LOCUS       NZ_CAAHKK010000010     15417 bp    DNA     linear   CON 11-MAY-2024
DEFINITION  Streptococcus pyogenes strain A920, whole genome shotgun sequence.
ACCESSION   NZ_CAAHKK010000010
VERSION     NZ_CAAHKK010000010.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (03-APR-2019) WTSI, Pathogen Informatics, Wellcome Trust
            Sanger Institute, CB10 1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900983635.1-RS_2024_05_11
            Annotation Date                   :: 05/11/2024 02:49:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,709
            CDSs (total)                      :: 1,652
            Genes (coding)                    :: 1,595
            CDSs (with protein)               :: 1,595
            Genes (RNA)                       :: 57
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 48
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 36 of 57
            Pseudo Genes (incomplete)         :: 21 of 57
            Pseudo Genes (internal stop)      :: 23 of 57
            Pseudo Genes (multiple problems)  :: 19 of 57
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:58:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 67854
            Orig. end                         :: 83271
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CAAHKK010000010.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..15417
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="azole-containing-RiPP"
                     /region_number="1"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..15417
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..15417
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:13767](-)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13767)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     misc_feature    complement(133..144)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.03"
                     /tool="antismash"
     misc_feature    156..170
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.38"
                     /tool="antismash"
     gene            complement(1397..1897)
                     /locus_tag="E9649_RS06175"
     CDS             complement(1397..1897)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985256.1"
                     /locus_tag="E9649_RS06175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="QueT transporter family protein"
                     /protein_id="WP_002985256.1"
                     /transl_table=11
                     /translation="MTKLTVHDYVHIGLVAALYVVLTITPPLNAISYGMYQFRISEMMN
                     FLAFYHRKYIIAVTLGCMIANFYSFGLIDVFVGGGSTLIFVTLGVILFSKYQKDYLFNG
                     IFNKAFVYFSFFFATSMFTVAIELYFFGAPFLLTWFTTALGELVSLLIGSLIIDKLSQR
                     ISF"
     regulatory      complement(1895..2010)
                     /bound_moiety="preQ1"
                     /db_xref="RFAM:RF01054"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF01054"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="PreQ1 riboswitch class II; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            complement(2175..4907)
                     /locus_tag="E9649_RS06180"
                     /old_locus_tag="SAMEA3919117_01207"
     CDS             complement(2175..4907)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985259.1"
                     /locus_tag="E9649_RS06180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01207"
                     /product="SpnA family nuclease"
                     /protein_id="WP_136047859.1"
                     /transl_table=11
                     /translation="MINKKCIISVSLLTLAITLTSVEEVTSRQNLTYANEIVTQRPKRE
                     SVISDKSNFPVISPYLASVDFGERKTPLPTPDKGVKVTTEQSIAQVRKGPEERTYTVTG
                     KITSVINGWGGYGFYIQDSEGIGLYVYPQKDLGYSKGDIVQLTGTLTRFKGDLQLQQVT
                     AHKKLELSFPTSVKEAVISELETTTPSTLVKLSHVTVGELSTDQYNNTSFLVRDDSGKS
                     IVVHIDHRTGVKGADVVTKISQGDLINLTAILSIVDGQLQLRPFSLEQLEVVKKVTSSN
                     SDASSRNIVKIGEIQGASHTSPLLKKAVTVEQVVVTYLDDSTHFYVQDLNGDGDLATSD
                     GIRVFAKNAKVRVGDVLTISGEVEEFFGHGYEERKQTDLTITQIVAKAVTKTGTAQVPS
                     PLVLGKDRIAPANIIDNDGLRVFDPEEDAIDYWESMEGMLVAVDDAKILGPMKNKEIYV
                     LPGSSTRPLNNSGGVLLPANSYNTDVIPVLFKKGKQIIKAGDSYKGRLAGPVSYSYGNY
                     KVFVDDSKNMPSLMDGHLKPEKTNLQKDLSKLSIASYNIENFSANPSSTKDEKVKRIAE
                     SFIHDLNAPDIIGLIEVQDNNGPTDDGTTDATQSAQRLIDAIKKLGGPTYRYVDIAPEN
                     NVDGGQPGGNIRTGFLYQPERVSLSDKPKGGARDALTWVNGELNLSVGRIDPTNAAWKD
                     VRKSLAAEFIFQGRKVVVVANHLNSKRGDNALYGRVQPVTFKSEQRRHVLANMLAQFAK
                     EGAKHQANIVMLGDFNDFEFTKTIQLIEEGDMVNLVSRHDISDRYSYFHQGNNQTLDNI
                     LVSRHLLDHYEFDMVHVNSPFMEAHGRASDHDPLLLQLSFSKENDKAESSKQSVKAKKT
                     SKGKLLPKTGDSLVYVITLLGTASLLVPILLLTKGKKES"
     misc_feature    5109..5124
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.72"
                     /tool="antismash"
     misc_feature    5230..5241
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 18.98"
                     /tool="antismash"
     misc_feature    5458..5471
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 24.45"
                     /tool="antismash"
     gene            complement(5478..6596)
                     /locus_tag="E9649_RS06190"
                     /old_locus_tag="SAMEA3919117_01208"
     CDS             complement(5478..6596)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990425.1"
                     /locus_tag="E9649_RS06190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01208"
                     /product="ABC transporter permease"
                     /protein_id="WP_010922112.1"
                     /transl_table=11
                     /translation="MICFIKTLFVKIKRKKTSYVTFFLMPILTTLLALSLSFSNNNQAK
                     IGILDKDNSQISKQFIAQLKQNKKYDIFTKIKKEHIDHYLQDKSLEAVLTIDKGFSDKV
                     LQGKSQKLNIRSIANSEITEWVKAQTNYLLENYNIIGDVALGNEDTFNRILQKNQQLNY
                     DVKQVTLTDRSRSKAVSSTTTGFLLILMLGSTSVIYSGILADKSSQLYHRLMLSNLSRF
                     RYMLSYVCVGFVAFTIQIVIMLSLLKVFNISFFVPTSLLLIIFFLFSLLAIGFGLLIGA
                     ITQNSQQSSQLANLIVMPTSMLAGCLWPLSITPSYMQAIGKLLPQNWVLSAIAIFQSGG
                     TLSQAWPYLLALMGTALALISFSSLLLKPTKL"
     gene            complement(6593..7720)
                     /locus_tag="E9649_RS06195"
                     /old_locus_tag="SAMEA3919117_01209"
     CDS             complement(6593..7720)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985266.1"
                     /locus_tag="E9649_RS06195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01209"
                     /product="SagG family ABC transporter permease subunit"
                     /protein_id="WP_136047860.1"
                     /transl_table=11
                     /translation="MVLFHLIKKESLQIFRNRTALLMMVIFPILMIVILSFAFKSSFNT
                     ATTVPKLTIRYQLEGEKTDYQKNFLAFLKVLNQKLHLEAKPSNSLEKDRQRVSEGALTA
                     VLEVKKNQTIKVITNNINQQNADLINVLVKNYVDNAKTYDSIAALYPQQLNHIRKRSVD
                     YVKVSSIQTSKGMTSADYYAISMFTMITFYSMMSAMNLVLSDRQQRITNRIHLTGVSPS
                     LLVFGKLIGAMLATTVQLSLLYIFTRFVLRVNWGTNEWMLIGITASLVYLSVAIGIGLG
                     ISIKNEAFLTVASNTIIPIFAFLGGSYVPLTTLHSSIINQLSNISPIKWVNDSLFYLIF
                     GGQYNPIPVTLIVNISIGTIFIILALIGMRKQVTT"
     gene            complement(7729..8652)
                     /locus_tag="E9649_RS06200"
                     /old_locus_tag="SAMEA3919117_01210"
     CDS             complement(7729..8652)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017604.1"
                     /locus_tag="E9649_RS06200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01210"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_002990429.1"
                     /transl_table=11
                     /translation="MSFVQLTNVVKSYKNGKKAVNDVSLSIEAGNIYGLLGPNGAGKST
                     LINLILGLIPLSSGKITVLGQSQKTIRKISSQIGYVPQDIAVYPDLTAYENVELFGSLY
                     GLKGAQLKKQVLKSLEFVGLHSQAKQFPSQFSGGMKRRLNIACALVHSPKLIIFDEPTV
                     GIDPQSRNHILESIRLLNKEGATVIYTTHYMEEVEALCDYIFIMDHGQVIEEGPKFELE
                     KRYVANLANQIIVTLTDSRHLELADKPDWSLIEDGEKLMLKIDNSDMTSVVHQLTQANI
                     TFSEIRHNHLNLEEIFLHLTGKKLRD"
     gene            complement(8675..9358)
                     /locus_tag="E9649_RS06205"
                     /old_locus_tag="SAMEA3919117_01211"
     CDS             complement(8675..9358)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985270.1"
                     /locus_tag="E9649_RS06205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01211"
                     /product="SagF family protein"
                     /protein_id="WP_002990431.1"
                     /transl_table=11
                     /translation="MMLLVLLSFLGLTTLWLTSYRRRCLARWHLQWLVALSYQDFLDVL
                     LSLFQFVIIILVLFFYSATINLGEVLTFLTQTSWHWQILCYLVLYLMAIIEMTLLVLIL
                     IFDVLLQKDSRLLFKKITWLPFRQDKPVLSILLLGIVILVDSLFYLGLLILLGEQSLTS
                     LATLILGYGIVKACRYSGWLNVLLAFCLFTIVGLWAVTATLLYGWLVGAMILTVTYLMI
                     SCKEY"
     gene            complement(9355..10026)
                     /locus_tag="E9649_RS06210"
                     /old_locus_tag="SAMEA3919117_01212"
     CDS             complement(9355..10026)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017602.1"
                     /locus_tag="E9649_RS06210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01212"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_002990433.1"
                     /sec_met_domain="Abi (E-value: 9.2e-12, bitscore: 37.6,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLSIQCLNLCFLLVTFCPSIPMQAIFGKEDSGYAFNLIGFLRAT
                     LIYDILALVSIYVLSPQITLSLESIDSKTFFMGLVFCVLIVLIELVFLHGLRCWQKKQW
                     LPATFSFVGTTNDWSKIGYPLLLALFEETIYRFLWFNILAFQWYLPTIIVLIVTSFCYA
                     LNHLLMGKSIFYAKLVTGIIYGSIYMLTSQLWLVVIMHVGGNLLVECLSHLQTKKKKEV
                     T"
     gene            complement(10001..11359)
                     /locus_tag="E9649_RS06215"
                     /old_locus_tag="SAMEA3919117_01213"
     CDS             complement(10001..11359)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407460.1"
                     /locus_tag="E9649_RS06215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01213"
                     /product="YcaO-like family protein"
                     /protein_id="WP_002990434.1"
                     /sec_met_domain="YcaO (E-value: 3e-64, bitscore: 210.1,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 1.8e-112, bitscore:
                     368.2, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLYYYPSFNHIFDELKSLSGNRTGILNQSQVPVCNHPHDVYLKSI
                     TGQMPDYHKQFIGELSQVSYHIIGYGSYYEEALIKYLGESIERYATVIAGDLLSDRIVY
                     ASYNELKLLHKVMPLEYLQVFTQEQIALSCDLQMMMCDKMVTENDVLGWVKCPMFFEDA
                     EMYVPAQMLCVGYKTNETVGERRIIPGFSTGTASHKTLEAAMCNSLIEYIQIDSMMLSW
                     YTKKPCPKIIVDDPDIEVILEEARLGKDSLYDIIPIDMTVGEDNPLYTFGIILKNKYDE
                     GPYLLFGVQAGLDPKHALLRGIMEASAISYSYYYNLLYQKASLANIECEEPLFLDLDSN
                     VFYYAHPKDQDHKWKAFEPLISGEVLLSDLEDHSGKDKKEDLKTLLAYAKKVSPNAVFL
                     DITPPEALEKGWYVTRVLMPELLEMCIPAFPFANHPRMRQFGGVTNAFVHPMP"
     gene            complement(11379..12437)
                     /locus_tag="E9649_RS06220"
                     /old_locus_tag="SAMEA3919117_01214"
     CDS             complement(11379..12437)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03603"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cytolysin_C_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985275.1"
                     /locus_tag="E9649_RS06220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01214"
                     /product="bacteriocin biosynthesis cyclodehydratase SagC"
                     /protein_id="WP_023613068.1"
                     /sec_met_domain="Cytolysin_C_RRE (E-value: 1.3e-41,
                     bitscore: 133.3, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03603 (E-value: 4.1e-141, bitscore:
                     462.5, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYQLNSNVRVVTFQDTFCFRKGIWDFNEAILDLTQEPQNLKIVY
                     QEIVSQLVKGVAIDTETYENALEPETFANLMEVISGLYYNDMLMLEDDYNLEENVMKIL
                     MGNFRFMAQAGHMVSNDPVLFISDSTYVNESAELLAEQLHLQLQVASDDLKMLIQQTDV
                     SSRLDALEHRRNMNCLSEALCDYQSIIICQERLNIMMLRHLNEVSVAMKKQLVIGFVDG
                     PFLHTCTLNPPHSADFDSLERRVLARLQDSTLYQHFANQILPATQDVSQAYLPLLNVLM
                     NLVVSEAFIIAQTGSSKFEGRLLSIYLPTLEIQVQDILKMSNSQTQGALAKLKYEDQQI
                     STREIVKKLLDE"
     aSDomain        complement(12168..12437)
                     /aSDomain="Cytolysin_C_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing discrete C protein in a
                     SLS/cytolysin LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_E9649_RS06220_Cytolysin_C_RRE.1"
                     /evalue="4.50E-42"
                     /identifier="RREFam014.1"
                     /label="E9649_RS06220"
                     /locus_tag="E9649_RS06220"
                     /protein_end="90"
                     /protein_start="0"
                     /score="133.3"
                     /tool="antismash"
                     /translation="MKYQLNSNVRVVTFQDTFCFRKGIWDFNEAILDLTQEPQNLKIVY
                     QEIVSQLVKGVAIDTETYENALEPETFANLMEVISGLYYNDMLML"
     gene            complement(12434..13384)
                     /gene="sagB"
                     /locus_tag="E9649_RS06225"
                     /old_locus_tag="SAMEA3919117_01215"
     CDS             complement(12434..13384)
                     /codon_start=1
                     /gene="sagB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922108.1"
                     /locus_tag="E9649_RS06225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01215"
                     /product="streptolysin S biosynthesis dehydrogenase SagB"
                     /protein_id="WP_010922108.1"
                     /sec_met_domain="PF00881 (E-value: 4.8e-34, bitscore:
                     110.2, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFFTKEQQPKENCPPITVEKARQLFEFNTNHLSLSDYHHQTVLK
                     TSKQLVAQHLMPNATDNLSQHFLMNYKANNNYLGFQASIVDFFTDSAVANFSSSYVYES
                     QEKIIRLPKPTKISTALSTCIIKRRSHRQFSDRQMPLQDLSNILYYACGVSSQASIRDG
                     ASDKITLRNCASGGGLYPIHLVFYARNISKLIDGFYEYLPYQHALRCYRHSSEENVRDF
                     AEYGAINAENCNIIIIYVYHYMKNTRKYGNQATAYAFIESGEIAQNIQLTATALTYGSI
                     DIGGYNKEYLQELLDLDGLGEHVIHMTLVGTKESQ"
     misc_feature    13582..13599
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 22.53"
                     /tool="antismash"
     gene            complement(13606..13767)
                     /gene="sagA"
                     /locus_tag="E9649_RS06230"
                     /old_locus_tag="SAMEA3919117_01216"
     CDS             complement(13606..13767)
                     /codon_start=1
                     /gene="sagA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03602"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985285.1"
                     /locus_tag="E9649_RS06230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01216"
                     /product="TOMM family cytolysin streptolysin S"
                     /protein_id="WP_002985285.1"
                     /sec_met_domain="TIGR03602 (E-value: 7.9e-31, bitscore:
                     98.4, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKFTSNILATSVAETTQVAPGGCCCCCTTCCFSIATGSGNSQGG
                     SGSYTPGK"
     misc_feature    14293..14306
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.06"
                     /tool="antismash"
     gene            <14330..14446
                     /locus_tag="E9649_RS06235"
                     /pseudo=""
     CDS             <14330..14446
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611996.1"
                     /locus_tag="E9649_RS06235"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="IS3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="QETFYSLEQLTLKTKEEVHWWNYHHLHSNLNYQTPITK"
     gene            complement(14632..>15417)
                     /locus_tag="E9649_RS06240"
                     /old_locus_tag="SAMEA3919117_01217"
     CDS             complement(14632..>15417)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990440.1"
                     /locus_tag="E9649_RS06240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01217"
                     /product="LPXTG cell wall anchor domain-containing protein"
                     /protein_id="WP_136047861.1"
                     /transl_table=11
                     /translation="KQTEAVAKALKAAIAAVDKATTAEGINQELGKGITAINKAYRPGE
                     GVKARKEAAKANLEKVAKETKALISGDRYLSETEKAAQKQAVEQALAKALGQVEAAKTV
                     EAVKLAENLGTVAIRSAYVAGLAKDTDQATAALNEAKQAAIEALKQAAAETLAKITTDA
                     KLTEAQKAEQSENVSLALKTAIATVRSAQSIASVKEAKDKGITAIRAAYVPNKAVAKSS
                     SANHLPKSGDANSIVLVGLGVMSLLLGMVLYSKKKESKD"
ORIGIN
        1 ttcactacca caagatgggc atagtttagg aataagcatg acttcttgct ggttccgctt
       61 actcataacg acatttaaga cagcaggaat aatgtcccct gccttatata caatcactgt
      121 atcgccaata cggatatctt tttcggcaat ataatccaca ttatgtaggg ttgcacgact
      181 cacggttgtc cccgctagtt gcacaggagt tagattcgct gtaggtgtga ccacgcctgt
      241 tcgtcccact gtccagtcaa ccgaaaggat ttctgcctct ttttcttctg ctggaaattt
      301 gtaagcaatg gcccagcgtg gagctttaac cgtaaaccct agctcttctt gcatggctag
      361 gctattaact ttaataacaa cgccatctat gtcataagct aattgatctc tttttgcctc
      421 aatagttttg ataaaatccc aaatctcatc catagacgat gtgagttgat aatacggatt
      481 tactgaaaaa cctagatctg ctaattctgc taagacctca ttttgttgat ttctagctgt
      541 cggactagct tcttgataca aaaaagtggc tagttcacgc ttagcaacca ctgccgtatc
      601 tagctgcctt agtgtcccag cggcagcatt tctaggatta gcaaattcag tctccccatt
      661 ttcttggcgt gcttcattga tcgctttaaa ggactgacga gacatgtaag cctctcctcg
      721 aacggtgatg gttaaaggct cactcaattg gtgaggaata tcctttattt ttttgatatt
      781 ttctgtgata ttttcaccga tattgccatc accccgtgtt gctccaacct gtaagaagcc
      841 attctcataa ctcaaggaaa tagataaacc atcaattttt aactctgcta gataggtggc
      901 attcggaaat tcggccttga cgcgcttatc aaaagcatcc agctcctcac gtgaaaaagc
      961 atcctgcaaa ctaaaaagcg gatactgatg tcgatatttt tcaaacccct ttaaaatagt
     1021 ccctccaacc tgctgcgttg ggctatcttg caagacatac tcgggatatg actgctctaa
     1081 agtcaccagt tcacgataaa gcttatcata gtcactgtca gaaactgatg gggcatcttt
     1141 agtataatag tcataacggt aacggttaag aagatctgtt aattctttta tgcgtttttt
     1201 catactttta ttttatcata aaagataaca aatgagctat ttctatatca taacaacatc
     1261 aaaagtaatc gttggccact ccatatggta ctattagcta aagtgttaaa tatttctatc
     1321 tagaacgatt ttaacattac aaacaacata aaaaagagaa gggtattgac ccaactcttt
     1381 tgagtatgat gcattactaa aaggaaattc tttgagacaa cttatcaata ataagtgatc
     1441 ctatgagcag agatactaat tctcccaacg cagttgtaaa ccatgttaat aaaaatggag
     1501 ctccaaagaa gtaaagttcg attgctacag taaacatgga agttgcaaaa aagaaagaaa
     1561 agtaaacaaa agctttatta aaaatgccat taaaaagata atctttttga tacttactaa
     1621 acaaaataac acctaaggtc acaaaaataa gagttgaacc gccgcctaca aagacatcaa
     1681 tcagtccgaa actataaaag ttagcaatca tacatccaag agtcaccgca ataatatact
     1741 tgcgatgata aaaagctaag aaattcatca tttcagatat tctaaattga tacatcccat
     1801 aagaaatcgc atttaaaggc ggggtaatag ttaagacaac atacaaggca gctactagcc
     1861 caatgtgaac atagtcgtgt acagtcaatt ttgtcatttt ttctccttta acgtctggat
     1921 aactctcaaa agctatctac gtttctaata tgcttggtga aagggaacta agcaccaagg
     1981 gttgcaaagc aacggttaca ttgtaccata aaacaattag cttgacaaaa gtctttagca
     2041 agtaaagctg tcttattgtt atcttctttt gttatcaata ttagttttta tatagtcatc
     2101 cattttagct taaggtctaa cgtaagtata tcaagccttt aacgactctt tatgaactcc
     2161 aattcttcaa atcgctatga ttcctttttg cctttagtca ataataaaat aggcactaat
     2221 aaactagccg ttcctagtag cgttatcaca taaacaagac tatctcctgt ttttggcaac
     2281 agttttcctt ttgaagtttt tttagctttt acactttgtt tagaagactc tgccttatca
     2341 ttttctttgg aaaatgataa ttgaagtaac aatggatcat gatctgatgc gcgtccgtga
     2401 gcttccataa atggggaatt cacatgaacc atgtcaaatt cgtagtgatc aagtaaatgg
     2461 cgtgaaacta atatattatc aagggtctga ttattgcctt ggtgaaaata agaataccga
     2521 tctgaaatat catgtcggct caccaagtta accatatcac cttcttcgat taattgaatc
     2581 gtctttgtga attcaaaatc attaaagtca cctagcatca caatattagc ttggtgtttt
     2641 gccccttctt tcgcaaattg tgctagcata ttagccaaga cgtgacgtct ttgctcagat
     2701 ttaaaagtga ctggttgcac acgaccataa agagcattat ccccacgctt agagttcaaa
     2761 tgatttgcaa caacaacgac tttacgacct tggaagataa attctgctgc tagtgattta
     2821 cgaacatctt tccaagcggc gttagttgga tcaattcgac caacactaag gtttaattct
     2881 ccattaaccc aagttagagc atcacgagca ccgccttttg gcttatcaga aaggctgacg
     2941 cgctctggtt gataaaggaa tcctgttcga atattaccac ctggttgacc tccgtcaaca
     3001 ttattttctg gagcaatatc aacataacga taagttgggc cacctagttt tttaatagca
     3061 tcaatgaggc gttgtgcgct ttgtgtcgca tccgttgtcc catcatcagt cggcccatta
     3121 ttatcttgga cttcaattaa tccaataatg tctggagcat tcagatcatg aataaaggat
     3181 tcggcaatcc gtttgacctt ctcatcttta gttgaagaag gattggctga gaagttttca
     3241 atattgtaag aagcaatgct taacttgcta aggtcttttt gcaagtttgt tttttcaggt
     3301 tttagatgac catccattaa acttggcatg tttttgctgt catcaacaaa gaccttgtaa
     3361 ttaccatagc tataagatac tggcccagct aatcttcctt tgtaagagtc tcctgcttta
     3421 ataatttgtt tgcctttttt gaaaagaaca ggaatcacat ctgtgttata agaattagct
     3481 ggaagtaata ctccacctga attatttaac ggtcttgtac tagagccagg taagacataa
     3541 atttctttat ttttcattgg accaaggatt ttagcatcat caaccgccac taacatgcct
     3601 tccattgatt cccaataatc aatagcgtct tcttctggat caaacacacg caagccatca
     3661 ttatcaataa tattggctgg cgcgatacga tctttcccta aaacaagcgg tgatggaact
     3721 tgagctgtcc ctgttttggt cactgcttta gccacaattt gggtgatggt aaggtcagtc
     3781 tgcttacgtt cctcataacc atgaccaaag aattcttcca cttcacctga aatggtcaaa
     3841 acatcgccga ctcgaacctt agcgttttta gcaaaaacac gaataccatc tgaagtcgct
     3901 aaatcaccat caccattaag atcttgaaca taaaaatgag tggaatcgtc taaataagtg
     3961 acaacaacct gttctacggt gaccgctttt ttgagaagtg gcgacgtatg actagctcct
     4021 tgaatctcgc ctattttcac aatattacga gatgaagcat cactatttga gcttgtgacc
     4081 tttttaacca cttccaattg ttcaagagaa aacggtctta attgtaactg accatcaaca
     4141 atagacaata tggctgtgag gttaatcaaa tcaccctgac ttattttagt aacaacatca
     4201 gcccctttaa cccctgtacg atgatctata tgaacaacta tacttttacc actatcatcc
     4261 cttacaagga aagatgtgtt gttatattga tcagttgata attctccaac tgtcacgtga
     4321 gataacttaa ctaatgttga gggtgttgtt gtttctaatt ctgatattac tgcttcttta
     4381 acagaagtcg gaaaagataa ctctaacttt ttgtgtgcag tcacctgttg gagttgtaaa
     4441 tcacctttaa agcgagtaag tgtgcctgtt aattgaacaa tatctccctt actgtatcct
     4501 aaatcttttt gaggataaac ataaagtcca ataccttcac tatcttgaat ataaaagcca
     4561 tagcctcccc agccattgat cacactcgta atcttgccag taacagtata ggttctttct
     4621 tcaggcccct ttcttacttg agcaatagac tgttcagtag ttacttttac tcctttatca
     4681 ggtgttggca aaggtgtttt tctctcacca aaatccacac ttgctaggta aggtgatatg
     4741 acgggaaaat tcgatttatc actaataaca gattctctct ttggcctttg tgttacgatt
     4801 tcattggcat aagtcaaatt ttggcgtgaa gtaacttctt caacactagt aagcgtaata
     4861 gctaatgtca acaatgaaac agatattata catttcttgt taatcatgat atctcctttt
     4921 aatgtgatta gtttaagaca acaacaagat tttatttttg aatattaacc tccacctgag
     4981 actatgaatt gggatacact ttctgtttgc attaattata ctatcaagta acacgattag
     5041 atcttttctt ttaatctgtt aagtcgccca attaaagact tgtttgatct gacatagcat
     5101 cacaagcacc cctgatagcg aacaagacag ctttatagca ttcgatacat gcttattgta
     5161 acaaaaacat cctataaaat aaatacgttt tcacaacttt ttttaacaac attagttttt
     5221 atgtttattg aaaacgtttt ttaaaatact ttgacaactc atttatcaac aaaaacgaac
     5281 tttctagaga ggtcgctttt gataatatgc tctctaaaaa acacaataac aacagtaaca
     5341 tcgcaatcgc ttttaacaaa agataagtgc actagagaaa atataagcaa aaagcaaccc
     5401 ttttattgca tataagccaa taaaagggct acctggtagt tagctaatta ggaaagtatt
     5461 ttttaacaaa agactaatta tagtttggta ggttttaata ataaacttga aaaactaatc
     5521 aaagctagtg ctgttcccat tagagctaac aagtatggcc aagcctgaga taaggtccct
     5581 ccactttgaa aaatagctat ggctgataaa acccaatttt gtggtaataa cttaccaatt
     5641 gcttgcatat aagaaggcgt aatagacaat ggccataaac agccagccaa cattgaagtc
     5701 ggcattacaa taagattagc taactggcta ctttgttggg aattttgtgt gatagctcca
     5761 atcagcaggc caaagcctat cgctaataaa ctaaaaagga aaaaaataat caaaagaagt
     5821 gatgtcggaa caaaaaaact aatattaaat acttttaaca aactcagcat aatgacaatt
     5881 tgaatcgtaa aagcaacaaa tcctacacag acgtaactca acatatagcg aaaacgagat
     5941 aagttcgata acattaatcg atggtataac tgactagatt tatctgccaa aataccactg
     6001 taaatcacgc tcgtactacc taacattaga ataagcaaaa atcctgtcgt tgtagaagat
     6061 actgctttgc tacgtgatcg gtctgtcaaa gttacttgct taacatcata atttaactgt
     6121 tggttttttt ggagaattct attaaaagta tcttcgttac ctagagccac atcccctata
     6181 atattatagt tttccaatag ataattggtc tgtgccttta cccactctgt aatttcgcta
     6241 ttagcaatcg aacgtatatt gagtttttga gattttcctt gcaacacttt atctgagaat
     6301 cctttgtcaa tagtcaatac cgcttctaga gatttatctt gaaggtagtg atcaatatgc
     6361 tcttttttga ttttggtaaa aatgtcgtac tttttgtttt gctttagttg agcaataaat
     6421 tgtttagata tctgactatt atctttatct aatatcccaa ttttagcttg attattattt
     6481 gaaaaactca aagataaagc caaaagtgtc gttaaaatag gcattaaaaa gaatgtcaca
     6541 taacttgttt ttttgcgctt tatcttaaca aatagagttt ttataaaaca aatcatgtcg
     6601 tcacctgctt tctcatacct atcaatgcca atattataaa aattgttccg atactaatat
     6661 taacgatcaa agttacagga atcggattat attgaccacc aaaaataaga tagaacaaac
     6721 tatcattaac ccatttaata ggagatatat tcgacaattg attaataata gagctgtgta
     6781 atgttgtcaa tggaacgtaa ctgcctccta aaaaggcgaa tataggaata atagtattgg
     6841 atgcaaccgt taaaaaagcc tcatttttaa tgcttatgcc tagcccgata cctatagcta
     6901 cagagagata gactaaggag gctgttatac caataagcat ccactcatta gtgccccaat
     6961 taactcgtaa aacaaacctt gtaaaaatgt ataaaagact caattgaaca gttgttgcta
     7021 acatagcacc tattaatttt ccaaagacca aaagacttgg ggaaactcct gttaagtgaa
     7081 tacgatttgt aatccgttgt tgacgatctg acaaaacaag gttcatcgca gacatcatac
     7141 tataaaaagt aatcatggta aacatggaaa tagcataata atcagctgat gtcattcctt
     7201 tacttgtctg tattgaactg accttaacat agtccacact tcgctttctg atatgattta
     7261 attgttgagg ataaagagct gctatcgagt cataagtttt agcattatct acataatttt
     7321 ttactagcac attgatcaaa tctgcatttt gctgattaat attattagta ataaccttaa
     7381 tggtctgatt cttcttcact tctaaaacag ccgttaaggc tccttcactg accctttgtc
     7441 gatctttttc aagagaatta ctaggtttag cctctaaatg aagtttttgg tttaaaactt
     7501 ttaaaaaagc aagaaaattt ttctggtaat ccgttttttc accctctaat tggtaacgaa
     7561 tggtcaattt agggactgtt gtcgcagtat taaaacttga tttaaaggca aaacttaaaa
     7621 taacgatcat caaaattgga aaaatcacca tcatcaataa ggctgttcgg tttctaaaaa
     7681 tctgtaaact ttcttttttg attaaatgaa ataaaaccat agtaacctct aatctcgtaa
     7741 cttcttacct gttaagtgta agaaaatttc ttctaaattc aaatggttat gtctaatctc
     7801 gctaaaagta atattggcct gtgtgagctg atgaacaact gatgtcatat cactattatc
     7861 aatcttcaac atgagttttt ctccatcttc tatcaaagac caatcaggct tatctgccag
     7921 ttccaaatga cgtgaatctg ttagagttac aataatctga tttgctagat ttgcaacgta
     7981 acgtttttcc agttcaaatt taggtccttc ttcaataact tgaccatgat ccataataaa
     8041 aatataatca caaagagcct ctacttcttc catataatgg gtcgtataaa taactgtggc
     8101 accttctttg tttagcaaac gaatcgactc taaaatatga ttacgtgatt gaggatcaat
     8161 ccctacagtc ggttcgtcaa aaatgattaa tttaggtgaa tgaactagcg cacaagcgat
     8221 atttaaccgt ctcttcattc ctcctgagaa ttgacttgga aactgcttag cttgggagtg
     8281 tagccccaca aattctaaac tttttagaac ttgtttttta agctgagctc cctttaagcc
     8341 ataaagtgac ccaaatagtt ctacattttc ataagcagtt aggtctggat aaacagcaat
     8401 gtcttgagga acataaccta tctgcgaact tatttttcga atagtctttt gggattgccc
     8461 taaaacagta attttaccag aactcaaagg gatcaagcct aagataagat taatcaaggt
     8521 agacttacca gcaccatttg gtcctaacaa accataaata ttacctgctt caatagacaa
     8581 ggaaacatca ttgacagctt tcttgccgtt tttgtaggac ttgacaacat ttgttaattg
     8641 tacaaaactc atatatcact cctttttaat attgctaata ctctttgcaa ctaatcatca
     8701 aataagtcac cgttaatatc atcgcaccta ctagccaacc atataataaa gttgccgtaa
     8761 ctgcccatag tccaactata gtgaaaagac aaaaagctaa tagtacattt aaccaacctg
     8821 aatagcgaca agccttgact atcccatagc ctaaaataag cgttgctaaa cttgttagcg
     8881 actgttctcc taataatata agcaagccca aataaaagag actgtctact agaataacta
     8941 tgcctagcaa aagtatactt aagactggtt tatcttgtct aaaaggcagc caagttattt
     9001 ttttaaagag caatcgacta tctttctgga gcaaaacatc aaagataaga attaaaacta
     9061 aaagcgtcat ctctatgatg gccataagat acaacactaa ataacaaaga atctgccaat
     9121 gccagctagt ttgtgtcaaa aaggtcagaa cctctcctag attaatagta gctgagtaaa
     9181 agaataaaac aagtataata atgacaaatt gaaacagact cagtaagaca tctaaaaaat
     9241 cttgatagga taaggccact aaccattgaa gatgccatct agccaaacaa cgtcttcgat
     9301 aactggtcaa ccaaagagta gttagaccta aaaacgacag caaaaccaat agcatcatgt
     9361 cacctccttc ttcttttttg tttgaagatg gctaagacac tcaactagca agttccctcc
     9421 tacatgcatt atcacaacca accacaattg actagtcagc atgtaaatac taccataaat
     9481 gatgcctgtt accaacttag cataaaaaat ggatttcccc atcaataagt gatttaaagc
     9541 atagcaaaaa ctagttacaa ttaaaacaat aattgttggt aaataccatt gaaaagctaa
     9601 tatattaaac cacaaaaaac gataaatcgt ctcttcaaat aaagctagta ataaaggata
     9661 gccaatctta gaccaatcat ttgtcgttcc tacaaacgag aaagttgcag gaagccattg
     9721 ctttttttgc caacaacgta aaccatgtaa gaaaacgagt tcaatcagta ctatcaagac
     9781 gcaaaataca agtcccataa agaacgtctt actatcaata ctttcaagag acaaggttat
     9841 ttgaggtgac aaaacataaa tacttactaa agccaaaatg tcataaatca gagttgctct
     9901 tagaaaacca attaaattaa atgcataacc actatcttct tttccaaaaa tagcttgcat
     9961 aggaattgaa ggacaaaaag ttaccaacaa aaaacaaaga ttaaggcatt ggatggacaa
    10021 aggcatttgt tacacctcca aactgtctca ttcgtgggtg attagcaaaa ggaaatgctg
    10081 gtatacacat ttcaagaagt tctggcatca gaactcgcgt gacgtaccag cctttttcta
    10141 gagcttcagg aggtgtaata tctaaaaaga cagcattagg actgactttc ttagcataag
    10201 ctaataaagt cttcaaatct tcttttttat ctttaccaga atgatcttcc aaatcactta
    10261 acagaacttc tcctgaaatc aaaggttcaa aggccttcca tttatggtct tggtccttgg
    10321 gatgtgcata atagaaaaca ttactatcta aatctaaaaa caaaggttct tcgcattcaa
    10381 tatttgcaag ggaagctttt tgatataaaa gattatagta gtaactatag ctgatagctg
    10441 aagcttccat gatccctctt agcaaagcat gtttaggatc taacccagcc tgcactccaa
    10501 acaagaggta aggcccttca tcatatttat ttttgagaat gattccaaac gtataaagag
    10561 gattatcttc tcctacagtc atatcgatag gaataatgtc gtatagactg tcttttccca
    10621 gtctagcttc ttctaaaatc acttcaatat caggatcatc aacaataatc ttggggcaag
    10681 gcttcttagt ataccagcta agcatcattg aatcgatctg gatgtattca atcaaactgt
    10741 tgcacatagc cgcttctaac gttttgtgag aagctgttcc cgtagaaaat cctggtatta
    10801 tccgtctttc tcctacagtc tcatttgttt tatacccaac acaaagcatt tgagctggaa
    10861 catacatctc tgcgtcctca aagaacatgg gacatttaac ccagcccaat acatcgttct
    10921 cagttaccat tttatcgcac atcatcattt gcaagtcaca agataatgcg atctgttctt
    10981 gagtaaacac ttgcaagtat tctaaaggca tcactttatg taacagtttt aactcattat
    11041 aagaagcata gacaatccga tctgatagta agtctccggc aattacagta gcatagcgtt
    11101 caatactttc tcctaaatac ttgataagtg cttcttcata gtaactgccg taaccaataa
    11161 tgtgataact aacttgactc aactcaccta taaattgttt atgataatct ggcatttggc
    11221 cagtaatact ttttaagtaa acatcgtgag gatggttgca aactggaact tgagattgat
    11281 ttaagatacc tgttcgattg ccacttaaac tttttaattc atcaaaaata tgattaaaag
    11341 aaggataata gtataacata atagattctc cttataggtt actcgtcaag gagtttttta
    11401 acaatctcac gtgttgatat ctgctgatcc tcatatttta attttgccaa agctccttgt
    11461 gtctgtgaat tagacatttt caaaatatct tggacctgaa tctcaagcgt cggtaagtaa
    11521 atgcttaata aacgtccctc aaatttagaa ctacctgttt gagcaataat gaaagcttcg
    11581 ctaacgacta aattcattaa aacatttaac aatggtaaat aggcctggct cacatcttgt
    11641 gttgctggta aaatctgatt agcaaaatgt tgatagagag ttgagtcttg taaacgtgcc
    11701 aaaactcttc tttctaagct atcaaagtca gcactatgag gaggattcaa agtacaagtg
    11761 tgcaagaatg gtccatctac aaaaccaatc actaattgtt ttttcatagc tacgctaact
    11821 tcattcaagt gtcgcaacat cataatattc aagcgttctt gacaaataat aatactttgg
    11881 taatcgcaca aggcttctga taaacaattc atgttacggc gatgctccaa agcatctaaa
    11941 cgcgaactaa catctgtctg ctgaattaac atttttaagt catcgctagc cacttgcaat
    12001 tgtaaatgca gttgttcagc tagcaactca gcagattcat taacataagt cgaatcactg
    12061 ataaacaaaa caggatcatt gcttaccata tgacctgctt gcgccataaa acggaaatta
    12121 cccattaaaa ttttcatgac attttcttca agattgtagt catcctcaag catcagcata
    12181 tcattgtaat acaagcctga aatgacttcc attaaattag cgaacgtctc aggttctaaa
    12241 gcattttcat aagtttcagt atcaatggct actcccttaa ccaactgtga aactatttct
    12301 tgataaacta tctttaaatt ttgaggttct tgtgtcaaat ctagaatggc ttcattaaag
    12361 tcccagattc cttttctaaa acaaaatgta tcttgaaatg tcacgacacg aacattacta
    12421 ttaagttgat atttcattga gactccttag ttcctacgag tgtcatgtga atcacatgct
    12481 ctcctagccc atctaaatct aataattctt ggagatattc cttattataa ccaccaatat
    12541 caatacttcc ataagttaag gcagttgcag tcaattgaat attctgggct atttctcctg
    12601 attcaataaa agcataggca gtcgcctgat tcccatattt acgtgtattt ttcatgtaat
    12661 ggtagacata aataataata atattacaat tttcagcatt aatagcaccg tattccgcaa
    12721 aatctctaac gttttcctca gagctatgcc gataacacct tagtgcatgc tgatagggta
    12781 gatattcata gaaaccatct attaatttac tgatgtttct agcataaaaa actaaatgaa
    12841 tagggtataa acctccacct gaagcacagt ttctgagtgt aatcttatct gatgctccat
    12901 ctctaattga tgcttgtgaa ctaacaccac atgcataata aagaatgttt gataaatctt
    12961 gaagaggcat ttgtctatct gaaaattgac gatgacttct tcgttttata atacatgtcg
    13021 acagagcagt tgatatcttg gtaggttttg gtaaacgaat tatcttttcc tgactttcat
    13081 aaacgtaact acttgaaaaa ttagcaacgg cagaatctgt aaaaaagtcg acaatactag
    13141 cttggaagcc taaataatta ttattagctt tatagttcat caaaaaatgt tgactaagat
    13201 tatcggttgc attaggcatt aaatgttgag caactagctg ctttgacgtt tttagcaccg
    13261 tttgatgatg gtaatccgat aaggacaagt ggtttgtatt aaattcaaac aattgccttg
    13321 ctttttcaac agttattggc ggacaattct ctttaggttg ttgttccttt gtaaaaaatg
    13381 acataactat ctttcctatc tcattttact aaacatatag taattagcag gtactgtcta
    13441 gtacctgcta attacctgag acgttagcat caagaagatt acttttgtct catgttttct
    13501 aacacctcta tgccattcat ctataatcag aagttaccaa agataactta gttgctagca
    13561 aactcattac cttaatatca ctatcacata gagatgctaa atagattatt tacctggcgt
    13621 ataacttccg ctaccacctt gagaattacc acttccagta gcaattgaga agcaacaagt
    13681 agtacagcag caacagcagc ctccaggagc aacttgagtt gtttcagcta cactagtagc
    13741 taaaatattt gaagtaaatt ttaacataag gtttacctcc ttatctaata agtaactgat
    13801 aagaacacga gtcgtttatt tttaacctta ttttaaaaat aaagttaaca caacaaggac
    13861 aaggctagct caattgtact gttgtaacac aacaactatc tagttcttat cacttttatt
    13921 atagtaaaaa atgattaata tgtaaaccct ttctttttaa tattatcaaa aatgacaaaa
    13981 aaaataataa ttgattaata tagaaacaat tatgatctaa tatactgaat tttataatat
    14041 attctatcaa taactatgtg taaacaatca agtagaaatg tctttattaa gcgaatcaat
    14101 caaggttgta gagtaaatgc tggactagat ttcatgtaga aattagtaaa agttaggaga
    14161 ttttttggtc gtttcaaacg ataacatcat cttcttataa caagaacttc actcagagat
    14221 aaactattct catactttag tagcctcttt tgagcttgta gcacgaaaat tcgctcgaac
    14281 tgatttaaaa taggcatttt atctgctcgc ttgatcccta ctgcgcaacc aagaaacctt
    14341 ttattcacta gaacaattaa cccttaaaac caaggaggaa gtccactggt ggaactacca
    14401 tcaccttcac agtaatctta attatcaaac acctataact aaatgagtca tcgtttgaac
    14461 aaaaaacgcc ttataaattc tgtacagaaa actgttgcct tttcaattga actttgaaat
    14521 gttttcaata cactccgttc ttgagccctt acgatccaaa aaaccaaggt gatttcaaaa
    14581 tcaccttggt ttgaaaatat agtagaaagc aatttggata aagccaggtt cttagtcttt
    14641 actttctttt ttcttgctat aaagcaccat acctaaaaga agagacataa ctcctaagcc
    14701 aacaagaaca attgagtttg catcacctga ttttggaaga tggttcgctg acgatgattt
    14761 tgcgactgcc ttattaggca cataggctgc acggatagca gtaatacctt tatcttttgc
    14821 ttctttcaca gacgcaatag attgtgctga acgaacagtc gcaatagccg tcttaagcgc
    14881 taatgataca ttttctgatt gttcagcttt ttgagcttca gtcaatttag catcagttgt
    14941 aatcttagca agtgtttctg ccgcagcttg tttaagagct tcaatagcag cttgtttcgc
    15001 ttcgttaaga gcagctgttg cttgatcagt atctttagct aaaccagcaa catatgctga
    15061 acggatagct acagtaccaa ggttttctgc caacttaaca gcttcaactg tcttagcagc
    15121 ctcaacttga ccaagtgctt tcgcaagagc ttgctcaaca gcttgttttt gggctgcttt
    15181 ttcagtttcg ctcaagtaac ggtctcctga aataagagct ttagtttctt tagctacttt
    15241 ttcaagatta gctttagcag cttctttacg tgctttaaca ccttcacctg gacggtaagc
    15301 tttgttaata gctgtgatgc ctttaccaag ttcttggtta atgccttcag ctgttgtcgc
    15361 tttatcaacc gctgcgatag cagctttaag ggctttagca acagcttctg tttgttt
//
