LOCUS       NZ_LR134483            31244 bp    DNA     circular CON 14-DEC-2024
DEFINITION  Listeria grayi strain NCTC 10812 chromosome 1, complete sequence.
ACCESSION   NZ_LR134483
VERSION     NZ_LR134483.1
KEYWORDS    RefSeq.
SOURCE      Listeria grayi
  ORGANISM  Listeria grayi
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Listeriaceae;
            Listeria.
REFERENCE   1  (bases 1 to 2751104)
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (18-DEC-2018) WTSI, Pathogen Informatics, Wellcome Trust
            Sanger Institute, CB10 1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900638015.1-RS_2024_12_13
            Annotation Date                   :: 12/13/2024 14:24:07
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,747
            CDSs (total)                      :: 2,660
            Genes (coding)                    :: 2,633
            CDSs (with protein)               :: 2,633
            Genes (RNA)                       :: 87
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 27
            CDSs (without protein)            :: 27
            Pseudo Genes (ambiguous residues) :: 0 of 27
            Pseudo Genes (frameshifted)       :: 9 of 27
            Pseudo Genes (incomplete)         :: 16 of 27
            Pseudo Genes (internal stop)      :: 5 of 27
            Pseudo Genes (multiple problems)  :: 3 of 27
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:53:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 340858
            Orig. end                         :: 372102
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LR134483.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..31244
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="2"
                     /rules="cds(LANC_like and DUF4135)"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     cand_cluster    1..31244
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="neighbouring"
                     /product="lanthipeptide-class-ii"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..27762
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27762
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:17762](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..17762
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    312..332
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 24.85"
                     /tool="antismash"
     misc_feature    424..437
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 21.57"
                     /tool="antismash"
     gene            1073..1915
                     /locus_tag="EL241_RS01670"
                     /old_locus_tag="NCTC10812_00343"
     CDS             1073..1915
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007545203.1"
                     /locus_tag="EL241_RS01670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10812_00343"
                     /product="two-component system regulatory protein YycI"
                     /protein_id="WP_170166132.1"
                     /transl_table=11
                     /translation="MDWRKTEIIFIITFLLVDIFLGVVWFNKKLADNTDKLSSSSIQEN
                     LRNDHIKYPADLSEKSASGAIFTAEPYIFQTKELKELKDQSLTIQNQGTILHSQLKKPI
                     QVDPKKDNPDLKQFIENHVYKGKSYAFWKYDEQAHELVYYQVMHKSPILFEKNAYVRFY
                     LNNDNEVTSYEQTLLEKQNDLKEKNDLISASVALESIYQHGKLQQKSEIKAITFGYYTT
                     VKLSTGNFYFPVWCFEIENKNVTEFLLVNAEDNQIINVTDMEQKGLEETKASGMLLPR"
     gene            1988..2818
                     /locus_tag="EL241_RS01675"
                     /old_locus_tag="NCTC10812_00344"
     CDS             1988..2818
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003757364.1"
                     /locus_tag="EL241_RS01675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10812_00344"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_003757364.1"
                     /transl_table=11
                     /translation="MFSETAQTKIQTDQIRFSILASGSSGNATLVETGDQKILVDCGLS
                     GKKIEGLFEQVGRKMSDLDAILVTHEHVDHIKGLGVIARKYKLPVFANQKTWQAMDSMI
                     GEVNSDQKFHFDMETVKSFGSLQVESFGVSHDAIEPMFYIFHSGDKKFVMITDTGYVSD
                     RMKGHIKGADAYLFESNHDIEMLRMGRYPWNVKRRILGDEGHVSNEDAGIAISEVITDK
                     TKRIYLGHLSKDNNMKDLARMSVSQTLAAQDIIVGTQLELFDTDPAVPTDIFTI"
     misc_feature    complement(2894..2911)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: medium, score: 19.05"
                     /tool="antismash"
     gene            2940..4352
                     /locus_tag="EL241_RS01680"
                     /old_locus_tag="NCTC10812_00345"
     CDS             2940..4352
                     /EC_number="3.4.21.-"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003757366.1"
                     /locus_tag="EL241_RS01680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10812_00345"
                     /product="S1C family serine protease"
                     /protein_id="WP_036103576.1"
                     /transl_table=11
                     /translation="MDETNRENFPEKTENDLQVSNTNSPQEIPAETISSTDTFFDEMNN
                     RDPFRTELTQGGNDNTPPPPNNNHNTSNGGNGEPPRKGGKGNFIGYFLTGLIGVIVGAL
                     IIYFIPWNNDNDSLTNNAVNTTTKGQKVENVSVNTTTNITKAVGKVQDAVVSVLNYQSS
                     GDPLDGNTSEKQASSGSGVIYKKANGKAYIVTNNHVVANAEKLEVTFANGKKASAKLLG
                     TDVWNDLAVLEINGKNVSKVAEFGNSDSLKVGEPAIAIGSPLGTEFSGSVTEGIISGLN
                     RAVPVDTNSDGQEDWEADVIQTDAAVNPGNSGGALINIQGQVIGINSMKISMQNVEGIS
                     FSIPINTVEPIIQQLETKGEVVRPSLGVTLRDVETIPSAQQKSVLKLPENINYGAMVQQ
                     VTKSSAAAKAGLKQYDVITELNGKKVTNSISLRKELYSPNLQIGDKIAIKYYRDGKLKS
                     TTLTLVALKEGA"
     gene            4635..5150
                     /locus_tag="EL241_RS01685"
                     /old_locus_tag="NCTC10812_00346"
     CDS             4635..5150
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003757368.1"
                     /locus_tag="EL241_RS01685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10812_00346"
                     /product="type 1 glutamine amidotransferase
                     domain-containing protein"
                     /protein_id="WP_036103578.1"
                     /transl_table=11
                     /translation="MGKKIATVITDLFEDVEYTDPAEAFKKEGHEVTTIEKESGKTVKG
                     KAEQTPVTIDKGIDEVNAKDFDALFIPGGFSPDQLRADERFVKFATEFLQANKPIFAIC
                     HGPQLLIQTGQLKGRTVTGFTSILLDLKNAGANVKDEEAVVDDNIVTSRNPDDIPAFIK
                     ESLKQLEK"
     misc_feature    complement(5239..5254)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: medium, score: 23.92"
                     /tool="antismash"
     misc_feature    5493..5506
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 21.59"
                     /tool="antismash"
     gene            5674..6153
                     /gene="rlmH"
                     /locus_tag="EL241_RS01690"
                     /old_locus_tag="NCTC10812_00347"
     CDS             5674..6153
                     /EC_number="2.1.1.177"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006364 - rRNA processing [Evidence IEA]"
                     /codon_start=1
                     /gene="rlmH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_463824.1"
                     /locus_tag="EL241_RS01690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10812_00347"
                     /product="23S rRNA
                     (pseudouridine(1915)-N(3))-methyltransferase RlmH"
                     /protein_id="WP_003757370.1"
                     /transl_table=11
                     /translation="MNIQIITVGKLKEKYLTQGINEYLKRLQAYAKVQIIELPDEKAPE
                     VLSQAEMEQVKLKEGERILGKISDDAHVVALAILGKQKTSEQFAAGIEKLMTYGKSKIV
                     FVIGGSLGLGDNVLKRADEEMSFGKLTLPHQLMRLVLVEQVYRAFRIMRGEPYHK"
     CDS             6175..6276
                     /gene="allorf_0347033_0347134"
                     /locus_tag="allorf_0347033_0347134"
                     /protein_id="allorf_0347033_0347134"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MGISSFRLYFLRNIFAINCSSYIQVFSYYFVLN"
     CDS_motif       6175..6225
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MGISSFRLYFLRNIFAI"
                     /locus_tag="allorf_0347033_0347134_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       6226..6276
                     /prepeptide="core"
                     /locus_tag="allorf_0347033_0347134_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.00"
                     /molecular_weight="1893.1"
                     /monoisotopic_mass="1891.9"
                     /core_sequence="NCSSYIQVFSYYFVLN"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MGISSFRLYFLRNIFAI"
                     /leader_location="[6174:6225](+)"
                     /alternative_weights="1911.1"
                     /alternative_weights="1929.1"
     misc_feature    6519..6536
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 22.53"
                     /tool="antismash"
     gene            6790..7002
                     /locus_tag="EL241_RS01695"
                     /old_locus_tag="NCTC10812_00349"
     CDS             6790..7002
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EL241_RS01695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NCTC10812_00349"
                     /product="hypothetical protein"
                     /protein_id="WP_036103580.1"
                     /transl_table=11
                     /translation="MNLAQKLLWCQSQMMHYEEIPIEVKTISYEEGLLEKSELPIELEQ
                     FLSRHCSENEWNIEIFQWNRCQTLI"
     gene            7402..7695
                     /locus_tag="EL241_RS01700"
                     /old_locus_tag="NCTC10812_00350"
     CDS             7402..7695
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020345.5"
                     /locus_tag="EL241_RS01700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10812_00350"
                     /product="Mor transcription activator family protein"
                     /protein_id="WP_052009049.1"
                     /transl_table=11
                     /translation="MFHEPKVHEDCLAELYKELSELIGLESMLKLYVVLKGQQINFPTR
                     LYAGEKVRAKIYQTYDGESSHKLAREYGYSSRWMQQIVKEYREEKENEKMGH"
     gene            7676..7954
                     /locus_tag="EL241_RS01705"
                     /old_locus_tag="NCTC10812_00351"
     CDS             7676..7954
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EL241_RS01705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NCTC10812_00351"
                     /product="hypothetical protein"
                     /protein_id="WP_036103581.1"
                     /transl_table=11
                     /translation="MKKWGIDSLMIVSFFLLPFYQVTGTVGIITHRQSYAGYSLLTDPI
                     AWLFLFAPIGQQESWLNLESHLHIGGWLYLLLLIIEISQEILRKRSI"
     gene            7958..8506
                     /locus_tag="EL241_RS01710"
                     /old_locus_tag="NCTC10812_00352"
     CDS             7958..8506
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EL241_RS01710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NCTC10812_00352"
                     /product="hypothetical protein"
                     /protein_id="WP_036103582.1"
                     /transl_table=11
                     /translation="MDREKVWLGVQKYGITIGAAVSILSLFLTMFISGDTVRDQLTQRL
                     GGSSAHTLFSGMEVLFGTAYSEGVTLGYLLVAFPVLLLASVFVVSLKKYRSMIQITTPI
                     LSILVLFIVRSQMKAALSFTVNHGANEYYVKGGIGFWLVLLIDLVMIGLWIIQKYQLKI
                     TKDNLRSFIDKKDWNELKK"
     gene            8782..9270
                     /locus_tag="EL241_RS01715"
                     /old_locus_tag="NCTC10812_00353"
     CDS             8782..9270
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EL241_RS01715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NCTC10812_00353"
                     /product="hypothetical protein"
                     /protein_id="WP_036103583.1"
                     /transl_table=11
                     /translation="MNGDIGDRNLFQELEETIYRNIINILKHGSSDIEMDFKNLLYEES
                     QSVQELLGIACFMFFAKIYNDFIGSKNVENVRQIDNLRQLKKMTKYLVSKYENSTFFDE
                     KASNIQILVYYLFYKGYEEKYLYTKDVKSKKDITDMMIDEGIIDDNVNINTIYKRIFL"
     misc_feature    complement(9410..9425)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.97"
                     /tool="antismash"
     gene            9580..9759
                     /locus_tag="EL241_RS01720"
                     /old_locus_tag="NCTC10812_00354"
     CDS             9580..9759
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_ha"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF000539.0"
                     /locus_tag="EL241_RS01720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10812_00354"
                     /product="plantaricin C family lantibiotic"
                     /protein_id="WP_036103586.1"
                     /sec_met_domain="mature_ha (E-value: 7.2e-10, bitscore:
                     35.7, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKKEWEKTAQIVQEGFLQEVEEQEIGEESGGAWWNVSKNLGNKG
                     RICTLTKECQSMCN"
     CDS_motif       9580..9678
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MEKKEWEKTAQIVQEGFLQEVEEQEIGEESGGA"
                     /locus_tag="EL241_RS01720_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9679..9759
                     /prepeptide="core"
                     /locus_tag="EL241_RS01720_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.70"
                     /molecular_weight="2942.4"
                     /monoisotopic_mass="2940.4"
                     /core_sequence="WWNVSKNLGNKGRICTLTKECQSMCN"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEKKEWEKTAQIVQEGFLQEVEEQEIGEESGGA"
                     /leader_location="[9579:9678](+)"
                     /alternative_weights="2960.4"
     gene            9777..9968
                     /locus_tag="EL241_RS01725"
                     /old_locus_tag="NCTC10812_00355"
     CDS             9777..9968
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_ha"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF000539.0"
                     /locus_tag="EL241_RS01725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10812_00355"
                     /product="plantaricin C family lantibiotic"
                     /protein_id="WP_036103587.1"
                     /sec_met_domain="mature_ha (E-value: 9.1e-11, bitscore:
                     38.5, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKKEYGLQRMSQLDQRDFLKEIEEHEKQNQVSGGWGWKDLSKSL
                     GNKGYVCTLTKECQKLCR"
     CDS_motif       9777..9881
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MTKKEYGLQRMSQLDQRDFLKEIEEHEKQNQVSGG"
                     /locus_tag="EL241_RS01725_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9882..9968
                     /prepeptide="core"
                     /locus_tag="EL241_RS01725_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.40"
                     /molecular_weight="3173.7"
                     /monoisotopic_mass="3171.6"
                     /core_sequence="WGWKDLSKSLGNKGYVCTLTKECQKLCR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTKKEYGLQRMSQLDQRDFLKEIEEHEKQNQVSGG"
                     /leader_location="[9776:9881](+)"
                     /alternative_weights="3191.7"
     gene            10001..13051
                     /locus_tag="EL241_RS01730"
                     /old_locus_tag="NCTC10812_00356"
     CDS             10001..13051
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="EL241_RS01730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10812_00356"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_036103589.1"
                     /sec_met_domain="DUF4135 (E-value: 8.3e-88, bitscore:
                     292.4, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 6.8e-67, bitscore:
                     223.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTALKPETAIKQWLPFFPEFKKAEWKLTALLDQSNILKEEPVRTC
                     DLEKMISGWSGLEANRYNKMVCKDVLFPNAFYPIIHRYYRDIDRFVSEEPFILDKESVK
                     QAIFSGLMDKLSNLGNRVLVKDLTEQKQQGYLEGHSPEARFSYYANVLLMDKSYLLRFY
                     QKYDALLALLVQTVVNQLAFFKEVILQTKHRCLDICSLVTKPVIGIVGFGGDLGDSHNN
                     GKSVLVIHFNDGQKVIYKPRSLSLEVTFNKLLQQINTLDTGLAPFKTVKSVDNGDYGWM
                     EYIEHRPCEHKEEVAFFYRNIGQLICLLYFLNGKDFHHENIIAAGKFPTLIDLESLFHN
                     DDGEETVAESTIYRSFYRRLNQSVQGIGILPQCLKNNSYIDFISADVGGVSAEKEQLSP
                     FKSNVIFNRYRDDIYIGKDYGLISVQQNIPIYKGDSVSASDYEGEIRAGFSQMYTWVLG
                     NKAWFYEQVNTIFRGTMNRYIIKPTFLYSQLLALSFHPHVLTSKLNRKVLLHRIGMNQT
                     DRKKALFRAELSSLEKGDIPYFLTKITDTHLYDQAGLLAEDYFSQTPLASSLVKIADSS
                     EADRAFQLYIIKQIFAAKCADQTKNITDIAFKQEADLPLKKAQWLELAKAMGDEIIANA
                     VEMESQGERIVTWIGINFEGQQDQYWELDFIGNNLYLGNAGIALFLGYLGDVTGCERYT
                     KFAKAAVRAVQEELTSITGEEAELIGAFNGVSSYLYAIGKLNELLVGEYTNYIEQSLAV
                     VHKLIKKDTNFDIISGSAGCMLVLINIHNSFQAQPDIQAKILHVIEECYQHICIGAKHM
                     DSGIHWRQKELDPLVGFAHGNAGIIYSLTKYYEMTGQENCLSLIKQALNYERQFYDAEK
                     KGWRFSEQQSDISLGWCNGTPGILASRVALLKSGFRDKRLEEEITIALQEMQINGFGNN
                     PSLCHGDFGNLEITAAVAQDLQDDNLLNSCFATVQHLYDSYLKRNWQAGLFKGTVSYNL
                     MVGLAGCGYALLQAYKNYSLPKILLLD"
     cand_cluster    10530..31244
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    10530..31244
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[20529:21244](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      20530..21244
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="2"
     gene            13077..13946
                     /locus_tag="EL241_RS01735"
                     /old_locus_tag="NCTC10812_00357"
     CDS             13077..13946
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.5"
                     /locus_tag="EL241_RS01735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10812_00357"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_232020858.1"
                     /transl_table=11
                     /translation="MMTFNNVSKKYKEKSVLKDICFTVKSREIIGLVGANGAGKTTLMR
                     ILVGLTKQYEGEIHSEFLKPQIGCVIESPNFYPYLSGYQNLLHFSKYTTSDKSEVIELL
                     DMLGLMDAAHKKVKTYSLGMRQRLGIAQALLGQPDILVLDEPTNGLDPQGVQSMRQYLK
                     RIVKTRNVGILLSSHILSEIEKICDRVMLLKDGILTENIRTLVSEQAHNVAYQFKTPEP
                     TELTNFLQRKHFKVKRFGQVVEVQLPKEKIFSTIRAIIQENLYFESVTAKEADLEEQFM
                     QIVGGDKS"
     gene            13943..14668
                     /locus_tag="EL241_RS01740"
                     /old_locus_tag="NCTC10812_00358"
     CDS             13943..14668
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024091.5"
                     /locus_tag="EL241_RS01740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10812_00358"
                     /product="ABC transporter permease subunit"
                     /protein_id="WP_036103592.1"
                     /transl_table=11
                     /translation="MMTIVRLSLLEVKKIGSRPYSYLVLLVATFASIGMGVEVLSSDTF
                     SMTHIFLFFAMIAEWIIIYYGAKSLGEEFSVKTSTIIFTKNVSRKIILLSKLTSLALIG
                     LMMGIISSSIAVIFQYLLTGNLTGEFLIKEALFNTIAYILFTMLVGSFGILVASLTMNL
                     TTALLISIVAFQFLPALLEMTVEKFSFLKGGMEYIPFHSAIKFLELHQFGTATLVGIIG
                     GIILFTVCSVILIDNKDLV"
     gene            14704..14874
                     /locus_tag="EL241_RS13590"
                     /old_locus_tag="NCTC10812_00359"
     CDS             14704..14874
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038161.1"
                     /locus_tag="EL241_RS13590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10812_00359"
                     /product="class II lanthipeptide, LchA2/BrtA2 family"
                     /protein_id="WP_170166133.1"
                     /transl_table=11
                     /translation="MTNQKKEVMNEKEQKLEAELRELSSHEDENGGFPWTVTVPLSIAL
                     CPTAKCTSKCR"
     CDS_motif       14704..14799
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MTNQKKEVMNEKEQKLEAELRELSSHEDENGG"
                     /locus_tag="EL241_RS13590_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       14800..14874
                     /prepeptide="core"
                     /locus_tag="EL241_RS13590_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.70"
                     /molecular_weight="2515.0"
                     /monoisotopic_mass="2513.4"
                     /core_sequence="FPWTVTVPLSIALCPTAKCTSKCR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTNQKKEVMNEKEQKLEAELRELSSHEDENGG"
                     /leader_location="[14703:14799](+)"
                     /alternative_weights="2533.1"
                     /alternative_weights="2551.1"
                     /alternative_weights="2569.1"
     misc_feature    14739..14752
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.84"
                     /tool="antismash"
     gene            15042..17762
                     /locus_tag="EL241_RS01745"
                     /old_locus_tag="NCTC10812_00360"
     CDS             15042..17762
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="EL241_RS01745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10812_00360"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_126320294.1"
                     /sec_met_domain="DUF4135 (E-value: 1.7e-83, bitscore:
                     278.2, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.1e-46, bitscore:
                     155.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQWKDDQTGVFDNFYKADLNFFQIQAHKIMNQLDTKGLVNVEQVV
                     QALCLELKQRLMSYCSGVLLTNFQKWKMTEVSNNENYAIYNESLLNEQVRTKLLTAYPV
                     MNKLIARTIRQQLEQLYEIISRFLHDREALQVQFKVSLQCLEKVEHLNSDPHKDGRNVV
                     LLTFTNNKKIVYKPRSLAGETTFNRFLEYLNTAGALRYALKNTKILDRAAYGWQEFVMQ
                     KPCNTVSEIKRYFYRVGAYSALFQLLQTSDLHYENIIAAGEYPLFIDLETLVSVKAKKK
                     AQETVLDLFYNEVNGSIIGSLLFPQQLIGSQKTADLSGLTGGSLKIEKVKIIAKGTTDI
                     CEKTQVTQLNCVSNQVTLGKERIDPNEYFTDILAGVSDCFKILYEQKDFFVNEIAAGKL
                     VSGTYRQVLRPTHVYAKYLDSVYRPEYLENTQKTKQLLNIITETAAHKKRTQIELSEML
                     NNDIPHFVCASNSTTLQASNQQTVENYFETTPQQLVENKFKQLTKQEITKQKYYLRLAF
                     NLYAQNKQLANEADLLADFAPDGDFNDKLLDLFETTAIWDCKKEKCTWLLIDNDGETYA
                     LSPLIPSFYLNAGIIWYLAIAGEQRQQMAYTKMAKGAIKGITELPKSFMGETPSAFAGY
                     YSLIYLYYNLSVLWKDKTLLHQSYQLIKSISVDQNTSLEQIDYVNGISGMIHLLTRIYE
                     KDKQDFILETACMLGEKLDASLKSAEAKTGLAHGLSGYALALASLWQHTNNKTYKERTL
                     KLLEAEDQLFDSISGNWIDVRTSQSKLNYWCYGAWGILLARKQITIYLNDQTISQSSIC
                     IRALKNAWEMKETSLNNSLCHGNAGNGIIRQLLADIAAENGLTTMQNVLNFTEKPYQQL
                     PTLQFMLGLTGVGYALLRQEEPSLPAMLDLSLLSS"
     gene            17776..19929
                     /locus_tag="EL241_RS01750"
                     /old_locus_tag="NCTC10812_00361"
     CDS             17776..19929
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.5"
                     /locus_tag="EL241_RS01750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10812_00361"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_126320295.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 6e-38, bitscore:
                     127.0, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKRRVPYVEQVQATECGLCAVAMILRYHKSYETLHDLRTSVDTG
                     RDGSSLRQLKLLLEEHHFKVHIYEASSNGLNQIALPAIIFWEKEHFVVLESIQKQAYTI
                     IDPAVGRRVIKTDQFQAAFSNFVLTAKPKPSFEPKARSENPWKTIISDSLINKKLVGQV
                     IVFALLSYLVTLGLPIIVQHIIDTLATFNSQLIIQLVCLMMVLFGIYGFALYMRGQKLI
                     ALQQVIDRSLMGGTFSHLLKLPYNFYEVRTSGDLLFRMNTLTVIKELLSEDIITGIIDL
                     GGVLFVAAYMFYLSPVLAGVALLVFILNGIFIIMTRPRVLELNQSEIAESSKLQTIQVE
                     SIYSILGVKLAALEEHVRRNWYAQFKRVLGSYQKRATFSNLFTTVTSLVQVGAPFLVLI
                     VGIIQYQQAALTLGEVIAFNSISAIFFSLSTAIFNTYNKYLVASSFLERLQDIREAKAE
                     VSNSTGVQPQLEGDVTLRNVSFSYSKNSQRVLKDINLKIKHGEKIAIVGSSGSGKSTLA
                     KLALGLYTPTRGEIQYDGISMLTLNKQNLRKQMGIVPQDINLFNKSILENIRMNQENIS
                     LRDVQTAAKLAQIHEEIEAMPMGYHTLVSEMGLNLSGGQRQRIALARALINKPRVIVLD
                     EATSSLDAVNEQRVAQYLSNIGATRIIIAHRLSTIIDADKIYVMREGRIVEEGKHEELF
                     QRKGYYYQLYAAQLSHQKSMLTA"
     gene            19959..20420
                     /locus_tag="EL241_RS01755"
                     /old_locus_tag="NCTC10812_00362"
     CDS             19959..20420
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EL241_RS01755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NCTC10812_00362"
                     /product="hypothetical protein"
                     /protein_id="WP_036103607.1"
                     /transl_table=11
                     /translation="MRRSILGKEVATISFTTLEMLEEANQAVVPILEIFELLKQYAPKN
                     SMKKNLDFRIVLLIDGCLYIKRINEDSIVVFQNDLLVEFNKDKQYLFLLEGGLEQSLLQ
                     LMLHIKRSFHVVEFHSISLQAWNVTMILQVELGIQGNNVKEEKTNTSDL"
     gene            20530..21153
                     /locus_tag="EL241_RS01760"
                     /old_locus_tag="NCTC10812_00363"
     CDS             20530..21153
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009372 - quorum sensing [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016526.5"
                     /locus_tag="EL241_RS01760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10812_00363"
                     /product="accessory gene regulator B family protein"
                     /protein_id="WP_036103610.1"
                     /sec_met_domain="AgrB (E-value: 1e-27, bitscore: 94.0,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDIKMTGWNLWGIEHRLAKRVLERLTAGEAMSEQKFLKCKLGIEA
                     LINNMFKLSIVYAVAFVMNTFLATLFVHLGFLAIRTFAYGAHAKSSVGCIGISTLALVG
                     LPLLIQKTFLFPRVVLLLAALLIAYGLWEYAPGTTAKNKITSEIKKKRLKKRALFSCFL
                     TIVISSLLPLLEANLLLIGNLLAVCCIIPVFIKKGGNQDEKISD"
     gene            21134..21244
                     /locus_tag="EL241_RS01765"
                     /old_locus_tag="NCTC10812_00364"
     CDS             21134..21244
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR04223.1"
                     /locus_tag="EL241_RS01765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10812_00364"
                     /product="cyclic lactone autoinducer peptide"
                     /protein_id="WP_126320296.1"
                     /sec_met_domain="TIGR04223 (E-value: 5.7e-05, bitscore:
                     20.5, seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLVINLFEMFGSLNVRQCCFLLSDEIEIPDELAE"
     CDS_motif       21134..21175
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKKLVINLFEMFGS"
                     /locus_tag="EL241_RS01765_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       21176..21244
                     /prepeptide="core"
                     /locus_tag="EL241_RS01765_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.80"
                     /molecular_weight="2531.9"
                     /monoisotopic_mass="2530.2"
                     /core_sequence="LNVRQCCFLLSDEIEIPDELAE"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKKLVINLFEMFGS"
                     /leader_location="[21133:21175](+)"
     gene            21326..22627
                     /locus_tag="EL241_RS01770"
                     /old_locus_tag="NCTC10812_00365"
     CDS             21326..22627
                     /EC_number="2.7.13.3"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025854.5"
                     /locus_tag="EL241_RS01770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10812_00365"
                     /product="sensor histidine kinase"
                     /protein_id="WP_052009052.1"
                     /transl_table=11
                     /translation="MEVAIGIILQTLLLHLNGKILVHNRKVTISEFVFLTVVAVIMVLM
                     YNYLNFFTSIVMILNILIINYLKYHKLVLAVGVTSYATIILVLSDHLATIMEVYVLQIN
                     QTHINYTYVFAHLGIQIILSVLISYWVANMIKRVEKKLGLDIVHNIFVAVLGLATMIVY
                     YTSIYLGFFLGNAFPLIQLNLMFFIGYLVITLFIFFFYMHALKNKYEVEQKEIEYESMN
                     RYTEAMEKQYHEVRKFRHDYKNILSSIDDYLLENDYEGLKIYFLHKIKPSSEMIDRNNF
                     KLNDLRNIKIRELKSILSFKLISAQEAGIDIVIEVTGQIKVVPTDTIILVRLIGIILDN
                     AVEEVQFLGKGQIAVSLFEDFHSVQIIVQNTCRENIPKIHQLKKEGFSTKGENRGLGLS
                     NMSEMINQTANLLLETTTEPRLFIQRLIIQKERR"
     gene            22632..23369
                     /locus_tag="EL241_RS01775"
                     /old_locus_tag="NCTC10812_00366"
     CDS             22632..23369
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001974694.1"
                     /locus_tag="EL241_RS01775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10812_00366"
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_036103612.1"
                     /transl_table=11
                     /translation="MLSIFICEDEDKQREKVETCIKNYILMEDLDMEVVLSTANPTEVL
                     DYVESHDHTVGLYFLDIDLQHPMNGLTLAAEIRKIDDLGKIVFVTTHGEMSYLTFTYKI
                     EAMDYIIKDYPEEIQQKIQACLRVAYERYRNDRIGKKQLFQVKLGDNVRSIHIDDIIFF
                     EASPAAHRVILHLENSELEFYGSIKSLESISTDFYRCHKSYLINKNHIMEINKNERLVI
                     MSNEQACLVSVRALSGLVKIHKR"
     gene            complement(23711..24574)
                     /locus_tag="EL241_RS01780"
                     /old_locus_tag="NCTC10812_00367"
     CDS             complement(23711..24574)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_463825.1"
                     /locus_tag="EL241_RS01780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10812_00367"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_036103615.1"
                     /transl_table=11
                     /translation="MDIENMKAFNKVAELKSISAAASELHHLQSNMSNKIKNIEKQFQT
                     QLFFRHSSGVELTQNGEKLYHQFQKMILLWEETTAIITNKEETILLGIPQTSFPTQFND
                     IIKDFYTQFPNKKLSIVSGTTNELIHKVVNRELTIAYVTELENEQLLQDKQVISEMLSQ
                     DKLVFAGKTKGISLQKILTEERLYVFSKQCYSYRALASLMKDLNVETASISEINIAETL
                     FEICKNELGIGIIPESIALKYHFLTYETLPDEYAKLRKTLIYHTDHPISSAEKWLIEKS
                     KPAFQR"
     gene            24714..25451
                     /locus_tag="EL241_RS01785"
                     /old_locus_tag="NCTC10812_00368"
     CDS             24714..25451
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00881"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_463826.1"
                     /locus_tag="EL241_RS01785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10812_00368"
                     /product="NADPH-dependent oxidoreductase"
                     /protein_id="WP_036103618.1"
                     /sec_met_domain="PF00881 (E-value: 2e-18, bitscore: 64.4,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTIQQLVKHVSVREFKKERLSDEIKQTLVTAARSGATSHFVQA
                     FSILEITDQSLRAKLAEITDSASYVKQTGTFYVFVGDLYRQSQLLLEDNQSLAGLRNME
                     SLLVAVVDATIAAQNMVVAAESLDLGICYIGGIRNDIAKVAELLNLPPFTIPVFGLTVG
                     VPAHKNQVKTRLLPENQVSENQYPHDRFADLKAYEALTREYYALREKNGQQTSWPDKNI
                     EFFKAIRRPEIAAFLKKQGFTLD"
     misc_feature    25510..25527
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: medium, score: 19.32"
                     /tool="antismash"
     gene            25641..27134
                     /locus_tag="EL241_RS01790"
                     /old_locus_tag="NCTC10812_00369"
     CDS             25641..27134
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017548197.1"
                     /locus_tag="EL241_RS01790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10812_00369"
                     /product="PRD domain-containing protein"
                     /protein_id="WP_126320297.1"
                     /transl_table=11
                     /translation="MAKKTNREQHLLLTLFETQGYMTAEELANILQISAKTIYRLIKRI
                     NDAEAKDPLIVSEKGRGYKLNYEKYLSQKKWQQSKEDIYSPSERRNRVMEELLLISPRA
                     KNIHNLFEDYYVGDSAIFNDEQEIARQIKEYELTLERKKRTLAIIGDERNIRRAIVDLV
                     ATFSTIDLDELESIKVSNLNNYDVLFVIRQLREIESSLAITIPYPYSVNIFSHLYILIS
                     RFRKVGALQIDKERPLTEKELAEFHSDPYLHQIAKDVIRNVENYLHQKLSELEVYYLYQ
                     YLLSSRMQGKSHGNAHNFSPKVMQITHMYLNEMTARLNNDMNNETNFLDLANHIKPMIN
                     RLENKIRIKNGLIEQIMITYPEIFEQVTEVSEKISKNYDLPPIHRDENGFITLYFARIL
                     ETNTSPIKTIIMCTTGIGTSELLLAKVEKRFPELEVIDVAASRYSKENLRKHPEAELIL
                     TTVQLPQDLPIQSLVVSAMLTADDQNRIQRKIEELQHGK"
     gene            27124..27558
                     /locus_tag="EL241_RS01795"
                     /old_locus_tag="NCTC10812_00370"
     CDS             27124..27558
                     /GO_component="GO:1902495 - transmembrane transporter
                     complex [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012579.5"
                     /locus_tag="EL241_RS01795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10812_00370"
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="WP_170166134.1"
                     /transl_table=11
                     /translation="MENKKWLKAYFNQPLQTKKEMYEFIANYGENDQLSHENINRALRE
                     RELASNLQIAPHVVLPHFESLALTESSVLIIHLQEEISCWDQTAADIKLVIAILLKTNE
                     SLEIKKEIALFTRSLADETFIQNLLCAEKEAIFMDYLKKI"
     gene            27571..27897
                     /locus_tag="EL241_RS01800"
                     /old_locus_tag="NCTC10812_00371"
     CDS             27571..27897
                     /EC_number="2.7.1.202"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_function="GO:0022877 -
                     protein-N(PI)-phosphohistidine-fructose phosphotransferase
                     system transporter activity [Evidence IEA]"
                     /GO_function="GO:0090563 - protein-phosphocysteine-sugar
                     phosphotransferase activity [Evidence IEA]"
                     /GO_function="GO:0090582 -
                     protein-phosphocysteine-D-fructose-phosphotransferase
                     system transporter activity [Evidence IEA]"
                     /GO_process="GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018664305.1"
                     /locus_tag="EL241_RS01800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10812_00371"
                     /product="PTS fructose transporter subunit IIB"
                     /protein_id="WP_036103622.1"
                     /transl_table=11
                     /translation="MKIVGVAACTVGIAHTYIAQEKLESAAQEAGHDIHMETQGTIGIE
                     NELSQEQIDAADIVILAIDVKIAGRERFENKRIIQVPTDVAIKSPKKLLEKAKEVVSQG
                     NASN"
     gene            27909..28358
                     /locus_tag="EL241_RS01805"
                     /old_locus_tag="NCTC10812_00372"
     CDS             27909..28358
                     /GO_component="GO:1902495 - transmembrane transporter
                     complex [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017548194.1"
                     /locus_tag="EL241_RS01805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10812_00372"
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="WP_126320299.1"
                     /transl_table=11
                     /translation="MEVKDIVDLKTVTTNLKATTKESALQELSELLKDNNYISDIDGFM
                     KDVYAREAEGQTGIGNFVAIPHGKSEFVSKNGVAIGITENEIPWESLDDHGAKVVILFA
                     VGNDMEAAKEHLKLLSLFARKLGKDKVVAKLLNSESAEDVVEAFA"
     misc_feature    complement(28369..28383)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 22.16"
                     /tool="antismash"
     gene            28406..29506
                     /locus_tag="EL241_RS01810"
                     /old_locus_tag="NCTC10812_00373"
     CDS             28406..29506
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017548193.1"
                     /locus_tag="EL241_RS01810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10812_00373"
                     /product="PTS fructose transporter subunit IIC"
                     /protein_id="WP_036103623.1"
                     /transl_table=11
                     /translation="MKALRKLDLKGHLLTAISYLIPVVCGAGFLIAIGMAFGGSSQDAL
                     VQGKFTIWDALATMGGKGLGLLPLVISTGIAYSIAAKPGIAPGFIIGLTANAIGAGFIG
                     GILGGYLAGYLVLAVLKYVKVPSWAKGLLPTLIIPFLTSIVGGLIMVYIIGVPIAWFTS
                     LLTGLLNGLGSSSLSVFGAAVGILSGVDYGGPINKTVFAFVLTMQAEGINGPITALQLV
                     NTATPIGFGLAYFVAKLFRKNIYSSVEIETLKSAVPMGVINIVEGVIPIVMNDIVRCVV
                     ATAIGGAAGGAVSMLLGADATVPFGGVLMLPTMSRPWAGVIALLVNIIVTAVALALIKK
                     NVSKQELDEKAAVEEEDIDLDDIQIF"
     gene            29526..30221
                     /gene="alsE"
                     /locus_tag="EL241_RS01815"
                     /old_locus_tag="NCTC10812_00374"
     CDS             29526..30221
                     /codon_start=1
                     /gene="alsE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010346156.1"
                     /locus_tag="EL241_RS01815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10812_00374"
                     /product="D-allulose 6-phosphate 3-epimerase"
                     /protein_id="WP_324603452.1"
                     /transl_table=11
                     /translation="MMNKVRFSPSLMTMDLDKFSEQITFLNNYADSYHIDIMDGHYVPN
                     ITLSPWFIEEVRKISDLPVSAHLMVTDPSFWVEQLIALKCEWICIHAEVLDGLAFRLID
                     QIHDAGLKAGIVLNPETPIDTIFPYIELVDKITIMTVDPGFAGQRFIKSTLNKIVDLRN
                     LRDAKGYRYVIEMDGSSNRKSFKDIDIAGPDIYIVGRSGLFGLTDDIEESWNIMLKDYE
                     EATGKKVEV"
     misc_feature    29552..29566
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.58"
                     /tool="antismash"
     misc_feature    31169..31178
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 15.96"
                     /tool="antismash"
ORIGIN
        1 cggggaacta cttttgggtt ctcggaagtg ctcgtttccg aaaagaaaaa aacagaaaca
       61 tacgagagca tcatccatca aaatgataca tttgaattag tctatccaac taccataccg
      121 ttcaccatct tttcgcaggt tttccatgtt tctggtaaaa atctgcaatc agattctttc
      181 aaccgcatca tttttgataa aaatgccagc gatacaggtc tgcatacggt ttattttgca
      241 aatgaccaaa accacacgat ctaccagagc agtctgcagg agaaggatat gaacgaagta
      301 gcatcgatcg tgaataaagc aaaggataca ttcatcgaaa atgatgtggt tatcgatcaa
      361 aacaggcgac tatatttaag cagttcgccg ttaaacatcg attctcggaa atttatcatc
      421 agctcgatca agatcaacct attcatatcc gcgcttttcc aagattcgga ttccatcaaa
      481 aatgaaggta ataattacac aaatggttcc agtatcattc aagtcaatcc tgaatacaaa
      541 acattagaat atgtaaatca ggcacaagaa cgtaatcgtc cggaactgct tcccaaacaa
      601 aaacaagcca tgatgatcca agacagtttt aactttgtca atgaacacgc aggctggact
      661 ggcaatttta catttgctgg ctatgatgtc aacagtggga gtacgaactt tatgcttgat
      721 gtacacaata tgatggtgtt caatcctgat aaaatgacga cgatttctgt cgcacaaggt
      781 caggaaagtg ttttccgcta tacccggccg tattacatgt tcgaatcaga gatctattcg
      841 gcgaagcgga aagtaaagtt agagtcatct tatagtgcct atcaaaaact gatcaagagc
      901 aaagcagttg atccgcaaaa cattgatgca atggcgcctg gctacgaaat gaaacgctcc
      961 aattgggaaa atacctcttc gcttaatcgc gttgtcgaat tggaaccagt atggatgttc
     1021 caatacaaag gaacttggtt ttctgtaaat gacacagagg ggggtaatta atatggattg
     1081 gcgtaagacg gaaatcatct ttatcattac tttcctgctt gtcgacatct ttctcggagt
     1141 tgtttggttc aataaaaaac tagccgacaa tactgacaaa ctgagttctt ccagcattca
     1201 agaaaacctg aggaacgatc atatcaaata tcctgccgat ctttcggaaa agtcggcgtc
     1261 aggagcgatt tttaccgcag aaccatatat ttttcaaaca aaagagttga aagagctcaa
     1321 agatcaatca cttacgatcc aaaatcaagg aacgatcttg cattcgcaat tgaaaaagcc
     1381 gatccaagta gatcccaaaa aagacaaccc cgatctcaaa cagtttattg aaaatcacgt
     1441 ttataaagga aaatcctatg ctttttggaa gtatgatgaa caggcacatg agctggtcta
     1501 ttatcaagtc atgcacaaaa gtccgatctt atttgagaaa aatgcgtatg tccgctttta
     1561 tctcaacaac gacaatgaag ttacttctta tgagcagaca ttgctggaaa aacaaaatga
     1621 tctgaaagaa aagaatgacc tgatctctgc ttccgttgca cttgaatcga tctatcagca
     1681 cgggaaactg cagcagaaaa gcgagatcaa agcaatcact tttggctact atacgaccgt
     1741 aaaactctcc accgggaatt tttatttccc agtttggtgt tttgagatcg agaacaaaaa
     1801 tgtcacagag ttcttattag ttaatgctga ggacaatcag atcatcaatg ttacagatat
     1861 ggaacaaaaa ggattagaag aaacaaaagc aagcggtatg ttgctcccta gatagttagc
     1921 aagagatgct tttttccgta aatagcgtta gaatagaagc agcagaggtt gcaaggggga
     1981 aaaaataatg ttttcagaaa cagcccaaac aaaaatacag acagatcaga tccgctttag
     2041 tattcttgca agcggaagct caggaaatgc aactttagtc gaaacaggcg accaaaagat
     2101 attggtggac tgcgggctaa gcggtaagaa aatcgaagga ttatttgaac aagtgggcag
     2161 aaaaatgtcg gacttggatg cgatcttggt tacccatgag cacgtggatc atatcaaagg
     2221 cctcggcgtc attgctcgta aatataaact gcctgttttt gcgaatcaaa aaacatggca
     2281 agcaatggat tctatgatcg gtgaagtaaa ctcagatcaa aaattccatt ttgatatgga
     2341 aacagtaaaa tcattcggca gtctgcaggt ggaaagcttc ggtgtttccc atgatgcgat
     2401 cgaaccgatg ttttacattt ttcacagtgg cgacaaaaaa tttgtcatga tcaccgatac
     2461 aggatatgta agcgatcgga tgaaaggcca tatcaaaggc gcggatgctt atttatttga
     2521 aagcaaccac gatattgaga tgctacggat gggccgctac ccttggaacg tgaaacgacg
     2581 tattcttgga gatgaaggtc acgtaagcaa tgaagatgcc ggcattgcga tcagtgaagt
     2641 gatcactgat aagacgaaac gcatttactt aggacattta agtaaagata acaatatgaa
     2701 agatctagcg agaatgagcg tgagtcaaac gttggcagcg caggatatca tcgttggcac
     2761 gcagttggaa ttgtttgata ccgatccggc tgttccaacg gacatattta ctatataaga
     2821 aattgcagag ataacttttc tctgctttct ttatattttt aaaatttttt catcattttt
     2881 tcatatttgt ttattaatat aaagataaca acgatattta ttcaggaagg agcaataaaa
     2941 tggacgaaac aaatagagaa aatttccctg aaaagacgga aaatgatctg caagtcagta
     3001 acaccaattc tccgcaagag attccagctg aaacgatcag ttcgaccgat actttttttg
     3061 acgaaatgaa taatcgggat cctttccgca ccgagctcac ccaaggagga aatgacaaca
     3121 cacctccacc acccaataac aatcacaata ctagtaacgg tggaaatggc gaaccccctc
     3181 gcaaaggcgg gaaaggcaat tttattggct attttttgac cggattgatc ggtgtcattg
     3241 tgggcgctct tatcatttat tttattccat ggaataatga caacgattca ctcacaaata
     3301 atgcagtcaa tacaactaca aaaggccaaa aagtagaaaa tgtttccgtt aataccacga
     3361 ccaacattac aaaagcagtc ggcaaagtcc aagatgccgt ggtcagcgta ctcaactatc
     3421 aatcttccgg agatccactg gacggaaaca cttccgaaaa acaagcttct tcaggttccg
     3481 gtgttattta taaaaaagca aacggcaaag cttatatcgt taccaataat cacgttgtcg
     3541 cgaacgcaga gaaattggaa gtaacttttg caaacggtaa aaaagcttct gcaaaactgc
     3601 tgggcactga tgtatggaat gacttggccg ttttagagat caatggtaaa aatgtttcta
     3661 aagtagcaga attcggcaat tccgattccc taaaagtcgg cgaaccagca attgcgatcg
     3721 ggagtccgct tggaacagaa ttttccggtt ccgtaacaga aggaatcatt tccggcttaa
     3781 atcgtgccgt accagtagac actaatagcg acggccaaga agattgggaa gctgacgtta
     3841 tccaaacaga cgcagcagtc aacccaggta acagcggcgg tgcattgatc aatatccaag
     3901 gacaagtcat cggcatcaac tcgatgaaaa tctcgatgca gaacgtagaa ggaatcagct
     3961 tctccattcc gatcaatact gtagaaccaa tcattcaaca actagaaaca aaaggcgaag
     4021 tagtgagacc atccctaggc gtgacccttc gcgacgttga aacgatccca agcgcacaac
     4081 aaaaaagcgt cttgaaactt ccagaaaaca tcaactacgg cgccatggtc caacaagtca
     4141 ccaaatcatc agccgcagct aaagcaggct tgaaacaata tgacgttatt acagaattaa
     4201 atggcaaaaa agttactaac tccatttccc tacgtaaaga attatattca ccaaaccttc
     4261 aaatcggcga caagatcgcg atcaaatatt accgtgacgg taaattgaag agtactactc
     4321 tgacattggt tgctttgaaa gaaggcgcgt aactcagaac ccctacctaa ggggttctca
     4381 gcttggcgaa aaacgctcat cttcgtcgtt aaagcctgcg ttccgatgct cacgtacaca
     4441 agtacgctcc gcttcggtac tcagctttgc ctagaatcta atcatttttc accaagctga
     4501 aaacggtaaa ataatgattg aaatggtgtt tttcttcagt ctgagaatcc ctacctaagg
     4561 ggttcttttt atgtttaaaa ataaatacac gtggaaaaca ttatatgtag ccaaaatcaa
     4621 aggagagata tataatgggt aaaaaaatag caacagttat cacagattta tttgaagatg
     4681 tggagtacac agaccccgca gaagcattca aaaaagaagg acatgaagtc acgaccattg
     4741 aaaaagaatc tgggaaaaca gtcaagggta aagcagaaca gacacctgta accatcgata
     4801 aaggtatcga tgaggtaaac gccaaagatt ttgacgcgtt gttcattccc ggtggatttt
     4861 ctcctgacca actccgtgcc gatgaacgct tcgttaaatt tgcgactgaa tttttacaag
     4921 caaataaacc gatctttgcc atttgtcacg gaccgcaatt gcttatccaa acaggtcaat
     4981 tgaaaggaag aaccgttacc ggatttactt ccattctatt agatcttaaa aatgctggtg
     5041 caaatgtgaa agatgaagaa gcagtagtgg acgataacat tgtaacaagt cgtaatccag
     5101 acgacattcc ggcctttatc aaagaatcat taaaacaatt agaaaaataa gaccaacagt
     5161 catcacccat tttggggatg gctttttttg tggataaagt tgtgtataac taaaaaggca
     5221 agaaggatat atatagtggc gaacagaaat tcgtccacca aatctagcaa gtgcctgtgg
     5281 atatgtggat aaacactgtg aataacttgt taataagtag ggtataagct gtggaaatgt
     5341 ccgtgtaaag gcaaaaaaca tgacaggcaa taatacccat accagttggg cgagtagtgg
     5401 tttgtataca atttttaaat gagaaaggaa taatagaaag acttgtggat aacctgtgta
     5461 taactaaaaa agcaagatca tagatattgc gacgaacaaa tgttcaaaca caatatacca
     5521 aaatgcctgt ggatatgtgg ataaattctg tgtataactt gtgagtaaac cggggataaa
     5581 ctgtgcagaa ccaaaaattc agaaaataaa tgcgcaaact ttcgcaaatt gttgtattct
     5641 tatagaagag aatttgaaaa gaagagggga caaatgaata tacaaatcat aacagttggt
     5701 aaattaaaag aaaaatatct aacacaggga atcaatgaat acttaaaaag attgcaggcc
     5761 tatgccaaag tccaaatcat cgaactacct gatgaaaaag caccagaagt acttagccaa
     5821 gcagaaatgg agcaagtcaa gctaaaagaa ggcgaacgga tcctaggcaa gatcagtgat
     5881 gacgctcacg tagttgcgct ggcgattctc ggaaagcaga aaaccagcga acagttcgca
     5941 gcgggaatcg aaaaattgat gacttatggg aaaagcaaga tcgtgtttgt gatcggtggt
     6001 tcgcttggat taggggataa tgtgttgaag cgagcggatg aggagatgtc gtttggaaaa
     6061 ctgacacttc ctcatcaatt gatgagatta gtattggtgg agcaggtcta tcgagcgttt
     6121 cggattatga gaggggagcc gtatcataag tgatgcggtt tttaataata ctgtttggga
     6181 atatcatctt tccggttgta ttttcttaga aatatttttg ccataaactg ttcgtcatat
     6241 attcaagttt tttcatatta ctttgtgcta aactaaaaga aaacataaaa aacagtattt
     6301 aagaggacac ttacgaaaaa aatcactgat catgaaaaag taaattatta cgccaaaaat
     6361 tttaattcag tcaataagct ggtcttcaag ttgagcaaac ttgagactag aataaactgg
     6421 tgagaaaagg gctataatgt tagctagaaa tgccagtctg ctctttttca gtgatttcga
     6481 agtaaaccaa tgttttaaag actttttcgt ttatatatta tcctctagac cgaatctctg
     6541 gggagattcg gtctattttt gtaaacgagg gaggagatca acttgtgtgt gtttaacaaa
     6601 gagcgttttg cggaaacgct ttttttgtat ggcaaaatta cccgaaaatt ttattgtgca
     6661 tcaatgctac tatcaagatt gggaaatgat tgtttgttta gctgagaata accgtccatt
     6721 atatagaggg cttttttatc aagaggaatg gataatagca gaaaaattcg taataggagg
     6781 tgagaattaa tgaatttggc gcaaaaactt ctatggtgtc agagtcagat gatgcattat
     6841 gaagaaattc ctatagaggt aaaaacaatc agttatgaag aggggttatt ggagaagagt
     6901 gaattaccta tagaactaga acaatttcta agtagacatt gttcagaaaa tgaatggaat
     6961 atagaaattt ttcaatggaa ccgatgccaa acacttatat aggtggggta gatacttttt
     7021 tagagaattc caaagtatgt tggacctttt ggattaaaaa cagtgatact ccaataatga
     7081 agaaatatga gcaacaataa cgaattagta atatatgtaa ttatctatcg aaattcgtag
     7141 atgtctttta tattatttag gaagattaaa aaaagcacgt tttatgaaca gtacttcctc
     7201 aatctaaaaa aatttaatca gattgatttc ttctttttta ggttaaggtt tggattatcg
     7261 agaaagtgac tatgcaacaa tgtttttata attgattatt caacgcaaaa agcccgcaaa
     7321 ttacgctgta taaaagctta gaagttgcgt agaaatattg ctaggataaa gatgtatgag
     7381 agagggaggg aaacgaacac attgtttcac gaaccaaagg tacatgaaga ttgtttggca
     7441 gagctgtata aagaattatc ggaattgatt ggccttgagt caatgttaaa attatacgtc
     7501 gttttaaaag gacaacaaat caattttcca acaagattat atgcaggaga aaaagtaaga
     7561 gcaaagatct atcagacata cgatggggaa agttctcata agttagcacg tgaatatggc
     7621 tatagttcta gatggatgca acagattgta aaagaatata gagaggaaaa agaaaatgaa
     7681 aaaatggggc attgatagtt taatgattgt cagctttttt cttcttcctt tttatcaagt
     7741 aacaggaaca gttgggatta ttactcaccg acaaagctat gcggggtatt ctctgttaac
     7801 agaccccatc gcttggttat tcttatttgc gccaattgga caacaagaaa gttggttaaa
     7861 cttagagagt catcttcaca ttggaggatg gttatatctt cttctattaa taatagaaat
     7921 tagtcaagaa attttacgga aaaggagtat ataaaaaatg gatagagaga aagtttggtt
     7981 aggggtacaa aaatatggca ttacgatagg tgccgctgtg agcattctaa gtttattttt
     8041 gacgatgttt atttcaggag atacagttag agatcaattg acacaacgtt taggagggag
     8101 ttcggcacac acactatttt caggaatgga ggtcctgttt gggacggctt attcggaggg
     8161 tgttacatta ggatatttat tagtagcgtt tccggtgcta ttgttagcca gtgtatttgt
     8221 agtcagtttg aaaaaatatc gttctatgat tcaaataacg acaccaattt tgtcgatact
     8281 ggttttgttt attgtaagaa gtcaaatgaa agcagcttta tcctttaccg ttaatcatgg
     8341 ggcgaatgaa tactatgtaa aagggggaat aggattttgg cttgttttat taattgattt
     8401 ggttatgatt gggctatgga ttattcaaaa gtatcagttg aaaattacta aagacaactt
     8461 aagaagtttt atagataaga aagactggaa tgagttgaaa aaataattat gaagagcctg
     8521 ggatataaat caaatttttg cttggggtaa aagataaagg caaagataaa aaagaatcgc
     8581 ttaaaaaatc catttctaaa aatggatttt aagcgattct ttcattattt cgacttatgt
     8641 accagccctt tattttttta aaagtgtgga aagtgacgga tatatagttt aatctgaaaa
     8701 gatatagata ataaacagga gtgaaagtga cagtgaatat agcttaaata aaatgaaaat
     8761 aggcaattac aattattctt tttgaatgga gatatcggtg atagaaattt attccaagaa
     8821 ttagaagaaa ctatttatag aaatataatt aacattttga aacatggctc ttctgatatt
     8881 gaaatggatt ttaaaaatct gttatatgaa gaatcgcaga gtgtccaaga attattagga
     8941 atagcatgct tcatgttttt tgctaagatt tataatgact tcattggttc caaaaatgta
     9001 gagaatgtaa ggcaaataga taatttaagg caattgaaaa aaatgactaa atatttagtt
     9061 agtaagtacg agaatagtac gttttttgat gaaaaagctt ctaatataca aatattagtt
     9121 tactatcttt tttataaagg atatgaagag aaatatttat atacaaaaga cgtgaaaagc
     9181 aaaaaagata ttactgatat gatgattgat gaaggtatta ttgatgacaa tgttaatata
     9241 aatactattt ataaacgaat cttcctttga gattaatttt acactctctt aaaagttgtc
     9301 tcaacttcta tcctacatcc agtttaagta ttgctagttt taaattcgta aaaacagatc
     9361 aaattctctg atttataatc ctgtcccttc aaaggggcag tttttttgtt taaccaaacg
     9421 gtcaggattt ctttaacgta gctctaggta gaattaataa cgcttatgta tcagcttatt
     9481 ttgtttacga caaattcgta gataaagttt ttttttttca tataataaaa gttgtaaagc
     9541 agatagctag ttttacaaaa aaatcaatga ggtgaaaaaa tggaaaaaaa agaatgggaa
     9601 aaaacggcac aaattgttca agaaggattt ctgcaagaag tagaggagca agaaattgga
     9661 gaagagtcag gtggggcttg gtggaatgtt agtaagaact tgggtaataa ggggcggatt
     9721 tgtactttaa caaaagaatg tcagtctatg tgtaattaaa taggggggat attgatatga
     9781 cgaaaaaaga atacgggctt cagcgaatgt cgcaactaga tcagcgggat ttcttaaaag
     9841 aaattgaaga acatgaaaag cagaatcaag ttagtggtgg atggggctgg aaggatttaa
     9901 gtaagagtct agggaataaa ggttatgttt gtacgttaac gaaggagtgt caaaaactct
     9961 gtaggtaaga aatacgtctt tttatagagg gaggatattt atgacagcat taaaaccaga
    10021 gacagcgatt aagcagtggc ttccattttt tccggaattt aaaaaggcgg aatggaaatt
    10081 aactgctcta ttagatcaat cgaatatcct gaaggaagag ccagtacgga catgtgatct
    10141 ggaaaaaatg atttcgggtt ggtcgggttt agaagcaaac agatataaca aaatggtttg
    10201 taaggatgtg ttatttccta atgcttttta tcctattatc cacaggtatt atcgtgatat
    10261 agaccgattt gtgtcagaag agccttttat actggataaa gagagtgtta agcaagctat
    10321 tttctcaggg ctgatggaca agctttcgaa cttaggaaat cgtgttttag tcaaagattt
    10381 aacggagcaa aagcagcaag ggtatctgga agggcattct ccggaagcgc gtttttccta
    10441 ctatgctaat gtgctattaa tggataagtc atatctcctc cgcttctatc aaaagtacga
    10501 tgcgttgctt gctttactag ttcagaccgt ggtcaaccag cttgcttttt ttaaagaagt
    10561 gattcttcaa acgaaacatc ggtgtttgga tatttgttcc ttagttacaa aaccagttat
    10621 tggcattgtg ggatttggcg gggatttagg ggattctcat aataatggta agtctgtatt
    10681 agtcattcat tttaatgatg ggcaaaaagt aatctataag ccacgttcgc ttagtttaga
    10741 agttactttt aataagctac ttcagcagat taatacgtta gacacaggat tagcaccatt
    10801 taaaaccgta aaatcggtag ataatggaga ctatggttgg atggagtata tcgagcatag
    10861 gccctgtgag cataaggaag aagttgcttt cttttaccgt aacattggac agcttatatg
    10921 cttactatat tttttaaatg gaaaagactt tcatcatgaa aatatcattg ctgctgggaa
    10981 atttccaacg ttgattgatt tagaatcgtt atttcacaat gatgatgggg aagaaactgt
    11041 agcagaatct actatttatc ggagctttta ccggcgatta aatcaatccg tccaaggaat
    11101 tggcatctta ccacaatgtc taaaaaataa ttcttatata gattttatta gtgcagatgt
    11161 gggtggtgtt agtgctgaga aggaacaatt atcaccgttt aagagcaatg tgatttttaa
    11221 tcgctatcga gatgatattt atatcggaaa agactacgga ctaatcagcg tgcagcaaaa
    11281 catcccaatc tataagggag atagtgtttc tgcaagtgat tatgaaggag aaataagagc
    11341 tggtttttcg caaatgtata cgtgggtgct gggaaataaa gcgtggtttt atgaacaagt
    11401 caataccatt ttcagaggga caatgaaccg ctatattatc aaaccgacat ttttatatag
    11461 tcaactcctt gctttaagtt tccatccaca tgttttaact tcaaagttaa atagaaaagt
    11521 attattgcat cgaatcggaa tgaatcagac tgatagaaaa aaagcgttgt ttcgggcgga
    11581 gctaagtagc ttggagaagg gggatattcc atacttcttg acgaaaataa cggataccca
    11641 tctctatgat caagcgggct tattagcaga agattatttt tcgcaaacgc cacttgcgag
    11701 ctcattagtt aaaattgctg atagtagtga agcagataga gcgttccaac tttatattat
    11761 aaaacagata tttgctgcta aatgcgctga tcaaacgaaa aacataactg atattgcatt
    11821 taagcaagaa gctgatttgc cattgaagaa agcgcaatgg ctggaacttg ctaaagcaat
    11881 gggagacgaa attattgcca atgcggtcga aatggagtcg caaggtgaga gaattgtcac
    11941 gtggattggg attaattttg aggggcaaca ggatcagtat tgggagcttg actttattgg
    12001 aaataacttg tatttgggaa atgcaggaat tgcacttttc ttaggatatc taggagatgt
    12061 aaccggatgt gaacgctata ccaaatttgc taaggcggct gttcgcgctg tccaagaaga
    12121 attaacatcc attaccgggg aagaggctga attgattgga gcttttaatg gagttagcag
    12181 ttatttgtat gctattggaa aactgaatga attgttagtc ggcgagtata ccaattatat
    12241 agaacaatct cttgctgttg ttcataagtt gattaaaaaa gatacgaact ttgatattat
    12301 ctcaggttca gcagggtgta tgctcgtatt aataaatatt cataacagtt tccaagcaca
    12361 gccagacata caagcgaaaa ttttgcatgt catcgaggaa tgctatcaac atatttgcat
    12421 aggggcaaaa catatggatt caggaattca ctggcgtcaa aaggaattag accctttagt
    12481 aggatttgca catggaaatg caggaattat atacagtctt actaaatatt atgagatgac
    12541 agggcaggaa aattgtttat cacttataaa acaagctctg aattatgaac gtcagtttta
    12601 cgatgctgaa aaaaaaggtt ggcgcttttc ggagcagcaa agtgatattt ctctgggctg
    12661 gtgtaacggg acgcctggaa tattggctag tagagtggcg ctgttaaaaa gtggttttcg
    12721 ggataagcgt ttggaagaag aaataactat tgcgttacaa gaaatgcaaa ttaatggctt
    12781 tggtaataat ccgtcccttt gtcatggcga tttcggaaac ttagaaataa cggctgctgt
    12841 ggcacaggat ttgcaagatg ataatttatt aaatagctgt tttgctacgg tacagcattt
    12901 atatgacagt tatttaaagc gaaattggca agcggggtta tttaaaggaa cagtctccta
    12961 caatctaatg gtgggattag ctggatgtgg atatgcactc ttacaggcat ataagaatta
    13021 ttctttaccc aaaattttac tattagatta aaaggaggcg aatccgattg gtaacagtga
    13081 tgacattcaa taatgttagt aaaaagtata aagaaaaatc agttttaaaa gatatttgtt
    13141 ttaccgtgaa gtcacgtgaa attataggat tagtcggggc taacggtgca ggaaagacaa
    13201 cattgatgcg cattttagta gggctaacca aacaatatga aggagagata cattccgaat
    13261 ttttaaaacc acagattgga tgtgtgatcg aaagtcctaa tttttatcct tatttatcag
    13321 gctatcaaaa cttactacat ttttccaaat acacaacaag tgataaaagt gaggttatag
    13381 aactacttga tatgcttggt ttaatggatg ctgcacataa aaaagttaaa acatattctt
    13441 tagggatgag acaacgctta ggaattgctc aagctttatt gggtcaacca gacattcttg
    13501 ttttagatga acctacaaat ggtctcgatc ctcagggcgt acagtcgatg cgtcaatatt
    13561 taaagcggat tgttaagacc agaaatgtag gaattctgct ttccagtcac atcctctcag
    13621 agattgagaa aatatgtgat cgagttatgt tgttgaaaga tggaatactc actgagaata
    13681 ttcgcacatt agtaagtgag caagcacaca atgtcgcgta tcaatttaaa acacccgaac
    13741 cgacagagct aacgaatttt ttgcagcgaa aacattttaa ggtaaagcga tttggacaag
    13801 tcgtagaagt acaattgcct aaagaaaaaa ttttttcgac tattcgggca atcatccagg
    13861 aaaatcttta tttcgagagc gtgactgcaa aagaagctga tttagaagag caatttatgc
    13921 aaattgtagg aggggataaa tcatgatgac aattgtacgg ctttctttac tcgaagtgaa
    13981 gaaaattggt agcagaccat acagttatct cgttctacta gtagcaactt ttgcgagtat
    14041 cggaatgggt gtagaagtgt tgagcagtga tacattcagc atgacacata tttttctgtt
    14101 tttcgcgatg attgccgaat ggatcattat ttattatgga gcaaaatcat taggcgaaga
    14161 attttctgtt aaaacatcca ccattatctt cacgaagaat gtatcgcgaa aaatcattct
    14221 gcttagtaaa ctaactagct tggctctaat cggtttaatg atggggatta tcagttcaag
    14281 cattgcggtt atattccaat atttattaac aggcaatctg acaggggagt ttctgattaa
    14341 ggaagcgtta tttaatacga ttgcttacat cctttttacc atgttagtag gaagctttgg
    14401 tattttagtt gccagtctta cgatgaattt gacgacagcg ttattaatat ccattgtcgc
    14461 ctttcaattt ttaccagctt tattggaaat gaccgttgaa aaattttcgt ttctaaaagg
    14521 tggtatggaa tatattccct ttcattcagc gattaagttt ttagaactgc atcaattcgg
    14581 aacagcaaca ttagttggga ttatcggtgg gattatattg ttcacagtat gtagtgttat
    14641 cctcattgat aataaagact tagtttaaca caacaaaaac gcatataaaa ggagtagaag
    14701 aaaatgacaa atcaaaaaaa agaagtaatg aatgaaaaag aacaaaagtt agaggcagaa
    14761 ctacgagagc ttagcagcca tgaagacgaa aatggcggtt ttccatggac tgtaacggta
    14821 ccgttatcta tagcgctttg tccgactgca aaatgtacaa gtaaatgtag ataaatctgg
    14881 tcaaatagga ggatagaaca cgatcctcct atttgataga tagaaatcat gcacattccg
    14941 taattatatg tactgataat tctttgtttt ttcttattag tgtcgtattt ctttgccatc
    15001 cactacttct gtcatattat gaatgaaaaa ggagaatcat tatgcaatgg aaagatgatc
    15061 aaactggggt ttttgataat ttttataaag cagatttgaa tttttttcaa atacaagctc
    15121 acaaaataat gaaccaattg gacacgaaag ggttagtaaa tgtagaacaa gttgttcaag
    15181 cgctttgcct agaattaaaa cagcgcttga tgagttattg ttcaggcgtt ctgcttacca
    15241 actttcaaaa atggaaaatg acagaagtaa gtaataatga aaattatgct atctataatg
    15301 aatctttgtt aaatgaacaa gttagaacaa agttgttaac agcttatcca gttatgaata
    15361 agttgattgc gaggacgata cgacaacagt tggagcaact atatgaaatt atcagccgtt
    15421 tcttgcatga tcgggaagcc ttacaagtcc agtttaaggt ttcgctacaa tgtcttgaaa
    15481 aggtggagca tctaaacagc gacccgcata aagatggtag gaatgttgtg ctacttacgt
    15541 ttacaaataa taaaaaaata gtttataaac cacgttctct agcgggagaa acgactttta
    15601 atcgcttttt ggagtatctc aatacagcgg gtgctttacg ttatgcactg aaaaacacaa
    15661 agattttaga tcgagcagct tatggctggc aagaattcgt tatgcaaaag ccttgcaata
    15721 ccgtttcaga gattaagcgc tatttttatc gagttggtgc ttacagcgca ttatttcagc
    15781 tcttgcaaac aagtgattta cactatgaga atatcattgc tgctggagaa tatccgctct
    15841 ttatagattt agagacactt gttagtgtaa aggcgaaaaa gaaggcgcaa gaaacggtcc
    15901 tagatttatt ttataatgaa gtaaatggat ccatcattgg ctcattgcta tttccgcagc
    15961 aactaattgg tagtcaaaaa accgctgatt tatcaggact gactggtgga tcactgaaaa
    16021 tagaaaaagt aaaaataatt gcaaaaggta caactgatat atgcgaaaaa acccaagtta
    16081 cacaacttaa ttgtgtatca aatcaagtta cattaggaaa agaaagaata gatccaaatg
    16141 agtatttcac agatatttta gcaggtgtta gcgattgttt taaaatacta tatgaacaaa
    16201 aagatttttt tgtaaacgaa attgcagcag gtaaattggt atcgggcacc tatcggcaag
    16261 ttttaagacc gacccatgtg tatgcgaagt atttagatag cgtttatcga ccagaatact
    16321 tagaaaacac acaaaaaaca aaacaactgt taaacatcat tacagaaaca gcagcgcata
    16381 aaaaacgaac acaaatcgag ttatcggaaa tgctgaataa tgacattccg cattttgtgt
    16441 gtgcgagtaa ttcaaccact ctacaagcta gtaatcaaca aacggttgag aattattttg
    16501 aaaccacacc acagcaactt gttgaaaata aatttaagca attaacgaag caagaaataa
    16561 cgaaacaaaa gtactatctt cgactggcat tcaacctcta tgcgcaaaat aagcaactag
    16621 ccaatgaggc tgatctacta gctgattttg ctcccgatgg tgatttcaat gataaattac
    16681 ttgatttatt tgaaaccaca gctatctggg attgtaagaa ggaaaaatgc acatggctat
    16741 taatagataa tgatggagaa acatatgcat tatcaccatt gataccatct ttttatctaa
    16801 atgccggaat aatttggtat ttagcaatag ctggagagca gcgtcagcaa atggcgtata
    16861 caaaaatggc taaaggggca atcaaaggga ttactgagct tccgaaatct tttatgggag
    16921 aaactccttc tgcttttgcg ggctattatt cattaattta tttgtattac aatcttagcg
    16981 ttttatggaa agataaaact ttgctacatc agtcctatca actaattaaa agcatcagtg
    17041 ttgatcaaaa cacctccctc gagcagattg attatgtcaa tggaatctcc gggatgattc
    17101 atttattaac tcgtatttat gaaaaggaca agcaagattt tattctggaa acggcttgta
    17161 tgttaggcga gaagttagat gcaagcttga aatcagcaga agcaaaaaca ggcttagcac
    17221 atgggctttc aggatatgca ttagcacttg ctagcttatg gcagcataca aacaataaaa
    17281 cttataaaga gagaacgcta aaattattgg aagcagaaga tcaattgttt gattcaattt
    17341 caggaaattg gatcgatgtt cgaacaagcc aaagtaaatt aaactattgg tgttatgggg
    17401 catggggtat tttgctagca agaaagcaaa ttaccatata tttaaacgat cagacaataa
    17461 gccaatcttc catttgtatc cgagccttaa aaaatgcttg ggagatgaaa gaaacatctc
    17521 ttaataacag tctttgccac ggtaatgctg gcaatggcat aataaggcaa ctgttagcag
    17581 atatagcggc ggaaaatggg ctaaccacca tgcagaatgt attgaatttt actgaaaaac
    17641 catatcaaca acttccaaca ttgcaattta tgcttggtct tactggcgtt ggttatgcct
    17701 tattgcgtca agaagaaccg agcctcccag ccatgttaga tttatcgcta ttaagtagtt
    17761 aaggaggaac ttcaattgaa aaaaagacgc gtaccttatg tggaacaagt gcaagccacg
    17821 gaatgcgggt tatgtgctgt ggcaatgata ttgcgatatc acaaaagcta tgaaacgttg
    17881 catgacctac gaacaagtgt ggatactggg agagatggtt cttcattgcg acagttaaag
    17941 ttgttattag aagagcatca ttttaaagta catatatatg aagcctccag caatggcttg
    18001 aatcagatag cactcccggc aatcatcttt tgggaaaagg agcatttcgt ggtcttggag
    18061 agtattcaaa aacaagcgta tacgattatt gatccagcag ttggcagacg tgtaataaaa
    18121 acagatcaat tccaagccgc tttttcaaat tttgttttaa ctgcaaaacc gaaaccatct
    18181 tttgagccaa aggcaagaag tgaaaatcca tggaaaacga taatttctga ttcattaatc
    18241 aataaaaagt tagtaggaca agtgattgtt ttcgcccttc tttcatattt ggttacccta
    18301 ggactaccta ttatcgtgca acatattata gatacactgg cgactttcaa tagtcaactt
    18361 attatacagt tggtctgcct aatgatggtg ttatttggga tttacggatt tgctctttat
    18421 atgcgagggc aaaagttgat tgctttacaa caagttattg accgatcttt aatgggaggc
    18481 actttttcac atctccttaa gctaccgtac aacttttatg aagttagaac atcgggtgat
    18541 ttacttttca ggatgaatac attgactgtg atcaaagaac tattgtcaga agatataatt
    18601 acagggatta ttgatcttgg tggcgttctt tttgtagcag catacatgtt ctatttatca
    18661 ccagttttgg ctggagtcgc cttgctagtg tttatactta atgggatttt tattattatg
    18721 accagaccga gagtactcga attaaatcag agtgagattg cagagagttc taaactacag
    18781 actatacaag ttgaatctat atattccatt ttaggtgtga agttagctgc tttagaagaa
    18841 catgtacgtc gaaactggta cgcccaattt aaacgagttt taggctctta tcaaaaacga
    18901 gcaacatttt cgaacctatt cacaaccgtc acaagtcttg ttcaagttgg tgcccctttc
    18961 ttagtattga ttgtagggat tattcaatat cagcaagctg ctctaacctt gggcgaagta
    19021 atcgcattta atagtatttc agccattttt tttagtctaa gtacggcgat tttcaatacg
    19081 tataataaat acttagtggc ttcatctttt cttgaacgtc tacaagatat tcgagaagca
    19141 aaagcagaag tttctaatag taccggtgtc caaccccaat tagaggggga cgtaactttg
    19201 cgtaatgtta gtttctccta ttcaaagaac tcgcaacgtg ttttaaaaga tattaattta
    19261 aaaataaaac acggcgaaaa aattgcgatt gtcggatctt ctggttctgg gaaaagtaca
    19321 ttagccaaat tagcgctggg cttgtatacc ccaacaaggg gtgagataca atacgatggc
    19381 atatctatgc tgacccttaa taagcaaaat ctgcggaaac aaatgggtat tgtaccacaa
    19441 gatattaact tatttaataa atcaatttta gaaaacattc ggatgaacca ggaaaatatt
    19501 tctcttagag atgtacagac agcggcaaaa ctcgctcaga ttcatgaaga aattgaagca
    19561 atgccaatgg gatatcacac attagtgtcg gaaatgggat tgaatttatc aggtggtcag
    19621 cggcaaagaa ttgctttagc acgtgcattg attaataaac cacgtgtcat tgtccttgat
    19681 gaggcaacga gttcgctaga tgctgtaaac gagcaaagag tagcgcaata tttaagtaat
    19741 atcggagcga ctcggattat aattgcacat cgtttatcaa ccattattga tgcagacaaa
    19801 atttatgtaa tgagagaggg tcgtattgta gaagagggca agcatgagga actttttcag
    19861 cgcaaaggat attattatca actatatgcc gcgcagctaa gtcatcaaaa atcaatgctc
    19921 acagcgtaat aaggaaaata gtccgtgagg tgaaatttgt gaggagatct attttaggga
    19981 aagaagtagc gactatctcc tttacaacac ttgaaatgtt agaagaagct aatcaagctg
    20041 ttgttccgat tttggagata tttgaactat taaaacaata tgcacccaaa aatagtatga
    20101 aaaaaaattt ggattttcga atcgtgttat tgattgatgg ctgtttatat attaaaagaa
    20161 taaacgagga tagtatcgtt gtctttcaaa acgatttatt agtagaattt aataaggata
    20221 aacagtattt atttttgtta gaagggggat tggaacaaag tctcttacaa ttgatgcttc
    20281 atatcaagcg aagttttcat gtagtagaat ttcattccat tagtttgcaa gcgtggaatg
    20341 ttactatgat attgcaagta gagctgggaa tacaggggaa taacgttaag gaagaaaaaa
    20401 caaacactag cgacttgtag ttttgattgg gaagtacgct aaagaaggga aaacgatttt
    20461 ttatgaaaaa aaaggaaata gtcctttgta ttcctgtatg cttgtaataa gcaggaggag
    20521 gaaatttcta tggatattaa aatgactggg tggaatttgt ggggtatcga acaccgtttg
    20581 gctaagcggg tattggaaag gttaacagct ggggaggcta tgagtgagca aaagtttctg
    20641 aaatgcaagc taggcattga agcattaata aataatatgt ttaagttgag tattgtatat
    20701 gcggttgcct ttgtaatgaa tactttccta gcaactcttt ttgtccattt aggtttttta
    20761 gccattcgaa cgtttgcata tggggcgcat gcaaagagct cggttggttg tataggaata
    20821 agcacgcttg cacttgtcgg acttcctttg cttatccaaa agaccttttt atttccgcga
    20881 gtggttctat tactagctgc attgctaata gcttatggtt tatgggaata tgctccagga
    20941 actactgcta aaaacaaaat cacaagcgag ataaagaaaa aacgactaaa aaaacgagcc
    21001 ctttttagtt gctttctcac catagtaatt agctcgttgc tacctctatt ggaagcaaat
    21061 ctgcttctaa ttggaaattt actggcagta tgttgtatca tacccgtgtt tattaagaaa
    21121 ggagggaatc aagatgaaaa aattagtgat taatttgttt gaaatgtttg gatcgcttaa
    21181 tgtgagacag tgttgttttc ttttgtcaga tgaaatagaa attcctgatg aattagcgga
    21241 atagtatcgt ttagttaatg gagtagaatc tatctatgtg aagtggtata ctatttgtag
    21301 acattcatat agaggaggga aatacttgga agttgcaata ggcatcatcc tccagacact
    21361 tttactccat ctcaatggaa agatactagt acataatagg aaagtgacta tcagtgaatt
    21421 cgtttttcta accgtagttg cagttataat ggttttaatg tataattatt taaatttttt
    21481 tacgtctatt gtaatgattc ttaatatttt gattattaat tatttaaaat accataaatt
    21541 agtattggct gtaggggtga cgtcatatgc tactatcatt ttagtgctaa gcgatcattt
    21601 agccactatt atggaagtgt atgttctgca aatcaatcaa acccatatta actataccta
    21661 tgtttttgcc catctcggaa ttcaaattat cctatctgtt ctcatctcat attgggtagc
    21721 taatatgata aagagagtgg aaaaaaagtt agggttagat atagtccata atatatttgt
    21781 ggccgtattg ggcttagcaa caatgattgt ctattataca agtatttatt tagggttttt
    21841 cttaggaaat gctttccctt tgattcagct caatttgatg ttttttatcg gctatttggt
    21901 aattacatta ttcattttct ttttttacat gcatgcacta aaaaataaat atgaagtaga
    21961 acaaaaggaa atagagtatg aatcaatgaa tcgttatacg gaagcgatgg aaaagcagta
    22021 tcatgaggtg cgtaaattta ggcatgatta taaaaatata ttgtcttcga ttgatgatta
    22081 tcttttggaa aatgattatg aaggattaaa aatatatttt ttacataaaa tcaagccatc
    22141 ctcagaaatg atagatcgaa ataattttaa acttaatgac cttagaaata ttaaaataag
    22201 agagctgaaa agtatcttat cttttaaatt gatatctgca caagaggcag gtattgatat
    22261 agttatagaa gtaactggac aaatcaaagt agtacctacg gatacaatta tcttagtcag
    22321 gctgattggg atcatcttgg ataatgctgt agaagaggtt caattcctag gaaagggaca
    22381 aatcgctgta tcgctatttg aagattttca ttctgtacag atcatcgtcc aaaatacatg
    22441 tcgagaaaac attccaaaga ttcaccaact aaagaaagag ggcttttcga caaaagggga
    22501 aaaccggggt cttggattaa gcaacatgag cgaaatgatt aatcaaacgg ctaatttact
    22561 attagagact acgactgagc cgcgattatt tatacaacgg ctaattatcc aaaaagagag
    22621 aaggtaagca catgttatct atttttattt gcgaagatga ggataaacag agagagaaag
    22681 tagaaacgtg tataaaaaat tacattttaa tggaagacct ggatatggaa gtggtattat
    22741 ctactgcgaa tccaacagaa gtgttagact atgtagagtc gcatgatcat actgtgggtt
    22801 tatacttttt agatattgat ttgcagcatc ccatgaatgg cttgacactc gctgcagaaa
    22861 tcagaaaaat cgatgattta ggcaaaattg tatttgtaac cacacatgga gaaatgtcct
    22921 atcttacgtt tacttacaaa atcgaggcaa tggattatat tattaaggat tatccagaag
    22981 aaatccaaca aaaaattcag gcctgtcttc gggttgctta tgaacgctat cgtaatgatc
    23041 gaatagggaa gaaacaattg tttcaagtga aattaggaga caatgttcgt tccatccaca
    23101 tagatgatat tatttttttt gaagcatctc cagcggctca tcgagtcatt ctccacttgg
    23161 aaaatagtga attagaattt tatggatcga tcaaaagttt agagtctata agcacagatt
    23221 tctaccgatg ccataaatcc tatttaataa ataagaacca cattatggaa atcaataaaa
    23281 atgaacgctt agtcataatg tcaaacgagc aagcgtgttt agtatcggtt cgtgcgttat
    23341 ctggattagt aaaaatacat aaaaggtaag attatttgaa agtcgtaaag aggtggattt
    23401 cttgtggcaa gttgtttacg tgaagaagta aaaatttata aaataatcta attctagagc
    23461 ctgaacataa gattgattat aaaacgaagg ctgtttacag tttcgacctc agactgtcgg
    23521 aaaaagtagt ttgcttttcc ggcagttttt ttttgtatga ttgtaatgaa aaatgcctat
    23581 ataaagaaac aacatctgtt agtgaaacat caacacattt ttgataatat attgactagg
    23641 tattgtggtt cataggacgt gaaattgtct atacggatgc tgcttttaac aacaaacatc
    23701 ctccaaactc tcatctctga aaagctggtt tgcttttttc gatcagccac ttttctgcac
    23761 ttgaaatcgg atgatcggta tgataaatga gcgtttttcg cagtttggcg tactcgtcgg
    23821 gtaaagtttc gtaggtaagg aaatgatatt ttaatgcgat gctttcaggg ataatgccga
    23881 ttcccagttc gtttttgcaa atctcaaaaa gtgtttcggc aatatttatt tcggagatag
    23941 aagcagtttc cacattgaga tctttcatca aagaagccag tgctctataa gaatagcatt
    24001 gcttactaaa gacgtataag cgttcctcag tcaatatttt ttgaagcgat atcccttttg
    24061 ttttgccggc gaagactaat ttatcttgag acagcatctc tgatatgact tgtttgtctt
    24121 gaagcagctg ctcattttct aattcagtaa cataagcaat cgttaattct ctatttacta
    24181 ctttatggat caattcgttg gtggttccgc tgacgatgga taatttttta tttgggaact
    24241 gtgtataaaa atccttaata atgtcattaa attgggttgg aaaagaagtc tggggaatac
    24301 caagcaaaat agtttcttct ttgttagtga taatagcagt ggtttcctcc cagagcaaaa
    24361 tcattttttg aaattggtga tagagttttt ccccgttttg agttagttca acgccgctag
    24421 aatgtcgaaa gaaaagttgt gtttgaaatt gtttctcgat attttttatt ttattcgaca
    24481 tattagattg taagtgatgt aattcgcttg cagcggcaga aatactttta agttcagcga
    24541 ctttattgaa agctttcatg ttctcgatat ccataacgta ctccttctga tatcaaaatt
    24601 aatgatatct atatatgatt tatgcatttc aaatgatagc gggaataaat tatactttac
    24661 ttagcattta aattcaagaa atgtaagtga tatggacaat tggaggagaa atcatgaata
    24721 aaaccattca gcaattagtc aaacatgttt cagtacgaga atttaaaaag gagcgtttgt
    24781 ctgatgaaat caaacaaacg ctagtaactg cagccagaag tggcgctact tctcattttg
    24841 ttcaagcttt ttctattttg gaaattacag atcaatcatt acgagcgaaa ctagctgaaa
    24901 ttacggatag tgcttcttat gtcaaacaaa cgggaacttt ttatgtgttt gtcggtgatc
    24961 tatatcgaca atcacaactt ttattggaag ataatcaatc tttagctggt ttaagaaata
    25021 tggaatcttt attagtagca gtagtcgatg ccacaattgc agctcaaaat atggttgttg
    25081 cagcagaatc attggatctt ggaatctgct atatcggggg aatacggaat gatatagcaa
    25141 aggttgcgga gttattaaac ttacctccgt ttaccatacc ggttttcgga ctaactgtcg
    25201 gagtcccggc acacaaaaat caagttaaaa cacgactttt gcctgaaaat caagtgagcg
    25261 aaaatcagta tccacatgat cgattcgcag atttaaaagc atatgaagcg ttaacgcgag
    25321 aatactatgc tttacgtgaa aaaaacggac aacaaacttc ttggccggat aagaatatcg
    25381 aattttttaa agcgatccga agaccagaaa tcgctgcttt tttgaaaaag cagggtttta
    25441 cgttggatta aatagctaaa aataacgtaa cttttaagac cggtgctttc aaagagccgg
    25501 tctatttcta tgttatttta aagttaaaga tatacaatga atgaatactg cttcaaaatg
    25561 tccgttgcaa cggacattgc caagtaaagc gctttcttaa aaatgagata tgctaaatat
    25621 atagaaggag ggcagatgaa atggcgaaaa aaacaaatcg tgagcagcat ctgttactta
    25681 ctctttttga aacacaaggg tacatgacag cagaggagct ggcgaatata ctccaaattt
    25741 cagccaaaac aatctaccgc ttgatcaaaa gaataaatga cgcggaagca aaagatccac
    25801 ttatcgtttc agagaagggg agaggttata aattaaatta cgaaaagtat ttgtctcaaa
    25861 aaaaatggca gcagagtaag gaggatatct attcaccgag tgaaaggcgt aaccgggtga
    25921 tggaggaact tctacttatt tctccaaggg caaaaaatat tcacaactta ttcgaagact
    25981 attatgtggg cgattctgcg atttttaatg atgaacagga aatcgcacgc caaatcaaag
    26041 aatatgagtt gacgctcgaa agaaaaaaac gaacacttgc tatcattggc gatgagcgta
    26101 atattcggcg ggcaatcgtt gacttagtag ctacattcag cacgatcgat ttagatgaac
    26161 ttgagagtat caaagtttct aatttgaata attatgatgt gctatttgtt attcgtcagt
    26221 tgcgagaaat agaaagttcg ctggcgataa cgatccctta tccatacagt gtcaacattt
    26281 tttcgcattt gtatatattg atttcaaggt tccgaaaagt aggtgctctt cagatagaca
    26341 aggagagacc actgacagag aaagagttgg cggagtttca cagcgatcca tatttgcatc
    26401 agatcgcaaa agacgtgatc agaaatgtag aaaactattt acatcaaaag ttatcagagc
    26461 tggaggtcta ctatttatat caatatctat tgtcttcacg gatgcaaggg aaatctcatg
    26521 gaaacgcaca taatttctcg ccaaaagtaa tgcagatcac acatatgtac ttaaatgaaa
    26581 tgactgcacg actaaacaat gatatgaaca atgaaacaaa ctttttagat ttggccaatc
    26641 atatcaaacc aatgatcaat cgtctggaaa ataagatccg aatcaaaaat gggctgatcg
    26701 agcagatcat gatcacttat ccagaaattt ttgagcaagt gacggaagtt tctgaaaaga
    26761 tcagcaaaaa ttatgatttg ccgcctatcc acagagatga aaacggcttt ataactcttt
    26821 attttgcccg gatacttgag acaaatacaa gtcctatcaa aaccattatt atgtgcacaa
    26881 caggcatcgg cacgtcggaa cttttattag caaaagtaga aaagcgattt ccagagttgg
    26941 aagtcattga tgttgcagcg agccgctatt ctaaggaaaa cctgcgcaag catccggaag
    27001 cagaactgat tttaactact gtccagctac cgcaagatct ccctatccag agcttggtgg
    27061 tcagcgccat gctgacagca gatgatcaaa ataggatcca acgcaagatc gaggagttgc
    27121 aacatggaaa ataaaaaatg gcttaaagct tatttcaacc aacctcttca aacgaaaaaa
    27181 gaaatgtatg aatttattgc gaattacgga gaaaatgatc agttaagtca tgaaaatatc
    27241 aaccgggcat tgcgggagcg ggaattagca agcaatttgc agatagcgcc gcatgttgtt
    27301 ttaccccatt tcgaaagctt ggctctgact gagagtagtg tactgatcat tcatctgcag
    27361 gaagagattt cgtgctggga tcaaactgct gcggatatca aattagtaat tgctatttta
    27421 ttgaaaacaa atgagtcgct tgaaataaaa aaagaaatcg cgttatttac cagaagctta
    27481 gcagatgaaa catttattca aaatctgctt tgcgctgaaa aagaagccat ttttatggat
    27541 tatttaaaga agatatagga ggaatttatc atgaagatcg tcggagtagc agcttgtaca
    27601 gtggggattg cccacactta tatcgcgcaa gaaaaattgg aatcggcagc tcaagaagcg
    27661 gggcacgata tccatatgga aacgcaagga acaatcggga tcgagaatga gttatcacaa
    27721 gaacaaatag atgccgctga tattgttatc ttggctattg atgtgaaaat agcgggtcga
    27781 gaacgttttg aaaacaaacg aatcattcaa gtgccaacgg acgtcgctat caaatcgccc
    27841 aaaaaacttt tggagaaagc aaaagaagtt gtaagccaag gtaatgcttc taactaggag
    27901 ggtcaaaaat ggaagtgaaa gatattgtag atttaaaaac agtcacaaca aatttaaaag
    27961 cgacaaccaa agaaagtgca ttacaggaat taagtgagtt attaaaggac aataattata
    28021 tttccgatat cgacggattt atgaaagatg tttacgctcg cgaagcagaa ggacaaactg
    28081 gaatcggcaa ttttgtggcg atccctcatg gtaaaagcga gtttgtcagc aagaatggag
    28141 tggcgatcgg tatcacagaa aatgagatcc catgggaaag tttggatgac catggagcaa
    28201 aagtcgttat tctgtttgcg gtcggaaatg atatggaagc tgcaaaagaa catttaaaac
    28261 tgctgtcatt atttgcgcgc aagttaggaa aggataaagt cgttgctaaa ctgctgaatt
    28321 ctgagagtgc cgaggatgtt gttgaagcat ttgcttgatt agagaagctt atcaaaatga
    28381 aaaaacataa aaggagagaa aagtgatgaa agcacttcgc aagttagatc ttaaaggaca
    28441 tttattaact gccatttcat atttgatccc tgtcgtttgt ggagcaggat ttttgatcgc
    28501 gatcggcatg gcttttggag gaagtagtca agatgcgctg gttcaaggga agtttacgat
    28561 ctgggatgct ttggctacga tgggtggaaa aggcttaggt ctgcttccgc tagtcatttc
    28621 gacaggaatt gcttattcga ttgcggctaa acctgggatc gcacccggtt ttattatcgg
    28681 attgactgct aacgcaatcg gtgctggatt tatcggaggg atattaggcg gttatttagc
    28741 tggttatctt gtacttgcgg tcttgaagta tgttaaagtc ccaagctggg caaaaggttt
    28801 gctgccaact ctgatcattc ccttcctgac atcgatcgtt ggtggtctga tcatggtcta
    28861 catcattggg gtaccaattg cttggtttac atctttactg acagggttgc tgaatggtct
    28921 aggttcatct tcgctatctg tattcggagc agcggtaggt atattgagtg gggtcgacta
    28981 tggtggccca atcaacaaaa cggtctttgc ctttgtactg acgatgcagg cagaaggtat
    29041 caacggacca atcacagcgc tgcaactggt aaacactgct actccgatcg gatttggcct
    29101 tgcttatttt gttgcaaaat tattccgcaa gaatatatat tcctctgtgg aaatagaaac
    29161 actgaaatct gcagtaccaa tgggtgttat taatatcgtg gaaggtgtta tcccgatcgt
    29221 aatgaatgat atcgtacgtt gcgtagttgc aacagctatc gggggagcag ctgggggagc
    29281 agtttcgatg ctgttaggtg cagatgctac ggttccgttt ggtggcgtgc ttatgctgcc
    29341 gacgatgtcc agaccatggg caggcgttat tgccttactg gtaaatatta ttgtaactgc
    29401 ggtcgcgctg gctttgatca agaagaacgt ttctaaacaa gaattggacg aaaaagcagc
    29461 agtagaagaa gaagatattg atttagacga tattcaaatt ttttaataca gaaagtggtg
    29521 caggaatgat gaataaagta agattttcac catcattgat gacgatggac ttggataaat
    29581 ttagcgaaca gatcactttt ttgaataact atgctgattc ctatcatatt gacatcatgg
    29641 atggccatta cgtgccgaat attacgttat cgccatggtt tatcgaagag gtacggaaaa
    29701 taagcgatct gccagtgtca gcccatttga tggtgactga cccaagtttt tgggtggagc
    29761 agttaattgc attaaaatgc gaatggatct gtattcatgc tgaggtattg gatggtttgg
    29821 cattcagact tattgatcaa atccatgatg cggggttgaa agcgggaatt gtgttaaacc
    29881 ctgaaacacc gatcgacacg atttttccct atatcgagct cgtagacaaa atcacgatca
    29941 tgacggtcga tcctggcttc gcgggccaac gttttataaa aagcacactc aataaaattg
    30001 ttgacttgcg aaatctgcgt gacgcaaaag ggtatcgata tgtgattgaa atggatggtt
    30061 cttctaatcg aaaatcattt aaagacattg atattgcagg acctgatatt tatatcgtcg
    30121 gacgcagtgg attattcggt ttgacagatg atatcgagga atcatggaat atcatgctga
    30181 aggattatga agaagcaaca ggtaaaaaag tagaagtata aagtggtaga gaatagtttt
    30241 tcatccgttg gagggtacag aaatgtttga taaaatagat gagttaggcg taaatacgtt
    30301 acgcatgtta agtatagaag caattcagcg agcaaattcc ggacatccgg gattgccgct
    30361 tggagcagca ccaatggctt atgcactttg gacaaaacat ttaaaagtaa atccgagaac
    30421 ctcaacaaca tggatcgatc gtgaccgctt cattttatct gcgggccatg gttcggcact
    30481 gctttacagt ttactgcatt tgtcaggcta taacgtttca ctagaagatc ttatgcaatt
    30541 tcggcagtgg ggctcagtaa ccccaggaca ccccgaagca ggtcatacgg atggcgtaga
    30601 agtaacaacc ggtccgttag ggcaagggct tgcaatggct gtaggaatgg cgatggcaga
    30661 aacgcatctg gcggcgatat ataatcaagc agatatttcc attgtcgacc atcatacata
    30721 cgcgctatgt ggagatggag atttgatgga aggcgtttct caagaagcaa gttcgcttgc
    30781 tggacatctc aaactaggaa aactgatcgt gctttatgat tccaatgata tttcactaga
    30841 tggtccgacc tcaaaagcat ttacggaaaa tgtcggatta cgctatgagg catacggctg
    30901 gcagcatttg cttgtggaag atgggaatga tttaactgcg atctcagaag ctattgaaca
    30961 agcaaaggca gaaacagaaa aaccaacgct tattgaggtg aagacagtca ttggatatgg
    31021 tgcacctcag caagggacga ataaagtaca tggagcaccg cttggagctg agggaatcgc
    31081 agctgtgaag gagaaacttg gctggacgta tcccgaatca accgtgccgg acgatgtcaa
    31141 aaagcgcttt acagagcaaa tgattgcaga aggggaagaa gtagaatctg cttggcaaga
    31201 acgtttttcc gcctatgaaa aagcgtatcc agaattggca aaac
//
