LOCUS       NZ_CAAHMR010000001     23767 bp    DNA     linear   CON 11-MAY-2024
DEFINITION  Streptococcus pyogenes strain Bra016, whole genome shotgun sequence.
ACCESSION   NZ_CAAHMR010000001
VERSION     NZ_CAAHMR010000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (03-APR-2019) WTSI, Pathogen Informatics, Wellcome Trust
            Sanger Institute, CB10 1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900984225.1-RS_2024_05_11
            Annotation Date                   :: 05/11/2024 02:59:40
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,760
            CDSs (total)                      :: 1,704
            Genes (coding)                    :: 1,661
            CDSs (with protein)               :: 1,661
            Genes (RNA)                       :: 56
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 47
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 43
            CDSs (without protein)            :: 43
            Pseudo Genes (ambiguous residues) :: 0 of 43
            Pseudo Genes (frameshifted)       :: 22 of 43
            Pseudo Genes (incomplete)         :: 20 of 43
            Pseudo Genes (internal stop)      :: 16 of 43
            Pseudo Genes (multiple problems)  :: 13 of 43
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:18:04
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 474997
            Orig. end                         :: 498764
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CAAHMR010000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23767
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="2"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..23767
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23767
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13767](-)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13767)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     misc_feature    complement(132..143)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.03"
                     /tool="antismash"
     misc_feature    155..169
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.38"
                     /tool="antismash"
     gene            complement(1396..1896)
                     /locus_tag="E9727_RS02415"
     CDS             complement(1396..1896)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985256.1"
                     /locus_tag="E9727_RS02415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="QueT transporter family protein"
                     /protein_id="WP_002985256.1"
                     /transl_table=11
                     /translation="MTKLTVHDYVHIGLVAALYVVLTITPPLNAISYGMYQFRISEMMN
                     FLAFYHRKYIIAVTLGCMIANFYSFGLIDVFVGGGSTLIFVTLGVILFSKYQKDYLFNG
                     IFNKAFVYFSFFFATSMFTVAIELYFFGAPFLLTWFTTALGELVSLLIGSLIIDKLSQR
                     ISF"
     regulatory      complement(1894..2009)
                     /bound_moiety="preQ1"
                     /db_xref="RFAM:RF01054"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF01054"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="PreQ1 riboswitch class II; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            complement(2174..4906)
                     /locus_tag="E9727_RS02420"
                     /old_locus_tag="SAMEA3919085_00494"
     CDS             complement(2174..4906)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985259.1"
                     /locus_tag="E9727_RS02420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_00494"
                     /product="SpnA family nuclease"
                     /protein_id="WP_115368139.1"
                     /transl_table=11
                     /translation="MINKKYIIPVSLLTLAITLTSVEEVTSRQNLTYANEIVTQRPKRE
                     SVISDKSNFPVISPYLASVDFGERKTPLPTPDKGVKVTTEQSIAQVRKGPEERTYTVTG
                     KITSVINGWGGYGFYIQDSEGIGLYVYPQKDLGYSKGDIVQLTGTLTRFKGDLQLQQVT
                     AHKKLELSFPTSVKEAVISELETTTPSTLVKLSHVTVGELSTDQYNNTSFLVRDDSGKS
                     IVVHIDHRTGVKGADVVTKISQGDLINLTAILSIVDGQLQLRPFSLEQLEVVKKVTSSN
                     SDASSRNIVKIGEIQGASHTSPLLKKAVTVEQVVVTYLDDSTHFYVQDLNGDGDLATSD
                     GIRVFAKNAKVQVGDVLTISGEVEEFFGRGYEERKQTDLTITQIVAKAVTKTGTAQVPS
                     PLVLGKDRIAPANIIDNDGLRVFDPEEDAIDYWESMEGMLVAVDDAKILGPMKNKEIYV
                     LSGSSTRPLNNSGGVLLPANSYNTDVIPVLFKKGKQIIKAGDSYKGRLAGPVSYSYGNY
                     KVFVDDSKNMPSLMDGHLKPEKTNLQKDLSKLSIASYNIENFSANPSSTKDEKVKRIAE
                     SFIHDLNAPDIIGLIEVQDNNGPTDDGTTDATQSAQRLIDAIKKLGGPTYRYVDIAPEN
                     NVDGGQPGGNIRTGFLYQPERVSLSDKPKGGARDALTWVNGELNLSVGRIDPTNAAWKD
                     VRKSLAAEFIFQGRKVVVVANHLNSKRGDNALYGRVQPVTFKSEQRRHVLANMLAQFAK
                     EGTKHQANIVMLGDFNDFEFTKTIQLIEEGDMVNLVSRHDISDRYSYFHQGNNQTLDNI
                     LVSRHLLDHYEFDMVHVNSPFMEAHGRASDHDPLLLQLSFSKENDKAESSKQSVKAKKT
                     SKGKLLPKTGDSLVYVITLLGTASLLVPILLLIKGKKES"
     misc_feature    5108..5123
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.72"
                     /tool="antismash"
     misc_feature    5229..5240
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 18.98"
                     /tool="antismash"
     misc_feature    5458..5471
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 24.45"
                     /tool="antismash"
     gene            complement(5478..6596)
                     /locus_tag="E9727_RS02430"
                     /old_locus_tag="SAMEA3919085_00495"
     CDS             complement(5478..6596)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985264.1"
                     /locus_tag="E9727_RS02430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_00495"
                     /product="ABC transporter permease"
                     /protein_id="WP_030126746.1"
                     /transl_table=11
                     /translation="MICFIKTLFVKIKRKKTSYVTFFLMPILTTLLALSLSFSNNNQAK
                     IGILDKDNSQISKQFIAQLKQNKKYDIFTKIKKEHIDHYLQDKSLEAVLTIDKGFSDKV
                     LQGKSQKLNIRSIANSEITEWVKAQTNYLLENYNIIGDVALGNEDTFNRILQKNQQLNY
                     DVKQVTLTDRSRSKAVSSTTTGFLLILMLGSTSVIYSGILADKSSQLYHRLMLSNLSRF
                     RYMLSYVCVGFVAFTIQIVIMLSLLKVFNISFFVPTSLLLIIFFLFSLLAIGFGLLIGA
                     ITQNSQQSSQLANLIVMPTSMLAGCLWPLSITPSYMQAIGKLLPQNWVLSAIAIFQSGG
                     TLSQAWSYLLALMGTALALIIFSSLLLKPTRL"
     gene            complement(6593..7720)
                     /locus_tag="E9727_RS02435"
                     /old_locus_tag="SAMEA3919085_00496"
     CDS             complement(6593..7720)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985266.1"
                     /locus_tag="E9727_RS02435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_00496"
                     /product="SagG family ABC transporter permease subunit"
                     /protein_id="WP_136022216.1"
                     /transl_table=11
                     /translation="MVLFHLIKKESLQIFRNRTALLMMVIFPILMIVILSFAFKSSFNT
                     ATTVPKLTIRYQLEGEKTDYQKNFLAFLKVLNQKLHLEAKPSNSLEKDRQRVSEGALTA
                     VLEVKKNQTIKVITNNINQQNADLINMLVKNYVDNAKTYDSIAALYPQQLNHIRKRSVD
                     YVKVSSIQTSKGMTSADYYAISMFTMITFYSMMSAMNLVLSDRQQRITNRIRLTGVSPS
                     LLVFGKLIGAMLATTVQLSLLYIFTRFVLRVNWGTNEWMLTGITASLVYLSVAIGIGLG
                     ISIKNEAFLTVASNTIIPIFAFLGGSYVPLTTLHSSIINQLSNISPIKWVNDSLFYLIF
                     GGQYNPIPVTLIVNISIGTIFIILALIGMRKQVTT"
     gene            complement(7729..8652)
                     /locus_tag="E9727_RS02440"
                     /old_locus_tag="SAMEA3919085_00497"
     CDS             complement(7729..8652)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017604.1"
                     /locus_tag="E9727_RS02440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_00497"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_002990429.1"
                     /transl_table=11
                     /translation="MSFVQLTNVVKSYKNGKKAVNDVSLSIEAGNIYGLLGPNGAGKST
                     LINLILGLIPLSSGKITVLGQSQKTIRKISSQIGYVPQDIAVYPDLTAYENVELFGSLY
                     GLKGAQLKKQVLKSLEFVGLHSQAKQFPSQFSGGMKRRLNIACALVHSPKLIIFDEPTV
                     GIDPQSRNHILESIRLLNKEGATVIYTTHYMEEVEALCDYIFIMDHGQVIEEGPKFELE
                     KRYVANLANQIIVTLTDSRHLELADKPDWSLIEDGEKLMLKIDNSDMTSVVHQLTQANI
                     TFSEIRHNHLNLEEIFLHLTGKKLRD"
     gene            complement(8675..9358)
                     /locus_tag="E9727_RS02445"
                     /old_locus_tag="SAMEA3919085_00498"
     CDS             complement(8675..9358)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985270.1"
                     /locus_tag="E9727_RS02445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_00498"
                     /product="SagF family protein"
                     /protein_id="WP_002985270.1"
                     /transl_table=11
                     /translation="MMLLVLLSFLGLTTLWLTSYRRRCLARWHLQWLMALSYQDFLDVL
                     LSLFQFVVIILVLFFYSATINLGEVLTFLTQTSWHWQILCYLVLYLMAIIEMTLLVLIL
                     IFDVLLQKDSRLLFKKITWLPFRQDKPVLSILLLGIVILVDSLFYLGLLILLGEQSLTS
                     LATLILGYGIVKACRYSGWLNVLLAFCLFTIVGLWAVTATLLYGWLVGAMILTVTYLMI
                     SCKEY"
     gene            complement(9355..10026)
                     /locus_tag="E9727_RS02450"
                     /old_locus_tag="SAMEA3919085_00499"
     CDS             complement(9355..10026)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017602.1"
                     /locus_tag="E9727_RS02450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_00499"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_011054325.1"
                     /sec_met_domain="Abi (E-value: 5.6e-11, bitscore: 38.3,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLSIQCLNLCFLLVTFCPSIPMQAIFGKEDSGYAFNLIGFLRAT
                     LIYDILALVSIYVLSPQITLSLESIDSKTFFMGLVFCVLIVLIELIFLHGLRCWQKKQW
                     LPATFSFVGTTNDWSKIGYPLLLALFEETIYRFLWFNILAFQWHLPTIIVLIVTSFCYA
                     LNHLLMGKSIFYAKLVTGIIYGSIYMLTSQLWLVVIMHVGGNLLVECLSHLQTKKKKEV
                     T"
     gene            complement(10001..11359)
                     /locus_tag="E9727_RS02455"
                     /old_locus_tag="SAMEA3919085_00500"
     CDS             complement(10001..11359)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407460.1"
                     /locus_tag="E9727_RS02455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_00500"
                     /product="YcaO-like family protein"
                     /protein_id="WP_134984535.1"
                     /sec_met_domain="YcaO (E-value: 1.8e-62, bitscore: 207.5,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 1.1e-110, bitscore:
                     365.5, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLYYYPSFNHIFDELKSLSGNRTGILNQSQVPVCNHPHDVYLKSI
                     TGQMPDYHKQFIGELSQVSYHIIGYGSYYEEALIKYLGESIERYATVIAGDLLSDRIVY
                     ASYNELKLLHKVMPLKYLQVFTQEQIALSCDLQMMMCDKMVTENDVLGWVKCPMFFEDA
                     EMYVPAQMLCVGYKTNETVGERRIIPGFSTGTASHKTLEAAMCNSLIEHIQIDSMMLSW
                     YTKKPCPKIIVDDPDIEVILEEARLGKDSLYDIIPIDMTVGEDNPLYTFGIILKNKYDE
                     GPYLLFGVQAGLDPKHALLRGIMEASAISYSYYYNLLYQKASLANIECEEPLFLDLDSN
                     VFYYAHPKDQDHKWKAFEPLISGEVLLSDLEDHSGKDKKEDLKTLLAYAKKVSPNAVFL
                     DITPPEALEKGWYVTRVLMPELLEMCIPAFPFANHPRMRQFGGVTNAFVHPMP"
     gene            complement(11379..12437)
                     /locus_tag="E9727_RS02460"
                     /old_locus_tag="SAMEA3919085_00501"
     CDS             complement(11379..12437)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03603"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cytolysin_C_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985275.1"
                     /locus_tag="E9727_RS02460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_00501"
                     /product="streptolysin associated protein SagC"
                     /protein_id="WP_002985275.1"
                     /sec_met_domain="Cytolysin_C_RRE (E-value: 6.6e-41,
                     bitscore: 134.1, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03603 (E-value: 1.2e-140, bitscore:
                     464.2, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYQLNSNVRVVTFQDTFCFRKGIWDFNEAILDLTQEPQNLKIVY
                     QEIVSQLVKGVAIDTETYENTLEPETFANLMEVISGLYYNDMLMLEDDYNLEENVMKIL
                     MGNFRFMAQAGHMVSNDPVLFISDSTYVNESAELLAEQLHLQLQVASDDLKMLIQQTDV
                     SSRLDALEHRRNMNCLSDALCDYQSIIICQERLNIMMLRHLNEVSVAMKKQLVIGFVDG
                     PFLHACTLNPPHSADFDSLERRVLARLQDSTLYQHFANQILPATQDVSQAYLPLLNVLM
                     NLVVSEAFIIAQTGSSKFEGRLLSIYLPTLEIQVQDILKMSNSQTQGALAKLKYEDQQI
                     STREIVKKLLDE"
     aSDomain        complement(12168..12437)
                     /aSDomain="Cytolysin_C_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing discrete C protein in a
                     SLS/cytolysin LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_E9727_RS02460_Cytolysin_C_RRE.1"
                     /evalue="2.40E-42"
                     /identifier="RREFam014.1"
                     /label="E9727_RS02460"
                     /locus_tag="E9727_RS02460"
                     /protein_end="90"
                     /protein_start="0"
                     /score="134.1"
                     /tool="antismash"
                     /translation="MKYQLNSNVRVVTFQDTFCFRKGIWDFNEAILDLTQEPQNLKIVY
                     QEIVSQLVKGVAIDTETYENTLEPETFANLMEVISGLYYNDMLML"
     gene            complement(12434..13384)
                     /gene="sagB"
                     /locus_tag="E9727_RS02465"
                     /old_locus_tag="SAMEA3919085_00502"
     CDS             complement(12434..13384)
                     /codon_start=1
                     /gene="sagB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922108.1"
                     /locus_tag="E9727_RS02465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_00502"
                     /product="streptolysin S biosynthesis dehydrogenase SagB"
                     /protein_id="WP_011054324.1"
                     /sec_met_domain="PF00881 (E-value: 2.3e-32, bitscore:
                     108.0, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFFTKEKQPKENCPPITVEKARQLFEFNTNHLSLSDYHHQTVLK
                     TSKQLVAQHLMPNATDNLSQHFLMNYKANNNYLGFQASIVDFFTDSAVANFSSSYVYES
                     QEKIIRLPKPTKISTALSTCIIKRRSHRQFSDRQMPLQDLSNILYYACGVSSQASIRDG
                     ASDKITLRNCASGGGLYPIHLVFYARNISKLIDGFYEYLPYQHALRCYRHSSEENVRDF
                     AEYGAINAENCNIIIIYVYHYIKNTRKYGNQATAYAFIESGEIAQNIQLTATALTYGSI
                     DIGGYNKEYLQELLDLDGLGEHVIHMTLVGTKESQ"
     misc_feature    13582..13599
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 22.53"
                     /tool="antismash"
     gene            complement(13606..13767)
                     /gene="sagA"
                     /locus_tag="E9727_RS02470"
                     /old_locus_tag="SAMEA3919085_00503"
     CDS             complement(13606..13767)
                     /codon_start=1
                     /gene="sagA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03602"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985285.1"
                     /locus_tag="E9727_RS02470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_00503"
                     /product="TOMM family cytolysin streptolysin S"
                     /protein_id="WP_002985285.1"
                     /sec_met_domain="TIGR03602 (E-value: 7.7e-30, bitscore:
                     98.4, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKFTSNILATSVAETTQVAPGGCCCCCTTCCFSIATGSGNSQGG
                     SGSYTPGK"
     gene            complement(14442..15749)
                     /gene="eno"
                     /locus_tag="E9727_RS02475"
                     /old_locus_tag="SAMEA3919085_00504"
     CDS             complement(14442..15749)
                     /EC_number="4.2.1.11"
                     /codon_start=1
                     /gene="eno"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985288.1"
                     /locus_tag="E9727_RS02475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_00504"
                     /product="surface-displayed alpha-enolase"
                     /protein_id="WP_002985288.1"
                     /transl_table=11
                     /translation="MSIITDVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGASTGE
                     HEAVELRDGDKSRYLGLGTQKAVDNVNNIIAEAIIGYDVRDQQAIDRAMIALDGTPNKG
                     KLGANAILGVSIAVARAAADYLEVPLYTYLGGFNTKVLPTPMMNIINGGSHSDAPIAFQ
                     EFMIMPVGAPTFKEGLRWGAEVFHALKKILKERGLVTAVGDEGGFAPKFEGTEDGVETI
                     LKAIEAAGYEAGENGIMIGFDCASSEFYDKERKVYDYTKFEGEGAAVRTSAEQVDYLEE
                     LVNKYPIITIEDGMDENDWDGWKVLTERLGKRVQLVGDDFFVTNTEYLARGIKENAANS
                     ILIKVNQIGTLTETFEAIEMAKEAGYTAVVSHRSGETEDSTIADIAVATNAGQIKTGSL
                     SRTDRIAKYNQLLRIEDQLGEVAQYKGIKSFYNLKK"
     gene            15976..16434
                     /locus_tag="E9727_RS02480"
                     /old_locus_tag="SAMEA3919085_00505"
     CDS             15976..16434
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990451.1"
                     /locus_tag="E9727_RS02480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_00505"
                     /product="YueI family protein"
                     /protein_id="WP_020905037.1"
                     /transl_table=11
                     /translation="MTNLEDKLLKGAWGERRLNPEQQRYYLGTYAERVVLSALLDEAQT
                     KTVKDYLKRELPSLQLVYQPLHLKISSKLAPQLQILYMKLAKENYLPVTIITETHMTSP
                     FAFILHTDHAINLKETRLEVILKQTKNDQLSKQTPEKTKSFWKRFLKK"
     gene            complement(16566..18290)
                     /gene="ezrA"
                     /locus_tag="E9727_RS02485"
                     /old_locus_tag="SAMEA3919085_00506"
     CDS             complement(16566..18290)
                     /codon_start=1
                     /gene="ezrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407454.1"
                     /locus_tag="E9727_RS02485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_00506"
                     /product="septation ring formation regulator EzrA"
                     /protein_id="WP_020905036.1"
                     /transl_table=11
                     /translation="MSSGIILLIVAIVLLVIIAYLVGVIIRKRNDSLITSLEERKQALF
                     ALPVNDEIEEVKSLHLIGQSQTSFREWNQKWVDLTVNSFADIENHIFEAENLNDTFNFI
                     RAKHEINSVESQLNLVEEDIASIREALNILKEQEEKNSARVTHALDLYEKLQASISENE
                     DNFGSTMPEIDKQMKNIETEFSQFVALNSSGDPVEASEVLDRAEEHTIALGQITEQIPA
                     IVAKLEDDFPDQLDDLETGYRRLLEENYHFPEKNIEARFQEIRESIRANSSELVTLDLD
                     RAREENAHIQERIDSLYEVFEREIAAYKVAAKNSKMLPRYLAHVKRNNEQLKDEIARLS
                     RKYILSETESLTVKAFEKDIKEIEDSTLAVAEQFGLQEKPFSELQVTFERSIKTLTNVE
                     SGQMDVFAAVKDIEKIESQARHNLDVYVTQLHMIKRYMEKRHLPGIPQDFLSAFFTTSS
                     QLEALMDELSRGRINIEAVSRLSEVATVAIANLEDLTYQVVQNATLTEQLLQYSNRYRS
                     FEAGVQSSFEHALRLFEVENDYQASFDEISYALETVEPGVTDRFVNSYEKTREHIRF"
     misc_feature    complement(18510..18528)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 22.68"
                     /tool="antismash"
     gene            complement(18658..20610)
                     /gene="gyrB"
                     /locus_tag="E9727_RS02490"
                     /old_locus_tag="SAMEA3919085_00507"
     CDS             complement(18658..20610)
                     /EC_number="5.6.2.2"
                     /GO_component="GO:0009330 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) complex [Evidence
                     IEA]"
                     /GO_function="GO:0003918 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) activity [Evidence
                     IEA]"
                     /GO_process="GO:0006265 - DNA topological change [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="gyrB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002283665.1"
                     /locus_tag="E9727_RS02490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_00507"
                     /product="DNA topoisomerase (ATP-hydrolyzing) subunit B"
                     /protein_id="WP_011017600.1"
                     /transl_table=11
                     /translation="MIEENKHFEKKMQEYDASQIQVLEGLEAVRMRPGMYIGSTAKEGL
                     HHLVWEIVDNSIDEALAGFASHIKVFIEADNSITVVDDGRGIPVDIQAKTGRPAVETVF
                     TVLHAGGKFGGGGYKVSGGLHGVGSSVVNALSTQLDVRVYKNGQIHYQEFKRGAVVADL
                     EIIGTTDVTGTTVHFTPDPEIFTETTQFDYSVLAKRIQELAFLNRGLKISITDKRSGME
                     QEEHFHYEGGIGSYVEFLNDKKDVIFETPIYTDGELEGIAVEVAMQYTTSYQETVMSFA
                     NNIHTHEGGTHEQGFRAALTRVINDYAKKNKILKENEDNLTGEDVREGLTAVISVKHPN
                     PQFEGQTKTKLGNSEVVKITNRLFSEAFQRFLLENPQVARKIVEKGILASKARIAAKRA
                     REVTRKKSGLEISNLPGKLADCSSNDANQNELFIVEGDSAGGSAKSGRNREFQAILPIR
                     GKILNVEKATMDKILANEEIRSLFTAMGTGFGADFDVSKARYQKLVIMTDADVDGAHIR
                     TLLLTLIYRFMRPVLEAGYVYIAQPPIYGVKVGSEIKEYIQPGIDQEDQLKTALEKYSI
                     GRSKPTVQRYKGLGEMDDHQLWETTMDPENRLMARVTVDDAAEADKVFDMLMGDRVEPR
                     RDFIEENAVYSTLDI"
     misc_feature    complement(20578..20591)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.9"
                     /tool="antismash"
     gene            complement(20611..21171)
                     /locus_tag="E9727_RS02495"
                     /old_locus_tag="SAMEA3919085_00508"
     CDS             complement(20611..21171)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990461.1"
                     /locus_tag="E9727_RS02495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_00508"
                     /product="HAD-IA family hydrolase"
                     /protein_id="WP_023612339.1"
                     /sec_met_domain="HAD_2 (E-value: 4.6e-17, bitscore: 58.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNYQDYIWDLGGTLLDNYELSTQAFVQTLAFFSLPGDHDAVYQKL
                     KESTAIAVATFAPNEPEFLHVYRLREADKLAQPIWCLGAKEILEKIATSGSRNFLISHR
                     DCQVNQLLEQAGLLIYFTEVVTASNGFARKPNPESLFYLKEKYDINSGLVIGDRLIDKQ
                     AGQAAGFNTLLVDGRKNLLEIVT"
     gene            complement(21274..>21565)
                     /locus_tag="E9727_RS09170"
                     /pseudo=""
     CDS             complement(21274..>21565)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003056811.1"
                     /locus_tag="E9727_RS09170"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="rod shape-determining protein RodA"
                     /pseudo=""
                     /transl_table=11
                     /translation="LLALCL"
     gene            21618..21833
                     /locus_tag="E9727_RS02500"
     CDS             21618..21833
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012798.4"
                     /locus_tag="E9727_RS02500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="WP_020905033.1"
                     /transl_table=11
                     /translation="MKIYGDYHTHLFRHSHISLLAEKGLPPKVVRDRFSHSDPNLRLSI
                     YSHTSVNREELVNNRTASFVLLTLIE"
     tRNA            complement(21877..21948)
                     /anticodon=(pos:complement(496910..496912),aa:Arg,seq:cct)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="E9727_RS02505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="SAMEA3919085_00509"
                     /product="tRNA-Arg"
     gene            complement(21877..21948)
                     /locus_tag="E9727_RS02505"
                     /old_locus_tag="SAMEA3919085_00509"
     gene            complement(22195..22542)
                     /gene="rplS"
                     /locus_tag="E9727_RS02510"
                     /old_locus_tag="SAMEA3919085_00510"
     CDS             complement(22195..22542)
                     /GO_component="GO:0000311 - plastid large ribosomal subunit
                     [Evidence IEA]"
                     /GO_component="GO:0022625 - cytosolic large ribosomal
                     subunit [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rplS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005590628.1"
                     /locus_tag="E9727_RS02510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919085_00510"
                     /product="50S ribosomal protein L19"
                     /protein_id="WP_002985298.1"
                     /transl_table=11
                     /translation="MNPLIQSLTEGQLRSDIPNFRPGDTVRVHAKVVEGTRERIQIFEG
                     VVISRKGQGISEMYTVRKISGGIGVERTFPIHTPRVDKIEVIRHGKVRRAKLYYLRALQ
                     GKAARIKEIRR"
ORIGIN
        1 tcactaccac aagatgggca tagtttagga ataagcatga cttcttgctg gttccgctta
       61 ctcataacga catttaagac agcaggaata atgtcccctg ccttatatac aatcactgta
      121 tcaccaatac ggatatcttt ttcggcaata taatccacat tatgtagggt tgcacgactc
      181 acggttgtcc ccgctagttg cacaggagtt agattcgctg taggtgtgac cacgcctgtt
      241 cgtcccactg tccagtcaac cgaaaggatt tctgcctctt tttcttctgc tggaaatttg
      301 taagcaatgg cccagcgtgg agctttaacc gtaaacccta gctcttcttg catggctagg
      361 ctattaactt taataacaac gccatctatg tcataagcta attgatctct ttttgcctca
      421 atagttttga taaaatccca aatctcatcc atagacgatg tgagttgata atacggattt
      481 actgaaaaac ctagatctgc taattctgct aagacctcat tttgttgatt tctagctgtc
      541 ggactagctt cttgatacaa aaaagtggct agttgacgtt tagcaaccac tgacgtatct
      601 agctgcctta gtgtcccagc ggcagcattt ctaggattag caaattcagt ctccccattt
      661 tcttggcgtg cttcattgat cgctttaaag gactgacgag acatgtaagc ctctcctcga
      721 acggtgatgg ttaaaggctc actcaattgg tgaggaatat cctttatttt tttgatattt
      781 tctgtgatat tttcaccgat attgccatca ccccgtgttg ctccaacctg taagaagcca
      841 ttctcataac tcaaggaaat agataaacca tcaattttta actctgctag ataggtggca
      901 tttggaaatt cggctttgac gcgcttatca aaagcatcca gctcctcacg tgaaaaagca
      961 tcctgcaaac taaaaagcgg atactgatgt cgatattttt caaacccctt taaaatagtc
     1021 cctccaacct gctgcgttgg gctatcttgc aagacatact cgggatatga ctgctctaaa
     1081 gtcaccagtt cacgataaag cttatcatag tcactgtcag aaactgatgg ggcatcttta
     1141 gtataatagt cataacggta acggttaaga agatctgtta attcttttat gcgttttttc
     1201 atacttttat tttatcataa aagataacaa atgagctatt tctatatcat aacaacatca
     1261 aaagtaatcg ttggccactc catatggtac tattagctaa agtgttaaat atttctatct
     1321 agaacgattt taacattaca aacaacataa aaaagagaag ggtattgacc caactctttt
     1381 gagtatgatg cattactaaa aggaaattct ttgagacaac ttatcaataa taagtgatcc
     1441 tatgagcaga gatactaatt ctcctaacgc agttgtaaac catgttaata aaaatggagc
     1501 tccaaagaag taaagttcga ttgctacagt aaacatggaa gttgcaaaaa agaaagaaaa
     1561 gtaaacaaaa gctttattaa aaataccatt aaaaagataa tctttttgat acttactaaa
     1621 caaaatcaca cctaaggtca caaaaataag agttgaaccg ccgcctacaa agacatcaat
     1681 cagtccgaaa ctataaaagt tagcaatcat acatccaaga gtcaccgcaa taatatactt
     1741 gcgatgataa aaagctaaga aattcatcat ttcagatatt ctaaattgat acatcccata
     1801 agaaatcgca tttaaaggtg gggtaatagt taagacaaca tacaaggcag ctactagccc
     1861 aatgtgaaca tagtcgtgta cagtcaattt tgtcattttt tctcctttaa cgtctggata
     1921 actctcaaaa gctatctacg tttctaatat gcttggtgaa agggaactaa gcaccaaggg
     1981 ttgcaaagca acggttacat tgtaccataa aacaattagc ttgacaaaag tctttagcaa
     2041 gtaaagctgt cttattgtta tcttcttttg ttatcaatct tagtttttat atagtcatcc
     2101 attttagctt aaggtctaac gtaagtatat caagccttta acgactcttt atgaactgca
     2161 attcttcaaa tcgctatgat tcctttttgc ctttaatcaa taataaaata ggcactaata
     2221 aactagccgt tcctagtagc gttatcacat aaacaagact atctcctgtt tttggcaaca
     2281 gttttccttt tgaagttttt ttagctttta cactttgttt agaagactct gccttatcat
     2341 tttctttaga aaatgataat tgaagtaaca atggatcatg atctgatgcg cgtccgtgag
     2401 cttccataaa tggggaattc acatgaacca tgtcaaattc gtagtgatca agtaaatggc
     2461 gtgaaactaa tatattatca agggtctgat tattgccttg gtgaaaataa gaataccgat
     2521 ctgaaatatc atgtcggctc accaagttaa ccatatcacc ttcttcgatt aattgaatcg
     2581 tctttgtgaa ttcaaaatca ttaaagtcac ctagcatcac aatattagct tggtgctttg
     2641 tcccttcttt cgcaaattgt gctagcatat tagccaagac gtgacgtctt tgctcagatt
     2701 taaaagtgac tggttgcaca cgaccataaa gagcattatc cccacgctta gagttcaaat
     2761 gatttgcaac aacaacgact ttacgacctt ggaagataaa ttctgctgct agtgatttac
     2821 gaacatcttt ccaagcggcg ttagttggat caattcgacc aacactaagg tttaattctc
     2881 cattaaccca agttagagca tcacgagcac cgccttttgg cttatcagaa aggctgacgc
     2941 gctctggttg ataaaggaat cctgttcgaa tattaccacc tggttgacct ccgtcaacat
     3001 tattttctgg agcaatatca acataacgat aagttgggcc acctagtttt ttaatagcat
     3061 caatgagacg ttgcgcgctt tgtgtcgcat ccgttgtccc atcatcagtc ggcccattat
     3121 tatcttggac ttcaattaat ccaataatgt ctggagcatt cagatcatga ataaaggatt
     3181 cggcaatccg tttgaccttc tcatctttag ttgaagaagg attggctgag aagttttcaa
     3241 tattgtaaga agcaatgctt aacttgctaa ggtctttttg caagtttgtt ttttcaggtt
     3301 ttagatgacc atccattaaa cttggcatgt ttttgctgtc atcaacaaag accttgtaat
     3361 taccatagct ataagatact ggcccagcta atcttccttt gtaagagtct cctgctttaa
     3421 taatttgttt accttttttg aaaagaacag gaatcacatc tgtgttataa gaattagctg
     3481 gaagtaatac tccacctgaa ttatttaacg gtcttgtact agagccagat aagacataaa
     3541 tttctttatt tttcattgga ccaaggattt tagcatcatc aaccgccact aacatgcctt
     3601 ccattgattc ccaataatca atagcgtctt cttctggatc aaacacacgc aagccatcat
     3661 tatcaataat attggctggc gcgatacgat ctttccctaa aacaagcggt gatggaactt
     3721 gagctgtccc tgttttggtc actgctttag ccacaatttg ggtgatggta aggtcagtct
     3781 gcttacgttc ctcataacca cgaccaaaga attcttccac ttcacctgaa atggtcaaaa
     3841 catcgccgac ttgaacctta gcgtttttag caaaaacacg aataccatct gaagtcgcta
     3901 aatcaccatc accattaaga tcttgaacat aaaaatgagt ggaatcgtct aaataagtga
     3961 caacaacctg ttctacggtg accgcttttt tgagaagtgg cgacgtatga ctagctcctt
     4021 gaatctcgcc tattttcaca atattacgag atgaagcatc actatttgag cttgtgacct
     4081 ttttaaccac ttccaattgt tcaagagaaa acggtcttaa ttgtaactga ccatcaacaa
     4141 tagacaatat ggctgtgagg ttaatcaaat caccctgact tattttagta acaacatcag
     4201 cccctttaac ccctgtacga tgatctatat gaacaactat acttttacca ctatcatccc
     4261 ttacaaggaa agatgtgttg ttatattgat cagttgataa ttctccaact gtcacgtgag
     4321 ataacttaac taatgttgag ggtgttgttg tttctaattc tgatattact gcttctttaa
     4381 cagaagtcgg aaaagataac tctaactttt tgtgtgcagt cacctgttgg agttgtaaat
     4441 cacctttaaa gcgagtaagt gtacctgtta attgaacaat atctccctta ctgtatccta
     4501 aatctttttg aggataaaca taaagtccaa taccttcact atcttgaata taaaagccat
     4561 agcctcccca gccattgatc acactcgtaa tcttgccagt aacagtatag gttctttctt
     4621 caggcccctt tcttacttga gcaatagact gttcagtagt tacttttact cctttatcag
     4681 gtgttggcaa aggtgttttt ctctcaccaa aatccacact tgctaggtaa ggtgatatga
     4741 cgggaaaatt cgatttatca ctaataacag attctctctt tggcctttgt gttacgattt
     4801 cattggcata agtcaaattt tgacgtgaag taacttcttc aacactagta agcgtaatag
     4861 ctagtgtcaa caatgaaaca ggtattatat atttcttgtt aatcatgata tctcctttta
     4921 atgtgattag tttaagacaa caacaagatt ttatttttga atattaacct ccacctgaga
     4981 ctatgaattg ggatacactt tctgtttgca ttaattatac tatcaagtaa cacgattaga
     5041 tcttttcttt taatctgtta agtcacccaa ttaaagactt gtttgatctg acataacatc
     5101 acaagcgccc ctgatagcga acaagacagc tttatagcat tcgatacatg cttattgtaa
     5161 caaaaacatt tcataaaata aatacgtttt tacacctttt tttaataaca ttagttttta
     5221 tgtttattga aaacgttttt ttaaaatact ttgacaactc atttatcaac aaaaacgaac
     5281 tttctagaga ggtcgctttt gataatatgc tctctaaaaa acacagtaac aacagtaaca
     5341 tcgcaatcgc ttttaacaaa agataagtgc actagagaaa atataagcaa aaagcaaccc
     5401 ttttattgca tataagccaa taaaagggct acctggtagt tagctaatta ggaaagtatt
     5461 ttttaacaaa agactaatta tagtctggta ggttttaata ataaacttga aaaaataatc
     5521 aaagctagtg ctgttcccat tagagctaac aagtatgacc aagcctgaga taaggtccct
     5581 ccactttgaa aaatagctat ggctgataaa acccaatttt gtggtaataa cttaccaatt
     5641 gcttgcatgt aagaaggcgt aatagacaat ggccataaac agccagccaa cattgaagtc
     5701 ggcattacaa taagattagc taactggcta ctttgttggg aattttgtgt gatagctcca
     5761 atcagcaggc caaagcctat cgctaataaa ctaaaaagga aaaaaataat caaaagaagt
     5821 gatgtcggaa caaaaaaact aatattaaat acttttaaca aactcagcat aatgacaatt
     5881 tgaatcgtaa aagcaacaaa tcctacacag acgtaactca acatatagcg aaaacgagat
     5941 aagttcgata acattaatcg atggtataac tgactagatt tatctgccaa aataccactg
     6001 taaatcacgc tcgtactacc taacattaga ataagcaaaa atcctgtcgt tgtggaagat
     6061 actgctttgc tacgtgatcg gtctgtcaaa gttacttgct taacatcata atttaactgt
     6121 tggttttttt ggagaattct attaaaagta tcttcgttac ctagagccac atcccctata
     6181 atattatagt tttccaatag ataattggtc tgtgctttta cccactctgt aatttcgcta
     6241 ttagcaatcg aacgtatatt gagtttttga gattttcctt gcaacacttt atctgagaac
     6301 cctttatcaa tagtcaatac cgcttctaga gatttatctt gaaggtagtg atcaatatgc
     6361 tcttttttga ttttggtaaa aatgtcgtac tttttgtttt gctttagttg agcaataaat
     6421 tgtttagata tctgactatt atctttatct aatatcccaa ttttagcctg attattattt
     6481 gaaaaactca aagataaagc caaaagtgtc gttaaaatag gcattaaaaa gaatgtcaca
     6541 taacttgttt ttttgcgctt tatcttaaca aatagagttt ttataaaaca aatcatgtcg
     6601 tcacctgctt tctcatacct attaatgcca atattataaa aattgttccg atactaatat
     6661 taacgatcaa agttacagga atcggattat attgaccacc aaaaataaga tagaacaaac
     6721 tatcattaac ccatttaata ggagatatat tcgacaattg attaataata gagctgtgta
     6781 atgttgtcaa cggaacgtaa ctgcctccta aaaaggcgaa tataggaata atagtattgg
     6841 atgcaaccgt taaaaaagcc tcatttttaa tgcttatgcc tagcccgata cctatagcta
     6901 cagagagata gactaaggag gctgttatac cagtaagcat ccactcatta gtgccccaat
     6961 taactcgtaa aacaaacctt gtaaaaatgt ataaaagact caattgaaca gttgttgcta
     7021 acatagcacc tattaatttc ccaaagacta aaagacttgg agaaactcct gttaagcgaa
     7081 tacgatttgt aatccgttgt tgacgatctg acaaaacaag gttcatcgca gacatcatac
     7141 tataaaaagt aatcatggta aacatggaaa tagcataata atcagctgat gtcattcctt
     7201 tacttgtctg tattgaactg accttaacat agtccacact tcgctttctg atatgattta
     7261 attgttgagg ataaagagct gctatcgagt cataagtttt agcattatct acataatttt
     7321 ttactagcat attgattaaa tctgcatttt gctgattaat attattagta ataaccttaa
     7381 tggtctgatt cttcttcact tctaaaacag ccgttaaggc tccttcactg accctttgtc
     7441 gatctttttc aagagaatta ctaggtttag cctctaaatg aagtttttgg tttaaaactt
     7501 ttaaaaaagc aagaaaattt ttctggtaat ccgttttttc accctctaat tggtaacgaa
     7561 tggtcaattt agggactgtt gtcgcagtat taaaacttga tttaaaggca aaacttaaaa
     7621 taacgatcat caaaattgga aaaatcacca tcatcaataa ggctgttcgg tttctaaaaa
     7681 tctgtaaact ttcttttttg attaaatgaa ataaaaccat agtaacctct aatctcgtaa
     7741 cttcttacct gttaagtgta agaaaatttc ttctaaattc aaatggttat gtctaatctc
     7801 gctaaaagta atattggcct gtgtgagctg atgaacaact gatgtcatat cactattatc
     7861 aatcttcaac atgagttttt ctccatcttc tatcaaagac caatcaggct tatctgccag
     7921 ttccaaatga cgtgaatctg ttagagttac aataatctgg tttgctagat ttgcaacgta
     7981 acgtttttcc agttcaaatt taggtccttc ttcaataact tgaccatgat ccataataaa
     8041 aatataatca caaagagcct ctacttcttc catataatgg gtcgtataaa taactgtggc
     8101 accttctttg tttagcaaac gaatcgactc taaaatatga ttacgtgatt gaggatcaat
     8161 ccctacagtc ggttcgtcaa aaatgattaa tttaggtgaa tgaactagcg cacaagcgat
     8221 atttaaccgt ctcttcattc ctcctgagaa ttgacttgga aactgcttag cttgggagtg
     8281 tagtcccaca aattctaaac tttttagaac ttgtttttta agctgagctc cctttaagcc
     8341 ataaagtgac ccaaatagtt ctacattttc ataagcagtt aggtctggat aaacagcaat
     8401 gtcttgagga acataaccta tctgcgaact tatttttcga atagtctttt gggattgccc
     8461 taaaacagta attttaccgg aactcaaagg gatcaagcct aagataagat taatcaaggt
     8521 agacttacca gcaccatttg gtcctaacaa accataaata ttacctgctt caatagacaa
     8581 ggaaacatca ttgacagctt tcttgccgtt tttgtaggac ttgacaacat ttgttaattg
     8641 tacaaaactc atatatcact cctttttaat attgctaata ctctttgcaa ctaatcatca
     8701 aataagtcac cgttaatatc atcgcaccta ctagccaacc atataataaa gttgccgtaa
     8761 ctgcccatag tccaactata gtgaaaagac aaaaagctaa tagtacattt aaccaacctg
     8821 aatagcgaca agccttgact atcccataac ctaaaataag cgttgctaaa cttgttagcg
     8881 actgttctcc taataatata agcaagccca aataaaagag actgtctact agaataacta
     8941 tgcctagcaa aagtatactt aagactggtt tatcttgtct aaaaggcagc caagttattt
     9001 ttttaaagag caatcgacta tctttctgga gcaaaacatc aaagataaga attaaaacta
     9061 aaagcgtcat ctctatgatg gccataagat acaacactaa ataacaaaga atctgccaat
     9121 gccagctagt ttgtgtcaaa aaggtcagaa cctctcctag attaatagta gctgagtaaa
     9181 agaacaaaac aagtataata acgacaaatt gaaacagact cagtaagaca tctaaaaaat
     9241 cttgatagga taaggccatt aaccattgaa gatgccatct agccaaacaa cgtcttcgat
     9301 aactggtcaa ccaaagagta gttagaccta aaaacgacag caaaaccaat agcatcatgt
     9361 cacctccttc ttcttttttg tttgaagatg gctaagacac tcaactagca agttacctcc
     9421 tacatgcatt atcacaacca accacaattg actagtcagc atgtaaatac taccataaat
     9481 gatgcctgtt accaacttag cataaaaaat ggatttcccc atcaataagt gatttaaagc
     9541 atagcaaaaa ctagttacaa ttaaaacaat aattgttggt aaatgccatt gaaaagctaa
     9601 tatattaaac cacaaaaaac gataaatcgt ctcttcaaat aaagctagta ataaaggata
     9661 gccaatctta gaccaatcat ttgtcgttcc tacaaacgag aaagttgcag gaagccattg
     9721 ctttttttgc caacaacgta aaccatgtaa gaaaatgagt tcaatcagta ctatcaagac
     9781 gcaaaataca agtcccataa agaacgtctt actatcaata ctttcaagag acaaggttat
     9841 ttgaggtgac aaaacataaa tacttaccaa agccaaaatg tcataaatca gagttgctct
     9901 tagaaaacca attaaattaa atgcataacc actatcttct tttccaaaaa tagcttgcat
     9961 aggaattgaa ggacaaaaag ttaccaacaa aaaacaaaga ttaaggcatt ggatggacaa
    10021 aggcatttgt tacacctcca aactgtctca ttcgtggatg attagcaaaa ggaaatgctg
    10081 gtatacacat ttcaagaagt tctggcatca gaactcgcgt gacgtaccag cctttttcta
    10141 gagcttcagg aggtgtaata tctaaaaaga cagcattagg actgactttc ttagcataag
    10201 ctaataaagt cttcaaatct tcttttttat ctttaccaga atgatcttcc aaatcactta
    10261 acagaacttc tcctgaaatc aaaggttcaa aggccttcca tttatggtct tggtccttgg
    10321 gatgtgcata atagaaaaca ttactatcta aatctaaaaa caaaggttct tcgcattcaa
    10381 tatttgcaag ggaagctttt tgatataaaa gattatagta gtaactatag ctaatagctg
    10441 aagcttccat gatccctctt agcaaagcat gtttaggatc taacccagcc tgcactccaa
    10501 acaagaggta aggcccttca tcatatttat ttttgagaat gattccaaac gtataaagag
    10561 gattatcttc tcctacagtc atatcgatag gaataatgtc gtatagactg tcttttccca
    10621 gtctagcttc ttctaaaatc acttcaatat caggatcatc aacaataatc ttggggcaag
    10681 gcttcttagt ataccagcta agcatcattg aatcgatctg gatgtgttca atcaaactgt
    10741 tgcacatagc cgcttctaac gttttgtgag aagctgttcc cgtagaaaat cctggtatta
    10801 tccgtctttc tcctacagtc tcatttgttt tatacccaac acaaagcatt tgagctggaa
    10861 catacatctc tgcgtcctca aagaacatgg gacatttaac ccagcccaat acatcgttct
    10921 cagttaccat tttatcgcac atcatcattt gcaagtcaca agataatgcg atctgttctt
    10981 gggtaaacac ttgcaaatat tttaaaggca tcactttatg taacagtttt aactcattat
    11041 aagaagcata gacaatacga tctgatagta agtctccggc aattacagta gcatagcgtt
    11101 caatactttc tcctaaatac ttgataagtg cttcttcata gtaactgcca taaccaataa
    11161 tgtgataact aacttgactc aactcaccta taaattgttt atgataatct ggcatttggc
    11221 cagtaatact ttttaagtaa acatcgtgag gatggttgca aactggaact tgagattgat
    11281 ttaagatacc tgttcgattg ccacttaaac tttttaattc atcaaaaata tgattaaaag
    11341 aaggataata gtataacata atagattctc cttataggtt actcgtcaag gagtttttta
    11401 acaatctcac gtgttgatat ctgctgatcc tcatacttta attttgccaa agctccttgt
    11461 gtctgtgaat tagacatttt caaaatatct tggacctgaa tctcaagcgt cggtaagtaa
    11521 atgcttaata aacgtccctc aaatttagaa ctacctgttt gagcaataat gaaagcttcg
    11581 ctaacaacta aattcattaa aacatttaac aatggtaaat aggcctggct cacatcttgt
    11641 gttgctggta aaatctgatt agcaaaatgt tgatagagag ttgagtcttg taaacgtgcc
    11701 aaaactcttc tttctaagct atcaaagtca gcactatgag gaggattcaa agtacaagcg
    11761 tgcaagaatg gtccatctac aaaaccaatc actaattgtt ttttcatagc tacgctaact
    11821 tcattcaagt gtcgcaacat cataatattc aagcgctctt gacaaataat aatactttgg
    11881 taatcgcaca aggcatctga taaacaattc atgttacggc gatgctccaa agcatctaaa
    11941 cgcgaactaa catctgtctg ctgaattaac atttttaagt catcgctagc cacttgcaat
    12001 tgtaaatgca gttgttcagc tagcaactca gcagattcat taacataagt cgaatcactg
    12061 ataaacaaaa caggatcatt gcttaccata tgacctgctt gcgccataaa acggaaatta
    12121 cccattaaaa ttttcatgac attttcttca agattgtagt catcctcaag catcagcata
    12181 tcattgtaat acaagcctga aatgacttcc attaaattag cgaacgtctc aggttctaaa
    12241 gtattttcat aagtttcagt atcaatggct actcccttaa ccaactgtga aactatttct
    12301 tgataaacta tctttaaatt ttgaggttct tgtgtcaaat ctagaatggc ttcattaaag
    12361 tcccagattc cttttctaaa acaaaatgta tcttgaaatg tcacgacacg aacattacta
    12421 ttaagttgat atttcattga gactccttag ttcctacgag tgtcatgtga atcacatgct
    12481 ctcctagccc atctaaatct aataattctt ggagatattc cttattataa ccaccaatat
    12541 caatacttcc ataagttaag gcagttgcag tcaattgaat attctgggct atttctcctg
    12601 attcaataaa agcataggca gtcgcctgat tcccatattt acgtgtattt tttatgtaat
    12661 ggtagacata aataataata atattacaat tttcagcatt aatagcaccg tattccgcaa
    12721 aatctctaac gttttcctca gagctatgcc gataacacct tagtgcatgc tgatagggta
    12781 ggtattcata gaaaccatct attaatttac tgatgtttct agcataaaaa actaaatgaa
    12841 tagggtataa acctccacct gaagcacagt ttctgagtgt aatcttatct gatgctccat
    12901 ctctaattga tgcttgtgaa ctaacaccac atgcataata aagaatgttt gataaatctt
    12961 gaagaggcat ttgtctatct gaaaattgac gatgacttct tcgttttata atacatgtcg
    13021 acagagcagt tgatatcttg gtaggttttg gtaaacgaat tatcttttcc tgactttcat
    13081 aaacgtaact acttgaaaaa ttagcaacgg cagaatctgt aaaaaagtcg acaatactag
    13141 cttggaagcc taaataatta ttattagctt tatagttcat caaaaaatgt tgactaagat
    13201 tatcggttgc attaggcatt aaatgttgag caactagctg ctttgacgtt tttagcactg
    13261 tttgatgatg gtaatccgat aaggacaagt ggtttgtatt aaattcaaac aattgccttg
    13321 ctttttcaac agttattggc ggacaattct ctttaggttg tttttccttt gtaaaaaatg
    13381 acataactat ctttcctatc tcattttact aaacatatag taattagcag gtactgtcta
    13441 gtacctgcta attacctgag acgctagcat caagaagatt acttttgtct catgttttct
    13501 aacacctcta tgccattcat ctataatcag aagttaccaa agataactta gttgctagca
    13561 aactcattac cctaatatca ctatcacata gagatgctaa atagattatt tacctggcgt
    13621 ataacttccg ctaccacctt gagaattacc acttccagta gcaattgaga agcaacaagt
    13681 agtacagcag caacagcagc ctccaggagc aacttgagtt gtttcagcta cactagtagc
    13741 taaaatattt gaagtaaatt ttaacataag gtttacctcc ttatctaata agtaactgat
    13801 aagaacacga gtcgtttatt tttaacctta ttttaaaaat aaagttaaca caacaaggac
    13861 aaggctagct caattgtact gttgtaacac aacaactatc tagttcttat cacttttatt
    13921 atagtaaaaa atgattaata tgtaaaccct ttctttttaa tattatcaaa aatgacaaaa
    13981 aaaataataa ttttctctaa aaaactatat ttttcaaaca atagcgacaa aaatgagagc
    14041 taattttcaa agctttataa cttatatcat tttgataact ctagctaata tctttacttc
    14101 atcctagata ctactttgaa atatgtaata cctggacaaa cctataccac gacgttttta
    14161 ctaaataaaa aaactttggt cctgtattat cagaaccaaa gttttttaac aagttgttaa
    14221 gtttttctca cgaatcatta actcaggata aattagccca cagtaaattt ttactattta
    14281 gaaagcaaaa agcttgggat tttcccaagc tttctattct ttaacttttg cgtcgtagct
    14341 gactggatgt tcactccttt tgtcgtgacc aacctagtca gcctgacgga ggtgcgacga
    14401 cgaaatcgca ttctacgaat gaccgatttc tgtcttaccg cctatttttt taagttatag
    14461 aatgatttga tacctttgta ttgagcaact tcaccaagtt gatcttcgat acgaagtaat
    14521 tggttgtatt tagcaatacg gtctgtacgt gacaatgaac ctgttttgat ttggccagcg
    14581 tttgttgcaa ctgcgatgtc agcgattgtt gaatcttcag tttcacctga acggtgtgat
    14641 acaacggcag tatatccagc ttctttagcc atttcgatag cttcaaacgt ttcagtcaaa
    14701 gtaccaattt ggttaacttt gataaggatt gagttagctg cattttcttt gataccacga
    14761 gcaaggtatt cagtgtttgt aacaaagaag tcgtcaccaa ccaattgaac acgtttgcct
    14821 aggcgttcag taagaacttt ccaaccatcc cagtcgtttt catccatacc atcttcgata
    14881 gtaataattg ggtatttgtt aaccaactct tcaaggtaat caacttgttc tgcagatgta
    14941 cgaacagcag cgccttcacc ttcaaattta gtatagtcgt aaactttacg ttctttgtcg
    15001 tagaattctg atgatgcaca gtcaaaaccg atcataatgc cgttttcacc agcttcgtaa
    15061 ccagctgctt caatagcttt aaggatagtt tctacaccgt cttcagttcc ttcaaattta
    15121 ggagcaaatc caccttcgtc acctacagct gtaacaagtc cgcgttcttt aagaattttc
    15181 ttaagagcgt ggaaaacttc agcaccccaa cgaagacctt ctttgaaagt aggtgcacca
    15241 actggcatga tcatgaactc ttggaatgca attggggcat ctgagtgtga tccaccgttg
    15301 atgatgttca tcataggagt tggaagaact ttagtgttga atccgccaag gtaagtgtaa
    15361 agtggcactt caagatagtc agcagctgca cgagcaacag cgatagaaac accaagaata
    15421 gcattagcac caagtttacc tttgttagga gtaccgtcaa gagcgatcat tgcacggtcg
    15481 atagcttgtt gatcgcgaac atcgtaaccg atgattgcct cagcgataat gttattaacg
    15541 ttatcaactg ctttttgagt acctagacca aggtaacgag atttgtcacc atcacgaagt
    15601 tcaacggctt catgttcacc agttgaagct cctgaaggaa ccataccacg tccgaatgca
    15661 cctgattctg tataaacttc tacttcaagt gttgggttac cgcgtgagtc aaggacttcg
    15721 cgagcgtata catcagtaat aattgacatt gtaatactct ccttatgagt tttaatattt
    15781 tacatgttca taataccaca aactaggcct ttaatcaact taaaaagcaa tctcatgaaa
    15841 agcttccttt gttttttgca agaaaaatca ctttctttct tgttttttaa cacatttacc
    15901 gaaaattttc aaattggtat tttattgtag aaatcgatat aataaagaaa ctattataaa
    15961 gaagcgaggg tatctatgac taatttagaa gataagctat taaaaggagc ctggggagaa
    16021 agaagattaa atcctgagca gcaacgctac tatctaggaa cgtatgctga acgagtcgtt
    16081 ttaagtgctt tattagacga agctcaaact aaaacagtaa aagactattt gaaaagagaa
    16141 ttaccgagcc ttcagttagt ctatcaacct ttacacttaa aaatctcttc caagctggca
    16201 cctcaacttc aaatacttta tatgaaatta gcaaaagaaa actatttacc tgttactatt
    16261 attacagaaa cgcatatgac ttcacctttt gcgtttatcc ttcataccga ccacgcaata
    16321 aatctaaagg aaacacgttt agaagtcatc ttaaagcaga caaaaaacga tcaacttagc
    16381 aaacaaactc ctgaaaaaac caaatccttt tggaaaagat ttttgaaaaa ataactatcc
    16441 tctcaatagc aaaaaacact gttactactt cttcttttga tcattaaaaa gaagattcta
    16501 gtcaaaaaca cgtattggtc caaaaagcta ataaaaagtc gtgagaatat cacgactttc
    16561 aagtatcaaa aacgaatgtg ctctcgtgtt ttttcataag agttaacaaa ccgatctgtt
    16621 accccaggtt caactgtttc aagagcataa gaaatttcat caaaagaagc ctgataatca
    16681 ttttctactt cgaaaagtct caaagcatgt tcaaaactac tttgaactcc tgcttcaaaa
    16741 gaacgatagc gattagaata ttgtagtaat tgttcagtca aggtagcatt ttgaaccact
    16801 tgataggtta aatcttctag attagcaata gcaaccgtcg caacttccga caaacgtgac
    16861 actgcctcaa tattgatccg tcctctacta agctcatcca tcaaagcttc caattgtgaa
    16921 ctcgttgtaa agaaagcact aagaaagtct tgtggaattc caggcaagtg acgtttttcc
    16981 atataacgtt taatcatatg aagctgagta acataaacat caaggttatg gcgtgcctgt
    17041 gattcaattt tttcaatatc tttaactgct gcaaaaacat ccatttgacc tgactcgaca
    17101 ttagtaagcg tctttatact gcgttcaaaa gtcacttgca gttctgaaaa tggtttttct
    17161 tgtaaaccaa attgttctgc aacagcaagt gtactgtctt cgatctcttt aatatccttc
    17221 tcaaatgcct taacagtcag actttccgtt tcacttagaa tatatttacg tgataaacgt
    17281 gcaatttcat ctttgagttg ttcattatta cgtttcacat gtgctaggta acgaggtagc
    17341 atcttactat ttttagcagc taccttataa gcggcaattt cgcgctcaaa gacttcataa
    17401 agagaatcaa tgcgttcttg aatatgcgcg ttttcttctc tagcacgatc caagtcaagt
    17461 gtaactaact ctgatgaatt ggcacgaata gactcacgaa tctcctgaaa acgtgcctca
    17521 atgttttttt ctggaaaatg atagttttct tcaagtaaac ggcgatatcc tgtttccaaa
    17581 tcatctaact gatctggaaa atcatcttcc aacttggcca caatagctgg aatctgctct
    17641 gtaatctgcc ctagagcaat agtatgctct tctgctctat ccagaacttc agaagcttct
    17701 acaggatcac ctgatgagtt gagtgcgaca aactgtgaaa attcagtttc aatgtttttc
    17761 atctgtttgt caatttcagg catagttgaa ccaaaattat cttcattctc agaaatagaa
    17821 gcttggagct tttcatataa atcaagagca tgggtgacac gagcactatt tttttcttct
    17881 tgctctttta agatattaag tgcttcacga atagaagcga tatcttcttc aacaagatta
    17941 agctgacttt caacgctatt aatctcatgc ttggcgcgaa taaaattaaa cgtatcattc
    18001 aaattttcag cttcaaaaat atgattttca atatctgcaa acgaatttac agttaagtct
    18061 acccatttct gattccattc ccgaaaagag gtttggctct gtcctatcaa atgaagtgac
    18121 tttacttctt caatttcatc attaacaggc aaagcaaaca aggcctgttt tcgttcttct
    18181 agactggtaa ttagggaatc attacgcttt cgtatgatga cacccactag ataggcgata
    18241 atcactagta ggactatagc cacaatcagc aagataattc cgcttgacat ctgaatctcc
    18301 ttattattta gacacgattt atcaacattg ttccagtaat aactaaaaac tgaaattcct
    18361 caatcgcctt ttattaaaat tttatttaaa atacactata acattacgat tataacatac
    18421 tttaaaatgc atttcaaaat atatttgact aattcaacaa tctcgtacca gcgactcaca
    18481 aggctttctt aataaggact aacataggta ttaaggggcg atctcaatac ctatgcatta
    18541 acgctgtccc tcaagatgaa gacgtactaa ctaacaaagc tgttggcatc atgcatcatg
    18601 atttttagtc aattcgtcct ctttggtagc agattccttg tgaaactaaa aaggtgacta
    18661 aatatccagt gtactataaa ccgcattttc ctcaatgaaa tcacgtcttg gttcaacacg
    18721 atctcccatt aacatatcaa atactttatc tgcttctgcg gcatcatcaa ctgtcacacg
    18781 cgccatcaaa cgattttcag gatccatagt agtttcccaa agttgatggt catccatttc
    18841 cccaagacct ttataacgtt gaacagttgg ttttgaacga ccaatactat atttttcaag
    18901 agctgttttt aattggtctt cttgatcaat acctggctga atatactctt taatctcact
    18961 accgacctta acaccataaa taggtggctg ggcgatataa acatagccag cttctagaac
    19021 aggcctcata aagcggtaaa tcaaggttaa aagcaaggtt ctaatatgag cgccatccac
    19081 atcggcatcg gtcatgataa ccagcttttg gtagcgagct tttgacacgt caaaatctgc
    19141 accaaaacct gtacccatag cggtaaaaag acttctaatt tcttcgttgg caagaatctt
    19201 atccatagtt gctttttcca cgttcaaaat tttaccacga ataggcaaga tagcttgaaa
    19261 ctctcggtta cgacctgatt tggccgaccc acccgctgaa tctccttcga cgatgaaaag
    19321 ttcgttttgg ttagcatcat ttgacgaaca gtctgctaat tttccaggta agtttgaaat
    19381 ttctaagcct gattttttgc gggtgacttc gcgggctcgc ttagctgcaa ttctagcttt
    19441 agaagccaaa atcccttttt ccacaatctt acgagcaact tgtgggtttt ccaaaagaaa
    19501 acgttgaaag gcctcactaa agagacgatt agtgatctta accacttctg agttgcccaa
    19561 ttttgttttg gtttgacctt caaattgagg atttggatgc ttaacagaaa ttaccgccgt
    19621 caaaccttca cgaacatctt ctcctgtcaa attgtcctca ttttctttaa gaattttatt
    19681 tttcttagcg tagtcattga tgacccgagt aagagccgct ctaaagcctt gttcatgcgt
    19741 tccaccttca tgagtatgaa tattattagc aaaactcatg actgtttctt gatagctagt
    19801 cgtgtattgc atggctactt caactgcaat accttctaat tcaccatctg tatagatagg
    19861 cgtttcaaag ataacatctt ttttatcatt taaaaattca acataagaac caattccacc
    19921 ttcataatgg aaatgttctt cttgttccat acctgagcgc ttatctgtaa tggaaatttt
    19981 taaaccacga ttcaaaaagg ctaactcttg aatacgtttt gctaaaacac tgtaatcaaa
    20041 ctgagtcgtt tcagtaaaaa tttctggatc gggtgtaaag tgtaccgttg ttccagtcac
    20101 atcagtggtt ccaatgatct caagatctgc tacaacagcc ccgcgtttaa attcttggta
    20161 atgaatttgg ccgtttttat aaacacgcac atctaattgt gttgataaag cattaacaac
    20221 agatgaccct acaccatgta gtcctccaga aaccttatag ccgcctccgc caaatttacc
    20281 acctgcgtgt aagactgtaa aaactgtttc aacggcggga cgtcctgtct tggcttggat
    20341 gtcaactgga attccacggc catcgtctac tactgtaatg gaattatctg cttcaataaa
    20401 gactttaata tgagaggcaa aacctgctaa tgcttcgtca attgagttgt caacaatttc
    20461 ccagactaaa tgatgcaaac cctctttagc tgtcgagcca atatacatcc ctggacgcat
    20521 tcggacagcc tccagccctt ctagaacctg aatttgactg gcatcgtatt cttgcatttt
    20581 tttttcaaaa tgtttatttt cttcaatcat ctacgttact atctccaata ggttttttct
    20641 accgtcaaca agcaaggtat taaaacccgc tgcttgtcct gcttgtttat caattagccg
    20701 atctccaatt actaatccac tattaatatc atacttttct tttaaataaa acaaactttc
    20761 aggatttggt ttccgagcaa agccatttga agctgtcacg acttctgtaa aatagattaa
    20821 caacccagct tgctctaaaa gttggttcac ctgacaatct cgatgagaaa ttaaaaaatt
    20881 tcgcgaacct gaagtcgcta tcttttccaa aatttcttta gctcccaaac accaaatggg
    20941 ttgtgccaat ttgtctgctt ctcttagcct atacacatgc aaaaattctg gctcattagg
    21001 agcaaacgtt gccacagcga tagcggttga ttcttttaat ttttggtaaa cagcatcgtg
    21061 atctcctgga aggctgaaaa aagctagcgt ttggacaaaa gcttgggttg aaagctcgta
    21121 attatcgagt aaggtacctc ccaaatccca tatataatct tgataattca tacctttcat
    21181 tatatcacaa attcacttaa tattatagtt atttcccaaa taaaacaggt atcgtaatga
    21241 ctgaataaac gagtcttgcg atgttctatt cctctaatgg taacacatac acctctttag
    21301 ctgctccttt cctttttgat ctccagaaag tatgcactga taattcataa acagtaccaa
    21361 gcccactcta atcaagttag aaatcaaagc tgatcttctt taggagacaa aaggcaggga
    21421 aattcctgtc aatagtaaaa tgccaataga agcaccgcta ttttccaata tgataaatcc
    21481 tgttgaaata tatgtataaa aaatgattta atttaaatgt cacttttaac atacgataga
    21541 ttaatcacaa gcagagtgct aacagctttc catattcaaa aggtttacca attttaaacg
    21601 cgtacatcaa taagcgattg aaaatttacg gagattatca cacgcactta tttagacact
    21661 cgcacatttc gcttttagct gaaaaaggat taccaccaaa agtggttagg gacaggttta
    21721 gtcactcaga ccctaactta agattgtcca tttatagcca tacatctgta aatagggagg
    21781 aattggttaa taatcgaact gcctcttttg tgctcctaac attaattgag taatacaaaa
    21841 aagcctttga tgtaaaggct ttttcagtga caataatgac ccctgccgga atcgaaccag
    21901 caactactcc ttaggaggga gttgttatat ccattgaact aaggggtcta tcttatattc
    21961 accttgtctt ctattttaac ctagaaaata aggtaatgca agatgaaata tcagataact
    22021 gaaagtttat tttgcttcat tttgttatta caatatacta attataactg ctaaggaact
    22081 ttcaaagtgt cctacgagca tagcgttaat caccaattgt cacattgtca cgacgacata
    22141 aaaagactag agactctagt ctttttattc tattacgtta cgtttcggtt caaactaacg
    22201 acgaatttct ttgatacgag cagctttacc ttgtaatgca cgcaagtagt aaagtttcgc
    22261 acgacggact ttaccgtggc ggataacttc gattttgtca acacgtggtg tgtggattgg
    22321 gaatgtacgc tctaccccga taccacctga gattttacga acagtgtaca tttctgagat
    22381 cccttgacct ttacgtgaaa taacaacacc ttcaaagatc tggatacgtt cgcgagttcc
    22441 ttcgacaact tttgcgtgaa cgcgaacagt gtcaccagga cggaagttag ggatatcaga
    22501 gcgaagttga ccttctgtca aactttggat taatggattc atttttattc tcctatctta
    22561 ctaatcttaa gtacttgtct tagcggatta gccgtaattt ttgtgtgtcc attacacacg
    22621 agatttattc taacaaaaag cttctttatt gtaaagctat ttttttaaat ccatctgatt
    22681 taccgtcatg tcttttaaat tgatcatgac tactttttga taactgtaaa tggaatgtct
    22741 gtgactaacc atataggctg cagccgaggt gacaaaatat gctagggcat tctctggacc
    22801 aaagacctct atcccaataa agataggggc ccaaaaggta tttgttgcac ttccaaatac
    22861 cgtgacataa ccaagtgcag caaccaacag tacaggaagc cctaagtaag gggccaaaac
    22921 gatgcctaaa gaagctccaa tagcaaatag aggcgtcact tcaccacctt gaaagcctgc
    22981 agataagcta atcaccgtca cgatcatttt taaaagccag tcgtaagtta ggatagtttg
    23041 gccagaaaaa gctgccgcaa tcaaatgagt ccctagacca ctatatcttc caacgtgacc
    23101 aatcatcaaa cagatagata acaaaacacc aatgaaagca atccggagat aaggatttgg
    23161 tagcttttga ctcaggtaag gtttaaacca gccaagtaaa caggcaaaac tatttcccac
    23221 cagaccaaaa ataagaccta acccaattaa tttaactaag gttaagggag ttatggtcaa
    23281 tgtttcttca agaacaatcg taaatttctc taatcccaaa gaatgagagg tccaagaagc
    23341 cacgcaagca gcaactaagg aaggtaataa agcgcagtag cgaagcgttc ctaccaacaa
    23401 aacctcaagg gcaaatacga cagcagcaat tggcgtttga aaaagtcctg caaaaccggc
    23461 tgccatcccc ataatcaaaa gatgtcgtgc ggcttcttga ctagtcacaa atctccgaca
    23521 ataatgagag atggtagctc ctatttgaac ggctacccct tctcgacccg cactcgctcc
    23581 aaataagtgg gttacccaag tcgataacaa aataagagga atgagaatag gaggaatctg
    23641 atctttttga ccatgcccta cctgaaaaac caatcccatc ccttgacgaa cctctttgcc
    23701 taacttatca taaagaaaaa cgataacaag gcctgctaag gcaagaaaag gaagaagcaa
    23761 gaaaagg
//
