa tgtttatttt
    20221 tttcgttttt atgttattat cctaatgttt cttgtgtttc ttttccatct tataaatccc
    20281 tttgacagcc actcgtaacc tatcatatat tacgaaaccc ttatctctat ttattgtaaa
    20341 tgttttattt aaaacatttt ctattttgtt aatttttgtt ttttccaatg tttatgtttg
    20401 ttttgtttga tttttttatt gatattatgt tatgatacct ttaatagtta taccctaaga
    20461 cactgatagg agataagaat gaaaaagaaa gagcgtcatg aaaaaattct cgatatctta
    20521 aaagttgacg gttttataaa agtaaaagat attatcgatg aaatgaacat ctcagatatg
    20581 accgctagac gagatctcga tacattggca gataaaggat tacttatcag gacccatggt
    20641 ggtgctcaat atttggatta ttcttcagca aaggacgaag gtcacgagaa aacacacact
    20701 gaaaagaagg tcttacagac taccgaaaaa aaacaaattg cacaaagagc taaaaacatt
    20761 attaaagatg gcgaaactgt ctttataggt ccagggacaa cattagagca tctagctgtc
    20821 gaattaaaaa atagaaatat cagggtcatt acaaatagcc ttcctgtttt tttacttttg
    20881 cacccgagca ctactattga tttgatttta attggtggtg aatgtcgtga agttactggt
    20941 gcttttgttg gtgctattgc cattaataac ctagaaacat taacattttc aaaggctttt
    21001 gttagcgcaa acgcagttta caataattct attgcaacgt acagtgatct cgaaggagaa
    21061 gttcaaaggg tcgccttgaa taatgctgtt gagaaaatcc ttctagttga tagtaccaag
    21121 tttgaaagtt atgacttcta taatttctac caactagatc aagtggactt aattgtgact
    21181 gataaaaatg tgacaactga tatcatagaa aagtacaaga aattctcaaa aatcataatc
    21241 gctgacaagt aaaggaccta ctcatattaa aaagcacttc agggtttaga tatatcccct
    21301 gtcaagtaaa cagggagcat atctgaaagt agtgtttgtg ttataaagaa gtttcttgtt
    21361 aacttatttt ctggtttttt tcagacttat cagtcttgta ctgttccttt ttctgatgaa
    21421 taacgtggaa ataggcagac agctatatat ttcacctcta gaatggttgt cattactgtc
    21481 atcaagacat gcttgttctt tatcgtatgg agtgaagctt tcttttagac atcaaaatac
    21541 ctcttaagta gattttcgtt cgttaccatg tctacttaag aggtgtcttc aaagcgcttt
    21601 aaaacgttga tataacagta tattaacgtt ttgagaattg tgaagcttta cgagcttttt
    21661 taagacctgg tttttggttc actccattat ttaaagtcaa atccctttaa aatcaatgtt
    21721 tctaaaatga aaaatcacta aaaatcttat ttatagacaa atacttaaac ctaaacggta
    21781 tcaaaaataa gtttcggagc ttatcaaata atgaaaatct gtctcaatta ccgagtcttt
    21841 tttattaagt tttttgtata tatgatataa ttaaataaat tacataaagg ggttacataa
    21901 aatgactaca gtaaaaaaaa acagagcggt tacctttcaa gctaataaag aattggtaag
    21961 cgaagcaatg acagtattaa acaaaaaaaa tttaacctta tcatctgctt taagattatt
    22021 cctacaaaat gtcgttgtca caaacgaggt tgacttattg acggaagagg agttagagaa
    22081 agaaaaactt ttcaagcaat ttcaagctga aatcaacaaa aatattgagg atgttcgtca
    22141 agggaagttt tatacctctg aagaagtgag ggctgaactt ggactataag aaatatcaga
    22201 ttatctatgc tcctgatgtt ttagagaagc taaaagaaat tcgtgattat atttctcaaa
    22261 actattcctc aacatcaggt cagcgtaaaa tggagcaaat cattagcgac atagaaaaac
    22321 tcgaggtttt cccagaagtt ggttttgatg ctgatgaaaa atatggttca aaaatcagcc
    22381 attatcacag cactaaaggt tacaccttaa gtaaagatta tattgtccta taccatatcg
    22441 agggggaaga aaatagggtc gttattgatt acttgcttcc tactcgaagc gactatataa
    22501 agttattcaa ataacacgtt aaaagcctta gcagtcttgc tagggctttt ttggtagatt
    22561 acaaattaac taggagcaaa atgagttcgg gctgtttagt agatattcca caaagaagcc
    22621 aaagactacg aagctaggct aatctacctt aaggcttcag gaaacttgga ggagttcacc
    22681 aagccaactc ataaaactta tagcgagata ttcgagaaat ggtatcaagc ctatcatgat
    22741 acggtagagc caaccacggc ttctcgtact cttgatctgt ttcgacttca cattttgcca
    22801 gtcatgggag aattgcccat taacaaaacc tcccc
//
