LOCUS       NZ_LR134479            21134 bp    DNA     circular CON 23-AUG-2024
DEFINITION  Rothia aeria strain NCTC10207 chromosome 1, complete sequence.
ACCESSION   NZ_LR134479
VERSION     NZ_LR134479.1
KEYWORDS    RefSeq.
SOURCE      Rothia aeria
  ORGANISM  Rothia aeria
            Bacteria; Actinomycetota; Actinomycetes; Micrococcales;
            Micrococcaceae; Rothia.
REFERENCE   1  (bases 1 to 2707814)
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (18-DEC-2018) WTSI, Pathogen Informatics, Wellcome Trust
            Sanger Institute, CB10 1SA, United Kingdom
COMMENT     ##Taxonomic-Update-Statistics-START##
            This Genome (query)               :: GCA_900637985.1
            Current Name                      :: Rothia aeria
            Previous Name                     :: Rothia dentocariosa
            Date Updated                      :: 2020-07-31
            Analysis Type :: Average Nucleotide Identity (ANI)
            Analysis 1 (A1) :: Query vs. TYPE genome for current name
            A1 Genome (subject)               :: GCA_002355935.1
            A1 Name                           :: Rothia aeria
            A1 ANI                            :: 97.49%
            A1 Query Coverage                 :: 89.17%
            A1 Subject Coverage               :: 93.28%
            Analysis 2 (A2) :: Query vs. TYPE genome for previous name
            A2 Genome (subject)               :: GCA_900455895.1
            A2 Name                           :: Rothia dentocariosa
            A2 ANI                            :: 90.02%
            A2 Query Coverage                 :: 26.56%
            A2 Subject Coverage               :: 28.88%
            ##Taxonomic-Update-Statistics-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/13/2024 02:12:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,382
            CDSs (total)                      :: 2,321
            Genes (coding)                    :: 2,312
            CDSs (with protein)               :: 2,312
            Genes (RNA)                       :: 61
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 48
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 9
            CDSs (without protein)            :: 9
            Pseudo Genes (ambiguous residues) :: 0 of 9
            Pseudo Genes (frameshifted)       :: 2 of 9
            Pseudo Genes (incomplete)         :: 8 of 9
            Pseudo Genes (internal stop)      :: 0 of 9
            Pseudo Genes (multiple problems)  :: 1 of 9
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:04:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 867369
            Orig. end                         :: 888503
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LR134479.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            The organism was changed from 'Rothia dentocariosa' to 'Rothia
            aeria' in July  2020.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21134
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="2"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21134
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21134
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11134](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11134)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            97..417
                     /locus_tag="EL250_RS03775"
                     /old_locus_tag="NCTC10207_00774"
     CDS             97..417
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012584.4"
                     /locus_tag="EL250_RS03775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10207_00774"
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein subunit"
                     /protein_id="WP_006888857.1"
                     /transl_table=11
                     /translation="MKEPQKVKDFFMPQNSNSPQHPNEHTLHSNQDDLGPTIVCAPFAG
                     YLTLLVGQGEHVDAGQKLAIVEALKVETLVTARTHGRVGRITHTDGSYVTGGQLLLTIV
                     PE"
     gene            538..1974
                     /locus_tag="EL250_RS03780"
                     /old_locus_tag="NCTC10207_00775"
     CDS             538..1974
                     /EC_number="1.8.1.15"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004004371.1"
                     /locus_tag="EL250_RS03780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10207_00775"
                     /product="mycothione reductase"
                     /protein_id="WP_006888907.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.7e-39, bitscore:
                     132.9, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIKDLEVIDGVAQYDLVVIGSGSGNSIIGPEWDDKTVAIIDGGI
                     FGGTCLNVGCIPTKMFVYPATVAVKTQEVAELGVEASVQNISWQNMRDRIFPHRIDKIS
                     EAGRQWRANLPNVDFYPEYAHFTGRHTLQTASGRKVHGKQVVIAAGSRATRPDVPGINL
                     PQVLTNDTVMRMEHLPQRMVVLGGGVVAAEFAHVFSALGVEVTQANRSARLLRGVDEEV
                     VNRFAQAASQQWNLLLEHALIEIRQNDDDSVTVVLENDGELVDVVADKVLVATGRRPNS
                     DSLHAEKFFDVDARGLIGVDEYQRVLYNGAPVEGVFALGDISSPYQLKHVANHEARIVQ
                     HNLSHPNELRASDHRFVPAAVFSHPQLAYVGLTEEQARAAGEREGFEVTVKSQEFGDTA
                     YGWAMEDKVGLCKLIARKDTGQLLGAALVGEESSVLIQPLIQAMSFGLGVREMARGQYW
                     IHPALTEVVENALLGLEINA"
     gene            complement(2137..4215)
                     /locus_tag="EL250_RS03785"
                     /old_locus_tag="NCTC10207_00776"
     CDS             complement(2137..4215)
                     /NRPS_PKS="Domain: AMP-binding (36-469). E-value: 1.3e-86.
                     Score: 282.7. Matches aSDomain:
                     nrpspksdomains_EL250_RS03785_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888843.1"
                     /locus_tag="EL250_RS03785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10207_00776"
                     /product="long-chain fatty acid--CoA ligase"
                     /protein_id="WP_126499822.1"
                     /sec_met_domain="AMP-binding (E-value: 6.1e-87, bitscore:
                     289.0, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVFSVPAEVMCDPQLNITSILERRCADTTNPLLYRWQMSPGNWQ
                     PVRAREFRAMVVAVAKGLIASGIVPGDRISIMSRTRFEWTLIDFAIWYAGAVSVPVYET
                     SAPAQAAWALSHSEAKAVFVEDDKLAGVIEQANSIEPLHLENTWVINNGALDALITAGL
                     NVPEEAVYTARDTATCSSLATIVYTSGTTGRPKGCPLTHGHFLNLSVNTKLAEPEIANP
                     HNSSIIFLPLAHVLARLIQILAMDAGVQIGHSPNIKNLAADLDSFKPTMLLVVPRVFEK
                     IYEGAKAKAAKGGTLNKALFDRSVKVAVEWSRAKISGRVPLALAAQYTFYDRLVYAKLR
                     AAMGGQLKYAVSGGGPLSDTLGHFFHAVGIRVVEGYGLTETCAPIAAGRISEFQIGTIG
                     PLLPGAQGRIAEDGELQVRGVGVIDGYYKNPQEDATAFTEDGWFKTGDLARFDERGNLT
                     IVGRKKEIIVTAGGKNVVPSVAEDHIRTSPLVSQAMLVGDQKPFIAALVTLDPDTLPEQ
                     LEHLGLPRAMSIPEAAVHPKVREAVQMFIDEANLLVSRAEAVREFRIMNKDLTEADGYL
                     TPSQKLKRSKILKDFSAYVDDMYSRVSGDMSVRLERLQEIKEQASEKLHEYAEQASERI
                     EELREQASERLQGYQAARAQKTESTEQVEATAVTSDGPKDTAVIEAAEDDTSRSHEQ"
     aSDomain        complement(2809..4107)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EL250_RS03785_AMP-binding.1"
                     /evalue="1.30E-86"
                     /label="EL250_RS03785_AMP-binding.1"
                     /locus_tag="EL250_RS03785"
                     /protein_end="469"
                     /protein_start="36"
                     /score="282.7"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="WQMSPGNWQPVRAREFRAMVVAVAKGLIASGIVPGDRISIMSRTR
                     FEWTLIDFAIWYAGAVSVPVYETSAPAQAAWALSHSEAKAVFVEDDKLAGVIEQANSIE
                     PLHLENTWVINNGALDALITAGLNVPEEAVYTARDTATCSSLATIVYTSGTTGRPKGCP
                     LTHGHFLNLSVNTKLAEPEIANPHNSSIIFLPLAHVLARLIQILAMDAGVQIGHSPNIK
                     NLAADLDSFKPTMLLVVPRVFEKIYEGAKAKAAKGGTLNKALFDRSVKVAVEWSRAKIS
                     GRVPLALAAQYTFYDRLVYAKLRAAMGGQLKYAVSGGGPLSDTLGHFFHAVGIRVVEGY
                     GLTETCAPIAAGRISEFQIGTIGPLLPGAQGRIAEDGELQVRGVGVIDGYYKNPQEDAT
                     AFTEDGWFKTGDLARFDERGNLTIVGRKKEIIVT"
     CDS_motif       complement(2905..2979)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EL250_RS03785_0002"
                     /evalue="1.20E-05"
                     /label="NRPS-A_a6"
                     /locus_tag="EL250_RS03785"
                     /protein_end="437"
                     /protein_start="412"
                     /score="17.8"
                     /tool="antismash"
                     /translation="GELQVRGVGVIDGYYKNPQEDATAF"
     CDS_motif       complement(3610..3669)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EL250_RS03785_0001"
                     /evalue="2.10E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="EL250_RS03785"
                     /protein_end="202"
                     /protein_start="182"
                     /score="23.3"
                     /tool="antismash"
                     /translation="ATIVYTSGTTGRPKGCPLTH"
     gene            complement(4235..5074)
                     /locus_tag="EL250_RS03790"
                     /old_locus_tag="NCTC10207_00777"
     CDS             complement(4235..5074)
                     /NRPS_PKS="Domain: Abhydrolase_1 (53-154). E-value:
                     1.5e-14. Score: 46.2. Matches aSDomain:
                     nrpspksdomains_EL250_RS03790_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888837.1"
                     /locus_tag="EL250_RS03790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10207_00777"
                     /product="carboxylesterase"
                     /protein_id="WP_126499823.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 3.2e-14, bitscore:
                     51.2, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 1.2e-09, bitscore: 35.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIFENSLEPVRRIRRKVHERQQTGGVPAQQPDFNHEPLSSPADP
                     KKYAGDLGILIVHGFTGSPHSLHPLAAYLAEKGYPVELPRLPGHGTHWRDMAVTHYTDW
                     IDSVEQAYERLTGAGYRVIVIGMSMGGCLAAHLAARRPVAGTVLINPFFVDVNPLMRIA
                     HRVAPVLPVMRSIGSDIAVPGVDEGAYARTPTASIRQLHLLGVETRELLPKLHAPVLYL
                     RSVSDHTVTDASHRYFLQHVSASVEFKWLTRSYHVATLDYDAELVKEFTHKFVQSLS"
     aSDomain        complement(4613..4915)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EL250_RS03790_Abhydrolase_1.1"
                     /evalue="1.50E-14"
                     /label="EL250_RS03790_Abhydrolase_1.1"
                     /locus_tag="EL250_RS03790"
                     /protein_end="154"
                     /protein_start="53"
                     /score="46.2"
                     /tool="antismash"
                     /translation="ILIVHGFTGSPHSLHPLAAYLAEKGYPVELPRLPGHGTHWRDMAV
                     THYTDWIDSVEQAYERLTGAGYRVIVIGMSMGGCLAAHLAARRPVAGTVLINPFFV"
     gene            5351..6112
                     /locus_tag="EL250_RS03795"
                     /old_locus_tag="NCTC10207_00778"
     CDS             5351..6112
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1141: acyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004004374.1"
                     /locus_tag="EL250_RS03795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10207_00778"
                     /product="1-acyl-sn-glycerol-3-phosphate acyltransferase"
                     /protein_id="WP_006888851.1"
                     /transl_table=11
                     /translation="MVTHPATTPVYAVLKAISDPTVRRIWPHEVIGAENMPNGPAIIAS
                     NHLAFCDSVFIPLAVKPTVNFLAKSDYFTTPGFKGRAMAAFFRSVGQLPMDRSGGEKSR
                     ASLEAGLKVLRAGGVLGIYPEGTRSPDGRYYRPKIGVARLALESGAPVVPVGQLGTDLI
                     QPAGTNRPRFRHNGKPITVRTIIGKPLEFAHLQDKANDHATLRAVTDQIAEAIRALSGQ
                     QYVPVPADKVKRLMAAHGWSAQTAVASLLTH"
     misc_feature    complement(6156..6169)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.03"
                     /tool="antismash"
     gene            6301..7689
                     /locus_tag="EL250_RS03800"
                     /old_locus_tag="NCTC10207_00779"
     CDS             6301..7689
                     /EC_number="2.5.1.54"
                     /GO_function="GO:0003849 - 3-deoxy-7-phosphoheptulonate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888865.1"
                     /locus_tag="EL250_RS03800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10207_00779"
                     /product="class II 3-deoxy-7-phosphoheptulonate synthase"
                     /protein_id="WP_126499824.1"
                     /transl_table=11
                     /translation="MSNTIRPQQPSDHGLDIWRTLNADQQPTWADHPDYAPTVAELEKL
                     PPLVFAGEVDSMRRQLAEVAEGRAFLLQGGDCAETFAGATADKISGRVRTILQMAAVLT
                     YGASMPVVKMGRIAGQFSKPRSSDVETRDGVTLPSFRGETVNGHEFTAEARTHDPKRML
                     RGYHTSSATLNLVRAFTKGGFADLRSVHQWNRGFTENPAHARYEETAREIGRALKFMEA
                     CGVDFNALTTTDLYVGHEALVLDFERALTRIDSRTHQPYDTSAHFLWIGERTRGINDAH
                     VDFLSKVRNPIGVKLGPSTTTDDALALIDKLDPEREPGRLTFITRMGAKNIREKLPALV
                     EGVNASGAKVVWVTDPMHGNTISVPSGIKTRRFDDILDEVRGFFEVHESLGSFPGGIHV
                     EMTGDDVTECLGGSDPVDEAALANRYESLCDPRLNHSQSLEIAFLVSEYLKSQYVRQLG
                     NTMR"
     gene            complement(7775..9328)
                     /locus_tag="EL250_RS03805"
                     /old_locus_tag="NCTC10207_00780"
     CDS             complement(7775..9328)
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012298.4"
                     /locus_tag="EL250_RS03805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10207_00780"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_126499825.1"
                     /sec_met_domain="Pkinase (E-value: 1.7e-44, bitscore:
                     149.2, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMNPPPSSTPSSSPASSATRGRDWLNGIIFDEHYLAGPLIAGGGM
                     AEVYYATDTWLNDSPVAIKILKPELAASPENQRKFYSEESSLRQMGGGHVIGVLSSGEQ
                     TVRGQKLRYIVMEYVHGCTLGQLLRERGALSVGEALQILLPVVEGLSEAHARRLVHSDI
                     KPGNILLDVTETVKLADFGLTRRDDQALTGEIMGTPAYAAPELVKGQQTGAPADIFALG
                     VMMYLMFAGHLPFDGIANSSEVHRYNANVEIPPVAEAAPGLDPGLAGLISWCTRQQPED
                     RPENALEVLTDLRDVTAHMSEEELAWRTPLVEEPEVPLWEAVEHIAETTGLAQMVHNSP
                     ISGIGRAEDLLVGTNRRAQAAKPVLPMEEYVPLSIGIGPETRPVNPALARGDIPLGGQR
                     SLDGSSARMHYGALRPELAQRSPNNVFGLPRTPPGPNRSPQRRPASHPQARPGPRPFPR
                     NRRLPAERLGPPPSPFTVVTGVVVLLVALVLAGFVGWLLAQSVLQSTWWANLSQMFGGL
                     "
     gene            9521..9889
                     /locus_tag="EL250_RS03810"
                     /old_locus_tag="NCTC10207_00781"
     CDS             9521..9889
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013398832.1"
                     /locus_tag="EL250_RS03810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10207_00781"
                     /product="Rv2175c family DNA-binding protein"
                     /protein_id="WP_006888853.1"
                     /transl_table=11
                     /translation="MSSEKTVQTFALVGDWVTIPDIAEALDLKVTRVHNLISDGTLVAL
                     REPDTNVRKVPALFLNGDHVLESLKGTLVVLKDAGFSDEEAITWLYTADDSLPGRPIDA
                     LINGQKTEIRRRAQALAW"
     misc_feature    complement(9561..9573)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.41"
                     /tool="antismash"
     gene            complement(10001..11134)
                     /locus_tag="EL250_RS03815"
                     /old_locus_tag="NCTC10207_00782"
     CDS             complement(10001..11134)
                     /EC_number="2.5.1.-"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888910.1"
                     /locus_tag="EL250_RS03815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10207_00782"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_126499826.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 2.9e-38, bitscore:
                     128.7, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQSAFETQIQAEQQAYLQEVEAEMARFFTQQREMLSNISPDAL
                     SLLAAIEALSTGGKRLRALLSYWGWRGAGGVSILEDPKPLSVVRIGVAIELFQSAALIH
                     DDIIDRSDTRRGAPAVHKRFENQHKSSAWRGDTFNYGLTGGIIAGDLCLSWSETMFART
                     GVGSLPNRTARTVFDTMRTEVMAGQYLDVLSEVIDSEDYDAALQRAQNVIRYKSAKYSC
                     EHPLTLGGALALDAQQNQHHPILNAYRSFGLPLGEGFQLRDDQLGVFGEPETTGKPAGD
                     DIREGKRTVLVALTEKNADQAGRSLLETCLGNPNLDVHDVQRVRGLMLSCGAVAQLEEL
                     IARKSAAIDTALAALPVPEQVREALEAIAAKALHRAA"
     misc_feature    11170..11186
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 21.87"
                     /tool="antismash"
     misc_feature    complement(11175..11195)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 24.65"
                     /tool="antismash"
     misc_feature    11233..11242
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 16.04"
                     /tool="antismash"
     misc_feature    11237..11250
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 18.44"
                     /tool="antismash"
     misc_feature    complement(11250..11268)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 25.59"
                     /tool="antismash"
     misc_feature    11253..11271
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 21.44"
                     /tool="antismash"
     gene            11359..12696
                     /gene="dinB"
                     /locus_tag="EL250_RS03820"
                     /old_locus_tag="NCTC10207_00783"
     CDS             11359..12696
                     /EC_number="2.7.7.7"
                     /GO_function="GO:0003684 - damaged DNA binding [Evidence
                     IEA]"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /gene="dinB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888896.1"
                     /locus_tag="EL250_RS03820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10207_00783"
                     /product="DNA polymerase IV"
                     /protein_id="WP_186335921.1"
                     /transl_table=11
                     /translation="MSENVKNVFNTSRFQRGNTADDRSEKPRIMMHLDMDAFFVNVELL
                     NKPELHGTPIIVAHEGPRSVVCSASYEARDSGVQSGMPLARAKRLSPQATILPLRGDYG
                     FYSRAVMRILRDESPLVEQVSVDEAFIDLTGATAIGGSPVAIAQRVRERIANELSLPCS
                     AGISINKFLAKMASTGSKPNGLWVVPPHRVQEFLDPMPVNKLWGVGARSATLLNEYGIY
                     TVAQLREFDAQWLCGRFGNAAGNHLYALARGIDHRPVVTERVEKSMGAEHTFAADTRCV
                     ADIERAVQGIALRLGRRLRAAGKTAGALTIKYRYEGFETHTKSIPLTEPVDSGMQIYRI
                     ACAALRAMGLLIKSRDGQKEQASRALRLIGVRAERLQQCASGVQQTLFTLDPQEGDGAE
                     KADWGRVERVLDGIHTRFSAEAVRPASLMGYTAGRTHMHRVQHRQV"
     gene            13007..13405
                     /locus_tag="EL250_RS03825"
                     /old_locus_tag="NCTC10207_00784"
     CDS             13007..13405
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888833.1"
                     /locus_tag="EL250_RS03825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10207_00784"
                     /product="DUF3040 domain-containing protein"
                     /protein_id="WP_023134584.1"
                     /transl_table=11
                     /translation="MALSEREQKVLDQLEELMHAEDPQFASSMSSTGNTAPVFSARHMV
                     LGILCVLAGLGIIIGAVASKIILLGIVGFIVAAGGVYFATTSKKTPIDSFLGGKAKGAS
                     AEKAQQQRKQSKLMERLEERWDEREQGR"
     misc_feature    complement(13928..13942)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 18.83"
                     /tool="antismash"
     gene            14031..14459
                     /gene="mraZ"
                     /locus_tag="EL250_RS03830"
                     /old_locus_tag="NCTC10207_00785"
     CDS             14031..14459
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0051302 - regulation of cell division
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mraZ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005507741.1"
                     /locus_tag="EL250_RS03830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10207_00785"
                     /product="division/cell wall cluster transcriptional
                     repressor MraZ"
                     /protein_id="WP_006888897.1"
                     /transl_table=11
                     /translation="MFLGTYSPRLDTKGRIILPAKFREELSAGLVLTRGQERCLYVFSA
                     EEFERIHEQMRSAPLSSRQARDYMRVFLSGASDEVPDKQGRVTIPAALREYARLDRELV
                     VIGAGSRAEIWDAQAWDEYLARTEAEFAQLDEEPFPFL"
     gene            14527..15579
                     /gene="rsmH"
                     /locus_tag="EL250_RS03835"
                     /old_locus_tag="NCTC10207_00786"
     CDS             14527..15579
                     /EC_number="2.1.1.199"
                     /GO_function="GO:0016434 - rRNA (cytosine)
                     methyltransferase activity [Evidence IEA]"
                     /codon_start=1
                     /gene="rsmH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888919.1"
                     /locus_tag="EL250_RS03835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10207_00786"
                     /product="16S rRNA (cytosine(1402)-N(4))-methyltransferase
                     RsmH"
                     /protein_id="WP_126499827.1"
                     /transl_table=11
                     /translation="MSAKESTHAGAQGAVAPAHTLTLTETPDAALSKKEAKERHVPVML
                     TRCLDLLAPALEREGAVVIDGTLGMGGHTEAMLERFPELQVIGIDRDPQAHTIAGQRLE
                     RFGERFIPVHAVYDQIEYAMDVAGVNAVDGVLFDLGVSSMQLDERSRGFAYSYDAPLDM
                     RMNSEDELTARTVVNEYPLERLRRIIRTWGEEKFAARIAEQIVAQRAVQPFETTGELVA
                     AIQKAVPAAAQRKGGHPAKRTFQALRIEVNHELEALEHAVPVAIDSLSLGGRFVAMSYH
                     SLEDKIVKRGLSAAATSKAPKGFPVELDEHKPTMKVITRGAEPPTEAEIAENSRAASAK
                     LRAGEKIRVT"
     gene            15580..16680
                     /locus_tag="EL250_RS03840"
                     /old_locus_tag="NCTC10207_00787"
     CDS             15580..16680
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EL250_RS03840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NCTC10207_00787"
                     /product="hypothetical protein"
                     /protein_id="WP_126499828.1"
                     /transl_table=11
                     /translation="MSVTTKTTMTGERRNTPKPPGRKTRPEGTAAAPGRAGSSHPGSAR
                     RASTTSTNTRRTAQKEKVGASSRAATAGSTTRTSTPSRARTTETARPQGAGATRTSRGA
                     TLLDAPARFLAYTRGVAGVFEKPSTAQFEANTTSVRPKPARGGTAGRAEVREASGAKKR
                     APLARSLRKPTRRGGIMSLLMWAVFLVIPLFLIFNLLMNILVAQRQYELVDMHAQELAL
                     TQQNEALHQELGYNEAPQDLAIRASLLNMFPSTTPATLDVQNGTIQGTPTPAASPTSAN
                     GTRGNLVPAPATRDNDPSGQKAADAQKQAQEKTAKQNREREEKEKQEKEKASAAASPSP
                     SASPQGSQSPQQAQPSQAAPSASANR"
     gene            16854..18701
                     /locus_tag="EL250_RS03845"
                     /old_locus_tag="NCTC10207_00788"
     CDS             16854..18701
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008658 - penicillin binding [Evidence
                     IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888847.1"
                     /locus_tag="EL250_RS03845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10207_00788"
                     /product="penicillin-binding protein 2"
                     /protein_id="WP_126499829.1"
                     /transl_table=11
                     /translation="MAHKKKAVSSQNERKLSRRGFMIGASSTGLLGLLSLRLLYVQGLD
                     PQNLAATSRDSRTRTQKVPAVRGQITDVNGHVLARSVQRYNIIADQTIVAEFKRYDHSQ
                     ERVTVTPTELVYEVTDILRTVDPTITDDFVKSKLEGDSRYSVIKTNVTPEIYNRIDALG
                     APFLFGEVISERLYPDGPVGGSVVGRYRIVDEAVEGKENETVERNLSVGIERTFEKELA
                     GVNGKRVYEIGADGVRIPVTQEQVSESVNGKTVRLTLNRDIQYYAQQVMKARVDELKAE
                     WGCAIVMDVRDGSILALADSTTMDPGAEKVENAQDMVPRAISQIIEPGSTEKILTASAL
                     IEKGITTPTDTYDVPATLTVNGQTFKDAFEHPAQRRTFSGIITDSMNTGTVLVGQKMPK
                     EERYEWLKKYGMGEFTGIDIAGEQQGLVSDWKTWDGRQEFTVFFGQGLAQTPLQTAMVF
                     QAVGNLGVKVKPRIVDAIIDPDGTEHKVPVEGAQRVVSEKTARDCLTLMENVVTKGQAK
                     LAQVNGYRVGGKTGTAEAPSEKGGYEGYTTSFIGVAPIENPRFMVSITLQRPKGEVGTI
                     GGTGQFSQIMERVLHTYNIPHSTTEPHIIPIFADGKNSG"
     gene            18825..20567
                     /locus_tag="EL250_RS03850"
                     /old_locus_tag="NCTC10207_00789"
     CDS             18825..20567
                     /EC_number="6.3.2.13"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016874 - ligase activity [Evidence IEA]"
                     /GO_process="GO:0008360 - regulation of cell shape
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /GO_process="GO:0051301 - cell division [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006888886.1"
                     /locus_tag="EL250_RS03850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10207_00789"
                     /product="UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,
                     6-diaminopimelate ligase"
                     /protein_id="WP_126499830.1"
                     /transl_table=11
                     /translation="MNGEQPGEKLSDEAMPGEELFGKDAQNLRPRLTTGYPLDTLIQKL
                     QNLEAQPRLALSGSRNVTGISMDSRSVREGDLYVALPGAKTHGASFAAAAVAAGAAGIL
                     TDAQGQCIIAEAHLDLADTALIIGTDLRRVLGSLAAFIYGSNDYPQLQRFAVTGTNGKT
                     TTTYMLESVFRAALGVKTGLVGTIQILIDGVSIPSAMTTPESVHVHALLSLMGQRGVRC
                     AAMEVSSHAIDYRRVDGVRYAMSGFTNLTQDHLDLHGGMEEYFDSKAQLFTPERTERAV
                     ITADDSWGQRMLVHAQQQLGAQNTIRLLTNHGAGLESVPADFGANDWAVTEVTAQGLGH
                     TFVLANGAGERVQARTGLPADFNVSNAALAALMAWLSTSEEEREPLAAALASGEALTPV
                     VPGRMQLIGHSPHTIVDFAHNPDGLIRALEAMDRPGEGRVIIVFGATGERDQGKRPIMG
                     EIAARYADIVIVTDDDPHGEDPAPIREAVAAGAQQAIAAGARAHEVHNIAPRARAIAQA
                     IDMATPDDAVLIAGRGHETAQDVAGVDVQLDDRIEVARAMVTRGFEILPDYRRMLEENA
                     EDKK"
ORIGIN
        1 cctatccatt actggcccga tgaggaagcc gtggacccgg caacccgttt cacccgcctg
       61 ctcacggggc ttgtcgccgc cctgtagccg ttggatatga aagagccgca gaaagtaaag
      121 gacttcttca tgccgcagaa cagcaactcg ccgcagcacc caaacgaaca tactctacac
      181 tcaaaccagg atgatctggg gcccactata gtgtgtgcac cgttcgccgg gtacctgact
      241 ctgctcgtgg gtcagggcga acatgtggac gcgggacaga agctcgctat cgtcgaagcc
      301 cttaaagtgg aaactctggt aacggctcgg acgcacggtc gggttgggcg tattacccac
      361 accgatggct catacgtaac tggcgggcag ctgctactga ctatagtgcc ggaataaaac
      421 ctaagtcccc gtgttatagc taccgttaga atgatacgaa gggcacctga ggcccaagaa
      481 actggcaaac ctgagaaccg gcaggcccgg accaccacat gataaaggta ggagcgcatg
      541 agcattaaag acctcgaagt cattgacggg gtggcacagt acgaccttgt agtgatcggc
      601 tctgggtcgg gcaatagcat tattggaccc gagtgggatg ataagacagt cgccattatt
      661 gacggcggta tatttggcgg cacctgccta aatgtggggt gtatccccac aaaaatgttt
      721 gtgtatccgg ccactgtggc agttaaaacg caagaagttg ctgagcttgg cgttgaagca
      781 tccgtgcaaa acatttcgtg gcagaacatg cgcgaccgca ttttcccaca ccgaatcgat
      841 aagatttctg aggctggccg ccaatggcgt gctaacctgc cgaacgttga cttctaccca
      901 gagtatgcgc actttaccgg ccggcacacc ctgcagactg catcgggccg gaaggtccac
      961 ggtaagcagg tggttatcgc cgccggttca cgcgccacgc gccccgacgt gcccggaatt
     1021 aacctgccgc aggtgctcac aaatgatacc gtgatgcgca tggaacacct accgcagcgt
     1081 atggtggtgc ttggcggcgg ggtagtggcc gcagagttcg cacatgtttt ctcagcgctg
     1141 ggcgttgagg taacccaggc gaaccggtca gcccgcctgc tgcgcggcgt ggatgaggag
     1201 gttgtgaacc gtttcgccca agccgcatct caacagtgga atctgctgct ggagcacgct
     1261 ctcatcgaga tccgtcaaaa cgatgacgac tcagtaaccg tggttcttga gaacgacggc
     1321 gaactagttg atgtggttgc cgataaggtg ctggtggcta ccgggcggcg tccaaatagt
     1381 gatagcctgc atgctgagaa gttctttgat gtagatgccc gcggccttat tggtgtggac
     1441 gagtatcagc gggtactgta caacggcgcc cccgttgaag gcgtttttgc gctgggggat
     1501 atctcctccc catatcagct taaacatgtt gctaaccacg aggcgcgcat cgtgcagcat
     1561 aacctgtccc acccgaacga gctacgcgcc agcgaccacc gctttgtgcc cgcggctgtg
     1621 ttcagccacc cgcagctggc gtatgtgggc ctcaccgagg agcaagcgcg tgccgccggt
     1681 gaacgtgaag gctttgaggt gaccgttaaa agccaggagt ttggggatac cgcctatggc
     1741 tgggcgatgg aggataaagt ggggctgtgc aagctgatcg cccgtaaaga caccggtcag
     1801 ctgctggggg cggcgctggt gggcgaggag tcatccgtgc tcattcagcc gctcattcaa
     1861 gcgatgagct tcgggctggg ggtgcgcgag atggcccgcg gccagtactg gattcacccc
     1921 gcactgaccg aagttgttga gaacgccctg ctggggcttg aaatcaacgc atagctatag
     1981 ctgcaaaata tgccgtaggg caagttttcc cggttcgagg agaatcggtg ggaaagcctg
     2041 ccctgcggca tatatctctt gggaaacata cgtttggcag ccgtcagcgc acatcgcgta
     2101 catgcggcac ccgaccgttc cggcccaagg ccgaacttat tgctcgtggg agcgagaagt
     2161 gtcatcctct gctgcttcga tcacagcggt atccttgggg ccgtcagagg tcacagcagt
     2221 cgcctcaacc tgctcggtac tttcggtttt ctgtgctcgc gcagcctgat acccctgcag
     2281 cctctcacta gcctgttccc tgagctcctc aatgcgttcg ctggcctgct ccgcatattc
     2341 gtgcagtttc tcggacgcct gctcttttat ctcctgcagc cgctctagac gcacactcat
     2401 atcgccggag acccggctgt acatatcgtc cacatatgcg gagaaatctt tcagaatctt
     2461 tgagcgttta agcttctgag atggcgtcag gtaaccgtcg gcttccgtca ggtctttgtt
     2521 catgatgcga aattcacgca ctgcctctgc ccgagacacc agcaggtttg cctcgtcaat
     2581 aaacatctgc actgcctcac gcaccttcgg gtgcaccgct gcctcgggga tgctcatggc
     2641 acgcggtaat cccaggtgct ccagctgctc cggcagcgtg tccgggtcaa gcgtcaccag
     2701 tgcggcaata aacggttttt ggtctcccac cagcattgcc tgagatacca agggggaggt
     2761 gcggatgtga tcttccgcca cggacggtac cacattctta ccgcccgcag tcacaataat
     2821 ttctttcttg cggcccacaa ttgtcaggtt gccgcgttca tcaaagcggg ccaggtcccc
     2881 ggttttaaac cagccgtctt cagtaaatgc ggtggcgtct tcctgagggt tcttatagta
     2941 tccatcaatc acacccacgc cgcgcacctg cagttcaccg tcttcggcaa tacgcccctg
     3001 cgctcccggt aagagcgggc cgatggtccc gatctggaac tcgctaatac gccccgctgc
     3061 aatcggcgcg caagtctccg tgagaccgta cccttcaacc acccggatac ctacagcgtg
     3121 gaagaagtgg cctagagtat cggataacgg gccaccgccc gagacggcgt actttagctg
     3181 cccgcccatc gccgctcgca gcttcgcgta cacgagccta tcgtagaacg tgtactgggc
     3241 cgccaacgcg aggggaaccc gcccggaaat tttagcgcgc gaccactcaa cagcaacctt
     3301 cactgagcgg tcaaataggg ctttgttgag cgttccgcct ttagctgctt tagccttcgc
     3361 cccctcatag attttctcaa acacgcgggg cactaccagc agcatagtcg gtttaaaact
     3421 gtccagatcg gcagcgaggt ttttaatatt gggggagtgc ccaatctgta cgcccgcgtc
     3481 catcgccaat atctgaatca gcctggcgag cacatgcgcc aacggcagaa aaataataga
     3541 ggaattatgg ggattcgcaa tctctggttc cgccagtttg gtgtttacgc tcaggttcag
     3601 gaaatgcccg tgtgttagcg ggcacccctt cggcctgccg gtggtacctg aggtgtacac
     3661 aatagttgcc agggagctgc aggtggcggt gtcacgtgcc gtatacactg cttcttccgg
     3721 cacgttgagc ccggccgtaa tgagtgcatc cagggccccg ttattaataa cccaggtgtt
     3781 ttcaaggtgc aacggctcaa tgctgtttgc ctgttcgata acaccagcca gcttatcgtc
     3841 ctcaacgaaa actgctttcg cttcggagtg agaaagagcc cacgccgcct gggcgggcgc
     3901 gctcgtctca tacacgggaa cagagacggc tcccgcatac cagatagcga agtcaatgag
     3961 agtccattcg aaccgggtgc ggctcataat gctgatacga tctccgggaa caataccgga
     4021 ggcgatcagc cctttagcca ccgccaccac catggcccga aattcgcggg cccgcaccgg
     4081 ctgccaattc cccggtgaca tctgccagcg atacaacaac gggttggtag tgtcagcgca
     4141 acggcgttct aagatgctgg tgatattcag ctgcgggtcg cacattacct ctgctggaac
     4201 agagaaaacc ttcatgagtt acgccttcca cgccctagct taaggactgt acaaatttgt
     4261 gtgtgaattc tttaacaagc tcggcatcgt aatcaagggt cgccacatgg tagctacggg
     4321 tgagccattt aaattctacc gatgccgaga catgttgcag aaaatagcgg tgtgacgcgt
     4381 cagtaacggt gtggtctgat acggagcgca agtacagtac aggtgcatgc agttttggca
     4441 gtagctcgcg ggtttctacc cccagcaggt gcagctgccg gatagacgcg gtgggagtgc
     4501 gtgcatatgc cccttcatct acacccggca cggcaatatc ggaccctatt gagcgcatta
     4561 ccggcagcac tggtgccacc cggtgggcaa tgcgcatgag cgggttgaca tcaacaaaga
     4621 acgggttaat aagcactgtg ccagcaaccg ggcggcgtgc cgcaaggtgc gcggcaaggc
     4681 atccacccat agacataccg ataacaatta ctcgatatcc cgcaccagtg agccgctcgt
     4741 acgcctgctc aacactatct atccaatcgg tgtagtgggt gactgccata tcacgccagt
     4801 gagttccgtg gccgggtaag cggggtaact ccaccgggta ccctttctct gctaaatacg
     4861 ctgctaacgg gtgcagactg tgcggagagc ctgtgaaccc gtgcacgatg aggataccta
     4921 agtcacccgc atactttttg gggtctgcgg gggatgacag cggttcgtgg ttaaagtccg
     4981 gctgctgcgc aggcacccca cctgtctgtt gcctctcgtg tactttgcgg cgtatccgac
     5041 gcaccggctc taacgagttc tcaaaaatat tcatacatcc cccaggaagc tgtgtaaccc
     5101 cacacttaat atctagcact attattgctt tcaaggtgag ataaaaactc acgctattga
     5161 gctgtgagcg tgatttcgtg cgattcacag gtaactggca ggtgaaaatg ggctgtataa
     5221 cacccaatgg accccctggt acccggctac aatctactag gaaggcactc gcccctccga
     5281 tgacgcacac cggtgtgaat taatcgaacc gtgccgcgtt caataaccgg aaacactcca
     5341 ggagaaaact gtggtcacac accccgccac aacacccgta tatgcggtac ttaaagcaat
     5401 aagcgacccc actgtccggc ggatctggcc gcatgaagtc ataggtgctg aaaacatgcc
     5461 caatggtcca gccattattg ccagtaacca cttagccttc tgcgattcgg tgtttattcc
     5521 gcttgcggtt aaacccaccg taaatttctt agcgaaaagc gactatttca ctacccccgg
     5581 ctttaaaggg cgtgcaatgg cagctttctt ccgcagcgtg ggccagcttc ctatggatcg
     5641 ttcgggtggg gagaaaagca gggcttcttt agaagcgggt ctaaaggtac ttcgtgcagg
     5701 gggagtgctc ggcatctacc ctgaaggaac ccgcagtcct gacggacgct actaccgccc
     5761 taaaattggg gtggcgcgtc ttgcattgga atctggtgcg cccgtggtac ctgtgggtca
     5821 gctgggcacc gacctaatac agccagccgg gacgaacagg ccacgttttc ggcataatgg
     5881 gaaacccatt acggtacgca ctattattgg taaaccgttg gagttcgcgc atttgcagga
     5941 taaagctaat gaccacgcca cgctcagggc tgtgaccgat cagatagctg aggctattcg
     6001 cgccctctcg gggcagcagt acgtgcctgt gcccgccgac aaagttaaac ggcttatggc
     6061 ggctcatggg tggagcgccc aaaccgcagt agctagtctt ctcacacact aacagccaca
     6121 tttcggttgt acgggccgct ttgtggcgtg tgatttcacg cagcgagata aaaacatgac
     6181 cgctccgtac cgtcttgccc atagcgggag tacaataacg tagtactgcc tcatggtttt
     6241 agctatgggg taccgcaacc gcagacaacc caacctgagt gatagagcga gacaacatac
     6301 atgagcaaca cgattcgccc gcaacagccc agcgaccatg ggctggatat ttggcgcacc
     6361 cttaacgctg accagcagcc tacctgggcg gatcatcccg actacgcgcc cacagtggca
     6421 gaactcgaaa agctgccccc gctggtcttt gcgggggaag tagactcgat gcgccgtcaa
     6481 cttgctgaag tcgctgaagg tcgtgctttt ctgcttcagg gcggagactg cgccgaaacg
     6541 ttcgcgggag ccaccgccga taaaatttca ggccgtgttc gcaccatcct acagatggca
     6601 gcggtgctga cctatggggc ctctatgcct gtggttaaga tgggccgcat tgccgggcag
     6661 ttctctaaac cccgctcctc ggatgtggaa acccgtgacg gtgttaccct gccttcgttc
     6721 cgtggagaaa ccgttaacgg tcatgagttc acagcagagg cgcgcactca cgaccccaag
     6781 cggatgctgc gcgggtacca cacctcctca gcaaccctga acctggtgcg ggctttcacg
     6841 aagggcggtt ttgccgatct gcgttccgta caccagtgga accgcgggtt taccgaaaac
     6901 cctgcgcatg cccgctatga agaaactgcg cgtgaaatag gccgtgccct caaatttatg
     6961 gaagcctgcg gggtggactt taacgcattg accaccaccg acctgtacgt gggccacgag
     7021 gcactggtgc ttgattttga acgtgccctc acacgcatcg attcgcgtac ccaccaaccg
     7081 tatgacacgt ccgcacactt tttgtggatt ggcgaacgca cccgaggaat taacgacgcc
     7141 cacgtagact tcctctctaa ggtgcgtaac cccatcggtg ttaagctggg ccccagcacc
     7201 accaccgatg acgcactagc tcttatcgac aagctcgacc ctgaacggga gcccggtcgt
     7261 cttactttta tcacccgcat gggggcaaag aacattcgtg aaaaacttcc cgctctcgtt
     7321 gagggggtta atgcatccgg ggcgaaggtc gtgtgggtta ccgaccccat gcacggcaac
     7381 actatatcgg ttccatcggg gattaaaacc cgccggtttg acgatatcct ggatgaggtg
     7441 cgcggcttct ttgaggtgca tgagtccctg ggctctttcc ccggtggcat ccacgttgaa
     7501 atgactgggg atgacgtcac cgagtgtttg ggcggctcag accccgtgga tgaggcagca
     7561 ctggctaacc gctacgaatc gctgtgcgac ccgcggctga accattcaca gtctctggag
     7621 atcgcattct tggtatctga gtacctgaag agccagtacg tgcgccaatt gggtaatact
     7681 atgcgttaag cacacccaca taacgtatga tgaggccgat gagccgtcct aaagagggca
     7741 gcccatcggc cttgaacgta tgaggtgtgg gggattagag cccaccaaac atttgtgaca
     7801 ggttagccca ccacgtgctc tgtaataccg actgggccag cagccacccc acgaaccctg
     7861 ccaaaactag ggccaccaag agtacgacca ctcccgtcac tactgtaaac ggcgatggtg
     7921 gcggacctag ccgttcagcc gggagcctcc tgttacgggg gaaaggacgc gggccgggcc
     7981 gcgcttgcgg atgcgatgct ggcctgcgct gtggggaacg gttagggccc ggtggggtgc
     8041 gtggaagtcc aaagacatta ttcggggaac gctgagcaag ctctgggcgc agcgcgccat
     8101 aatgcatccg cgccgaggaa ccgtccaagg accgctgacc gcccagaggg atatcgccac
     8161 gcgctaaagc agggtttacc ggccgggttt cagggccgat accgatcgag agcggaacgt
     8221 attcttccat gggtagcaca ggttttgcgg cctgggcccg ccggttagtg cccaccagca
     8281 gatcctcagc acggccaata ccactgatgg ggctgttgtg caccatctgg gccaaccccg
     8341 tagtctcagc gatgtgttcc acagcctccc atagcggaac ttcaggttcc tccacgaggg
     8401 gagtgcgcca ggcaagctct tcctcgctca tgtgggccgt cacatcccgc agatcggtta
     8461 gaacttcaag cgcgttctct ggacggtctt caggctgctg acgggtacac cagctaatga
     8521 gccccgcaag ccctggatct aggccgggag cagcctccgc gacgggcggg atttcgacgt
     8581 ttgcattgta acggtgaacc tcgctgctgt tggcgatgcc atcaaacggc agatgcccgg
     8641 cgaacatgag gtacatcatc acgcccaagg caaaaatatc ggcgggtgca cccgtctgct
     8701 ggcctttgac cagttccggt gcggcgtatg cgggggtgcc cataatctca ccggtgagcg
     8761 cctggtcgtc gcggcgcgtc aacccgaagt ctgccagttt caccgtctcg gtcacatcca
     8821 acaaaatatt gccgggttta atatcgctgt gtaccagccg tcgcgcatga gcctcagaca
     8881 gtccctccac taccggcagt agaatttgca gggcttcccc cacagatagg gcaccgcgct
     8941 cccgcagcag ctggcctaga gtacacccgt gcacgtactc catgacaatg taccgtagct
     9001 tctgcccgcg taccgtctgt tcacctgagg aaagcacgcc gatcacatgt ccgccgccca
     9061 tctgccgtag cgatgactct tcactgtaaa acttgcgctg attctcgggt gaagcggcaa
     9121 gttcaggttt cagaatttta atagccaccg gggaatcgtt gagccatgtg tcggtcgcgt
     9181 agtacacttc ggccataccg ccgccagcaa tgagcgggcc agccaagtag tgttcatcga
     9241 agatgatgcc gtttaaccag tcacgccccc gcgtcgcaga actcgcgggg gaagaagacg
     9301 gtgttgaaga tgggggagga ttcatcatct acgattctag gggatatgtg gtgtccatgc
     9361 cgcatggaca actctcactg agcaaagata cagcggattc ataggtaaag agggtaaaac
     9421 cggccaagta atagagcccg gaccacacac cataacagaa ccggcaataa tggcggcgca
     9481 taagtaggca aaattgggta gattctggca ctcttaaaag gtgagtagcg aaaaaactgt
     9541 acagaccttt gcccttgtag gtgactgggt cactattccc gatattgccg aggcacttga
     9601 tttgaaagtt actcgagtgc acaaccttat ctcagatggc actcttgtag ccctgcgcga
     9661 accagacacg aatgtgcgta aagtacccgc gctttttctc aacggcgatc atgtgctcga
     9721 atctctcaaa ggcaccttag tagtgctcaa agacgctggt tttagcgacg aggaagccat
     9781 cacctggctc tacactgcgg atgattctct gccgggacgt cccattgatg cgctcattaa
     9841 cgggcagaag acggaaatcc gccgccgcgc acaggcctta gcctggtaaa acccaagtcc
     9901 gataaaaccg cgcgccgttg agtacttggg cgctttcctc aaactagtga cggtggaggg
     9961 gccacccgca tgatggagta gtcccctcca ccttttacag ttacgcggct cgatgcagcg
    10021 cttttgctgc gatagcttct aaggcttccc gtacctgctc cggtaccggt aaagcagcca
    10081 gcgccgtatc aatggcagca gacttgcggg caatgagctc ctcaagctgc gccactgcac
    10141 cacaagaaag catgagacca cgcacccgct gaacatcgtg aacatctagg ttcgggttcc
    10201 ccaagcatgt ctcaagcagg gaccgtcccg cctgatccgc attcttttcc gtaagtgcca
    10261 ccagcacggt gcgttttcct tcccgaatat catccccggc aggttttcca gtggtttcag
    10321 gctcaccgaa cacccccagc tgatcatcac gcagctgaaa gccttcaccc aagggtaagc
    10381 cgaagctgcg gtacgcatta agaatggggt ggtgctggtt ctgctgtgca tcaagggcta
    10441 gagcgccgcc aagagtcagc gggtgctcgc atgaatattt ggctgactta taacggatca
    10501 cgttctgggc acgctgtagt gccgcatcat aatcttcgga atcgatgact tccgagagca
    10561 catccaggta ttgcccggcc atgacttcgg tgcgcatcgt atcgaaaaca gttcgtgcgg
    10621 tgcggtttgg tagggagcct acccccgtgc gcgcgaacat tgtctccgac cacgataggc
    10681 acagatctcc ggcgataata ccccccgtaa gaccatagtt aaaagtatcg ccgcgccagg
    10741 cactactttt atgctggttc tcaaaacgct tgtgcacagc gggtgctcca cgccgagtat
    10801 cggaacggtc aataatatcg tcgtggatga gcgcagcgga ttgaaacagt tcaatggcca
    10861 cccctatacg caccaccgac aggggctttg ggtcctcaag aatactcacc ccacctgcgc
    10921 cgcgccatcc ccagtagctc agtagcgcac gcagcctttt accacctgtg gagagcgctt
    10981 caatggctgc taacaggctg agtgcatctg gtgaaatatt ggagagcatc tcgcgctgtt
    11041 gggtaaaaaa acgcgccatt tcggcctcaa cctcttgcag atatgcctgc tgttcggcct
    11101 gaatttgcgt ttcaaacgcg ctctgcgtag ccattgttgc tcccgtcgat atatatctgg
    11161 cggtggtcga tacccatcta gcttatgcta tctcccataa ttcgcggtat tttcgcgtgg
    11221 ggctagccaa ctcgattttt tatagaacaa gaatactata tagaatatat atgctattat
    11281 ggggtggtgg gaggctaaag atacatcaaa gctgaggcac aatagtcatc cagggcctcc
    11341 ctctatacag ggggtggaat gtctgagaac gtaaaaaatg tctttaatac atctcgcttc
    11401 cagcggggga ataccgctga tgaccgaagc gagaagcccc gcatcatgat gcatcttgat
    11461 atggacgcat tttttgtcaa cgtagagctg ctgaataaac cagaattaca cggaactcct
    11521 attattgtgg cgcatgaggg cccgcgctca gtggtatgtt ctgcttccta tgaggctcga
    11581 gactcgggtg ttcagtcggg tatgccgctg gcacgtgcta aacgcctgag cccacaggca
    11641 actattctgc ctctgcgggg tgattacggc ttttactctc gtgcggtcat gcgaatactg
    11701 cgggatgaaa gcccgcttgt ggaacaagta agtgttgatg aggcattcat tgatctcacc
    11761 ggtgccactg ccatcggcgg atccccggtt gcgatagcac agcgggtgcg agaacgtatt
    11821 gcaaacgagc tgtctctacc ctgctcggcg gggatatcta ttaataagtt tcttgccaaa
    11881 atggcctcaa ctggcagtaa acccaatggg ctgtgggtgg tgccacccca cagggtgcag
    11941 gagttcctgg atcctatgcc ggttaataaa ctgtggggtg tgggggcgcg aagcgccact
    12001 ttgctgaacg aatacggaat ctacacggtg gcacagctgc gtgaatttga cgcccagtgg
    12061 ctgtgcgggc gttttggtaa tgcggcaggg aaccatctct atgctcttgc tcgtggtatt
    12121 gatcatcgtc cggtggtcac tgaacgtgtt gagaaaagta tgggagctga acataccttt
    12181 gctgccgata ctcgctgcgt cgcagatatt gagcgagcgg tgcagggtat tgctttacgg
    12241 ttggggcggc ggctgcgcgc agcagggaaa accgctggtg cgctgaccat taaatatcgt
    12301 tatgaaggtt ttgagacaca cactaaatct atacccctaa ctgagcctgt agattctggg
    12361 atgcagatat atcgtattgc ttgcgccgcc ctgagggcga tggggctttt gatcaaaagt
    12421 cgcgatggtc aaaaggagca agcgtcacgg gctttacggt tgataggggt acgcgccgag
    12481 cggctgcaac aatgcgcctc tggtgtgcag cagacgcttt ttaccttgga cccacaggaa
    12541 ggggacggtg cggagaaagc tgactggggt cgtgtggagc gtgtccttga cggcatccat
    12601 acgcgattta gtgcagaggc ggtgcgcccg gcttctctga tggggtatac ggcggggcga
    12661 acacatatgc acagggtgca gcatcgtcag gtgtaaggca ggatgcgagg cgtagaagtg
    12721 cgagctttta aagaatatac ggcttagaaa tcccctgagt gttaagcgtt gaggcaggtt
    12781 catgggccgc tgggtactct gatgcatccg cggcaacgca gggatgtggt gagtgcggct
    12841 tttattctca gtacatacac agagatttag ctcaagaaag agtacctatt gggggcctaa
    12901 aaggggtact atgatgaacg tacgctaggc tacatgtgat ggtcttgccc cggggtggat
    12961 atgtgccgac ggcagggctt ttgggcacgg ttttaaggag aatgctatgg cactttcgga
    13021 gcgcgaacag aaagtccttg atcagcttga ggagttaatg cacgccgaag acccgcagtt
    13081 tgcaagttcg atgtcttcga cgggcaatac cgcgcccgta tttagcgccc gccacatggt
    13141 gctgggtatc ctgtgcgtgc ttgctgggct gggcattatt attggggcgg ttgcctcaaa
    13201 gattattctg cttggtattg tcggcttcat agttgccgcc gggggcgtgt attttgcgac
    13261 caccagtaag aaaaccccta ttgattcgtt cttaggtggt aaggctaaag gtgcctccgc
    13321 tgagaaggcg cagcaacagc gcaaacaatc gaagctcatg gagcgcctgg aagagcgctg
    13381 ggatgagcgc gaacaggggc gttagtatat ttttcttctt gtgatacgtc agtgctggcg
    13441 tgaggtacca ccgtggtaat aggctggtac gtttaaaccg tgttctacct cagacttggt
    13501 gatggggcgg ggcttcccta agggaggccc cgccccactg tccgttaaag gccgctgtac
    13561 ttgcagctac tgtacacgcc acaccggggt ggtggtacta agagccggta tttatcccaa
    13621 gctagcgtta gcttctgatt atgggtgttt tccccaccgt aagcggtact cacgctgaaa
    13681 ctgaggatgt ttcctccact tttccctcca caatcctcca ccgccccaca ataacccgtg
    13741 tagcggtggg attgtgtctg ctgccgccaa taactctaaa actgcctgcg tggaacgggt
    13801 aatgatgtgg tttttcaaaa tatgttggct attcgtgcgt cgaatcagcg ggtggcgaac
    13861 tcctcaataa cggtcctatc tggggtgaag ctgcgggatt caagggcttg acgtgcaggt
    13921 ttattaaaat ttgcgggaaa atttgggtgc ttaaaaaggg ttaagtggtg gaaagtgggg
    13981 taaagtggag ggtagcagat tgttcaagtg cgctgtgagg gggtgggtac gtgtttttag
    14041 ggacgtattc gcctcggtta gacaccaaag ggcgcatcat tcttcccgcg aaatttcgtg
    14101 aggaactttc tgctggtcta gtgctcaccc gcggacagga acgttgcttg tacgtgttct
    14161 ctgcggaaga gtttgagcgt attcacgagc agatgcgttc agcgccactg tcttcacggc
    14221 aggctcggga ctacatgcgt gtgttcctgt cgggcgcatc tgatgaggtg cccgataagc
    14281 aggggcgggt caccatcccg gcggcgttgc gtgagtatgc tcggttagac cgcgagcttg
    14341 tcgtcatcgg cgcgggttcc cgagccgaaa tctgggacgc tcaggcttgg gacgagtacc
    14401 ttgctcgtac cgaagctgaa tttgcacaac tggatgagga gcctttcccc ttcctgtaaa
    14461 ccaccccatc tgttagcgca ttcgctgcgg gagcagatcc tagtacgtga ccctcaagga
    14521 gcgaatatga gcgctaagga aagcacccac gccggtgctc agggagcggt agctcccgca
    14581 cacaccctta cgcttactga aactcccgat gcggcgcttt cgaagaaaga agcgaaagaa
    14641 cgccacgtac cggtcatgct taccaggtgc cttgacctgc tagccccggc cctcgaacgt
    14701 gaaggggcag tggtcattga tgggacttta ggaatgggcg ggcacaccga ggcaatgctt
    14761 gaacgtttcc ccgaactgca ggtgatcggt atcgaccgag acccacaggc gcacactatt
    14821 gcggggcagc ggctggagcg gttcggcgag cggttcatcc ccgtgcacgc tgtgtacgac
    14881 cagattgaat acgccatgga cgtcgccggg gtgaatgccg tcgatggcgt cctattcgac
    14941 ttgggtgtct cctccatgca gctggatgag cgttcacgcg ggtttgctta ttcttacgac
    15001 gctccgctcg atatgcggat gaatagtgaa gatgagctga cagcacgcac cgtagtgaac
    15061 gagtatccgt tggagcggct gcggagaatt atccgaacgt ggggcgaaga gaagttcgcc
    15121 gcgcggattg ccgaacagat cgttgctcag cgggccgttc agccgtttga gaccaccggt
    15181 gagctggtag ccgctatcca aaaggcggtg ccagcagcgg cacaacgcaa gggcgggcac
    15241 cctgcgaaac gcactttcca ggcactacgc attgaggtga accacgaact ggaggcactg
    15301 gaacacgctg tgccggtcgc aatcgactcg ctctccctgg gcgggcggtt cgtggccatg
    15361 agctaccaca gtttagaaga caagatcgtc aagcggggcc tgagtgctgc cgccacctct
    15421 aaggcgccca aagggttccc cgtggagctt gacgaacata agccaacgat gaaagttatc
    15481 acgcgtggcg cagagccacc gactgaggct gaaatcgcag agaattcacg cgccgcaagc
    15541 gcaaaattgc gggctggcga gaagattagg gttacataaa tgagcgtaac aacgaagacc
    15601 accatgacgg gggagcgtag gaacacgccc aaacccccgg gtcgtaaaac acgcccggaa
    15661 gggacagctg ctgcgccggg ccgagcaggc tcctcacacc ccgggtcggc tcgtcgcgcc
    15721 tccacaactt cgacaaacac ccgccgcacc gcacagaagg aaaaagttgg tgcatcatct
    15781 cgggctgcta ccgctggcag caccacccga accagcaccc ccagccgggc tcgaacaacc
    15841 gaaacagccc ggcctcaggg cgctggtgcc acgcgcacct cacggggggc gaccctgcta
    15901 gacgctcctg cccgtttctt ggcgtacacg cgcggggtag cgggagtatt tgagaagccc
    15961 tcaaccgcac agttcgaagc gaataccacc tcggtgcggc ctaaacctgc tcggggcggt
    16021 acagctgggc gcgctgaagt gcgcgaagcc tccggtgcaa aaaaacgtgc gccgctggcc
    16081 cgttctttac gtaaacccac ccgccgggga ggcatcatga gccttctgat gtgggcggtg
    16141 tttttggtga tcccgctatt tctcatcttt aacctactga tgaatatcct agtggctcag
    16201 cgtcagtacg aactggtaga catgcacgcc caggagctgg ctctcaccca gcagaacgag
    16261 gctctgcatc aggagctggg gtacaacgaa gctccgcagg atctagcgat ccgtgcttct
    16321 ctgctgaata tgttccccag caccactccg gcaactttgg acgtgcagaa cggtacgatt
    16381 cagggcaccc caaccccagc tgcttcgccc acctcagcta atgggacccg cgggaatctg
    16441 gtgccagcac ccgcgacccg cgataatgac ccctccgggc agaaggctgc ggatgcccag
    16501 aagcaggcgc aggagaaaac cgcgaagcag aaccgtgagc gggaagagaa agagaagcag
    16561 gaaaaggaga aggcaagtgc cgccgcctcg ccttcaccct ctgcatctcc gcagggttca
    16621 cagagcccgc agcaggctca gccgtcacag gctgcgccta gcgcctccgc gaatcgctaa
    16681 tacagttcac accccgggta ggggtggtgg cgccgattgg tgtcacctaa tctactcggg
    16741 gtagtgttct gttcggagca agttataagc tgccccggca ggtgccagaa gagcccggcg
    16801 atataggaac aacaatccag gaaatagcgc aggaatgtac cggaaggaac actgtggccc
    16861 acaagaaaaa agcggtatcc tcacagaacg agcgtaaact cagccgacgt ggattcatga
    16921 taggcgccag cagcacgggg ctactgggcc tgctgagttt acgcctactg tacgttcagg
    16981 ggcttgaccc gcaaaacctg gctgcaacct cccgggattc tcgaacccga acccagaaag
    17041 ttcccgcagt ccgcgggcag attaccgatg tgaacgggca tgtactggcc cgtagtgtgc
    17101 aaaggtacaa tatcatcgcg gaccagacga tcgtggcgga atttaaacgt tacgaccact
    17161 cccaagagcg tgtgacagtc acccccaccg agctggtgta cgaggtcacc gatattttgc
    17221 gcaccgtgga cccgaccatc accgatgact tcgtgaagtc aaaacttgag ggagactccc
    17281 ggtattcggt cattaaaacc aacgtaaccc ccgaaattta caatcgtatc gacgcattag
    17341 gggcgccgtt cctcttcggg gaagtaatca gcgaacgcct gtaccccgac gggccggtgg
    17401 gtggttctgt ggtaggtcgc taccgcatcg ttgatgaagc agttgagggt aaagaaaacg
    17461 aaaccgttga acgcaacctc tcggtaggga ttgagcgcac cttcgagaag gaactcgctg
    17521 gggtgaacgg caaacgcgtg tacgagatcg gggccgacgg tgtgcgtatt cctgtgaccc
    17581 aggagcaggt gagcgaatca gtgaacggta aaaccgtgcg tctgaccctc aaccgggata
    17641 tccagtacta cgcccagcag gttatgaaag cccgtgtaga cgaactcaaa gcagaatggg
    17701 gatgcgccat tgtgatggat gtacgcgacg gctcaatcct ggcacttgct gattcaacaa
    17761 ccatggaccc gggcgccgaa aaagttgaga acgcacaaga tatggtgcca cgtgccattt
    17821 ctcagattat tgaacccgga tcgacggaga aaatcctcac cgcatcagcg ctcattgaga
    17881 aaggcattac cacccccacc gatacatatg atgtgcccgc caccctcacc gttaacgggc
    17941 aaaccttcaa agatgctttt gagcaccccg cgcaacgccg cacgttctcg ggtattatta
    18001 ccgattcgat gaacaccgga actgtgctgg ttggccagaa gatgcccaaa gaagagcgct
    18061 atgagtggct gaaaaaatac ggtatgggcg agttcacagg tattgatatt gccggggagc
    18121 agcagggcct agtctccgat tggaaaacct gggacggacg ccaggaattc acggtgtttt
    18181 ttggtcaggg ccttgcacag accccgcttc agaccgctat ggtttttcag gccgtaggta
    18241 acctgggggt taaagtgaag ccacggattg tggacgcgat tatcgacccc gacggcaccg
    18301 agcataaggt tcccgtagag ggcgcccagc gtgtggtgag tgaaaaaacc gcccgagact
    18361 gcctgaccct catggagaat gtggtgacta aggggcaagc gaaactcgcc caggtcaacg
    18421 ggtaccgtgt cgggggtaaa accggtaccg cagaggcgcc cagcgaaaaa ggcggctatg
    18481 agggatacac cacatctttc attggtgtgg cgcccattga gaacccccgg tttatggtga
    18541 gtatcactct gcagcgcccc aaaggtgagg tgggaactat tggtggtacc gggcaattct
    18601 cccaaatcat ggagcgagtt ctgcacacct acaatattcc gcactccacc accgagccac
    18661 atattatccc catttttgcg gatggtaaga acagcggcta gtctcgtgag ggtgccgagc
    18721 acccgttggc tcattacaat gagaaggtac caatcgcccc agcccagctg tggcacatca
    18781 caagacgata aatagggcgc cccatgcgcg aaggaagaag gacaatgaac ggcgaacagc
    18841 ccggtgagaa actctcagac gaagctatgc ctggcgaaga gctgttcggc aaagatgccc
    18901 agaacttacg gccccgccta accacaggct acccgctaga tacgctcatt cagaagctgc
    18961 aaaaccttga ggcacagccg cgcctagccc tatccggttc ccgaaacgtg accggtatca
    19021 gtatggactc acgctccgta cgcgagggtg atctatatgt agcgctgcca ggtgctaaaa
    19081 cacacggagc tagtttcgct gcagctgctg tagccgcagg cgcagcgggt attcttactg
    19141 acgctcaggg gcagtgcatt attgctgagg cgcaccttga tttagcagat actgcgctta
    19201 ttattggcac agatttacgc cgggtgctgg gttccttggc ggctttcatc tacggttcaa
    19261 acgactaccc gcaactgcag cggttcgcgg tgaccggaac aaacgggaaa actaccacca
    19321 cctatatgct tgaatccgtt ttccgtgccg ctctgggcgt caaaaccggg ttggtcggta
    19381 ccatccaaat ccttattgac ggtgtgtcga ttccctccgc gatgaccacc cccgaatctg
    19441 tgcatgtgca cgccctgctg tctctcatgg gccagcgtgg agtacgttgt gcagctatgg
    19501 aagtctcttc ccacgccatt gattatcgcc gcgttgacgg ggtgcgttat gcaatgagtg
    19561 gtttcacaaa cctcacccaa gaccacctag acctacacgg tgggatggaa gaatactttg
    19621 actcaaaagc acagctgttc acccctgaac gtactgaacg ggccgtgatc accgcagacg
    19681 attcatgggg gcagcggatg cttgtgcacg cacaacagca gctgggtgcg caaaacacaa
    19741 ttcggttgct gaccaatcac ggtgccgggt tagaatcggt accggcagat tttggtgcca
    19801 acgattgggc tgtcactgag gtgacggctc aagggttagg gcataccttc gtacttgcta
    19861 acggggctgg ggagcgtgtt caggctcgta ccggacttcc cgcagatttt aacgtttcca
    19921 atgcggccct agcggcgctt atggcctggc tcagcacaag cgaagaagag agagagccgt
    19981 tggcggctgc gctcgccagt ggggaggcac tcaccccggt agttcctggt cgaatgcagc
    20041 ttattgggca cagcccccac actattgttg attttgcgca taatcctgac gggctaatcc
    20101 gtgcgttaga ggcgatggac cgccccggtg agggccgagt cattatcgtg ttcggtgcta
    20161 ccggtgaacg tgatcaaggc aagcgcccca ttatgggtga gatcgctgcc cgctacgcag
    20221 atattgttat tgtgaccgat gacgatccgc atggggaaga cccggccccc attcgcgagg
    20281 ctgttgctgc cggtgcgcag caagctatcg ccgctggggc gcgggctcat gaagtacata
    20341 atattgcccc gcgtgctagg gctattgcgc aggccatcga tatggccacc cctgacgatg
    20401 ccgtgctcat tgcgggccgc ggccatgaaa cagcccaaga tgtagctggg gtagacgtgc
    20461 agctggatga ccgtattgaa gtggcccgcg ccatggttac tcgcggattt gagattctgc
    20521 cagattatcg gcgtatgctg gaagaaaacg ctgaggataa gaaataatga ttaaactaag
    20581 tgccgccgag attatccagg cgaccggagg tgccgcgctc gggcttcaag accccgagac
    20641 ggtcttctgt accttcgcca ctactgattc acgggaagta gtccccggta ccctttttat
    20701 tgcgaaaccg ggagaaagta ccgacgggca ccgttttgtt gccgcggctt ttaactctgg
    20761 tgcttcctta gctcttgtgg agcggcccgt taccgctgag ccttcagatg agctgtatcc
    20821 tgccgtgcag gtggatgacg cggtactggc gatggggcgc ttggcggcat acgctatcga
    20881 gaagatgcgt agtcttggtc ccgtggaagt cattgggatt accggttccg cagggaaaac
    20941 caccaccaaa gacatgctgg cagctatttt gggtgctgaa ggcgctacgg tggctcccgt
    21001 gggttcctat aacagtgagg ttggggtgcc gctgacggta ttccgtgcgg atgaaaccac
    21061 ccggtacttg gttattgaaa tgggtgccga ccatgtaggc aatattgagt acctggcgaa
    21121 tatcgtacag ccgg
//
