LOCUS       NZ_CAAHKQ010000003     11864 bp    DNA     linear   CON 11-MAY-2024
DEFINITION  Streptococcus pyogenes strain A904, whole genome shotgun sequence.
ACCESSION   NZ_CAAHKQ010000003
VERSION     NZ_CAAHKQ010000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (03-APR-2019) WTSI, Pathogen Informatics, Wellcome Trust
            Sanger Institute, CB10 1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900983695.1-RS_2024_05_11
            Annotation Date                   :: 05/11/2024 02:54:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,776
            CDSs (total)                      :: 1,717
            Genes (coding)                    :: 1,662
            CDSs (with protein)               :: 1,662
            Genes (RNA)                       :: 59
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 50
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 55
            CDSs (without protein)            :: 55
            Pseudo Genes (ambiguous residues) :: 0 of 55
            Pseudo Genes (frameshifted)       :: 29 of 55
            Pseudo Genes (incomplete)         :: 29 of 55
            Pseudo Genes (internal stop)      :: 25 of 55
            Pseudo Genes (multiple problems)  :: 23 of 55
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 15:26:47
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 135510
            Orig. end                         :: 147374
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CAAHKQ010000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11864
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11864
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11864
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5000:6864](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6864)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            23..286
                     /locus_tag="E9664_RS09215"
                     /old_locus_tag="SAMEA3919112_00500"
     CDS             23..286
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="E9664_RS09215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMEA3919112_00500"
                     /product="hypothetical protein"
                     /protein_id="WP_168389318.1"
                     /transl_table=11
                     /translation="MDNLSLKNNPLWGNPYIQFVTGKLINIKKSVSDLAAALLLSAFAA
                     IDSKVKADETAGAYRYDVSEQNTYYQTISSINQQRPGATLDE"
     gene            180..422
                     /locus_tag="E9664_RS09490"
     CDS             180..422
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285423.1"
                     /locus_tag="E9664_RS09490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_002985713.1"
                     /transl_table=11
                     /translation="MKQQGHTVMMCLNKTLTIKLSAPLTSNDLVPLSTNEVIIMEPLLH
                     LLPKVVPVLIHLVDKANVSWLTVILQLPILLKTIW"
     gene            944..1213
                     /gene="stcA"
                     /locus_tag="E9664_RS02505"
                     /old_locus_tag="SAMEA3919112_00501"
     CDS             944..1213
                     /codon_start=1
                     /gene="stcA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560518.1"
                     /locus_tag="E9664_RS02505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_00501"
                     /product="quorum-sensing system protein StcA"
                     /protein_id="WP_053308562.1"
                     /transl_table=11
                     /translation="MTKKQFYLILAISILCFILAVSPKPPIPKHTIERKRTAMTIGHSK
                     QTPHKKEALKHKKNKNKALFLPSGDSAIKSVISMTVRLLLDDQS"
     gene            complement(1561..1959)
                     /locus_tag="E9664_RS02510"
                     /old_locus_tag="SAMEA3919112_00502"
     CDS             complement(1561..1959)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635342.1"
                     /locus_tag="E9664_RS02510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_00502"
                     /product="hypothetical protein"
                     /protein_id="WP_032464238.1"
                     /transl_table=11
                     /translation="MHRLPNRLIPEEDNNKLSRVAKEVVTEPRLNNPFLLPKKVLSLED
                     DAAILNHLEEDRNVNKLFLEPVAAEAKREINFHPSDQQVTAKVKESSDFHQKQHQTGIT
                     YGDDTLADLAHHLLHSDGVIPSLNDKSA"
     gene            complement(2052..3122)
                     /locus_tag="E9664_RS02515"
                     /old_locus_tag="SAMEA3919112_00503"
     CDS             complement(2052..3122)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528351.1"
                     /locus_tag="E9664_RS02515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_00503"
                     /product="hypothetical protein"
                     /protein_id="WP_136048046.1"
                     /transl_table=11
                     /translation="MMMLRDVKVKTSSLLVGCAATLLVSLSGTVAADSVHSSDRRFGVG
                     YKEETTSQFSSDQPSQVVLYRGEANTVRFTYTNQMSLMKDIRIALDGSDKSLTAQIVPG
                     MGHVYEGFQTSARGIFTMSGVPESTVPVANPNVQTKYTRYFKVIDDMHNTMYKGTVFLV
                     QPQAWKYTMKSVDQLPVDDLNHIGVAGIERMTTLIKNAGALLTTGGSGAFPDNIKVSIN
                     PKGRQATITYGDGSTDIIPPAVLWEKGSVKEPTEADQSVGTPTPGIPGKFKRDQSLNEH
                     EAMVNVEPLSHVVKDNIKVIDEKSTGRFEPFRPNEDEKEKPASDVKVRPAEVGSWLEPA
                     TALPSVEMSAEDRLKS"
     gene            complement(3373..3774)
                     /locus_tag="E9664_RS02520"
                     /old_locus_tag="SAMEA3919112_00504"
     CDS             complement(3373..3774)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017771275.1"
                     /locus_tag="E9664_RS02520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_00504"
                     /product="hypothetical protein"
                     /protein_id="WP_023605036.1"
                     /transl_table=11
                     /translation="MRNILRFLGIVIISAVILFSIGSFYDLPLMKNIQLICWSFILDLF
                     VFVYKQRQTTEVLTWYQVVKQFWLFIKCTILIPTLIAFIIIIGCLTSISEVSIYFYLHL
                     IVVCYTIGMILSLGRLISPNHSIFNKLKK"
     gene            complement(3968..4249)
                     /locus_tag="E9664_RS02525"
                     /old_locus_tag="SAMEA3919112_00505"
     CDS             complement(3968..4249)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528350.1"
                     /locus_tag="E9664_RS02525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_00505"
                     /product="hypothetical protein"
                     /protein_id="WP_011054252.1"
                     /transl_table=11
                     /translation="MKILDIIFNLSDRKMIFLENVEKLGGYIVPFTLIILSVAYNFRHP
                     YPIWAAVLGGISLIVIFIYFILIVYLYLRYRYLVWKKIPEIKINSTEL"
     gene            complement(4299..4472)
                     /locus_tag="E9664_RS09460"
     CDS             complement(4299..4472)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003073350.1"
                     /locus_tag="E9664_RS09460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bacteriocin"
                     /protein_id="WP_306460903.1"
                     /transl_table=11
                     /translation="MAIINGGGKDGANIFLTGMAGAAQGVTVCAQTGVFIPWQGYILCG
                     AAGAATNIIWPH"
     gene            complement(4788..4988)
                     /locus_tag="E9664_RS02540"
                     /old_locus_tag="SAMEA3919112_00506"
     CDS             complement(4788..4988)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010921972.1"
                     /locus_tag="E9664_RS02540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_00506"
                     /product="class IIb bacteriocin, lactobin A/cerein 7B
                     family"
                     /protein_id="WP_002985729.1"
                     /transl_table=11
                     /translation="MTTMKELTINDMASISGGNAPGDAVIGGLGGLASGLKFCKLPHPV
                     LAGGCVVGFTVGGAYLGYTAN"
     gene            complement(5001..5228)
                     /locus_tag="E9664_RS02545"
                     /old_locus_tag="SAMEA3919112_00507"
     CDS             complement(5001..5228)
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015016754.1"
                     /locus_tag="E9664_RS02545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_00507"
                     /product="Blp family class II bacteriocin"
                     /protein_id="WP_002992018.1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 6.9e-18,
                     bitscore: 58.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEIKKLETFHQMTIEKLAKVEGGKNNWQANVSGVIAAGSAGAAIG
                     FPVCGVACGYIGAKTAITLWAGVTGATGGF"
     gene            5546..6227
                     /locus_tag="E9664_RS02550"
                     /pseudo=""
     CDS             5546..6227
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000191693.1"
                     /locus_tag="E9664_RS02550"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTQFTTELLNFLAQKQDIVLSLLFRNSYE"
     gene            complement(6447..6629)
                     /locus_tag="E9664_RS02555"
                     /old_locus_tag="SAMEA3919112_00510"
     CDS             complement(6447..6629)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002987564.1"
                     /locus_tag="E9664_RS02555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_00510"
                     /product="class IIb bacteriocin, lactobin A/cerein 7B
                     family"
                     /protein_id="WP_002987564.1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 2.7e-08,
                     bitscore: 27.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNFLELQFEELVNISGGKGNIGSAIGGCLGGMLIAAAGGPITGG
                     AAAFVCVASGIAAYQ"
     gene            complement(6644..6864)
                     /locus_tag="E9664_RS02560"
                     /pseudo=""
     CDS             complement(6644..6864)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994504.1"
                     /locus_tag="E9664_RS02560"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="bacteriocin class II family protein"
                     /pseudo=""
                     /sec_met_domain="Bacteriocin_IIc (E-value: 7.7e-11,
                     bitscore: 35.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKFAEEIQKEELFHIIGGYSATDCKNHLIGGITSGAIAGGWLL"
     misc_feature    complement(6821..6835)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 20.12"
                     /tool="antismash"
     gene            7262..7516
                     /locus_tag="E9664_RS09340"
                     /old_locus_tag="SAMEA3919112_00512"
     CDS             7262..7516
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990779.1"
                     /locus_tag="E9664_RS09340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_00512"
                     /product="hypothetical protein"
                     /protein_id="WP_011106868.1"
                     /transl_table=11
                     /translation="MSGLFYHKSYFFKSEQVYDLLNEIRMRYPHAHIILIGNHINYEEI
                     FKNHYRVFGVIDTTSHKSLRSIRDQIQLYLDELYNSNNG"
     gene            complement(7822..8298)
                     /locus_tag="E9664_RS02570"
                     /old_locus_tag="SAMEA3919112_00513"
     CDS             complement(7822..8298)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880370.1"
                     /locus_tag="E9664_RS02570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_00513"
                     /product="NUDIX hydrolase"
                     /protein_id="WP_023078738.1"
                     /transl_table=11
                     /translation="MPQDYISYIRSKVGHDKIILNFAGGILTNDDGKVLMQLRGDKKTW
                     AIPGGTMELGESSLETCKREFLEETGIEVEAVRLLNVYTHFEEVYPNGDAVQTIVFIYE
                     LTAVSDMAIDNFHNEETLKLQFFSHEEIAELESVSAKHRLMLEEYFTDSFAMGH"
     misc_feature    8255..8271
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 21.42"
                     /tool="antismash"
     gene            complement(8318..9214)
                     /gene="era"
                     /locus_tag="E9664_RS02575"
                     /old_locus_tag="SAMEA3919112_00514"
     CDS             complement(8318..9214)
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /codon_start=1
                     /gene="era"
                     /gene_functions="other (smcogs) SMCOG1227: ribosome
                     biogenesis GTP-binding protein YsxC"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003047080.1"
                     /locus_tag="E9664_RS02575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_00514"
                     /product="GTPase Era"
                     /protein_id="WP_002985743.1"
                     /transl_table=11
                     /translation="MFKSGFVAILGRPNVGKSTFLNHVMGQKIAIMSDKAQTTRNKIMG
                     IYTTETEQIVFIDTPGIHKPKTALGDFMVESAYSTLREVETVLFMVPADEKRGKGDDMI
                     IERLKAAKIPVILVINKIDKVHPDQLLEQIDDFRSQMDFKEVVPISALEGNNVPTLIKL
                     LTDNLEEGFQYFPEDQITDHPERFLVSEMVREKVLHLTQQEVPHSVAVVVESMKRDEET
                     DKVHIRATIMVERDSQKGIIIGKQGAMLKKIGKMARRDIELMLGDKVYLETWVKVKKNW
                     RDKKLDLADFGYNEKEY"
     misc_feature    9267..9282
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.57"
                     /tool="antismash"
     gene            complement(9334..9741)
                     /locus_tag="E9664_RS02580"
                     /old_locus_tag="SAMEA3919112_00515"
     CDS             complement(9334..9741)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002262772.1"
                     /locus_tag="E9664_RS02580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_00515"
                     /product="diacylglycerol kinase"
                     /protein_id="WP_002985746.1"
                     /transl_table=11
                     /translation="MALHDNNTTKRKWKNRTITSSLEFALTGVFTAFKEERNLRSHLLS
                     ACLACVAGLFFSISAIEWLFLLLAIFLVITLEIVNSAIENVVDLASDYHFSMLAKNAKD
                     MAAGAVLMISGYAVLTGLIIFIPKIWNIFVH"
     gene            complement(9722..10219)
                     /gene="ybeY"
                     /locus_tag="E9664_RS02585"
                     /old_locus_tag="SAMEA3919112_00516"
     CDS             complement(9722..10219)
                     /GO_function="GO:0004540 - RNA nuclease activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0042254 - ribosome biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="ybeY"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018380869.1"
                     /locus_tag="E9664_RS02585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_00516"
                     /product="rRNA maturation RNase YbeY"
                     /protein_id="WP_002985748.1"
                     /transl_table=11
                     /translation="MYIEMIDETGQVSQEIMEQTLDLLNFAAQKTGKEEKEMSVTFVTN
                     ERSHELNLEYRDTDRPTDVISLEYKPETPILFSQEDLAADPSLAEMMAEFDAYIGELFI
                     SIDKAREQSQEYGHSFEREMGFLAVHGFLHINGYDHYTLEEEKEMFTLQEEILTAYGLT
                     RQ"
     misc_feature    complement(10233..10247)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 18.45"
                     /tool="antismash"
     gene            complement(10378..10953)
                     /locus_tag="E9664_RS02590"
                     /old_locus_tag="SAMEA3919112_00517"
     CDS             complement(10378..10953)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985750.1"
                     /locus_tag="E9664_RS02590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_00517"
                     /product="uracil-DNA glycosylase family protein"
                     /protein_id="WP_009880369.1"
                     /transl_table=11
                     /translation="MDDLTKAIMADEANLSYTERGIFPLYDAPQTARIIIVGQAPGIVA
                     QETKLYWNDRSGIRLRDWLGVDNDTFYHSGLFGIIPMDFYYPGKGKSGDLPPREGFAAK
                     WHPPLRALMPEVELTILVGRYAQDFYLGNKAYKTLTETVRHFEDYLPDYFPLVHPSPRN
                     QLWLAKNPWFEQDLLPILQKRVEAILTK"
ORIGIN
        1 atggatatcc tgattatcgt tggtggataa cctttcgctt aaaaacaatc cactttgggg
       61 aaacccttat attcagtttg taacaggaaa actaataaat attaaaaaga gtgttagcga
      121 cctagcggca gctttactct taagtgcgtt tgctgccatt gacagcaagg tcaaagctga
      181 tgaaacagca ggggcatacc gttatgatgt gtctgaacaa aacacttact atcaaactat
      241 cagctccatt aaccagcaac gacctggtgc cactctcgac gaatgaggtg attattatgg
      301 aacccttact tcatttactt cccaaagtcg taccagtact tatacacttg gtagacaaag
      361 ccaacgtatc atggttaaca gtgatattac agttacctat actcttaaag acaatttggt
      421 agcccttcat aaggaatata aaacctttgt caaaaaaata ttacagataa accgatcacc
      481 agtgactacg acaaggctaa ggttatttat aaccatttaa tcaacgaata cacttacgcc
      541 acaaaataac ttagcaccaa tcgcaaaacc gtaagcagca tcaacaatca tactcctaaa
      601 gctctttatc gtggcaagtg tggtgtttgt caagcttatg ccgtcatgtt taaagatatg
      661 gcagaagctg caggcttatc agcttggtat gtgataaaaa aggattgaat gagcaccatg
      721 cttgaaacat cgttaccatt catggtgtta attcctacgt tgatgctacc tggaatgatt
      781 cagcatacac cacaaggtat ttccttgctg gaaaagacgt gaggaatact gagtaccgtt
      841 tagatagcca gtacaaccac ttggcttatg ctattttaaa taccagctac caaaaaggct
      901 aaactaacaa caactacatt tttcaactag aaaggcctaa acaatgacca aaaaacagtt
      961 ttatcttatc ttagctatta gcatactgtg ttttattctt gccgtcagcc ctaaaccacc
     1021 aattcctaaa cacactattg aaaggaaaag gactgcgatg accataggcc actcaaaaca
     1081 aacccctcac aaaaaagaag cccttaaaca caaaaaaaac aaaaataagg ctctatttct
     1141 tccaagtggg gacagcgcta tcaaatctgt tattagcatg acagttagac tcctgttaga
     1201 tgaccaatct tagctctcct aaaatcagtg gacactacca tttcggtagt gttctttttt
     1261 aagctaatct catcaccacg ctttcttcaa gctaaaaaac tgatcatgaa agagcaaccc
     1321 catcacccta acagcccact ttgcccgcac tttcttaaaa agttaggaga aaacgatata
     1381 ccaattattt tctgatccca gctccctatc attaacaaga tgtgtagcac ggacctacat
     1441 acaggtaagc tagagtcatt ctcgctattt cggacaaaaa gaggccggta gttccctgac
     1501 ctcttcttta tttatcttgt aacactcctc ttcttagcga gacttactag cacataattc
     1561 ttaagcactc ttatcattta gactaggaat aacaccatct gaatgaagca aatgatgcgc
     1621 cagatctgcc agagtatcat ctccataagt aatccctgtt tggtgctgtt tctgatgaaa
     1681 atcagatgac tccttaactt tagcagtcac ctgctggtca cttggatgaa aattaatttc
     1741 tctcttggct tcagccgcaa ctggctcgag gaacaactta ttgacattac ggtcttcctc
     1801 caaatgatta aggatagcag catcatcttc taacgaaaga accttcttgg gtaacaaaaa
     1861 ggggttattt agccttggct cagtaacgac ttccttggct actcgtgata gtttattatt
     1921 gtcttcctca ggtatcaaac ggttaggcaa tcgatgcaat tcttccggct gtgaggcgct
     1981 cacagctact tcagaagaaa cctccaagcc ctttcctgtt tgcctgtcta aagcaaccgg
     2041 caaattatta actaactttt taacctgtcc tcagcgctca tttcaacact aggaagagct
     2101 gtcgctggtt ctagccagct accaacttct gctggtctta ccttaacatc gctggcaggc
     2161 ttctccttct catcttcatt aggtctaaaa ggctcaaacc gccctgttga tttttcatct
     2221 atgaccttta tattgtcttt tactacatga gacagtggtt cgacatttac catagcttca
     2281 tgctcgttaa ggctctggtc tcgtttgaat ttaccaggaa taccaggagt cggtgttccg
     2341 acagattgat cggcttcagt aggctctttt acggagcctt tttcccataa aactgctgga
     2401 ggaataatat ccgtagagcc gtccccataa gtaatcgtgg cctgcctccc ctttggatta
     2461 atagatactt taatattgtc tgggaaagcc ccactacctc ctgtggttaa aagggcaccc
     2521 gcatttttaa tgagagttgt cattcgttca ataccagcaa cgccaatatg gttcaagtca
     2581 tctactggta actgatcaac agatttcatg gtgtatttcc aagcttgcgg ttgaacaaga
     2641 aaaacagttc ctttatacat tgtgttatgc atatcatcaa tgactttgaa ataccttgta
     2701 tatttggttt gtacattagg gttagcaacg ggaacagtgc tttcaggaac tcctgacatc
     2761 gtaaaaatcc ctctagcaga agtttgaaag ccctcataaa catgacccat accaggaaca
     2821 atctgagcgg tcaaagactt atcagaacca tccaaagcaa tgcgaatatc tttcatcaga
     2881 gacatctgat tggtataggt aaacctaacc gtgttagcct cacctcgata caaaaccact
     2941 tgggagggct gatccgaaga aaactgagag gttgtttctt ccttatagcc aactccaaaa
     3001 cgtctatcag acgaatggac tgaatctgcc gcaactgtac cactcaaact gactagtaaa
     3061 gtagccgcac aaccaactaa taaactgctc gttttaactt taacatctct taacatcatc
     3121 atgttccttt cattattttt tatttaggaa ttcgtcatac tatattttct catattagtc
     3181 taacaaaaaa ctcgtaattc tatataaatc atataaaatg acgagttttg gcaaagatga
     3241 gtatagcagg atagaagaca gattatttct gaaacttcaa aggtatcttc ttgtcacgaa
     3301 ctattcttta attgaatcgg ttacactaaa ctagtcccat tatttaaaaa caaactttaa
     3361 atatgattca cttcactttt taagtttatt aaatatagag tgattaggag aaataagacg
     3421 acctaatgat aaaatcattc ctattgtata gcaaacaaca ataaggtgta aataaaagta
     3481 aattgatacc tctgatatac tcgtcaaaca tcctattatt ataataaaag caattaaggt
     3541 aggaataaga atagtacact taataaataa ccaaaattgc ttaacaactt gataccatgt
     3601 gagcacttct gtcgtttgtc tttgtttgta gacaaaaacg aataaatcaa ggataaaact
     3661 ccaacagata agttgtatat ttttcattaa tggtaaatcg tagaaactac ctatactaaa
     3721 tagaatcact gcagaaataa taacaatacc taaaaatctt aatatattac gcatatcttc
     3781 acctcctcta ctctatcggt agcaaatata accgaacaaa ttgttattcc tgttatcaga
     3841 gacagttata acttttttaa ccaattttca atacgcattt tgcttttaac tctttagtct
     3901 ctaaagttaa atatcatacg tactgatatt gtataagtca tccattttcc ccttaaatgt
     3961 gattgtatta taactcagta gaattaatct taatttctgg tatttttttc cataccaagt
     4021 atctataacg caaatataga taaacaataa gtataaaata aataaagatc acaataaggg
     4081 atatacctcc tagtacagca gcccaaatag gataagggtg cctaaagttg taggctacac
     4141 tcaagatgat aagggtaaaa gggacaatgt aacctcccag cttttcaaca ttttctagaa
     4201 atatcatctt tctatcagat aggttaaaaa taatatctaa aattttcata ccactcctct
     4261 actacttata catcagtgat agatagtcat ttatatattt agtgaggcca gataatattt
     4321 gtagcagcac cagctgctcc acacaaaata taaccttgcc aagggataaa tacgcctgtc
     4381 tgagcacaaa ctgtcactcc ctgcgcagca cctgccatcc ctgtcaaaaa gatatttgct
     4441 ccgtcttttc cgcctccatt tatgatagcc agaccatttt tttagcactt ccatattttt
     4501 gaagtctttt tcattttaat ttcactcttt tgtattttaa aaagctaaga gtgatatcta
     4561 aattcattgg cataatcact attttctttt atcgataaaa acaaataatg acgctaccaa
     4621 agctacgata gataacatgt ttaccgattt ttctgaaagg gataattgat tgaaaattaa
     4681 aaacactaaa tatggtatag atttatcaac atttttttat gaatggcatc aacaatgatt
     4741 aaaaacatta tagacgcatt cataataata aaaatcgtat agatcattta atttgctgta
     4801 tatcccaaat atgctccacc aactgtaaat cctacaacac atccacctgc caatactgga
     4861 tgtggcagtt tacaaaattt caatccagaa gctaagcctc caagaccacc aattacagca
     4921 tctcctggag cgtttcctcc acttatacta gccatgtcat taattgttaa ttccttcatt
     4981 gttgtcatcc tttctttcct ctagaatccg cctgtagctc ctgttacacc agcccaaaga
     5041 gtaatagctg ttttagctcc aatataacca caggctacac cgcaaactgg aaaacctata
     5101 gcagctccag cactacctgc agcgataacc ccactgacat ttgcctgcca attattctta
     5161 ccaccctcaa ccttggcaag cttttctata gtcatttggt gaaatgtttc cagtttcttt
     5221 atctccatat cgaataactt cttttcataa ttcttaaatt tgtcttgttg caacctcgac
     5281 tagtacagaa tatcataaag aacagtatca tggcttcaaa atcttaaaag gccgtttttt
     5341 catcatgaaa tgtcttttta tcctctctac acttacgctg tgacaatagt taattaatta
     5401 agaagtttaa atgataccat tcatgctttt ataaatacct tttaagattt ttgatggtag
     5461 tgtaaaatat cttgtgtaaa cacacaaaaa ggaataaatc ctgtatagta gagttgcgac
     5521 acttactaga aagagattta ttcccatgac tcagtttacc acagaattac ttaacttcct
     5581 agcacaaaaa caagatattg ttctttcgct cctctttaga aatagctatg aatgacctct
     5641 tgcaagttga actatcagct tttcttggtt atgaatctta tgaaaaagaa ggctacaaca
     5701 caggtaatag ccgtaatggg acttattctc gtcagtttga aacaaagtat ggcttagtca
     5761 atttaatcat cccaagagat cgaaacggcg agttttcacc agttttatta ccatcttatg
     5821 ctagacgaga ggaccaattg gaagagatgg tgatcaaact ctatcagact agcgttacga
     5881 cacgcgaaat cagtgacatt attgagcgca tgtatggtca ccacttgttt ctgagtggaa
     5941 gcctcgttac aaaaaggtta tgacatcact tgaaacaacg gaaaatctcc taactttcta
     6001 tcaatttcca cattacattt ggtctagtat ttactctaca aacttgattg aatcactcaa
     6061 taaagaaatc aagcgacaaa gcaagaagga gggtggtttt tccaaatgaa gaagccttag
     6121 aacgatgtct tgtaagtatt ttcgaagatt ataatattaa gttcggagct cgtattcata
     6181 aaggattcgg agtatgtttt gacacacttg atagcttatt tgactaatat tcaaaaactc
     6241 tactcttgtg tttacacaac attattgaca gtctcaatta atctatatcc ctttaatatt
     6301 attaatttgt aatagtactt agtaagacat aaacaaatat cacaattaaa attactttac
     6361 ttgcattttc tcttacctct ttatccttca aaaaaatttg ggaaagtatt agacaaatta
     6421 aaccgagtat tataactata atcatatcat tgataagctg caattccaga tgctacacat
     6481 acaaatgctg ccgcacctcc agttattgga cctcctgctg cagctataag catcccacct
     6541 aagcaccctc cgatagcaga tccaatattt ccttttccac cagaaatatt tactaattct
     6601 tcaaactgta attctaaaaa attatccatt tttcacctca aaattatttt ccattaaata
     6661 acataccacc aacgcaagtt aatccacccg caatagcacc tacatgtgca cctgcaactc
     6721 ctccaacacc taaagtagcc aaccacctgc aatagcacct gaagtaatac caccaattaa
     6781 atgattttta caatctgtag cactataacc tccaataata tggaacaact cttctttttg
     6841 tatttcttct gcaaatttta tcataacttt aaaaaccttt ctaaaatgtt atattcatct
     6901 tgttgcaact ttgacaaact aaatatagca tattattata aaaatttttt tctatgtcgt
     6961 gaatggttgt ataaacatct caaataaact ttttaacata ttagagactg tcaataatgt
     7021 tgtgtaaaca caagagtaga gtttttgaat attagtcaaa taagctatca agtgtgtcaa
     7081 aacatactcc gaatccttta tgaatacgag ctccgaactt aatattatag tcttcgaaaa
     7141 tacttacaag acatcgttct cttttaggat atatgatatc tatctatatt aactattacc
     7201 tcaagagata ctttctaaaa actcaaatta ttagtgggaa aaacttagat tataaataca
     7261 aatgtcaggt ttattttatc ataaatcata cttttttaaa tctgagcaag tatatgacct
     7321 tctaaacgaa atacgtatgc gttatcctca tgctcatatt attctaatcg gaaatcatat
     7381 taattacgag gaaatattta aaaatcatta tcgagttttt ggtgttattg acacaacaag
     7441 tcataaatca ttaagatcca ttcgagacca aattcaactt tacttagacg aactttacaa
     7501 ttcgaataat ggataggcaa ttcatcaatt cttttaggaa atggttcttg tcaccccttc
     7561 caagtctatt gccacagtta ggttcaactt gcctaagtca tgcatggcta ggtggcaatt
     7621 cgtcataact ctaaaacaaa tgtttgatat ctgctagtat caattggaaa gaaaatcctg
     7681 ttaacattta acaaaattat tcagacttaa tcagaaaaat tggaagcaaa aaaagagagc
     7741 ataagctctc gaaacatcgt ctttcaaaaa tttttttaac aagccaatct ccaaaaatac
     7801 tccaactgtc ctagagagtt cttaatgccc catagcaaag ctatcagtaa aatattcctc
     7861 taacatcagg cgatgtttgg ctgagacact ctctaactct gctatctcct catgagagaa
     7921 aaactgtaac ttgagcgttt cctcattatg aaagttatca atagccatat cagagacagc
     7981 cgttagttca tagataaaga caatagtctg aacagcatca ccgttgggat aaacttcctc
     8041 aaaatgagtg taaacattca gtaaacgaac agcttcaacc tcaattccgg tttcctctaa
     8101 gaactcacgt ttgcaagtct ctaaagagct ctcacccagt tccatagtgc caccaggaat
     8161 agcccaggtt ttcttatcac cacgcaactg catcagcacc ttgccgtcat cattggtcaa
     8221 aatcccacca gcaaagttaa gaataatctt atcatgccca actttggagc ggatataaga
     8281 aatgtagtct tgtggcatat gatctcgctt tactatgtta gtattctttc tcattatagc
     8341 caaaatcagc taaatcaagc tttttatccc gccagttttt cttgactttg acccacgttt
     8401 ctaagtagac cttgtcacct aacatgagtt caatatcacg gcgcgccatt tttccgattt
     8461 ttttgagcat ggctccttgt tttccaatga tgatgccttt ttggctatcg cgctccacca
     8521 taatggttgc acggatatgc actttatcag tctcttcatc tcgcttcatg gattcgacaa
     8581 caacagctac ggaatgtgga acctcttgtt gcgtcaaatg cagtaccttc tcacgaacca
     8641 tttctgacac aaggaaacgt tctggatgat cagtaatctg atcttctgga aaatattgga
     8701 aaccttcttc aagattatca gttaataact tgatcaaagt tggcacatta ttaccttcta
     8761 gggcagaaat tgggaccact tctttaaaat ccatttggct acggaagtca tcaatctgtt
     8821 ccaaaagttg gtctggatga accttatcaa ttttgttgat aactaaaata acaggaatct
     8881 tagctgcttt tagccgctcg ataatcatgt cgtcaccctt accacgcttt tcatcggcag
     8941 gaaccatgaa aagaaccgtc tcaacttcac gtaaagtact ataagcagat tcaaccataa
     9001 aatcaccaag ggcggtcttt ggtttatgaa tacctggcgt atcaataaag acaatttgtt
     9061 ctgtttctgt ggtgtaaatg cccataattt tattacgggt ggtctgagcc ttgtcactca
     9121 tgatggcaat tttttgcccc atgacgtgat ttaaaaaggt ggatttgcca acatttggac
     9181 gaccaagaat ggctacaaag cctgatttaa acatagataa ttacgggcct tagcggtagg
     9241 gcttcagatc aaacttgtca ctaagcttaa ccgtcttgtc ctttccttat tctcctatgc
     9301 catcatcaca taggatagcc cattcctttc tttttaatga acgaaaatat tccaaatttt
     9361 aggaataaaa ataataagtc ctgtcaagac agcatagcca gaaatcatca aaacagcacc
     9421 tgctgccata tccttggcat ttttagctag catagaaaag tgatagtcac tagccaaatc
     9481 aactacattt tcaatagcag aattgacaat ttctaaggta atgaccaaaa aaatggctag
     9541 aagtaaaaat aaccattcga tggctgaaat gctaaaaaat aaaccagcaa cacaagctaa
     9601 acaggcagac aaaaggtgac ttctgagatt gcgttcttcc ttaaaagctg tgaaaacccc
     9661 tgtcaaggca aactccaggc ttgaggtaat ggttctgttt ttccatttcc gtttggtggt
     9721 attattgtcg tgtaaggcca taagcagtca aaatctcttc ctgtaaggta aacatctctt
     9781 tttcttcttc aagggtgtag tgatcatacc cattaatatg taagaatcca tgaacagcta
     9841 aaaatcccat ttcacgctca aaagagtgcc catattcttg ggactgctca cgcgccttgt
     9901 caatagaaat aaacaattcg ccaatataag catcaaactc tgccatcatc tctgccaaac
     9961 taggatcagc agccaaatcc tcttgactaa ataaaatagg cgtttctggc ttatattcta
    10021 gagaaatcac atctgttgga cgatcagtat ctcggtattc taagttgagt tcatgacttc
    10081 tttcattggt cacaaaggtc acagacattt ctttttcttc tttgcccgtc ttttgagcag
    10141 caaaattgag caaatcaagt gtttgctcca taatctcttg cgaaacttgt cccgtttcgt
    10201 caatcatctc gatatacata aggttaattg ttagggaagg gctgcccacc tcatttggta
    10261 tgttgggcac ccattattat ctgacagata atttccctta tcctttcaat cagcatttgt
    10321 tatttaccca ttataccaca agccccttaa aaatgggaat gctaggtaaa tcagggccta
    10381 tttggttaga attgcctcca cacgtttttg caagataggt aataaatcct gctcaaacca
    10441 ggggttctta gctaaccaca attggtttct tggagaagga tgaacaagtg gaaaatagtc
    10501 tggcaagtaa tcctcaaagt gacggactgt ttcagttaag gttttgtaag ccttgttacc
    10561 aaggtaaaag tcctgagcat agcgaccaac caaaatcgtc aattcaactt ctggcatcaa
    10621 tgctcttaat ggcgggtgcc acttagccgc aaaaccttct ctaggtggta agtcaccgga
    10681 ttttccctta ccaggataat agaaatccat agggataatg ccaaacaatc ctgagtggta
    10741 aaaggtgtca ttgtccacac ctagccagtc tcgtaagcgg atgccactac gatcattcca
    10801 gtaaagtttg gtttcttgag ctactattcc aggagcttgg ccaacaataa taatcctagc
    10861 tgtttgagga gcatcatata aaggaaaaat acctctttcg gtataggaga gattagcctc
    10921 atctgccata atagctttgg ttaaatcatc catagaatcc tccttaaaaa ggccatatta
    10981 aacatcatcg taaaggtctt agtgctcttg accgatcaca gggtattttg tcaagcctgg
    11041 ctggtaatca gcttcaacgt cactaacctt gggttttagt aagtccttcg tctcctctga
    11101 ggacgtttca taagccttga taatatcagc cacaacagga tgtcggacaa catctttagc
    11161 agagaaatag acaaaatcaa tctgtttaat gccttgtaat ttctgagtag catcaatcaa
    11221 accagacttg acatttcgag ggaggtcaat ctgactcgta tctccattga caatcatttt
    11281 agaattaaaa ccaagacggg tcaaaaacat cttcatttgc atgatggtcg tgttttgagc
    11341 ctcatctaag ataacaaaag cgtcatccag agtacgacct cgcatataag ctaacggagc
    11401 aatctcaatc acatctcgtt ccatcaggcg tgtggtttgt tccttgccta aaatgtgata
    11461 aagggcatcg taaacaggtc tgaggtaagg atccaccttt tctttcaaat cgcctggtaa
    11521 aaaacctagg ctttcgccag cttctaccgc aggacgcgtc aaaataatac gctttacctg
    11581 tcctcttttc agagcagtga ctgcaagcgt aacagctaag aaggttttcc ctgtccctgc
    11641 aggtcctaca ccaaaaacca catcatgacg tttgacacta tcaacatagg ttttttgacc
    11701 taatgttttg actcgtattg ccttaccata gttatcttta atgatttctt cttcataaag
    11761 cgccataaat tggtcaatct gatgagattc tgccatagat aaagctgtca ccacatctga
    11821 tgtgttgacc accatgccac gacccactag aaccagtagg gctt
//
