Select genomic region:
Overview
3.1
7.1
9.1
10.1
12.1
19.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CAAHKK010000003.1 (Streptococcus pyogenes)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 3.1 | terpene-precursor | 88,958 | 109,830 |

NZ_CAAHKK010000007.1 (Streptococcus pyogenes)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 7.1 | RiPP-like | 28,424 | 40,306 |

NZ_CAAHKK010000009.1 (Streptococcus pyogenes)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 9.1 | T3PKS | 28,880 | 70,055 |

NZ_CAAHKK010000010.1 (Streptococcus pyogenes)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 10.1 | azole-containing-RiPP | 67,855 | 83,271 | High | streptolysin S | ribosomal:RiPP:LAP

NZ_CAAHKK010000012.1 (Streptococcus pyogenes)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 12.1 | lanthipeptide-class-i | 61,344 | 79,926 | High | streptin | ribosomal:RiPP:Lanthipeptide

NZ_CAAHKK010000019.1 (Streptococcus pyogenes)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 19.1 | lanthipeptide-class-ii | 1 | 11,553 | High | streptococcin A-FF22 | ribosomal:RiPP:Lanthipeptide

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 3.1 | terpene-precursor | 88,958 | 109,830 |
Region 7.1 | RiPP-like | 28,424 | 40,306 |
Region 9.1 | T3PKS | 28,880 | 70,055 |
Region 10.1 | azole-containing-RiPP | 67,855 | 83,271 | High | streptolysin S | ribosomal:RiPP:LAP
Region 12.1 | lanthipeptide-class-i | 61,344 | 79,926 | High | streptin | ribosomal:RiPP:Lanthipeptide
Region 19.1 | lanthipeptide-class-ii | 1 | 11,553 | High | streptococcin A-FF22 | ribosomal:RiPP:Lanthipeptide

No secondary metabolite regions were found in these records:
  NZ_CAAHKK010000001.1 (Streptococcus pyogenes)
  NZ_CAAHKK010000002.1 (Streptococcus pyogenes)
  NZ_CAAHKK010000004.1 (Streptococcus pyogenes)
  NZ_CAAHKK010000005.1 (Streptococcus pyogenes)
  NZ_CAAHKK010000006.1 (Streptococcus pyogenes)
  NZ_CAAHKK010000008.1 (Streptococcus pyogenes)
  NZ_CAAHKK010000011.1 (Streptococcus pyogenes)
  NZ_CAAHKK010000013.1 (Streptococcus pyogenes)
  NZ_CAAHKK010000014.1 (Streptococcus pyogenes)
  NZ_CAAHKK010000015.1 (Streptococcus pyogenes)
  NZ_CAAHKK010000016.1 (Streptococcus pyogenes)
  NZ_CAAHKK010000017.1 (Streptococcus pyogenes)
  NZ_CAAHKK010000018.1 (Streptococcus pyogenes)
  NZ_CAAHKK010000020.1 (Streptococcus pyogenes)
  NZ_CAAHKK010000021.1 (Streptococcus pyogenes)
  NZ_CAAHKK010000022.1 (Streptococcus pyogenes)

Compact view
NZ_CAAHKK010000003.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 88,958 - 109,830 nt. (total: 20,873 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Ligases: synthetase
E9649_RS02550: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002698.2 |  | 0.40 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0000487.5 |  | 0.36 | ribosomal | carnocyclin | Carnobacterium maltaromaticum
BGC0000542.3 |  | 0.33 | ribosomal | paenicidin B | Paenibacillus terrae
BGC0000541.5 |  | 0.33 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0000502.5 |  | 0.33 | ribosomal | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus
BGC0001859.4 |  | 0.32 | other (phosphonate) | fosfomycin | Pseudomonas syringae
BGC0000617.5 |  | 0.32 | ribosomal | coagulin | Bacillus coagulans

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002698.2 |  | 0.40 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0000487.5 |  | 0.36 | ribosomal | carnocyclin | Carnobacterium maltaromaticum
BGC0000542.3 |  | 0.33 | ribosomal | paenicidin B | Paenibacillus terrae
BGC0000541.5 |  | 0.33 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0000502.5 |  | 0.33 | ribosomal | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus
BGC0001859.4 |  | 0.32 | other (phosphonate) | fosfomycin | Pseudomonas syringae
BGC0000617.5 |  | 0.32 | ribosomal | coagulin | Bacillus coagulans

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
E9649_RS02550: PT_FPPS_like
Domain 1 (25 - 272): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  DMAPP, IPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.93 out of 26.33
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.16 out of 20.97
Confidence: medium
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.00 out of 26.85
Confidence: medium
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 26.23 out of 28.14
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.55 out of 23.79
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.54 out of 28.19
Confidence: medium
Additional weak hits (4):
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.95 out of 39.62
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.91 out of 32.74
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.13 out of 25.75
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.81 out of 30.25
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
CcpA | Catabolite control protein A
IolR | Regulator of the inositol catabolism
PerR | Peroxide regulator
RutR | Regulator of the pyrimidine and purine metabolism
ZuR variant 1 | Zinc-responsive repressor

NZ_CAAHKK010000007.1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 28,424 - 40,306 nt. (total: 11,883 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000526.5 |  | 0.22 | ribosomal | macedocin | Streptococcus macedonicus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000526.5 |  | 0.22 | ribosomal | macedocin | Streptococcus macedonicus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.93 out of 26.33
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.12 out of 23.79
Confidence: medium
Additional weak hits (1):
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.57 out of 26.85
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
IolR | Regulator of the inositol catabolism

NZ_CAAHKK010000009.1 - Region 1 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 28,880 - 70,055 nt. (total: 41,176 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: reductase
E9649_RS05585: hydroxymethylglutaryl-CoA reductase

smcogs
  SMCOG1187: hydroxymethylglutaryl-CoA reductase

Hydrolases: amidase deformylase esterase
E9649_RS05540: peptide deformylase

smcogs
  SMCOG1275: peptide deformylase

E9649_RS05545: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

smcogs
  SMCOG1283: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

E9649_RS05680: amidase

smcogs
  SMCOG1105: amidase

Ligases: synthase
E9649_RS05590: hydroxymethylglutaryl-CoA synthase

smcogs
  SMCOG1043: hydroxymethylglutaryl-CoA synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002561.3 |  | 0.45 | other (other) | phenazine SA, phenazine SB, phenazine SC | Streptomyces sp.
BGC0000934.4 |  | 0.41 | other (phenazine) | 5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G | Kitasatospora sp. HKI 714
BGC0001080.5 |  | 0.41 | other (phenazine) | endophenazine A, endophenazine B | Streptomyces anulatus
BGC0000286.3 |  | 0.40 | PKS | viguiepinol | Streptomyces sp. KO-3988
BGC0002284.3 |  | 0.39 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000489.3 |  | 0.39 | ribosomal | enterocin AS-48 | Enterococcus faecalis
BGC0001863.4 |  | 0.38 | ribosomal, terpene | bacillicn CER074 | Bacillus mycoides
BGC0002362.3 |  | 0.38 | PKS | loseolamycin A1, loseolamycin A2 | Micromonospora endolithica
BGC0002701.2 |  | 0.38 | ribosomal | paenithipeptin | Paenibacillus thiaminolyticus
BGC0001521.3 |  | 0.38 | NRPS | auriculamide | Herpetosiphon aurantiacus DSM 785

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002561.3 |  | 0.45 | other (other) | phenazine SA, phenazine SB, phenazine SC | Streptomyces sp.
BGC0000934.4 |  | 0.41 | other (phenazine) | 5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G | Kitasatospora sp. HKI 714
BGC0001080.5 |  | 0.41 | other (phenazine) | endophenazine A, endophenazine B | Streptomyces anulatus
BGC0000286.3 |  | 0.40 | PKS | viguiepinol | Streptomyces sp. KO-3988
BGC0002284.3 |  | 0.39 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000489.3 |  | 0.39 | ribosomal | enterocin AS-48 | Enterococcus faecalis
BGC0001863.4 |  | 0.38 | ribosomal, terpene | bacillicn CER074 | Bacillus mycoides
BGC0002362.3 |  | 0.38 | PKS | loseolamycin A1, loseolamycin A2 | Micromonospora endolithica
BGC0002701.2 |  | 0.38 | ribosomal | paenithipeptin | Paenibacillus thiaminolyticus
BGC0001521.3 |  | 0.38 | NRPS | auriculamide | Herpetosiphon aurantiacus DSM 785

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.38 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.62 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.36 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.33 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.93 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.30 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.77 out of 27.78
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.20 out of 24.78
Confidence: medium
Additional weak hits (1):
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.77 out of 28.14
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes

NZ_CAAHKK010000010.1 - Region 1 - azole-containing-RiPP
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 67,855 - 83,271 nt. (total: 15,417 nt) Show pHMM detection rules used
Region on contig edge.
azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Azole RiPPs
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | azole-containing-RiPP | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000566.5 |  | 0.99 | ribosomal | streptolysin S | Streptococcus pyogenes M1 GAS
BGC0000564.5 |  | 0.69 | ribosomal | clostridiolysin S | Clostridium botulinum A str. ATCC 3502
BGC0001170.5 |  | 0.64 | ribosomal | clostridiolysin S | Clostridium sporogenes ATCC 15579
BGC0001171.5 |  | 0.50 | ribosomal | listeriolysin S | Listeria monocytogenes serotype 4b str. F2365
BGC0000569.5 |  | 0.49 | ribosomal | plantazolicin | Bacillus velezensis FZB42
BGC0001173.5 |  | 0.48 | ribosomal | plantazolicin | Bacillus pumilus ATCC 7061
BGC0002700.2 |  | 0.41 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0000605.5 |  | 0.40 | ribosomal | GE37468 | Streptomyces sp. ATCC 55365
BGC0001887.3 |  | 0.39 | ribosomal | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0002111.3 |  | 0.39 | ribosomal | andalusicin A, andalusicin B | Bacillus thuringiensis serovar andalousiensis NRRL B-23139

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000566.5 |  | 0.99 | ribosomal | streptolysin S | Streptococcus pyogenes M1 GAS
BGC0000564.5 |  | 0.69 | ribosomal | clostridiolysin S | Clostridium botulinum A str. ATCC 3502
BGC0001170.5 |  | 0.64 | ribosomal | clostridiolysin S | Clostridium sporogenes ATCC 15579
BGC0001171.5 |  | 0.50 | ribosomal | listeriolysin S | Listeria monocytogenes serotype 4b str. F2365
BGC0000569.5 |  | 0.49 | ribosomal | plantazolicin | Bacillus velezensis FZB42
BGC0001173.5 |  | 0.48 | ribosomal | plantazolicin | Bacillus pumilus ATCC 7061
BGC0002700.2 |  | 0.41 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0000605.5 |  | 0.40 | ribosomal | GE37468 | Streptomyces sp. ATCC 55365
BGC0001887.3 |  | 0.39 | ribosomal | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0002111.3 |  | 0.39 | ribosomal | andalusicin A, andalusicin B | Bacillus thuringiensis serovar andalousiensis NRRL B-23139

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.98 out of 20.97
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.45 out of 26.06
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.03 out of 20.97
Confidence: medium
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.06 out of 18.46
Confidence: medium
Additional weak hits (3):
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.72 out of 30.22
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.53 out of 33.73
Confidence: weak
NrdR
Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.38 out of 27.18
Confidence: weak
(Thi)azol(in)e containing peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Predicted tail sequences are also shown, if present.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
No core peptides found.
RREFinder
TFBS Finder
Azole RiPPs
RRE predictions
RREfinder results sidepanel.

azole-containing-RiPP protocluster (67854...83271)
E9649_RS06220
  RRE type: Cytolysin_C_RRE
  Location: 0 - 90
  Score: 133.3

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
MogR | Repressor of flagellar motility genes
RpoN | Regulator of nitrogen assimilation and virulence

Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.
NZ_CAAHKK010000012.1 - Region 1 - lanthipeptide-class-i
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 61,344 - 79,926 nt. (total: 18,583 nt) Show pHMM detection rules used
Region on contig edge.
lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: dehydratase
E9649_RS06995: Lantibiotic dehydratase domain protein

smcogs
  SMCOG1155: Lantibiotic dehydratase domain protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-i | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000556.5 |  | 0.95 | ribosomal | streptin | Streptococcus pyogenes
BGC0000538.3 |  | 0.56 | ribosomal | nisin Z | Lactococcus lactis
BGC0000541.5 |  | 0.53 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0000542.3 |  | 0.53 | ribosomal | paenicidin B | Paenibacillus terrae
BGC0000559.4 |  | 0.52 | ribosomal | subtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000626.3 |  | 0.50 | ribosomal | thuricin | Bacillus thuringiensis
BGC0001289.5 |  | 0.50 | ribosomal | penisin | Paenibacillus ehimensis
BGC0002323.2 |  | 0.49 | ribosomal | nisin J | Staphylococcus capitis
BGC0000537.3 |  | 0.49 | ribosomal | nisin U | Streptococcus uberis
BGC0001789.3 |  | 0.49 | ribosomal | suicin 90-1330 | Streptococcus suis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000556.5 |  | 0.95 | ribosomal | streptin | Streptococcus pyogenes
BGC0000538.3 |  | 0.56 | ribosomal | nisin Z | Lactococcus lactis
BGC0000541.5 |  | 0.53 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0000542.3 |  | 0.53 | ribosomal | paenicidin B | Paenibacillus terrae
BGC0000559.4 |  | 0.52 | ribosomal | subtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000626.3 |  | 0.50 | ribosomal | thuricin | Bacillus thuringiensis
BGC0001289.5 |  | 0.50 | ribosomal | penisin | Paenibacillus ehimensis
BGC0002323.2 |  | 0.49 | ribosomal | nisin J | Staphylococcus capitis
BGC0000537.3 |  | 0.49 | ribosomal | nisin U | Streptococcus uberis
BGC0001789.3 |  | 0.49 | ribosomal | suicin 90-1330 | Streptococcus suis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
Lanthipeptides - No core peptides found.
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.71 out of 20.97
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26
Confidence: medium
Lanthipeptides
RREFinder
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.
No core peptides found.
RRE predictions
RREfinder results sidepanel.

lanthipeptide-class-i protocluster (61343...79926)
E9649_RS06995
  RRE type: Lanthipeptide_LanB_RRE
  Location: 134 - 219
  Score: 41.5

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
CcpA | Catabolite control protein A

NZ_CAAHKK010000019.1 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 11,553 nt. (total: 11,553 nt) Show pHMM detection rules used
Region on contig edge.
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase
E9649_RS08775: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000557.5 |  | 0.93 | ribosomal | streptococcin A-FF22 | Streptococcus pyogenes
BGC0001788.3 |  | 0.83 | ribosomal | suicin 65 | Streptococcus suis
BGC0000550.3 |  | 0.82 | ribosomal | salivaricin G32 | Streptococcus salivarius
BGC0000526.5 |  | 0.80 | ribosomal | macedocin | Streptococcus macedonicus
BGC0000562.3 |  | 0.75 | ribosomal | variacin | Kocuria varians
BGC0000547.5 |  | 0.69 | ribosomal | salivaricin 9 | Streptococcus salivarius
BGC0000534.3 |  | 0.65 | ribosomal | mutacin K8 | Streptococcus mutans
BGC0000521.3 |  | 0.61 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000499.3 |  | 0.58 | ribosomal | butyrivibriocin OR79 | Butyrivibrio fibrisolvens
BGC0000532.3 |  | 0.57 | ribosomal | mutacin II | Streptococcus mutans

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000557.5 |  | 0.93 | ribosomal | streptococcin A-FF22 | Streptococcus pyogenes
BGC0001788.3 |  | 0.83 | ribosomal | suicin 65 | Streptococcus suis
BGC0000550.3 |  | 0.82 | ribosomal | salivaricin G32 | Streptococcus salivarius
BGC0000526.5 |  | 0.80 | ribosomal | macedocin | Streptococcus macedonicus
BGC0000562.3 |  | 0.75 | ribosomal | variacin | Kocuria varians
BGC0000547.5 |  | 0.69 | ribosomal | salivaricin 9 | Streptococcus salivarius
BGC0000534.3 |  | 0.65 | ribosomal | mutacin K8 | Streptococcus mutans
BGC0000521.3 |  | 0.61 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000499.3 |  | 0.58 | ribosomal | butyrivibriocin OR79 | Butyrivibrio fibrisolvens
BGC0000532.3 |  | 0.57 | ribosomal | mutacin II | Streptococcus mutans

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for E9649_RS08775

E9649_RS08760
Leader:
MEKNNEVINSIQEVSLEELDQIIGA
E9649_RS08765
Leader:
MTKEHEIINSIQEVSLEELDQIIGA
Shared core:
G K N G V F K T I S H E C H L N T W A F L A T C C S
Core with dehydrations:
G K N G V F K Dhb I Dha H E Cys H L N Dhb W A F L A Dhb Cys Cys Dha

#### antiSMASH-DB 4.0 matches for E9649_RS08760

100.0%
NZ_ALSD01000046.1 and 49 others:
NZ_CAAHGW010000010.1 Lanthipeptides: E9435_RS08890_lanthipeptide NZ_CAAHHE010000002.1 Lanthipeptides: E9499_RS02935_lanthipeptide NZ_CAAHHF010000009.1 Lanthipeptides: E9478_RS08685_lanthipeptide NZ_CAAHHF010000009.1 Lanthipeptides: E9478_RS08680_lanthipeptide NZ_CAAHHN010000003.1 Lanthipeptides: E9502_RS05700_lanthipeptide NZ_CAAHHU010000009.1 Lanthipeptides: E9510_RS08730_lanthipeptide NZ_CAAHHU010000009.1 Lanthipeptides: E9510_RS08725_lanthipeptide NZ_CAAHHW010000012.1 Lanthipeptides: E9525_RS08980_lanthipeptide NZ_CAAHHW010000012.1 Lanthipeptides: E9525_RS08975_lanthipeptide NZ_CAAHIB010000001.1 Lanthipeptides: E9539_RS01070_lanthipeptide NZ_CAAHIV010000024.1 Lanthipeptides: E9612_RS09265_lanthipeptide NZ_CAAHIV010000024.1 Lanthipeptides: E9612_RS09260_lanthipeptide NZ_CAAHKK010000019.1 Lanthipeptides: E9649_RS08765_lanthipeptide NZ_CAAHKK010000019.1 Lanthipeptides: E9649_RS08760_lanthipeptide NZ_CAAHKP010000014.1 Lanthipeptides: E9652_RS08915_lanthipeptide NZ_CAAHKP010000014.1 Lanthipeptides: E9652_RS08910_lanthipeptide NZ_CAAHKQ010000003.1 Lanthipeptides: E9664_RS02170_lanthipeptide NZ_CAAHKY010000014.1 Lanthipeptides: E9668_RS09655_lanthipeptide NZ_CAAHLP010000002.1 Lanthipeptides: E9684_RS03455_lanthipeptide NZ_CAAHLP010000002.1 Lanthipeptides: E9684_RS03450_lanthipeptide NZ_CAAHQE010000012.1 Lanthipeptides: E9931_RS08825_lanthipeptide NZ_CAAHQE010000012.1 Lanthipeptides: E9931_RS08820_lanthipeptide NZ_CAAHRY010000002.1 Lanthipeptides: E9986_RS03170_lanthipeptide NZ_CAAIES010000002.1 Lanthipeptides: FAH15_RS02470_lanthipeptide NZ_CAAIIA010000012.1 Lanthipeptides: FAH55_RS08470_lanthipeptide NZ_CAAIIA010000012.1 Lanthipeptides: FAH55_RS08465_lanthipeptide NZ_CAAIJM010000015.1 Lanthipeptides: FAI23_RS09580_lanthipeptide NZ_CAAINV010000013.1 Lanthipeptides: FAI86_RS09035_lanthipeptide NZ_CAAINV010000013.1 Lanthipeptides: FAI86_RS09030_lanthipeptide NZ_CAAIRS010000012.1 Lanthipeptides: FAK24_RS08495_lanthipeptide NZ_CAAIRS010000012.1 Lanthipeptides: FAK24_RS08490_lanthipeptide NZ_CAAJFI010000013.1 Lanthipeptides: FAP60_RS08505_lanthipeptide NZ_CAAJFI010000013.1 Lanthipeptides: FAP60_RS08500_lanthipeptide NZ_CAJHJS010000009.1 Lanthipeptides: JMX87_RS06790_lanthipeptide NZ_CAJHJS010000009.1 Lanthipeptides: JMX87_RS06785_lanthipeptide NZ_CM001076.1 Lanthipeptides: SDD27957_RS04310_lanthipeptide NZ_CM001076.1 Lanthipeptides: SDD27957_RS04305_lanthipeptide NZ_CP035426.1 Lanthipeptides: ETT73_RS02595_lanthipeptide NZ_CP035426.1 Lanthipeptides: ETT73_RS02590_lanthipeptide NZ_CP035428.1 Lanthipeptides: ETT71_RS02815_lanthipeptide NZ_CP035437.1 Lanthipeptides: ETT62_RS06680_lanthipeptide NZ_CP035437.1 Lanthipeptides: ETT62_RS06675_lanthipeptide NZ_CP035443.1 Lanthipeptides: ETT56_RS07265_lanthipeptide NZ_GL636070.1 Lanthipeptides: HMPREF9171_RS105315_lanthipeptide NZ_LR793258.1 Lanthipeptides: HV369_RS03145_lanthipeptide NZ_LR793258.1 Lanthipeptides: HV369_RS03140_lanthipeptide NZ_LS483425.1 Lanthipeptides: DQN36_RS06755_lanthipeptide NZ_LS483425.1 Lanthipeptides: DQN36_RS06750_lanthipeptide NZ_LT545678.1 Lanthipeptides: BJR96_RS07040_lanthipeptide
Lanthipeptides: SAG0161_RS120605_lanthipeptide
1
G K N G V F K T I S H E C H L N T W A F L A T C C S
26
G K N G V F K T I S H E C H L N T W A F L A T C C S
1
G K N G V F K T I S H E C H L N T W A F L A T C C S
26
96.2%
NZ_CAAHKQ010000003.1:
Lanthipeptides: E9664_RS02165_lanthipeptide
1
G K N G V F K T I S H E C H L N T W A F L A T C C S
26
G K N G V F K T I S H E C H L N T W A F L A C C S
1
G K N G V F K T I S H E C H L N T W A F L A I C C S
26
96.2%
NZ_CP060646.1:
Lanthipeptides: H7789_RS06845_lanthipeptide
1
G K N G V F K T I S H E C H L N T W A F L A T C C S
26
G K N G V F K T I S H E C H L N T W A L A T C C S
1
G K N G V F K T I S H E C H L N T W A S L A T C C S
26
with 78 more sequence matches
Only the first 10 are displayed here.
92.3%
NZ_CP018188.1 and 17 others:
NZ_CP018188.1 Lanthipeptides: BSR19_RS11175_lanthipeptide NZ_CP066093.1 Lanthipeptides: I6I02_RS07300_lanthipeptide NZ_CP066093.1 Lanthipeptides: I6I02_RS07295_lanthipeptide NZ_JALDUD010000010.1 Lanthipeptides: M1G10_RS09705_lanthipeptide NZ_JALDUD010000010.1 Lanthipeptides: M1G10_RS09700_lanthipeptide NZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09300_lanthipeptide NZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09295_lanthipeptide NZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09300_lanthipeptide NZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09295_lanthipeptide NZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06585_lanthipeptide NZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06580_lanthipeptide NZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06585_lanthipeptide NZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06580_lanthipeptide NZ_KV832031.1 Lanthipeptides: HMPREF2637_RS05120_lanthipeptide NZ_KV832031.1 Lanthipeptides: HMPREF2637_RS05115_lanthipeptide NZ_PKIA01000004.1 Lanthipeptides: CYK22_RS04335_lanthipeptide NZ_PKIA01000004.1 Lanthipeptides: CYK22_RS04330_lanthipeptide
Lanthipeptides: BSR19_RS11180_lanthipeptide
3
N G V F K T I S H E C H L N T W A F L A T C C S
26
N G V F K T I S H E C H L N T W A F L A T C C S
2
N G V F K T I S H E C H L N T W A F L A T C C S
25
84.6%
NC_012470.1 and 11 others:
NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS06485_lanthipeptide NZ_CP029398.1 Lanthipeptides: DF184_RS05185_lanthipeptide NZ_CP029398.1 Lanthipeptides: DF184_RS05180_lanthipeptide NZ_CP078012.1 Lanthipeptides: KV238_RS09835_lanthipeptide NZ_CP078012.1 Lanthipeptides: KV238_RS09830_lanthipeptide NZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05350_lanthipeptide NZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05345_lanthipeptide NZ_LR738724.1 Lanthipeptides: GPW69_RS05065_lanthipeptide NZ_LR738724.1 Lanthipeptides: GPW69_RS05060_lanthipeptide NZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05580_lanthipeptide NZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05575_lanthipeptide
Lanthipeptides: SZO_RS04070_lanthipeptide
1
G K N G V F K T I S H E C H L N T W A F L A T C C S
26
G K N G V F K T I S H E C H+N+W F L T C C S
1
G K N G V F K T I S H E C H M N S W Q F L F T C C S
26
76.9%
NC_012470.1 and 2 others:
NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS06490_lanthipeptide NZ_CP078012.1 Lanthipeptides: KV238_RS09840_lanthipeptide
Lanthipeptides: SZO_RS04065_lanthipeptide
1
G K N G V F K T I S H E C H L N T W A F L A T C C S
26
G K N G K T I S H E C H+N+W F L T C C S
1
G K N G A I K T I S H E C H M N S W Q F L F T C C S
26
76.9%
NZ_AP025017.1:
Lanthipeptides: MANAM107_RS05920_lanthipeptide
3
N G V F K T I S H E C H L N T W A F L A T C C S
26
N G V T I S H E C H L N T W A F T C C S
1
N G V I T T I S H E C H L N T W A F A F T C C S
24
76.9%
NZ_NWMU01000024.1 and 3 others:
NZ_NWMU01000024.1 Lanthipeptides: CO197_RS09145_lanthipeptide NZ_VMMF01000004.1 Lanthipeptides: HT717_RS01575_lanthipeptide NZ_VMMF01000004.1 Lanthipeptides: HT717_RS01570_lanthipeptide
Lanthipeptides: CO197_RS09150_lanthipeptide
1
G K N G V F K T I S H E C H L N T W A F L A T C C S
26
G K N G V F K T I S H E C H+N++ F T C C S
1
G K N G V F K T I S H E C H M N S F Q F F F T C C S
26
69.2%
NZ_CP023483.1:
Lanthipeptides: CNY62_RS11970_lanthipeptide
3
N G V F K T I S H E C H L N T W A F L A T C C S
26
N G +T I S H E C H+N T W F L T C C S
2
N G A I R T I S H E C H M N T W Q F L F T C C S
25
69.2%
NZ_CP084014.1 and 6 others:
NZ_CP084014.1 Lanthipeptides: LCQ72_RS00100_lanthipeptide NZ_CP084014.1 Lanthipeptides: LCQ72_RS00095_lanthipeptide NZ_CP094679.1 Lanthipeptides: K5I24_RS13105_lanthipeptide NZ_JAQEYW010000015.1 Lanthipeptides: PG422_RS12415_lanthipeptide NZ_JAQEYW010000015.1 Lanthipeptides: PG422_RS12410_lanthipeptide NZ_JAQEYW010000015.1 Lanthipeptides: PG422_RS12405_lanthipeptide
Lanthipeptides: LCQ72_RS00105_lanthipeptide
3
N G V F K T I S H E C H L N T W A F L A T C C
25
N G V K T I S H E C++N T W F L T C C
2
N G V L K T I S H E C N M N T W Q F L F T C C
24
69.2%
NZ_FOZB01000002.1:
Lanthipeptides: BM306_RS07850_lanthipeptide
3
N G V F K T I S H E C H L N T W A F L A T C C S
26
+G V F+T I S H E C H+N T W F+ T C C S
2
D G V F R T I S H E C H M N T W M F I F T C C S
25
69.2%
NZ_LT732526.1 and 1 other:
NZ_LT732526.1 Lanthipeptides: BQ9856_RS23075_lanthipeptide
Lanthipeptides: BQ9856_RS23080_lanthipeptide
3
N G V F K T I S H E C H L N T W A F L A T C C S
26
N G V K T I S H E C +N T W F+ T C C S
2
N G V I K T I S H E C A M N T W Q F I F T C C S
25
69.2%
NZ_WBPF01000002.1:
Lanthipeptides: F8162_RS00195_lanthipeptide
2
K N G V F K T I S H E C H L N T W A F L A T C C S
26
G F T I S H E C H N T W F L T C C S
1
D K G Q F D T I S H E C H W N T W Q F L F T C C S
25

#### MIBiG 4.0 matches for E9649_RS08760

23.3%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
1
G K N G V F K T I S H E C H L N
16
G N G + T++ E C N
13
G N N G G W C T L T K E C Q P N
28
12.8%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
8
T I S H E C H L N
16
T+S E C N
29
T L S K E C Q P N
37
E9649_RS08770
Leader:
MEEKMCLGALNALQEFQIEELDNLLGG
Core:
R G H G V N T I S A E C R W N S L Q A I F T C C
Core with dehydrations:
R G H G V N Dhb I Dha A E Cys R W N Dha L Q A I F Dhb Cys Cys

#### antiSMASH-DB 4.0 matches for E9649_RS08770

100.0%
NZ_CAAHGW010000010.1 and 11 others:
NZ_CAAHKK010000019.1 Lanthipeptides: E9649_RS08770_lanthipeptide NZ_CAAHKQ010000003.1 Lanthipeptides: E9664_RS02160_lanthipeptide NZ_CAAHQE010000012.1 Lanthipeptides: E9931_RS08815_lanthipeptide NZ_CAAIIA010000012.1 Lanthipeptides: FAH55_RS08475_lanthipeptide NZ_CAAINV010000013.1 Lanthipeptides: FAI86_RS09025_lanthipeptide NZ_CAAJFI010000013.1 Lanthipeptides: FAP60_RS08495_lanthipeptide NZ_CP035426.1 Lanthipeptides: ETT73_RS02600_lanthipeptide NZ_CP035437.1 Lanthipeptides: ETT62_RS06670_lanthipeptide NZ_CP035443.1 Lanthipeptides: ETT56_RS07260_lanthipeptide NZ_LS483425.1 Lanthipeptides: DQN36_RS06745_lanthipeptide NZ_NWMU01000024.1 Lanthipeptides: CO197_RS09155_lanthipeptide
Lanthipeptides: E9435_RS08895_lanthipeptide
1
R G H G V N T I S A E C R W N S L Q A I F T C C
24
R G H G V N T I S A E C R W N S L Q A I F T C C
1
R G H G V N T I S A E C R W N S L Q A I F T C C
24
95.8%
NC_012470.1 and 29 others:
NZ_CAAHHE010000002.1 Lanthipeptides: E9499_RS02930_lanthipeptide NZ_CAAHHF010000009.1 Lanthipeptides: E9478_RS08675_lanthipeptide NZ_CAAHHN010000003.1 Lanthipeptides: E9502_RS05705_lanthipeptide NZ_CAAHHU010000009.1 Lanthipeptides: E9510_RS08735_lanthipeptide NZ_CAAHHW010000012.1 Lanthipeptides: E9525_RS08985_lanthipeptide NZ_CAAHIB010000001.1 Lanthipeptides: E9539_RS01075_lanthipeptide NZ_CAAHIV010000024.1 Lanthipeptides: E9612_RS09255_lanthipeptide NZ_CAAHKP010000014.1 Lanthipeptides: E9652_RS08920_lanthipeptide NZ_CAAHKY010000014.1 Lanthipeptides: E9668_RS09650_lanthipeptide NZ_CAAHLP010000002.1 Lanthipeptides: E9684_RS03445_lanthipeptide NZ_CAAHRY010000002.1 Lanthipeptides: E9986_RS03175_lanthipeptide NZ_CAAIES010000002.1 Lanthipeptides: FAH15_RS02475_lanthipeptide NZ_CAAIJM010000015.1 Lanthipeptides: FAI23_RS09585_lanthipeptide NZ_CAAIRS010000012.1 Lanthipeptides: FAK24_RS08485_lanthipeptide NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS10120_lanthipeptide NZ_CP018188.1 Lanthipeptides: BSR19_RS11185_lanthipeptide NZ_CP029398.1 Lanthipeptides: DF184_RS05190_lanthipeptide NZ_CP066093.1 Lanthipeptides: I6I02_RS07305_lanthipeptide NZ_CP078012.1 Lanthipeptides: KV238_RS09825_lanthipeptide NZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05340_lanthipeptide NZ_JALDUD010000010.1 Lanthipeptides: M1G10_RS09695_lanthipeptide NZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09305_lanthipeptide NZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09305_lanthipeptide NZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06590_lanthipeptide NZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06590_lanthipeptide NZ_KV832031.1 Lanthipeptides: HMPREF2637_RS10860_lanthipeptide NZ_LR738724.1 Lanthipeptides: GPW69_RS05070_lanthipeptide NZ_PKIA01000004.1 Lanthipeptides: CYK22_RS04325_lanthipeptide NZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05570_lanthipeptide
Lanthipeptides: SZO_RS10260_lanthipeptide
2
G H G V N T I S A E C R W N S L Q A I F T C C
24
G H G V N T I S A E C R W N S L Q A I F T C C
2
G H G V N T I S A E C R W N S L Q A I F T C C
24
92.0%
NZ_VMMF01000004.1:
Lanthipeptides: HT717_RS01580_lanthipeptide
1
R G H G V N T I S A E C R W N S L Q A I F T C C
24
+G H G V N T I S A E C R W N S L Q A I F T C C
2
K G H G V N T I S A E C R W N S L Q A I F T C C
25
with 47 more sequence matches
Only the first 10 are displayed here.
91.7%
NZ_ALSD01000046.1 and 5 others:
NZ_CAJHJS010000009.1 Lanthipeptides: JMX87_RS06795_lanthipeptide NZ_CM001076.1 Lanthipeptides: SDD27957_RS10995_lanthipeptide NZ_GL636070.1 Lanthipeptides: HMPREF9171_RS1000000113590_lanthipeptide NZ_LR793258.1 Lanthipeptides: HV369_RS03150_lanthipeptide NZ_LT545678.1 Lanthipeptides: BJR96_RS11590_lanthipeptide
Lanthipeptides: SAG0161_RS1000000124770_lanthipeptide
2
G H G V N T I S A E C R W N S L Q A I F T C C
24
G H G V N T I S A E C R W N S L Q A I F+C C
2
G H G V N T I S A E C R W N S L Q A I F S C C
24
70.8%
NC_013928.1 and 4 others:
NZ_CP023477.1 Lanthipeptides: CO204_RS01890_lanthipeptide NZ_CP050270.1 Lanthipeptides: HB753_RS01095_lanthipeptide NZ_CP061071.1 Lanthipeptides: IBL27_RS01750_lanthipeptide NZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS07560_lanthipeptide
Lanthipeptides: SMUNN2025_RS09965_lanthipeptide
2
G H G V N T I S A E C R W N S L Q A I F T C C
24
G N T I S++C R W N S L Q A I F+C C
2
G R A S N T I S S D C R W N S L Q A I F S C C
24
64.0%
NZ_JAEEGA010000010.1:
Lanthipeptides: I6N95_RS15660_lanthipeptide
2
G H G V-N T I S A E C R W N S L Q A I F T C C
24
G+G V T I S E C N S Q I F T C C
1
G N G V I K T I S H E C H M N S W Q W I F T C C
24
62.5%
NZ_GL985606.1:
Lanthipeptides: HMPREF9062_RS00700_lanthipeptide
2
G H G V-N T I S A E C R W N S L Q A I F T C C
24
G+G V +T I S E C +N S I F T C C
1
G N G V F H T I S H E C Y Y N S W A F I F T C C
24
62.5%
NZ_QTVL01000002.1 and 5 others:
NZ_QTVL01000002.1 Lanthipeptides: DWZ44_RS04150_lanthipeptide NZ_QTZB01000015.1 Lanthipeptides: DXC15_RS14340_lanthipeptide NZ_QTZB01000015.1 Lanthipeptides: DXC15_RS14335_lanthipeptide NZ_QUKU01000003.1 Lanthipeptides: DXC27_RS02940_lanthipeptide NZ_QUKU01000003.1 Lanthipeptides: DXC27_RS02935_lanthipeptide
Lanthipeptides: DWZ44_RS04155_lanthipeptide
2
G H G V-N T I S A E C R W N S L Q A I F T C C
24
G G V T I S E C N+ Q I F T C C
1
G D G V F R T I S H E C N M N T W Q F I F T C C
24
60.0%
NZ_GL882519.1:
Lanthipeptides: HMPREF9056_RS03330_lanthipeptide
2
G H G V N-T I S A E C R W N S L Q A I F T C C
24
G+G V T+S E C N S Q I F T C C
1
G N G V Y Y T L S H E C H M N S W Q F I F T C C
24
60.0%
NZ_LT732526.1 and 1 other:
NZ_LT732526.1 Lanthipeptides: BQ9856_RS23075_lanthipeptide
Lanthipeptides: BQ9856_RS23080_lanthipeptide
2
G H G V-N T I S A E C R W N S L Q A I F T C C
24
G+G V T I S E C N+ Q I F T C C
1
G N G V I K T I S H E C A M N T W Q F I F T C C
24
58.3%
NZ_CP084014.1 and 6 others:
NZ_CP084014.1 Lanthipeptides: LCQ72_RS00100_lanthipeptide NZ_CP084014.1 Lanthipeptides: LCQ72_RS00095_lanthipeptide NZ_CP094679.1 Lanthipeptides: K5I24_RS13105_lanthipeptide NZ_JAQEYW010000015.1 Lanthipeptides: PG422_RS12415_lanthipeptide NZ_JAQEYW010000015.1 Lanthipeptides: PG422_RS12410_lanthipeptide NZ_JAQEYW010000015.1 Lanthipeptides: PG422_RS12405_lanthipeptide
Lanthipeptides: LCQ72_RS00105_lanthipeptide
2
G H G V-N T I S A E C R W N S L Q A I F T C C
24
G+G V T I S E C N+ Q +F T C C
1
G N G V L K T I S H E C N M N T W Q F L F T C C
24
58.3%
NZ_MSRJ01000005.1:
Lanthipeptides: BKH06_RS03755_lanthipeptide
5
V N T I S A E C R W N S L Q A I F T C C
24
V T I S E C N S Q I F T C C
4
V T T I S H E C N M N S W Q F I F T C C
23
56.0%
NZ_FOZB01000002.1:
Lanthipeptides: BM306_RS07850_lanthipeptide
2
G H G V-N T I S A E C R W N S L Q A I F T C C
24
G G V T I S E C N+ I F T C C
1
G D G V F R T I S H E C H M N T W M F I F T C C
24

#### MIBiG 4.0 matches for E9649_RS08770

12.8%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
7
T I S A E C R W N
15
T+S E C+ N
29
T L S K E C Q P N
37
11.8%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
4
G V N T I S A E C R
13
G N +A C
18
G C N M K T A T C H
27

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

E9649_RS08760 - Class II
  Cleavage pHMM score: 5.20
  RODEO score: 0
  Monoisotopic mass: 2776.3 Da
  Molecular weight: 2778.2 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2796.2 Da N = 1
    2814.2 Da N = 2
E9649_RS08765 - Class II
  Cleavage pHMM score: 5.20
  RODEO score: 0
  Monoisotopic mass: 2776.3 Da
  Molecular weight: 2778.2 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2796.2 Da N = 1
    2814.2 Da N = 2
E9649_RS08770 - Class II
  Cleavage pHMM score: 3.80
  RODEO score: 0
  Monoisotopic mass: 2593.2 Da
  Molecular weight: 2594.9 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2613.0 Da N = 1