LOCUS       NZ_CAAHKQ010000009     23767 bp    DNA     linear   CON 11-MAY-2024
DEFINITION  Streptococcus pyogenes strain A904, whole genome shotgun sequence.
ACCESSION   NZ_CAAHKQ010000009
VERSION     NZ_CAAHKQ010000009.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (03-APR-2019) WTSI, Pathogen Informatics, Wellcome Trust
            Sanger Institute, CB10 1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900983695.1-RS_2024_05_11
            Annotation Date                   :: 05/11/2024 02:54:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,776
            CDSs (total)                      :: 1,717
            Genes (coding)                    :: 1,662
            CDSs (with protein)               :: 1,662
            Genes (RNA)                       :: 59
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 50
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 55
            CDSs (without protein)            :: 55
            Pseudo Genes (ambiguous residues) :: 0 of 55
            Pseudo Genes (frameshifted)       :: 29 of 55
            Pseudo Genes (incomplete)         :: 29 of 55
            Pseudo Genes (internal stop)      :: 25 of 55
            Pseudo Genes (multiple problems)  :: 23 of 55
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 15:26:47
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 62406
            Orig. end                         :: 86173
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CAAHKQ010000009.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23767
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="1"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..23767
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23767
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13767](+)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13767
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     misc_feature    complement(66..77)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     gene            complement(155..1696)
                     /locus_tag="E9664_RS05600"
                     /old_locus_tag="SAMEA3919112_01100"
     CDS             complement(155..1696)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011284650.1"
                     /locus_tag="E9664_RS05600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_01100"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_136048177.1"
                     /transl_table=11
                     /translation="MLHLHLETKLQDKLSLLNILLDVSEVSIDQLCQETELKKQRVYNL
                     LIEMIKDLEDTLTLTICDDTVSIPYKIYQLKMPYFKKLYQTSIFLKMLCFLIEPGELSL
                     HDFIKREYISQATAYRIRTNCRKYLKKVGLNVRQNHVVGPEYRIRFLIALLHYQFGMTI
                     YDFDKTSMNKVVSLIINSNQAITLNDASKAPYEFSYFAILISLIWKRRHDNLGIPQTDA
                     FKHLKKLSIYRDIKMTSQEIIGKWYHPELTDEDLDYIFLCFCTTNNPFHKDKWTPKKVK
                     ELFELVMTKTNGKTLKASLRPLLGNNILNSLPFKRILVSFSRLFISNLQVLLPDIHLFH
                     YLRRQQKRNKSFYNTLKTIVEEWMSAEGIVGKLPSYHLLLFTIQLEELLKTYLPPIPVY
                     LLTNNTAALDLMTNALSIYFPPAIATVMPVNVEIIPFKDIVKEKQSVIIADRQYLNLIQ
                     HLYQNQGHLFLYFLFSFRDVSEAYIHKAFLDFRQKRYDEFIVTLLDTYHKNLSSP"
     gene            2168..>6259
                     /locus_tag="E9664_RS09240"
     CDS             2168..>6259
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019202.4"
                     /locus_tag="E9664_RS09240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF1542 domain-containing protein"
                     /protein_id="WP_168389335.1"
                     /transl_table=11
                     /translation="MFLKHQDVKQKNWRMRKVKKLFVSSCMLLTVGLGVAVPTAFSQSN
                     GVMVVKAAEVPAVDEVKTDGNPNNMLDYSYHLTFNDSKAGGRYYTNDKSVNPTDLNLKY
                     FYVHGKKVRENDRLYKYEGGKEIHDSSIGVYNQRYKIVSYMFYSGSKAMTTVYRVNSKP
                     LKPEHNYSFEFGQDVNEAKPEKANTFGLEVGYGFGTKYQKGDVSSYKAITPEHLGLKDV
                     KVIENGKESDDLSIKVRANEKKKITFKSEKSDTPSLLVYTRTKGANTRQDYINFRDFQF
                     YDVTEPDMYKSNSGVAHAGHDKVTLELDTLKGRDALIDQTVTVYNGNETLGTKAIILNS
                     KDKKLTIDAKSLKKAKTGDVIKVKILQSDSKKYRETTFKVTFDPKDVQEQKKLLTDTKA
                     TAFKINNMNPWLSNSEKSLANTKVNETFAQEFKKLEEALNSEGLTLDSLKEKASVSVGK
                     INSPEQLEVTKARKIKEAEAAINAKYDKVNQQLSEDKTIKASEKPEFEKELAKLKEEAL
                     KGLSGATDLRTLNERQYNGEKSLTYETGKPISEQKTAALDELQKKHVETLMSIKEDTGL
                     SKSEKESQKAEANNAFEAAKARINSNEVDDADKLQTAKIEGQNAITNAYVKGDLEKYKK
                     AKLTELEEAITKEREVITTDASLTTLQRKAKLKELEEVAQTAKTAINEPDNADDVLQAL
                     QVHVPKVKAVHTPGKIEDVKKSATDSLNKILKETLSSIEGDKSLTQAEKDKQVQDAQKV
                     FDESKKKIEKATDADKVLEFKNKAEEAIPETHQKGNLEGIQTAQKAELKKVHDETVAEI
                     EKDNGLTKTEKNAQKTKAAEALKKGEEAVQSATTADEAIAKAEENKKIITVTHEKGDLA
                     KVKDKAKEGLTATYNKTVKNIKADSGLTADEQKKQLEGTEKAYKAGEQAITTAENADKV
                     GEVLPVEKKKVSDEYKAGDLPKVKQAQKDALQKVHDETIAQVEKDKGLTTEQKDAQKAK
                     AAEALKKGQDAVEAAPKADEAIKAGTDNQQPIKDSYIPGKLDDVQTKATADLKKAHTET
                     VAKINGDDTLDKATKEAQVKEADKALAAGKEAITKADDADKVSTAVTEHTPKIKAAHKT
                     GDLKKAQEEANTALDKAAEKEREEINNDITLTAKDKEQQLKEVETALTKAKDNVKAAKT
                     ADAINDARDKGVATIDAVHKAGQDLGARKSGQVAKLEEAAKETKDKISADPTLTSKEKE
                     EQSKAVDAELKKAIEAVNAADTADKVDDALGKGVTDIKNQHKTGDPVVARREAHGKQLD
                     RVAQETKDAIEKDPTLTTEEKAKQVKDVDAAKERGMAKLNEAKDADALDKAYGDGVTSI
                     KNQHKSGDPVEARRGLHNKSI"
     assembly_gap    6260..6626
                     /estimated_length=367
                     /gap_type="unknown"
                     /linkage_evidence="unspecified"
     gene            <6627..9136
                     /locus_tag="E9664_RS09245"
                     /old_locus_tag="SAMEA3919112_01101"
     CDS             <6631..9136
                     /codon_start=3
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285469.1"
                     /locus_tag="E9664_RS09245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_01101"
                     /product="DUF1542 domain-containing protein"
                     /protein_id="WP_168389336.1"
                     /transl_table=11
                     /translation="LTEAEKETQRGNVDKEATKAKEELAKAKDADALDKAYGDGVTSIK
                     NQHKSGKGLDVRKDEHKKALEAVAKRVTAEIEADPTLTPEVREQQKAEVQKELELATDK
                     IAEAKDADEADKAYGDGVTAIENAHVIGKGIEARKDLAKKDLAEAAAKTKALIIEDKTL
                     TDDQRKEQLLGVDTEYAKGIENIDAAKDAAGVDKAYSDGVRDILAQYKEGQNLNDRRNA
                     AKEFLLKEADKVTKLINDDPTLTHDQKVDQINKVEQAKLDAIKSVDDAQTADAINDALG
                     KGIENINNQYQHGDGVDVRKATAKGDLEKEAAKVKALIAKDPTLTQADKDKQTAAVDAA
                     KNTAIAAVDKATTADGVNQELGKGITAINKAYRPGEAVKARKEAAKADLEKEAAKVKAL
                     IAKDPTLTQADKDKQTAAVDAAKNTAIAAVDKATTAEGINQELGKGITAINKAYRPGEG
                     VKARKEAAKADLEKEAAKVKALITNDPTLTKADKAKQTEAVAKALKAAIAAVDKATTAE
                     GINQELGKGITAINKAYRPGEGVKARKEAAKADLEKEAAKVKALITNDPTLTKADKAKQ
                     TEAVAKALKAAIAAVDKATTAEGINQELGKGITAINKAYRPGEGVKARKEAAKADLEKV
                     AKETKALISGDRYLSETEKAAQKQAVEQALAKALGQVEAAKTVEAVKLAENLGTVAIRS
                     AYVAGLAKDTDQATAALNEAKQAAIEALKQAAAETLAKITTDAKLTEAQKAEQSENVSL
                     ALKTAIATVRSAQSIASVKEAKDKGITAIRAAYVPNKAVAKSSSANHLPKSGDANSIVL
                     VGLGVMSLLLGMVLYSKKKESKD"
     gene            complement(9322..>9438)
                     /locus_tag="E9664_RS05610"
                     /pseudo=""
     CDS             complement(9322..>9438)
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611995.1"
                     /locus_tag="E9664_RS05610"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="IS3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="QETFYSLEQLTLKTKEEVHWWNYHHLHSNLNYQTPITK"
     gene            10001..10162
                     /gene="sagA"
                     /locus_tag="E9664_RS05615"
                     /old_locus_tag="SAMEA3919112_01102"
     CDS             10001..10162
                     /codon_start=1
                     /gene="sagA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03602"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985285.1"
                     /locus_tag="E9664_RS05615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_01102"
                     /product="TOMM family cytolysin streptolysin S"
                     /protein_id="WP_002985285.1"
                     /sec_met_domain="TIGR03602 (E-value: 1.1e-30, bitscore:
                     98.4, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKFTSNILATSVAETTQVAPGGCCCCCTTCCFSIATGSGNSQGG
                     SGSYTPGK"
     misc_feature    complement(10169..10186)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 22.53"
                     /tool="antismash"
     gene            10384..11334
                     /gene="sagB"
                     /locus_tag="E9664_RS05620"
                     /old_locus_tag="SAMEA3919112_01103"
     CDS             10384..11334
                     /codon_start=1
                     /gene="sagB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922108.1"
                     /locus_tag="E9664_RS05620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_01103"
                     /product="streptolysin S biosynthesis dehydrogenase SagB"
                     /protein_id="WP_010922108.1"
                     /sec_met_domain="PF00881 (E-value: 6.8e-34, bitscore:
                     110.2, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFFTKEQQPKENCPPITVEKARQLFEFNTNHLSLSDYHHQTVLK
                     TSKQLVAQHLMPNATDNLSQHFLMNYKANNNYLGFQASIVDFFTDSAVANFSSSYVYES
                     QEKIIRLPKPTKISTALSTCIIKRRSHRQFSDRQMPLQDLSNILYYACGVSSQASIRDG
                     ASDKITLRNCASGGGLYPIHLVFYARNISKLIDGFYEYLPYQHALRCYRHSSEENVRDF
                     AEYGAINAENCNIIIIYVYHYMKNTRKYGNQATAYAFIESGEIAQNIQLTATALTYGSI
                     DIGGYNKEYLQELLDLDGLGEHVIHMTLVGTKESQ"
     aSDomain        11331..11600
                     /aSDomain="Cytolysin_C_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing discrete C protein in a
                     SLS/cytolysin LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_E9664_RS05625_Cytolysin_C_RRE.1"
                     /evalue="4.50E-42"
                     /identifier="RREFam014.1"
                     /label="E9664_RS05625"
                     /locus_tag="E9664_RS05625"
                     /protein_end="90"
                     /protein_start="0"
                     /score="133.3"
                     /tool="antismash"
                     /translation="MKYQLNSNVRVVTFQDTFCFRKGIWDFNEAILDLTQEPQNLKIVY
                     QEIVSQLVKGVAIDTETYENALEPETFANLMEVISGLYYNDMLML"
     gene            11331..12389
                     /locus_tag="E9664_RS05625"
                     /old_locus_tag="SAMEA3919112_01104"
     CDS             11331..12389
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03603"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cytolysin_C_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985275.1"
                     /locus_tag="E9664_RS05625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_01104"
                     /product="streptolysin associated protein SagC"
                     /protein_id="WP_136048178.1"
                     /sec_met_domain="Cytolysin_C_RRE (E-value: 1.8e-41,
                     bitscore: 133.3, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03603 (E-value: 9.7e-141, bitscore:
                     461.7, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYQLNSNVRVVTFQDTFCFRKGIWDFNEAILDLTQEPQNLKIVY
                     QEIVSQLVKGVAIDTETYENALEPETFANLMEVISGLYYNDMLMLEDDYNLEENVMKIL
                     MGNFRFMAQAGHMVSNDPVLFISDSTYVNESAELLAEQLHLQLQVASDDLKMLIQQTDV
                     SSRLDALEHRRNMNCLSEALCDYQSIIICQERLNIMMLRHLNEVSVAMKKQLVIGFVDG
                     PFLHTCTLNPPHSADFDSLERRVLARLQDSTLYQHFANQVLPATQDVSQAYLPLLNVLM
                     NLVVSEAFIIAQTGSSKFEGRLLSIYLPTLEIQVQDILKMSNSQTQGALAKLKYEDQQI
                     STREIVKKLLDE"
     gene            12409..13767
                     /locus_tag="E9664_RS05630"
                     /old_locus_tag="SAMEA3919112_01105"
     CDS             12409..13767
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407460.1"
                     /locus_tag="E9664_RS05630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_01105"
                     /product="YcaO-like family protein"
                     /protein_id="WP_002990434.1"
                     /sec_met_domain="YcaO (E-value: 4.2e-64, bitscore: 210.1,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 2.5e-112, bitscore:
                     368.2, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLYYYPSFNHIFDELKSLSGNRTGILNQSQVPVCNHPHDVYLKSI
                     TGQMPDYHKQFIGELSQVSYHIIGYGSYYEEALIKYLGESIERYATVIAGDLLSDRIVY
                     ASYNELKLLHKVMPLEYLQVFTQEQIALSCDLQMMMCDKMVTENDVLGWVKCPMFFEDA
                     EMYVPAQMLCVGYKTNETVGERRIIPGFSTGTASHKTLEAAMCNSLIEYIQIDSMMLSW
                     YTKKPCPKIIVDDPDIEVILEEARLGKDSLYDIIPIDMTVGEDNPLYTFGIILKNKYDE
                     GPYLLFGVQAGLDPKHALLRGIMEASAISYSYYYNLLYQKASLANIECEEPLFLDLDSN
                     VFYYAHPKDQDHKWKAFEPLISGEVLLSDLEDHSGKDKKEDLKTLLAYAKKVSPNAVFL
                     DITPPEALEKGWYVTRVLMPELLEMCIPAFPFANHPRMRQFGGVTNAFVHPMP"
     gene            13742..14413
                     /locus_tag="E9664_RS05635"
                     /old_locus_tag="SAMEA3919112_01106"
     CDS             13742..14413
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017602.1"
                     /locus_tag="E9664_RS05635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_01106"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_002994083.1"
                     /sec_met_domain="Abi (E-value: 7.7e-10, bitscore: 32.0,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLSIQCLNLCFLLVTFCPSIPMQAIFGKEDSGYAFNLIGFLRAT
                     LIYDILALVSIYVLSPQITLSLESIDSKTFFMGLVFCVFIVLIELVFLHGLRCWQKKQW
                     LPATFSFVGTTNDWSKIGYPLLLALFEETIYRFLWFNILAFQWHLPTIIVLIVTSFCYA
                     LNHLLMGKSIFYAKLVTGIIYGSIYMLTSQLWLVVIMHVGGNLLVECLSHLQTKKKKEV
                     T"
     gene            14410..15093
                     /locus_tag="E9664_RS05640"
                     /old_locus_tag="SAMEA3919112_01107"
     CDS             14410..15093
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985270.1"
                     /locus_tag="E9664_RS05640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_01107"
                     /product="SagF family protein"
                     /protein_id="WP_023611471.1"
                     /transl_table=11
                     /translation="MMLLVLLSFLGLTTLWLTSYRRRCLARWHLQWLMALSYQDFLDVL
                     LSLFQFVVIILVLFFYSATINLGEVLTFLTQTSWHWQILCYLVLYLMAIIEMTLLVLIL
                     IFDVLLQKDSRLLFKKITWLPFRQDKPVLSILLLGIAILVDSLFYLGLLILLGEQSLTS
                     LATLILGYGIVKACRYSGWLNVLLAFCLFTIVGLWAVTATLLYGWLVGAMILTVTYLMI
                     SCKEY"
     gene            15116..16039
                     /locus_tag="E9664_RS05645"
                     /old_locus_tag="SAMEA3919112_01108"
     CDS             15116..16039
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017604.1"
                     /locus_tag="E9664_RS05645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_01108"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_002990429.1"
                     /transl_table=11
                     /translation="MSFVQLTNVVKSYKNGKKAVNDVSLSIEAGNIYGLLGPNGAGKST
                     LINLILGLIPLSSGKITVLGQSQKTIRKISSQIGYVPQDIAVYPDLTAYENVELFGSLY
                     GLKGAQLKKQVLKSLEFVGLHSQAKQFPSQFSGGMKRRLNIACALVHSPKLIIFDEPTV
                     GIDPQSRNHILESIRLLNKEGATVIYTTHYMEEVEALCDYIFIMDHGQVIEEGPKFELE
                     KRYVANLANQIIVTLTDSRHLELADKPDWSLIEDGEKLMLKIDNSDMTSVVHQLTQANI
                     TFSEIRHNHLNLEEIFLHLTGKKLRD"
     gene            16048..17175
                     /locus_tag="E9664_RS05650"
                     /old_locus_tag="SAMEA3919112_01109"
     CDS             16048..17175
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985266.1"
                     /locus_tag="E9664_RS05650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_01109"
                     /product="SagG family ABC transporter permease subunit"
                     /protein_id="WP_014407462.1"
                     /transl_table=11
                     /translation="MVLFHLIKKESLQIFRNRTALLMMVIFPILMIVILSFAFKSSFNT
                     ATTVPKLTIRYQLEGEKTDYQKNFLAFLKVLNQKLHLEAKPSNSLEKDRQRVSEGALTA
                     VLEVKKNQTIKVITNNINQQNADLINMLVKNYVDNAKTYDSIAALYPQQLNHIRKRSVD
                     YVKVSSIQTSKGMTSADYYAISMFTMITFYSMMSAMNLVLSDRQQRITNRIHLTGVSPS
                     LLVFGKLIGAMLATTVQLSLLYIFTRFVLRVNWGTNEWMLIGITASLVYLSVAVGIGLG
                     ISIKNEAFLTVASNTIIPIFAFLGGSYVPLTTLHSSIINQLSNISPIKWVNDSLFYLIF
                     GGQYNPIPVTLIVNISIGTIFIILALIGMRKQVTT"
     gene            17172..18290
                     /locus_tag="E9664_RS05655"
                     /old_locus_tag="SAMEA3919112_01110"
     CDS             17172..18290
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990425.1"
                     /locus_tag="E9664_RS05655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_01110"
                     /product="ABC transporter permease"
                     /protein_id="WP_010922112.1"
                     /transl_table=11
                     /translation="MICFIKTLFVKIKRKKTSYVTFFLMPILTTLLALSLSFSNNNQAK
                     IGILDKDNSQISKQFIAQLKQNKKYDIFTKIKKEHIDHYLQDKSLEAVLTIDKGFSDKV
                     LQGKSQKLNIRSIANSEITEWVKAQTNYLLENYNIIGDVALGNEDTFNRILQKNQQLNY
                     DVKQVTLTDRSRSKAVSSTTTGFLLILMLGSTSVIYSGILADKSSQLYHRLMLSNLSRF
                     RYMLSYVCVGFVAFTIQIVIMLSLLKVFNISFFVPTSLLLIIFFLFSLLAIGFGLLIGA
                     ITQNSQQSSQLANLIVMPTSMLAGCLWPLSITPSYMQAIGKLLPQNWVLSAIAIFQSGG
                     TLSQAWPYLLALMGTALALISFSSLLLKPTKL"
     misc_feature    complement(18297..18310)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 24.45"
                     /tool="antismash"
     misc_feature    complement(18523..18541)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 23.83"
                     /tool="antismash"
     misc_feature    18525..18539
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 23.65"
                     /tool="antismash"
     misc_feature    complement(18527..18538)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 18.98"
                     /tool="antismash"
     misc_feature    complement(18644..18659)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.72"
                     /tool="antismash"
     gene            18861..21593
                     /locus_tag="E9664_RS05665"
                     /old_locus_tag="SAMEA3919112_01111"
     CDS             18861..21593
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985259.1"
                     /locus_tag="E9664_RS05665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_01111"
                     /product="SpnA family nuclease"
                     /protein_id="WP_136048179.1"
                     /transl_table=11
                     /translation="MINKKCIISVSLLTLAITLTSVEEVTSRQNLTYANEIVTQRPKRE
                     SVISDKSNFPVISPYLASVDFGERKTSLPTPDKGVKVTTEQSIAQVRKGPEERTYTVTG
                     KITSVINGWGGYGFYIQDSEGIGLYVYPQKDLGYSKGDIVQLTGTLTRFKGDLQLQQVT
                     AHKKLELSFPTSVKEAVISELETTTPSTLVKLSHVTVGELSTDQYNNTSFLVRDDSGKS
                     IVVHIDHRTGVKGADVVTKISQGDLINLTAILSIVDGQLQLRPFSLEQLEVVKKVTSSN
                     SDASSRNIVKIGEIQGASHTSPLLKKAVTVEQVVVTYLDDSTHFYVQDLNGDGDLATSD
                     GIRVFAKNAKVQVGDVLTISGEVEEFFGRGYEERKQTDLTITQIVAKAVTKTGTAQVPS
                     PLVLGKDRIAPANIIDNDGLRVFDPEEDAIDYWESMEGMLVAVDDAKILGPMKNKEIYV
                     LPGSSTRPLNNSGGVLLPANSYNTDVIPVLFKKGKQIIKAGDSYKGRLAGPVSYSYGNY
                     KVFVDDSKNMPSLMDGHLKPEKTNLQKDLSKLSIASYNIENFSANPSSTKDEKVKRIAE
                     SFIHDLNAPDIIGLIEVQDNNGPTDDGTTDATQSAQRLIDAIKKLGGPTYRYVDIAPEN
                     NVDGGQPGGNIRTGFLYQPERVSLSDKPKGGARDALTWVNGELNLSVGRIDPTNAAWKD
                     VRKSLAAEFIFQGRKVVVVANHLNSKRGDNALYGRVQPVTFKSEQRRHVLANMLAQFAK
                     EGAKHQANIVMLGDFNDFEFTKTIQLIEEGDMVNLVSRHDISDRYSYFHQGNNQTLDNI
                     LVSRHLLDHYEFDMVHVNSPFMEAHGRASDHDPLLLQLSFSKENDKAESSKQSVKAKKT
                     SKGKLLPKTGDSLVYVITLLGTASLLVPILLLTKGKKES"
     regulatory      21758..21873
                     /bound_moiety="preQ1"
                     /db_xref="RFAM:RF01054"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF01054"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="PreQ1 riboswitch class II; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            21871..22371
                     /locus_tag="E9664_RS05670"
     CDS             21871..22371
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985256.1"
                     /locus_tag="E9664_RS05670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="QueT transporter family protein"
                     /protein_id="WP_002985256.1"
                     /transl_table=11
                     /translation="MTKLTVHDYVHIGLVAALYVVLTITPPLNAISYGMYQFRISEMMN
                     FLAFYHRKYIIAVTLGCMIANFYSFGLIDVFVGGGSTLIFVTLGVILFSKYQKDYLFNG
                     IFNKAFVYFSFFFATSMFTVAIELYFFGAPFLLTWFTTALGELVSLLIGSLIIDKLSQR
                     ISF"
     misc_feature    complement(23599..23613)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.38"
                     /tool="antismash"
     misc_feature    23625..23636
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.03"
                     /tool="antismash"
ORIGIN
        1 taatctcaat gccctaacaa tccatcagtc gaacggtatt tctcaaatta ctgcagttga
       61 ctcttgcgtt cagttccctc accttgtgga tgccgtttag aacaatatta gcttgctgag
      121 ccttttggta atgtgaacaa agcatcttta tcactcaagg agaagacagg ttcttgtggt
      181 aagtgtccaa caaggtcacg ataaactcat cgtaccgttt ttggcggaag tctagaaatg
      241 ccttatgaat gtaagcctca gaaacgtctc taaaactaaa caagaaatac aagaacaaat
      301 gcccttgatt ctggtacaaa tgctgtatca ggttcaggta ttgcctatct gcgataatga
      361 cactctgctt ttccttaaca atatctttga aaggaatgat ttcgacattg acaggcataa
      421 ccgttgcaat agctggcggg aagtaaatcg agagtgcatt ggtcatcaaa tccagcgcag
      481 cagtgttatt ggtcaaaaga tagacaggta ttggtggcaa atatgttttt aggagttcct
      541 ctaactgtat cgtgaagagc aataaatgat aagacggcag tttccccacg atgccttctg
      601 cgctcatcca ttcctcaacg atggttttta gagtattgta gaagctcttg tttcgttttt
      661 gctgtcttct gaggtaatgg aacaagtgta tatcaggtaa caaaacttga agattactga
      721 taaatagacg tgagaaggaa accaaaatcc gtttgaaagg aagggagttt aggatattat
      781 tgcctagtag tggacgcagg gatgctttca aggtttttcc atttgttttt gtcatcacca
      841 actcaaacaa ttctttcact tttttaggtg tccatttatc cttatggaaa ggattattgg
      901 tggtgcaaaa acataagaaa atataatcca aatcctcatc agttaactca ggatggtacc
      961 attttccgat gatttcctga ctggtcattt tgatatctcg atagatagac agttttttca
     1021 agtgtttgaa tgcatctgtc tgagggatcc ccaagttatc atgtcgccgt ttccatataa
     1081 gggatatcaa aatggcaaag tatgaaaatt cataaggggc tttactggca tcattaagtg
     1141 tgatggcttg attggagttt ataatcagcg aaaccacttt attcattgat gttttatcaa
     1201 aatcataaat ggtcatacca aactgatagt gcaacaaggc gatcagaaag cggatacggt
     1261 attctggtcc aacaacatgg ttttgccgaa cgtttaaacc tacctttttc aagtatttcc
     1321 gacaattggt cctgatacgg taagcggtgg cttgggaaat atactctcgt ttaatgaagt
     1381 cgtgtaggct cagctctcct ggttcaatta aaaaacataa catctttaag aatatcgagg
     1441 tttgatagag tttcttaaaa taaggcattt taagttggta gatcttatag gggatagaaa
     1501 cagtgtcgtc acaaatggtt aaggtgaggg tgtcttctaa atctttaatc atttcaatga
     1561 gtaagttgta gacacgttgt tttttgagtt cggtttcctg acacaactgg tctatggaga
     1621 cttcggaaac gtctaacaaa atgttgagca gtgataattt atcttgtaat ttggtttcta
     1681 gatgaaggtg taacataact gaactccttt catttttata gcagaaactc gtatttattt
     1741 aattatcaca taattaaata aaacagtcaa ataattcaat ggtgacgcgt gtttaaggat
     1801 tattgagaat gtcagatata agcaaaatgc agctgaatat tcttaatttt aggtatgaaa
     1861 aagcgtcggg attgataaaa aatctattga attgggtaaa tttaagttga tataataagt
     1921 tgattagaaa aattaataat tcatttaaat tctaatcagc tgtaacgttc cggggcgtgt
     1981 taaactgtct gaacatagaa aatacaggtt tctacggtga ctaaaataag ttaaggagga
     2041 ttccttaaat tctgtgatag gaacgtaaac tctctacaag agtagagcac gtcatcagtc
     2101 agtctgggtg tctactggct gacaacgtca aataagatag gcatgaaaaa ataaggggga
     2161 atacagaatg tttttaaaac accaagatgt gaaacaaaaa aattggagaa tgcgtaaggt
     2221 caaaaaactc tttgttagtt catgtatgct tttaacagtc ggcctcggag ttgccgtacc
     2281 tactgcattc agccaatcta atggcgtgat ggtcgtaaag gctgcggaag tgccggcggt
     2341 ggatgaagtg aagactgatg gtaatccaaa taatatgctt gattattcat accatttaac
     2401 ttttaacgat tctaaggctg gtgggaggta ctatacaaat gacaaaagtg ttaatccaac
     2461 tgacttaaat ttaaaatatt tttatgttca tggtaaaaaa gttcgtgaaa atgatagatt
     2521 atacaaatac gaagggggaa aagagattca tgattccagt ataggtgttt ataatcaaag
     2581 atataaaatc gtttcttaca tgttttatag tggttccaaa gctatgacga cagtttatag
     2641 agttaatagt aaacctttga aacccgaaca taattattct tttgaatttg gacaagatgt
     2701 aaatgaagcg aagcctgaaa aagctaatac atttggctta gaggttggtt atgggtttgg
     2761 cactaaatat caaaaaggtg atgtgtcgag ctataaagcg attactcctg agcatttagg
     2821 attaaaagat gtaaaagtaa tagaaaatgg gaaggagtct gatgatttaa gtattaaagt
     2881 tagagctaat gaaaagaaaa aaataacctt taaatcggaa aaatctgata cgccatcact
     2941 ccttgtatat actagaacaa aaggtgcaaa tactagacaa gattacatta attttagaga
     3001 ttttcaattt tacgatgtta cagaaccaga tatgtacaag tctaattcag gtgtagcaca
     3061 tgctggtcat gataaagtta ctttagaatt ggatacactt aaagggagag atgctctgat
     3121 agatcaaacg gtaactgtat acaatggtaa cgaaacactt ggtaccaaag ccattattct
     3181 gaattcaaaa gataagaaat taactataga tgctaaaagt ttaaaaaaag ctaaaacagg
     3241 tgatgtaatt aaggtaaaaa ttttacagtc tgattcaaaa aaatatagag aaacgacttt
     3301 caaagttact tttgatccta aagatgtaca agaacagaaa aaattattga cagatacaaa
     3361 agcaacagca tttaaaatca ataatatgaa tccttggtta agtaattcag agaaaagtct
     3421 agccaatact aaagttaatg aaacatttgc tcaagagttt aaaaaactag aagaggcttt
     3481 gaactctgaa ggattgacgc tggattcctt aaaagaaaaa gctagtgttt ctgttgggaa
     3541 aatcaattct ccagaacagc tagaagttac taaagctaga aaaataaaag aagcagaagc
     3601 tgcaataaat gctaaatatg ataaagtaaa ccagcagttg agtgaagaca agactattaa
     3661 agcttctgaa aaacctgaat tcgagaaaga gttagctaaa ctaaaagaag aagcattaaa
     3721 aggattatct ggagctacag atcttagaac tttaaatgaa agacagtata atggtgaaaa
     3781 gagtcttaca tatgaaactg gaaaacctat ttctgaacaa aagacagctg ctttggacga
     3841 attacaaaaa aaacatgtag aaactttaat gtctataaag gaagatactg gtttaagtaa
     3901 gtcggaaaaa gaaagtcaaa aagctgaagc aaataatgca tttgaagctg caaaggctag
     3961 aataaatagc aatgaagttg atgatgcaga taagttacag actgcaaaga ttgaggggca
     4021 aaatgctatt actaatgcat atgttaaagg agatttagaa aaatataaga aagctaaatt
     4081 gactgaactt gaagaggcaa ttacaaaaga acgtgaagtt ataactactg atgcttcttt
     4141 aacaactctt cagagaaagg ctaagcttaa agagttagaa gaagtagcgc agactgctaa
     4201 aaccgcaata aacgaaccag ataatgcaga tgacgtttta caagctttac aagttcatgt
     4261 accgaaggtt aaagctgttc acactccagg taagatagag gatgtgaaaa aaagtgctac
     4321 tgatagtctt aacaaaatcc ttaaagaaac actttctagt atagaaggtg ataaaagtct
     4381 tacgcaagca gaaaaagata aacaagttca agatgctcaa aaagtcttcg atgagagcaa
     4441 aaagaaaatt gaaaaagcaa ctgatgcgga caaagtttta gaatttaaaa ataaagctga
     4501 agaagctatt cctgaaacac atcaaaaagg taatcttgaa ggaattcaga cagctcaaaa
     4561 agctgagctc aagaaagttc atgacgaaac tgttgcagaa atcgaaaaag ataatggttt
     4621 gacgaagact gaaaaaaacg ctcaaaaaac taaagccgca gaagctttga agaaaggtga
     4681 agaagcagtt caatctgcaa cgacagcaga tgaagctatc gcgaaagctg aagagaataa
     4741 aaaaataatc actgttactc atgaaaaagg tgacttagca aaagttaaag ataaagcaaa
     4801 agaaggttta acagcaactt ataacaaaac cgttaaaaat atcaaagcag attcaggttt
     4861 aacagcagac gagcagaaga aacagttaga aggcactgaa aaagcttaca aggctggcga
     4921 acaagcaatc actactgctg aaaacgcgga caaagttggt gaagtgttac cggtcgagaa
     4981 aaagaaagtt tctgatgaat ataaagcggg tgacttgcca aaagttaagc aagcacaaaa
     5041 agacgcttta caaaaagttc atgacgaaac aattgcacaa gtcgaaaaag ataaaggttt
     5101 gacaacagag caaaaagacg ctcaaaaagc caaagcggca gaagctttga agaaaggtca
     5161 agatgcggtg gaagctgctc cgaaagcaga tgaagctatt aaagctggta ctgataatca
     5221 gcaacctatc aaagattcat atattcctgg caaactagac gatgttcaaa cgaaagcaac
     5281 agctgatctt aaaaaagctc atactgaaac agttgctaag ataaatggtg atgataccct
     5341 tgacaaagct actaaagaag ctcaagtgaa agaagctgac aaagctttgg cagcaggtaa
     5401 agaagctatc actaaagcag atgatgctga taaagtaagt acagctgtta cagagcacac
     5461 accaaaaatt aaagcagcac ataaaactgg tgatcttaaa aaagctcaag aagaggctaa
     5521 cacagctctt gacaaagcag ctgaaaaaga acgtgaagaa atcaataatg atatcacatt
     5581 aacggcaaaa gacaaagaac aacaactgaa agaagttgag acagctctta ctaaagctaa
     5641 agataacgtg aaagctgcta agacagcaga cgctatcaat gacgcacgtg ataaaggcgt
     5701 agcaacaatt gatgccgtcc ataaagcagg tcaagactta ggtgctcgta agtcaggtca
     5761 agtcgctaaa cttgaagaag cagctaaaga aacgaaagac aagatttcag ctgatccaac
     5821 tttgacaagc aaagaaaaag aagagcaatc taaagctgtt gacgctgaac ttaagaaagc
     5881 gatagaagct gttaacgcag ctgacacagc tgacaaggtt gacgatgctc ttggtaaagg
     5941 tgtcacagac atcaagaacc aacataagac aggtgaccct gtcgtagctc gtcgtgaggc
     6001 tcatggtaag caacttgata gagtcgctca agaaactaaa gatgcgattg aaaaagaccc
     6061 tactttgacg actgaagaaa aagctaaaca agttaaagac gtagatgccg ctaaagaaag
     6121 aggcatggct aagcttaatg aagctaaaga tgctgatgct ttagacaaag cgtacggtga
     6181 cggtgtgacc agcatcaaga accaacacaa gtcaggtgac cctgtcgaag ctcgtcgtgg
     6241 attacacaac aagtcaatcn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     6301 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     6361 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     6421 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     6481 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     6541 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     6601 nnnnnnnnnn nnnnnnnnnn nnnnnncttt gactgaagct gaaaaagaaa cacaacgtgg
     6661 caatgttgat aaagaagcaa ctaaagctaa agaagaactt gctaaggcta aagatgctga
     6721 tgctttagac aaagcgtacg gtgacggtgt aaccagcatc aagaaccaac acaagtcagg
     6781 taaaggtctt gacgttcgta aagatgagca caagaaagct cttgaagctg ttgctaaacg
     6841 tgtcactgct gaaattgagg ctgatccaac cttaacacca gaagtgagag aacaacaaaa
     6901 agcagaggtt caaaaagagc ttgaacttgc gactgataag attgctgaag ctaaagatgc
     6961 agatgaagca gacaaagctt acggtgacgg tgtcacagcg atcgaaaatg cccacgttat
     7021 tggtaaaggt atcgaagctc gtaaagacct tgctaagaaa gaccttgctg aagctgctgc
     7081 taagacaaaa gctctcatta ttgaagacaa aacgcttact gatgatcaac gtaaagaaca
     7141 gttattaggt gttgatacag agtatgctaa aggtatcgag aatattgatg cagctaagga
     7201 tgctgcaggt gttgataaag catatagtga cggtgttcgt gacatcctgg cacagtacaa
     7261 agaaggtcaa aaccttaatg atcgtcgtaa tgctgccaaa gaatttcttc ttaaagaagc
     7321 agacaaagtg acgaaactaa tcaatgatga tccaaccttg actcatgacc aaaaagttga
     7381 tcaaatcaac aaagttgaac aagctaagtt agacgcaatc aagtctgttg atgacgctca
     7441 aacagctgat gctatcaatg atgctcttgg taagggtatt gaaaacatca acaaccaata
     7501 ccaacatggc gatggcgttg atgttcgtaa agcgactgcc aaaggcgatc ttgaaaaaga
     7561 agctgctaaa gtgaaagctc ttattgctaa ggatccaacc ttgactcaag ctgataaaga
     7621 caaacaaaca gcagcggttg acgcagctaa gaacacagca attgcagcgg ttgataaagc
     7681 gacaacagca gatggtgtta accaagaact tggtaaaggc atcacagcta tcaacaaagc
     7741 ttaccgtcca ggtgaagctg ttaaagcacg taaagaagcc gctaaagctg atcttgaaaa
     7801 agaagctgct aaagtgaaag ctcttattgc taaggatcca accttgactc aagctgataa
     7861 agacaaacaa acagcagcgg ttgacgcagc taagaacaca gcaattgcag cggttgataa
     7921 agcgacaaca gctgaaggca ttaaccaaga acttggtaaa ggcatcacag ctatcaacaa
     7981 agcttaccgt ccaggtgaag gtgttaaagc acgtaaagaa gctgctaaag ctgatcttga
     8041 aaaagaagct gctaaagtga aagctcttat tactaacgac ccaaccttaa caaaagctga
     8101 taaagctaaa caaacagaag ctgttgctaa agctcttaaa gctgctatcg cagcggttga
     8161 taaagcgaca acagctgaag gcattaacca agaacttggt aaaggcatca cagctatcaa
     8221 caaagcttac cgtccaggtg aaggtgttaa agcacgtaaa gaagctgcta aagctgatct
     8281 tgaaaaagaa gctgctaaag tgaaagctct tattactaac gacccaacct taacaaaagc
     8341 tgataaagct aaacaaacag aagctgttgc taaagctctt aaagctgcta tcgcagcggt
     8401 tgataaagcg acaacagctg aaggcattaa ccaagaactt ggtaaaggca tcacagctat
     8461 caacaaagct taccgtccag gtgaaggtgt taaagcacgt aaagaagctg ctaaagctga
     8521 tcttgaaaaa gtagctaaag aaactaaagc tcttatttca ggagaccgtt acttgagcga
     8581 aactgaaaaa gcagcccaaa aacaagctgt tgagcaagct cttgcgaaag cacttggtca
     8641 agttgaggct gctaagacag ttgaagctgt taagttggca gaaaaccttg gtactgtagc
     8701 tatccgttca gcatatgttg ctggtttagc taaagatact gatcaagcaa cagctgctct
     8761 taacgaagcg aaacaagctg ctattgaagc tcttaaacaa gctgcggcag aaacacttgc
     8821 taagattaca actgatgcta aattgactga agctcaaaaa gctgaacaat cagaaaatgt
     8881 atcattagcg cttaagacgg ctattgcgac tgttcgttca gcacaatcta ttgcgtctgt
     8941 gaaagaagca aaagataaag gtattactgc tatccgtgca gcctatgtgc ctaataaggc
     9001 agtcgcaaaa tcatcgtcag cgaaccatct tccaaaatca ggtgatgcaa actcaattgt
     9061 tcttgttggc ttaggagtta tgtctcttct tttaggtatg gtgctttata gcaagaaaaa
     9121 agaaagtaaa gactaagaac ctggctttat ccaaattgct ttctactata ttttcaaacc
     9181 aaggtgattt tgaaatcacc ttggtttttt ggatcgtaag ggaccaagaa cggagtgtat
     9241 tgaaaacatt tcaaagttca attgaaaagg caacagtttt ctgtacagaa tttataaggc
     9301 gttttttgtt caaacgatga ctcatttagt tatgggtgtt tgataattaa gattactgtg
     9361 aaggtgatgg tagttccacc agtggacttc ctccttggtt ttaagggtta attgttctag
     9421 tgaataaaag gtttcttggt cgcgcagtag ggatcaagcg agtagataaa atgcctattt
     9481 taaatcagtt cgagcgaatt ttcgtgctac aagctcaaaa gaggctacta aagtattaga
     9541 atagtttatc tctgagtgaa gttcttgtta taagaagatg atgttatcgt ttgaaacgac
     9601 caaaaaatct cctaactttt actaatttct acatgaaatc tagtccagca tttactctac
     9661 aaccttgatt gattcgctta ataaagacat ttctacttga ttgtttacac atagttattg
     9721 atagaatcta ttataaaatt cagtatatta gatcataatt gtttctatat taatcaatta
     9781 ttactttttt tgtcattttt gataatatta aaaagaaagg gtttacatat taatcatttt
     9841 ttactataat aaaagtgata agaactagat agttgttgtg ttacaacagt acaattgagc
     9901 tagccttgtc cttgttgtgt taactttatt tttaaaataa ggttaaaaat aaacgactcg
     9961 tgttcttatc agttacttat tagataagga ggtaaacctt atgttaaaat ttacttcaaa
    10021 tattttagct actagtgtag ctgaaacaac tcaagttgct cctggaggct gctgttgctg
    10081 ctgtactact tgttgcttct caattgctac tggaagtggt aattctcaag gtggtagcgg
    10141 aagttatacg ccaggtaaat aatctattta gcatctctat gtgatagtga tattaaggta
    10201 atgagtttgc tagcaactaa gttatctttg gtaacttctg attatagatg aatggcatag
    10261 agatgttaga aaacatgaga caaaagtaat cttcttgatg ctaacgtctc aggtaattag
    10321 caggtactag acagtacctg ctaattacta tatgtttagt aaaatgagat aggaaagata
    10381 gttatgtcat tttttacaaa ggaacaacaa cctaaagaga attgtccgcc aataactgtt
    10441 gaaaaagcaa ggcaattgtt tgaatttaat acaaaccact tgtccttatc ggattaccat
    10501 catcaaacgg tgctaaaaac gtcaaagcag ctagttgctc aacatttaat gcctaatgca
    10561 accgataatc ttagtcaaca ttttttgatg aactataaag ctaataataa ttatttaggc
    10621 ttccaagcta gtattgtcga cttttttaca gattctgccg ttgctaattt ttcaagtagt
    10681 tacgtttatg aaagtcagga aaagataatt cgtttaccaa aacctaccaa gatatcaact
    10741 gctctgtcga catgtattat aaaacgaaga agtcatcgtc aattttcaga tagacaaatg
    10801 cctcttcaag atttatcaaa cattctttat tatgcatgtg gtgttagttc acaagcatca
    10861 attagagatg gagcatcaga taagattaca ctcagaaact gtgcttcagg tggaggttta
    10921 taccctattc atttagtttt ttatgctaga aacatcagta aattaataga tggtttctat
    10981 gaatatctac cctatcagca tgcactaagg tgttatcggc atagctctga ggaaaacgtt
    11041 agagattttg cggaatacgg tgctattaat gctgaaaatt gtaatattat tattatttat
    11101 gtctaccatt acatgaaaaa tacacgtaaa tatgggaatc aggcgactgc ctatgctttt
    11161 attgaatcag gagaaatagc ccagaatatt caattgactg caactgcctt aacttatgga
    11221 agtattgata ttggtggtta taataaggaa tatctccaag aattattaga tttagatggg
    11281 ctaggagagc atgtgattca catgacactc gtaggaacta aggagtctca atgaaatatc
    11341 aacttaatag taatgttcgt gtcgtgacat ttcaagatac attttgtttt agaaaaggaa
    11401 tctgggactt taatgaagcc attctagatt tgacacaaga acctcaaaat ttaaagatag
    11461 tttatcaaga aatagtttca cagttggtta agggagtagc cattgatact gaaacttatg
    11521 aaaatgcttt agaacctgag acgttcgcta atttaatgga agtcatttca ggcttgtatt
    11581 acaatgatat gctgatgctt gaggatgact acaatcttga agaaaatgtc atgaaaattt
    11641 taatgggtaa tttccgtttt atggcgcaag caggtcatat ggtaagcaat gatcctgttt
    11701 tgtttatcag tgattcgact tatgttaatg aatctgctga gttgctagct gaacaactgc
    11761 atttacaatt gcaagtggct agcgatgact taaaaatgtt aattcagcag acagatgtta
    11821 gttcgcgttt agatgctttg gagcatcgcc gtaacatgaa ttgtttatca gaagccttgt
    11881 gcgattacca aagtattatt atttgtcaag aacgcttgaa tattatgatg ttgcgacact
    11941 tgaatgaagt tagcgtagct atgaaaaaac aattagtgat tggttttgta gatggaccat
    12001 tcttgcacac ttgtactttg aatcctcccc atagtgctga ctttgatagc ttagaaagaa
    12061 gagttttggc acgtttacaa gactcaactc tctatcaaca ttttgctaat caggttttac
    12121 cagcaacaca agatgtgagc caggcctatt taccattgtt aaatgtttta atgaatttag
    12181 tcgttagcga agctttcatt attgctcaaa caggtagttc taaatttgag ggacgtttat
    12241 taagcattta cttaccgacg cttgagattc aggtccaaga tattttgaaa atgtctaatt
    12301 cacagacaca aggagctttg gcaaaattaa agtatgagga tcagcagata tcaacacgtg
    12361 agattgttaa aaaactcctt gacgagtaac ctataaggag aatctattat gttatactat
    12421 tatccttctt ttaatcatat ttttgatgaa ttaaaaagtt taagtggcaa tcgaacaggt
    12481 atcttaaatc aatctcaagt tccagtttgc aaccatcctc acgatgttta cttaaaaagt
    12541 attactggcc aaatgccaga ttatcataaa caatttatag gtgagttgag tcaagttagt
    12601 tatcacatta ttggttacgg cagttactat gaagaagcac ttatcaagta tttaggagaa
    12661 agtattgaac gctatgctac tgtaattgcc ggagacttac tatcagatcg gattgtctat
    12721 gcttcttata atgagttaaa actgttacat aaagtgatgc ctttagaata cttgcaagtg
    12781 tttactcaag aacagatcgc attatcttgt gacttgcaaa tgatgatgtg cgataaaatg
    12841 gtaactgaga acgatgtatt gggctgggtt aaatgtccca tgttctttga ggacgcagag
    12901 atgtatgttc cagctcaaat gctttgtgtt gggtataaaa caaatgagac tgtaggagaa
    12961 agacggataa taccaggatt ttctacggga acagcttctc acaaaacgtt agaagcggct
    13021 atgtgtaaca gtttgattga atacatccag atcgattcaa tgatgcttag ctggtatact
    13081 aagaagcctt gccccaaaat tattgttgat gatcctgata ttgaagtgat tttagaagaa
    13141 gctagactgg gaaaagacag tctatacgac attattccta tcgatatgac tgtaggagaa
    13201 gataatcctc tttatacgtt tggaatcatt ctcaaaaata aatatgatga agggccttac
    13261 ctcttgtttg gagtgcaggc tgggttagat cctaaacatg ctttgctaag agggatcatg
    13321 gaagcttcag ctattagcta tagttactac tataatcttt tatatcaaaa agcttccctt
    13381 gcaaatattg aatgcgaaga acctttgttt ttagatttag atagtaatgt tttctattat
    13441 gcacatccca aggaccaaga ccataaatgg aaggcctttg aacctttgat ttcaggagaa
    13501 gttctgttaa gtgatttgga agatcattct ggtaaagata aaaaagaaga tttgaagact
    13561 ttattagctt atgctaagaa agtcagtcct aatgctgtct ttttagatat tacacctcct
    13621 gaagctctag aaaaaggctg gtacgtcacg cgagttctga tgccagaact tcttgaaatg
    13681 tgtataccag catttccttt tgctaatcat ccacgaatga gacagtttgg aggtgtaaca
    13741 aatgcctttg tccatccaat gccttaatct ttgttttttg ttggtaactt tttgtccttc
    13801 aattcctatg caagctattt ttggaaaaga agatagtggt tatgcattta atttaattgg
    13861 ttttctaaga gcaactctga tttatgacat tttggctttg gtaagtattt atgttttgtc
    13921 acctcaaata accttgtctc ttgaaagtat tgatagtaag acgttcttta tgggacttgt
    13981 attttgcgtc tttatagtac tgattgaact cgttttctta catggtttac gttgttggca
    14041 aaaaaagcaa tggcttcctg caactttctc gtttgtagga acgacaaatg attggtctaa
    14101 gattggctat cctttattac tagctttatt tgaagagacg atttatcgtt ttttgtggtt
    14161 taatatatta gcttttcaat ggcatttacc aacaattatt gttttaattg taactagttt
    14221 ttgctatgct ttaaatcact tattgatggg gaaatccatt ttttatgcta agttggtaac
    14281 aggcatcatt tatggtagta tttacatgct gactagtcaa ttgtggttgg ttgtgataat
    14341 gcatgtagga ggtaacttgc tagttgagtg tcttagccat cttcaaacaa aaaagaagaa
    14401 ggaggtgaca tgatgctatt ggttttgctg tcgtttttag gtctaactac tctttggttg
    14461 accagttatc gaagacggtg tttggctaga tggcatcttc aatggttaat ggccttatcc
    14521 tatcaagatt ttttagatgt cttactgagt ctgtttcaat ttgtcgttat tatacttgtt
    14581 ttgttctttt actcagctac tattaatcta ggagaggttc tgaccttttt gacacaaact
    14641 agctggcatt ggcagattct ttgttattta gtgttatatc ttatggccat catagagatg
    14701 acgcttttag ttttaattct tatctttgat gttttgctcc agaaagatag tcgattgctc
    14761 tttaaaaaaa taacttggct gccttttaga caagataaac cagtcttaag tatactttta
    14821 ctaggcatag ctattctagt agacagtctc ttttatttgg gcttgcttat attattagga
    14881 gaacagtcgc taacaagttt agcaacgctt attttaggtt atgggatagt caaggcttgt
    14941 cgctattcag gctggttaaa tgtactatta gctttttgtc ttttcactat agttggacta
    15001 tgggcagtta cggcaacttt attatatggt tggctagtag gtgcgatgat attaacggtg
    15061 acttatttga tgattagttg caaagagtat tagcaatatt aaaaaggagt gatatatgag
    15121 ttttgtacaa ttaacaaatg ttgtcaagtc ctacaaaaac ggcaagaaag ctgtcaatga
    15181 tgtttccttg tctattgaag caggtaatat ttatggtctg ttaggaccaa atggtgctgg
    15241 taagtctacc ttgattaatc ttatcttagg cttgatccct ttgagttccg gtaaaattac
    15301 tgttttaggg caatcccaaa agactattcg aaaaataagt tcgcagatag gttatgttcc
    15361 tcaagacatt gctgtttatc cagacctaac tgcttatgaa aatgtagaac tatttgggtc
    15421 actttatggc ttaaagggag ctcagcttaa aaaacaagtt ctaaaaagtt tagaatttgt
    15481 ggggctacac tcccaagcta agcagtttcc aagtcaattc tcaggaggaa tgaagagacg
    15541 gttaaatatc gcttgtgcgc tagttcattc acctaaatta atcatttttg acgaaccgac
    15601 tgtagggatt gatcctcaat cacgtaatca tattttagag tcgattcgtt tgctaaacaa
    15661 agaaggtgcc acagttattt atacgaccca ttatatggaa gaagtagagg ctctttgtga
    15721 ttatattttt attatggatc atggtcaagt tattgaagaa ggacctaaat ttgaactgga
    15781 aaaacgttac gttgcaaatc tagcaaacca gattattgta actctaacag attcacgtca
    15841 tttggaactg gcagataagc ctgattggtc tttgatagaa gatggagaaa aactcatgtt
    15901 gaagattgat aatagtgata tgacatcagt tgttcatcag ctcacacagg ccaatattac
    15961 ttttagcgag attagacata accatttgaa tttagaagaa attttcttac acttaacagg
    16021 taagaagtta cgagattaga ggttactatg gttttatttc atttaatcaa aaaagaaagt
    16081 ttacagattt ttagaaaccg aacagcctta ttgatgatgg tgatttttcc aattttgatg
    16141 atcgttattt taagttttgc ctttaaatca agttttaata ctgcgacaac agtccctaaa
    16201 ttgaccattc gttaccaatt agagggtgaa aaaacggatt accagaaaaa ttttcttgct
    16261 tttttaaaag ttttaaacca aaaacttcat ttagaggcta aacctagtaa ttctcttgaa
    16321 aaagatcgac aaagagtcag tgaaggagcc ttaacggctg ttttagaagt gaagaagaat
    16381 cagaccatta aggttattac taataatatt aatcagcaaa atgcagattt gatcaatatg
    16441 ctagtaaaaa attatgtaga taatgctaaa acttatgact cgatagcagc tctttatcct
    16501 caacaattaa atcatatcag aaagcgaagt gtggactatg ttaaggtcag ttcaatacag
    16561 acaagtaaag gaatgacatc agctgattat tatgctattt ccatgtttac catgattact
    16621 ttttatagta tgatgtctgc gatgaacctt gttttgtcag atcgtcaaca acggattaca
    16681 aatcgtattc acttaacagg agtttctcca agtcttttgg tctttggaaa attaataggt
    16741 gctatgttag caacaactgt tcaattgagt cttttataca tttttacaag gtttgtttta
    16801 cgagttaatt ggggcactaa tgagtggatg cttattggta taacagcctc cttagtctat
    16861 ctctctgtag ctgtaggtat cgggctaggc ataagcatta aaaatgaggc ttttttaacg
    16921 gttgcatcca atactattat tcctatattc gcctttttag gaggcagtta cgttccattg
    16981 acaacattac acagctctat tattaatcaa ttgtcgaata tatctcctat taaatgggtt
    17041 aatgatagtt tgttctatct tatttttggt ggtcaatata atccgattcc tgtaactttg
    17101 atcgttaata ttagtatcgg aacaattttt ataatattgg cattgatagg tatgagaaag
    17161 caggtgacga catgatttgt tttataaaaa ctctatttgt taagataaag cgcaaaaaaa
    17221 caagttatgt gacattcttt ttaatgccta ttttaacgac acttttggct ttatctttga
    17281 gtttttcaaa taataatcag gctaaaattg ggatattaga taaagataat agtcagatat
    17341 ctaaacaatt tattgctcaa ctaaagcaaa acaaaaagta cgacattttt accaaaatca
    17401 aaaaagagca tattgatcac taccttcaag ataaatctct agaagcggta ttgactattg
    17461 acaaaggatt ctcagataaa gtgttgcaag gaaaatctca aaaactcaat atacgttcga
    17521 ttgctaatag cgaaattaca gagtgggtaa aggcacagac caattatcta ttggaaaatt
    17581 ataatattat aggggatgtg gctctaggta acgaagatac ttttaataga attctccaaa
    17641 aaaaccaaca gttaaattac gatgttaagc aagtaacttt gacagaccga tcacgtagca
    17701 aagcagtatc ttccacaacg acaggatttt tgcttattct aatgttaggt agtacgagcg
    17761 tgatttacag tggtattttg gcagataaat ctagtcagtt ataccatcga ttaatgttat
    17821 cgaatttatc tcgttttcgc tatatgttga gttacgtctg tgtaggattt gttgctttta
    17881 cgattcaaat tgtcattatg ctgagtttgt taaaagtatt taatattagt ttttttgttc
    17941 cgacatcact tcttttgatt atttttttcc tttttagttt attagcgata ggctttggcc
    18001 tgctgattgg agctatcaca caaaattccc aacaaagtag ccagttagct aatcttattg
    18061 taatgccgac ttcaatgttg gctggctgtt tatggccatt gtctattacg ccttcttata
    18121 tgcaagcaat tggtaagtta ttaccacaaa attgggtttt atcagccata gctatttttc
    18181 aaagtggagg gaccttatct caggcttggc catacttgtt agctctaatg ggaacagcac
    18241 tagctttgat cagtttttca agtttattat taaaacctac caaactataa ttagtctttt
    18301 gttaaaaaat actttcctaa ttagctaact accaggtagc ccttttattg gcttatatgc
    18361 aataaaaggg ttgctttttg cttatatttt ctctagtgca cttatctttt gttaaaagcg
    18421 attgcgatgt tactgttgtt actgtgtttt ttagagagca tattatcaaa agcgacccct
    18481 ctataaagtt cgtttttatt gataaatggg ttgtcaaagt attttgaaaa acgttttcaa
    18541 taaacataaa aactaatgtt attaaaaaaa gttttgaaaa cgtatttatt ttatggaatg
    18601 tttttgttac aataagcatg tatcgaatgc tataaagctg tcttgttcgc tatcaggggt
    18661 gcttgtgatg ttatgtcaga tcaaacaagt ctttaattgg gtgacttaac agattaaaag
    18721 aaaagatcta atcgtgttac ttgatagtat aattaatgca aacagaaagt gtatcccaat
    18781 tcatagtctc aggtggaggt taatattcaa aaataaaatc ttgttgttgt cttaaactaa
    18841 tcacattaaa aggagatatc atgattaaca agaaatgtat aatatctgtt tcattgttga
    18901 cactagctat tacgcttact agtgttgaag aagttacttc acgccaaaat ttgacttatg
    18961 ccaatgaaat cgtaacacaa aggccaaaga gagaatctgt tattagtgat aaatcgaatt
    19021 ttcccgtcat atcaccttac ctagcaagtg tggattttgg tgagagaaaa acatctttgc
    19081 caacacctga taaaggagta aaagtaacta ctgaacagtc tattgctcaa gtaagaaagg
    19141 ggcctgaaga aagaacctat actgttactg gcaagattac gagtgtgatc aatggctggg
    19201 gaggctatgg cttttatatt caagatagtg aaggtattgg actttatgtt tatcctcaaa
    19261 aagatttagg atacagtaag ggagatattg ttcaattaac aggcacactt actcgcttta
    19321 aaggtgattt acaactccaa caggtgactg cacacaaaaa gttagagtta tcttttccga
    19381 cttctgttaa agaagcagta atatcagaat tagaaacaac aacaccctca acattagtta
    19441 agttatctca cgtgacagtt ggagaattat caactgatca atataacaac acatctttcc
    19501 ttgtaaggga tgatagtggt aaaagtatag ttgttcatat agatcatcgt acaggggtta
    19561 aaggggctga tgttgttact aaaataagtc agggtgattt gattaacctc acagccatat
    19621 tgtctattgt tgatggtcag ttacaattaa gaccgttttc tcttgaacaa ttggaagtgg
    19681 ttaaaaaggt cacaagctca aatagtgatg cttcatctcg taatattgtg aaaataggcg
    19741 agattcaagg agctagtcat acgtcgccac ttctcaaaaa agcggtcacc gtagaacagg
    19801 ttgttgtcac ttatttagac gattccactc atttttatgt tcaagatctt aatggtgatg
    19861 gtgatttagc gacttcagat ggtattcgtg tttttgctaa aaacgctaag gttcaagtcg
    19921 gcgatgtttt gaccatttca ggtgaagtgg aagaattctt tggtcgtggt tatgaggaac
    19981 gtaagcagac tgaccttacc atcacccaaa ttgtggctaa agcagtgacc aaaacaggga
    20041 cagctcaagt tccatcaccg cttgttttag ggaaagatcg tatcgcgcca gccaatatta
    20101 ttgataatga tggcttgcgt gtgtttgatc cagaagaaga cgctattgat tattgggaat
    20161 caatggaagg catgttagtg gcggttgatg atgctaaaat ccttggtcca atgaaaaata
    20221 aagaaattta tgtcttacct ggctctagta caagaccgtt aaataattca ggtggagtat
    20281 tacttccagc taattcttat aacacagatg tgattcctgt tcttttcaaa aaaggcaaac
    20341 aaattattaa agcaggagac tcttacaaag gaagattagc tgggccagtg tcttatagct
    20401 atggtaatta caaggtcttt gttgatgaca gcaaaaacat gccaagttta atggatggtc
    20461 atctaaaacc tgaaaaaaca aacttgcaaa aagaccttag caagttaagc attgcttctt
    20521 acaatattga aaacttctca gccaatcctt cttcaactaa agatgagaag gtcaaacgga
    20581 ttgccgaatc ttttattcat gatctgaatg ctccagacat tattggatta attgaagtcc
    20641 aagataataa tgggccgact gatgatggga caacggatgc gacacaaagc gcgcaacgcc
    20701 tcattgatgc tattaaaaaa ctaggtggcc cgacttatcg ttatgttgat attgctccag
    20761 aaaataatgt tgacggaggt caaccaggtg gtaatattcg aacaggattc ctttatcaac
    20821 cagagcgcgt cagcctttct gataagccaa aaggcggtgc tcgtgatgct ctaacttggg
    20881 ttaatggaga attaaacctt agtgttggtc gaattgatcc aactaacgcc gcttggaaag
    20941 atgttcgtaa atcactagca gcagaattta tcttccaagg tcgtaaagtc gttgttgttg
    21001 caaatcattt gaactctaag cgtggggata atgctcttta tggtcgtgtg caaccagtca
    21061 cttttaaatc tgagcaaaga cgtcacgtct tggctaatat gctagcacaa tttgcgaaag
    21121 aaggggcaaa acaccaagct aatattgtga tgctaggtga ctttaatgat tttgaattca
    21181 caaagacgat tcaattaatc gaagaaggtg atatggttaa cttggtgagc cgacatgata
    21241 tttcagatcg gtattcttat tttcaccaag gcaataatca gacccttgat aatatattag
    21301 tttcacgcca tttacttgat cactacgaat ttgacatggt tcatgtgaat tccccattta
    21361 tggaagctca cggacgcgca tcagatcatg atccattgtt acttcaatta tcattttcta
    21421 aagaaaatga taaggcagag tcttctaaac aaagtgtaaa agctaaaaaa acttcaaaag
    21481 gaaaactgtt gccaaaaaca ggagatagtc ttgtttatgt gataacgcta ctaggaacgg
    21541 ctagtttatt agtgcctatt ttattattga ctaaaggcaa aaaggaatca tagcgatttg
    21601 aagaattgca gttcataaag agtcgttaaa ggcttgatat acttacgtta gaccttaagc
    21661 taaaatggat gactatataa aaactaatat tgataacaaa agaagataac aataagacag
    21721 ctttacttgc taaagacttt tgtcaagcta attgttttat ggtacaatgt aaccgttgct
    21781 ttgcaaccct tggtgcttag ttccctttca ccaagcatat tagaaacgta gatagctttt
    21841 gagagttatc tagacgttaa aggagaaaaa atgacaaaat tgactgtaca cgactatgtt
    21901 cacattgggt tagtagctgc cttgtatgtt gtcttaacta ttaccccacc tttgaatgcg
    21961 atttcttatg ggatgtatca atttagaata tctgaaatga tgaatttctt agctttttat
    22021 catcgcaagt atattattgc ggtgactctt ggatgtatga ttgctaactt ttatagtttc
    22081 ggactgattg atgtctttgt aggcggcggt tcaactctta tttttgtgac cttaggtgtt
    22141 attttgttta gtaagtatca aaaagattat ctttttaatg gtatttttaa taaagctttt
    22201 gtttactttt ctttcttttt tgcaacttcc atgtttactg tagcaatcga actttacttc
    22261 tttggagctc catttttatt aacatggttt acaactgcgt taggagaatt agtatctctg
    22321 ctcataggat cacttattat tgataagttg tctcaaagaa tttcctttta gtaatgcatc
    22381 atactcaaaa gagttgggtc aatacccttc tcttttttat gttgtttgta atgttaaaat
    22441 cgttctagat agaaatattt aacactttag ctaatagtac catatggagt ggccaacgat
    22501 tacttttgat gttgttatga tatagaaaat agctcatttg ttatctttta tgataaaata
    22561 aaagtatgaa aaaacgcata aaagaattaa cagatcttct taaccgttac cgttatgact
    22621 attatactaa agatgcccca tcagtttctg acagtgacta tgataagctt tatcgtgaac
    22681 tggtgacttt agagcagtca tatcccgagt atgtcttgca agatagccca acgcagcagg
    22741 ttggagggac tattttaaag gggtttgaaa aatatcgaca tcagtatccg ctttttagtt
    22801 tgcaggatgc tttttcacgt gaggagctgg atgcttttga taagcgcgtc aaggccgaat
    22861 ttccgaatgc cacctatcta gcagagttaa aaattgatgg tttatctatt tccttgagtt
    22921 atgagaatgg cttcttacag gttggagcaa cacggggtga tggcaatatc ggtgaaaata
    22981 tcacagaaaa tatcaaaaaa ataaaggata ttcctcacca attgagtgag cctttaacca
    23041 tcaccgttcg aggagaggct tacatgtctc gtcagtcctt taaagcgatc aatgaagcac
    23101 gccaagaaaa tggggagact gaatttgcta atcctagaaa tgctgccgct gggacactaa
    23161 gacagctaga tacgtcagtg gttgctaagc gtcaactagc cacttttttg tatcaagaag
    23221 ctagtccgac agctagaaat caacaaaatg aggtcttagc agaattagca gatctaggtt
    23281 tttcagtaaa tccgtattat caactcacat cgtctatgga tgagatttgg gattttatca
    23341 aaactattga ggcaaaaaga gatcaattag cttatgacat agatggcgtt gttattaaag
    23401 ttaatagcct agccatgcaa gaagagctag ggtttacggt taaagctcca cgctgggcca
    23461 ttgcttacaa atttccagca gaagaaaaag aggcagaaat cctttcggtt gactggacag
    23521 tgggacgaac aggcgtggtc acacctacag cgaatctaac tcctgtgcaa ctagcgggga
    23581 caaccgtgag tcgtgcaacc ctacataatg tggattatat tgccgaaaaa gatatccgta
    23641 ttggcgatac agtgattgta tataaggcag gggacattat tcctgctgtc ttaaatgtcg
    23701 ttatgagtaa gcggaaccag caagaagtca tgcttattcc taaactatgc ccatcttgtg
    23761 gtagtga
//
