LOCUS       NZ_CAAHKK010000012     18583 bp    DNA     linear   CON 11-MAY-2024
DEFINITION  Streptococcus pyogenes strain A920, whole genome shotgun sequence.
ACCESSION   NZ_CAAHKK010000012
VERSION     NZ_CAAHKK010000012.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (03-APR-2019) WTSI, Pathogen Informatics, Wellcome Trust
            Sanger Institute, CB10 1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900983635.1-RS_2024_05_11
            Annotation Date                   :: 05/11/2024 02:49:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,709
            CDSs (total)                      :: 1,652
            Genes (coding)                    :: 1,595
            CDSs (with protein)               :: 1,595
            Genes (RNA)                       :: 57
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 48
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 36 of 57
            Pseudo Genes (incomplete)         :: 21 of 57
            Pseudo Genes (internal stop)      :: 23 of 57
            Pseudo Genes (multiple problems)  :: 19 of 57
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:58:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 61343
            Orig. end                         :: 79926
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CAAHKK010000012.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..18583
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..18583
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..18583
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:14061](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14061
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    1466..1601
                     /db_xref="RFAM:RF00557"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00557"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="ribosomal protein L10 leader region; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
     gene            1630..2130
                     /gene="rplJ"
                     /locus_tag="E9649_RS06935"
                     /old_locus_tag="SAMEA3919117_01356"
     CDS             1630..2130
                     /GO_component="GO:0015934 - large ribosomal subunit
                     [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rplJ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012658294.1"
                     /locus_tag="E9649_RS06935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01356"
                     /product="50S ribosomal protein L10"
                     /protein_id="WP_002984821.1"
                     /transl_table=11
                     /translation="MSEAIIAKKAEQVELIAEKMKAAASIVVVDSRGLTVDQDTVLRRS
                     LRESGVEFKVIKNSILTRAAEKAGLDELKDVFVGPSAVAFSNEDVIAPAKVINDFTKTA
                     DALEIKGGAIEGAVSSKEEIQALATLPNREGMLSMLLSVLQAPVRNVAYAVKAVAENKE
                     GAA"
     gene            2195..2560
                     /gene="rplL"
                     /locus_tag="E9649_RS06940"
     CDS             2195..2560
                     /GO_component="GO:0000315 - organellar large ribosomal
                     subunit [Evidence IEA]"
                     /GO_component="GO:0022625 - cytosolic large ribosomal
                     subunit [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rplL"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018371186.1"
                     /locus_tag="E9649_RS06940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="50S ribosomal protein L7/L12"
                     /protein_id="WP_002984819.1"
                     /transl_table=11
                     /translation="MALNIENIIAEIKEASILELNDLVKAIEEEFGVTAAAPVAAAAAG
                     GAEEAAKDSFDVELTSAGDKKVGVIKAVREITGLGLKEAKGLVDGAPANVKEGVAAAEA
                     EEIKAKLEEAGATITLK"
     gene            <2858..3478
                     /locus_tag="E9649_RS08910"
                     /pseudo=""
     CDS             <2858..3478
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017648301.1"
                     /locus_tag="E9649_RS08910"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="replication initiator protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="AIYLIYSNSK"
     gene            3658..5471
                     /locus_tag="E9649_RS09055"
                     /pseudo=""
     CDS             3658..5471
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000237146.1,RefSeq:WP_001871971.1"
                     /locus_tag="E9649_RS09055"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="SAG1250 family conjugative relaxase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKFLDLFAGIGGFRLGLINQCHECIGFCEIDKFARQSYKAIYETE
                     GEIEFHDIRQVTDQDFRQLRGQVDIICGGFSLVKHFHSQADDWDLRALGELSSLRLLER
                     LIQTKIIFIITS"
     gene            5622..6308
                     /locus_tag="E9649_RS06970"
                     /old_locus_tag="SAMEA3919117_01364"
     CDS             5622..6308
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018373772.1"
                     /locus_tag="E9649_RS06970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01364"
                     /product="response regulator transcription factor"
                     /protein_id="WP_111686267.1"
                     /transl_table=11
                     /translation="MYKILAIDDDKEILKLMKTALEIENYHVITCQEIELPIVFEDFKG
                     YDLILLDIMMPNISGTEFCYKIREEVHSPIIFVSALDGDNEIVQALNIGGDDFIVKPFS
                     LKQFVAKVNSHLKREERAKIKNEAEERVKRSFPPIEIYLEERMLYIDKQPLFLTYREYE
                     ILELLSRHPYKVFTKEEIYEQVYSDEASALFHSISEYIYQIRMKFSSFGINPIKTIRGI
                     GYKWDV"
     gene            6301..7647
                     /locus_tag="E9649_RS06975"
                     /old_locus_tag="SAMEA3919117_01365"
     CDS             6301..7647
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984805.1"
                     /locus_tag="E9649_RS06975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01365"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_002984805.1"
                     /transl_table=11
                     /translation="MFKKYSIKNRVWRAVVEIVFGVCITVLMIAIISLSFSKLNIVTSH
                     NVGEEFYIKDKQSIKQLNNYMKTLGLDYVVFDRKTDKAMEGKYLSKEFSLFNEVAEEKN
                     NLTFNSVHYDLYTNINYNIVIRYNEIPEFSNHYLRNVSYNMLTFYILGIGTSISIVVAL
                     TRFVKEISLNFKEIKKLANKMGIEVLSENENYSKIIEFDDILRTLHIKGDNLKSLIERE
                     ILEKQDLSFQIAALSHDIKTPLTVLKGNLELLELTTLNKNQEGYIVSMNNSISVFEGYF
                     NSLISYTRMLSEDRSVKLILVEELLSELHFEVDDLLNINNIEFSICNRLIITSFYGDEE
                     NLIRALSNLLVNAIRFMPVLDKKIEVILSESGEQIHFEIWNNGERFSDSTLKKGDKLFY
                     TEDYSRGNKHYGIGLAFVKGVAIKHGGNLQLNNPARGGASAIISIKKKI"
     gene            7804..7944
                     /locus_tag="E9649_RS06980"
                     /old_locus_tag="SAMEA3919117_01366"
     CDS             7804..7944
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528609.1"
                     /locus_tag="E9649_RS06980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01366"
                     /product="lantibiotic streptin"
                     /protein_id="WP_002984803.1"
                     /sec_met_domain="TIGR03731 (E-value: 3.3e-10, bitscore:
                     32.1, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNTIKDFDLDLKTNKKDTATPYVGSRYLCTPGSCWKLVCFTTTV
                     K"
     gene            8059..9849
                     /locus_tag="E9649_RS06985"
                     /old_locus_tag="SAMEA3919117_01367"
     CDS             8059..9849
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019418808.1"
                     /locus_tag="E9649_RS06985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01367"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_011284758.1"
                     /transl_table=11
                     /translation="MIKAQLKNLIKTIHLVKEAGFSLLVFSIAISLFQGILPIFSMLLV
                     QKMLNIITTDIKNFHTLMIAFISYIALTLLTIIIGEVDSYIDTKLQILLHYKMNHLVMQ
                     KTVKLTLAEFETPEIYDDITRIQNQISYKPFQIYKSIISVLSSLVSLISSFVILLNWKI
                     SIFPLLLILPIVSIYIYLKIGKNEFEILYKRSSDERANWYISHLLTHDFAVKELRLGTL
                     ESYFLKKYDKNNQLFINQENSINRSKMKYGIVLGVLEIAIQSIIMFLAVREAFLGILLV
                     GNVTTFIRSLSTMQTSTQNIVNNIYSFYNGSLYMELLYDFTHDELVHNPIIESTVDTIQ
                     SVEFERVSFSYNGKDNVINDISFSIKAGERLAIVGENGSGKSTIFKLACGLYDNYEGNI
                     YINGINLRSIQKKSYYKRISALFQDFLKYELTLRENVGLGELSKLYSDEDLISALKYTG
                     VDSIFYFNQEKLNQIDLEQQLGNWFEDGRQLSGGQWQKIALSRVYLKEADCYLLDEPSS
                     ALDPESETKIFKTFFELSQNKIGIFITHKPSITQSVNKILYLDNGCIAETGSFADLNIK
                     GMKFKNLLDKEIGATYDTSN"
     gene            10001..11076
                     /locus_tag="E9649_RS06990"
                     /pseudo=""
     CDS             10001..11076
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="E9649_RS06990"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /pseudo=""
                     /sec_met_domain="LANC_like (E-value: 2.3e-23, bitscore:
                     74.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYSSLYKVTKDERYLTFSNIYVEKLVDIISRDGIESPSLYAGTAG
                     IALAIKEASISGKYYPKLLSSLNCLLKEQIKDKLVVSFSNIEKGIIEPYDYDMVNGFSG
                     ITNYLLLEQEFFL"
     gene            11095..14061
                     /locus_tag="E9649_RS06995"
                     /old_locus_tag="SAMEA3919117_01370"
     CDS             11095..14061
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528611.1"
                     /locus_tag="E9649_RS06995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01370"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_168389180.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.7e-91, bitscore:
                     299.4, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 6.4e-13,
                     bitscore: 41.5, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 7e-15, bitscore:
                     47.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYKVFPTGMIRIPLQKQEFYNKDYEDLINDKVFMEQLLVASPSLY
                     DSVIDFDKCNEKKKQNVKVSLNSYSKRAAFRTTPFGIFTAINTVDLTKGTTSNVQKVSF
                     IKKAVPDYSWIYSLVKSYEISNLEKLSLKINTAAFTQGDRYVLPFTVNESEEDRNISFS
                     KPIKLLVEKCKTRYIKYEELIDVFKNNYPDIVSDMLESYIHDLVTNDFLISDLRPPICN
                     INSLDYLLSKLEEGTLCTDLTTLKKMIEDYNDLNIGEGRDLLLQIFDKMESIYKYDNGG
                     NYLKVDSLAEYEGGFNILSETARESIERLAEMFVKLNTNVKRRGGRKNSLEEYQLKFIG
                     KYGENCSIPFVEVINKDAGIGFPEYYKGGEGEAIELSDPIMQMFEKKYEEALLNGGHIE
                     FYSKDLDDFQTDQSNSLDSFELNFNIKIINNDVKLYLGANIGSGQAGRSFGRFYGLSET
                     VRETIKNLNHQNNTNVELSFVPKQIRLANVIQNYSDESYNTSFFTTSWDSENELRLEDI
                     YIRYSDGKFHFTTIDGKNELNFTMNNMLNSDSQSRVLRLLVDLSEFEYGLSHWSLFPWD
                     ILAQERVYIPEILFEDITITTAQWNLSAIREEIIHQKIFTGKKDIFNKFRKTYKIPKDI
                     ILKYADNELRLDLSIDSDLEILFKNINKYRFVSLRGIEQGESIFKDNLGNYNTEIVVPI
                     LKESNGINNTNDNVQFKNEVKKIYLPFCDWLFFKFYGPKERQEELLNNWKKFWLNLPSE
                     LFSQSNMFYMRYNDTNDHIRIRINCDSIENNFSLYLSVVQDLLPQLIESCIISDIEVSS
                     YKPEVNRYGGPHLISYAEEIFCKESILFLNNTIEFSDDERLVCATYLVLYYLNHFFKDK
                     ETRRSFLFENYTGKYKKDFKNLPIDLPIEYMKILNGVTSALDRYDFFQEMDRYLMSYMK
                     EYNRFGGTNDIYNTKFNLVGSFLHLSMNRLNGIDREFEEKVYCFAYYTLNAQQYIEWE"
     aSDomain        11497..11751
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_E9649_RS06995_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="2.60E-13"
                     /identifier="RREFam001.1"
                     /label="E9649_RS06995"
                     /locus_tag="E9649_RS06995"
                     /protein_end="219"
                     /protein_start="134"
                     /score="41.5"
                     /tool="antismash"
                     /translation="NTAAFTQGDRYVLPFTVNESEEDRNISFSKPIKLLVEKCKTRYIK
                     YEELIDVFKNNYPDIVSDMLESYIHDLVTNDFLISDLRPP"
     gene            14067..14756
                     /locus_tag="E9649_RS07000"
                     /old_locus_tag="SAMEA3919117_01371"
     CDS             14067..14756
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922274.1"
                     /locus_tag="E9649_RS07000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01371"
                     /product="lantibiotic protection ABC transporter
                     ATP-binding protein"
                     /protein_id="WP_019418719.1"
                     /transl_table=11
                     /translation="MLKIQNLKKSYGKRTILNNVNMNIPKGKVYALIGPNGAGKSTIMK
                     ILTGLVSKTSGSIIFEGREWSRRDLRKIGSIIEEPPLYKNLSAYDNMKVVTTMLGVSES
                     AILPLLNKVGLGNIDKRPVKQFSLGMKQRLGIAISLINSPKLLILDEPTNGLDPIGIQE
                     LREIIESFKSEGMTIMISSHILSEVEHLADFIGFIYEGKIVLEKEYDGSENLEELFNNQ
                     ILFEKRR"
     gene            14762..15511
                     /locus_tag="E9649_RS07005"
                     /old_locus_tag="SAMEA3919117_01372"
     CDS             14762..15511
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984791.1"
                     /locus_tag="E9649_RS07005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01372"
                     /product="lantibiotic immunity ABC transporter MutE/EpiE
                     family permease subunit"
                     /protein_id="WP_002989889.1"
                     /transl_table=11
                     /translation="MVQIFLSNLFKIKNTSISKLILIFPIICVMLSLLFSALGGESILR
                     LAAETTVNQWGVIWINVIIAVNSGLLNKLELDSNKYSVFLSRDVDLKKVEYARVLLIAL
                     INLIISMILSLMLIVISFVLPTPSLISIGRILLTILLIWLTTLWQIPFILWLSRKINVY
                     FAMIINIISPLIIGTSFSLLNKWYLFPYDWSLKLLEPMTRMRINSIPFGAEFVPDYSQI
                     FISLFLGIAFFILLTNLFAISFKKQVK"
     gene            15514..16236
                     /locus_tag="E9649_RS07010"
                     /old_locus_tag="SAMEA3919117_01373"
     CDS             15514..16236
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922276.1"
                     /locus_tag="E9649_RS07010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01373"
                     /product="lantibiotic immunity ABC transporter MutG family
                     permease subunit"
                     /protein_id="WP_002989886.1"
                     /transl_table=11
                     /translation="MKSYLCSNFLKIKNTSYLLIHILAALLFPLLLFFYWSQRGGLQSR
                     TVLFSYFQIVGVLLPFVASIVCIQLKNLEESSGKYKYLLGYSQSNYKPFIVELVFLWLC
                     YCIVLIISITIFILLLKTIGINVSLRLLILNSLIYIIFAYVTYLINHIISYIFSTGVAL
                     GISMVGVIVAAFCETSLGDKVWFLIPWAWLLRISDTLYNQQKMAIVPLIVIFFVSCTVA
                     LLHIRIFKSWNQDCLTSS"
     gene            16427..16645
                     /locus_tag="E9649_RS07015"
                     /old_locus_tag="SAMEA3919117_01374"
     CDS             16427..16645
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984785.1"
                     /locus_tag="E9649_RS07015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01374"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_002989884.1"
                     /transl_table=11
                     /translation="MYPRIRNLREDNDFTQKFVANLLSFSHANYAKIERGEVALMADVL
                     VQFSKLYNVSIDYLLGQTDYPYRFHNK"
     misc_feature    complement(16457..16468)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.71"
                     /tool="antismash"
     gene            complement(16716..16859)
                     /locus_tag="E9649_RS08925"
     CDS             complement(16716..16859)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003042734.1"
                     /locus_tag="E9649_RS08925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_021299391.1"
                     /transl_table=11
                     /translation="MGISPTGLLRWQPERSEVSLSLFVVMADREPLYFIANNYRSYHGV
                     SH"
     misc_feature    complement(16917..16932)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.55"
                     /tool="antismash"
     gene            16946..17212
                     /locus_tag="E9649_RS07025"
                     /pseudo=""
     CDS             16946..17212
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001828144.1"
                     /locus_tag="E9649_RS07025"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="DUF3173 family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNIGFLEHTARNIIREAKRIAIKKLKKLANLNKMRYN"
     gene            17169..18356
                     /locus_tag="E9649_RS09060"
                     /pseudo=""
     CDS             17169..18356
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002943304.1"
                     /locus_tag="E9649_RS09060"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="site-specific integrase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTIKNQKKYKGVYCDKNGKIFYQADLGVDPVTGKRVQKKARKN"
ORIGIN
        1 cccaagttct ggttaaatca acctgtagta aatcaactgg catgccaagc gccaagccgt
       61 cattgacagc ttctaaactc tggactgcct tttcaatcaa agaaatgtgg cgggcatttg
      121 acaggtaagt ggcatcttgt tctactagtc cagcattatc aaagaagagc tggttgatac
      181 gatcttcgat cagattaatg ttctggttgg ttaacaccga aataggaata aggtccgctg
      241 gcaactgttc caattcaatc ttttgttcca aatctgtttt attcagcaat ataatgcggt
      301 tactgtcttg actgagattt aacaaagccc ggtcttggtc agtcagtttt tcagaagcat
      361 tcagcacaag aagaacaagg tcagcttctt gaagagcttt tttagaccgt tcaactccga
      421 tttgttcgac cagatcatct gtctcacgaa taccggccgt atcgacaagt tttagaggaa
      481 ctcccttgat attaacgtat tcttcaatga catctcgggt ggttcctgca atatcagtca
      541 caatagcctt gtcttctcgc aacaaattat taagtaagct tgacttaccg acgtttggac
      601 gaccaataat agctgttgat aagccctcac gcagaatttt accgcgttta gctgttcgaa
      661 ggagattttc caaaaggctt tggaattctt gtgttttctc acgtagcaga gcagtggtca
      721 tttcttccac atcgtcgtat tcagggtagt caatattgac ttcgacttga gctaaggtgt
      781 tgagaatttc ttgtcgggtg tcattgataa gctgggaaag ggagccatcc agttgcttga
      841 ctgcaatcgt catagccttg tctgttttgg cacgaataat gtccatgaca gcctcagctt
      901 gagtcaaatc aacacgacca tttaagaagg cacgtttggt gaattcgcca ggctctgcca
      961 ttctagcgcc ttggcgaatc aatagttgca agatttcatt tgtcacagca ataccaccgt
     1021 gcgtattgat ttcaaccaca ttttcacggg taaaggtttt gggagccagc atgactgaca
     1081 ccataacctc atcgacaata gttcctgtgt taggatcaat gatatggcca tagttaatgg
     1141 tgtgtgaagc tacttgctct aagttctttc ccttaaaaac agattgtgca atggcaagcg
     1201 catctgtccc ggatagacga acaatgccaa tagctccttc accaagaggg gttgaaatgg
     1261 cggtaattgt atcaaattct ttagttatac tcatgccctc tattttaaat caagtcctag
     1321 tagaaagcaa ggtattattt tgtatagaaa ataggactag caccattttg agtttagcta
     1381 atactaaaaa agaataaatg taaaaaaatc atttttttaa taatttttat tgacaatagt
     1441 attataaaag aatataatga tataggtttt gataaaaaac tgacctaaga cagcagggga
     1501 gcatgctcat aatattcctg ccgaggcaca aaacgtgatt aaagagaata acgtatttgt
     1561 actttcgtgt ctaggtttag gtgcgatttt tttgtaccta gcccaaaaat aaaaacggag
     1621 gtaaaactaa tgagtgaagc aattattgct aaaaaagctg aacaagtcga acttattgct
     1681 gagaaaatga aagcagcagc aagtatcgtt gttgttgatt cacgtggtct tacagttgat
     1741 caagatactg ttcttcgtcg ttcacttcgt gaaagtggcg ttgagttcaa agttatcaaa
     1801 aactcaattt tgactcgtgc agctgaaaaa gcaggtcttg atgagttgaa agatgtattc
     1861 gtaggaccat ctgcagtagc attttctaac gaagatgtta tcgcaccagc taaagttatc
     1921 aacgacttta ctaaaactgc tgacgcactt gaaatcaaag gtggtgcaat cgaaggcgct
     1981 gtttcttcaa aagaagaaat ccaagcactt gcaacattgc caaaccgcga aggaatgctt
     2041 tctatgcttc tttctgtact tcaagctcca gtccgcaacg ttgcatacgc tgtcaaagct
     2101 gttgcagaaa acaaagaagg cgctgcttaa gacgtctcag agtagcttaa ggctacgctt
     2161 aacattttaa attaattatt tggaggaaat cacaatggca ttgaacattg aaaacattat
     2221 tgctgaaatt aaagaagctt caatccttga gcttaacgat cttgtaaaag ctatcgaaga
     2281 agaatttggt gtaactgcag ctgctcctgt agctgctgca gctgctggtg gtgctgaaga
     2341 agctgctaaa gattcattcg acgttgaatt gacatctgct ggcgacaaaa aagttggcgt
     2401 tatcaaagct gttcgtgaaa tcacaggtct tggtcttaaa gaagctaaag gtcttgttga
     2461 tggagcacct gctaacgtta aagaaggcgt tgctgctgca gaagctgaag aaatcaaagc
     2521 taaacttgaa gaagctggag caacaatcac tcttaaataa gaagcagata gcaatttgag
     2581 agcgaaatcc cgatttatca gttttttaga gcttatagcg atttgaagaa actgataaaa
     2641 tgatttggtt tcttgccaaa aatcctgcca aaaatttttt ggcaggattt ttattttcta
     2701 taaaaattaa gctgagtaga gtggctattc tatttatatg tgtctagtaa taattttttt
     2761 atgtgaacga gaacatttta ataagtgttc tcgttttttt atgttcagga ggaaaatcat
     2821 gcaaatgaat gaacagtcat cacgacaaat ggtgattgcc atctatctca tttattccaa
     2881 ctcaaaatga tagtactcct tggctgttcc aagtcgaaat tgttagtgat taagaaaacc
     2941 tacgagacta tggtttgatc gatgaaggcc agcagtctcc cagtgaaaaa gggcgtttgg
     3001 ctaataagat ttatttagga aagttggaac atgattccac cccagtctta agttcagacg
     3061 ggggtagtct aaaaaaacac gggaccagtc tcaaaaacag acaagccccg tgttaaattc
     3121 agcccctagt gagactgaaa agagtgaaac tgaaggtagt gaaactaaag agagtaattt
     3181 agtcattgag gacgaggagg aaagaaagga gtgcactagt gtgaaaaaga ctgagggtca
     3241 ctttacccgt caagttgatc aggtcaccaa atatgacaaa gattatattt ggagtttggt
     3301 tcattcccaa ttacgtgaag gtggtttatc acaagctgct agtgacttag tcatgagcta
     3361 ttttgaagaa cgctatgctt atgcgctgga acacatacgg ttcgcaagaa cagctgaagc
     3421 tattgcggaa tatgtcttta atggtgtctt atccgaatgg accaagcaac taaggtgaca
     3481 agaagcgaag tgaggtgagt aagatgtttt ggtggctatt attaggtgtt tggggtctaa
     3541 ggacaatttg gttgattatt gaagttatca ctgcaccaga aatggaagat tatagttgag
     3601 taaggacgtt acataagcag taaggtcctt ttattttgtc agaaaggaat gagagatatg
     3661 aagtttttag atttgtttgc aggaattgga ggctttcgat tgggtttaat taatcagtgc
     3721 catgagtgta ttggcttttg tgagattgat aagtttgcga ggcaatctta caaagccatc
     3781 tatgagaccg aaggagaaat agaatttcat gacattagac aagtcacaga ccaagacttt
     3841 agacaactta gagggcaagt ggatatcatc tgcggtggtt tttcccttgt caagcatttt
     3901 cactcgcagg cagacgactg ggatttgagg gcactaggag aactctcttc tttgagatta
     3961 ctcgagcgac tcatacagac aaagatcata ttcataatca catcttaatc aacgccattg
     4021 actgtaattc agataaaaag ttgatatgga attatgcctt ggaacgaaac cttcgtatga
     4081 tttcagaccg catttctaaa atggctgggg cgaaaattat tgaaaagcat ttctcttacc
     4141 gtgactatca aaaatataga gcgactagtc ataagtttga actaaagcaa cgtctttatt
     4201 ttttgatgca gcagtcaaag ttctttgatg atttttttag aaaaagcaga gtaattacat
     4261 gttcatattg attttagtca gaagcatagc agattcatga tgacggatcg agtaatgaaa
     4321 aaaccaattc gaggtcgtca actcagtaaa cgagatttat atgatgaaga attttttcgt
     4381 acacattttg ccaagataga aattgaaagt cgattaaaat ttttgtttaa ccgtgccaat
     4441 tcattagagg agctactatt aaaagcaaaa gaagtgaatc taaccattga cttaaaacaa
     4501 aaaatgtaac ttttatccta gaagaagata ctcaaaagat aagtttaggt cataaaaaaa
     4561 taagcgataa gaaattatat gatgtcaatt ttttcaagat tactttaaaa ataaggaagt
     4621 cggtgtttca gatcgattag aaagtctaca gaaacagtac atgcttttca agaagaatga
     4681 gataaagagg aggtatccac tgaagagagt aaggaagtct tcaagaaata caaggggcaa
     4741 cgagatgcca tccatgagtt tgaagttgaa cttgtggaac atcaaattga gaggttaatt
     4801 gctgaggaca tttatatcaa ggtgtctttt ggtgtaaagc agagtggtct tattttcatt
     4861 cctaactatc aattggatat taggaaagaa gaaaatcata aaaaatataa agtctatatt
     4921 cgtgagaccg cacaattctt catttacaac aaggaggcgt ctaaacttaa tcgctatgtg
     4981 cgagggcgtg agctcattta ccagttaacc aatgatagca agagtattcc aaaaagaaga
     5041 cgaccaaaac cattgataca cttaagaaaa agattgaaga aataagtctc ctcattgagt
     5101 tagatacgga gaataagcct tatcaagata ttaaagatga cattgttaaa gatatggctc
     5161 aattagattt gaccattaca gagttgcagg accatattgc tcatctcaat aaggttgcgg
     5221 aggtcttgct taatctgaac aacaacgata tagagaaccg ccgtttggcc agatatgact
     5281 atgccaagat gaacttgact gcagctataa aaatagaaga agttgagaaa gagattgaaa
     5341 cttctcaaaa tgaacttaat atatccatag atgagtatga atatctagta agaaggttgg
     5401 aaaagtttgg agagatcttg agtgatagca aaattatcga tacttctcga aatgaaatac
     5461 aatgggagta attatgatat aatttgggtg gtagcaattt ttatatcaga tattaaaatc
     5521 tagttgatgt ttcgtaaata actatattaa agaaatgatt cctgccgctt acattgagaa
     5581 tagtttattt ataagtattt cattatttaa aaggagtaat aatgtataag attttagcca
     5641 tagatgatga taaagaaatt ctgaagctta tgaagactgc tttggagatt gaaaattacc
     5701 atgttataac ctgtcaagag atagaattac caatagtttt tgaagatttt aaaggatatg
     5761 atttgatctt attggatatc atgatgccta atataagtgg aactgagttt tgttataaaa
     5821 ttcgggaaga agttcattct ccaattattt ttgttagtgc tttagatggc gataatgaaa
     5881 ttgtccaagc tttaaatata gggggagacg attttattgt gaaaccattt agcttaaaac
     5941 aattcgtagc taaagttaac tctcatttga agagagaaga gagagcaaag ataaagaatg
     6001 aggctgagga gagagtgaag cgaagttttc cacctataga aatctatcta gaggaacgta
     6061 tgttatatat tgataaacag ccgttattcc tgacttatag agagtacgaa attttagaat
     6121 tactgtcacg tcatccgtat aaagttttca caaaagaaga gatatatgaa caagtatata
     6181 gcgatgaagc ttcagcattg tttcattcta tttcagaata tatctatcag attagaatga
     6241 aattttcaag ttttggaatt aatccaataa aaactattcg cgggattggt tataaatggg
     6301 atgtttaaaa aatattcaat aaaaaatcgt gtttggcgcg ccgtcgttga aattgtcttt
     6361 ggagtttgta tcactgtttt aatgattgcg ataatatcgc tttctttttc aaagttaaat
     6421 atagtgacat ctcataatgt gggagaagaa ttttatatta aagataaaca gtcaatcaaa
     6481 cagttgaaca attatatgaa gacattggga ttagattatg ttgtttttga tagaaaaaca
     6541 gataaagcta tggaaggaaa atatttatct aaagaatttt ctttatttaa cgaagttgca
     6601 gaagaaaaaa ataatctgac ttttaattct gtacattatg atttatatac taatatcaat
     6661 tataatattg ttataagata taatgagata ccggagtttt ctaaccatta ccttagaaat
     6721 gtttcatata acatgttgac attttatatt ctgggaatag gaacgagtat cagcattgta
     6781 gttgctttaa cacggtttgt aaaagaaatt tctttgaatt tcaaggaaat caagaagtta
     6841 gcaaataaaa tggggataga agtcctttct gaaaatgaaa attattctaa aataatcgag
     6901 tttgatgata tacttagaac tttacatatt aaaggtgata atttgaaaag tttgattgag
     6961 cgagaaatat tggaaaagca agatctatcc tttcaaattg cagcactttc gcatgatata
     7021 aaaacacctt taacggtttt gaaaggaaat cttgagttat tagaattgac tactttaaat
     7081 aaaaatcagg aaggttatat tgtatctatg aacaacagta tttctgtttt tgaaggctat
     7141 ttcaattctt taatatctta tacacgcatg ctttcagagg atagatcagt gaaactaatt
     7201 ttagttgagg agctattaag tgagttacat tttgaagtcg atgacttatt gaatatcaat
     7261 aatattgaat tttctatttg taatagactt attatcactt ctttttatgg agatgaggaa
     7321 aatctgataa gagctctttc taacctttta gttaatgcaa taagatttat gcccgtatta
     7381 gataaaaaaa tcgaagttat actgtctgag tcaggagagc aaattcattt tgaaatatgg
     7441 aataatggtg agcgtttcag tgatagtaca ctgaaaaagg gagataaatt attttacacg
     7501 gaagattata gcagaggtaa caaacattat ggaatcggtt tggcatttgt taaaggcgtt
     7561 gctatcaaac acggtgggaa tcttcaattg aataatccag ctagaggagg tgctagcgcc
     7621 ataatctcga taaaaaagaa aatttaatag atttgattga aactggagta tttcaggcaa
     7681 aaaatcgtaa atttttgtga tttttggcta aaatactttt tttctgaaca aattctgaac
     7741 ttggggtgtc ataataatca tgtaaatata tcggatgcaa aaacgtaaga gaggaactag
     7801 aaaatgaata acacaattaa agactttgat ctcgatttga aaacaaataa aaaagacact
     7861 gctacacctt atgttggtag ccgttaccta tgtacccctg gttcttgttg gaaattagtt
     7921 tgctttacaa caactgttaa ataataaagt tatcattatc atcaacatta taatttcaaa
     7981 taatttgata tatttataaa tttaggggag tagactgatt ttagtttgct cctttattag
     8041 tagataagga agttatacat gattaaagct cagctaaaga atctaataaa aacaattcat
     8101 ctcgtaaaag aggctggttt ctccctactg gtgttctcaa ttgctattag cttatttcaa
     8161 gggattttac ccatttttag tatgctacta gttcaaaaaa tgttaaacat tataacgact
     8221 gatataaaaa attttcacac attgatgatt gcttttatct catatattgc tttaacatta
     8281 ttgacaatta taataggaga agttgatagt tatattgata ccaaattaca gatacttctt
     8341 cactataaga tgaaccattt agttatgcag aaaactgtaa agttaacatt ggctgaattt
     8401 gagacaccag aaatctatga tgatatcact cgcatacaaa atcaaatatc ttataaacct
     8461 tttcaaatat ataagtcaat tatttctgta ttatcttcgt tagtatcatt aatttcctca
     8521 tttgttattt tattaaattg gaagatatca atttttccac ttttacttat ccttcctatc
     8581 gtttctatat atatctactt gaaaattggt aaaaatgaat ttgagatact atataaaagg
     8641 agtagcgatg agagagcaaa ttggtatatt agtcatcttt taacacatga ttttgctgtc
     8701 aaggagttga ggttaggtac gttagaaagt tattttctaa aaaaatatga taaaaataat
     8761 caattattta ttaatcagga aaatagtata aatagatcta aaatgaaata cggcatagta
     8821 ttaggtgtat tggagattgc tatacaatct attattatgt tccttgcagt tagagaagca
     8881 tttctaggaa tattattagt tggaaatgta actactttta taaggtcttt atctacaatg
     8941 caaacaagta cacaaaatat agtaaataat atctattctt tctataatgg ttcattgtac
     9001 atggagttat tgtatgattt tacgcatgat gagttagtac ataaccctat aatcgaaagt
     9061 acggttgata caattcagtc agttgaattt gaaagggttt ctttttcata taatggtaag
     9121 gataatgtca taaacgatat aagtttttca attaaagcag gagagaggtt agcaattgtt
     9181 ggtgaaaatg gttctggaaa aagtacgatt ttcaaattag cctgcggtct ttacgataat
     9241 tatgaaggca atatatatat aaatggtatt aatcttcgtt caatacagaa aaagtcatac
     9301 tacaagagaa tatccgcatt gttccaagat tttttaaagt atgaattgac actgcgtgaa
     9361 aatgttggat tgggtgaatt atcaaagtta tatagtgatg aggatttaat aagtgcactg
     9421 aagtatacag gagttgattc gatattttac tttaatcagg aaaaattaaa tcagatagat
     9481 ctggaacagc aattagggaa ttggtttgag gatgggagac agttatctgg tggacagtgg
     9541 caaaaaattg cattatcaag agtatatctc aaagaagcgg attgctattt gctagatgag
     9601 cctagttctg cgttagatcc tgagtctgaa acaaaaattt ttaaaacatt ttttgaatta
     9661 tcgcaaaata aaattggtat ttttattacg cataagccaa gcattactca atctgtgaat
     9721 aaaattttgt atctagataa tggatgtata gctgaaacag gaagtttcgc tgatttaaat
     9781 attaaaggaa tgaagtttaa aaacttatta gataaagaaa ttggagccac atatgacacc
     9841 tcaaattaaa cagatagtag attacattgc agatagtttt ataaattatg aacagatagt
     9901 agctgaaagt gagaataaag tactaattaa tattgaatct aaatatagaa ataccttttt
     9961 tgataaatct ctgagtcatg gtgtgccatc attaatctta atgtatagtt cactatataa
    10021 agtgacaaaa gatgagagat atctaacatt ctccaacata tacgttgaga aattagtaga
    10081 cataatctct agagatggta tagaatctcc gtctctctat gctggcactg caggtattgc
    10141 attagctatt aaagaagcga gtatatctgg aaagtattat ccgaaattat tatcatcctt
    10201 aaattgtctt ctaaaagaac aaattaaaga caaattggta gtaagttttt ctaatattga
    10261 gaaaggaatt attgagccat atgattatga tatggttaac ggatttagtg gaataactaa
    10321 ttacttactc cttgaacaag aattttttct gtagagttaa atcaaattgg aaattatctt
    10381 ttgaaatata ttgagacaat tttaaataag gtaactaatt gttctgaaga tagagaagct
    10441 gaatttgatc taggaattgc acatggaatt actggtccta tgctaatcct agcaaaatta
    10501 aaatcagaaa aaattttgag tgtagaagta ggagatatac tgaataaagc tataaattta
    10561 atgtttttat ttagaaggga tgacaaacta tggcctggaa aaatttatac tagtaatatt
    10621 ttggatcttg atttaaatta tcttcctact agaatggcat ggtgttacgg tacgcctgga
    10681 actgcagttg ccctttttaa aatgtgtcaa ttgatagatt taaattttat tgacgatatt
    10741 aatgaaagtt taattgctca gatgagaagt tcagacaaaa atgtctattc tcttacaatg
    10801 tgccatggtt tggcaggagt aacttttata tatgacttga ttggtaaaaa ttattcaagt
    10861 gagaggctaa ctcgctttgc agaagagctt cgccaacaaa taattacatc gttttcaact
    10921 acaaaagtat ttgggtatac tgacagagaa aaatttggag aaatagaagt tgaactggag
    10981 tcaataggga tattgcaagg ggtatcaggg atagtgttat tcttattaaa tccttacagt
    11041 gacgaggagc tattgtggca aagaatattt atttaatttg aaaaggagaa caaaatgtat
    11101 aaggtatttc caactggtat gattcgtatt ccattgcaaa aacaagaatt ttataataaa
    11161 gactatgaag atttaataaa tgataaagtt tttatggaac aacttttagt tgctagtccc
    11221 agtctttatg atagtgtaat agattttgat aaatgtaatg aaaagaaaaa gcaaaatgta
    11281 aaagtctcat taaatagtta ttctaaaaga gcagcgttta gaactactcc atttggtatc
    11341 tttactgcta ttaatacagt tgatttgaca aagggaacca cttctaatgt acaaaaggtt
    11401 agttttatta aaaaagcagt cccagattat tcatggatat attctctagt aaaatcgtat
    11461 gaaataagta accttgaaaa actttcatta aaaataaata cagcggcgtt tactcaaggt
    11521 gacagatatg tactaccatt tacagtgaat gaatcagagg aagatagaaa cataagtttt
    11581 tcaaaaccaa ttaagttact tgtagaaaaa tgtaaaactc gatatataaa atatgaagag
    11641 ttaatagatg tatttaaaaa taattatcca gatatagtgt cagacatgct agagtcatat
    11701 atacacgact tagttacaaa tgatttttta atttcagatt taagaccacc aatttgtaat
    11761 atcaattcct tagattatct actatctaaa ttagaagaag gaacactatg tactgactta
    11821 actactttaa agaagatgat tgaagattac aacgatttaa atattgggga aggtagagac
    11881 ttacttttgc agatttttga taaaatggaa agtatttata aatatgataa cggtggaaat
    11941 tacttaaaag ttgattcatt agcagagtat gaaggcggtt ttaatattct atctgaaacg
    12001 gctcgggaaa gtatagaacg actcgcagag atgtttgtaa aattaaatac aaatgtaaag
    12061 agaagagggg ggaggaaaaa ttcacttgaa gagtatcagt tgaaatttat tggcaaatat
    12121 ggagaaaact gctcaattcc ttttgttgaa gtaataaata aagatgcagg cataggtttt
    12181 cctgaatatt acaaaggagg agaaggtgaa gcaatagagt taagcgatcc aataatgcaa
    12241 atgtttgaaa agaaatatga ggaagctcta ttaaatggag ggcatatcga attttattca
    12301 aaagatttag atgattttca aacagatcaa agcaatagtt tagattcgtt tgaattaaat
    12361 tttaatataa aaataataaa taatgatgtg aagttatatt taggagctaa tatcggttct
    12421 ggacaagcag gtagaagctt tggaagattc tatggattaa gcgaaacagt aagagaaaca
    12481 attaagaatt taaaccatca aaataatacg aatgtagagt tgtcatttgt tcctaaacag
    12541 ataagacttg cgaatgtaat tcaaaattat agtgatgagt cttataatac ttcatttttt
    12601 accacatcat gggattcaga gaacgaactg cgattggagg atatttatat aagatatagt
    12661 gatggtaagt ttcattttac aactatcgat gggaaaaatg agttgaattt taccatgaat
    12721 aatatgctaa attccgatag ccaaagcagg gttttgagat tgttggttga tttatctgag
    12781 tttgagtacg gtttatcgca ttggtcatta tttccttggg atattttggc tcaggaaaga
    12841 gtatatattc ctgaaatttt atttgaagac attacgatta ccactgctca gtggaattta
    12901 tcagcaatta gagaagagat tatacatcaa aaaatattta ctggtaaaaa agatatattc
    12961 aataagttta gaaagactta taagatacct aaagatatta ttttgaaata tgcagataat
    13021 gaattgaggt tagatttatc tatagatagt gatttagaga ttttatttaa aaacattaat
    13081 aaatataggt ttgtttcttt gagaggaatt gagcagggag agtctatttt taaggataat
    13141 ttagggaact acaatacaga gatagtagtt ccaattctta aggaatctaa tggaataaac
    13201 aatacaaacg ataatgttca atttaaaaat gaagttaaga aaatatattt accattttgt
    13261 gactggctat ttttcaaatt ttatggtcca aaagagcgac aagaagaatt actaaataac
    13321 tggaaaaaat tttggctaaa cctgccatca gaactgttta gccaaagtaa catgttttat
    13381 atgagatata atgataccaa tgatcatata agaattcgga taaattgtga ttcgattgaa
    13441 aataactttt ctttgtattt gtcagtagtt caagatctat tacctcaact gattgagagt
    13501 tgtattatct ctgacataga agtgagtagc tataaaccag aagtaaatag atatggagga
    13561 cctcatttaa taagttatgc agaggaaatt ttttgtaaag aatctatctt atttcttaat
    13621 aatacaatag aattttcaga tgatgaaaga ttagtttgtg ctacttactt ggttctatat
    13681 tatctaaatc actttttcaa agataaagaa acaaggcgct ctttcttatt tgagaattat
    13741 accggaaagt ataagaaaga tttcaaaaat ttgccaattg atttacctat tgagtatatg
    13801 aagattttga atggagtcac ctcagctctt gatagatatg attttttcca agaaatggat
    13861 agatatctca tgtcttatat gaaagagtat aatcgatttg gtggtacaaa tgatatctat
    13921 aatactaaat tcaatttagt aggaagtttt ttacatctat caatgaatcg attaaacggg
    13981 attgatagag agtttgaaga gaaagtgtat tgttttgctt actatacact aaacgctcag
    14041 caatatatag aatgggagta actaatatgt tgaaaataca aaatctaaaa aaatcttatg
    14101 gtaagagaac catattgaat aatgtcaata tgaatattcc taagggaaaa gtgtatgctt
    14161 taatcggtcc aaatggtgct ggaaaatcaa ctattatgaa aattttgaca ggcttagtta
    14221 gtaagacaag tggttctatt atttttgaag gtagagaatg gtcacgtcgg gatctgcgaa
    14281 aaatcgggag tattattgaa gaaccaccac tttataaaaa tttgagtgct tacgataata
    14341 tgaaggtagt tacaacaatg cttggtgttt cagaaagcgc tatacttcca ttattaaata
    14401 aagttggtct aggaaatatt gacaagagac cagtaaaaca attttctctt ggaatgaagc
    14461 aacggttagg tatagctatc tctttaataa attcgcctaa attacttata ttagacgaac
    14521 ctactaatgg cttggaccca attggaattc aagaattaag ggaaattata gagtcattta
    14581 aatcagaagg aatgacaatt atgatttcaa gccatatact gtcagaagtt gaacatctag
    14641 ctgattttat tggatttatc tatgaaggaa agattgttct ggaaaaagaa tatgacggct
    14701 ctgagaatct tgaagagtta ttcaataatc aaattttatt tgaaaagagg aggtaggggc
    14761 tatggtacaa atttttttat caaatttatt taaaataaaa aatacgagta ttagcaagtt
    14821 gattcttatt tttcctatta tttgtgtgat gttatcttta ttgttttcag cattaggtgg
    14881 tgaaagtatc ctacgtttag ctgcggaaac aacagtaaat cagtggggag ttatttggat
    14941 taatgttatt attgctgtaa attctggttt gttaaataaa ttagaattag attctaataa
    15001 gtattctgtt tttttatcaa gggatgttga tttaaaaaag gtagaatatg ccagagttct
    15061 attgatagct cttataaatc taataattag tatgatttta agcttaatgc ttattgtgat
    15121 tagttttgtc ctacctactc caagtcttat tagtataggt aggatactat taactatctt
    15181 gttaatttgg ttgactacac tatggcaaat cccgtttatt ttatggctat caagaaaaat
    15241 taatgtgtat tttgctatga ttattaatat tatatctcca ctaattattg gtacaagttt
    15301 ttctctctta aataaatggt atttgttccc ttatgattgg tcgttgaagt tgcttgagcc
    15361 aatgacaaga atgagaataa atagtatacc ttttggagcg gagtttgttc cagactactc
    15421 acagattttt atatcattgt tcctaggaat tgcttttttc atcttactga ccaatctatt
    15481 tgctatctct ttcaaaaaac aggtgaaata gtcatgaaat catatttatg ttctaatttt
    15541 ttaaaaatca aaaatacttc atatttacta atacatattt tagctgcact attatttccc
    15601 ttacttctat ttttctattg gagtcaacgt ggaggtttac aaagcaggac tgtattattt
    15661 tcctactttc aaatagtagg tgtacttctt ccttttgttg caagtattgt gtgcattcaa
    15721 ctaaaaaatt tggaagaatc atctggaaaa tataaatatt tattgggtta ctcacagtcg
    15781 aattataagc catttattgt agaattagta tttctatggt tatgctattg tatagtatta
    15841 attatttcaa ttactatatt tattctttta ttgaaaacta ttggtataaa tgtatctctc
    15901 agactactta ttttgaatag tttaatttat atcatttttg cctatgtaac ctatctgatc
    15961 aatcatatta ttagctatat atttagtaca ggtgtggcat taggtatttc aatggtaggt
    16021 gttattgttg cagctttttg tgaaacgagc cttggtgata aggtatggtt tcttattcca
    16081 tgggcatggc ttttaagaat atcagatact ctatataacc aacagaaaat ggcaattgtt
    16141 ccacttattg ttatattttt tgtttcatgc acagtagctt tacttcatat acgaatattt
    16201 aaaagttgga atcaagactg tttgacaagt agttaaatac atctattttg tttacctaac
    16261 aataaatatg atttttaagt tataaatact atctaacttg tttaactaaa aaatgactat
    16321 aaaatttcaa tggtttacta gcttatattt aatagacttg tccaaatagg acaattaaac
    16381 attttttaat caaatctcct ttatactgat attaggagaa tgttagatgt atccgcgtat
    16441 taggaatttg agagaagata acgatttcac tcaaaagttt gttgcaaatt tactttcctt
    16501 ctctcatgca aattatgcaa aaattgagag aggagaggtt gccttaatgg cagatgttct
    16561 tgtgcagttc tctaaactct ataacgtcag tattgattat ttattagggc aaacagatta
    16621 tccgtatcgt tttcataata aataaaagtc tcgccttgat ttgttcattg acaactgaat
    16681 aaaccgaggt gggactttct tgtttgtcga gcaatttagt gagatacgcc gtgataggag
    16741 cgataattat tagctataaa atagagtggt tctctatctg ccatgaccac aaatagggac
    16801 aatgatactt ctgaacgttc aggctgccag cgtaaaaggc cagtgggtga gattcccatg
    16861 agtgatttaa ccagtcatac ccacggaggt tgtaattttt ttgaaaggag tggaggtgtg
    16921 aaaatagtaa catataaaaa gcttgatgaa tattggtttt ctcgaacata ctgcaagaaa
    16981 tattattaga gaagcaaaaa gaatagctat aaaaaagttg aagaagctcg cgaacttgaa
    17041 caaaatgcgg tacaattaag taaatcgccc tttgacaata gaagacttgg tattgctcct
    17101 aaagatattg tagaagagtt agtaggtgtt ctactctctg aagaaagttt agaaagtgag
    17161 aattaaagat gactataaaa aatcaaaaaa agtacaaagg tgtttattgt gataagaatg
    17221 ggaagatatt ttatcaagct gatcttggtg tagatccagt aacaggtaaa cgagttcaaa
    17281 agaaagccag aaagaattag tatggaaagc catttggtac aatgaaagaa gcgtatgatg
    17341 aactggttcg gattaggtat gagttcagta ataatcttag tattgaaaat gacaatatat
    17401 cgtttgaaaa ctatatgaat actatttacc taagagcata taagcaaaag gttcaggctg
    17461 taacttatga aatagcctta ccacatcata agttatttat tcagtatttt ggttctaaac
    17521 ttttaaaggg aataacagct tgagattgtg aatcttttag tttacatatt attgaaaatt
    17581 atgcaaagaa tttatggtcg cgattcaaag cttgcatggg gtatgctgaa aggttagact
    17641 atatttcaaa agtgccatgt aaggctttgg ataatcctaa agggaaacat cccgacactc
    17701 cattttggac ttatattgag tttcagaatt ttataaaatc gtttgatttg caagattatg
    17761 aagagctaca aagatttaca actatttggc tatattatat gacaggtgtt cgtgtaagtg
    17821 aaggtttatc attatgatgg gaaaatatcg atttcgaaca aaaattcttg aaagttcata
    17881 caaccttgga aaaggatgaa aatggaaatt ggtatcgtaa agaccaaaca aaaacgccag
    17941 caggagaacg tcttattgag ttagatgatg tgacaatagt attattggaa aattggagaa
    18001 gaaatcaagt agtcaatact gacacagatt tcattatttc acggtttggt gaaccatttt
    18061 gtaaatcaac gatttgtcga gttattaagc acaaagctca agaagtagga gtaccagtga
    18121 taacgggaaa aggcttgcga catagtcatg cttcctatct tattaatgtt ttgaaaaaag
    18181 acattctgta cgttgcaaag tgtatgggac atgctgataa gtctacaact ttgaatacat
    18241 atagtcactg atttaacgca ttagataaaa cagtatctga agaaataacc caaaatgtaa
    18301 taagttcagg attagattcc attttatacc aaaattcctg ccaaacaact aattgatata
    18361 acgaagctta ttatatcgcc catataacag gatgtgttat tgttacaggg tacttgcttt
    18421 atgagcttgt ttaagctact aaaggtgtgt gccaccacgc caaacgcatg aagaaacttt
    18481 tgttttcaga aaactagatt cataatgaca aaatcaatca aagtagtaca ctatagatga
    18541 ggtgactacg atgattgatt ttattatttc tattgatgat tgc
//
