LOCUS       NZ_CAAHKQ010000003     22784 bp    DNA     linear   CON 11-MAY-2024
DEFINITION  Streptococcus pyogenes strain A904, whole genome shotgun sequence.
ACCESSION   NZ_CAAHKQ010000003
VERSION     NZ_CAAHKQ010000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (03-APR-2019) WTSI, Pathogen Informatics, Wellcome Trust
            Sanger Institute, CB10 1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900983695.1-RS_2024_05_11
            Annotation Date                   :: 05/11/2024 02:54:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,776
            CDSs (total)                      :: 1,717
            Genes (coding)                    :: 1,662
            CDSs (with protein)               :: 1,662
            Genes (RNA)                       :: 59
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 50
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 55
            CDSs (without protein)            :: 55
            Pseudo Genes (ambiguous residues) :: 0 of 55
            Pseudo Genes (frameshifted)       :: 29 of 55
            Pseudo Genes (incomplete)         :: 29 of 55
            Pseudo Genes (internal stop)      :: 25 of 55
            Pseudo Genes (multiple problems)  :: 23 of 55
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 15:26:47
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 60142
            Orig. end                         :: 82926
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CAAHKQ010000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22784
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22784
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22784
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12784](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12784)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    complement(130..148)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 24.33"
                     /tool="antismash"
     misc_feature    complement(667..680)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.38"
                     /tool="antismash"
     gene            complement(672..2222)
                     /gene="ftsY"
                     /locus_tag="E9664_RS02115"
                     /old_locus_tag="SAMEA3919112_00423"
     CDS             complement(672..2222)
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_function="GO:0005047 - signal recognition particle
                     binding [Evidence IEA]"
                     /GO_process="GO:0009306 - protein secretion [Evidence IEA]"
                     /codon_start=1
                     /gene="ftsY"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985588.1"
                     /locus_tag="E9664_RS02115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_00423"
                     /product="signal recognition particle-docking protein FtsY"
                     /protein_id="WP_136048033.1"
                     /transl_table=11
                     /translation="MGLFDRLFGKKETPKVAEEKLEENLLTETTQKEELSEKANEQSKI
                     EVVQQEDVSSEGAGSVENGPEAASVNAQVEEETGDNSNHPSEDTNEFAADKTDLKVSEL
                     SQSTASEPKDLVDQPVVEQFPTKQAQADASNDSANEEAVDTSKEQSSSQQVMEDYYRRK
                     AALEKSLQEKAAATVPVMPEEVPQENQASTSAEASQNKATHDTIPETDQEKYKRSLKKT
                     RTGFSARLNSFFANFRRVDEEFFEDLEEMLILSDVGVHVATTLTEELRYEAKLENAKKP
                     DALKRVIVEKLVDIYEKDGRYNEAINYQAGLMVMLFVGVNGVGKTTSIGKLAYRYKQEG
                     KKVMLVAADTFRAGAVAQLVEWGRRVDVPVITGPEKADPASVVFDGMEKAVAKGVDILL
                     IDTAGRLQNKENLMAELEKMGRIIKRVLPDAPHETLLALDASTGQNALSQAKEFSKITP
                     LTGLILTKIDGTAKGGVVLAIRQELDIPVKFIGFGEKVDDIGEFHSEDFMKGLLEGIL"
     gene            complement(2222..3046)
                     /locus_tag="E9664_RS02120"
                     /old_locus_tag="SAMEA3919112_00424"
     CDS             complement(2222..3046)
                     /EC_number="3.1.3.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1179: hydrolase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990612.1"
                     /locus_tag="E9664_RS02120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_00424"
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="WP_002990612.1"
                     /transl_table=11
                     /translation="MNIRILALDLDGTLYNTEKIVTDANKKALAAAREKGVKVVITTGR
                     PLKAIGNLLEELDLLDHDDYSITFNGGLVQRNTGEVLDKSSLSFDQVCQIQQALEAVGL
                     PTDIISGGDVYSIPSKDGRHSQYHLANPLLTFIEVTSVAELPKDITYNKIVTVTDPDFL
                     DQQIIKLSPSLFEDFEAFKSRDIIFEIMPKGIDKAFGLNLLCQHLGLDARHVMAMGDEA
                     NDFAMLEWAGLGVAMANGVSGAKAVADAVTTLTNDESGVAEAVKTFILEEES"
     gene            complement(3050..3847)
                     /locus_tag="E9664_RS02125"
                     /old_locus_tag="SAMEA3919112_00425"
     CDS             complement(3050..3847)
                     /EC_number="3.1.3.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1179: hydrolase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184306.1"
                     /locus_tag="E9664_RS02125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_00425"
                     /product="HAD family hydrolase"
                     /protein_id="WP_136022315.1"
                     /transl_table=11
                     /translation="MIKLIATDMDGTFLAEDGTYNKEQLAALLPKLAEKGILFAVSSGR
                     SLLAIDQLFEPFLDQIAVIAENGSVVQYHGEILFADMMTKEQYTEVAKKVLANPHYVET
                     GMVFSGQKAAYILKGASEEYIQKTKHYYANVKVINGFEDMENDAIFKVSTNFTGHTVLE
                     GSDWLNQALPYATAVTTGFDSIDIILKEVNKGFGMEHLCQALGIKKAETIAFGDNFNDY
                     QMLEFAGRAIATENARPEIKVISDQVIGHCNDGAVLTYLKGLV"
     misc_feature    3864..3879
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 20.04"
                     /tool="antismash"
     gene            4151..5276
                     /locus_tag="E9664_RS02130"
                     /pseudo=""
     CDS             4151..5276
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1164: transposase
                     IS3/IS911 family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076612023.1"
                     /locus_tag="E9664_RS02130"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="IS3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSTVKRYDEEFKQSLVNLYQTGKTQSELCKDYGVSASALAKWIKQ
                     YSQVKLEDNSVLTAKQIQELQKRNAQLEEENLILKKASAIFMQNLK"
     gene            complement(5390..6127)
                     /locus_tag="E9664_RS02135"
                     /old_locus_tag="SAMEA3919112_00428"
     CDS             complement(5390..6127)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000568302.1"
                     /locus_tag="E9664_RS02135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_00428"
                     /product="ABC transporter permease"
                     /protein_id="WP_023612112.1"
                     /transl_table=11
                     /translation="MNDYFKAEWLKTRKGAILAVGIIFLVLSSFIGLANFFLNYEVLIE
                     EQMSRVLWGQLTFYNSQLLFPAMLAIFSGMIILPEFERKTFEMLRANQVSVKKMLLSKF
                     LLALLLITVIQVLLFVIYLVTLKLSQIPFVAKDLLLFLRATVLSVIGSSSVVMIHSYIM
                     AKTKNFSKSVGIAAIGSFCGFIFIMLGGVINQFFPYSQPMIGIRSRALVDMSISEFVIF
                     IVVNALYSFIFFKLTLRTLEKNG"
     gene            complement(6120..6884)
                     /locus_tag="E9664_RS02140"
                     /old_locus_tag="SAMEA3919112_00429"
     CDS             complement(6120..6884)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000598724.1"
                     /locus_tag="E9664_RS02140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_00429"
                     /product="ABC transporter permease"
                     /protein_id="WP_085613743.1"
                     /transl_table=11
                     /translation="MIKAIQIELLKSKRTKSFMISFIMMLVAVMWSLLAASRSIDIPKL
                     RTIGLFFNNLQANSIFLPIATCLFVSRIVGNEKEGSTFKLQEANNTNLIIIFTRKLIFT
                     NSVFLLLNIFQVLIVYLNVLRYDIQVPIWTLILQVVGLTMSSFTLITLFLYLSIILEKQ
                     GILLGIGFLSGFFGMITSQTLKWINLIFPFGGSSFLALYRIKILNSSDSLDYIFSWDKS
                     VPLNYTLYLIYCVMIYSVVKYLLKKKKGDNNE"
     gene            complement(6886..7794)
                     /locus_tag="E9664_RS02145"
                     /old_locus_tag="SAMEA3919112_00430"
     CDS             complement(6886..7794)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002263495.1"
                     /locus_tag="E9664_RS02145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_00430"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_085613744.1"
                     /transl_table=11
                     /translation="MKNAIELRKLSKVYQDITTVDLEKITVREGEIYGFLGPNGAGKTT
                     TMKMILSLVSPTLGEILINGEDIKGNHAYLSVIGSMIEEPSYYPNLTGYENLLVFQKMV
                     GFDESNIWPTLALVGLAEENNRKKLVKAYSLGMKQRLALAFALVKKPKILLLDEPTNGL
                     DPAGIHEIRELIVKLAKEKGLTVFISSHILSEIEHIADRVGIINHGRLVYEGEIEAIKS
                     NTWIEIGGDFSQNNIVQSLINYGQVEVLGASASHVKFKNIDNDKLADVVTYLIENDYRI
                     FRVVRESENLEDIFLSLTKEV"
     gene            complement(7906..9978)
                     /locus_tag="E9664_RS02150"
                     /old_locus_tag="SAMEA3919112_00431"
     CDS             complement(7906..9978)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002268663.1"
                     /locus_tag="E9664_RS02150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_00431"
                     /product="cysteine peptidase family C39 domain-containing
                     protein"
                     /protein_id="WP_136021209.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1e-39, bitscore:
                     128.7, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIILQNNEEDCLLACYTMLLNDLGHKVPLYEIYDKDTLPADGLN
                     VSYLLSLSDRFGVKINAYHASFDELLKVYGEKKQRMILHWNNDHFVVLEKITSNKTVIV
                     DPAIGRIKYSRDEFLTHYSETMVSVNKRNNFHPQTYKKIFWKYFKQTLQLKPIALFLLS
                     LLFIQVSVLLFSVILRQMLAEDFKFGISLFLLGAVLTFQLLGYFIKNGALDRYNTDFDK
                     YYSKELFQRLLQKPLLYFRNHLSGGVSEKISFKSTLRDNVTLKIIPSCVSLISAIIIFA
                     YLMTISIKLSVILILMIASYSIISTLLYHRQNEYNQTYLQYLIDFNSEIQTDLDDIDYI
                     KIMRREKTVFHSWMEQNNQVTKKYSQILKIENLSQLIGTIFNYISLSSIIVIAVYYKDY
                     INLSLPDLLVYQTSISLLISAIEQVKGAVFEVIRLGVYAEKQSDLLKDTSPIVVPSSQS
                     DDYLIKTKNLNFSYGNKPIYSDVNLTISKGEKIAIVGKSGSGKSTLLLMLAGMLRYDGS
                     LEYGIEKFKDNLRVVLQNMTPRKGTVLENLEWTLDDVTPLYQVLNDTTADEVIARLPNK
                     IHSRLLKQGKNLSGGQIQKLLIAKSLLKENSIIFWDEAFSNLDEQSKNKIYDNVLQNNR
                     YSDRTMLIVSHHLDIVNYVDSIIFIDNETGKVIKDTHEHLMETNVNYTNFITSKN"
     gene            complement(10001..12784)
                     /locus_tag="E9664_RS02155"
                     /old_locus_tag="SAMEA3919112_00432"
     CDS             complement(10001..12784)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002303301.1"
                     /locus_tag="E9664_RS02155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_00432"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_136040419.1"
                     /sec_met_domain="DUF4135 (E-value: 2e-80, bitscore: 264.0,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.1e-67, bitscore:
                     221.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPKELLYSQFDRFPKVVIENNFPELLNESSELIKDVEDEISDYY
                     RSTLIYLINEKRIDKNLIGDSPESRYEYFNNVLCQNGLIFEEIDRRFPSINQRVMSTIK
                     KRLELINFVKERFTLDFKELRETGYIYSEAQTPKISEVKIKITGDIHNGCGVCILSYEE
                     QKVVFKKKSSNPNVLLHELNIEVGKFLQKDIDFIPDFLDKGEYFWEKFVSSSPLRTEED
                     AKEFYRRMGYLLSYSYILNISDLHFENLISTSFSPKLVDVETVFSVSPYQTVANNESTL
                     EIINNSRNSVLSTGLLPVSEAGKVFGGDTSGVLGGTLIGEAKIVINHNRDDIHVEKQKF
                     KTENQDHLPYFIDSKGMKEFLNAEDYVEYIKEGFREVSYFFMNSQDFLKKLYIKHNDIK
                     TRILFRNTRDYSLVRQLLVSPVYCEQSEILFETMANKLSEQNSRSLCLSEKKQLLNMDI
                     PYFYSNIDSCDIKDENMIIWNLESSALSEAINKLEKLSEEIINEQIELIEFSIKTPKAL
                     YSTELQEAYQKFEKVSSSENIIKTGIDTLVDIILENESNSLKDDSTNWLTLKVTDYDAF
                     ELVPMDDSLYEGLSGIAISLSEAYDFLDSERQRRVKECLKRIFSVLSNSYMKLPNHSFF
                     VGKLGIYSALKRISVVTGQEIQNSIMNYNNLKYTLDVDVLSADFLSSFPNEITALRNSD
                     IKIYNLTQALDKLKELAIVQKDFLSWDKLESNNVSLAHGNLGVEIALLYLAGKLESPEA
                     LNLFHKAKMFDKHQKLENGWIDKRNSSTSANWCHGSTGVLVARLAQLKLDDEYSLLSHS
                     ERIELENDMKHAAKQILEIGFDMTNFSLCHGTSGNLLALTYYQSYLTGADSEKLKEILD
                     REYRKLHSFGLENGWMCSFNTKYNVYGLMTGVSGILFSTVKYMKGDDSLDVLIPNF"
     gene            complement(12805..12960)
                     /locus_tag="E9664_RS02160"
                     /old_locus_tag="SAMEA3919112_00433"
     CDS             complement(12805..12960)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) leader_d"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002268661.1"
                     /locus_tag="E9664_RS02160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_00433"
                     /product="lacticin 481 family lantibiotic"
                     /protein_id="WP_023612118.1"
                     /sec_met_domain="L_biotic_A (E-value: 1.1e-25, bitscore:
                     82.6, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="leader_d (E-value: 2.6e-06, bitscore:
                     20.9, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEEKMCLGALNALQEFQIEELDNLLGGRGHGVNTISAECRWNSLQ
                     AIFTCC"
     CDS_motif       complement(12880..12960)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEEKMCLGALNALQEFQIEELDNLLGG"
                     /locus_tag="E9664_RS02160_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(12805..12879)
                     /prepeptide="core"
                     /locus_tag="E9664_RS02160_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="3.80"
                     /molecular_weight="2594.9"
                     /monoisotopic_mass="2593.2"
                     /core_sequence="RGHGVNTISAECRWNSLQAIFTCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEEKMCLGALNALQEFQIEELDNLLGG"
                     /leader_location="[12879:12960](-)"
                     /alternative_weights="2613.0"
     gene            complement(13159..13314)
                     /locus_tag="E9664_RS02165"
                     /old_locus_tag="SAMEA3919112_00434"
     CDS             complement(13159..13314)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) leader_d"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000410306.1"
                     /locus_tag="E9664_RS02165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_00434"
                     /product="lacticin 481 family lantibiotic"
                     /protein_id="WP_136048034.1"
                     /sec_met_domain="L_biotic_A (E-value: 5.1e-27, bitscore:
                     86.9, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="leader_d (E-value: 4.9e-07, bitscore:
                     23.1, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKEHEIINSIQEVSLEELDQIIGAGKNGVFKTISHECHLNTWAF
                     LAICCS"
     CDS_motif       complement(13240..13314)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTKEHEIINSIQEVSLEELDQIIGA"
                     /locus_tag="E9664_RS02165_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13159..13239)
                     /prepeptide="core"
                     /locus_tag="E9664_RS02165_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="5.20"
                     /molecular_weight="2808.2"
                     /monoisotopic_mass="2806.4"
                     /core_sequence="GKNGVFKTISHECHLNTWAFLAICCS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTKEHEIINSIQEVSLEELDQIIGA"
                     /leader_location="[13239:13314](-)"
                     /alternative_weights="2826.3"
     gene            complement(13345..13500)
                     /locus_tag="E9664_RS02170"
                     /old_locus_tag="SAMEA3919112_00435"
     CDS             complement(13345..13500)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) leader_d"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000410306.1"
                     /locus_tag="E9664_RS02170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_00435"
                     /product="lacticin 481 family lantibiotic"
                     /protein_id="WP_023612114.1"
                     /sec_met_domain="L_biotic_A (E-value: 9.6e-29, bitscore:
                     92.5, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="leader_d (E-value: 4.9e-07, bitscore:
                     23.1, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKNNEVINSIQEVSLEELDQIIGAGKNGVFKTISHECHLNTWAF
                     LATCCS"
     CDS_motif       complement(13426..13500)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEKNNEVINSIQEVSLEELDQIIGA"
                     /locus_tag="E9664_RS02170_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13345..13425)
                     /prepeptide="core"
                     /locus_tag="E9664_RS02170_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="5.20"
                     /molecular_weight="2778.2"
                     /monoisotopic_mass="2776.3"
                     /core_sequence="GKNGVFKTISHECHLNTWAFLATCCS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEKNNEVINSIQEVSLEELDQIIGA"
                     /leader_location="[13425:13500](-)"
                     /alternative_weights="2796.2"
                     /alternative_weights="2814.2"
     gene            13698..14396
                     /locus_tag="E9664_RS02175"
                     /old_locus_tag="SAMEA3919112_00436"
     CDS             13698..14396
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002294154.1"
                     /locus_tag="E9664_RS02175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_00436"
                     /product="response regulator transcription factor"
                     /protein_id="WP_085613747.1"
                     /transl_table=11
                     /translation="MNFESQLLNKRILIVDDDVALSKSIKEVLISRDFKNISCAYSISE
                     GIDIFSVSKIDLIILDVMLPDGEGHLLAKYIRKYSDVPILFLTAKNNPDDEIRGLESGG
                     DDYVTKPFLPKSLTYRIIALLRRAYKDESELIELTNCTIDLNNASVEKNGQHLSLTPTE
                     IQILRKLFSNKNYIASTESICDTVWGLESLGYEKSLMVHIRNIREKIEITPSKPNHLIT
                     VKGLGYKLVI"
     gene            14414..15775
                     /locus_tag="E9664_RS02180"
                     /old_locus_tag="SAMEA3919112_00437"
     CDS             14414..15775
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677788.1"
                     /locus_tag="E9664_RS02180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_00437"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_136048035.1"
                     /transl_table=11
                     /translation="MNIFKKNILKFILSFFFIIIIDVILLITATNYIRSQQSASTIIET
                     VSSEITLSSNGKYNVSSKAKQLIDDKKLWIMIIDKDSGKEKFNINKPQIIENQFDFADA
                     IRFSRFYLKDYPVFTQIKDNDIYIIAFPKDSIIRYSSNYFELNRVQIFPILILSIIFAN
                     CLFCLFLYIYSVTFLNRNIKPIINAITKLPNGINTQVKSVRELDKLTLAINSANQQLRE
                     NEEFKENWISGIAHDIKTPLSVIVSNTSLAIEKTNDDEFLKHLKPTLVESHYIQNLLND
                     LNIFARLTNGNLKLNHEIVDIIPFFKEIIIQIINQEIWEDFNFEFIPDSKLLGKKIYIE
                     KALISRVVHNLIYNSVLHNHSGCDIKIILEYLPEDCFSITIRDNGIGTSPERLKNINKI
                     EEFNFDMSGVRRSGMGLKISKQIIDLHDGNMIITSTQGQYFQTVITLPIESLNT"
     gene            complement(15991..16506)
                     /locus_tag="E9664_RS02185"
                     /old_locus_tag="SAMEA3919112_00438"
     CDS             complement(15991..16506)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF022534.4"
                     /locus_tag="E9664_RS02185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_00438"
                     /product="helical hairpin domain-containing protein"
                     /protein_id="WP_322972656.1"
                     /transl_table=11
                     /translation="MSFKTDCNTQSFVYFYSIHSLPYRKRVTLETLKEKVEKINLLMEI
                     HTPNQTFLETKDQLVQEIATLDMKIEEIQEKIATLNKMAEVFINLESDNKEGKRLARYN
                     LTKTNILLTIKVDQVEREIEQLQISLTERLDEYEGKVSELEEFVQMLNTLELPLTDRDH
                     LDRNRLAF"
     gene            16526..17652
                     /locus_tag="E9664_RS02190"
                     /pseudo=""
     CDS             16526..17652
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1164: transposase
                     IS3/IS911 family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076612023.1"
                     /locus_tag="E9664_RS02190"
                     /note="programmed frameshift; internal stop; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="IS3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSTVKRYDEEFKQSLVNLYQTGKTQSELCKDYGVSASALAKWIKQ
                     YSQVKLEDNSVLTAKQIQELQKRNAQLEEENLILKKASAIFMQNLK"
     CDS             complement(17796..17879)
                     /gene="allorf_077938_078021"
                     /locus_tag="allorf_077938_078021"
                     /protein_id="allorf_077938_078021"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MKLETEYFCLSIPLNEQLYRKVIGCLE"
     CDS_motif       complement(17853..17879)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKLETEYFC"
                     /locus_tag="allorf_077938_078021_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(17796..17852)
                     /prepeptide="core"
                     /locus_tag="allorf_077938_078021_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.00"
                     /molecular_weight="2070.4"
                     /monoisotopic_mass="2069.1"
                     /core_sequence="LSIPLNEQLYRKVIGCLE"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKLETEYFC"
                     /leader_location="[17852:17879](-)"
     gene            complement(18022..18981)
                     /locus_tag="E9664_RS02195"
                     /old_locus_tag="SAMEA3919112_00441"
     CDS             complement(18022..18981)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560542.1"
                     /locus_tag="E9664_RS02195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_00441"
                     /product="hypothetical protein"
                     /protein_id="WP_115230812.1"
                     /transl_table=11
                     /translation="MSRCIANLPQQIPVKWIQEGVLFRDRIPTYKGYRRQFNQILLGAW
                     GIESAYVDAEIIVATWRGLQRFKGIKVEFIQLSNKNIFDVLEKDLSKKLRFEDISIEAI
                     LGKYLCNNDIEIIKCLYEKDKINMELLISLISKISNKLVKQEFIKVLVLYEYVKNFLPA
                     DCIYFSLSNLYGTGHYSSMNYKIFIRTKSGDIFDIADGGRIDDMVSKFNKVNVLGVCMG
                     IGTTVLSQEIEYEIEDRIMILVEKIDVKIYKNCLELANKLSGYHCSVFEFPYKKIKKFF
                     KHELYSRHHYIIVRLDGSMEYRFSSVALKNKIKSILDS"
     gene            complement(19157..20182)
                     /locus_tag="E9664_RS02200"
                     /old_locus_tag="SAMEA3919112_00442"
     CDS             complement(19157..20182)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014114.4"
                     /locus_tag="E9664_RS02200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_00442"
                     /product="S66 peptidase family protein"
                     /protein_id="WP_306460906.1"
                     /transl_table=11
                     /translation="MCLFGKQGIRCARKGDERNIKIIVNRVNSERNIKSIGICSPSYPG
                     TFHYQKRYKRGVEFLQNKGFTIVEGNLTGKEGYRGEISGGVQDRAEELNQLIPRVDVIM
                     TSIGGYNSNSVLKYIDYDLFKQKSPIFIGYSDTTALALALYKKTGCITYLSQSVISNFG
                     EFEPFNELNYFYFDFMLQSKCETLMVQIPDVWTDEWINWETYERTKKTNKNEWIIFNKG
                     EFNGTLIGGNLDTIVGIIGTEYMPKITEDTILLLEDVYTDLGRLYRNFTTLALHGIFDK
                     IGGLIISKFETIGENSDVINDIINEFVGHRKIPILLNFDCGHTHPSCLMPIGGKITLSL
                     S"
     gene            complement(20101..21348)
                     /locus_tag="E9664_RS02205"
                     /old_locus_tag="SAMEA3919112_00443"
     CDS             complement(20101..21348)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285438.1"
                     /locus_tag="E9664_RS02205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_00443"
                     /product="acetyl-CoA carboxylase biotin carboxylase subunit
                     family protein"
                     /protein_id="WP_011285438.1"
                     /sec_met_domain="ATP-grasp_3 (E-value: 1.7e-09, bitscore:
                     31.2, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 3e-10, bitscore:
                     33.2, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKNILIVGGGPEITICYDLINNSTEYNFFSVSEIPTMYPELFVE
                     TIETSFRNFGKTIEQIKELKYSIDAVACWDEALTHIADDISKELGLNPISSLDSQSFRF
                     KDRMRMVCEAGGLKMPKYKIINQFSDTNKIINWKYPLIVKPTSFLASIGVKKVYNFSEL
                     QQAVSQMLNVKFPVYIASGVYELGELYNLEPRVLVEEFIDGEEYSLESVVRNGIYTPLG
                     ITKKIVDEKLFMDEIGHIFPSNLNKEEKSRVYSWAEKLHQILQLNHITTHTEFRIGRNG
                     DIILIEIGARIGGDCIPNLMKNSFIVKGFDFYNTYLKARLGLQEELNTDTNKFSGIVFF
                     RLNPENYGKIFNGVSYDAPKTSLIFEEKIYKKEGTVLPNPINWSNERVGYVCLENKEYA
                     VLEKEMKEILKSLSIE"
     gene            complement(21362..22258)
                     /locus_tag="E9664_RS02210"
                     /old_locus_tag="SAMEA3919112_00444"
     CDS             complement(21362..22258)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF005053.0"
                     /locus_tag="E9664_RS02210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_00444"
                     /product="asparagine synthetase A"
                     /protein_id="WP_085613751.1"
                     /transl_table=11
                     /translation="MTFFKNEGISTVHLPITTSSITSPMGLGSDSLPVKISLFDVDTYL
                     ADSMQFHLEYILRLFPKSGVHYLMPTFRGEAVDHRHLSQFYHSECEIEGDLHYVMNLVD
                     RYIKFLVSEILRECRDSIFAITKDVSHLESFIDRKIPIITFEEACTILENEIDSLEYND
                     EHHFYVLTDVGEKKLMEHFEGVVWVKNYPCKSVPFYQRFSTDHLFAYNADLLLGIGETV
                     GCGERCETYEEVVENMNYLQVDASEYSWYLEMKKTRPMKSSGFGLGVERLIAWILKCDD
                     VRKVQLISRENGIDYLP"
     gene            complement(22210..22548)
                     /locus_tag="E9664_RS02215"
                     /old_locus_tag="SAMEA3919112_00445"
     CDS             complement(22210..22548)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285437.1"
                     /locus_tag="E9664_RS02215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919112_00445"
                     /product="Fic family protein"
                     /protein_id="WP_023078733.1"
                     /transl_table=11
                     /translation="MKPPFTVTNTMLNKVVEISKIIGNLELQVQKDLKLRKENRIQSIH
                     SSLAIEQNSLTVEQITAIIDGKRVLGNPREIREVKNAYEAYEEILTLTPYDESHFLKMK
                     EFQQYIYR"
ORIGIN
        1 caaccctttc ttgatattcg cattctcaaa attccctctc taacctttgg cctgattccc
       61 ttttttgtct tccagctgat taatttaggc ataaattttc taacgccaaa ctttattgtc
      121 atggaaaaga ttgctaatag ttctcaagct ggtatggtgt tactacctgg taccttactc
      181 ggagctctac tagcacctgc ttttggtaaa ctttatgatc aaaaaggagc aagactttcg
      241 ctttatttag gaaatgcctt atttagttta tcattgatta ttatgacact tcaaacaaga
      301 cattttatgc ttttaccatt cactctttta tatattttat tcacgtttgg gcgtaacatg
      361 ggctttaata atagcttagc cacggctatt cgagaattgc ctgccgagaa aaatgccgat
      421 gccacggcca tttttcagat gatgcagcaa tttgctggcg ctctaggaac tgctatggca
      481 tcactgatag caaatagtca accagaattc acaagcggtg tccagtctgt ctaccttctc
      541 tttactattt ttgctctact tgattttatc tttttctttg ctatgtttta ccatttaggg
      601 aaaaaaggac ttgcctaagc tgacttactt aaaaaccagc ctcgttctgt tgaacaagac
      661 tggttttttt cttataaaat accttctaaa agacctttca taaagtcttc tgagtggaat
      721 tctccaatat catccacttt ttcaccaaat ccgatgaact tgactggaat gtctaattct
      781 tgacggatgg ctaggactac accacctttg gccgtgccat caattttcgt taaaatcaaa
      841 cctgttaatg gtgttatttt tgaaaattcc ttggcttggc taagcgcatt ttgacctgtt
      901 gacgcatcta aggccaaaag cgtttcatga ggggcatctg gtagcacgcg cttaatgata
      961 cgacccattt tttccagctc tgccatgaga ttttctttgt tttgcaggcg accagccgtg
     1021 tcaatcagga gaatatctac accttttgcc acagcttttt ccatcccgtc aaaaacaaca
     1081 gacgctggat cagccttttc agggccagta atgactggca catctactcg gcgtccccat
     1141 tcgactagct gagccacagc ccctgctcgg aaggtatctg ctgccaccaa catgactttt
     1201 ttaccttctt gtttgtaacg gtaagccagc ttcccgattg aagtcgtttt accaaccccg
     1261 ttaacaccta caaaaagcat aaccatcaag ccagcttgat aattaatggc ttcattataa
     1321 cgcccgtctt tttcatagat atctaccaat ttttccacaa tcacacgttt caaggcatct
     1381 ggttttttcg cattttccag tttggcttca taacgcaact cctctgtcaa agttgtcgcc
     1441 acatgtacac cgacatctga taagatcagc atttcttcca agtcttcaaa gaattcttca
     1501 tccactcgcc tgaaattggc aaagaaactg ttcagacgag ctgagaagcc agtccgcgtt
     1561 tttttcaagc tacgcttgta tttttcttga tctgtctcag gaatggtatc gtgggttgcc
     1621 ttgttttgag aagcttctgc tgaggtagag gcctgatttt cttgtggaac ttcttctggc
     1681 atcactggaa ccgttgccgc tgctttttct tgaaggcttt tttcaagagc agccttacga
     1741 cgatagtagt cttccataac ctgttggcta ctggattgct cttttgaagt gtctactgct
     1801 tcttcattcg ccgaatcatt tgaggcatca gcttgagctt gttttgttgg aaactgttcc
     1861 acaactggct ggtcaacaag gtcttttggt tctgatgccg tagattgact aagttcactt
     1921 accttaaggt ctgttttgtc ggcagcaaac tcattggtat cttctgatgg atgattacta
     1981 ttgtcacctg tttcttcctc aacctgtgcg tttactgaag ctgcttcggg accattttcc
     2041 accgaacctg cgccctctga agaaacgtcc tcttgttgaa ccacctcaat cttgctttgc
     2101 tcattggctt tttcagaaag ctcctctttc tgagttgttt ctgtcaaaag attttcttct
     2161 aacttttcct cagctacctt cggggtttct tttttcccaa ataaacgatc aaataatccc
     2221 attaactctc ctcttctaaa ataaatgtct tcacagcttc tgcgactcca gactcatcat
     2281 tggtcaaggt ggtcacggca tcggcaacgg ctttagctcc tgaaacacca ttagccatag
     2341 ctactccaag tcctgcccat tctaacatcg caaagtcgtt agcttcgtct cccatagcca
     2401 tgacatgtct agcgtcaagg ccaagatgct ggcaaagcaa gtttaatcca aaagctttat
     2461 caatgccttt tggcatgatt tcaaaaataa tatctcgtga tttaaaggct tcaaaatcct
     2521 caaataagct tggggatagc tttataatct gctgatccaa aaagtctgga tcggtgactg
     2581 tcacaatttt gttataggta atgtcttttg gtagttccgc tacagatgtc acctcaataa
     2641 aggtcaacag tgggttagct agatggtact gcgaatgcct accgtcctta cttggaatgc
     2701 tatacacatc cccaccactg ataatatctg ttggtaagcc aaccgcctct aaagcttgct
     2761 gaatctggca gacctggtca aaactgagag aactcttatc caaaacctcc cctgtatttc
     2821 gctgaaccaa acccccatta aaggtaatac tgtagtcatc gtggtcaagc aagtccaact
     2881 cttctagcaa gttaccgatg gcctttagag ggcgacctgt ggtaataacc accttaaccc
     2941 ctttttctct agccgctgct aaggcttttt tattggcatc tgtgacaatt ttttcagtgt
     3001 tgtagagggt accgtctaaa tcaagcgcca aaattctaat attcatgagt tacactagtc
     3061 cttttaaata cgttagtact gctccgtcat tacagtggcc aatgacttgg tctgaaatca
     3121 ctttgatttc aggtcttgca ttttccgtag caatagccct accagcaaac tccaacatct
     3181 ggtaatcatt aaaattatcc ccaaaagcaa tcgtttctgc tttcttaatg cccaaggctt
     3241 gacaaagatg ctccatacca aagcccttat tcacctcttt taagataata tcaatggaat
     3301 caaagccggt ggtcactgca gtggcataag ggagggcttg attcaaccaa tcgcttcctt
     3361 ctaagacggt atggcctgtg aagttggtag aaactttaaa aatggcgtca ttctccatat
     3421 cttcaaaacc attaataacc ttaacattag catagtaatg ttttgttttt tgaatgtact
     3481 cttctgatgc gccttttaaa atataggctg ccttttgccc agaaaaaacc atacctgttt
     3541 ctacatagtg aggattggct aaaacctttt ttgcaacttc ggtatactgc tctttggtca
     3601 tcatatctgc aaatagaatc tcaccatggt attgaaccac ggaaccattt tctgcaataa
     3661 cagcaatctg atccaaaaag ggctcaaaga gctgatcaat ggctaagagc gagcggccac
     3721 tcgaaaccgc aaataaaatg cctttttcgg ctaactttgg caagagcgca gctagttgct
     3781 ctttattata agtaccatct tcagctagga aggtaccatc catatctgtt gctattagtt
     3841 ttatcataca atgtctcctt tttttactct aggggggtgc aaacgccatt tagggtgtgc
     3901 actttttaac gatttaaata agccccatca tttctgcatt ctgttcaatt tttcttatta
     3961 tatcataaaa agcagctttc attccattcg taaaaaacag ccagattata tttcgataac
     4021 ctgaccgttt ttgaagtgaa ctgctacttt tttattttta taaatgacca ctggatgtat
     4081 actataaaag tagacaaaac tttgtgtgtt acaatctgtt ttaaaagaca caaaaacgaa
     4141 aggacaacct atgtcaacag ttaaacgcta tgatgaagaa ttcaaacaat ctcttgttaa
     4201 cctttatcaa actggaaaaa ctcagtctga actctgtaaa gactatgggg tatccgcttc
     4261 tgcgcttgca aaatggatca aacagtattc ccaagtcaaa ctcgaagata attctgtact
     4321 tactgccaag caaatacaag agttacaaaa acgtaatgcg cagcttgaag aggagaacct
     4381 tatcctaaaa aaagcaagtg ccatattcat gcaaaactta aagtaagact cctcgctgtc
     4441 tatcggttac gctttgaaca cgccacaaca accttgtatc gtgttttacg tgtcaatcgc
     4501 tccacttact ataaatttct aaaacataag ccctcaaaaa gagaattgga taatcaaatt
     4561 tatagaaaac aaatacttga gatttatacc aaagcgaaca aaagacttgg cgtgaagtct
     4621 atcaaggtca ttcttcaaag agactatgac acaaaaatct ctgaaggaag aatttaccgt
     4681 cttatgaaga atatggcgct ccctaaaatg gctaccgtta agccaaaaac agctcttaaa
     4741 aggactcaaa aaactcccct caaaacttac tcaaccagaa atttaatcct gacaaaccta
     4801 atcaagtatg gtctactgac ttcacctata tttctattgg atataagaaa tatgtctatc
     4861 tctgcgcaat acttgatctc tattctagaa aatgtattgc ttggaaattg agtcatcgta
     4921 tggatgcaaa gttagcatgt gacactctag aattaactct taataaaaga aagattgaag
     4981 gaacacttct ctgtcattcc gaccaagggt cacaatttaa ggccagggaa ttgagaaaaa
     5041 taattgatga caacactatc atgcattctt tttctaaacc tggatatcct tatgataatg
     5101 ccgtaacgga agcatttttc aagtatttaa agcatagaca aatcaaccga aaaaagtatc
     5161 aaaatatcaa acaggttcag ttagactgct ttgaatacat tgagaatttt tataacaatt
     5221 acaacccaca tacggctaat ctaggactaa cccctaatca gaaagaagaa aattagttta
     5281 acgtaataaa ataacacggt tttctgtcta cttatttgac attagtccac atgctctcac
     5341 cttttccttc tataaattta gttacttctg taatgtataa aaatccactt tatccattct
     5401 tctctaaagt tcgtaatgtc aatttgaaaa aaataaaact atatagagca ttaacaacta
     5461 taaatattac gaactccgaa atgctcatat ctactaacgc tctactacgt atacctatca
     5521 ttggctggga ataagggaaa aattgattaa tgacacctcc caacataata aatatgaatc
     5581 cacaaaatga acctatagct gcaatcccga ctgatttaga aaaatttttt gttttagcca
     5641 tgatataact atgaatcatt acaacagagc tagaaccaat aacagatagc acagttgctc
     5701 ttaaaaataa aagtaaatct tttgctacaa acggaatctg gctcaatttc agtgttacaa
     5761 gatatataac aaataataat acttgtataa ctgttataag tagcaaagct aacaagaact
     5821 tactaagaag catcttttta acagatactt gatttgcacg taacatttca aatgtttttc
     5881 gctcaaattc aggtagaata atcatgcctg agaatattgc taacatagct gggaaaagca
     5941 actgactatt atagaaagtt aactgtcccc agagtactct actcatttgt tcctcaatga
     6001 gtacctcata attcaaaaag aaatttgcca aaccaatgaa actagataga acaagaaata
     6061 taatcccaac tgctaaaata gctcctttgc gagtttttag ccactccgct ttgaaataat
     6121 cattcattat tgtccccttt cttctttttc agtaaatact taactacgct atagatcatt
     6181 acgcagtaaa taaggtataa agtataattt aaaggcacgc ttttgtccca agaaaaaata
     6241 taatctaaac tatcactgga atttaaaatc tttattctat atagtgctaa aaaactcgat
     6301 cctccaaacg gaaaaataag gttaatccac tttaaagtct gggaggtaat cataccgaaa
     6361 aaacctgata aaaatccaat tcctaaaaga atcccttgtt tttctaaaat tattgataaa
     6421 taaagaaaga gagtgattaa agtaaaactg gacatcgtta aacctactac ttgtaaaatc
     6481 agagtccaaa ttggaacttg gatatcatat cttagtacat ttagataaac aatcaagact
     6541 tggaaaatat tcaaaaggag aaagacagaa tttgtgaaaa tcaatttgcg agtaaatatt
     6601 ataattagat ttgtattatt tgcttcttga agtttaaatg tactaccttc tttttcatta
     6661 ccaacaatac gtgaaacaaa taagcaagtt gcaataggta aaaaaataga attagcttgt
     6721 aaattattaa agaacaatcc gatagtccgt aatttaggaa tatcaatact tcttgaggct
     6781 gctaacaatg accacatcac tgctactaac atcataatga aagaaatcat aaaagatttc
     6841 gtacgcttac tttttaataa ttcaatctgt attgctttta tcatttcaaa cctccttagt
     6901 taaagagagg aaaatgtctt ctaaattctc gctttcccta acaactcgga aaatccgata
     6961 gtcattttca attaaataag tcactacatc tgctaatttg tcattatcaa tatttttaaa
     7021 cttaacatga cttgctgaag cacctaacac ttcaacctgt ccgtaattaa ttaaactttg
     7081 aacaatatta ttttgcgaga aatccccgcc aatctcaatc caagtatttg attttattgc
     7141 ttcaatttcc ccttcataaa ccagtctccc atgatttata atgcctactc ggtcagctat
     7201 atgctcaatt tcggataaaa tatgacttga gataaatact gttagccctt tctccttagc
     7261 taattttaca attaactcgc gaatttcatg aattccagcc ggatcaagtc cattagtagg
     7321 ttcatctaat aacaagattt ttggtttttt aaccagagca aaagccaagg ctaaccgttg
     7381 cttcatgcct aaagagtagg ctttcacaag tttttttcgg ttattttcct ctgctaaacc
     7441 aaccaatgcc aaagtcggcc agatattact ttcatcaaaa cctaccattt tttgaaagac
     7501 tagtagattc tcgtaacctg ttaaatttgg ataataggag ggttcctcaa tcattgaacc
     7561 gatgacactc aaataagcgt ggttcccctt tatatcctca ccatttataa gaatttctcc
     7621 tagtgttgga gaaactagtg acaaaatcat tttcattgtt gttgtttttc ctgcaccatt
     7681 cggtccaaga aaaccgtaaa tctcgccttc acgaaccgta atcttttcta aatctaccgt
     7741 agtaatatcc tgatagacct tagaaagttt tcttaattca atagcatttt tcatgttaat
     7801 aaccccataa taagaccctt caatgagtct cttcctttcc ttctattaca acattattgt
     7861 atctaagcaa cttaaagata acattaagaa aagagaaaca ttctcttaat ttttggaagt
     7921 aatgaaattt gtatagttaa catttgtttc cataagatgt tcatgagtat ctttaataac
     7981 cttaccagtt tcattatcaa taaaaataat agaatcaaca taattgacaa tatctaaatg
     8041 atgactaacg attaacatag ttctgtctga atatctattg ttttgtaaaa cattatcgta
     8101 aattttgttc ttactttgtt catctagatt actgaaagcc tcgtcccaaa aaataattga
     8161 attttctttt aaaagtgatt ttgctatgag taacttctgg atttgtccac ctgataaatt
     8221 ttttccttgt tttaagagtc tagagtgaat cttatttggt aatcgtgcta taacttcatc
     8281 agctgttgta tcattcaata cttggtaaag tggagttaca tcatctaaag tccactctaa
     8341 gttttctaag acagtcccct ttctaggtgt catattttga agaacaactc ttagattgtc
     8401 tttgaatttt tcgatgccat attcaagaga tccatcatag cgtagcatac ctgctaacat
     8461 taatagtaaa gttgacttcc cgctaccaga tttacctaca atggcaatct tttctccttt
     8521 actgattgtt aaattcacat cactatagat tggtttatta ccataagaaa agttcaaatt
     8581 tttagttttg attaaataat cgtctgactg tgaactaggt acaacgatag gtgaagtatc
     8641 ttttaataaa tcactttgtt tttctgcata tacacccaat cgaattactt caaatactgc
     8701 tccttttact tgttcaattg ctgatatcaa taaagaaata ctagtttgat aaactaatag
     8761 atcaggaagg gataaattaa tataatcttt ataatatact gcgataacaa ttattgagga
     8821 tagactaatg tagttaaaaa tagttccaat aagttgtgaa agattttcaa ttttaagaat
     8881 ctgcgaatac ttcttagtga cttgattatt ttgctccatc caggaatgga aaacagtttt
     8941 ctctcttctc attattttta tatagtcaat gtcatcaaga tctgtttgta tctctgagtt
     9001 aaaatcaatt aagtactgta aatatgtctg attatactcg ttttgcctat gatacaatag
     9061 agtagagatt atactatatg aagcaatcat caagattaat atcaccgaca acttaataga
     9121 tatagtcatc agatatgcaa agataataat agctgaaatc aaacttacac atgatggaat
     9181 aatttttaaa gtaacattgt ccctaagtgt tgatttaaaa ctaatttttt cagatactcc
     9241 cccacttaga tgatttctaa aataaagtaa aggtttttgt aataatcttt gaaacaactc
     9301 tttactgtaa tatttatcaa agtctgtatt atatctatct aatgcaccat tctttataaa
     9361 ataacctaat aattgaaaag ttaatactgc acctaaaagg aataagctga taccaaactt
     9421 gaaatcttca gctaacattt gtcttaaaat gactgagaac agtaaaacac taacttgaat
     9481 aaacaggagt gacaacaaga ataatgcaat cggttttaat tgtaaggtct gtttgaaata
     9541 cttccaaaag attttcttat atgtttgggg gtgaaaatta tttcttttgt taactgacac
     9601 catagtttcc gagtagtgag ttaaaaattc atcacggcta tacttaatac gaccaatggc
     9661 tgggtcaact ataactgttt tatttgacgt aattttttca agaaccacaa aatgatcatt
     9721 attccaatga agaatcattc tttgcttctt ttctccgtat acttttagta attcatcaaa
     9781 agaggcatga taagcattta ttttcacccc aaatctgtca cttagtgaca aaagatatga
     9841 gacatttaga ccatctgcag gcaatgtatc tttatcataa atttcatata atggaacttt
     9901 atgtcctaaa tcattaagta acattgtata acaagctaag agacaatcct cctcattgtt
     9961 ttgcaaaata atattcatat ctcatattcc tttctatctc ttagaaattg ggaatcaaca
    10021 catctaggga atcatcaccc ttcatgtact ttactgtaga aaataatatt cctgacacac
    10081 ctgtcattaa cccataaaca ttatattttg tattaaaact acacatccag ccgttttcca
    10141 ggccaaaaga atgcagtttt ctatactctc tatccaaaat ttcttttaac ttctctgaat
    10201 cagctcctgt taaatatgat tggtagtaag taagtgccag caaatttcca ctggttccat
    10261 ggcaaagtga aaagtttgtc atatcaaaac caatttcaag aatctgttta gcagcatgct
    10321 tcatatcatt ctctaattct atccgttcag aatgagaaag aaggctatat tcatcatcta
    10381 gttttaactg cgctaacctt gcaactaata ctcctgttga accatgacac cagttggcac
    10441 tagtcgagga atttcttttg tctatccagc cgttttccaa tttttgatgt ttatcaaaca
    10501 tttttgcttt atgaaataaa tttagtgcct caggactttc taactttcca gctaaataaa
    10561 gtaacgctat ttcaactcct aaattaccat gtgcaagact aacattattc gactctaact
    10621 tatcccaact aagaaaatcc ttttgaacaa ttgccaactc tttaagtttg tctagtgcct
    10681 gagtaagatt atatatctta atatccgaat ttctcaaagc agtgatttca ttaggaaaac
    10741 ttgatagaaa atcagcactt aaaacatcta catccaatgt atatttgaga ttattataat
    10801 tcatgataga attttgaatc tcttgtcctg taacaacact aattcgtttt aaagctgagt
    10861 aaattcccag cttccccaca aaaaaagaat gatttggtaa tttcatatag gaattagata
    10921 atacagaaaa aattcgtttt agacattctt taacccttct ttgtctttct gagtctagaa
    10981 aatcataagc ctctgataaa gaaattgcta ttccagacaa accttcataa agagagtcat
    11041 ccatcggaac taactcaaaa gcatcataat ctgtaacttt caaggtgagc cagtttgtac
    11101 tatcgtcttt tagagagttg ctttcatttt ccaaaataat atcaactaga gtatcaatac
    11161 cagtttttat tatattttca ctgctactaa ccttctcaaa tttttgatat gcctcttgaa
    11221 gttccgtact atataaagct ttaggagttt tgatagaaaa ctcaattaat tcaatttgct
    11281 catttatgat ttcttcactc aatttttcta atttattgat agcttcgctt aaagcagaac
    11341 tttcaaggtt ccaaataatc atgttttcat cctttatatc acaactatca atatttgagt
    11401 aaaaataagg gatatccata tttaaaagct gtttcttttc tgatagacat aaactacgac
    11461 tattttgttc agacaattta ttggccattg tttcaaataa aatctcggat tgctcacaat
    11521 aaacaggaga aactagcaat tggcgcacta agctataatc tcttgtattt ctgaacaaaa
    11581 ttctagtctt tatatcatta tgcttaatat aaagcttctt taaaaaatct tgtgaattca
    11641 tgaaaaagta gctgacttca cggaaccctt ctttgatata ttcaacataa tcttcagcat
    11701 taagaaattc tttcattccc ttcgaatcaa taaagtaagg caaatgatcc tggttttctg
    11761 ttttaaactt ttgtttttca acatgaatat catctcggtt atgattgata acgatttttg
    11821 cctctccaat taaggtgcct cctagaacac cactagtatc tcctccaaaa actttaccag
    11881 cttcagaaac aggaagcaaa cctgttgata ataccgaatt tctactatta ttaattatct
    11941 ccaatgttga ctcgttattt gcaacagttt gataggggct aactgaaaaa actgtctcaa
    12001 catcaactaa cttaggagaa aagcttgtag aaatcagatt ttcaaaatgc aaatcagaga
    12061 tattcaatat gtaagaatat gataataagt aacccatcct acgataaaat tcctttgcat
    12121 cctcctcggt tcttaacgga gaacttgata caaatttttc ccaaaaatac tctcctttat
    12181 ctaaaaaatc agggataaag tctatatctt tctgtaagaa tttaccaact tctatattca
    12241 gttcatgcaa gagaacattg ggatttgatg attttttctt aaaaactact ttttgttctt
    12301 cataactcaa aatgcagact ccacaaccat tgtgaatatc tccagttatt ttgattttga
    12361 cttcactaat ttttggagtc tgggcttcac tatagatata gcctgtctct ctcaactctt
    12421 tgaaatctaa agtaaatctt tcctttacaa aattaattaa ttccaaacgt ttcttgatag
    12481 tactcattac acgctgatta atagaaggga aacgtctatc aatttcttca aaaattaagc
    12541 cattttgaca tagtacatta ttaaagtatt catagcgtga ctctggagaa tctccaatta
    12601 ggtttttatc aattcttttt tcatttatta ggtaaataag agtggaacga taataatcag
    12661 aaatttcatc ttcaacatcc ttaatcagct cactactttc atttagcaat tctgggaaat
    12721 tattttcaat aactactttt gggaatctat caaattggct atataacagt tcttttggat
    12781 tcatattctt tactcctaaa catattaaca acaagtaaaa attgcctgta aactattcca
    12841 acgacattca gctgaaattg tattgacacc atgccctctt cctcccaaaa ggttatccaa
    12901 ttcctcaatc tgaaattctt gtaacgcatt caaagcacct aggcacattt tttcttccat
    12961 aattctttac ctcatttata tgacatcgag tagaactcga aatttgtttt ctttatacat
    13021 tgattttaaa tttgttacat aaagacaata ttaaggaaaa ctaaagttaa attaaatttt
    13081 ctacctatgt caatgcaaat aaaaaaagag gtccccctct tttttatgta acatcaaaga
    13141 cacctgaaca gtagagtttt atgaacaaca aatagcaagg aatgcccatg tattcaaatg
    13201 acactcatga gaaattgtct taaatacacc gtttttccca gcaccgataa tttggtccaa
    13261 ctcctcaaga ctaacttctt gaatagagtt aataatttca tgttctttgg tcataacgat
    13321 tttctcctta tattttatct aatattatga gcaacaagta gcaaggaatg cccatgtatt
    13381 caaatgacac tcatgagaaa ttgttttaaa cacaccattt tttccagcac cgataatttg
    13441 atcgagttct tcaagactaa cttcttgaat agagttgatt acttcattat ttttttccat
    13501 tttctatacc tcatttaact ttcttcagaa ggataggtgc cttcctcttt gttacaacct
    13561 tattttaaga tgataacttt aagacagaat aaagaaaaca taaatttaat tttaagatta
    13621 tacaacacaa gtcctactta ttctcttata tctataatct ttatggtata attttattac
    13681 actttaggag gtattgtatg aattttgagt ctcaattatt gaataaacgc atattgattg
    13741 tcgacgatga tgtcgcactt agcaaatcaa ttaaagaggt acttatcagt cgggatttca
    13801 agaatatcag ctgtgcttat agtataagcg aaggaattga tatcttctca gtttctaaaa
    13861 ttgatctcat tattttagat gttatgctac cagatggaga agggcactta cttgcaaaat
    13921 acattaggaa atattcagat gtgccaattc tctttttaac agccaaaaac aatcctgatg
    13981 atgaaattcg aggacttgaa tccggagggg atgattatgt tacgaagcca tttcttccca
    14041 aatctttaac atatcgtatt attgcactgt tgagaagggc ttataaagat gaatcggaac
    14101 taattgagct aacaaattgt accatagact taaacaatgc aagtgttgaa aaaaatggtc
    14161 aacatttgtc actcactcca acagaaatac aaatcctacg aaaattattt tcaaataaaa
    14221 attatattgc atcaactgaa tcgatttgtg ataccgtttg gggacttgag agccttggct
    14281 acgaaaaatc acttatggta catattcgta atatcagaga aaaaatcgag ataactccat
    14341 ctaagccaaa tcatcttatt actgtaaaag ggcttggtta taaactagtt atataaacta
    14401 taaggaatat agcatgaata ttttcaagaa aaatatacta aaatttatcc tatcattttt
    14461 ctttattata ataattgacg tcatactgtt aataactgct accaattata tccgaagtca
    14521 gcagtctgca tctactataa tcgaaactgt ctcatctgaa atcactctat cttctaatgg
    14581 taaatataat gttagctcta aagctaaaca actcattgat gataaaaagt tatggataat
    14641 gattattgac aaagatagtg gaaaagaaaa atttaatatt aataaacctc agattataga
    14701 aaatcaattc gattttgcag atgctatacg attttctaga ttttacctaa aagactatcc
    14761 tgtatttacg caaataaaag ataatgatat ttacatcatt gcttttccaa aagacagtat
    14821 aatacgttat agtagtaatt atttcgaact aaatagagtt caaatttttc caatccttat
    14881 tttgtctatc atatttgcaa actgtttgtt ctgcctattt ctttacattt attctgttac
    14941 ttttttaaat cgtaacatta aacctatcat taacgcaatt actaaattac caaatggaat
    15001 taatactcag gtcaaatctg tacgagaatt agataaatta acacttgcta ttaactcagc
    15061 aaatcagcaa cttcgtgaaa acgaagaatt caaggagaat tggatttctg gaatagcaca
    15121 tgatataaag acaccacttt cagtaattgt atctaacact tccttagcca ttgaaaaaac
    15181 aaatgatgac gaattcctta aacatttgaa acccacctta gttgaaagtc actacattca
    15241 aaatctccta aacgatttaa atatatttgc tcgattaaca aacggaaact taaaactaaa
    15301 ccatgagatt gttgatataa tccctttctt caaagaaata atcattcaga ttatcaatca
    15361 agaaatttgg gaagacttca attttgaatt cattcctgat tctaaactat taggtaagaa
    15421 aatatatatt gaaaaagctc tcatttctag agttgttcat aacctaattt ataattcagt
    15481 acttcataat cattctggtt gcgacattaa aatcatttta gaatatctac ctgaagattg
    15541 tttttcgatt actattcgtg ataatggtat aggaacttct cctgaaagac taaaaaatat
    15601 caataagatt gaagaattta attttgatat gtcaggcgtt cgaaggagtg gtatgggatt
    15661 gaaaatttct aaacaaatta ttgatttaca tgatggaaac atgataatta caagtacaca
    15721 agggcagtac ttccaaacag taattaccct ccctattgaa tcactaaaca cttaacaaaa
    15781 tttttgatag agcagagatt aaaatccgaa acataagtaa aaaataatga ctttagcttt
    15841 ctgttattca gaatatttat tttttaggct ctttcttcac gattgcaaat attattatcg
    15901 gagataatat caactatgaa aaaatttgta aaaatcatta tttagtattt ggtgtgatag
    15961 acattactgc aaataaatca ctaagattta ttaaaaagca agtctattcc tatctagatg
    16021 atctctatca gtaagaggaa gttcaagagt attaagcatt tgaacaaatt cctcaagttc
    16081 actaaccttc ccctcgtatt catctagacg ttctgttaaa gaaatttgta actgttctat
    16141 ttctcgctct acttggtcaa ctttaatagt taatagaata ttcgtcttag tcaggttata
    16201 cctagctagc cttttaccct ctttattatc actttctaga ttgataaaca cttccgccat
    16261 cttgtttaag gtggcgattt tttcttggat ttcctctatc ttcatgtcta gtgtggctat
    16321 ttcttggacc agctggtcct tggtttcaag aaaggtttgg ttaggagtat gaatttccat
    16381 tagtagattt atcttttcaa ccttctcttt caatgtttca agtgttactc gttttcgata
    16441 tggaagtgaa tgtatactat aaaagtagac aaaactttgt gtgttacaat ctgttttaaa
    16501 agacacaaaa acgaaaggac aacctatgtc aacagttaaa cgctacgatg aagaattcaa
    16561 acaatctctt gtcaaccttt atcaaactgg aaaaactcag tctgaactct gtaaagacta
    16621 tggggtatcc gcttctgcgc ttgcaaaatg gatcaaacag tattcccaag tcaaactcga
    16681 agataattct gtacttactg ccaagcaaat acaagagcta caaaaacgta atgcgcagct
    16741 tgaagaggag aaccttatcc taaaaaaagc aagtgccata ttcatgcaaa acttaaagta
    16801 agactcctcg ctgtctatcg gttacgcttt gaacacgcca caacaacctt gtatcgtgtt
    16861 ttacgtgtca atcgctccac ttactataaa tttctaaaac ataagccctc caaaagagaa
    16921 ttggataatc aaatttataa aaaacaaata cttgagattt ataccaaagc gaacaaaaga
    16981 cttggtgtga agtctatcaa ggtcattctt taaagagact acgacacaaa aatctctgaa
    17041 ggaagaattt accgtcttat gaagaatatg gcgctcccta aaatggctac cgttaagcca
    17101 aaaacagctc ttaaaaggac tcaaaaaacg tatcctcaaa acttactcaa ccagaaattt
    17161 aatcctgaca aacctaatca agtatggtct actgacttca cctatatttc tattggatat
    17221 aagaaatatg tctatctctg cgcaatactt gatctctatt ctagaaaatg tattgcttgg
    17281 aaactgagtc atcgtatgga tgcaaagtta gcatgtgaca ctctagaatt agctcttaat
    17341 aaaagaaaga ttgaaggaac acttctcttt cattccgacc aagggtcaca atttaaggcc
    17401 agggaattga gaaaaataat tgatgacaac actatcatgc attctttttc taaacctgga
    17461 tatccttatg ataatgccgt aacggaagca tttttcaagt atttaaagca tagacaaatc
    17521 aaccgaaaaa aatatcaaaa tatcaaacag gttcaattag actgctttga atacattgag
    17581 aatttttata acaattacaa cccacatacg gctaatctag gactaacccc taatcagaaa
    17641 gaagaaaatt agtttaacgt aataaaataa cacggttttc tgtctactta tttgacatta
    17701 gtccaaaata catcctaatg gtgtcgcttt ttttatttca ctagacattc gttctagttt
    17761 aggatataag aaggtctcaa tttttttcat gatgtttatt ccaaacatcc aatcaccttt
    17821 ctatataact gttcatttag tggtatagac aaacagaaat actccgtttc tagtttcata
    17881 gaagacggag tattttttag tagagacgtc tggattgata gatagttggt atatagctca
    17941 tccctactag gctttcatta tagactatga tgggtttcgt tgacaacaat atgtgattat
    18001 tattctaaat gacagtatac atcaactatc aagtatgctt ttaattttat tttttaaagc
    18061 tacagatgaa aatctgtatt ccatacttcc atctaatcga acaataatat aatgatgtct
    18121 cgaatataat tcatgtttaa aaaacttttt gattttttta taaggaaact caaaaacaga
    18181 acaatgatac ccacttaatt tatttgctaa ttcaagacaa ttcttataga ttttcacatc
    18241 tattttttca actaatatca ttattctatc ttcaatttca tactcaattt cttgtgataa
    18301 aacagtggtt cctattccca tgcaaactcc taatacgttt actttattaa atttagaaac
    18361 catatcatca attctaccac catcagcaat atcaaatatg tcacctgact tagttcgtat
    18421 gaagatttta tagttcatac ttgaataatg tcctgttccg tataaattag ataatgaaaa
    18481 gtaaatgcaa tctgctggta aaaagttttt tacatactca tacaagacta aaacttttat
    18541 aaattcctgt ttcaccagtt tgttacttat ttttgaaata agactaatta agagttccat
    18601 atttattttg tctttttcat aaagacattt tatgatttct atgtcattat tacacaaata
    18661 tttacccaat attgcttcaa ttgaaatatc ttcaaatctt aactttttag ataaatcttt
    18721 ctccaaaaca tcaaatatat ttttgttaga cagttgaata aattctactt taattccttt
    18781 aaatcgttgc aagcctcgcc aagttgcaac tattatttct gcatccacat aagctgattc
    18841 tattccccat gcacctaata atatttgatt aaattgtctt ctataacctt tatatgtagg
    18901 aattctatct ctaaataaca ctccctcttg aatccacttt acaggtattt gttgtggtaa
    18961 gttagctata caacgcgaca tactaagtgc caaatctgat tggagggcgt atactgactc
    19021 tccttttact ctatgaactt caaatatttt tgtataatga acatcggttg catctaatta
    19081 ttttttctac ttcttcctca aaaacatcat agaaacccgt taatttactt tctctattgt
    19141 tcatatacca cctcttttag cttaaactca acgtaatttt accaccaata ggcattaaac
    19201 agctaggatg agtatgacca caatcaaaat tcaataaaat aggaatcttt ctatgcccta
    19261 caaattcatt aatgatatca ttaataacat cgctattttc ccctattgtt tcaaattttg
    19321 aaataataag tcctcctatt ttatcaaaaa taccatgtaa ggcaagcgtt gtgaaattcc
    19381 tatatagtct tcctagatcc gtatatacat cttctaacaa gagtatggta tcctctgtta
    19441 tttttggcat atactcagtt cctattattc ctacaatggt atcgagattt cctccgatca
    19501 aagtaccatt aaattcacct ttgttaaaaa taatccactc atttttattt gtttttttgg
    19561 ttctttcata ggtttcccaa tttatccact catccgtcca aacatctggt atttgtacca
    19621 ttaaggtttc gcacttactc tgaagcatga agtcaaaata gaaataattt aattcattaa
    19681 acggttcaaa ctctccaaaa ttagagataa cgctctgaga caggtaagtt atacatccag
    19741 tctttttata taaggctaaa gcaagagctg ttgtgtcaga atatccaata aagataggag
    19801 atttctgttt aaatagatcg tagtctatat actttaatac agaattagaa ttgtagccac
    19861 ctatggaagt catgatgaca tccacacgcg gaataagttg atttaattct tcagctctgt
    19921 cttgaactcc tcctgaaatt tcccctctat aaccttcttt tcctgttaaa tttccctcta
    19981 ctatagtaaa tcctttattt tgtaaaaatt ctactcctct cttatatcgt ttctgataat
    20041 gaaatgtccc cggataggag ggtgaacaaa tacctataga tttgatgttt ctttcactat
    20101 ttactctatt gacaatgatt ttaatatttc tttcatctcc ttttctagca cagcgtattc
    20161 cttgttttcc aaacagacat atcctactct ctcattactc caattaatcg gatttggcaa
    20221 tacagttcct tcctttttat atatcttttc ttcaaatatt agtgaagttt taggtgcatc
    20281 gtaactcact ccattaaata tttttccgta attctctgga ttgagtctga aaaatacaat
    20341 tcctgaaaac ttattagtgt ctgtatttaa ctcttcttgt aaacctagtc tagcttttaa
    20401 ataagtatta taaaaatcaa atcccttgac tataaagctg tttttcatta agtttggaat
    20461 acaatctcca ccgattcttg ctccaatttc tattaaaata atatctccat ttcttccaat
    20521 tctaaattct gtatgagtcg taatatgatt taattgcaaa atttgatgta atttttctgc
    20581 ccaagaatat actctacttt tttcttcttt gtttaaattt gaagggaaaa tatggcctat
    20641 ttcatccata aataattttt catccactat ttttttagtt atccctagag gtgtatagat
    20701 tccatttctt accacgctct ctaagctata ttcttctcca tcaataaact cttccaccaa
    20761 aactctaggt tctaaattat ataattcccc caattcatat acccctgaag ctatgtaaac
    20821 cggaaatttt acattaagca tttgagaaac tgcttgttgt aattctgaaa aattataaac
    20881 ttttttcact cctatacttg ctaaaaaaga ggttggtttc actattaatg gatatttcca
    20941 attgattatt ttatttgtat ctgaaaattg attgataatt ttatatttgg gcatttttag
    21001 tccaccagct tcacatacca ttctcattcg atctttaaac ctgaatgatt gagaatctag
    21061 cgatgaaata gggttcaatc ctaattcttt tgaaatatca tcagctatat gcgttaaagc
    21121 ttcatcccaa caagcaacag catcaataga atatttgagc tctttaattt gttcaatcgt
    21181 ctttccaaaa tttctaaagc tggtttcaat tgtttctaca aacaactctg gatacatcgt
    21241 aggaatttct gatactgaaa agaaattata ctccgtacta ttgttaatta aatcataaca
    21301 tatagttatc tctggacctc cacctacaat taaaatattc tttttcattt ttcttcctcc
    21361 tttatggtaa ataatcaatc ccattttctc tactgattaa ttgaactttt cgaacatcat
    21421 cgcacttcaa tatccacgct attaaacgct ctactcctaa accaaatcct gaagatttca
    21481 taggtcttgt ttttttcatt tctaaatacc aactatattc agaagcatct acttgtaaat
    21541 aattcatatt ttctacaact tcttcatatg tttcgcatct ttctccacaa cctacagttt
    21601 cgcctattcc taacaacaaa tctgcattat aggcaaatag atgatctgtt gagaaccttt
    21661 gataaaaagg gacactttta cagggataat tttttaccca aactactccc tcaaaatgtt
    21721 ccattaattt cttttcccca acatctgtta acacataaaa atgatgttca tcattatatt
    21781 ccaatgaatc tatttcattt tccaatatag tacaagcctc ttcaaacgta ataattggta
    21841 tctttcgatc aataaaactt tccaaatgac ttacatcttt tgttatagca aaaatactat
    21901 ctcgacactc tctaagaatt tcactaacca gaaacttaat atatctatcc actaaattca
    21961 tcacatagtg taaatctccc tctatctcac actcactatg ataaaattgc gataaatgtc
    22021 gatgatctac tgcttctcct ctaaaagtag gcattaagta atgaactcct gactttggaa
    22081 aaagtctaag tatatactct aagtgaaact gcatcgaatc tgcaagatag gtatcaacat
    22141 caaataagga aatttttaca ggtagcgaat cactccccaa ccccatagga cttgtgattg
    22201 acgatgttgt tatcggtaaa tgtactgttg aaattccttc atttttaaaa aatgtgattc
    22261 atcataggga gttagcgtta aaatttcttc ataagcttca taagcgtttt ttacttctct
    22321 tatctcacgg gggttcccta acactctttt cccatcaata atggctgtta tttgttctac
    22381 tgttaaagaa ttttgttcaa tagcgagtga tgagtgaata gactgaatac gattttcttt
    22441 tcttaatttt aaatctttct gtacttgtaa ttctaaatta ccaataattt tagaaatctc
    22501 tactacctta tttaacatgg tattcgtaac tgtaaaaggt ggtttcatca ttttctcctt
    22561 acaatctttt ttcttattta taccataaaa ataaatttat cgctcgttct tcaagcgata
    22621 aaacaagcga taaactatta caatttattt taaattcttt aacgattact aactttttaa
    22681 cgttattatt ttcaaatact ctacataaaa ttaccctaga gtattaaaac tcccactcaa
    22741 actcctagtc cctttgtttc aagctattta gaacttttat tgta
//
