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Overview
1.1
1.2
1.3
1.4
1.5

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_LR134483.1 (Listeria grayi)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1 | cyclic-lactone-autoinducer | 24,379 | 45,135 |
Region 2 | lanthipeptide-class-ii,cyclic-lactone-autoinducer | 340,859 | 372,102 |
Region 3 | T3PKS,HR-T2PKS | 1,121,293 | 1,175,732 |
Region 4 | terpene-precursor | 1,289,853 | 1,310,734 |  |
Region 5 | terpene | 1,588,819 | 1,609,667 | Low | citrulline | other:other

NZ_LR134483.1 - Region 1 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 24,379 - 45,135 nt. (total: 20,757 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: glycosyltransferase phosphotransferase
EL241_RS00110: Glucose-specific phosphotransferase enzyme IIA

smcogs
  SMCOG1145: Glucose-specific phosphotransferase enzyme IIA

EL241_RS00135: glycosyl transferase group 1

smcogs
  SMCOG1045: glycosyl transferase group 1

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002667.2 |  | 0.37 | ribosomal | estericin A | Clostridium estertheticum
BGC0000881.3 |  | 0.33 | other (other) | toyocamycin | Streptomyces ahygroscopicus subsp. wuzhouensis
BGC0001808.5 |  | 0.33 | other (other) | toyocamycin | Streptomyces diastatochromogenes
BGC0000879.5 |  | 0.27 | other (other) | toyocamycin, sangivamycin | Streptomyces rimosus
BGC0001110.5 |  | 0.24 | NRPS, PKS | psymberin, irciniastatin B | uncultured bacterium psy1
BGC0001818.4 |  | 0.21 | NRPS | vazabitide A | Streptomyces sp. SANK 60404
BGC0002571.2 |  | 0.20 | NRPS | pyoverdine DC3000 | Pseudomonas syringae pv. tomato str. DC3000
BGC0001370.4 |  | 0.20 | NRPS | lipopeptide 8D1-1, lipopeptide 8D1-2 | Streptomyces rochei
BGC0002282.2 |  | 0.20 | other (other) | formycin A | Streptomyces kaniharaensis
BGC0002039.3 |  | 0.20 | other (other) | coformycin, formycin A | Nocardia interforma ATCC 21072

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002667.2 |  | 0.37 | ribosomal | estericin A | Clostridium estertheticum
BGC0000881.3 |  | 0.33 | other (other) | toyocamycin | Streptomyces ahygroscopicus subsp. wuzhouensis
BGC0001808.5 |  | 0.33 | other (other) | toyocamycin | Streptomyces diastatochromogenes
BGC0000879.5 |  | 0.27 | other (other) | toyocamycin, sangivamycin | Streptomyces rimosus
BGC0001110.5 |  | 0.24 | NRPS, PKS | psymberin, irciniastatin B | uncultured bacterium psy1
BGC0001818.4 |  | 0.21 | NRPS | vazabitide A | Streptomyces sp. SANK 60404
BGC0002571.2 |  | 0.20 | NRPS | pyoverdine DC3000 | Pseudomonas syringae pv. tomato str. DC3000
BGC0001370.4 |  | 0.20 | NRPS | lipopeptide 8D1-1, lipopeptide 8D1-2 | Streptomyces rochei
BGC0002282.2 |  | 0.20 | other (other) | formycin A | Streptomyces kaniharaensis
BGC0002039.3 |  | 0.20 | other (other) | coformycin, formycin A | Nocardia interforma ATCC 21072

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 25.88 out of 25.88
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.99 out of 26.06
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.85 out of 24.78
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.11 out of 24.78
Confidence: medium
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.60 out of 25.88
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.63 out of 28.19
Confidence: medium
Additional weak hits (4):
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.15 out of 29.25
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.53 out of 33.73
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.98 out of 29.38
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.54 out of 33.14
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
PsrA | Oleic acid responsive regulator
ZuR variant 1 | Zinc-responsive repressor

NZ_LR134483.1 - Region 2 - cyclic-lactone-autoinducer,lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 340,859 - 372,102 nt. (total: 31,244 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase
EL241_RS01730: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

EL241_RS01745: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000517.4 |  |  | 0.46 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000554.4 |  |  | 0.42 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000552.3 |  |  | 0.41 | ribosomal | SmbA, SmbB | Streptococcus mutans
BGC0002110.3 |  |  | 0.40 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0000525.5 |  |  | 0.39 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0001555.4 |  |  | 0.39 | ribosomal | colicin V | Escherichia coli chi7122
BGC0002005.2 |  |  | 0.38 | ribosomal | RaxX | Xanthomonas oryzae pv. oryzae
BGC0001787.3 |  |  | 0.37 | ribosomal | suicin 3908 | Streptococcus suis
BGC0000590.5 |  |  | 0.37 | ribosomal | microcin N | Escherichia coli
BGC0001229.4 |  |  | 0.37 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000517.4 |  | 0.57 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000552.3 |  | 0.56 | ribosomal | SmbA, SmbB | Streptococcus mutans
BGC0000554.4 |  | 0.56 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0002110.3 |  | 0.55 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0000525.5 |  | 0.54 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0001229.4 |  | 0.53 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000497.3 |  | 0.53 | ribosomal | BHT-Aα, BHT-Aβ | Streptococcus ratti
BGC0000516.4 |  | 0.52 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0001555.4 |  | 0.51 | ribosomal | colicin V | Escherichia coli chi7122
BGC0001311.5 |  | 0.51 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for EL241_RS01730

EL241_RS01720
Leader:
MEKKEWEKTAQIVQEGFLQEVEEQEIGEESGGA
Core:
W W N V S K N L G N K G R I C T L T K E C Q S M C N
Core with dehydrations:
W W N V Dha K N L G N K G R I Cys Dhb L Dhb K E Cys Q Dha M Cys N

#### antiSMASH-DB 4.0 matches for EL241_RS01720

100.0%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS01720_lanthipeptide
Lanthipeptides: EL241_RS01720_lanthipeptide
1
W W N V S K N L G N K G R I C T L T K E C Q S M C N
26
W W N V S K N L G N K G R I C T L T K E C Q S M C N
1
W W N V S K N L G N K G R I C T L T K E C Q S M C N
26
65.5%
NZ_CP034118.1 and 1 other:
NZ_CP034118.1 Lanthipeptides: EG886_RS06305_lanthipeptide
Lanthipeptides: EG886_RS06305_lanthipeptide
1
W W N V S K N L G N K G R I C T L T K E C Q S M C N
26
W W N+S +L G N G R C T L T K E C Q C N
3
W W N I S C H L G N T G R F C T L T K E C Q P N C N
28
62.1%
NZ_CP034118.1 and 1 other:
NZ_CP034118.1 Lanthipeptides: EG886_RS06310_lanthipeptide
Lanthipeptides: EG886_RS06310_lanthipeptide
1
W W N V S K N L G N K G R I C T L T K E C Q S M C N
26
W W N+S +L G N G+ C T L T K E C Q C N
3
W W N I S C H L G N T G Q F C T L T K E C Q P S C N
28
with 101 more sequence matches
Only the first 10 are displayed here.
60.7%
NC_021362.1 and 29 others:
NC_021362.1 Lanthipeptides: BALI_RS00925_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide
Lanthipeptides: BALI_RS00925_lanthipeptide
1
W W N V S K N L G N K G R I C T L T K E C Q S M C
25
W+N+S L G N K G+ C T L T K E C Q C
3
W Y N I S C Q L G N K G Q W C T L T K E C Q R S C
27
60.7%
NZ_CP006058.1 and 23 others:
NZ_CP006058.1 Lanthipeptides: BAMY6639_RS13800_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptide
Lanthipeptides: BAMY6639_RS13800_lanthipeptide
1
W W N V S K N L G N K G R I C T L T K E C Q S M C N
26
W+++S L G N K G C T L T E C Q S C N
3
W Y D I S C K L G N K G A W C T L T V E C Q S S C N
28
60.7%
NZ_CP063276.1 and 1 other:
NZ_CP063276.1 Lanthipeptides: IM743_RS02795_lanthipeptide
Lanthipeptides: IM743_RS02795_lanthipeptide
1
W W N V S K N L G N K G R I C T L T K E C Q S M C N
26
W++V S L G N K G C T L T E C Q+ C N
3
W Y D V S C R L G N K G A W C T L T V E C Q N N C N
28
60.7%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS01725_lanthipeptide
Lanthipeptides: EL241_RS01725_lanthipeptide
1
W W N V S K N L G N K G R I C T L T K E C Q S M C
25
W ++S K+L G N K G +C T L T K E C Q +C
3
W K D L S K S L G N K G Y V C T L T K E C Q K L C
27
59.3%
NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide
Lanthipeptides: CWT12_RS00385_lanthipeptide
4
V S K N L G N K G R I C T L T K E C Q S M C N
26
+S+ L G N G +C T L T K E C Q M C N
5
L S R K L G N T G Y V C T L T K E C Q R M C N
27
57.1%
NZ_FOBE01000018.1:
Lanthipeptides: BMW61_RS13085_lanthipeptide
1
W W N-V S K N L G N K G R I C T L T K E C Q S M C N
26
W++ +S L G N+G C T L T K E C Q+ C N
2
W Y S E M S A A L G N R G S Y C T L T K E C Q A C C N
28
53.8%
NZ_CP050134.2 and 3 others:
NZ_EQ973330.1 Lanthipeptides: CORMATOL_RS10565_lanthipeptide NZ_LR134504.1 Lanthipeptides: EL293_RS07240_lanthipeptide NZ_LR134504.1 Lanthipeptides: EL293_RS07240_lanthipeptide
Lanthipeptides: HBA49_RS00770_lanthipeptide
4
V S K N L G N K G R I C T L T K E C Q S M C N
26
+S+ L G N G R C T+T K E C C N
1
L S R L L G N N G R W C T I T K E C M P S C N
23
53.3%
NZ_LT985747.1 and 1 other:
NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide
Lanthipeptides: C8268_RS00165_lanthipeptide
2
W N V S K N L G N K G R I C T L T K E C Q S M C N
26
+ +S L G N K G C T L T K E C Q C N
6
F T L S D Y L G N K G G W C T L T K E C Q R S C N
30
53.3%
NZ_NTSF01000026.1 and 1 other:
NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21845_lanthipeptide
Lanthipeptides: CN325_RS21845_lanthipeptide
1
W W N V S K N L G N K G R I C T L T K E C Q S M C N
26
W W N V S +L G N G+ C T +K E C C N
4
W W N V S C H L G N D G K Y C T A S K E C M P T C N
29
51.7%
NZ_NTSF01000026.1 and 1 other:
NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21835_lanthipeptide
Lanthipeptides: CN325_RS21835_lanthipeptide
1
W W N V S K N L G N K G R I C T L T K E C Q S M C
25
+W N+S +L G N G +C T L T K E C+ C
4
F W N I S C H L G N D G S V C T L T K E C R P A C
28

#### MIBiG 4.0 matches for EL241_RS01720

57.1%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
1
W W N V S K N L G N K G R I C T L T K E C Q S M C N
26
W+N+S L G N K G C T L T E C C N
3
W Y N I S C R L G N K G A Y C T L T V E C M P S C N
28
50.0%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
2
W N V S K N L G N K G R I C T L T K E C Q S M C N
26
+++S L G N G C T L T K E C Q C N
6
F S L S N A L G N N G G W C T L T K E C Q P N C N
30
23.1%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
15
C T L T K E C Q S M C N
26
C T L+K E C Q C N
28
C T L S K E C Q P N C N
39
EL241_RS01725
Leader:
MTKKEYGLQRMSQLDQRDFLKEIEEHEKQNQVSGG
Core:
W G W K D L S K S L G N K G Y V C T L T K E C Q K L C R
Core with dehydrations:
W G W K D L Dha K Dha L G N K G Y V Cys Dhb L Dhb K E Cys Q K L Cys R

#### antiSMASH-DB 4.0 matches for EL241_RS01725

100.0%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS01725_lanthipeptide
Lanthipeptides: EL241_RS01725_lanthipeptide
1
W G W K D L S K S L G N K G Y V C T L T K E C Q K L C R
28
W G W K D L S K S L G N K G Y V C T L T K E C Q K L C R
1
W G W K D L S K S L G N K G Y V C T L T K E C Q K L C R
28
60.7%
NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide
Lanthipeptides: CWT12_RS00385_lanthipeptide
6
L S K S L G N K G Y V C T L T K E C Q K L C
27
L S+ L G N G Y V C T L T K E C Q++C
5
L S R K L G N T G Y V C T L T K E C Q R M C
26
60.7%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS01720_lanthipeptide
Lanthipeptides: EL241_RS01720_lanthipeptide
3
W K D L S K S L G N K G Y V C T L T K E C Q K L C
27
W ++S K+L G N K G +C T L T K E C Q +C
1
W W N V S K N L G N K G R I C T L T K E C Q S M C
25
with 101 more sequence matches
Only the first 10 are displayed here.
60.0%
NZ_CKMQ01000043.1 and 10 others:
NZ_CKMQ01000043.1 Lanthipeptides: AE832_RS11585_lanthipeptide NZ_CKMR01000002.1 Lanthipeptides: AD782_RS11690_lanthipeptide NZ_CKMR01000002.1 Lanthipeptides: AD782_RS11690_lanthipeptide NZ_FIXU01000003.1 Lanthipeptides: A1M11_RS11670_lanthipeptide NZ_FIXU01000003.1 Lanthipeptides: A1M11_RS11670_lanthipeptide NZ_LR216041.1 Lanthipeptides: E0F00_RS05465_lanthipeptide NZ_LR216046.1 Lanthipeptides: E0E82_RS05980_lanthipeptide NZ_LR216046.1 Lanthipeptides: E0E82_RS05980_lanthipeptide NZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00170_lanthipeptide NZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00170_lanthipeptide
Lanthipeptides: AE832_RS11585_lanthipeptide
2
G W K D L S---K S L G N K G Y V C T L T K E C Q K L C R
28
G W L S ++L G N K G V C T T E C Q C R
1
G W A Q L S F I S E A L G N K G A V C T G T I E C Q N N C R
30
57.1%
NC_021362.1 and 29 others:
NC_021362.1 Lanthipeptides: BALI_RS00925_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide
Lanthipeptides: BALI_RS00925_lanthipeptide
3
W K D L S K S L G N K G Y V C T L T K E C Q K L C R
28
W ++S L G N K G C T L T K E C Q+ C+
3
W Y N I S C Q L G N K G Q W C T L T K E C Q R S C K
28
57.1%
NZ_CP006058.1 and 23 others:
NZ_CP006058.1 Lanthipeptides: BAMY6639_RS13800_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptide
Lanthipeptides: BAMY6639_RS13800_lanthipeptide
2
G W K D L S K S L G N K G Y V C T L T K E C Q K L C R
28
W D+S L G N K G C T L T E C Q C
2
A W Y D I S C K L G N K G A W C T L T V E C Q S S C N
28
57.1%
NZ_CP063276.1 and 1 other:
NZ_CP063276.1 Lanthipeptides: IM743_RS02795_lanthipeptide
Lanthipeptides: IM743_RS02795_lanthipeptide
2
G W K D L S K S L G N K G Y V C T L T K E C Q K L C R
28
W D+S L G N K G C T L T E C Q C
2
A W Y D V S C R L G N K G A W C T L T V E C Q N N C N
28
57.1%
NZ_KE384107.1:
Lanthipeptides: G586_RS23925_lanthipeptide
3
W K D L S K S L G N K G Y V C T L T K E C Q K L C R
28
+ D L S S L G N+G C T+T K E C Q C
3
Y A D L S A S L G N R G S Y C T I T K E C Q A C C N
28
53.3%
NZ_CP043317.1 and 1 other:
NZ_CP043317.1 Lanthipeptides: FYC74_RS17680_lanthipeptide
Lanthipeptides: FYC74_RS17680_lanthipeptide
6
L S K S L G N K G Y V C T L T K E C Q K L C R
28
L S S L G N G C T L T K E C Q C
8
L S D S L G N H G G W C T L T K E C Q P N C S
30
53.3%
NZ_LT985747.1 and 1 other:
NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide
Lanthipeptides: C8268_RS00165_lanthipeptide
6
L S K S L G N K G Y V C T L T K E C Q K L C R
28
L S L G N K G C T L T K E C Q+ C
8
L S D Y L G N K G G W C T L T K E C Q R S C N
30
51.7%
NZ_CP034118.1 and 1 other:
NZ_CP034118.1 Lanthipeptides: EG886_RS06310_lanthipeptide
Lanthipeptides: EG886_RS06310_lanthipeptide
3
W K D L S K S L G N K G Y V C T L T K E C Q K L C R
28
W ++S L G N G C T L T K E C Q C
3
W W N I S C H L G N T G Q F C T L T K E C Q P S C N
28
51.7%
NZ_CP034118.1 and 1 other:
NZ_CP034118.1 Lanthipeptides: EG886_RS06305_lanthipeptide
Lanthipeptides: EG886_RS06305_lanthipeptide
3
W K D L S K S L G N K G Y V C T L T K E C Q K L C R
28
W ++S L G N G C T L T K E C Q C
3
W W N I S C H L G N T G R F C T L T K E C Q P N C N
28
50.0%
NZ_AKXV01000031.1 and 4 others:
NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptide NZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptide NZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide NZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide
Lanthipeptides: Y19_RS0109895_lanthipeptide
6
L S K S L G N K G Y V C T L T K E C Q K L C R
28
L S L G N+G C T L T K E C Q C
8
L S D F L G N Q G G W C T L T K E C Q P N C N
30

#### MIBiG 4.0 matches for EL241_RS01725

50.0%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
2
G W K D L S K S L G N K G Y V C T L T K E C Q K L C R
28
W ++S L G N K G C T L T E C C
2
A W Y N I S C R L G N K G A Y C T L T V E C M P S C N
28
50.0%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
5
D L S K S L G N K G Y V C T L T K E C Q K L C R
28
L S +L G N G C T L T K E C Q C
7
S L S N A L G N N G G W C T L T K E C Q P N C N
30
20.5%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
17
C T L T K E C Q K L C
27
C T L+K E C Q C
28
C T L S K E C Q P N C
38
EL241_RS13590
Leader:
MTNQKKEVMNEKEQKLEAELRELSSHEDENGG
Core:
F P W T V T V P L S I A L C P T A K C T S K C R
Core with dehydrations:
F P W Dhb V Dhb V P L Dha I A L Cys P Dhb A K Cys Dhb Dha K Cys R

#### antiSMASH-DB 4.0 matches for EL241_RS13590

100.0%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS13590_lanthipeptide
Lanthipeptides: EL241_RS13590_lanthipeptide
1
F P W T V T V P L S I A L C P T A K C T S K C R
24
F P W T V T V P L S I A L C P T A K C T S K C R
1
F P W T V T V P L S I A L C P T A K C T S K C R
24
44.8%
NZ_JADPDT010000005.1 and 1 other:
NZ_JADPDT010000005.1 Lanthipeptides: I4V19_RS09875_lanthipeptide
Lanthipeptides: I4V19_RS09875_lanthipeptide
7
V P L S I A L C P T A K C T S K C
23
V S I+L C P T K C T S K C
12
V E A S I S L C P T T K C T S K C
28
42.9%
NZ_CP017762.1 and 3 others:
NZ_CP017762.1 Lanthipeptides: BKP57_RS21840_lanthipeptide NZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptide NZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptide
Lanthipeptides: BKP57_RS21840_lanthipeptide
7
V P L S I A L C P T A K C T S K C
23
V S I A L C P T C+S K C
8
V A A S I A L C P T L A C S S K C
24
with 85 more sequence matches
Only the first 10 are displayed here.
42.9%
NZ_CP040417.1 and 7 others:
NZ_CP040417.1 Lanthipeptides: FE328_RS09035_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02890_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02890_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02830_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02830_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02865_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02865_lanthipeptide
Lanthipeptides: FE328_RS09035_lanthipeptide
3
W T V T V P L S I A L C P T A K C T S K C R
24
W T V P+S+A+C P+ K C S R
3
W T S L V P I S L A I C P S T K C A S I T R
24
41.7%
NZ_CP050134.2 and 3 others:
NZ_EQ973330.1 Lanthipeptides: CORMATOL_RS14310_lanthipeptide NZ_LR134504.1 Lanthipeptides: EL293_RS13085_lanthipeptide NZ_LR134504.1 Lanthipeptides: EL293_RS13085_lanthipeptide
Lanthipeptides: HBA49_RS00775_lanthipeptide
7
V P L S I A L C P T A K C T S K C
23
+P+S I A L C P T +C+ +C
7
I P I S I A L C P T T R C S R R C
23
41.7%
NZ_CP063142.1 and 1 other:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21460_lanthipeptide
Lanthipeptides: HPB58_RS21460_lanthipeptide
3
W T V T V P L S I A L C P T
16
W T V T+P+S+A C P T
7
W T V T I P I S L A A C P T
20
41.4%
NZ_CP042598.1 and 3 others:
NZ_CP042598.1 Lanthipeptides: FUT28_RS13815_lanthipeptide NZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11625_lanthipeptide NZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11625_lanthipeptide
Lanthipeptides: FUT28_RS13815_lanthipeptide
7
V P L S I A L C P T A K C T S K C
23
V S I+L C P T K C T S+C
12
V D A S I S L C P T T K C T S Q C
28
40.7%
NZ_LT630004.1:
Lanthipeptides: BQ5796_RS18310_lanthipeptide
5
V T V P L S I A L C P T A K C T S K C
23
+T V +S+++C P T K C T S+C
9
I T V T I S V S M C P T T K C T S Q C
27
40.6%
NZ_CP036019.1 and 1 other:
NZ_CP036019.1 Lanthipeptides: EXW52_RS27205_lanthipeptide
Lanthipeptides: EXW52_RS27205_lanthipeptide
4
T V T V P L S I A L C P T A K C T S K C
23
T+ V +S+ L C P T K C T S K C
13
T I V V A I S V G L C P T T K C T S K C
32
40.6%
NZ_NUML01000015.1:
Lanthipeptides: COD66_RS20140_lanthipeptide
4
T V T V P L S I A L C P T A K C T S K C
23
T+ V +S+ L C P T K C T S K C
13
T I V V G I S V G L C P T T K C T S K C
32
39.3%
NZ_CP039292.1 and 1 other:
NZ_CP039292.1 Lanthipeptides: E4J16_RS14990_lanthipeptide
Lanthipeptides: E4J16_RS14990_lanthipeptide
3
W T V T V P L S I A L C P T A K C T S K C R
24
W + ++ +C P T A C T S K C R
7
W P C G I G I T T T I C P T A V C T S K C R
28
38.7%
NZ_AP026714.1 and 21 others:
NZ_AP026714.1 Lanthipeptides: PO853_RS06520_lanthipeptide NZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptide NZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptide NZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptide NZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptide NZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptide NZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptide NZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptide NZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptide NZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptide NZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptide NZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptide NZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptide NZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptide NZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptide NZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptide NZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptide NZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptide NZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptide NZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptide NZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptide
Lanthipeptides: PO853_RS06520_lanthipeptide
4
T V T V P L S I A L--------C P T A K C T S K C
23
T+T+P+S I A+ C P T+ C T C
4
T I T I P I S I A V S G W I S D K T C P T S V C T R A C
31
38.5%
NZ_JFCR01000001.1 and 3 others:
NZ_JFCR01000001.1 Lanthipeptides: JQ44_RS10210_lanthipeptide NZ_JUNC01000006.1 Lanthipeptides: ADC63_RS10380_lanthipeptide NZ_JUNC01000006.1 Lanthipeptides: ADC63_RS10380_lanthipeptide
Lanthipeptides: JQ44_RS10210_lanthipeptide
10
S I A L C P T A K C T S K C
23
S+A L C P T K C+S C
13
S V A L C P T T K C S S A C
26

#### MIBiG 4.0 matches for EL241_RS13590

34.6%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
13
L C P T A K C T S K C
23
C P T K C T S K C
16
F C P T T K C T S K C
26
32.4%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
5
V T V P L S I A L C P T A K C T S K C
23
V V +S A C P T K C T S+C
19
V A V G V S A A F C P T T K C T S R C
37
16.7%
BGC0000553.3 (SSGG_RS09925):
Lanthipeptide: SRO15-2212
9
L S I A L C
14
L S+ L C
15
L S V V L C
20
EL241_RS01765
Leader:
MKKLVINLFEMFGS
Core:
L N V R Q C C F L L S D E I E I P D E L A E
Core with dehydrations:
L N V R Q Cys Cys F L L Dha D E I E I P D E L A E

#### antiSMASH-DB 4.0 matches for EL241_RS01765

100.0%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS01765_lanthipeptide
Lanthipeptides: EL241_RS01765_lanthipeptide
1
L N V R Q C C F L L S D E I E I P D E L A E
22
L N V R Q C C F L L S D E I E I P D E L A E
1
L N V R Q C C F L L S D E I E I P D E L A E
22
21.2%
NZ_LVYL01000010.1 and 1 other:
NZ_LVYL01000010.1 Lanthipeptides: A3863_RS05845_lanthipeptide
Lanthipeptides: A3863_RS05845_lanthipeptide
3
V R Q C C F L L S D E I E I P D E L A E
22
+ C F L ++ E+P+E L +
1
I N S C T F L F H E D-E V P E E L Q K
19
20.4%
NZ_CP013210.1:
Lanthipeptides: AS589_RS08105_lanthipeptide
2
N V R Q C C F L L S D E I E I P D E L A E
22
N C C+ L D I P D E A
15
N G F T C C W C L G D V I V N P D E P A S
35
with 4 more sequence matches
18.9%
NC_022571.1 and 1 other:
NZ_CP016091.1 Lanthipeptides: CLOBY_RS22135_lanthipeptide
Lanthipeptides: CLSA_RS23015_lanthipeptide
3
V R Q C C F L L S D E I E I P D E L
20
+ +C C F E +I P +L
13
M E K C C F G G I Y E T K I P I Q L
30
15.0%
NZ_CBYF010000036.1 and 1 other:
NZ_JAMBNC010000014.1 Lanthipeptides: M2T98_RS17575_lanthipeptide
Lanthipeptides: C2S54_RS14310_lanthipeptide
8
F L L S D E I E
15
++L S D E I E
16
Y I L S D E I E
23
14.0%
NZ_JAGKQT010000007.1 and 1 other:
NZ_JAGKQT010000007.1 Lanthipeptides: J2M30_RS09870_lanthipeptide
Lanthipeptides: J2M30_RS09870_lanthipeptide
3
V R Q C C F L L S D E I E I P D E L
20
+ C F L ++ E+P+E L
18
I N S C T F L F H E D-E V P E E L
34
9.1%
NZ_LT907978.1:
Lanthipeptides: allorf_2780940_2781146_lanthipeptide
5
Q C C F L L S D E I E I P D
18
+C +L L S ++ + D
24
E C L Y L L S T D V S L S D
37
allorf_0347033_0347134
Leader:
MGISSFRLYFLRNIFAI
Core:
N C S S Y I Q V F S Y Y F V L N
Core with dehydrations:
N Cys Dha Dha Y I Q V F Dha Y Y F V L N

#### antiSMASH-DB 4.0 matches for allorf_0347033_0347134

100.0%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: allorf_0347033_0347134_lanthipeptide
Lanthipeptides: allorf_0347033_0347134_lanthipeptide
1
N C S S Y I Q V F S Y Y F V L N
16
N C S S Y I Q V F S Y Y F V L N
1
N C S S Y I Q V F S Y Y F V L N
16
20.8%
NZ_CP020040.1:
Lanthipeptides: allorf_278451_278618_lanthipeptide
2
C S S Y I Q V F S Y Y F V L N
16
C S I++ +F V+
6
C S R L I R L G G I W F V I G
20

#### Lanthipeptide(s) for EL241_RS01745

EL241_RS01720
Leader:
MEKKEWEKTAQIVQEGFLQEVEEQEIGEESGGA
Core:
W W N V S K N L G N K G R I C T L T K E C Q S M C N
Core with dehydrations:
W W N V Dha K N L G N K G R I Cys Dhb L Dhb K E Cys Q Dha M Cys N

#### antiSMASH-DB 4.0 matches for EL241_RS01720

100.0%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS01720_lanthipeptide
Lanthipeptides: EL241_RS01720_lanthipeptide
1
W W N V S K N L G N K G R I C T L T K E C Q S M C N
26
W W N V S K N L G N K G R I C T L T K E C Q S M C N
1
W W N V S K N L G N K G R I C T L T K E C Q S M C N
26
65.5%
NZ_CP034118.1 and 1 other:
NZ_CP034118.1 Lanthipeptides: EG886_RS06305_lanthipeptide
Lanthipeptides: EG886_RS06305_lanthipeptide
1
W W N V S K N L G N K G R I C T L T K E C Q S M C N
26
W W N+S +L G N G R C T L T K E C Q C N
3
W W N I S C H L G N T G R F C T L T K E C Q P N C N
28
62.1%
NZ_CP034118.1 and 1 other:
NZ_CP034118.1 Lanthipeptides: EG886_RS06310_lanthipeptide
Lanthipeptides: EG886_RS06310_lanthipeptide
1
W W N V S K N L G N K G R I C T L T K E C Q S M C N
26
W W N+S +L G N G+ C T L T K E C Q C N
3
W W N I S C H L G N T G Q F C T L T K E C Q P S C N
28
with 101 more sequence matches
Only the first 10 are displayed here.
60.7%
NC_021362.1 and 29 others:
NC_021362.1 Lanthipeptides: BALI_RS00925_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide
Lanthipeptides: BALI_RS00925_lanthipeptide
1
W W N V S K N L G N K G R I C T L T K E C Q S M C
25
W+N+S L G N K G+ C T L T K E C Q C
3
W Y N I S C Q L G N K G Q W C T L T K E C Q R S C
27
60.7%
NZ_CP006058.1 and 23 others:
NZ_CP006058.1 Lanthipeptides: BAMY6639_RS13800_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptide
Lanthipeptides: BAMY6639_RS13800_lanthipeptide
1
W W N V S K N L G N K G R I C T L T K E C Q S M C N
26
W+++S L G N K G C T L T E C Q S C N
3
W Y D I S C K L G N K G A W C T L T V E C Q S S C N
28
60.7%
NZ_CP063276.1 and 1 other:
NZ_CP063276.1 Lanthipeptides: IM743_RS02795_lanthipeptide
Lanthipeptides: IM743_RS02795_lanthipeptide
1
W W N V S K N L G N K G R I C T L T K E C Q S M C N
26
W++V S L G N K G C T L T E C Q+ C N
3
W Y D V S C R L G N K G A W C T L T V E C Q N N C N
28
60.7%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS01725_lanthipeptide
Lanthipeptides: EL241_RS01725_lanthipeptide
1
W W N V S K N L G N K G R I C T L T K E C Q S M C
25
W ++S K+L G N K G +C T L T K E C Q +C
3
W K D L S K S L G N K G Y V C T L T K E C Q K L C
27
59.3%
NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide
Lanthipeptides: CWT12_RS00385_lanthipeptide
4
V S K N L G N K G R I C T L T K E C Q S M C N
26
+S+ L G N G +C T L T K E C Q M C N
5
L S R K L G N T G Y V C T L T K E C Q R M C N
27
57.1%
NZ_FOBE01000018.1:
Lanthipeptides: BMW61_RS13085_lanthipeptide
1
W W N-V S K N L G N K G R I C T L T K E C Q S M C N
26
W++ +S L G N+G C T L T K E C Q+ C N
2
W Y S E M S A A L G N R G S Y C T L T K E C Q A C C N
28
53.8%
NZ_CP050134.2 and 3 others:
NZ_EQ973330.1 Lanthipeptides: CORMATOL_RS10565_lanthipeptide NZ_LR134504.1 Lanthipeptides: EL293_RS07240_lanthipeptide NZ_LR134504.1 Lanthipeptides: EL293_RS07240_lanthipeptide
Lanthipeptides: HBA49_RS00770_lanthipeptide
4
V S K N L G N K G R I C T L T K E C Q S M C N
26
+S+ L G N G R C T+T K E C C N
1
L S R L L G N N G R W C T I T K E C M P S C N
23
53.3%
NZ_LT985747.1 and 1 other:
NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide
Lanthipeptides: C8268_RS00165_lanthipeptide
2
W N V S K N L G N K G R I C T L T K E C Q S M C N
26
+ +S L G N K G C T L T K E C Q C N
6
F T L S D Y L G N K G G W C T L T K E C Q R S C N
30
53.3%
NZ_NTSF01000026.1 and 1 other:
NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21845_lanthipeptide
Lanthipeptides: CN325_RS21845_lanthipeptide
1
W W N V S K N L G N K G R I C T L T K E C Q S M C N
26
W W N V S +L G N G+ C T +K E C C N
4
W W N V S C H L G N D G K Y C T A S K E C M P T C N
29
51.7%
NZ_NTSF01000026.1 and 1 other:
NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21835_lanthipeptide
Lanthipeptides: CN325_RS21835_lanthipeptide
1
W W N V S K N L G N K G R I C T L T K E C Q S M C
25
+W N+S +L G N G +C T L T K E C+ C
4
F W N I S C H L G N D G S V C T L T K E C R P A C
28

#### MIBiG 4.0 matches for EL241_RS01720

57.1%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
1
W W N V S K N L G N K G R I C T L T K E C Q S M C N
26
W+N+S L G N K G C T L T E C C N
3
W Y N I S C R L G N K G A Y C T L T V E C M P S C N
28
50.0%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
2
W N V S K N L G N K G R I C T L T K E C Q S M C N
26
+++S L G N G C T L T K E C Q C N
6
F S L S N A L G N N G G W C T L T K E C Q P N C N
30
23.1%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
15
C T L T K E C Q S M C N
26
C T L+K E C Q C N
28
C T L S K E C Q P N C N
39
EL241_RS01725
Leader:
MTKKEYGLQRMSQLDQRDFLKEIEEHEKQNQVSGG
Core:
W G W K D L S K S L G N K G Y V C T L T K E C Q K L C R
Core with dehydrations:
W G W K D L Dha K Dha L G N K G Y V Cys Dhb L Dhb K E Cys Q K L Cys R

#### antiSMASH-DB 4.0 matches for EL241_RS01725

100.0%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS01725_lanthipeptide
Lanthipeptides: EL241_RS01725_lanthipeptide
1
W G W K D L S K S L G N K G Y V C T L T K E C Q K L C R
28
W G W K D L S K S L G N K G Y V C T L T K E C Q K L C R
1
W G W K D L S K S L G N K G Y V C T L T K E C Q K L C R
28
60.7%
NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide
Lanthipeptides: CWT12_RS00385_lanthipeptide
6
L S K S L G N K G Y V C T L T K E C Q K L C
27
L S+ L G N G Y V C T L T K E C Q++C
5
L S R K L G N T G Y V C T L T K E C Q R M C
26
60.7%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS01720_lanthipeptide
Lanthipeptides: EL241_RS01720_lanthipeptide
3
W K D L S K S L G N K G Y V C T L T K E C Q K L C
27
W ++S K+L G N K G +C T L T K E C Q +C
1
W W N V S K N L G N K G R I C T L T K E C Q S M C
25
with 101 more sequence matches
Only the first 10 are displayed here.
60.0%
NZ_CKMQ01000043.1 and 10 others:
NZ_CKMQ01000043.1 Lanthipeptides: AE832_RS11585_lanthipeptide NZ_CKMR01000002.1 Lanthipeptides: AD782_RS11690_lanthipeptide NZ_CKMR01000002.1 Lanthipeptides: AD782_RS11690_lanthipeptide NZ_FIXU01000003.1 Lanthipeptides: A1M11_RS11670_lanthipeptide NZ_FIXU01000003.1 Lanthipeptides: A1M11_RS11670_lanthipeptide NZ_LR216041.1 Lanthipeptides: E0F00_RS05465_lanthipeptide NZ_LR216046.1 Lanthipeptides: E0E82_RS05980_lanthipeptide NZ_LR216046.1 Lanthipeptides: E0E82_RS05980_lanthipeptide NZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00170_lanthipeptide NZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00170_lanthipeptide
Lanthipeptides: AE832_RS11585_lanthipeptide
2
G W K D L S---K S L G N K G Y V C T L T K E C Q K L C R
28
G W L S ++L G N K G V C T T E C Q C R
1
G W A Q L S F I S E A L G N K G A V C T G T I E C Q N N C R
30
57.1%
NC_021362.1 and 29 others:
NC_021362.1 Lanthipeptides: BALI_RS00925_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide
Lanthipeptides: BALI_RS00925_lanthipeptide
3
W K D L S K S L G N K G Y V C T L T K E C Q K L C R
28
W ++S L G N K G C T L T K E C Q+ C+
3
W Y N I S C Q L G N K G Q W C T L T K E C Q R S C K
28
57.1%
NZ_CP006058.1 and 23 others:
NZ_CP006058.1 Lanthipeptides: BAMY6639_RS13800_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptide
Lanthipeptides: BAMY6639_RS13800_lanthipeptide
2
G W K D L S K S L G N K G Y V C T L T K E C Q K L C R
28
W D+S L G N K G C T L T E C Q C
2
A W Y D I S C K L G N K G A W C T L T V E C Q S S C N
28
57.1%
NZ_CP063276.1 and 1 other:
NZ_CP063276.1 Lanthipeptides: IM743_RS02795_lanthipeptide
Lanthipeptides: IM743_RS02795_lanthipeptide
2
G W K D L S K S L G N K G Y V C T L T K E C Q K L C R
28
W D+S L G N K G C T L T E C Q C
2
A W Y D V S C R L G N K G A W C T L T V E C Q N N C N
28
57.1%
NZ_KE384107.1:
Lanthipeptides: G586_RS23925_lanthipeptide
3
W K D L S K S L G N K G Y V C T L T K E C Q K L C R
28
+ D L S S L G N+G C T+T K E C Q C
3
Y A D L S A S L G N R G S Y C T I T K E C Q A C C N
28
53.3%
NZ_CP043317.1 and 1 other:
NZ_CP043317.1 Lanthipeptides: FYC74_RS17680_lanthipeptide
Lanthipeptides: FYC74_RS17680_lanthipeptide
6
L S K S L G N K G Y V C T L T K E C Q K L C R
28
L S S L G N G C T L T K E C Q C
8
L S D S L G N H G G W C T L T K E C Q P N C S
30
53.3%
NZ_LT985747.1 and 1 other:
NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide
Lanthipeptides: C8268_RS00165_lanthipeptide
6
L S K S L G N K G Y V C T L T K E C Q K L C R
28
L S L G N K G C T L T K E C Q+ C
8
L S D Y L G N K G G W C T L T K E C Q R S C N
30
51.7%
NZ_CP034118.1 and 1 other:
NZ_CP034118.1 Lanthipeptides: EG886_RS06310_lanthipeptide
Lanthipeptides: EG886_RS06310_lanthipeptide
3
W K D L S K S L G N K G Y V C T L T K E C Q K L C R
28
W ++S L G N G C T L T K E C Q C
3
W W N I S C H L G N T G Q F C T L T K E C Q P S C N
28
51.7%
NZ_CP034118.1 and 1 other:
NZ_CP034118.1 Lanthipeptides: EG886_RS06305_lanthipeptide
Lanthipeptides: EG886_RS06305_lanthipeptide
3
W K D L S K S L G N K G Y V C T L T K E C Q K L C R
28
W ++S L G N G C T L T K E C Q C
3
W W N I S C H L G N T G R F C T L T K E C Q P N C N
28
50.0%
NZ_AKXV01000031.1 and 4 others:
NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptide NZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptide NZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide NZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide
Lanthipeptides: Y19_RS0109895_lanthipeptide
6
L S K S L G N K G Y V C T L T K E C Q K L C R
28
L S L G N+G C T L T K E C Q C
8
L S D F L G N Q G G W C T L T K E C Q P N C N
30

#### MIBiG 4.0 matches for EL241_RS01725

50.0%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
2
G W K D L S K S L G N K G Y V C T L T K E C Q K L C R
28
W ++S L G N K G C T L T E C C
2
A W Y N I S C R L G N K G A Y C T L T V E C M P S C N
28
50.0%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
5
D L S K S L G N K G Y V C T L T K E C Q K L C R
28
L S +L G N G C T L T K E C Q C
7
S L S N A L G N N G G W C T L T K E C Q P N C N
30
20.5%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
17
C T L T K E C Q K L C
27
C T L+K E C Q C
28
C T L S K E C Q P N C
38
EL241_RS13590
Leader:
MTNQKKEVMNEKEQKLEAELRELSSHEDENGG
Core:
F P W T V T V P L S I A L C P T A K C T S K C R
Core with dehydrations:
F P W Dhb V Dhb V P L Dha I A L Cys P Dhb A K Cys Dhb Dha K Cys R

#### antiSMASH-DB 4.0 matches for EL241_RS13590

100.0%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS13590_lanthipeptide
Lanthipeptides: EL241_RS13590_lanthipeptide
1
F P W T V T V P L S I A L C P T A K C T S K C R
24
F P W T V T V P L S I A L C P T A K C T S K C R
1
F P W T V T V P L S I A L C P T A K C T S K C R
24
44.8%
NZ_JADPDT010000005.1 and 1 other:
NZ_JADPDT010000005.1 Lanthipeptides: I4V19_RS09875_lanthipeptide
Lanthipeptides: I4V19_RS09875_lanthipeptide
7
V P L S I A L C P T A K C T S K C
23
V S I+L C P T K C T S K C
12
V E A S I S L C P T T K C T S K C
28
42.9%
NZ_CP017762.1 and 3 others:
NZ_CP017762.1 Lanthipeptides: BKP57_RS21840_lanthipeptide NZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptide NZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptide
Lanthipeptides: BKP57_RS21840_lanthipeptide
7
V P L S I A L C P T A K C T S K C
23
V S I A L C P T C+S K C
8
V A A S I A L C P T L A C S S K C
24
with 85 more sequence matches
Only the first 10 are displayed here.
42.9%
NZ_CP040417.1 and 7 others:
NZ_CP040417.1 Lanthipeptides: FE328_RS09035_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02890_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02890_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02830_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02830_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02865_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02865_lanthipeptide
Lanthipeptides: FE328_RS09035_lanthipeptide
3
W T V T V P L S I A L C P T A K C T S K C R
24
W T V P+S+A+C P+ K C S R
3
W T S L V P I S L A I C P S T K C A S I T R
24
41.7%
NZ_CP050134.2 and 3 others:
NZ_EQ973330.1 Lanthipeptides: CORMATOL_RS14310_lanthipeptide NZ_LR134504.1 Lanthipeptides: EL293_RS13085_lanthipeptide NZ_LR134504.1 Lanthipeptides: EL293_RS13085_lanthipeptide
Lanthipeptides: HBA49_RS00775_lanthipeptide
7
V P L S I A L C P T A K C T S K C
23
+P+S I A L C P T +C+ +C
7
I P I S I A L C P T T R C S R R C
23
41.7%
NZ_CP063142.1 and 1 other:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21460_lanthipeptide
Lanthipeptides: HPB58_RS21460_lanthipeptide
3
W T V T V P L S I A L C P T
16
W T V T+P+S+A C P T
7
W T V T I P I S L A A C P T
20
41.4%
NZ_CP042598.1 and 3 others:
NZ_CP042598.1 Lanthipeptides: FUT28_RS13815_lanthipeptide NZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11625_lanthipeptide NZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11625_lanthipeptide
Lanthipeptides: FUT28_RS13815_lanthipeptide
7
V P L S I A L C P T A K C T S K C
23
V S I+L C P T K C T S+C
12
V D A S I S L C P T T K C T S Q C
28
40.7%
NZ_LT630004.1:
Lanthipeptides: BQ5796_RS18310_lanthipeptide
5
V T V P L S I A L C P T A K C T S K C
23
+T V +S+++C P T K C T S+C
9
I T V T I S V S M C P T T K C T S Q C
27
40.6%
NZ_CP036019.1 and 1 other:
NZ_CP036019.1 Lanthipeptides: EXW52_RS27205_lanthipeptide
Lanthipeptides: EXW52_RS27205_lanthipeptide
4
T V T V P L S I A L C P T A K C T S K C
23
T+ V +S+ L C P T K C T S K C
13
T I V V A I S V G L C P T T K C T S K C
32
40.6%
NZ_NUML01000015.1:
Lanthipeptides: COD66_RS20140_lanthipeptide
4
T V T V P L S I A L C P T A K C T S K C
23
T+ V +S+ L C P T K C T S K C
13
T I V V G I S V G L C P T T K C T S K C
32
39.3%
NZ_CP039292.1 and 1 other:
NZ_CP039292.1 Lanthipeptides: E4J16_RS14990_lanthipeptide
Lanthipeptides: E4J16_RS14990_lanthipeptide
3
W T V T V P L S I A L C P T A K C T S K C R
24
W + ++ +C P T A C T S K C R
7
W P C G I G I T T T I C P T A V C T S K C R
28
38.7%
NZ_AP026714.1 and 21 others:
NZ_AP026714.1 Lanthipeptides: PO853_RS06520_lanthipeptide NZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptide NZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptide NZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptide NZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptide NZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptide NZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptide NZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptide NZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptide NZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptide NZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptide NZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptide NZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptide NZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptide NZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptide NZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptide NZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptide NZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptide NZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptide NZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptide NZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptide
Lanthipeptides: PO853_RS06520_lanthipeptide
4
T V T V P L S I A L--------C P T A K C T S K C
23
T+T+P+S I A+ C P T+ C T C
4
T I T I P I S I A V S G W I S D K T C P T S V C T R A C
31
38.5%
NZ_JFCR01000001.1 and 3 others:
NZ_JFCR01000001.1 Lanthipeptides: JQ44_RS10210_lanthipeptide NZ_JUNC01000006.1 Lanthipeptides: ADC63_RS10380_lanthipeptide NZ_JUNC01000006.1 Lanthipeptides: ADC63_RS10380_lanthipeptide
Lanthipeptides: JQ44_RS10210_lanthipeptide
10
S I A L C P T A K C T S K C
23
S+A L C P T K C+S C
13
S V A L C P T T K C S S A C
26

#### MIBiG 4.0 matches for EL241_RS13590

34.6%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
13
L C P T A K C T S K C
23
C P T K C T S K C
16
F C P T T K C T S K C
26
32.4%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
5
V T V P L S I A L C P T A K C T S K C
23
V V +S A C P T K C T S+C
19
V A V G V S A A F C P T T K C T S R C
37
16.7%
BGC0000553.3 (SSGG_RS09925):
Lanthipeptide: SRO15-2212
9
L S I A L C
14
L S+ L C
15
L S V V L C
20
EL241_RS01765
Leader:
MKKLVINLFEMFGS
Core:
L N V R Q C C F L L S D E I E I P D E L A E
Core with dehydrations:
L N V R Q Cys Cys F L L Dha D E I E I P D E L A E

#### antiSMASH-DB 4.0 matches for EL241_RS01765

100.0%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS01765_lanthipeptide
Lanthipeptides: EL241_RS01765_lanthipeptide
1
L N V R Q C C F L L S D E I E I P D E L A E
22
L N V R Q C C F L L S D E I E I P D E L A E
1
L N V R Q C C F L L S D E I E I P D E L A E
22
21.2%
NZ_LVYL01000010.1 and 1 other:
NZ_LVYL01000010.1 Lanthipeptides: A3863_RS05845_lanthipeptide
Lanthipeptides: A3863_RS05845_lanthipeptide
3
V R Q C C F L L S D E I E I P D E L A E
22
+ C F L ++ E+P+E L +
1
I N S C T F L F H E D-E V P E E L Q K
19
20.4%
NZ_CP013210.1:
Lanthipeptides: AS589_RS08105_lanthipeptide
2
N V R Q C C F L L S D E I E I P D E L A E
22
N C C+ L D I P D E A
15
N G F T C C W C L G D V I V N P D E P A S
35
with 4 more sequence matches
18.9%
NC_022571.1 and 1 other:
NZ_CP016091.1 Lanthipeptides: CLOBY_RS22135_lanthipeptide
Lanthipeptides: CLSA_RS23015_lanthipeptide
3
V R Q C C F L L S D E I E I P D E L
20
+ +C C F E +I P +L
13
M E K C C F G G I Y E T K I P I Q L
30
15.0%
NZ_CBYF010000036.1 and 1 other:
NZ_JAMBNC010000014.1 Lanthipeptides: M2T98_RS17575_lanthipeptide
Lanthipeptides: C2S54_RS14310_lanthipeptide
8
F L L S D E I E
15
++L S D E I E
16
Y I L S D E I E
23
14.0%
NZ_JAGKQT010000007.1 and 1 other:
NZ_JAGKQT010000007.1 Lanthipeptides: J2M30_RS09870_lanthipeptide
Lanthipeptides: J2M30_RS09870_lanthipeptide
3
V R Q C C F L L S D E I E I P D E L
20
+ C F L ++ E+P+E L
18
I N S C T F L F H E D-E V P E E L
34
9.1%
NZ_LT907978.1:
Lanthipeptides: allorf_2780940_2781146_lanthipeptide
5
Q C C F L L S D E I E I P D
18
+C +L L S ++ + D
24
E C L Y L L S T D V S L S D
37
allorf_0347033_0347134
Leader:
MGISSFRLYFLRNIFAI
Core:
N C S S Y I Q V F S Y Y F V L N
Core with dehydrations:
N Cys Dha Dha Y I Q V F Dha Y Y F V L N

#### antiSMASH-DB 4.0 matches for allorf_0347033_0347134

100.0%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: allorf_0347033_0347134_lanthipeptide
Lanthipeptides: allorf_0347033_0347134_lanthipeptide
1
N C S S Y I Q V F S Y Y F V L N
16
N C S S Y I Q V F S Y Y F V L N
1
N C S S Y I Q V F S Y Y F V L N
16
20.8%
NZ_CP020040.1:
Lanthipeptides: allorf_278451_278618_lanthipeptide
2
C S S Y I Q V F S Y Y F V L N
16
C S I++ +F V+
6
C S R L I R L G G I W F V I G
20

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.57 out of 26.33
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.05 out of 21.55
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.32 out of 21.55
Confidence: medium
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 23.92 out of 29.65
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.59 out of 24.78
Confidence: medium
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.97 out of 26.85
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.84 out of 24.78
Confidence: medium
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 15.96 out of 18.16
Confidence: strong
Additional weak hits (3):
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.85 out of 39.62
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.53 out of 33.73
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.16 out of 29.25
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

EL241_RS01720 - Class II
  Cleavage pHMM score: -3.70
  RODEO score: 0
  Monoisotopic mass: 2940.4 Da
  Molecular weight: 2942.4 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2960.4 Da N = 1
EL241_RS01725 - Class II
  Cleavage pHMM score: -3.40
  RODEO score: 0
  Monoisotopic mass: 3171.6 Da
  Molecular weight: 3173.7 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3191.7 Da N = 1
EL241_RS13590 - Class II
  Cleavage pHMM score: -3.70
  RODEO score: 0
  Monoisotopic mass: 2513.4 Da
  Molecular weight: 2515.0 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2533.1 Da N = 1
    2551.1 Da N = 2
    2569.1 Da N = 3
EL241_RS01765 - Class II
  Cleavage pHMM score: -3.80
  RODEO score: 0
  Monoisotopic mass: 2530.2 Da
  Molecular weight: 2531.9 Da
  Number of bridges: 1
allorf_0347033_0347134 - Class II
  Cleavage pHMM score: -7.00
  RODEO score: 0
  Monoisotopic mass: 1891.9 Da
  Molecular weight: 1893.1 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1911.1 Da N = 1
    1929.1 Da N = 2
EL241_RS01720 - Class II
  Cleavage pHMM score: -3.70
  RODEO score: 0
  Monoisotopic mass: 2940.4 Da
  Molecular weight: 2942.4 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2960.4 Da N = 1
EL241_RS01725 - Class II
  Cleavage pHMM score: -3.40
  RODEO score: 0
  Monoisotopic mass: 3171.6 Da
  Molecular weight: 3173.7 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3191.7 Da N = 1
EL241_RS13590 - Class II
  Cleavage pHMM score: -3.70
  RODEO score: 0
  Monoisotopic mass: 2513.4 Da
  Molecular weight: 2515.0 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2533.1 Da N = 1
    2551.1 Da N = 2
    2569.1 Da N = 3
EL241_RS01765 - Class II
  Cleavage pHMM score: -3.80
  RODEO score: 0
  Monoisotopic mass: 2530.2 Da
  Molecular weight: 2531.9 Da
  Number of bridges: 1
allorf_0347033_0347134 - Class II
  Cleavage pHMM score: -7.00
  RODEO score: 0
  Monoisotopic mass: 1891.9 Da
  Molecular weight: 1893.1 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1911.1 Da N = 1
    1929.1 Da N = 2

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
AbrC3 | Antibiotic production activator
ArcA | Repressor of carbon oxidation
LexA variant 1 | Repressor of DNA damage response
LexA variant 2 | Repressor of DNA damage response
MexT | Global virulence regulator
RutR | Regulator of the pyrimidine and purine metabolism

NZ_LR134483.1 - Region 3 - HR-T2PKS,T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,121,293 - 1,175,732 nt. (total: 54,440 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
HR-T2PKS: (hr-t2pks-ksa and (t2fas or APE_KS2 or ketoacyl-synt))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase reductase
EL241_RS05410: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

EL241_RS05510: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

EL241_RS13795: hydroxymethylglutaryl-CoA reductase

smcogs
  SMCOG1187: hydroxymethylglutaryl-CoA reductase

Transferases: PPTase acetyltransferase phosphorylase
EL241_RS05395: thiamine-phosphate pyrophosphorylase

smcogs
  SMCOG1280: thiamine-phosphate pyrophosphorylase

EL241_RS13790: acetyl-CoA acetyltransferase

smcogs
  SMCOG1124: acetyl-CoA acetyltransferase

EL241_RS13915: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

EL241_RS13920: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: peptidase
EL241_RS05555: methionine aminopeptidase

smcogs
  SMCOG1172: methionine aminopeptidase

Ligases: synthase
EL241_RS05440: hydroxymethylglutaryl-CoA synthase

smcogs
  SMCOG1043: hydroxymethylglutaryl-CoA synthase

EL241_RS05500: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | HR-T2PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0002276.2 |  |  | 0.49 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0000866.5 |  |  | 0.46 | other (other) | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0000867.3 |  |  | 0.39 | other (other) | polyhydroxyalkanoic acids | Ectothiorhodospira shaposhnikovii
BGC0001197.5 |  |  | 0.36 | PKS | frankiamicin | Frankia sp. EAN1pec
BGC0001987.2 |  |  | 0.35 | PKS | koreenceine A, koreenceine B, koreenceine C, koreenceine D | Pseudomonas koreensis
BGC0000888.5 |  |  | 0.34 | other (other) | bacilysin | Bacillus sp. CS93
BGC0002510.2 |  |  | 0.33 | PKS | youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4 | Streptomyces sp.
BGC0000231.5 |  |  | 0.32 | PKS | griseusin A, griseusin B | Streptomyces griseus
BGC0001184.4 |  |  | 0.31 | other (other) | bacilysin | Bacillus velezensis FZB42
BGC0000218.5 |  |  | 0.30 | PKS | doxorubicin | Streptomyces peucetius

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002276.2 |  | 0.58 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0000866.5 |  | 0.57 | other (other) | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0000867.3 |  | 0.52 | other (other) | polyhydroxyalkanoic acids | Ectothiorhodospira shaposhnikovii
BGC0001197.5 |  | 0.50 | PKS | frankiamicin | Frankia sp. EAN1pec
BGC0002510.2 |  | 0.49 | PKS | youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4 | Streptomyces sp.
BGC0001928.2 |  | 0.49 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0001987.2 |  | 0.49 | PKS | koreenceine A, koreenceine B, koreenceine C, koreenceine D | Pseudomonas koreensis
BGC0000888.5 |  | 0.48 | other (other) | bacilysin | Bacillus sp. CS93
BGC0000231.5 |  | 0.46 | PKS | griseusin A, griseusin B | Streptomyces griseus
BGC0001917.4 |  | 0.46 | PKS | 5aTHQ-9i, 5aTHQ-9n, 5aTHQ-10a, STAMs-9i, STAMs-9n | Streptomyces nigrescens

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 24.52 out of 29.25
Confidence: medium
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 18.25 out of 18.46
Confidence: strong
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.82 out of 21.84
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.93 out of 30.25
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.38 out of 26.06
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.78 out of 18.16
Confidence: strong
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.32 out of 23.79
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.53 out of 28.19
Confidence: medium
Additional weak hits (6):
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 27.38 out of 39.62
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.26 out of 28.14
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.39 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.63 out of 32.74
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.54 out of 29.38
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
ColR | Phenol-responsive regulator
IolR | Regulator of the inositol catabolism
MexT | Global virulence regulator
MogR | Repressor of flagellar motility genes
RpoN | Regulator of nitrogen assimilation and virulence
SypG | Regulator of biofilm formation and host colonization
ZuR variant 1 | Zinc-responsive repressor

NZ_LR134483.1 - Region 4 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,289,853 - 1,310,734 nt. (total: 20,882 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
EL241_RS06370: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: carboxylase
EL241_RS06310: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Hydrolases: peptidase
EL241_RS06295: methionine aminopeptidase

smcogs
  SMCOG1172: methionine aminopeptidase

Ligases: synthase synthetase
EL241_RS06340: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

EL241_RS06350: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

EL241_RS06380: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001535.3 |  | 0.69 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0001534.3 |  | 0.64 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0001736.3 |  | 0.44 | NRPS | pepteridine A, pepteridine B | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001594.3 |  | 0.43 | other (other) | fischerindole L | Fischerella muscicola UTEX 1829
BGC0000668.5 |  | 0.43 | other (other), terpene | 12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole | Hapalosiphon welwitschii UTEX B 1830
BGC0002284.3 |  | 0.42 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001535.3 |  | 0.69 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0001534.3 |  | 0.64 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0001736.3 |  | 0.44 | NRPS | pepteridine A, pepteridine B | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001594.3 |  | 0.43 | other (other) | fischerindole L | Fischerella muscicola UTEX 1829
BGC0000668.5 |  | 0.43 | other (other), terpene | 12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole | Hapalosiphon welwitschii UTEX B 1830
BGC0002284.3 |  | 0.42 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
EL241_RS06340: PT_FPPS_like
Domain 1 (32 - 293): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  DMAPP, IPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.13 out of 27.78
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.06 out of 26.06
Confidence: medium
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.83 out of 26.33
Confidence: medium
Additional weak hits (4):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.67 out of 26.06
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.12 out of 31.73
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.49 out of 29.65
Confidence: weak
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.50 out of 29.72
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes

NZ_LR134483.1 - Region 5 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,588,819 - 1,609,667 nt. (total: 20,849 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase phosphate reductase
EL241_RS07710: N-acetyl-gamma-glutamyl-phosphate reductase

smcogs
  SMCOG1219: N-acetyl-gamma-glutamyl-phosphate reductase

EL241_RS07755: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

Transferases: aminotransferase
EL241_RS07725: aminotransferase class V

smcogs
  SMCOG1139: aminotransferase class V

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000647.3 |  | 0.75 | terpene | carotenoid | Rhodobacter sphaeroides
BGC0000645.3 |  | 0.49 | terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0000646.5 |  | 0.49 | terpene | β-carotein | uncultured bacterium
BGC0000656.5 |  | 0.47 | terpene | zeaxanthin | Xanthobacter autotrophicus Py2
BGC0000648.3 |  | 0.44 | terpene | carotenoid | Myxococcus xanthus
BGC0000558.5 |  | 0.42 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000664.5 |  | 0.42 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000638.3 |  | 0.42 | terpene | carotenoid | Pantoea ananatis
BGC0001456.3 |  | 0.42 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000630.3 |  | 0.41 | terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000647.3 |  | 0.75 | terpene | carotenoid | Rhodobacter sphaeroides
BGC0000645.3 |  | 0.49 | terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0000646.5 |  | 0.49 | terpene | β-carotein | uncultured bacterium
BGC0000656.5 |  | 0.47 | terpene | zeaxanthin | Xanthobacter autotrophicus Py2
BGC0000648.3 |  | 0.44 | terpene | carotenoid | Myxococcus xanthus
BGC0000558.5 |  | 0.42 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000664.5 |  | 0.42 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000638.3 |  | 0.42 | terpene | carotenoid | Pantoea ananatis
BGC0001456.3 |  | 0.42 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000630.3 |  | 0.41 | terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene | C30 carotenoid | diapophytoene | C30 | acyclic | none

Genes with terpene domains:
EL241_RS07750: PT_phytoene_like
Domain 1 (5 - 280): Prenyltransferase; Phytoene synthase like
Subtype: Diapophytoene synthase

Reactions:
  FPP → diapophytoene

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.25 out of 20.47
Confidence: medium
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.50 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.87 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.03 out of 28.19
Confidence: medium
Additional weak hits (6):
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.46 out of 39.62
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.92 out of 26.06
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.75 out of 29.38
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.04 out of 28.14
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.03 out of 31.73
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
FPP | Farnesyl diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ToxT | Regulator of MSHA biosynthesis
VqsM | Regulator of quorum-sensing signalling systems
ZuR variant 1 | Zinc-responsive repressor