LOCUS       NZ_CAAHKK010000009     41176 bp    DNA     linear   CON 11-MAY-2024
DEFINITION  Streptococcus pyogenes strain A920, whole genome shotgun sequence.
ACCESSION   NZ_CAAHKK010000009
VERSION     NZ_CAAHKK010000009.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (03-APR-2019) WTSI, Pathogen Informatics, Wellcome Trust
            Sanger Institute, CB10 1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900983635.1-RS_2024_05_11
            Annotation Date                   :: 05/11/2024 02:49:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,709
            CDSs (total)                      :: 1,652
            Genes (coding)                    :: 1,595
            CDSs (with protein)               :: 1,595
            Genes (RNA)                       :: 57
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 48
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 36 of 57
            Pseudo Genes (incomplete)         :: 21 of 57
            Pseudo Genes (internal stop)      :: 23 of 57
            Pseudo Genes (multiple problems)  :: 19 of 57
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:58:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 28879
            Orig. end                         :: 70055
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CAAHKK010000009.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..41176
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="T3PKS"
                     /region_number="1"
                     /rules="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /tool="antismash"
     cand_cluster    1..41176
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /kind="single"
                     /product="T3PKS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..41176
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="False"
                     /core_location="[20000:21176](-)"
                     /cutoff="20000"
                     /detection_rule="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /neighbourhood="20000"
                     /product="T3PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(20001..21176)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /neighbourhood="20000"
                     /product="T3PKS"
                     /protocluster_number="1"
     misc_feature    76..89
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.38"
                     /tool="antismash"
     gene            219..926
                     /locus_tag="E9649_RS05485"
                     /old_locus_tag="SAMEA3919117_01069"
     CDS             219..926
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990206.1"
                     /locus_tag="E9649_RS05485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01069"
                     /product="glycoside hydrolase family 73 protein"
                     /protein_id="WP_002990206.1"
                     /transl_table=11
                     /translation="MTKKKGKLVLISLFVLAACLGAYSAMRQSHKTSNVSAETIASSST
                     RHFIDEIGPTASTIGQERDLYASVMIAQAILESSNGKSSLSQAPYYNFFGIKGAYNGSS
                     VTMSTWEDDGNGNTYTIDQAFRAYPSIADSLNDYADLLSSSTYIGARKSNTLSYQDATA
                     ALTGLYATDTSYNLKLNNIIATYGLTAYDVANSSAQETGLATSGYVWNEYRRNYTDAET
                     LAVDEAWAKRMTY"
     gene            complement(983..>1300)
                     /locus_tag="E9649_RS05490"
                     /pseudo=""
     CDS             complement(983..>1300)
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /locus_tag="E9649_RS05490"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="IS3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="KCYDGTI"
     gene            complement(1883..2908)
                     /locus_tag="E9649_RS05505"
                     /old_locus_tag="SAMEA3919117_01071"
     CDS             complement(1883..2908)
                     /EC_number="3.4.22.-"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922160.1"
                     /locus_tag="E9649_RS05505"
                     /note="This family includes IgM or IgG-cleaving cysteine
                     proteases.; This family includes IgM or IgG-cleaving
                     cysteine proteases.; This family includes IgM or
                     IgG-cleaving cysteine proteases; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="SAMEA3919117_01071"
                     /product="IdeS/Mac family cysteine endopeptidase"
                     /protein_id="WP_002992557.1"
                     /transl_table=11
                     /translation="MRKRCYSTSAAVLAAVTLFALSVDRGVIADSFSANQEIRYSEVTP
                     YHVTSVWTKGVTPPAKFTQGEDVFRAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLH
                     WWFDQNKEKIEAYLKKHPDKQKIMFGDQELLDVRKVINTKGDQTNSELFNYFRDKAFPG
                     LSARRIGVMPDLVLDMFINGYYLNVYKTQTTDVNRTYQEKDRRGGIFDAVFTRGDQSKL
                     LTSRHDFKEKTLKEISDLIKKELTEGKALGLSHTYANVRINHVINLWGADFDSNGNLKA
                     IYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDSWNQT
                     N"
     misc_feature    complement(2931..2944)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.62"
                     /tool="antismash"
     misc_feature    2975..2988
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.36"
                     /tool="antismash"
     gene            3411..3587
                     /locus_tag="E9649_RS05510"
                     /old_locus_tag="SAMEA3919117_01072"
     CDS             3411..3587
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="E9649_RS05510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMEA3919117_01072"
                     /product="nucleoside-diphosphate kinase"
                     /protein_id="WP_002985013.1"
                     /transl_table=11
                     /translation="MIKLYGFKYGLVGEVLRRIERLGFTFERLELRQASSKYLAKHDEA
                     LVINLFILDLKLT"
     gene            3815..4195
                     /locus_tag="E9649_RS05515"
                     /old_locus_tag="SAMEA3919117_01073"
     CDS             3815..4195
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985011.1"
                     /locus_tag="E9649_RS05515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01073"
                     /product="DUF1149 family protein"
                     /protein_id="WP_002985011.1"
                     /transl_table=11
                     /translation="MQLVREKEFVNQYHYDARNLEWEKENGTPETNFEVTFQLIDKDEQ
                     QKETVIVSVLQFVIVKEEFVISGVISQMVRILDRLVDKPSEFTQEEVESLAAPLLDMVK
                     RLTYEVTEIALDRPGIHLEFKN"
     gene            4195..5043
                     /locus_tag="E9649_RS05520"
                     /old_locus_tag="SAMEA3919117_01074"
     CDS             4195..5043
                     /GO_function="GO:0005504 - fatty acid binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985007.1"
                     /locus_tag="E9649_RS05520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01074"
                     /product="DegV family protein"
                     /protein_id="WP_002990194.1"
                     /transl_table=11
                     /translation="MKLAVITDSTATLPTDLKQDKAIFSLDIPVIIDDETYFEGRNLSI
                     DDFYQKMADSQNLPKTSQPSLSELDNLLGLLSSKGYTHVIGLFLAGGISGFWQNIQFLA
                     EEHPEIEMAFPDSKITSAPLGSMVKNVLDWSRQGMTFQAILNKLQEQIDGTTAFIMVDD
                     LNHLVKGGRLSNGSALLGNLLSIKPILRFDEEGKIVVYEKVRTEKKAMKRLVEILNDLI
                     ADGQYNVSIIHSKAQDKADYLKRLLQDSGYQYDIEEVHFGAVIATHLGEGAIAFGVTPR
                     L"
     gene            5168..6376
                     /locus_tag="E9649_RS05525"
                     /old_locus_tag="SAMEA3919117_01075"
     CDS             5168..6376
                     /EC_number="2.7.7.72"
                     /GO_function="GO:0016779 - nucleotidyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0001680 - tRNA 3'-terminal CCA addition
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880307.1"
                     /locus_tag="E9649_RS05525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01075"
                     /product="CCA tRNA nucleotidyltransferase"
                     /protein_id="WP_168389175.1"
                     /transl_table=11
                     /translation="MKLMTMPSEFQKALPILTKIKEAGYEAYFVGGSVRDVLLERPIHD
                     VDIATSSYPEETKAIFNRTVDVGIEHGTVLVLENGGEYEITTFRTEDVYVDYRRPSQVS
                     FVRSLEEDLKRRDFTVNALALDENGQVIDKFRGLIDLEQKRLRAVGKAEERFEEDALRI
                     MRGFRFAASLDFDIEAATFEAMRSHSPLLEKISVERSFTEFDKLLMAPHWRKGISAMIA
                     CQAYDYLPGLKQQEAGLNHLIVSLKDNFTFSDHHQAWAYVMISLAIEDPKSFLKAWKTS
                     NDFQRYVTKLIALYRIRQERSFEKLDIYQYGKEMASLVEGLRKAQSLSVDMDHIEALDQ
                     ALAIHNKYDIVLNGSHLIKDFGMEPGPQLGLMLEKVELAIVEGRLDNDFTTIEAFVREE
                     LAT"
     gene            6373..8250
                     /locus_tag="E9649_RS05530"
                     /old_locus_tag="SAMEA3919117_01076"
     CDS             6373..8250
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922163.1"
                     /locus_tag="E9649_RS05530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01076"
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="WP_136047823.1"
                     /transl_table=11
                     /translation="MSHFLVEKLTKTVGDKTVFQDISFIIHDFDRIGLIGVNGTGKTTL
                     LDVLSGRLGFDGDHSPFSKANDYKIAYLTQDPEFNDAASVLDTVLSSDVKAIQLIRQYE
                     LLMADYTEDKQETLESLMSEMDRLDAWSIESDVKTVLSKLGITDLEQKVGDLSGGMRRR
                     VQLAQVLLGAADLLLLDEPTNHLDIDTIAWLTTYLKTAKKTVLFITHDRYFLDHVATRI
                     FELDKAGLTEYQGNYQDYVRLKAEQDERDAANLHKKKQLYKQELAWMRTQPQARATKQQ
                     ARINRFTDLKKEVHQDSSADKLEMAFETSRIGKKVIHFEDLSFAYGDRQLIKDFNLIIQ
                     NKDRIGIVGDNGVGKSTLLNLINGDLEPTSGKLDIGDTIRVGYFSQQLKDMDETKRVIN
                     YLQEVADEVKTSVGTTSISELLEQFLFPRSSHGTLIAKLSGGEKKRLYLLKLLIEKPNV
                     LLLDEPTNDLDIATLTVLENFLANFAGPVITVSHDRYFLDKVATKILAFEEGDIRVFYG
                     NYSDYLDEKVFEKETVEADLVKTTVTEEVPLPQKEERKRMSYLEKQEWAQIEDKIATIE
                     ANIEEIENQMLTVVSDYDQLAQLQKELDQHNNDLLLAYERFEYLSGLDI"
     gene            complement(<8348..>8425)
                     /locus_tag="E9649_RS08900"
                     /pseudo=""
     CDS             complement(<8348..8425)
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611513.1"
                     /locus_tag="E9649_RS08900"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="IS3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MDYCNNKRIKIKRKGLSPLQHRTKSF"
     gene            8668..8886
                     /locus_tag="E9649_RS09045"
     CDS             8668..8886
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002995561.1"
                     /locus_tag="E9649_RS09045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_014407501.1"
                     /transl_table=11
                     /translation="MALLFYYYVRKNQVKKLSQLKNLTEIFRKFIILTINNISAIKVFQ
                     TAGVLFGPVKVANARESSIWFENLTKQ"
     gene            9142..9552
                     /locus_tag="E9649_RS05540"
                     /old_locus_tag="SAMEA3919117_01077"
     CDS             9142..9552
                     /EC_number="3.5.1.88"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1275: peptide deformylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017671.1"
                     /locus_tag="E9649_RS05540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01077"
                     /product="peptide deformylase"
                     /protein_id="WP_002984994.1"
                     /transl_table=11
                     /translation="MIREIITDHFLLQQKAQVAKKEDLWIGQDLQDTLAFYRQECLGMA
                     ANMIGEQKRIVIVSMGFIDLVMFNPVMVSKKGIYQTKESCLSLSGYRKTQRYDKITVEY
                     LDHNWRPKRLSLTGLTAQICQHELDHLEGILI"
     gene            complement(9634..11646)
                     /locus_tag="E9649_RS05545"
                     /old_locus_tag="SAMEA3919117_01078"
     CDS             complement(9634..11646)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1283: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888982.1"
                     /locus_tag="E9649_RS05545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01078"
                     /product="bifunctional metallophosphatase/5'-nucleotidase"
                     /protein_id="WP_136047824.1"
                     /transl_table=11
                     /translation="MKKYFILKSSVLSILTSFTLLVTDVQADQVDVQFLGVNDFHGALD
                     NTGTAYTPSGKIPNAGTAAQLGAYMDDAEIDFKQANQDGTSIRVQAGDMVGASPANSAL
                     LQDEPTVKVFNKMKFEYGTLGNHEFDEGLDEFNRIMTGQAPDPESTINDITKQYEHEAS
                     HQTIVIANVIDKKTNDIPYGWKPYAIKDIAINDKIVKIGFIGVVTTEIPNLVLKQNYEH
                     YQFLDVAETIAKYAKELQEQHVHAIVVLAHVPATSKDGVVDHEMATVMEKVNQIYPEHS
                     IDIIFAGHNHQYTNGTIGKTRIVQALSQGKAYADVRGTLDTDTNDFMTTPSANVVAVAP
                     GIKTENSDIKAIINHANDIVKTVTERKIGTATNSSTISKTENIDKESPVGNLVTTAQLT
                     IAKKTFPTVDFAMTNNGGIRSDLVVKNDRTITWGAAQAVQPFGNILQVIQMTGQHIYDV
                     LNQQYDENQTYFLQMSGLTYTYTDNDPKNSDTPFKIVKVYKDNGEEINLTTTYTVVVND
                     FLYGGGDGFSAFKKAKLIGAINTDTEAFITYITNLEASGKTVNATIKGVKNYVTSNLES
                     STKVNSAGKHSIISKVFRNRDGNIVSSEVISDLLTSTENTNNSLGKKETTTNKNTISSS
                     TLPITGDNYKMSPIMTILALISLGGLNAFIKKRKS"
     misc_feature    11622..11635
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.33"
                     /tool="antismash"
     misc_feature    11637..11650
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.93"
                     /tool="antismash"
     misc_feature    complement(11638..11651)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.3"
                     /tool="antismash"
     gene            11866..12516
                     /locus_tag="E9649_RS05550"
                     /old_locus_tag="SAMEA3919117_01079"
     CDS             11866..12516
                     /GO_process="GO:0015969 - guanosine tetraphosphate
                     metabolic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984988.1"
                     /locus_tag="E9649_RS05550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01079"
                     /product="GTP pyrophosphokinase family protein"
                     /protein_id="WP_002984988.1"
                     /transl_table=11
                     /translation="MKERLEHYSTSSIYSGFEVYLPLVLQTITDVIIAENIKSKKETGF
                     KLYEHFTSRIKSEASMIEKCQRKQLPLTSKSALKIIKDSIGIRIICGFIDDIYRMVDLL
                     KSIPGMSVNTEKDYILNAKPNGYRSYHLILELETHFPDILGEKKGCYFIEVQLRTIAQD
                     SWASLEHQMKYKHQVANAEMITRELKRCADELASCDVTMQTIRQLIQETTEEE"
     gene            12519..13187
                     /locus_tag="E9649_RS05555"
                     /old_locus_tag="SAMEA3919117_01080"
     CDS             12519..13187
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984985.1"
                     /locus_tag="E9649_RS05555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01080"
                     /product="response regulator transcription factor"
                     /protein_id="WP_002984985.1"
                     /transl_table=11
                     /translation="MKILLAEDEWQMSNVLTTAMTHQGYDVDVVFNGQEAIDKAKDNAY
                     DIMILDIMMPIKSGIEALKEIRASGNCSHIIMLTAMAEINDRVTGLDAGADDYLTKPFS
                     LKELLARLRSMERRVESFTPQVLQFAGVTLNINEQELSAGNAIRLASKEGKLMAFLMLN
                     QGKYLDTKTLYQHVWSDQEDYDTSIVWVYISYLRQKLLAIQANVIIAGDKDTSYCLLEK
                     "
     gene            13196..14428
                     /locus_tag="E9649_RS05560"
                     /old_locus_tag="SAMEA3919117_01081"
     CDS             13196..14428
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888981.1"
                     /locus_tag="E9649_RS05560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01081"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_010922165.1"
                     /transl_table=11
                     /translation="MFNRIRIRFIMIASIAIFIILSSIVGIINTARCYQSQQEINRILH
                     LISSNKGKLPGTTESSKRLGTKLSEDSLSQFRYYSVIFNANGHLLSSNTANISALDREE
                     AQYFARLFAKSGEEKGSYRHQDSVYSYLITQLPNEEKLVVILDTTFYFRSVGDLLAVSV
                     MLAFGGFIFFVVLVSLFSGMVIKPFVQNYEKQRRFITNAGHELKTPLAIISANNELVEL
                     MTGESEWTKSTSDQVKRLTGLINQMITLARLEEQPDVVLHMVDFSAIAQDAAEDFKSLV
                     LKDGKRFDLTIQPNIMIKAEEKSLFELVTILVDNANKYCDPKGLVKVSLTTIGRRRKRA
                     KLEVSNTYLEGKSIDYSRFFERFYREDESHNSKEKGYGIGLSMAESMVKLFKGTITVNY
                     KNDAIVFTVVI"
     gene            14721..15599
                     /gene="mvk"
                     /locus_tag="E9649_RS05565"
                     /old_locus_tag="SAMEA3919117_01082"
     CDS             14721..15599
                     /EC_number="2.7.1.36"
                     /GO_function="GO:0004496 - mevalonate kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016126 - sterol biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0019287 - isopentenyl diphosphate
                     biosynthetic process, mevalonate pathway [Evidence IEA]"
                     /codon_start=1
                     /gene="mvk"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054375.1"
                     /locus_tag="E9649_RS05565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01082"
                     /product="mevalonate kinase"
                     /protein_id="WP_011284695.1"
                     /transl_table=11
                     /translation="MNENIGYGKAHSKIILIGEHAVVYGYPAIALPLTDIEVVCHIFPA
                     DKPLVFDFYDTLSTAIYAALDYLQRLQEPIAYEIVSQVPQKRGMGSSAAVSIAAIRAVF
                     SYCQEPLSDDLLEILVNKAEIIAHTNPSGLDAKTCLSDHAIKFIRNIGFETIEIALNGY
                     LVIADTGIHGHTREAVNKVAQFEETNLPYLAKLGALTQALERAINQKNKVAIGQLMTQA
                     HSALKAIGVSISKADQLVEAALRAGALGAKMTGGGLGGCMIALADTKDMAEKISHRLKE
                     EGAVNTWIQML"
     gene            15581..16525
                     /gene="mvaD"
                     /locus_tag="E9649_RS05570"
                     /old_locus_tag="SAMEA3919117_01083"
     CDS             15581..16525
                     /EC_number="4.1.1.33"
                     /GO_function="GO:0004163 - diphosphomevalonate
                     decarboxylase activity [Evidence IEA]"
                     /GO_process="GO:0019287 - isopentenyl diphosphate
                     biosynthetic process, mevalonate pathway [Evidence IEA]"
                     /codon_start=1
                     /gene="mvaD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888980.1"
                     /locus_tag="E9649_RS05570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01083"
                     /product="diphosphomevalonate decarboxylase"
                     /protein_id="WP_014407503.1"
                     /transl_table=11
                     /translation="MDPNVITVTSYANIAIIKYWGKENQAKMIPSTSSISLTLENMFTT
                     TSVSFLPDTATSDQFYINGVLQNDEEHTKISAIIDQFRQPGQAFVKMETQNNMPTAAGL
                     SSSSSGLSALVKACDQLFDTQLDQKALAQKAKFASGSSSRSFFGPVAAWDKDSGAIYKV
                     ETDLKMAMIMLVLNAAKKPISSREGMKLCRDTSTTFDQWVEQSAIDYQHMLTYLKTNNF
                     EKVGQLTEANALAMHATTKTANPPFSYLTKESYQAMEAVKELRQEGFACYFTMDAGPNV
                     KVLCLEKDLAQLAERLGKNYRIIVSKTKDLPDV"
     gene            16518..17531
                     /locus_tag="E9649_RS05575"
                     /old_locus_tag="SAMEA3919117_01084"
     CDS             16518..17531
                     /EC_number="2.7.4.2"
                     /GO_function="GO:0004631 - phosphomevalonate kinase
                     activity [Evidence IEA]"
                     /GO_process="GO:0016126 - sterol biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0019287 - isopentenyl diphosphate
                     biosynthetic process, mevalonate pathway [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635411.1"
                     /locus_tag="E9649_RS05575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01084"
                     /product="phosphomevalonate kinase"
                     /protein_id="WP_136047825.1"
                     /transl_table=11
                     /translation="MSNYCVQTGGKLYLTGEYAILTPGQKALIHFIPLMMTAEISPAAH
                     IQLASDMFAHKAGMTPDASYALIQATVKTFADYLGQSIDQLEPFSLIVTGKMERDGKKF
                     GIGSSGSVTLLTLKALSAYYQITLTPELLFKLAAYTLLKQGDNGSMGDIACIAYQTLVA
                     YTSFDREQVSNWLQTMPLKKLLVKDWGYHIQVIQPALPCDFLVGWTKIPAISRQMIQQV
                     TASITPAFLRTSYQLTQSAMVALQEGHKEELKKSLAGASHLLKELHPAIYHPKLVTLVA
                     ACQKQDAVAKSSGSGGGDCGIALAFNQNARDILISKWQEADIALLYQERWGENDQP"
     gene            17518..18507
                     /gene="fni"
                     /locus_tag="E9649_RS05580"
                     /old_locus_tag="SAMEA3919117_01085"
     CDS             17518..18507
                     /EC_number="5.3.3.2"
                     /GO_function="GO:0004452 - isopentenyl-diphosphate
                     delta-isomerase activity [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="fni"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984966.1"
                     /locus_tag="E9649_RS05580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01085"
                     /product="type 2 isopentenyl-diphosphate Delta-isomerase"
                     /protein_id="WP_010922169.1"
                     /transl_table=11
                     /translation="MTNRKDDHIKYALKYQSPYNAFDDIELIHHSLPSYDLSDIDLSTH
                     FAGQDFDFPFYINAMTGGSQKGKAVNEKLAKVAAATGIVMVTGSYSAALKNPNDDSYRL
                     HEVADNLKLATNIGLDKPVALGQQTVQEMQPLFLQVHVNVMQELLMPEGERVFHTWKKH
                     LAEYASQIPVPVILKEVGFGMDVNSIKLAHDLGIQTFDISGRGGTSFAYIENQRGGDRS
                     YLNDWGQTTVQCLLNAQGLMDQVEILASGGVRHPLDMIKCFVLGARAVGLSRTVLELVE
                     KYPTERVIAIVNGWKEELKIIMCALDCKTIKELKGVDYLLYGRLQQVN"
     gene            complement(18737..20014)
                     /locus_tag="E9649_RS05585"
                     /old_locus_tag="SAMEA3919117_01086"
     CDS             complement(18737..20014)
                     /EC_number="1.1.1.88"
                     /GO_function="GO:0004420 - hydroxymethylglutaryl-CoA
                     reductase (NADPH) activity [Evidence IEA]"
                     /GO_process="GO:0016054 - organic acid catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1187: hydroxymethylglutaryl-CoA reductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880299.1"
                     /locus_tag="E9649_RS05585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01086"
                     /product="hydroxymethylglutaryl-CoA reductase, degradative"
                     /protein_id="WP_002984963.1"
                     /transl_table=11
                     /translation="MTKTNLNWSGFSKKTFEERLQLIEKFKLLNAENLNQLKTDVLLPI
                     QTANQMTENVLGRLALPFSIAPDFLVNGSTYQMPFVTEEPSVVAAASFAAKLIKRSGGF
                     KAQTLNRQMIGQIVLYDIDQIDNAKAAILHKTKKLIALANKAYPSIVKRGGGARTIHLE
                     EKGEFLIFYLTVDTQEAMGANMVNTMMEALVPDLTRLSKGHCLMAILSNYATESLVTTS
                     CEIPVRLLDRDKTKSLQLAQKIELASRLAQVDPYRATTHNKGIFNGIDAVVIATGNDWR
                     AIEAGAHAYASRNGSYQGLSQWHFDQDKQVLLGQMTLPMPIASKGGSIGLNPTVSIAHD
                     LLNQPDAKTLAQLIASVGLAQNFAALKALTSSGIQAGHMKLHAKSLALLAGATQDEIAP
                     LVNALLADKPINLEKAHFYLSQLRQS"
     gene            complement(20001..21176)
                     /locus_tag="E9649_RS05590"
                     /old_locus_tag="SAMEA3919117_01087"
     CDS             complement(20001..21176)
                     /EC_number="2.3.3.10"
                     /GO_function="GO:0004421 - hydroxymethylglutaryl-CoA
                     synthase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T3PKS:
                     Chal_sti_synt_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1043: hydroxymethylglutaryl-CoA synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002993959.1"
                     /locus_tag="E9649_RS05590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01087"
                     /product="hydroxymethylglutaryl-CoA synthase"
                     /protein_id="WP_136047826.1"
                     /sec_met_domain="Chal_sti_synt_N (E-value: 4.1e-08,
                     bitscore: 25.5, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIGIDKIGFATSQYVLKLEDLALARQVDPAKFSQGLLIESFSVA
                     PITEDIITLAASAADQILTDEDRAKIDMVILATESSTDQSKASAIYVHHLVGIQPFARS
                     FEVKQACYSATAALDYAKLHVASKPDSRVLVIASDIARYGVGSPGESTQGSGSIALLVT
                     ADPRILALNEDNVAQTRDIMDFWRPNYSFTPYVDGIYSTKQYLNCLETTWQAYQKRENL
                     QLSDFAAVCFHIPFPKLALKGLNNIMDNTVPPEHREKLIEAFQASITYSKQIGNIYTGS
                     LYLGLLSLLENSKVLQSGDKIGFFSYGSGAVSEFYSAQLVAGYDKMLMTNRQALLDQRT
                     RLSVSKYEDLFYEQVQLDDNGNANFDIYLTGKFALTAIKEHQRIYRTNDKN"
     gene            21385..22224
                     /locus_tag="E9649_RS05595"
                     /old_locus_tag="SAMEA3919117_01088"
     CDS             21385..22224
                     /EC_number="2.1.1.45"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003011065.1"
                     /locus_tag="E9649_RS05595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01088"
                     /product="thymidylate synthase"
                     /protein_id="WP_002990167.1"
                     /transl_table=11
                     /translation="MTKADQIFKANIQKIINEGSLSEQARPKYKDGRTAHSKYITGAFA
                     EYDLAKGEFPITTLRPIPIKSAIKELFWIYQDQSNSLDVLEAKYNVHYWNEWEVDQTRT
                     IGQRYGAVVKKHDIISKILKQLAENPWNRRNVISLWDYEAFEETKGLLPCAFQIMFDVR
                     RVGEDLYLDASLTQRSNDILVAHHINAMQYVALQMMFAKHFGWKIGKFFYFVNNLHIYD
                     NQFDQAQELLKRQPVASQPKLVLNVPDGTNFFDIKPDDFELQNYDPVKPQLHFDLAI"
     misc_feature    21415..21429
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 23.77"
                     /tool="antismash"
     gene            22304..22801
                     /locus_tag="E9649_RS05600"
                     /old_locus_tag="SAMEA3919117_01089"
     CDS             22304..22801
                     /EC_number="1.5.1.3"
                     /GO_function="GO:0004146 - dihydrofolate reductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005542 - folic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984955.1"
                     /locus_tag="E9649_RS05600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01089"
                     /product="dihydrofolate reductase"
                     /protein_id="WP_136047827.1"
                     /transl_table=11
                     /translation="MTKEIIAIWAEDEAGLIGVAGKLPWYLPKELEHFKKTTLHQAILM
                     GRMTFEGMNCKRLPQRQTLVMTRNRDYQVDEVLTMTSIEKVLEWYHAQDKTLYIIGGNK
                     VLEAFNGYFDRIIKTVIHHRFKGDTYRPNLDFSHFTQESQTFYARDAKNPYDFTVTALK
                     HK"
     gene            22821..22991
                     /locus_tag="E9649_RS05605"
                     /old_locus_tag="SAMEA3919117_01090"
     CDS             22821..22991
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002302775.1"
                     /locus_tag="E9649_RS05605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01090"
                     /product="hypothetical protein"
                     /protein_id="WP_002990165.1"
                     /transl_table=11
                     /translation="MQRSIFGVFTAFLCVICVLCAIPAFKKNRYGLGSLFLLNAFTNLV
                     NSIHAFYGTLF"
     gene            23121..24350
                     /gene="clpX"
                     /locus_tag="E9649_RS05610"
                     /old_locus_tag="SAMEA3919117_01091"
     CDS             23121..24350
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="clpX"
                     /gene_functions="other (smcogs) SMCOG1223: ATPase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984948.1"
                     /locus_tag="E9649_RS05610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01091"
                     /product="ATP-dependent Clp protease ATP-binding subunit
                     ClpX"
                     /protein_id="WP_002984948.1"
                     /transl_table=11
                     /translation="MAGSRTNDIKVYCSFCGKSQDDVKKIIAGNNVFICNECVALSQEI
                     IKEELAEEVLADLTEVPKPKELLDVLNQYVVGQDRAKRALSVAVYNHYKRVSFTESRDD
                     DDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATSLTEAGYVGEDVENILLK
                     LIQAADYNVERAERGIIYVDEIDKIAKKGENVSITRDVSGEGVQQALLKIIEGTVASVP
                     PQGGRKHPNQEMIQIDTKNILFIVGGAFDGIEEIVKQRLGEKVIGFGQNSRKIDDNASY
                     MQEIISEDIQKFGLIPEFIGRLPVVAALEQLNTSDLIQILTEPRNALVKQYQALLSYDG
                     VELAFDKEALEAIANKAIERKTGARGLRSIIEETMLDIMFEIPSQEDVTKVRITKAAVE
                     GKSKPVLETA"
     gene            24360..24959
                     /gene="yihA"
                     /locus_tag="E9649_RS05615"
                     /old_locus_tag="SAMEA3919117_01092"
     CDS             24360..24959
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0043022 - ribosome binding [Evidence IEA]"
                     /GO_process="GO:0042254 - ribosome biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="yihA"
                     /gene_functions="other (smcogs) SMCOG1227: ribosome
                     biogenesis GTP-binding protein YsxC"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054379.1"
                     /locus_tag="E9649_RS05615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01092"
                     /product="ribosome biogenesis GTP-binding protein
                     YihA/YsxC"
                     /protein_id="WP_011184414.1"
                     /transl_table=11
                     /translation="MAEEQVLNTHNASILLSAANKSHYPQDDLPEIALAGRSNVGKSSF
                     INTILGRKNLARTSSKPGKTQLLNFFNIDNKLRFVDVPGYGYAKVSKSERAKWGKMIEE
                     YLTSRDNLRAVVSLVDLRHAPSKEDIQMYDFLKYYDIPVIVVATKADKIPRGKWNKHES
                     VVKKALNFDKSDTFIVFSSVERIGIDDSWDAILEQV"
     gene            25107..25850
                     /locus_tag="E9649_RS05620"
                     /old_locus_tag="SAMEA3919117_01093"
     CDS             25107..25850
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984942.1"
                     /locus_tag="E9649_RS05620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01093"
                     /product="hypothetical protein"
                     /protein_id="WP_002984942.1"
                     /transl_table=11
                     /translation="MTQVAQGRSKGKSLLCHQCNALFVFIIFLILLAVLFGVRYRNSSI
                     EGIWRTTSIDQKLGDDFAKRLTGLHQSPLIDDSLLTSSQMILTVKNNNVDLSFSVQVER
                     DIFVKRLAAYHQNELLKTLKENHLVVGDLSSKERQIIENSMPASHELEMILDQAFEKLA
                     SQIGGKYNQKTGHLSAVVLKGKVNRILHTIDIKEEVAAGHTSFSKGLLTPNGYFDYTRF
                     GKKLELLGDEKIIFKKALKKSPSSV"
     gene            complement(25908..28007)
                     /locus_tag="E9649_RS05625"
                     /old_locus_tag="SAMEA3919117_01094"
     CDS             complement(25908..28007)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1223: ATPase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922175.1"
                     /locus_tag="E9649_RS05625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01094"
                     /product="ATP-dependent Clp protease ATP-binding subunit"
                     /protein_id="WP_136047828.1"
                     /transl_table=11
                     /translation="MTHFSGKDPFVNMDDIFNQLMANMGGYRSENPRYLVNGREITPEE
                     FQDYRQTGQLPVATTKATNSQMLTPKADSVLTQLGTNLTQEARQGHLDPVIGRNKEIQD
                     TAEILARRTKNNPVLVGDAGVGKTAVIEGLAQAIVNGDVPAAIKNKEIVSIDISSLEAG
                     TQYRGSFEETIQNLIQEVKEAGNIILFFDEIHQIVGAGATSSDSGSKGLADILKPALSR
                     GELTLIGATTQDEYRNTILKNAALARRFNEVKVNAPSAEDTFHILMCIRNLYEQHHHIT
                     LPDNVLKAAVDYSIQYIPQRSLPDKAIDLLDMTAAHLAAQHPVTDLKTLETEIAKQKES
                     QEKAVAKEDFEKALAAKTRIETLQKQIEQHNQSQNVTATVNDIAESVERLTGIPVSNMG
                     TNDLERLKGISSRLKSHVIGQDEAVAAVARAIRRNRAGFDDGNRPIGSFLFVGPTGVGK
                     TELAKQLALDLFGSKDAIIRLDMSEYNDRTAVSKLIGTTAGYVGYDDNNNTLTERVRRN
                     PYAIVLLDEIEKADPQIITLLLQVLDDGRLTDGQGNTINFKNTVIIATSNAGFGQQDTE
                     TSESNIMDRIAPYFRPEFLNRFNSIIKFNHLQKENLEEIVDLMLAEVNQTTAKKGISLT
                     IADDAKAHLIDLGYNHAMGARPLRRIIEQEIRDRITDYYLDHPDVKKLQAILKEGQLVI
                     RQNDQ"
     misc_feature    28138..28151
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 22.77"
                     /tool="antismash"
     gene            28386..29069
                     /gene="rpiA"
                     /locus_tag="E9649_RS05630"
                     /old_locus_tag="SAMEA3919117_01095"
     CDS             28386..29069
                     /EC_number="5.3.1.6"
                     /GO_function="GO:0004751 - ribose-5-phosphate isomerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009052 - pentose-phosphate shunt,
                     non-oxidative branch [Evidence IEA]"
                     /codon_start=1
                     /gene="rpiA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014623011.1"
                     /locus_tag="E9649_RS05630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01095"
                     /product="ribose-5-phosphate isomerase RpiA"
                     /protein_id="WP_020905094.1"
                     /transl_table=11
                     /translation="MEALKKIAGVTAAQYVTDGMTIGLGTGSTAYYFVEEIGRRVKQEG
                     LQVVGVTTSSVTSKQAEGLGIPLKSIDDIDSIDLTVDGADEVDKDFNGIKGGGAALLME
                     KIVATPTKEYIWVVDASKMVEHLGAFKLPVEVVQYGADRLFRVFEKAGYKPSFRMKGDS
                     RLVTDMQNYIIDLDLGCIKDPVAFGHLLDGTVGVVEHGLFNGMVDKVIVASKDGVTVLE
                     APKAS"
     gene            29146..30357
                     /locus_tag="E9649_RS05635"
                     /old_locus_tag="SAMEA3919117_01096"
     CDS             29146..30357
                     /EC_number="5.4.2.7"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008973 - phosphopentomutase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009117 - nucleotide metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0043094 - cellular metabolic compound
                     salvage [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184417.1"
                     /locus_tag="E9649_RS05635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01096"
                     /product="phosphopentomutase"
                     /protein_id="WP_136047829.1"
                     /transl_table=11
                     /translation="MSKFNRIHLVVLDSVGIGAAPDADKFFNAGVADTDSDTLGHISET
                     AGLSVPNMAKIGLGNISRPIPLKTVPTEDNPTGYVTKLEEVSLGKDTMTGHWEIMGLNI
                     TEPFDTFWNGFPEEILTKIEEFSGRKIIREANKPYSGTAVIDDFGPRQIETGELIVYTS
                     ADPVLQIAAHEDIIPVEELYKICEYARSITLERPALLGRIIARPYVGEPGNFTRTANRH
                     DYAVSPFQDTVLNKLADAGVPTYTVGKINDIFNGSGITNDMGHNKSNSHGIDTLIKTLQ
                     LPEFTKGFSFTNLVDFDANFGHRRDPEGYRDCLHEFDNRLPEIIANMKEDDLLLITADH
                     GNDPTYAGTDHTREYIPLLAYSASFTGNGLIPQGHFADISATVAENFEVDTAMIGESFL
                     GHLK"
     gene            30373..30828
                     /gene="arsC"
                     /locus_tag="E9649_RS05640"
                     /old_locus_tag="SAMEA3919117_01097"
     CDS             30373..30828
                     /EC_number="1.20.4.1"
                     /GO_function="GO:0008794 - arsenate reductase
                     (glutaredoxin) activity [Evidence IEA]"
                     /GO_process="GO:0046685 - response to arsenic-containing
                     substance [Evidence IEA]"
                     /codon_start=1
                     /gene="arsC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922177.1"
                     /locus_tag="E9649_RS05640"
                     /note="This arsenate reductase requires both glutathione
                     and glutaredoxin to convert arsenate to arsenite, after
                     which the efflux transporter formed by ArsA and ArsB can
                     extrude the arsenite from the cell, providing resistance.;
                     This arsenate reductase requires both glutathione and
                     glutaredoxin to convert arsenate to arsenite, after which
                     the efflux transporter formed by ArsA and ArsB can extrude
                     the arsenite from the cell, providing resistance; Derived
                     by automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01097"
                     /product="arsenate reductase (glutaredoxin)"
                     /protein_id="WP_136047830.1"
                     /transl_table=11
                     /translation="MEEITIYHNPNCGTSRNVLAMIRHAGIEPTIIEPTIIEYLQTPPN
                     RETLIELLQSMGISARELLRTNVPEFEAHGLANQAVAEKDVINAMLTDPILINRPIVVT
                     RKEVKLCRPSETLLDILPVPLPSPYMKEDGESVNPIEVKGEKDVIDD"
     gene            30812..31621
                     /locus_tag="E9649_RS05645"
                     /old_locus_tag="SAMEA3919117_01098"
     CDS             30812..31621
                     /EC_number="2.4.2.1"
                     /GO_function="GO:0004731 - purine-nucleoside phosphorylase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009116 - nucleoside metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015647060.1"
                     /locus_tag="E9649_RS05645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01098"
                     /product="purine-nucleoside phosphorylase"
                     /protein_id="WP_009880955.1"
                     /transl_table=11
                     /translation="MSLMTKINETKDFLVTKGIETPEFGLILGSGLGELAEEVENAIVI
                     DYADIPNWGKSTVVGHAGKLVYGDLAGRKVLALQGRFHFYEGNPLEVVTFPVRVMKALG
                     CEGVLVTNAAGGIGYGPGTLMAITDHINMTGNNPLIGENLDEFGPRFPDMSDAYTKVYR
                     DKAHEVAEKMNIKLEDGVYMGLTGPTYETPAEIRAFKVLGADAVGMSTVPEVIVAAHSG
                     LKVLGISAITNFAAGFQSELNHEEVVEVTQHIKEDFKGLVKAILAEL"
     misc_feature    complement(31821..31834)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.2"
                     /tool="antismash"
     gene            32206..32919
                     /gene="deoD"
                     /locus_tag="E9649_RS05650"
                     /old_locus_tag="SAMEA3919117_01099"
     CDS             32206..32919
                     /EC_number="2.4.2.1"
                     /GO_function="GO:0004731 - purine-nucleoside phosphorylase
                     activity [Evidence IEA]"
                     /GO_process="GO:0043096 - purine nucleobase salvage
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="deoD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984928.1"
                     /locus_tag="E9649_RS05650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01099"
                     /product="purine-nucleoside phosphorylase"
                     /protein_id="WP_002990147.1"
                     /transl_table=11
                     /translation="MSIHISAKKGDIADKILLPGDPLRAKFIAENFLEDAVCFNEVRNM
                     FGYTGTYKGHRVSVMGTGMGMPSISIYARELIVDYGVKTLIRVGTAGAIDPEVHVRELV
                     LAQAAATNSNIIRNDFPEFDFPQIADFGLLDKAYHIAREMGVTTHVGNVLSSDVFYTNM
                     PERNMALGKLGVKAIEMEAAALYYLAAQHHVKALGIMTISDNLNDPTEDTTAEERQTTF
                     TDMMKVGLETLIAND"
     gene            32912..33700
                     /locus_tag="E9649_RS05655"
                     /old_locus_tag="SAMEA3919117_01100"
     CDS             32912..33700
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984926.1"
                     /locus_tag="E9649_RS05655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01100"
                     /product="hypothetical protein"
                     /protein_id="WP_002994010.1"
                     /transl_table=11
                     /translation="MTNNQTLDILLDVYAYNHAFRIAKALPNIPKTALYLLEMLKERRE
                     LNLAFLAEHAAENRTIEDQYHCSLWLNQSLEDEQIANYILDLEVKVKNGAIIDFVRSVS
                     PILYRLFLRLITSEIPNFKAYIFDTKNDQYDTWHFQAMLESDHEVFKAYLSQKQSRNVT
                     TKSLADMLTLTSLPQEIKDLVFLLRHFEKAVRNPLAHLIKPFDEEELHRTTHFSSQAFL
                     ENIITLATFSGVIYRREPFYFDDMNAIIKKELSLWRQSIV"
     gene            complement(33780..34685)
                     /locus_tag="E9649_RS05660"
                     /old_locus_tag="SAMEA3919117_01101"
     CDS             complement(33780..34685)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011284709.1"
                     /locus_tag="E9649_RS05660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01101"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_002984924.1"
                     /transl_table=11
                     /translation="MRIQQLHYIIKIVECGSMNEAAKQLFITQPSLSNAVKDLEMEMGI
                     TIFNRNPKGITLTKDGVEFLSYARQIIEQTSLLEDRYKNHNTGRELFSVSSQHYAFVVN
                     AFVSLLKRTDMTRYELFLRETRTWEIIDDVKNFRSEIGVLFINDYNRDVLTKLFDDNHL
                     TASPLFKAQPHIFVSKSNPLATKSLLSMDDLRDFPYLSYDQGIHNSFYFSEEMMSQMPH
                     NKSIVVSDRATLFNLMIGLDGYTVASGILNSNLNGDQIVAIPLDVPDEIDIVFIKHEKA
                     NLSKMGERFIEYLLEEVTFD"
     gene            34907..35443
                     /locus_tag="E9649_RS05665"
                     /old_locus_tag="SAMEA3919117_01102"
     CDS             34907..35443
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990141.1"
                     /locus_tag="E9649_RS05665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01102"
                     /product="hypothetical protein"
                     /protein_id="WP_002984923.1"
                     /transl_table=11
                     /translation="MNVTEQNSHQILIQKLLVSIHYLTLFRDELKLVERTPSILGGEFP
                     AHLVQSELGDIVAAIDTLDMQQRLIESTFWYEESAFKLMNKTLDIVDNWIKGVDHLIDL
                     CQSKEVFQIIIGDKRIRVFGVLSDVFSSLKVSALSLKEAPIPDVLYEHIQRVNLEEEAF
                     IKYYQSPKVPTGEFE"
     gene            35720..36412
                     /gene="pyrF"
                     /locus_tag="E9649_RS05670"
                     /old_locus_tag="SAMEA3919117_01104"
     CDS             35720..36412
                     /EC_number="4.1.1.23"
                     /GO_function="GO:0004590 - orotidine-5'-phosphate
                     decarboxylase activity [Evidence IEA]"
                     /GO_process="GO:0006207 - 'de novo' pyrimidine nucleobase
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0044205 - 'de novo' UMP biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="pyrF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984921.1"
                     /locus_tag="E9649_RS05670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01104"
                     /product="orotidine-5'-phosphate decarboxylase"
                     /protein_id="WP_136047831.1"
                     /transl_table=11
                     /translation="MKEDRPIIALDFSSFEETKAFLDLFPAEEKLYVKIGMELYYAQGP
                     DIVRYIKSLGHNVFLDLKLHDIPNTVRAAMAVLKELDIDMATVHAAGGVEMLKAAREGL
                     GQGPTLIAVTQLTSTSEDQMRGDQNIQTSLLESVLHYSKGAAKAQLDGVVCSAQEVEAI
                     KAVTPTGFTCLTPGIRPKGSNIGDQKRVMTPNQARRIGSDYIVVGRPITQAKDPVAAYQ
                     ATKAEWAG"
     gene            36470..37099
                     /gene="pyrE"
                     /locus_tag="E9649_RS05675"
                     /old_locus_tag="SAMEA3919117_01105"
     CDS             36470..37099
                     /EC_number="2.4.2.10"
                     /GO_function="GO:0004588 - orotate
                     phosphoribosyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009220 - pyrimidine ribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pyrE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922180.1"
                     /locus_tag="E9649_RS05675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01105"
                     /product="orotate phosphoribosyltransferase"
                     /protein_id="WP_002984920.1"
                     /transl_table=11
                     /translation="MTLASQIATQLLDIKAVYLKPEDPFTWASGIKSPIYTDNRVTLSY
                     PKTRDLIENGFVETIRAHFPEVEVIAGTATAGIPHGAIIADKMTLPFAYIRSKPKDHGA
                     GNQIEGRVLKGQKMVIIEDLISTGGSVLDAAAAASREGADVLGVVAIFTYELPKASQNF
                     KEAGIKLITLSNYTELIAVAKLQGYITNDGLHLLKKFKEDQVNWQQ"
     gene            37296..38750
                     /locus_tag="E9649_RS05680"
                     /old_locus_tag="SAMEA3919117_01106"
     CDS             37296..38750
                     /EC_number="3.5.1.4"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1105: amidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407508.1"
                     /locus_tag="E9649_RS05680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01106"
                     /product="amidase"
                     /protein_id="WP_011054384.1"
                     /transl_table=11
                     /translation="MTYQDATAMAIAVQTGQTTPLELVTQAIYKAKKLNPTLNAITSER
                     FEAALEEAKQRDFSGKPFAGVPIFLKDLGQELKGDLSTSGSKLFKNHHATKTDLFVKRL
                     EDLGFIILGRSNTPEFGFKNISDSQLHGPVSLPHDNTRNAGGSSGGAAALVSSGISALA
                     TASDGGGSIRIPASFNGLIGLKPSRGRMPVGPGSYRSWQGASVHFALTKSVRDTRNLLY
                     YLQMEQMESPFPLATLTKNSIYQSLQRPLTIAFYQRLSDGSPVSLDTAKALRQAVTWLR
                     EQGHQLVELEEFPVNMTEVIRHYYIMNSVETAAMFADIEDTFGRPMTKDDMETMTWAIY
                     QSGKDIPAWRYSQVLQKWDTYSATMASFHETYDLLLTFTTNTPAPKHGELVPDSKLMAN
                     LAQAEIFSSEEQFNLVETMFGKSLAINPYTALPNLTGQPAISLPTYETKEGLPMGIQLI
                     AAKGREDLLLGIAEQFEAAGLLKIPQ"
     gene            38868..39731
                     /locus_tag="E9649_RS05685"
                     /old_locus_tag="SAMEA3919117_01107"
     CDS             38868..39731
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091: glutamine-binding lipoprotein glnH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003061079.1"
                     /locus_tag="E9649_RS05685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01107"
                     /product="transporter substrate-binding domain-containing
                     protein"
                     /protein_id="WP_168389176.1"
                     /transl_table=11
                     /translation="MKKSVTLLSIGLASLLLAACAPHKSQKSSWETIKEKGVLKVATPG
                     TYQPTSFYNDNNELVGYEVDMVKEIGKRLNIKVKFVETGFDQAFTSVDSGRVDISLNNF
                     DITPKRQKKYNISTPYKYGVGGMIVRADGSSNMAKKDLSDWKGKKAAGASGTEYMKVAQ
                     KQGAELVTYDNVTGDVYLNDVANGRTDFIPNDYPAQKLFVDYMLSQNPNLNVKMSNVQY
                     NPTEQGIVMNKKDDSLKKKIDAVIKDMIKDGSLKKISETYYAGQDLTKPFGKDKKIPVI
                     DTKDVN"
     gene            39760..40410
                     /locus_tag="E9649_RS05690"
                     /old_locus_tag="SAMEA3919117_01108"
     CDS             39760..40410
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1096: polar amino
                     acid ABC transporter, inner membrane"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003057640.1"
                     /locus_tag="E9649_RS05690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA3919117_01108"
                     /product="amino acid ABC transporter permease"
                     /protein_id="WP_002990131.1"
                     /transl_table=11
                     /translation="MINIPLMKDSLGFVLSGLPYTLGISLLSFFTGLFLGLGLALLGRS
                     RQPLIHYLVRAYISIMRGVPMIVVLFVLYFGLPYYGLELPALLCAYLGFSMVSAAYISE
                     VFRSSIEAIDKGQWEAAKALGLPYALMVKKIILPQAFRIAVPPLGNVIIDMVKSSSLAA
                     MITVPDIFQNAKIIGGREWDYMSMYILVAFIYWIIAFLLERYQEFLENKLALV"
ORIGIN
        1 ccataccaaa ttaaatgaat tgattgaatg gtatcaactc actaattttg atggtctaat
       61 gaaatagtta tccacaattt taaaaaaaat cagaagaaat atgtcgattt caagacaaaa
      121 gttatcaatc tcattaaatt atctgtggaa aagttaattt aaacgttcgt gtgctataat
      181 agaaacatag aaaatgtata aaaaaggata tgtgaataat gacaaaaaag aaaggtaagc
      241 ttgtacttat cagtcttttt gttctagcag cttgtttagg agcttatagt gcaatgagac
      301 aatctcataa aacttcaaac gtgtcagctg agactatcgc cagttcttca acccgacatt
      361 ttattgatga aattggtcca actgctagta ctattggtca agaacgtgat ctttatgcgt
      421 ctgttatgat agcacaagcg attttagaat caagtaatgg taaatcaagt ctaagtcaag
      481 caccttatta taattttttc ggtattaagg gtgcctataa cggttcttct gtgacgatgt
      541 caacttggga agatgatggt aatggcaata cctatacgat tgatcaagcc tttagagctt
      601 atccaagtat tgcagactcc cttaatgact atgcagactt gctaagttct agcacttata
      661 taggtgctag aaaatcaaac acgctatcgt atcaagatgc tacagcagct ctaactggct
      721 tatacgctac agacaccagt tataacttaa aactaaataa tattattgca acctatggtt
      781 tgacggctta tgatgttgct aatagctcag ctcaagaaac tggtctagca acttcgggtt
      841 atgtttggaa tgagtatcgt cgtaattaca ctgatgcgga gaccctagca gttgatgagg
      901 cttgggctaa acgcatgact tattaatgta acactaacaa caatctgctt gcactgaccc
      961 caaaaaagct ggatactcta ttttaagtaa aggatttagt tctgtattgt acagaactaa
     1021 atccttttag ttttactttg atatgtttat cgttgtaata atcaatgtca tttgtaatcg
     1081 cttattctaa gtcttctagt gatttatagt tattctcata accatagaac atttctgact
     1141 ttaagatgcc aaagaaagat tccatcatgc tattgtcagg actgtttctt ttacgtgaca
     1201 tagacggacg aattccttta gagtttagga aatgatgata atagttgtgt tgatattgcc
     1261 aaccttgatc actctatcat atagttccat catagcattt atttggagat gcctttttcc
     1321 attattggtt taatgtgatt taagcaaggt tattagctaa acttaatgcc agacaaaaac
     1381 accccaatta ttagattttt tgtctaactt ttggggcgca attcaatctg agcagtttta
     1441 gatttggtat caatgttatt ataagtcaat tgatcatatt tatccaaagc ttttagctta
     1501 tttagtccaa agataaatat caaaatggct gaaatctttc atgtttatag tcttattgtc
     1561 tttatatttt ttaaagacat cagatctggc gctattgggt tttgcgtcat ataaattgat
     1621 tttttcatgt ttcctatttt tactgtgaat ttctaaactc cccccttata taaggagact
     1681 tagtcaaata aatttctttt gattccatca aaaattttct tattttaaaa tcgaactctt
     1741 gaatcgtaac aatatcctta tcgattttta taggatttat taatgttttt gctgttgccc
     1801 atctataaaa aaattccctg caatagtatt agtccttaga ataccatcat ctgttaaatg
     1861 taatctttct tattgatacg ctttaattgg tctgattcca actatcttgc cctgttgaaa
     1921 gtgtaaataa ccctagtact tgagcaccaa tattatcttc ttttatttct ttagcagaaa
     1981 tagctacttt tccagcggaa ttaacaccaa caaagtattt cttcatacca atagatgcat
     2041 tactatcaga gtctgttaca taaatagctt taaggttccc gttagaatca aagtcagctc
     2101 cccacaggtt tataacatgg ttgatgcgta cgttagcgta ggtgtgtgat aggcctagag
     2161 ccttgccttc ggttaactct ttcttaatga gatcactgat ttctttgaga gttttttctt
     2221 taaaatcatg acgacttgtc aatagcttac tttgatcacc tcttgtaaat acggcgtcaa
     2281 aaataccacc tcggcgatct ttctcttgat aggttctatt gacatcagta gtctgtgtct
     2341 tataaacatt taagtaatag ccattgataa acatatctaa aacaagatca ggcataactc
     2401 caattcggcg tgctgacaaa ccggggaaag ctttatctcg gaaataatta aaaagctcgc
     2461 tatttgtttg gtcaccttta gtattaataa cttttcttac atccaataat tcttgatcac
     2521 caaacatgat tttttgttta tctgggtgtt tttttagata tgcttcaatt ttttctttgt
     2581 tttgatcgaa ccaccagtga agcatattcc ctgctgtggc agccccgcaa agaagatcgt
     2641 cttttccatt gaatgttttg gtaatatcat accatccttg gttagcaaca taaggagcgc
     2701 gaaaaacatc ttcgccttga gtgaattttg ctggaggagt aactcctttg gtccaaacgg
     2761 aagtaacatg ataaggtgtt acttccgaat atctaatctc ttgattagca gaaaaactat
     2821 ctgctataac accacgatct accgatagag caaataaagt cactgctgcc aatactgcag
     2881 ctgaagttga atagcatctt tttctcataa gagtaccttt ttctatacaa ttttattata
     2941 aaaagattat atcatataga catctattgt tgcaattttt taaaataata tttaattttt
     3001 taaataattt ttaataaacg taaacaagcg attgacaatg gagatatcac aagagacaca
     3061 gtagtggttg tgcttaaaaa tggacggttt tttgatgata tgttgctgca tgaggaagtg
     3121 agcaatagga gagctgtgat agaagaaaga gaggaagaag cgttgatgaa attagacaaa
     3181 taaaaaaaga cctcatccag aagaggtcgt ggtataactg gggacgatag gttcaattga
     3241 taaaaaatct tgttagctta cgatctatgt tgttttgaat gcctttaact caacatcgtt
     3301 aatggatttt gagataaaaa aataaatcca atagtctggt actttcctat tttttgtctg
     3361 ttaaaacgtt tttattttat aatggataaa aggagaagaa gggcggagcg atgattaagc
     3421 tctatgggtt taagtatggg ttagttggag aggttttgcg gcggattgaa cgcctaggat
     3481 ttacgtttga gcgattagag ctaagacaag ctagttcaaa atacttggct aagcatgatg
     3541 aggccttggt gataaacctt tttatcctgg acttaaaact tacctgacca gtggttctgt
     3601 tttaattgag gtgcagtaca agaccactaa cgggtgtttt tttgatataa tgtcagtata
     3661 aggacgacta aatataaata ggtgaaaaaa tagatatctg ttcgagagat agcactgttt
     3721 aaaacgttat gcgaaaatag tagtttaggg gctactttaa taatcttcaa atctatgcta
     3781 taatggatca tattgatacc aaggagaata aaaaatgcaa ttagttcgtg aaaaagaatt
     3841 tgtcaaccag taccattatg atgctagaaa tttagagtgg gaaaaagaaa acggaacacc
     3901 agagaccaat tttgaagtga cttttcagtt gattgataaa gatgagcagc aaaaagaaac
     3961 agtaattgta tctgtattgc aatttgttat tgtcaaagaa gaatttgtta ttagtggggt
     4021 catctcacaa atggttcgta ttttagatcg tttagtggat aaaccaagcg aatttacgca
     4081 agaggaagtt gaatccttag ctgctccttt gctagacatg gttaagcgat tgacttatga
     4141 agtcacagaa attgccttgg atcgtccagg tattcatttg gagtttaaaa attaatgaaa
     4201 ttagcagtaa ttactgacag tacagcaaca ctaccaacag atctgaaaca agataaagct
     4261 atttttagcc ttgatatacc agttatcatt gacgatgaga cctattttga aggtcgaaat
     4321 ttgagtatag atgattttta tcaaaagatg gctgactccc aaaatcttcc caagacaagt
     4381 cagccaagtt tatctgaact agataatctt ttaggacttt tgtcttctaa gggctataca
     4441 catgttattg gcttgttctt agctggagga atctcaggct tttggcaaaa tattcaattt
     4501 ttagctgaag aacatcctga gattgaaatg gcatttccag acagtaagat cacatctgct
     4561 cctttaggta gtatggtaaa aaatgtgcta gattggtcac gtcaaggaat gacatttcaa
     4621 gctattttaa acaagctgca agaacagatt gatgggacga cagcctttat tatggttgat
     4681 gaccttaatc atctggttaa aggcggacgc ctgtcaaatg ggtctgctct tcttggaaat
     4741 cttttgagta ttaaacctat cttacgcttt gatgaagagg gaaaaatcgt tgtttatgaa
     4801 aaagtgagaa cagaaaagaa agccatgaaa cgcttggttg agattttaaa tgacttgata
     4861 gcagacggtc agtataatgt gtctattatt cactcaaaag cacaagacaa agctgattat
     4921 ttgaaacgac tcttacaaga cagtggttat caatatgaca ttgaagaggt tcattttgga
     4981 gcggtgattg ctactcattt aggagaagga gccattgcat ttggcgtaac accgaggctt
     5041 taattgtcga ttagaaaaaa tagttaattg caagaatcac taaaacaata acaaaatgtg
     5101 atagaaccca agtagcctaa tcacacttta gattgggcta gttggatgat aggttagaaa
     5161 acaacgtatg aaattaatga caatgccttc tgagtttcag aaggctttac ccatattgac
     5221 taaaataaaa gaagctggtt atgaagccta ctttgtggga ggaagcgtca gagatgtttt
     5281 actcgagcgt cccattcatg atgtagatat tgcaactagt tcctatcctg aagagactaa
     5341 agcgattttt aacagaactg tcgatgttgg cattgaacat ggtacagtgc tcgtgcttga
     5401 aaatggcggt gagtatgaaa tcacaacctt taggacagaa gatgtctatg ttgactatcg
     5461 ccgtcctagt caggtttctt ttgtgcgctc tttagaagaa gacctcaaac gtagagattt
     5521 cactgtgaat gccttggcct tggatgaaaa tggtcaagtt attgataaat ttagaggact
     5581 cattgatttg gagcaaaaac ggttacgagc agtgggtaaa gcagaggaac gttttgaaga
     5641 agatgcacta cgcattatga gaggctttcg atttgcggcg agtctggatt ttgacattga
     5701 agctgcaact tttgaagcta tgaggagcca ttcacctcta ttggaaaaga tttctgtgga
     5761 acgttctttt actgaatttg ataaattatt gatggcaccg cactggcgaa aagggatttc
     5821 tgccatgatt gcttgtcagg cttatgacta tttaccaggc ttgaagcagc aggaagcagg
     5881 cttgaatcat ctgatagttt ctttgaaaga taactttacc tttagtgatc accaccaagc
     5941 ttgggcttat gtgatgatta gtttagccat tgaggatcct aaaagcttcc taaaagcatg
     6001 gaagacttca aatgattttc agcgttatgt cacaaagttg attgctcttt atagaattcg
     6061 tcaggaaaga tcttttgaaa aattggatat ttaccagtac ggcaaggaaa tggcaagtct
     6121 agtggaaggc ctccgaaaag ctcaaagctt atctgttgac atggaccaca ttgaagcttt
     6181 agatcaagcg ctagccattc ataacaaata cgatatcgtc cttaatggtt ctcacctgat
     6241 taaggatttt gggatggaac caggtcctca gctagggctt atgcttgaga aagttgaatt
     6301 agcgattgta gagggacgcc tagataatga tttcactaca attgaagcat ttgttagaga
     6361 ggaattagca acatgagcca ttttttggtg gagaaattga caaaaacggt gggagataag
     6421 accgtctttc aagatatttc ctttattatt catgactttg accgtattgg gcttattggg
     6481 gttaatggaa caggaaaaac aactctttta gatgtcttgt cgggaaggct tggttttgac
     6541 ggagaccatt caccattttc taaagccaat gattacaaaa tcgcttactt aacacaagat
     6601 cctgaattta acgatgcagc ttctgtttta gatacggtat tgtcatctga tgttaaggcg
     6661 attcaactga ttcgtcaata tgaactattg atggcggatt atactgaaga taaacaagag
     6721 accttagagt ccctcatgtc tgaaatggat cgcttagatg cttggtctat tgaaagtgat
     6781 gtcaaaacag tcctatcaaa attaggcatc acggatttgg aacaaaaagt gggagaccta
     6841 tcaggtggta tgagaagacg tgtccagtta gctcaagtat tgctaggagc tgctgactta
     6901 ctcttgttgg atgagccgac caaccatctc gatattgaca ccatcgcttg gttaacaacc
     6961 tatctcaaga cagctaaaaa aaccgtcctt tttattaccc atgaccgtta tttccttgat
     7021 catgtggcta cccgtatttt tgaattggat aaagcgggac tgacagaata tcaaggcaat
     7081 taccaagact atgtgcgctt aaaagcagaa caagacgaac gagatgctgc taatttacac
     7141 aagaagaagc aactctataa acaagaatta gcttggatga ggacgcagcc acaggcgcgt
     7201 gcaaccaaac agcaggctag aatcaatcgt ttcactgact tgaaaaaaga agttcaccaa
     7261 gacagttctg cagataaatt ggagatggct ttcgaaacga gccgaattgg gaagaaggtg
     7321 attcactttg aagacctttc ttttgcttat ggcgaccgac agttgattaa ggattttaac
     7381 ttgattattc aaaataaaga tcgtattgga attgttggag ataacggcgt cggaaaatct
     7441 accctgttga atttaattaa tggagatctt gaaccaactt ctgggaagct tgatattgga
     7501 gatactattc gtgtaggtta tttctctcag cagctcaaag atatggatga gaccaaacgg
     7561 gtcattaatt accttcaaga agtggctgat gaggttaaaa caagtgtggg aacaacgagt
     7621 atcagtgagc ttttagaaca atttcttttt ccgagatcaa gtcatggcac gctgattgct
     7681 aaattatctg gtggggagaa aaaacggctc tacttgctaa aactgctcat tgaaaagcca
     7741 aatgttcttc tccttgatga gccaacaaat gatttagaca ttgccacctt gacggtctta
     7801 gaaaactttt tagctaactt tgcaggacca gtcattacgg ttagtcacga tcgttatttc
     7861 ctagacaaag tagctactaa gattttagcc tttgaagaag gcgatattcg tgttttttat
     7921 ggcaattaca gtgattacct tgatgaaaaa gtttttgaaa aagaaacagt tgaggctgac
     7981 ttggttaaaa caacagtcac tgaagaagtg ccacttcctc aaaaagagga aagaaagcgc
     8041 atgtcctacc ttgaaaaaca agaatgggct cagatagaag ataaaatagc aactattgag
     8101 gctaatattg aagaaattga aaaccaaatg ttaactgtag ttagcgatta tgaccagtta
     8161 gctcaattac aaaaggaact cgatcagcac aataatgatt tattattggc gtatgaacgg
     8221 tttgagtatt tgagtggact agacatataa gaatactatg gtaatgttat gtttataata
     8281 aacaagtgat aatagaaaag aagtgctctt gcactgagcc ccaaaagttg gctactctat
     8341 ttgaagtaaa ggatttagtt ctgtgttgta gaggactaag tccttttcgt tttattttga
     8401 tacgtttatt gttgcaataa tcgatgataa tagtaggtag aacgagtcac tttagccgtt
     8461 cttaaaagaa aatctaatca gaactcgtct ttgtccattc tttataatgg ttttttgtct
     8521 tcttctttgc agagatgctt ctttcaaacg gagttccctc ggttttttta gcgctaaata
     8581 tctagcttat cttcatagct taatgtcata caaaaacacc ccaaacgtta gattttttta
     8641 tctaacgttt ggggtgtagt ttacattatg gcgcttcttt tctattatta cgtgaggaaa
     8701 aatcaagtaa aaaagttaag tcaactgaaa aacttgacag aaatattcag aaaatttata
     8761 atactaacta ttaacaacat atcagctatt aaagtatttc aaacagcagg tgttttattt
     8821 ggacctgtta aggttgcaaa tgcaagagaa agcagtatct ggtttgaaaa tctcacaaag
     8881 caataactat ctctcttaga catttgaaga agcagatagt aaattcgata atattgtgat
     8941 gagaacttag caacaatctg ctgatgcagg tcaattttta tttggtactc atattgcaga
     9001 atttcataaa gttgcccaag atatcttgaa ataaggaatc acctgatgtt ttaaacagat
     9061 gatactaagt ctatcatatg gtgataatag tccattgaac atgtagttta tgaattaaaa
     9121 agaaggttta aggagataag aatgattaga gaaatcataa cagatcattt tttattacag
     9181 caaaaagcgc aagtcgccaa gaaagaagat ctatggattg gccaagattt acaagatacc
     9241 ttagcctttt atagacagga atgtcttggg atggctgcca atatgattgg tgaacaaaag
     9301 cgcattgtta ttgtgagtat gggatttatt gatttggtta tgtttaatcc tgtgatggtt
     9361 tctaaaaagg gaatttacca aactaaagaa tcttgtttgt cgttatctgg ctatcgcaaa
     9421 acacagcggt atgataagat tactgttgag tatttggacc ataattggcg accaaagcga
     9481 ttaagcttaa caggcttaac tgctcaaata tgccagcacg aattagatca tctagaaggt
     9541 attttaattt aacaaaaaac ctagagtagg acgctttagg tttttttggc aaagatgcct
     9601 gattatataa gggtgatcga ttactagtaa acgctaggat ttcctttttt taataaaagc
     9661 gtttagtcca cctaagctta tcaaggcaag gattgtcata ataggagaca ttttataatt
     9721 gtcccctgtt attggaagag tggaactaga gatagtattt ttgtttgtcg ttgtttcttt
     9781 tttgccaagg ctgttattag tgttttcagt agaagtcaaa aggtctgaaa tgacttcact
     9841 agacactata ttgccatcac gatttctaaa aaccttacta atgatactgt gtttaccagc
     9901 actattaact tttgtcgaac tttcaaggtt tgaagttaca taatttttaa ccccttttat
     9961 agtagcatta acagttttac ctgatgcttc taaatttgtg atatatgtga tgaaagcttc
    10021 agtatctgtg ttaatagctc cgattaattt agctttttta aatgctgaaa agccatcacc
    10081 accaccataa agaaagtcgt tgacaacaac ggtgtaagta gttgttaagt taatttcttc
    10141 accattgtct ttataaacct taactatctt gaagggggta tcagagttct taggatcatt
    10201 atctgtataa gtgtatgtta aacctgacat ttgaagaaaa taggtctggt tttcatcgta
    10261 ttgctgattt aggacatcgt aaatgtgttg accagtcatt tgaatgactt gaaggatatt
    10321 accaaatggt tgtacagcct gtgcagctcc ccaggtgatg gtccggtcat ttttgacaac
    10381 taggtcactt cgaataccac cattattggt catagcaaag tcaacagttg gaaaagtttt
    10441 cttagcaata gtaagctgag ccgttgttac taagttaccg acaggagatt ctttatcaat
    10501 attttctgtt ttagaaatag ttgaagaatt agttgcagtt ccgatttttc gttcagtaac
    10561 tgttttaaca atatcattag catgatttat tatagctttg atatctgaat tttctgtttt
    10621 gatacctggt gctacagcaa caacatttgc tgatggagtt gtcataaaat cattggtatc
    10681 agtatctagc gttccacgga catctgcata agcttttcct tgagagaggg cttgaacgat
    10741 acgtgtttta ccgatagttc cattagtgta ttgatgatta tgtcctgcaa aaataatatc
    10801 aatgctatgt tcgggataga tttggttcac tttttccata accgtagcca tttcatgatc
    10861 aacaacacca tctttacttg ttgcaggaac atgagctaaa accacaatag catgaacatg
    10921 ttgttcttgt agttctttag catatttggc aatggtttca gctacatcta aaaattgata
    10981 gtgttcatag ttttgcttta aaacgagatt tggaatctct gtagtcacaa caccaatgaa
    11041 gccaatctta acgattttgt cattaatggc tatgtctttt atagcataag gtttccaacc
    11101 ataggggata tcattggttt ttttatcaat gacattagca atgacgatgg tttgatgcga
    11161 agcttcgtgc tcatattgtt tggtgatatc attaattgtt gattcaggat caggcgcttg
    11221 acctgtcatg atacggttaa attcatctag tccttcgtca aattcatgat taccaagagt
    11281 gccatattca aatttcattt tgttaaagac tttcacagta ggctcatctt gtaaaagtgc
    11341 agagttagca ggactggctc cgaccatatc tccagcttga acacgtatac ttgttccgtc
    11401 ttgatttgct tgcttgaaat ctatctcagc gtcatccata taagcaccta attgagcagc
    11461 cgtcccagca tttggtattt taccacttgg tgtgtaagct gttccggtat tatcaagagc
    11521 gccgtgaaaa tcattgacgc caaggaattg cacatcaact tgatctgctt gaacgtctgt
    11581 aactaataga gtaaaactag tcaggatact caatacacta ctttttaaaa taaaatattt
    11641 tttcataaaa tctcctaata agttaacgta atcgttatag atcaagttta ctatgttttt
    11701 gtttgtaatt caatggtatt ttaaaaaaat aacgtacaaa aaatatatga aagcgattta
    11761 aaaacaaacg ataaagatca tttacagtta tatagttaga aataaagata accgatcatt
    11821 gtagagattt aagcatttgt tgagaaaatt tgttataata agcgtatgaa agaaagacta
    11881 gaacattatt ctaccagctc tatatatagc ggatttgaag tgtacttgcc gttagtacta
    11941 cagacaataa cagatgtgat tattgctgag aatatcaaaa gcaaaaaaga aacagggttt
    12001 aaactatatg aacactttac atcccgtatt aaatcggaag cttcgatgat tgaaaaatgt
    12061 caacgcaaac agcttcctct aacaagcaaa tctgcgttaa aaatcattaa agatagtatc
    12121 ggtattcgca ttatttgtgg ttttattgat gatatttatc ggatggtaga cttgctcaaa
    12181 agcattcctg gtatgtcagt taacactgaa aaagattata ttttaaatgc caagcctaat
    12241 ggctatagat catatcatct cattttggaa ttagaaacac attttccaga tattttaggg
    12301 gaaaaaaaag gatgttattt tatagaagtg cagttgcgaa ccattgctca agactcttgg
    12361 gctagcttgg aacatcaaat gaagtacaaa catcaagttg ctaatgcaga aatgattaca
    12421 agagagttaa agcgttgtgc agacgagttg gcatcttgtg atgttaccat gcaaaccatt
    12481 cgtcaattga ttcaagaaac gacggaggaa gagtaaccat gaaaattttg ttagctgaag
    12541 acgaatggca gatgtctaat gttttgacaa ctgccatgac tcatcaaggt tatgacgttg
    12601 atgtggtttt taacggtcaa gaggcaattg ataaagccaa agacaatgca tatgatatta
    12661 tgattttaga tatcatgatg ccgattaagt ctggcattga ggctttaaag gagattcgcg
    12721 cttcaggaaa ttgctcacat attattatgc tgacggctat ggcagaaatt aatgaccgtg
    12781 ttaccggact agatgcggga gctgatgatt atctgactaa acctttctca ttaaaagaac
    12841 ttttagctag attaaggtcg atggaaagac gagtagaaag ttttactcct caggtattac
    12901 aatttgctgg tgtcacatta aatattaatg agcaagaatt gagtgccggt aatgctatac
    12961 gattagcttc taaagaaggt aaattaatgg cctttttaat gttaaatcaa ggaaagtact
    13021 tggatactaa aacgctttac caacatgttt ggtcagacca agaagattat gatacttcta
    13081 ttgtttgggt ttatatttct tatcttcgtc aaaaattatt agctattcaa gcaaatgtca
    13141 ttattgcagg tgataaagat actagctatt gtttattaga aaaataggag gtgacatgtt
    13201 taatcgtatc cgtattcgtt ttatcatgat tgcttctatt gccattttta ttattttaag
    13261 ttcaattgtt ggtattatta acacggcacg ctgttaccaa agtcaacaag aaattaaccg
    13321 tattttacat ttaatttcct caaataaagg taaattacct ggcactacgg aaagctctaa
    13381 acgacttgga acgaaactgt ctgaagatag cctaagccag tttcggtatt atagtgtcat
    13441 ttttaatgct aatggacatc tactttcttc taatactgct aatatttcag ctttagatag
    13501 agaagaagcc caatattttg ctagactttt tgctaagtct ggggaagaaa aaggcagtta
    13561 ccgtcaccaa gatagtgttt attcgtactt gattactcag ctgccaaatg aagaaaaact
    13621 ggttgtaatt ttagatacta ccttttattt tcgtagtgta ggagatttat tagctgtttc
    13681 agtgatgttg gcctttggag gatttatctt ttttgttgtt ttagtgagtc ttttttccgg
    13741 tatggtcatc aaaccttttg tccaaaatta tgagaagcag cgtcgcttta ttactaatgc
    13801 aggccacgag ttaaaaacac cactagccat tatctcagcc aataatgaat tggtcgaatt
    13861 aatgactgga gaatcagaat ggaccaagag tacaagtgat caggtgaagc gattgacagg
    13921 cttgattaat caaatgatta ctttggctcg tttggaggaa cagccagatg tggtattaca
    13981 tatggtagat ttttcagcta ttgctcaaga tgcagctgaa gattttaaga gtctggtttt
    14041 gaaagatggt aaacgttttg atttgacgat tcagccgaat attatgatta aagcggagga
    14101 aaagtcattg tttgaacttg tgacaatttt agttgataat gccaataaat attgtgatcc
    14161 taaaggcttg gtcaaggtat ctttaaccac tattggaaga agacgaaaac gagcgaaatt
    14221 agaagtttct aatacctatt tggaaggaaa atccattgat tacagccgct tttttgaacg
    14281 cttttatcgc gaagacgaat cccataatag caaagaaaaa ggttatggaa ttggtttatc
    14341 tatggcagaa agtatggtta agttatttaa aggaacgata actgtaaatt ataaaaacga
    14401 tgctattgtt tttacagtgg tgatttgact taaacatttt tcagtacctt tagctagtaa
    14461 taatgtctag gtaaaggtaa taaacgatgc ttaaccagcc catgaggctg gttttaacgt
    14521 ttaatttagt agaagagtga ttaaagaagg tagtttgaaa taagaaaatt tttgttatga
    14581 tcctaaaaag agtagatagt ctttattgtt aatttcagtg aagaaatgat tttaaaaaga
    14641 tatatcatcg cattttctaa tcatttagtg taaaatagta aggtaaaagt ttagaagaat
    14701 tagtaatgaa aagataaaaa atgaatgaaa acattggata tggtaaggca cacagtaaga
    14761 tcattttgat aggtgagcat gctgttgtgt atggctaccc agctattgct ttgcctttaa
    14821 cagatattga ggtggtttgt catatttttc cagctgataa gccattggtc tttgattttt
    14881 atgatactct atcaacagcc atttatgctg ccttggatta tttgcagcga ctacaagaac
    14941 caattgctta tgagattgtt tcacaagtgc cacaaaagcg tggtatgggg tcttcggcag
    15001 ccgtttctat tgcagctatt agagccgttt tttcttattg tcaagaaccc ctctcggatg
    15061 atttgttgga aattttagtc aacaaggcag aaattattgc ccacaccaat cctagtggtt
    15121 tagatgccaa gacatgcctt agtgaccatg ccattaagtt tatccgaaac attggctttg
    15181 aaactatcga aatcgcctta aatggttatc ttgtcattgc agatacaggg attcacggtc
    15241 atacacgtga ggccgtcaat aaggtagcac agtttgagga aacgaatttg ccctatctgg
    15301 ctaaactagg agctttgaca caagcccttg aaagagcgat taaccaaaaa aataaggtgg
    15361 ctatcggtca gctcatgaca caagcgcact ctgctttaaa ggccattggc gttagcatca
    15421 gtaaagctga ccaacttgtg gaggctgccc taagagcagg tgctttaggc gctaagatga
    15481 caggcggtgg cttgggtggc tgtatgattg ccctagcaga taccaaagac atggccgaaa
    15541 aaatcagtca cagattaaaa gaagaaggag ccgtaaacac gtggatccaa atgttataac
    15601 cgtaacatcc tatgctaaca ttgctattat caaatattgg ggaaaagaga atcaagctaa
    15661 gatgattcct tcgacctcta gcatttcttt gactttggaa aacatgttca ccacaaccag
    15721 cgtttccttc ttaccagata ctgcaaccag tgatcagttt tacattaacg gtgtcttgca
    15781 aaatgacgaa gaacatacca aaatttctgc tatcattgac caatttcgcc aacctggtca
    15841 ggcttttgta aagatggaaa ctcaaaataa tatgccaaca gctgcaggtt tatcatcaag
    15901 ttccagtggc ttatcagcct tggttaaagc ctgtgatcaa ttatttgaca cccagctaga
    15961 tcagaaagct ttagctcaaa aggctaagtt cgcctcagga tcatcttctc gttctttttt
    16021 tggcccagtc gctgcttggg acaaagatag tggtgctatt tacaaggttg agactgactt
    16081 gaaaatggcc atgattatgc tggtcttaaa tgctgcgaaa aagccaattt ctagccgaga
    16141 gggcatgaag ttatgccgcg atacctcaac tacatttgat caatgggtag aacaatcggc
    16201 aatcgattac caacatatgc ttacctatct caaaactaat aattttgaga aagttggtca
    16261 gttaacagaa gctaatgcct tggccatgca tgccacgaca aagacagcca atcctccctt
    16321 ttcttaccta acaaaagagt cttaccaggc tatggaggct gtgaaagaac tgcgtcaaga
    16381 aggttttgct tgttatttta ccatggacgc aggtccaaat gtgaaggtcc tatgtttaga
    16441 aaaagacttg gctcaactag cagaacgact tggcaagaac taccgtatta tcgtttcaaa
    16501 aacaaaggat ttaccagatg tctaattatt gtgtgcaaac aggtgggaaa ctatacctca
    16561 caggcgaata tgctatctta acaccaggac aaaaagcctt aattcacttt attccactga
    16621 tgatgacagc agaaattagc ccagcagccc atattcaatt agcttcagat atgtttgccc
    16681 ataaagcggg catgacaccc gatgcctctt atgcactgat tcaagcaacg gttaaaacct
    16741 ttgctgatta tctaggacag tcaattgacc aactggagcc attttcccta attgtaacgg
    16801 gaaaaatgga gcgcgatggc aaaaaatttg gcattggttc aagtggtagt gtcaccctct
    16861 taaccttaaa ggccttatcg gcctattatc agatcacttt aaccccagag ttactcttta
    16921 aactagcggc ttataccttg cttaagcaag gagataatgg gtctatgggg gatattgcct
    16981 gtatcgctta ccagacttta gtcgcctata cctcctttga ccgagaacag gtcagtaact
    17041 ggctgcagac catgccctta aaaaaacttc tcgtcaaaga ttggggttac catatccaag
    17101 tcattcaacc agccctgcct tgtgactttt tggttggctg gactaaaata cctgctattt
    17161 caaggcagat gattcaacaa gtgacagcga gcattacccc agctttctta agaacaagtt
    17221 accagctaac gcaatcagct atggtagctt tgcaagaagg tcataaggaa gaactcaaga
    17281 aaagtttagc aggagcaagt catctcctaa aagagcttca tccagctatc taccatccta
    17341 agctagtaac cttggtagct gcttgtcaga agcaggatgc tgttgctaaa tcttcaggtt
    17401 ctggtggtgg agattgtggc atcgcgcttg cctttaatca gaatgccaga gatatcctta
    17461 tttccaaatg gcaagaagct gatatcgcat tactttatca agaaaggtgg ggagagaatg
    17521 accaaccgta aagatgatca catcaaatat gccctcaagt accaatcgcc ttataatgct
    17581 tttgatgaca tagaactcat acatcattcc ttacctagct atgatttgtc tgatattgat
    17641 ctcagtactc attttgccgg gcaagacttc gactttccct tttacatcaa tgccatgaca
    17701 ggaggaagtc aaaaaggcaa agctgtcaat gaaaaattgg ccaaagtagc agcagcaaca
    17761 gggattgtca tggtgacagg gtcttatagc gctgctttaa aaaatcctaa cgacgattcc
    17821 tatcgtttac atgaggtggc agataacttg aaactagcca cgaatattgg tctagataaa
    17881 cctgtggcgc taggacaaca aacggttcaa gaaatgcagc ccctcttttt acaggttcat
    17941 gtgaatgtga tgcaagagtt gctgatgcca gagggtgagc gcgtctttca tacctggaaa
    18001 aaacacctcg ctgaatacgc tagtcaaata ccagttcctg tcattctcaa agaagttggt
    18061 tttggcatgg atgtcaatag tatcaagcta gcacatgacc taggcattca aacctttgat
    18121 atttcaggaa gaggagggac ctcatttgcc tatattgaaa atcaaagagg aggagaccgc
    18181 tcttacttaa acgattgggg acaaaccacc gttcagtgct tgctaaatgc acaaggactg
    18241 atggaccaag tggaaatctt agcttcgggt ggtgtcagac accccttgga catgattaaa
    18301 tgtttcgtcc taggagcacg tgcagtggga ctctcacgca ccgttttaga attggtcgaa
    18361 aaatacccaa ccgagcgtgt gattgctatc gttaacggct ggaaagaaga attaaaaatc
    18421 attatgtgtg ctcttgactg taaaactatt aaagaattaa agggagtcga ctacttacta
    18481 tatggacgct tgcagcaggt caattaggct tcatcacctc tacaatagtg ccacctacta
    18541 caaagatgat agagcttttt tagaacataa tataaaatat ttataaatac ctcatcaaac
    18601 tcagaataga gtagatgagt aaatagagta tgttatggag actatttcta agacttgtat
    18661 gtatagaaac aaagattaaa cacccatgta aaccaattgt ttacatgggt gtttgcctta
    18721 tattagttgt ttaaatctaa gactgtctta gctgggataa gtaaaaatgt gctttttcta
    18781 gatttattgg tttatcagct agtaaagcat taactaaagg agcaatttcg tcttgggttg
    18841 cccccgccaa aagagctaat gatttcgcat gtagtttcat gtgaccagct tggatgccag
    18901 atgaggtcag agcttttagt gcagcaaagt tttgagctaa ccccacagat gcaatcaatt
    18961 gggctaatgt tttggcatca ggttgattaa gaagatcatg tgcgatagaa acagtagggt
    19021 taagcccgat agatcccccc ttactagcaa taggcatagg gagggtcatt tggccaagca
    19081 gaacttgttt atcttggtca aaatgccact gactaagtcc ttgatagcta ccatttcttg
    19141 aggcataagc atgggcccct gcttcaatag cacgccagtc atttcctgtg gctattacca
    19201 ctgcatcaat gccattaaaa atacctttat tatgagtagt agcccggtaa ggatctactt
    19261 gagctagtcg gctggctagc tctatttttt gagctaactg tagggatttt gttttatcgc
    19321 gatctaaaag gcgcacggga atctcacaac tagtagtaac aagcgactct gttgcgtaat
    19381 tagataaaat cgccattaga caatgcccct tagacagtct tgttaaatca ggaacaagag
    19441 cttccatcat agtattgacc atatttgctc ccatagcttc ttgggtatca acagtcagat
    19501 agaaaatcaa aaactctcct ttttcttcca aatgaatggt tctagcgcct ccacctcttt
    19561 taacaatgga aggataagct ttatttgcca atgcaattag cttttttgtt ttatgaagga
    19621 tggcggcttt agcgttatct atttggtcga tatcgtaaag aacaatttga ccaatcattt
    19681 gtcggtttag ggtttgagct ttaaaaccac ctgagcgttt gattagtttt gctgcgaaag
    19741 atgctgcagc aacaacagaa ggttcttccg tgacaaaagg catctgataa gttgaaccgt
    19801 tgacaagaaa atcaggagct atgctaaagg gcaaagccaa tcgtcctaag acattttcag
    19861 tcatttgatt agctgtttgg ataggcaaaa gaacgtctgt tttgagttga tttaagtttt
    19921 cagcattaag tagtttaaat ttttcgataa gttggaggcg ttcttcgaat gttttctttg
    19981 aaaaaccgct ccagttaaga ttagtttttg tcattggtac gatagatcct ttgatgctcc
    20041 ttgatggctg ttagagcaaa ttttccagtt aagtaaatgt caaaattggc attaccatta
    20101 tcatctaatt ggacttgttc gtagaaaagg tcttcgtatt tagaaacgga aagacgtgtt
    20161 cgttgatcca gtaaagcttg tcgattagtc attaacattt tatcgtaccc agcaactaac
    20221 tgagcggaat aaaattcact tacggcaccg gaaccatagc taaaaaaacc aattttatct
    20281 ccagattgta atactttact attttcaagt aaagataaca atcctagata aagtgagcca
    20341 gtataaatat ttccaatttg tttgctataa gtaatagaag cttgaaaggc ttctattagt
    20401 ttttccctgt gttcaggagg tactgtgtta tccataatgt tatttagacc ttttagggct
    20461 aacttgggaa atggaatatg gaaacaaact gcagcaaaat cagataactg aaggttttct
    20521 cttttctgat aagcttgcca cgtggtttct aagcaattga gatattgctt ggtagagtaa
    20581 ataccatcaa cataaggtgt gaaactatag ttaggcctcc aaaagtccat aatatcccta
    20641 gtttgagcca cattatcttc atttagagca agaatacgag ggtcagcagt taccaaaaga
    20701 gcaatactac cagatccttg agttgattcg ccaggagatc ctacaccgta tctagcaata
    20761 tcactagcaa taacaaggac acgagaatct ggcttagaag ccacatgcag tttagcatag
    20821 tctagagcag cagttgcgct atagcaggct tgttttactt caaaggaacg tgcaaaaggc
    20881 tggataccaa ctaagtgatg tacatagata gctgatgcct ttgactgatc agtactcgat
    20941 tcagttgcca aaataaccat atcaatctta gctcgatctt cgtcggttaa gatttgatct
    21001 gctgcagaag cagctaaagt aataatgtct tcagtgattg gtgccacact aaaagattca
    21061 atgagtagcc cttgactaaa ttttgctgga tccacttggc gtgcaagcgc taaatcttcc
    21121 aatttcaaga catattgact ggttgcaaaa ccaatcttat caattccaat tgtcatattt
    21181 gtccttcttt tagttatttt tatagtctta cccattctat cacattttac tgcaaaatta
    21241 gactgataaa gttatttgtt ttatccttta atagttaaaa tattcatgac cacatgaagt
    21301 ttttcgaatg tttatttatt ctggtatttt ttggtaaaat tagttagaat agtatgaagt
    21361 atgcttacag aaaggttatt agagatgaca aaagctgacc agatttttaa agctaatatt
    21421 caaaaaatta taaacgaagg atcattgagt gagcaagcac gtcctaaata taaagatggc
    21481 cgaacagctc attctaagta tattactggg gcgtttgctg aatatgattt agctaaagga
    21541 gagtttccca tcacaacttt acgacccatt ccaattaaat ctgctataaa ggaattattt
    21601 tggatatatc aagatcagtc taacagttta gatgtgctag aagctaaata taatgttcat
    21661 tattggaacg aatgggaagt tgaccagaca cgtactattg gacaacgtta tggtgctgta
    21721 gtcaaaaaac atgatatcat ctcaaaaata ctaaagcaat tagcagaaaa tccttggaat
    21781 cgtcgtaatg tcatttctct ctgggactat gaagcatttg aggagacaaa agggttgttg
    21841 ccatgtgcct ttcaaatcat gtttgatgtt agacgtgtag gggaagatct ttatttagat
    21901 gctagtttga cgcaacgttc taatgacata ttagttgctc atcacatcaa tgccatgcaa
    21961 tacgttgcct tgcagatgat gtttgctaaa catttcggat ggaaaatagg taagttcttt
    22021 tattttgtta acaatttaca tatttatgac aaccaatttg atcaggctca agaattacta
    22081 aaacgacagc cagttgccag tcagcctaag cttgttttaa atgttccaga tgggactaat
    22141 ttctttgata ttaaaccaga tgattttgaa ttacaaaatt atgatccagt gaagcctcag
    22201 ttgcactttg accttgctat ttaaacttta tttagatttt ttgtgagcat tttgttcata
    22261 aatttggtaa aataaataga gtttaaaatg aaggaaataa ttaatgacaa aggaaattat
    22321 tgctatttgg gcagaggatg aagcagggct tattggtgtt gcgggtaagt taccatggta
    22381 tttaccaaaa gagttagaac attttaaaaa gacaacgcta catcaagcaa tcttaatggg
    22441 ccgtatgact tttgaaggaa tgaattgcaa aagacttcct caacgtcaaa cccttgtcat
    22501 gacaagaaat agagattatc aagtagatga ggtgttgaca atgactagta ttgaaaaagt
    22561 cttggagtgg taccatgcgc aggataaaac actttatatc attggtggga ataaggtttt
    22621 agaagcgttt aatggttatt ttgatcgtat cataaaaaca gttatccatc atcgttttaa
    22681 aggagatacc taccgaccca atctagattt tagtcatttc acgcaagaaa gccaaacgtt
    22741 ctatgctcga gacgctaaaa atccttatga ttttaccgtt actgctttaa aacacaaata
    22801 gtctgaggag atgataagcg atgcaacgta gtatttttgg agtatttacg gcttttttgt
    22861 gcgtgatttg tgttctttgt gccatcccag cttttaaaaa gaatcgttat ggcttaggaa
    22921 gtctgttctt attaaatgcg tttactaatc tggttaatag tattcacgcc ttctatggta
    22981 cattgttttg agatgcgact tgcaaagaca gcactggtga agatttagct atcaagcaag
    23041 aatcaccaaa aaccaataca acacattgac taatattaaa attcagtaaa agataagaga
    23101 aagtaagaga attataagaa atggcaggaa gtagaactaa cgatattaaa gtatactgtt
    23161 cattttgtgg taaaagccag gatgacgtta aaaaaattat cgcaggaaat aatgttttca
    23221 tctgcaatga atgcgtagct ttatcacaag aaattataaa agaagaattg gctgaagaag
    23281 tccttgccga tttgacagaa gttccaaaac caaaagagct ccttgatgtt ttaaatcaat
    23341 atgtggttgg tcaagatcgt gctaaacgtg ctttatcagt tgctgtgtac aatcattata
    23401 agcgtgtctc gtttacagaa agtcgtgatg acgatgatgt ggatttacaa aagtccaaca
    23461 ttttgatgat tggaccaaca ggttcaggaa aaaccttctt agcacaaact ctggctaaaa
    23521 gcctcaatgt accatttgct attgcagatg caacttcttt gactgaagca gggtatgttg
    23581 gagaagatgt ggaaaatatt ttactcaaac tgattcaggc tgctgactat aatgtcgaac
    23641 gagcagagcg tggtattatt tatgttgatg aaatagataa gattgctaaa aaaggtgaga
    23701 acgtatctat cacacgtgat gtatctggtg aaggtgtaca gcaagccctt cttaaaatta
    23761 ttgaaggtac ggtagcaagt gttcccccac aaggtgggcg gaagcaccct aatcaagaaa
    23821 tgatccaaat tgatacaaaa aatatcttgt ttattgttgg cggggctttt gatggcatcg
    23881 aggagattgt taaacaacgt ttaggtgaaa aagttattgg ttttggtcaa aacagccgta
    23941 aaattgatga caatgcttct tatatgcaag aaattatttc agaagatatt caaaagtttg
    24001 ggcttattcc agaatttatt ggccgcttac cagttgtggc agcccttgaa caactaaaca
    24061 catcagattt gattcaaatt ttgacagaac caagaaatgc cctggtcaag caatatcagg
    24121 cccttctttc ttacgatggc gtcgaattgg catttgataa ggaagcctta gaagccattg
    24181 ccaataaagc cattgaacgt aagacaggag cacgtggtct tcgttctatt attgaagaaa
    24241 caatgcttga cattatgttt gaaattccaa gccaagaaga tgtcacaaaa gtgcgtatca
    24301 ccaaggctgc tgtcgaaggc aagtcaaaac ccgttttaga gacagcttaa ggagaaataa
    24361 tggctgaaga acaagtctta aatacccata acgcctcaat tttattgagt gctgccaata
    24421 aatctcatta cccccaagat gatttgccag aaattgccct tgctggacgt tcaaatgttg
    24481 gtaaatcaag ttttattaat accatattgg ggcgcaaaaa tttggcaaga acctcaagca
    24541 agccaggaaa aacccaacta ttaaattttt tcaatattga taacaagctt agatttgtgg
    24601 atgtccctgg ttatggctat gccaaggttt ctaaaagtga acgggccaaa tggggaaaga
    24661 tgatcgaaga atacttaacc agcagagaca atctgcgtgc agtcgtgagt ttggttgatt
    24721 tacgtcatgc cccttcaaaa gaagatattc agatgtatga ctttttgaag tactatgaca
    24781 ttcctgttat tgttgtggca accaaagcag ataagattcc tcgtggcaaa tggaacaaac
    24841 atgagtctgt ggtcaagaaa gctttgaatt ttgacaaatc tgatactttt atagtatttt
    24901 cttcggtaga acgtattggt atcgatgatt cttgggatgc tattttagag caggtctagc
    24961 gataggtgtt gatttatcta tgctaaaaca ttctcagtag agggtgtttt tcttatcgaa
    25021 aacataaaaa atcatagtta ggtttaccga ttttacttga cgccttaatg atgacatgct
    25081 agtattttat attaaggaga tgagtcatga cacaagtagc ccaagggcgc tctaaaggaa
    25141 agtcattgtt atgccatcaa tgcaatgccc tttttgtatt tattattttt cttatcttgc
    25201 ttgctgtact ttttggtgtt cgatatcgta atagctctat tgaaggtatc tggcgaacaa
    25261 caagcattga tcagaagtta ggcgatgatt ttgctaaacg tcttactggt ttgcatcaga
    25321 gccctcttat tgatgatagt ttattaacgt catctcagat gatactaaca gttaaaaata
    25381 acaacgttga cttgagtttt agtgttcaag ttgaacgaga catttttgtc aaacgtttag
    25441 ctgcttatca ccaaaatgaa ttattaaaga cattaaagga aaatcattta gttgttggtg
    25501 acttgagtag taaagaacgc caaatcattg agaatagtat gccagctagc catgaattag
    25561 aaatgatttt agatcaagct tttgagaaat tagcttctca gatcggaggc aaatataatc
    25621 aaaaaacagg acatttatct gctgttgttc tcaaaggaaa agttaatcgt attttgcaca
    25681 ccattgatat caaagaagaa gtagcagcgg gacatacttc tttttcaaaa ggattgctca
    25741 cacctaatgg ttattttgat tacaccagat ttggaaagaa acttgagtta ttaggcgatg
    25801 aaaaaattat ttttaaaaaa gcgctaaaaa aaagtccgtc aagtgtataa cgtagtcaca
    25861 agacggattt tttcatgttt tgaaaattat tcaattgaag aagtttatta ctgatcgttt
    25921 tgcctaatca ctagttgtcc ttcttttagg attgcctgaa gttttttgac gtctggatgg
    25981 tcaagataat aatcagttat acggtcacga atttcctgtt cgataatacg tcgtaatgga
    26041 cgagctccca tagcgtgatt gtaccctaaa tctatcaaat gagctttagc gtcatcagca
    26101 atcgttaaac taataccttt ttttgcggtg gtttgattta cttcagctag cattaaatca
    26161 acaatttctt ctaaattttc tttttgcaga tgattaaatt taatgatact attaaaacgg
    26221 ttcaaaaact ctggtctgaa ataaggtgca atgcgatcca taatgttaga ctcagaagtt
    26281 tccgtatctt gttggccaaa accggcattt gatgtagcaa taataacggt atttttaaag
    26341 ttaatagtat ttccttgtcc atctgtcaat cgtccatcat ctaacacttg tagaagaagt
    26401 gtaatgattt gaggatcagc tttttcaatt tcatctagta agacaatagc ataagggtta
    26461 cgacgaacac gctcagttag ggtattatta ttatcatcgt agccaacata accagccgtt
    26521 gtcccaatca attttgacac agcagtgcga tcgttatatt cggacatatc aagtcgaata
    26581 atagcatctt tggaaccaaa taaatcaagt gctaattgtt tagctaactc tgttttacca
    26641 acaccagttg gacccacaaa aaggaaagaa cctattggac ggttaccatc atcaaaacct
    26701 gctcgatttc gtcgaatagc acgtgctact gctgcaacag cctcatcttg tccgatgaca
    26761 tggcttttta agcggctgct aattcctttg agcctttcta aatcattagt ccccatgtta
    26821 gagacgggaa taccagttaa gcgctctaca gactctgcga tatcattgac tgtagcagta
    26881 acattttggc tttggttatg ttgctcaatt tgcttttgta atgtttcaat ccgtgttttt
    26941 gctgctaaag ctttttcaaa gtcttctttg gcgacagctt tttcttgact ctctttttgt
    27001 ttagctattt cagtttcgag tgtttttaag tcagtgaccg ggtgttgcgc agctaaatga
    27061 gcagctgtca tatccagtaa gtcaattgct ttatctggca ggctacgctg tgggatgtat
    27121 tgaatagaat aatcaacagc agcttttaga acattatcag gaagggtaat atggtggtgt
    27181 tgttcataaa gattacgaat acacattaaa atgtgaaaag tatcttcagc tgatggtgca
    27241 ttcactttaa cttcattaaa gcgacgagca agagcagcat tttttaaaat agtattgcgg
    27301 tattcgtctt gagtagtagc accaatcagt gttaattctc ctcgtgacaa ggctggttta
    27361 agaatatctg caagtccctt tgagcctgaa tcactgcttg tggcaccagc accaactatt
    27421 tgatgaattt catcaaaaaa taagatgata ttcccagctt cttttacttc ttgaatcaag
    27481 ttttgaatgg tctcttcaaa ggaaccacga tactgtgtac cagcttcaag actagaaatg
    27541 tcaattgata cgatttcctt gtttttaata gcggctggga catctccatt aacaatggct
    27601 tgagctaaac cttcaatgac tgcagtttta ccgacaccag catctccgac aaggacagga
    27661 ttatttttag ttcgtcgtgc caagatttca gcggtatctt gaatttcttt gttacgacca
    27721 atgacggggt caagatgccc ttgacgagct tcttgtgtta agttagttcc gagttgagtc
    27781 aatacactat cagctttagg tgttaacatt tgagaatttg ttgctttggt tgtcgctaca
    27841 gggagttgtc ctgtttgacg atagtcttgg aattcttcgg gagttatttc gcgaccgtta
    27901 acgagatagc ggggattttc gctacgataa ccacccatgt ttgccattaa ttgattgaaa
    27961 atatcatcca tatttacaaa aggatcttta ccagaaaaat gtgtcatatc agttacctcg
    28021 caataaaaaa tagactataa gatgtttgta agcagtcgca gaatcgttgt taggatttca
    28081 catgatagga aatcctttgc taataaaatg attcagacat tatttttact catcttatag
    28141 tattattata atcaaaaggt cagtaaaggt caaacaaaaa acacttgatt ttcaaaaagc
    28201 taaataaaca cgaaaagtaa gtgcttatat gatgacttta gaataaatca taagttttaa
    28261 aaagatcatc ctattctata gcacttagac tgtcaatgag agaaaaacaa atgttttcat
    28321 taacaagttg gcgctttcat ggtataataa agtgctaaga cgcaattcta ttataagggg
    28381 gaatcatgga agcactcaaa aaaattgccg gtgttaccgc tgcgcaatat gtgactgatg
    28441 gcatgaccat tgggcttgga actgggtcaa cggcttacta ttttgttgag gaaattggcc
    28501 gtcgcgtaaa gcaagaagga ctgcaagtgg ttggtgtgac cacgtcaagt gtgactagca
    28561 agcaagcaga aggcttaggc attcctttaa aatcgataga tgatattgat agcattgacc
    28621 tcaccgtaga tggtgctgat gaagtggata aggatttcaa tggaatcaag ggtggtggcg
    28681 cagccttact aatggaaaaa attgttgcaa caccaacaaa agaatacatc tgggttgttg
    28741 atgcttctaa aatggtagag catctgggtg cctttaaatt accagtcgaa gtcgttcaat
    28801 atggtgctga tcgtttgttc cgtgtctttg aaaaagctgg ttacaaaccg tcttttcgta
    28861 tgaaaggtga tagtcgtttg gtgacagaca tgcaaaacta tattattgat cttgatttgg
    28921 gttgtattaa agatcctgtt gcttttggtc acctgttaga tggaacagtt ggtgttgtgg
    28981 aacacggtct ctttaatggt atggttgata aggtgattgt tgctagtaaa gacggcgtta
    29041 ctgttttaga agcgcctaaa gcaagctagt cttagcatat aacagtgtta atgtatttta
    29101 taggtattgg ggagtcaacc gtaacctccc ctagattgga gacttatgtc aaaatttaat
    29161 cgtattcact tggttgtttt agactctgtc ggtattggtg cagcaccaga tgctgacaaa
    29221 ttctttaatg ctggtgtagc tgatacagat tctgacaccc tcggtcatat ttcagaaaca
    29281 gcaggcttat cggttccaaa tatggcaaaa attggacttg gaaacatttc tcgtccaata
    29341 ccactgaaaa ctgttccaac agaagataat cctactggtt acgtgaccaa attggaagaa
    29401 gtatctcttg gaaaagatac catgacaggc cattgggaaa ttatgggctt gaacattacg
    29461 gaaccttttg acactttctg gaatggtttc ccagaagaga ttttaactaa gattgaagaa
    29521 ttctcaggcc gcaaaatcat tcgcgaggcc aacaaacctt attcaggaac tgcggttatt
    29581 gatgattttg gtccgcgtca aatagaaaca ggtgagttga ttgtttacac ctcagcagac
    29641 ccagtgcttc aaattgcagc ccatgaagac attattcctg tggaagagct ttacaagatt
    29701 tgtgaatatg ctcgctccat cacgcttgaa cgccctgccc ttttaggccg tattattgcg
    29761 cgtccttatg taggcgaacc aggaaacttt acacgtacgg ctaaccgtca tgactatgca
    29821 gtgtctcctt tccaagatac cgttttgaac aaactggctg acgcaggtgt cccaacttat
    29881 accgttggta agattaatga catctttaat ggttcaggta ttacaaacga catgggacac
    29941 aataagtcga acagccatgg tattgacacg cttattaaga ctcttcaatt acctgagttt
    30001 actaagggat tctcctttac taacctcgtt gattttgatg ccaactttgg tcatcgtcgt
    30061 gacccagagg gttatcgcga ctgcttgcat gaatttgaca atcgcctacc tgaaatcatc
    30121 gcaaatatga aagaagacga tttgcttctc atcactgctg accatggtaa tgacccaacc
    30181 tatgcaggca ccgaccacac tcgtgaatac attccattgc ttgcctactc tgcatccttt
    30241 actggaaatg gtcttattcc acaagggcat tttgcagata tttcagcgac tgttgcagaa
    30301 aactttgagg ttgatacagc catgattggg gagtcattcc ttggtcactt aaaataagaa
    30361 aattagttga taatggaaga aatcacgatt tatcataatc caaactgtgg cacttcacgt
    30421 aatgttcttg ccatgattcg ccatgcaggt attgagccta ctattattga gcctactatt
    30481 attgagtatt tgcagacgcc acctaatcgg gagactttaa ttgagctctt acaatcgatg
    30541 ggaatctctg cgcgagaact cttgcgaacc aatgttcctg aatttgaggc tcatggatta
    30601 gcaaatcaag cagtagctga gaaagacgtt attaatgcca tgttgacgga tccaattttg
    30661 atcaatcgtc ctattgttgt gactcgcaaa gaagtaaaac tttgccgtcc ttctgagacc
    30721 ttactggata ttcttcctgt tcccctgcct agtccttata tgaaagagga tggcgagagt
    30781 gtgaacccta ttgaggtaaa aggagaaaaa gatgtcattg atgactaaaa ttaacgaaac
    30841 aaaagacttt ttagttacta aaggaattga aactcccgaa tttggattaa ttctgggttc
    30901 aggccttggt gaacttgctg aagaagtaga aaatgctatt gttattgatt atgcagatat
    30961 tccaaactgg ggcaagtcaa cggttgttgg ccatgctgga aagttagttt acggagattt
    31021 agctggccgt aaagtgctcg ccttacaagg acgtttccat ttttacgaag gaaatccgct
    31081 tgaagtggtg actttccctg ttcgtgtcat gaaagctctt ggatgtgaag gcgttcttgt
    31141 cacaaatgca gctggtggta tcggctacgg cccaggtacc ttgatggcaa tcacagacca
    31201 tatcaatatg accggaaata acccactaat tggtgaaaac ttggacgagt ttggtccacg
    31261 cttccctgat atgtctgatg cctatactaa ggtttatcgc gataaggcac atgaagtggc
    31321 tgaaaaaatg aacatcaaac tagaagatgg tgtttatatg ggcttgactg gtccaactta
    31381 tgaaacacca gcagaaatcc gtgctttcaa agtattagga gcagatgctg ttggcatgtc
    31441 aactgtacca gaagttattg tggctgctca ttctggactt aaagtgcttg gcatttcagc
    31501 tattacaaac tttgcagctg gttttcaatc agaattgaac catgaagaag ttgtggaagt
    31561 gacccaacat atcaaagaag atttcaaagg tcttgttaaa gctattttag ctgagttgta
    31621 ggacgaacaa aatcaactgg agcattatta caggaatgtt attttatgtc gtcagtttgg
    31681 cacatctgtt cgcaataaaa aaatcaaaaa ataatcacgg ggtgtgagtt ctatgaatgt
    31741 tgaactcaga ttctagcttt tctaactaac ataaccaacg aagggaaaga gacgtattcg
    31801 gtttaaatta agcatggact cgaacatttc ttcgtattaa tttttaaata ataaaggaaa
    31861 gagagttagt cctttattat ttgaactcga tttttagctc tcttcttcta ttcaatatca
    31921 attatgaaag gaatggggtt gtattcaatt gaatacgggc ggaaagctcg gaaactagat
    31981 aaactaactt ttgtgctcac acatggcgtt agttccctaa atttcagttg ctttctgtcc
    32041 gccctctgac cttctacaaa ataaaaggaa aggtagggct aactgtattc attgaattga
    32101 atacgggcgg agaactgtgt aaaaaagata aactgtctag catctgggat gcgtcgtcag
    32161 tttcctattt ttactttgtt ctttgtcgcc tttaatatct taataatgtc tatccatatt
    32221 tctgccaaaa aaggtgatat tgctgataaa attcttctac ctggagaccc tttgcgcgcg
    32281 aaatttatcg ctgaaaattt cctagaagat gcagtgtgtt ttaacgaagt gcgtaacatg
    32341 tttggctaca caggaactta caaagggcac cgcgtttctg tcatgggaac tggtatgggg
    32401 atgccttcga tctctatcta tgctcgtgaa ttaatcgttg attacggtgt caaaacattg
    32461 atccgtgttg gtactgcggg tgcgattgac ccagaagttc atgtgcgtga attggtgctt
    32521 gcccaagcag cagcaaccaa ctcaaacatt atccgtaatg acttcccaga atttgatttc
    32581 ccacaaattg ctgattttgg tttacttgac aaggcttacc atatcgccag agaaatggga
    32641 gtaacaactc acgttgggaa tgtgctttct tctgatgtct tttacactaa catgcctgag
    32701 cgtaatatgg ctcttggtaa attgggtgtt aaagccatcg aaatggaagc agcagctctt
    32761 tactatttag ctgctcagca ccatgtcaaa gcccttggaa tcatgacgat ctcagataac
    32821 ttgaatgatc caaccgaaga tactacagct gaagagcgcc aaacaacttt cactgatatg
    32881 atgaaggtcg gcttggaaac tttaattgcc aatgactaat aatcaaacgc tagacatcct
    32941 tttggatgtc tatgcttata atcacgcctt tagaattgct aaagccttgc caaatatccc
    33001 taaaactgct ctctatttac tagagatgtt aaaagagcgc agagaattga accttgcctt
    33061 tctggcggaa catgcagcag agaatcggac cattgaagac cagtaccact gttcattatg
    33121 gcttaaccaa tcgcttgaag atgagcagat tgccaattac attttggatt tagaagttaa
    33181 agtaaaaaac ggtgctatta ttgatttcgt caggtcagtg tcgcctattc tttaccgact
    33241 ttttctcaga ctaatcacgt cagaaattcc aaacttcaag gcttatattt ttgatacaaa
    33301 gaatgaccaa tatgatacct ggcattttca ggccatgttg gaatctgatc acgaggtttt
    33361 caaggcttac ctgtctcaaa agcagtctcg caatgtgacg accaaaagct tagcagacat
    33421 gttgacgttg acctccttac ctcaggaaat caaggacttg gtttttttgt tacgacattt
    33481 tgaaaaggct gtccgtaatc ctctggctca tttgattaag ccttttgatg aagaggaact
    33541 gcatcgcacc actcattttt cttctcaggc ttttttggaa aacattatca ccttggcgac
    33601 tttttctggt gtaatctacc gacgtgagcc tttttacttt gatgacatga atgccattat
    33661 taaaaaggag ttgagccttt ggagacaatc tattgtctga tatttatcaa aaaacacgat
    33721 aacttgaccg atacaggtct tactaccgtg tttttttagt atgacgattg aaaaagacat
    33781 taatcaaagg ttacttcttc gagaaggtat tcgataaaac gttcccccat tttggacaag
    33841 ttggcttttt catgcttgat aaaaacaatg tcaatttcgt cagggacatc tagcgggata
    33901 gccacaatct ggtcaccatt tagattgcta tttagaatac cactggcaac ggtgtagcca
    33961 tctaaaccaa tcattaagtt aaagagggtg gcacggtcac tgaccacaat tgatttgttg
    34021 tggggcatct gggacatcat ctcttctgaa aaataaaagg agttgtgaat cccttggtca
    34081 tagctcaggt aaggaaaatc tctcaagtcg tccatgctta ataggctttt agttgctaga
    34141 ggatttgatt tgctgacaaa aatatgaggc tgtgccttaa ataatggaga ggcggtcaaa
    34201 tgattgtcat caaataattt ggtcaagaca tctcggttat agtcgttgat aaagagaaca
    34261 ccaatttcag atcgaaagtt tttgacatca tcaatgattt cccaagttct tgtctcgcgc
    34321 aaaaagagtt cataccgagt catgtcggtc cgcttgagga gtgagacaaa tgcattgact
    34381 acgaaggcat aatgttgaga tgaaacgcta aagagctctc ggccagtatt gtggttttta
    34441 tagcggtctt ctaacagtga tgtttgctct ataatttggc gagcataaga taaaaattcc
    34501 accccatctt ttgtcaaggt gatcccttta ggatttcggt tgaaaatggt aatgcccatc
    34561 tccatttcca aatccttgac cgcattggat agacttggtt gtgtgataaa taattgctta
    34621 gcagcttcat tcatagagcc gcactcaaca attttgataa tataatgcag ttgttgaatt
    34681 ctcataagta cagtctagct caaaaaaaat aaagacgcaa gcacaaacgt catcatgggt
    34741 ttagaacttt gaaaaagcgc tggcgtcttt tctcaatatg gcctaggata aatatgattc
    34801 aattttgaga gttgaatcta tcaatttcat tgccctttta tttttcttgt gttatattaa
    34861 tagtattaac aaataggtat ttttctaatc aaagggtggt ggtcgtgtga atgttactga
    34921 acaaaatagt catcaaatct taatccaaaa gttattggtc agtatccact atttgactct
    34981 ttttcgagat gaactgaagc ttgtagaacg aactccttct atacttggag gggaatttcc
    35041 agctcattta gtacagtctg agttgggaga tattgttgcg gccattgata ccttggatat
    35101 gcagcaacgc ttgattgagt ctaccttttg gtatgaagaa tcagctttta agttgatgaa
    35161 caaaactttg gatattgtcg ataattggat taaaggagtg gatcatctga tagatttatg
    35221 ccagtccaaa gaagtctttc aaattattat tggagataaa cgcattcgag tttttggggt
    35281 cttaagtgat gttttttcat ctttaaaagt gagtgctttg tcacttaagg aagctcctat
    35341 tccggatgtg ctctatgaac atatccagag ggttaatctt gaagaagaag cttttataaa
    35401 atattaccaa agccctaagg tacccacagg tgagtttgaa taaatgattg ggtaaaaatg
    35461 ataaaatgag ttgacgtaag tatacaaaaa aagatatagt aggaaagatg tgttcaaata
    35521 acaaaaagtt ttgacatctt gttttaaaaa agctataata gtttaaattt agacaccttt
    35581 aagtgagtcc agagaggcaa acaaggtata caagataaaa aaagggaatt cccttttagt
    35641 ttgctgtagc ctcgcttctt tggtagcgag gctttttggt gcttaatgag atattgacac
    35701 attatagaaa ggataagtta tgaaagaaga ccgcccaatt attgctttag acttttcatc
    35761 atttgaggag actaaagcat ttttagactt atttccagca gaagaaaaac tatacgtgaa
    35821 aattggtatg gaattatatt atgcgcaagg accagatatt gttcggtata tcaaatcgtt
    35881 agggcataat gtatttttgg atttaaaatt acatgatatt ccaaatactg ttcgtgctgc
    35941 tatggcagtt cttaaagaat tagatattga tatggcaact gttcatgcag ctggtggtgt
    36001 agagatgcta aaagcagctc gagaaggact aggtcaaggc cctaccttaa ttgcggtaac
    36061 gcagctaact tcaaccagtg aagaccaaat gcgtggtgat caaaatattc aaacgagtct
    36121 tttagagtct gttttgcatt acagcaaggg ggcagctaaa gctcagctag atggggtggt
    36181 ttgttcggca caagaagtag aagctatcaa ggcggtgacg cctacgggat ttacttgctt
    36241 aactcctggc attcgtccta aaggcagtaa tattggcgat caaaaacgag tgatgactcc
    36301 aaaccaagca agacgcattg gaagtgatta tattgtggta gggcgaccaa ttacccaggc
    36361 aaaagaccca gtggctgctt accaagccac aaaagctgag tgggcaggct aacagataag
    36421 attaggaaac caacacttgt ctgttaaaga agaaaaagga gaataagaaa tgacactagc
    36481 aagccaaatt gcaactcaat tacttgatat taaagctgtt tatttaaagc ctgaagatcc
    36541 ttttacgtgg gcatctggca ttaaatcacc tatttacact gataatcgtg tcaccctttc
    36601 ttatcctaag actcgtgatt taattgagaa tgggtttgtg gaaactatca gggctcattt
    36661 cccagaagtt gaggtcatcg ctggtacagc tacagcaggt attcctcacg gtgccattat
    36721 agcagataaa atgactcttc cttttgctta tattcgcagt aagccaaaag atcatggagc
    36781 aggcaaccag attgaggggc gtgtgcttaa aggccaaaaa atggttatca ttgaagattt
    36841 gatttcaaca ggtggttcgg tactagatgc agccgcagca gccagtcgtg agggagctga
    36901 cgttctggga gttgttgcga ttttcactta tgagttacca aaagctagtc agaattttaa
    36961 agaagctggt atcaagttga ttacgctttc taattatact gagctaattg cagttgcaaa
    37021 gttgcaaggc tatattacta atgatggttt acatttactt aaaaaattta aagaagacca
    37081 ggtaaactgg caacaataag gaactatcag ccaggtttat ttttaatgaa aaaatctctt
    37141 taaccccaat tcaaaatgtt atgttttgat tgttttgtct acattcctta cacatcacat
    37201 tctaatttct aaccttttaa tggtggtttt cttttatttg tgttttaata aaaaagaatg
    37261 ttttaggatt catatcttag aaaggaagag tagctatgac ttatcaagat gcgacggcta
    37321 tggctattgc tgttcagacc ggtcagacca caccactaga attagtaacc caggctattt
    37381 ataaggctaa aaagttgaac cctaccttaa atgctattac ctcagaacgc tttgaagcag
    37441 ccctagaaga agccaaacaa agggattttt caggtaagcc ttttgcagga gttcccattt
    37501 ttttgaaaga tttgggacaa gaattgaagg gagacttatc aacatcgggt tctaagctat
    37561 tcaagaatca tcatgcgact aaaacagatt tattcgtgaa aaggttagaa gacttgggat
    37621 ttattatttt agggcgttct aacacacctg aatttggctt taaaaatatt agtgatagtc
    37681 agctccatgg cccggtttca ttacctcatg ataatacacg aaatgctggt ggctcatctg
    37741 ggggagctgc tgctctagtg tcatcaggaa ttagtgcact agcaactgct agtgatggtg
    37801 gtggttctat tcgaattcca gcctcgttta atggcttaat tgggctcaaa cctagccgcg
    37861 ggcgcatgcc tgtcggacct ggttcttatc gaagctggca aggagcctca gttcattttg
    37921 ccttgaccaa atccgttaga gatactagaa atctactcta ctatttacag atggaacaaa
    37981 tggaaagccc cttcccccta gccaccttaa caaaaaatag tatttatcaa tcgctacaac
    38041 gtcccttgac aattgctttt tatcaacggt taagtgacgg tagcccagta tctttagata
    38101 ctgcaaaagc tttaagacaa gcagtaactt ggttaagaga acaagggcat cagctagttg
    38161 aattggaaga gtttcctgta aatatgacag aagtgattcg tcattattat attatgaata
    38221 gtgtggaaac ggctgctatg tttgctgata ttgaagacac ttttggacgt ccgatgacca
    38281 aagacgatat ggaaaccatg acctgggcta tttaccaatc aggtaaagac atcccagctt
    38341 ggcgttactc acaggtcctt caaaaatggg atacgtacag tgcaaccatg gctagttttc
    38401 atgagactta tgacctgttg ttgacgttca caaccaacac accagctcct aagcacggag
    38461 aacttgtccc agattcgaaa ctcatggcta acttggctca agctgaaatt ttcagcagtg
    38521 aagagcaatt caatttggtc gaaaccatgt ttggtaagag tctggctatt aatccttaca
    38581 cagctctgcc taatctaact ggccagccag ctattagttt acctacttac gaaactaagg
    38641 aagggctccc aatgggcatt caactaattg cagccaaagg tagagaggac ctattattag
    38701 gaattgcaga gcagtttgag gcagcaggat tattgaagat tcctcaataa taatcttata
    38761 aaacagttta actattatag attaactttt taaagagatt gagcgctcac tgataacaca
    38821 acttaatcaa aatgttatac tattcttatc ttaataaagg agttactatg aagaaatcag
    38881 ttactttact gtctatcgga cttgccagcc ttttattggc agcatgtgcg ccacataaat
    38941 ctcaaaaatc aagttgggag actatcaaag aaaaaggggt gttaaaagta gctaccccag
    39001 gaacctatca gccaacttct ttttacaacg ataataatga gttagtaggt tacgaagtag
    39061 atatggtcaa ggaaatcggt aaacgactta acattaaagt caagtttgtt gaaacaggat
    39121 ttgaccaagc ctttacctca gttgatagtg gtcgagtgga tatttctttg aacaactttg
    39181 acattacccc aaaacgtcag aaaaaataca atatctctac gccttataaa tacggggtag
    39241 gaggcatgat tgtccgtgct gatggcagct caaacatggc taaaaaagat cttagcgact
    39301 ggaaaggaaa aaaagcagct ggcgcttctg gaacagagta catgaaagta gcgcaaaaac
    39361 agggagccga actggtgacc tacgataatg ttacaggaga tgtttatcta aacgatgtgg
    39421 ctaacggtcg aacagatttc atcccaaatg attacccagc tcaaaaatta tttgtggatt
    39481 acatgttatc tcaaaatcca aatctaaatg tcaaaatgag caatgttcag tacaacccaa
    39541 ccgaacaagg aattgttatg aacaaaaaag acgatagcct caagaaaaaa atagatgctg
    39601 ttattaaaga catgataaaa gatggtagct tgaagaaaat ctctgaaacc tactatgctg
    39661 gtcaagattt gacaaaacct tttggcaaag acaaaaaaat tcccgtcatt gatacgaaag
    39721 acgttaacta atacttgatg ttaaaggagt cctaaccaca tgattaatat cccattaatg
    39781 aaagatagtt taggatttgt gttatcggga ttaccttata cccttggtat ttcgttgctc
    39841 agttttttta cgggtctgtt tttaggttta ggcctagccc ttctgggaag gtcacgtcag
    39901 ccgttgattc attatcttgt tagagcgtac atctctatta tgcgaggtgt gccgatgatc
    39961 gtggtgctct ttgttctgta tttcgggttg ccttattatg gtttagaatt gccagcttta
    40021 ctttgcgctt atcttggttt ttctatggtt agcgctgcct atatttctga agtttttcgc
    40081 tcttctatag aagctattga caagggacag tgggaagcag ctaaggcttt agggttgcca
    40141 tatgctctta tggttaagaa aattattctt cctcaagctt ttcgaattgc agttcctcct
    40201 ctaggcaatg tcattattga tatggttaaa agttcgtcgc tagctgccat gattaccgta
    40261 ccagatattt ttcaaaatgc caaaattatc ggtggtaggg agtgggacta catgtccatg
    40321 tacattttag tagcctttat ctattggatt attgcttttt tgttagaacg ttaccaagaa
    40381 ttcttagaaa ataagctagc acttgtttaa tatcctgtaa aaaacgaata ttaaccctgg
    40441 aaatatcata ttttcagggt ctttctattt aaaatgtggt aaactagata gaaaaggaca
    40501 tcgtatttaa cttagaaact gacgtgatta gaaaggaatc ttatggctca ttcaatttgg
    40561 catgagaaaa tcaaatcatt tttgccggag cattactacg gtcgcatcaa tcacttttta
    40621 gatgaagcct atgcttccgg tcttgtctac ccccaacgag aaaatgtctt taaagcctta
    40681 caagtcactc ctttggaaga aaccaaagtg ttgattttag gacaagaccc ttatcatggc
    40741 cccaaacagg cccagggctt atcattttca gttccagaag agatttctgc tccgccatcc
    40801 cttattaata ttttaaaaga attagcagat gacattggtc ctcgtgacca tcatgattta
    40861 agcacttggg ctagtcaagg ggttctgctt ttgaatgctt gcttaacagt gccagcaggc
    40921 caggctaatg ggcatgcagg cttaatatgg gagccattta cagacgctgt tattaaagtg
    40981 ctgaatgaga aagacatccc tgtagttttc attttgtggg gagcttatgc aaggaagaaa
    41041 aaagccttca ttactaatcc aaagcaccac atcatcgaga gccctcatcc aagccctttg
    41101 tcatcttatc gtggcttttt tggcagcaag cccttttcaa gaaccaacgc tattttagaa
    41161 aaagagggca tgactg
//
