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### Identified secondary metabolite regions using strictness 'relaxed'

NZ_LR134479.1 (Rothia aeria)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1 | lassopeptide,lanthipeptide-class-ii | 246,015 | 287,919 |
Region 2 | terpene-precursor | 867,370 | 888,503 |
Region 3 | NRPS | 1,575,724 | 1,619,980 | High | enterobactin | NRPS:Type I

NZ_LR134479.1 - Region 1 - lanthipeptide-class-ii,lassopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
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Location: 246,015 - 287,919 nt. (total: 41,905 nt) Show pHMM detection rules used
lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
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Gene details
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Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
Lasso peptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
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Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
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Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase reductase
EL250_RS01215: alkyl hydroperoxide reductase/ Thiol specific

smcogs
  SMCOG1196: alkyl hydroperoxide reductase/ Thiol specific

EL250_RS01295: oxidoreductase

smcogs
  SMCOG1083: oxidoreductase

Transferases: acetyltransferase
EL250_RS01220: GCN5-related N-acetyltransferase

smcogs
  SMCOG1111: GCN5-related N-acetyltransferase

Hydrolases: hydrolase
EL250_RS01250: asparagine synthase (glutamine-hydrolyzing)

smcogs
  SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Lyases: cyclase
EL250_RS01325: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

EL250_RS01335: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Ligases: ligase
EL250_RS01240: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lassopeptide | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001555.4 |  |  | 0.32 | ribosomal | colicin V | Escherichia coli chi7122
BGC0002698.2 |  |  | 0.31 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000517.4 |  |  | 0.30 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000575.5 |  |  | 0.30 | ribosomal | lariatin | Rhodococcus jostii
BGC0000504.5 |  |  | 0.29 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001889.2 |  |  | 0.29 | ribosomal | fusilassin | Thermobifida fusca YX
BGC0001210.5 |  |  | 0.29 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000589.5 |  |  | 0.29 | ribosomal | microcin M | Escherichia coli Nissle 1917
BGC0000588.5 |  |  | 0.29 | ribosomal | microcin L | Escherichia coli
BGC0000500.5 |  |  | 0.28 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001176.4 |  | 0.61 | ribosomal | streptomonomicin | Streptomonospora alba
BGC0001229.4 |  | 0.59 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0002110.3 |  | 0.56 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0002698.2 |  | 0.54 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0002150.2 |  | 0.54 | ribosomal | triculamin | Streptomyces triculaminicus
BGC0002151.2 |  | 0.54 | ribosomal | alboverticillin | Streptomyces griseocarneus
BGC0001555.4 |  | 0.52 | ribosomal | colicin V | Escherichia coli chi7122
BGC0001634.3 |  | 0.51 | ribosomal | keywimysin | Streptomyces sp. NRRL F-5702
BGC0000575.5 |  | 0.51 | ribosomal | lariatin | Rhodococcus jostii
BGC0001549.3 |  | 0.51 | ribosomal | citrulassin B | Streptomyces aurantiacus JA 4570

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for EL250_RS01325

EL250_RS01320
Leader:
MAKDTMFMEELTDQELEQVNGG
Core:
C Y S S C G Y Y G G S Y G G S Y G G S Y G G S S S S Y Y G G S Y S G G G Y Y Y A A V G Y G Y S C
Core with dehydrations:
Cys Y Dha Dha Cys G Y Y G G Dha Y G G Dha Y G G Dha Y G G Dha Dha Dha Dha Y Y G G Dha Y Dha G G G Y Y Y A A V G Y G Y Dha Cys

#### antiSMASH-DB 4.0 matches for EL250_RS01320

100.0%
NZ_LR134479.1 and 1 other:
NZ_LR134479.1 Lanthipeptides: EL250_RS01320_lanthipeptide
Lanthipeptides: EL250_RS01320_lanthipeptide
1
C Y S S C G Y Y G G S Y G G S Y G G S Y G G S S S S Y Y G G S Y S G G G Y Y Y A A V G Y G Y S C
48
C Y S S C G Y Y G G S Y G G S Y G G S Y G G S S S S Y Y G G S Y S G G G Y Y Y A A V G Y G Y S C
1
C Y S S C G Y Y G G S Y G G S Y G G S Y G G S S S S Y Y G G S Y S G G G Y Y Y A A V G Y G Y S C
48
97.9%
NZ_CP079819.1 and 1 other:
NZ_CP079819.1 Lanthipeptides: LPB401_RS00090_lanthipeptide
Lanthipeptides: LPB401_RS00090_lanthipeptide
1
C Y S S C G Y Y G G S Y G G S Y G G S Y G G S S S S Y Y G G S Y S G G G Y Y Y A A V G Y G Y S C
48
C Y S S C G Y Y G G S Y G G S Y G G S Y G S S S S Y Y G G S Y S G G G Y Y Y A A V G Y G Y S C
1
C Y S S C G Y Y G G S Y G G S Y G G S Y C G S S S S Y Y G G S Y S G G G Y Y Y A A V G Y G Y S C
48
97.9%
NZ_KI518028.1 and 1 other:
NZ_KI518028.1 Lanthipeptides: HMPREF0742_RS01810_lanthipeptide
Lanthipeptides: HMPREF0742_RS01810_lanthipeptide
1
C Y S S C G Y Y G G S Y G G S Y G G S Y G G S S S S Y Y G G S Y S G G G Y Y Y A A V G Y G Y S C
48
C Y S S C G Y Y G G S Y G G S Y G G S Y G G S+S S Y Y G G S Y S G G G Y Y Y A A V G Y G Y S C
1
C Y S S C G Y Y G G S Y G G S Y G G S Y G G S N S S Y Y G G S Y S G G G Y Y Y A A V G Y G Y S C
48

#### MIBiG 4.0 matches for EL250_RS01320

8.3%
BGC0000581.6 (AAD28494.1):
Lasso peptide: microcin J25
22
G S S S S Y Y G
29
G+ S+Y G
14
G T P I S F Y G
21
EL250_RS01330
Leader:
MPKDITLLEEISDQELGQVNGG
Core:
G S H G G G Y Y S S V G G G S Y G G G Y C G G G C G G Y G Y G F G F W G G S F S
Core with dehydrations:
G Dha H G G G Y Y Dha Dha V G G G Dha Y G G G Y Cys G G G Cys G G Y G Y G F G F W G G Dha F Dha

#### antiSMASH-DB 4.0 matches for EL250_RS01330

100.0%
NZ_CP068102.1 and 7 others:
NZ_CP068102.1 Lanthipeptides: I6I94_RS04840_lanthipeptide NZ_CP079819.1 Lanthipeptides: LPB401_RS00100_lanthipeptide NZ_CP079819.1 Lanthipeptides: LPB401_RS00100_lanthipeptide NZ_KI518028.1 Lanthipeptides: HMPREF0742_RS01820_lanthipeptide NZ_KI518028.1 Lanthipeptides: HMPREF0742_RS01820_lanthipeptide NZ_LR134479.1 Lanthipeptides: EL250_RS01330_lanthipeptide NZ_LR134479.1 Lanthipeptides: EL250_RS01330_lanthipeptide
Lanthipeptides: I6I94_RS04840_lanthipeptide
1
G S H G G G Y Y S S V G G G S Y G G G Y C G G G C G G Y G Y G F G F W G G S F S
40
G S H G G G Y Y S S V G G G S Y G G G Y C G G G C G G Y G Y G F G F W G G S F S
1
G S H G G G Y Y S S V G G G S Y G G G Y C G G G C G G Y G Y G F G F W G G S F S
40
18.2%
NC_014643.1 and 16 others:
NC_014643.1 Lanthipeptides: HMPREF0733_RS05060_lanthipeptide NZ_CP054018.1 Lanthipeptides: FOC60_RS00340_lanthipeptide NZ_CP079201.1 Lanthipeptides: LPB409_RS01335_lanthipeptide NZ_JVLW01000024.1 Lanthipeptides: ADD47_RS04725_lanthipeptide NZ_JVXR01000038.1 Lanthipeptides: ADK06_RS05015_lanthipeptide NZ_KV793075.1 Lanthipeptides: HMPREF3164_RS06945_lanthipeptide NZ_KV795763.1 Lanthipeptides: HMPREF2554_RS09025_lanthipeptide NZ_KV795763.1 Lanthipeptides: HMPREF2554_RS09025_lanthipeptide NZ_KV797630.1 Lanthipeptides: HMPREF2609_RS06005_lanthipeptide NZ_KV797887.1 Lanthipeptides: HMPREF2625_RS00515_lanthipeptide NZ_KV802313.1 Lanthipeptides: HMPREF2756_RS06530_lanthipeptide NZ_KV804818.1 Lanthipeptides: HMPREF2804_RS09475_lanthipeptide NZ_KV804818.1 Lanthipeptides: HMPREF2804_RS09475_lanthipeptide NZ_KV815277.1 Lanthipeptides: HMPREF2958_RS01940_lanthipeptide NZ_KV817389.1 Lanthipeptides: HMPREF2981_RS04625_lanthipeptide NZ_KV820076.1 Lanthipeptides: HMPREF3016_RS03055_lanthipeptide
Lanthipeptides: HMPREF0733_RS05060_lanthipeptide
30
Y G F G F W G G S
38
+G F G F W G G S
34
F G F G F W G G S
42

#### MIBiG 4.0 matches for EL250_RS01330

15.0%
BGC0002322.3 (CEJ66604.1):
Lasso peptide: citrocin
20
Y C G G G C G G Y G
29
+ G G G G Y G
10
F I G G G V G R Y G
19
allorf_0261182_0261298
Leader:
MNEIQLIGA
Core:
P Q P P P T R G T R G A L R R A P A Q E C I K I R Y V R G
Core with dehydrations:
P Q P P P Dhb R G Dhb R G A L R R A P A Q E Cys I K I R Y V R G

#### antiSMASH-DB 4.0 matches for allorf_0261182_0261298

100.0%
NZ_LR134479.1:
Lanthipeptides: allorf_0261182_0261298_lanthipeptide
1
P Q P P P T R G T R G A L R R A P A Q E C I K I R Y V R G
29
P Q P P P T R G T R G A L R R A P A Q E C I K I R Y V R G
1
P Q P P P T R G T R G A L R R A P A Q E C I K I R Y V R G
29
96.6%
NZ_KI518028.1:
Lanthipeptides: allorf_287397_287513_lanthipeptide
1
P Q P P P T R G T R G A L R R A P A Q E C I K I R Y V R G
29
P Q P P P T R G T R G A L R R A P A Q+C I K I R Y V R G
1
P Q P P P T R G T R G A L R R A P A Q K C I K I R Y V R G
29
93.1%
NZ_CP068102.1:
Lanthipeptides: allorf_1185663_1185779_lanthipeptide
1
P Q P P P T R G T R G A L R R A P A Q E C I K I R Y V R G
29
P Q P P P T R G T R G A L R R A P A++C I K I R Y V R G
1
P Q P P P T R G T R G A L R R A P A R K C I K I R Y V R G
29
with 4 more sequence matches
27.0%
NZ_CP013219.1:
Lanthipeptides: allorf_0179059_0179217_lanthipeptide
1
P Q P P P T R G T R G A L R R A P A Q
19
P P P G R G A R R P +
16
P V P P A D G G P R G A G R R V P C R
34
24.1%
NZ_CP026498.1:
Lanthipeptides: allorf_00224338_00224481_lanthipeptide
5
P T R G T R G A L R R A P A Q
19
P G+R G +R R P +
1
P R N G S R G G V R R R P G E
15
22.2%
NZ_FNPT01000012.1:
Lanthipeptides: allorf_041529_041675_lanthipeptide
1
P Q P P P T R G T R G A L R R A P
17
P P R R A L R P
13
P H P A F A R A D R A A L R T G P
29
15.2%
NZ_LR881952.1 and 4 others:
NZ_LR881952.1 Lanthipeptides: allorf_5341425_5341625_lanthipeptide NZ_LR881952.1 Lanthipeptides: allorf_5341425_5341625_lanthipeptide NZ_LR881952.1 Lanthipeptides: allorf_5341425_5341625_lanthipeptide NZ_LZQS01000002.1 Lanthipeptides: allorf_595585_595785_lanthipeptide
Lanthipeptides: allorf_5341425_5341625_lanthipeptide
16
A P A Q E C I K I R Y V R G
29
A P A E +++R Y G
11
A P A W E T L R L R Y G A G
24
allorf_0265595_0265780
Leader:
MTKYCMSHAKYYGA
Core:
E S Q K L M F V I Y C S P P S A R G Y T Q N A R I M S P G V K L W L A G R Q P S P V A G C P R
Core with dehydrations:
E Dha Q K L M F V I Y Cys Dha P P Dha A R G Y Dhb Q N A R I M Dha P G V K L W L A G R Q P Dha P V A G Cys P R

#### antiSMASH-DB 4.0 matches for allorf_0265595_0265780

100.0%
NZ_CP079819.1 and 5 others:
NZ_CP079819.1 Lanthipeptides: allorf_0008942_0009127_lanthipeptide NZ_KI518028.1 Lanthipeptides: allorf_291815_292000_lanthipeptide NZ_KI518028.1 Lanthipeptides: allorf_291815_292000_lanthipeptide NZ_LR134479.1 Lanthipeptides: allorf_0265595_0265780_lanthipeptide NZ_LR134479.1 Lanthipeptides: allorf_0265595_0265780_lanthipeptide
Lanthipeptides: allorf_0008942_0009127_lanthipeptide
1
E S Q K L M F V I Y C S P P S A R G Y T Q N A R I M S P G V K L W L A G R Q P S P V A G C P R
47
E S Q K L M F V I Y C S P P S A R G Y T Q N A R I M S P G V K L W L A G R Q P S P V A G C P R
1
E S Q K L M F V I Y C S P P S A R G Y T Q N A R I M S P G V K L W L A G R Q P S P V A G C P R
47
34.0%
NZ_CP068102.1 and 1 other:
NZ_CP068102.1 Lanthipeptides: allorf_1181240_1181359_lanthipeptide
Lanthipeptides: allorf_1181240_1181359_lanthipeptide
1
E S Q K L M F V I Y C S P P S A R G Y T
20
E S Q K L M F V I Y C S P R G T
1
E S Q K L M F V I Y C S-P H L R G D T
19
14.9%
NZ_CP054018.1:
Lanthipeptides: allorf_0093622_0093795_lanthipeptide
2
S Q K L M F V I Y C S P P S A R G Y T Q N A R
24
+ L+F + C S R G+ R
1
N N A L I F F V C C R S S S I R G H V S R I R
23
allorf_0265627_0265695
Leader:
MYPLADGGEQYM
Core:
T N I N F C D S A P
Core with dehydrations:
Dhb N I N F Cys D Dha A P

#### antiSMASH-DB 4.0 matches for allorf_0265627_0265695

100.0%
NZ_CP079819.1 and 5 others:
NZ_CP079819.1 Lanthipeptides: allorf_0008974_0009042_lanthipeptide NZ_KI518028.1 Lanthipeptides: allorf_291847_291915_lanthipeptide NZ_KI518028.1 Lanthipeptides: allorf_291847_291915_lanthipeptide NZ_LR134479.1 Lanthipeptides: allorf_0265627_0265695_lanthipeptide NZ_LR134479.1 Lanthipeptides: allorf_0265627_0265695_lanthipeptide
Lanthipeptides: allorf_0008974_0009042_lanthipeptide
1
T N I N F C D S A P
10
T N I N F C D S A P
1
T N I N F C D S A P
10
allorf_0265696_0265836
Leader:
MCRWRIRAVLAS
Core:
C S L K P D H H L G H P A T G E G C R P A S Q S F T P G L I I L A F
Core with dehydrations:
Cys Dha L K P D H H L G H P A Dhb G E G Cys R P A Dha Q Dha F Dhb P G L I I L A F

#### antiSMASH-DB 4.0 matches for allorf_0265696_0265836

100.0%
NZ_CP068102.1 and 7 others:
NZ_CP068102.1 Lanthipeptides: allorf_1181119_1181259_lanthipeptide NZ_CP079819.1 Lanthipeptides: allorf_0009043_0009246_lanthipeptide NZ_CP079819.1 Lanthipeptides: allorf_0009043_0009246_lanthipeptide NZ_KI518028.1 Lanthipeptides: allorf_291916_292056_lanthipeptide NZ_KI518028.1 Lanthipeptides: allorf_291916_292056_lanthipeptide NZ_LR134479.1 Lanthipeptides: allorf_0265696_0265836_lanthipeptide NZ_LR134479.1 Lanthipeptides: allorf_0265696_0265836_lanthipeptide
Lanthipeptides: allorf_1181119_1181259_lanthipeptide
1
C S L K P D H H L G H P A T G E G C R P A S Q S F T P G L I I L A F
34
C S L K P D H H L G H P A T G E G C R P A S Q S F T P G L I I L A F
1
C S L K P D H H L G H P A T G E G C R P A S Q S F T P G L I I L A F
34
23.5%
NZ_CP069338.1 and 1 other:
NZ_CP069338.1 Lanthipeptides: allorf_09109175_09109414_lanthipeptide
Lanthipeptides: allorf_09109175_09109414_lanthipeptide
8
H L G H P A T G E G C R P A S Q S F T
26
G P E G P +S F T
7
E F G A P P L K E G N H P C L E S F T
25
23.5%
NZ_SNZH01000011.1:
Lanthipeptides: allorf_218796_219029_lanthipeptide
14
T G E G C R P A S Q S F T
26
T G G C R A S T
1
T G S G C R K A G P S H T
13
with 1 more sequence matches
14.6%
NZ_LIPB01000002.1:
Lanthipeptides: allorf_1135461_1135619_lanthipeptide
11
H P A T G E G C R
19
H P G G C R
10
H P W G G S G C R
18

#### MIBiG 4.0 matches for allorf_0265696_0265836

11.8%
BGC0000580.3 (EGD17355.1):
Lasso peptide: xanthomonin II or xanthomonin I
10
G H P A T G E
16
G P G E
1
G G P L A G E
7
8.8%
BGC0000566.5 (SPy_0738):
LAP: streptolysin S
25
F T P G
28
+T P G
26
Y T P G
29
allorf_0265791_0265895
Leader:
MFLHPARRLLIGG
Core:
G L L G V P S C A G G A F A P Y L L R V P
Core with dehydrations:
G L L G V P Dha Cys A G G A F A P Y L L R V P

#### antiSMASH-DB 4.0 matches for allorf_0265791_0265895

100.0%
NZ_CP068102.1 and 5 others:
NZ_CP068102.1 Lanthipeptides: allorf_1181060_1181164_lanthipeptide NZ_CP079819.1 Lanthipeptides: allorf_0009138_0009242_lanthipeptide NZ_CP079819.1 Lanthipeptides: allorf_0009138_0009242_lanthipeptide NZ_LR134479.1 Lanthipeptides: allorf_0265791_0265895_lanthipeptide NZ_LR134479.1 Lanthipeptides: allorf_0265791_0265895_lanthipeptide
Lanthipeptides: allorf_1181060_1181164_lanthipeptide
1
G L L G V P S C A G G A F A P Y L L R V P
21
G L L G V P S C A G G A F A P Y L L R V P
1
G L L G V P S C A G G A F A P Y L L R V P
21
26.9%
NC_014483.2 and 23 others:
NC_014622.2 Lanthipeptides: PPSC2_RS36205_lanthipeptide NC_017542.1 Lanthipeptides: PPM_RS07465_lanthipeptide NZ_CP006872.1 Lanthipeptides: PPSQR21_RS07740_lanthipeptide NZ_CP023711.1 Lanthipeptides: CPY53_RS22235_lanthipeptide NZ_CP025957.1 Lanthipeptides: C1A50_RS07530_lanthipeptide NZ_CP029370.1 Lanthipeptides: DI243_RS07495_lanthipeptide NZ_CP040829.1 Lanthipeptides: FGY93_RS00500_lanthipeptide NZ_CP049598.1 Lanthipeptides: G7L40_RS00115_lanthipeptide NZ_CP061172.1 Lanthipeptides: IAQ67_RS07480_lanthipeptide NZ_CP073682.1 Lanthipeptides: KAI36_RS07745_lanthipeptide NZ_CP084033.1 Lanthipeptides: LAZ93_RS07550_lanthipeptide NZ_CP085682.1 Lanthipeptides: LJR53_RS07370_lanthipeptide NZ_CP086373.1 Lanthipeptides: LMH85_RS07780_lanthipeptide NZ_CP092779.1 Lanthipeptides: MJ749_RS07440_lanthipeptide NZ_CP097766.1 Lanthipeptides: MF620_RS07485_lanthipeptide NZ_CP102865.1 Lanthipeptides: NWS42_RS21195_lanthipeptide NZ_CP109848.1 Lanthipeptides: OF859_RS22650_lanthipeptide NZ_CP113973.1 Lanthipeptides: OYT09_RS07785_lanthipeptide NZ_JAAMNR010000001.1 Lanthipeptides: G9G54_RS03500_lanthipeptide NZ_JWJJ01000002.1 Lanthipeptides: U707_RS10390_lanthipeptide NZ_PNXQ01000013.1 Lanthipeptides: C1I60_RS14430_lanthipeptide NZ_POVS01000009.1 Lanthipeptides: C1T21_RS10630_lanthipeptide NZ_POVT01000009.1 Lanthipeptides: C1T20_RS05900_lanthipeptide
Lanthipeptides: PPE_RS07020_lanthipeptide
1
G L L G V P S C A G G A F
13
G L+ P S C A G
2
G L I C T P S C A T G T L
14
23.1%
NC_023037.2 and 6 others:
NZ_CP017967.2 Lanthipeptides: PPYC1_RS07755_lanthipeptide NZ_CP017968.3 Lanthipeptides: PPYC2_RS08330_lanthipeptide NZ_CP073683.1 Lanthipeptides: KAI37_RS07495_lanthipeptide NZ_FOYG01000001.1 Lanthipeptides: BM358_RS03525_lanthipeptide NZ_JAKVDC010000001.1 Lanthipeptides: MKN04_RS02755_lanthipeptide NZ_PTJM01000020.1 Lanthipeptides: C5G87_RS02825_lanthipeptide
Lanthipeptides: X809_RS07820_lanthipeptide
1
G L L G V P S C A G G A F
13
G++ P S C A G
2
G I I C T P S C A T G T L
14
with 2 more sequence matches
15.7%
NZ_WWJS01000019.1:
Lanthipeptides: GT018_RS20925_lanthipeptide
1
G L L G V P S C A G G A F A P Y
16
G V P +G G A P Y
5
G C Q S V P D Q S G G V V A P Y
20
14.3%
NC_017765.1 and 1 other:
NZ_KQ948355.1 Lanthipeptides: AQJ11_RS50945_lanthipeptide
Lanthipeptides: SHJG_RS52475_lanthipeptide
5
V P S C A G G A F A P Y
16
V P+C A G G P+
33
V P A C A G G I A R P F
44

#### MIBiG 4.0 matches for allorf_0265791_0265895

19.0%
BGC0000503.5 (cinA):
Lanthipeptide: cinnamycin
7
S C A G G A F A
14
S C+ G F
4
S C S F G P F T
11
allorf_0269996_0270211
Leader:
MEIMMRTYCILPRWFDTVEGLARVAISLLQGRELIVGVLLRMQRMDSIESFRKLILGS
Core:
Y C V I G T V L H S H I S
Core with dehydrations:
Y Cys V I G Dhb V L H Dha H I Dha

#### antiSMASH-DB 4.0 matches for allorf_0269996_0270211

100.0%
NZ_CP068102.1 and 7 others:
NZ_CP068102.1 Lanthipeptides: allorf_1176779_1176994_lanthipeptide NZ_CP079819.1 Lanthipeptides: allorf_0013342_0013557_lanthipeptide NZ_CP079819.1 Lanthipeptides: allorf_0013342_0013557_lanthipeptide NZ_KI518028.1 Lanthipeptides: allorf_295232_295447_lanthipeptide NZ_KI518028.1 Lanthipeptides: allorf_295232_295447_lanthipeptide NZ_LR134479.1 Lanthipeptides: allorf_0269996_0270211_lanthipeptide NZ_LR134479.1 Lanthipeptides: allorf_0269996_0270211_lanthipeptide
Lanthipeptides: allorf_1176779_1176994_lanthipeptide
1
Y C V I G T V L H S H I S
13
Y C V I G T V L H S H I S
1
Y C V I G T V L H S H I S
13
24.0%
NZ_JACHNX010000043.1:
Lanthipeptides: allorf_0139_0258_lanthipeptide
2
C V I G T V L H S H
11
C V I G H S
16
C V I G E A D H S E
25
10.3%
NZ_CP045142.1:
Lanthipeptides: GBQ70_RS07075_lanthipeptide
1
Y C V I G T V L H S H I S
13
Y C T L H H S
40
Y C D T P T R L H R H E S
52
allorf_0270096_0270281
Leader:
MLCALIALYYG
Core:
H H I T K W C D I K W K L R I C E S V K L F L S H N R S P I S A F G S S Q C Y P F F A S S I E H P Q
Core with dehydrations:
H H I Dhb K W Cys D I K W K L R I Cys E Dha V K L F L Dha H N R Dha P I Dha A F G Dha Dha Q Cys Y P F F A Dha Dha I E H P Q

#### antiSMASH-DB 4.0 matches for allorf_0270096_0270281

100.0%
NZ_KI518028.1 and 3 others:
NZ_KI518028.1 Lanthipeptides: allorf_295332_295517_lanthipeptide NZ_LR134479.1 Lanthipeptides: allorf_0270096_0270281_lanthipeptide NZ_LR134479.1 Lanthipeptides: allorf_0270096_0270281_lanthipeptide
Lanthipeptides: allorf_295332_295517_lanthipeptide
1
H H I T K W C D I K W K L R I C E S V K L F L S H N R S P I S A F G S S Q C Y P F F A S S I E H P Q
50
H H I T K W C D I K W K L R I C E S V K L F L S H N R S P I S A F G S S Q C Y P F F A S S I E H P Q
1
H H I T K W C D I K W K L R I C E S V K L F L S H N R S P I S A F G S S Q C Y P F F A S S I E H P Q
50
98.0%
NZ_CP068102.1 and 1 other:
NZ_CP068102.1 Lanthipeptides: allorf_1176709_1176894_lanthipeptide
Lanthipeptides: allorf_1176709_1176894_lanthipeptide
1
H H I T K W C D I K W K L R I C E S V K L F L S H N R S P I S A F G S S Q C Y P F F A S S I E H P Q
50
H H I T K W C D I K W K L R I C E S V K L F L S H N R S P I S A F G S S+C Y P F F A S S I E H P Q
1
H H I T K W C D I K W K L R I C E S V K L F L S H N R S P I S A F G S S R C Y P F F A S S I E H P Q
50
12.0%
NZ_JAMDLZ010000027.1:
Lanthipeptides: M5W82_RS15515_lanthipeptide
5
K W C D I K W K L R I C
16
K W C + W+ I C
13
K W C T L T W E C S I C
24
with 3 more sequence matches
12.0%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS00795_lanthipeptide
Lanthipeptides: B2C77_RS00795_lanthipeptide
5
K W C D I K W K L R I C E S
18
K W C + W+ I C +
14
K W C T V T W E C S I C P T
27
10.0%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04105_lanthipeptide
Lanthipeptides: MFF31_RS04105_lanthipeptide
5
K W C D I K W K L R I C E S V K L F
22
K+C + W+ +C ++ F
13
K Y C T L T W E C S V C P T L T C F
30
10.0%
NZ_CP013979.1:
Lanthipeptides: ATC03_RS01475_lanthipeptide
26
N R S P I S A F G S S Q C Y P F F A S
44
+P+ F G C P+++
1
G T N P L G T F G C C W C V P W W S G
19
allorf_0270410_0270481
Leader:
MVENRDLASS
Core:
S P K H S T I K N C S R K
Core with dehydrations:
Dha P K H Dha Dhb I K N Cys Dha R K

#### antiSMASH-DB 4.0 matches for allorf_0270410_0270481

100.0%
NZ_LR134479.1 and 1 other:
NZ_LR134479.1 Lanthipeptides: allorf_0270410_0270481_lanthipeptide
Lanthipeptides: allorf_0270410_0270481_lanthipeptide
1
S P K H S T I K N C S R K
13
S P K H S T I K N C S R K
1
S P K H S T I K N C S R K
13
92.3%
NZ_CP079819.1 and 3 others:
NZ_CP079819.1 Lanthipeptides: allorf_0013756_0013827_lanthipeptide NZ_KI518028.1 Lanthipeptides: allorf_295646_295717_lanthipeptide NZ_KI518028.1 Lanthipeptides: allorf_295646_295717_lanthipeptide
Lanthipeptides: allorf_0013756_0013827_lanthipeptide
1
S P K H S T I K N C S R K
13
S P K H S I K N C S R K
1
S P K H S A I K N C S R K
13
84.6%
NZ_CP068102.1 and 1 other:
NZ_CP068102.1 Lanthipeptides: allorf_1176509_1176580_lanthipeptide
Lanthipeptides: allorf_1176509_1176580_lanthipeptide
1
S P K H S T I K N C S R K
13
S P K+S I K N C S R K
1
S P K Y S A I K N C S R K
13

#### Lanthipeptide(s) for EL250_RS01335

EL250_RS01320
Leader:
MAKDTMFMEELTDQELEQVNGG
Core:
C Y S S C G Y Y G G S Y G G S Y G G S Y G G S S S S Y Y G G S Y S G G G Y Y Y A A V G Y G Y S C
Core with dehydrations:
Cys Y Dha Dha Cys G Y Y G G Dha Y G G Dha Y G G Dha Y G G Dha Dha Dha Dha Y Y G G Dha Y Dha G G G Y Y Y A A V G Y G Y Dha Cys

#### antiSMASH-DB 4.0 matches for EL250_RS01320

100.0%
NZ_LR134479.1 and 1 other:
NZ_LR134479.1 Lanthipeptides: EL250_RS01320_lanthipeptide
Lanthipeptides: EL250_RS01320_lanthipeptide
1
C Y S S C G Y Y G G S Y G G S Y G G S Y G G S S S S Y Y G G S Y S G G G Y Y Y A A V G Y G Y S C
48
C Y S S C G Y Y G G S Y G G S Y G G S Y G G S S S S Y Y G G S Y S G G G Y Y Y A A V G Y G Y S C
1
C Y S S C G Y Y G G S Y G G S Y G G S Y G G S S S S Y Y G G S Y S G G G Y Y Y A A V G Y G Y S C
48
97.9%
NZ_CP079819.1 and 1 other:
NZ_CP079819.1 Lanthipeptides: LPB401_RS00090_lanthipeptide
Lanthipeptides: LPB401_RS00090_lanthipeptide
1
C Y S S C G Y Y G G S Y G G S Y G G S Y G G S S S S Y Y G G S Y S G G G Y Y Y A A V G Y G Y S C
48
C Y S S C G Y Y G G S Y G G S Y G G S Y G S S S S Y Y G G S Y S G G G Y Y Y A A V G Y G Y S C
1
C Y S S C G Y Y G G S Y G G S Y G G S Y C G S S S S Y Y G G S Y S G G G Y Y Y A A V G Y G Y S C
48
97.9%
NZ_KI518028.1 and 1 other:
NZ_KI518028.1 Lanthipeptides: HMPREF0742_RS01810_lanthipeptide
Lanthipeptides: HMPREF0742_RS01810_lanthipeptide
1
C Y S S C G Y Y G G S Y G G S Y G G S Y G G S S S S Y Y G G S Y S G G G Y Y Y A A V G Y G Y S C
48
C Y S S C G Y Y G G S Y G G S Y G G S Y G G S+S S Y Y G G S Y S G G G Y Y Y A A V G Y G Y S C
1
C Y S S C G Y Y G G S Y G G S Y G G S Y G G S N S S Y Y G G S Y S G G G Y Y Y A A V G Y G Y S C
48

#### MIBiG 4.0 matches for EL250_RS01320

8.3%
BGC0000581.6 (AAD28494.1):
Lasso peptide: microcin J25
22
G S S S S Y Y G
29
G+ S+Y G
14
G T P I S F Y G
21
EL250_RS01330
Leader:
MPKDITLLEEISDQELGQVNGG
Core:
G S H G G G Y Y S S V G G G S Y G G G Y C G G G C G G Y G Y G F G F W G G S F S
Core with dehydrations:
G Dha H G G G Y Y Dha Dha V G G G Dha Y G G G Y Cys G G G Cys G G Y G Y G F G F W G G Dha F Dha

#### antiSMASH-DB 4.0 matches for EL250_RS01330

100.0%
NZ_CP068102.1 and 7 others:
NZ_CP068102.1 Lanthipeptides: I6I94_RS04840_lanthipeptide NZ_CP079819.1 Lanthipeptides: LPB401_RS00100_lanthipeptide NZ_CP079819.1 Lanthipeptides: LPB401_RS00100_lanthipeptide NZ_KI518028.1 Lanthipeptides: HMPREF0742_RS01820_lanthipeptide NZ_KI518028.1 Lanthipeptides: HMPREF0742_RS01820_lanthipeptide NZ_LR134479.1 Lanthipeptides: EL250_RS01330_lanthipeptide NZ_LR134479.1 Lanthipeptides: EL250_RS01330_lanthipeptide
Lanthipeptides: I6I94_RS04840_lanthipeptide
1
G S H G G G Y Y S S V G G G S Y G G G Y C G G G C G G Y G Y G F G F W G G S F S
40
G S H G G G Y Y S S V G G G S Y G G G Y C G G G C G G Y G Y G F G F W G G S F S
1
G S H G G G Y Y S S V G G G S Y G G G Y C G G G C G G Y G Y G F G F W G G S F S
40
18.2%
NC_014643.1 and 16 others:
NC_014643.1 Lanthipeptides: HMPREF0733_RS05060_lanthipeptide NZ_CP054018.1 Lanthipeptides: FOC60_RS00340_lanthipeptide NZ_CP079201.1 Lanthipeptides: LPB409_RS01335_lanthipeptide NZ_JVLW01000024.1 Lanthipeptides: ADD47_RS04725_lanthipeptide NZ_JVXR01000038.1 Lanthipeptides: ADK06_RS05015_lanthipeptide NZ_KV793075.1 Lanthipeptides: HMPREF3164_RS06945_lanthipeptide NZ_KV795763.1 Lanthipeptides: HMPREF2554_RS09025_lanthipeptide NZ_KV795763.1 Lanthipeptides: HMPREF2554_RS09025_lanthipeptide NZ_KV797630.1 Lanthipeptides: HMPREF2609_RS06005_lanthipeptide NZ_KV797887.1 Lanthipeptides: HMPREF2625_RS00515_lanthipeptide NZ_KV802313.1 Lanthipeptides: HMPREF2756_RS06530_lanthipeptide NZ_KV804818.1 Lanthipeptides: HMPREF2804_RS09475_lanthipeptide NZ_KV804818.1 Lanthipeptides: HMPREF2804_RS09475_lanthipeptide NZ_KV815277.1 Lanthipeptides: HMPREF2958_RS01940_lanthipeptide NZ_KV817389.1 Lanthipeptides: HMPREF2981_RS04625_lanthipeptide NZ_KV820076.1 Lanthipeptides: HMPREF3016_RS03055_lanthipeptide
Lanthipeptides: HMPREF0733_RS05060_lanthipeptide
30
Y G F G F W G G S
38
+G F G F W G G S
34
F G F G F W G G S
42

#### MIBiG 4.0 matches for EL250_RS01330

15.0%
BGC0002322.3 (CEJ66604.1):
Lasso peptide: citrocin
20
Y C G G G C G G Y G
29
+ G G G G Y G
10
F I G G G V G R Y G
19
allorf_0265595_0265780
Leader:
MTKYCMSHAKYYGA
Core:
E S Q K L M F V I Y C S P P S A R G Y T Q N A R I M S P G V K L W L A G R Q P S P V A G C P R
Core with dehydrations:
E Dha Q K L M F V I Y Cys Dha P P Dha A R G Y Dhb Q N A R I M Dha P G V K L W L A G R Q P Dha P V A G Cys P R

#### antiSMASH-DB 4.0 matches for allorf_0265595_0265780

100.0%
NZ_CP079819.1 and 5 others:
NZ_CP079819.1 Lanthipeptides: allorf_0008942_0009127_lanthipeptide NZ_KI518028.1 Lanthipeptides: allorf_291815_292000_lanthipeptide NZ_KI518028.1 Lanthipeptides: allorf_291815_292000_lanthipeptide NZ_LR134479.1 Lanthipeptides: allorf_0265595_0265780_lanthipeptide NZ_LR134479.1 Lanthipeptides: allorf_0265595_0265780_lanthipeptide
Lanthipeptides: allorf_0008942_0009127_lanthipeptide
1
E S Q K L M F V I Y C S P P S A R G Y T Q N A R I M S P G V K L W L A G R Q P S P V A G C P R
47
E S Q K L M F V I Y C S P P S A R G Y T Q N A R I M S P G V K L W L A G R Q P S P V A G C P R
1
E S Q K L M F V I Y C S P P S A R G Y T Q N A R I M S P G V K L W L A G R Q P S P V A G C P R
47
34.0%
NZ_CP068102.1 and 1 other:
NZ_CP068102.1 Lanthipeptides: allorf_1181240_1181359_lanthipeptide
Lanthipeptides: allorf_1181240_1181359_lanthipeptide
1
E S Q K L M F V I Y C S P P S A R G Y T
20
E S Q K L M F V I Y C S P R G T
1
E S Q K L M F V I Y C S-P H L R G D T
19
14.9%
NZ_CP054018.1:
Lanthipeptides: allorf_0093622_0093795_lanthipeptide
2
S Q K L M F V I Y C S P P S A R G Y T Q N A R
24
+ L+F + C S R G+ R
1
N N A L I F F V C C R S S S I R G H V S R I R
23
allorf_0265627_0265695
Leader:
MYPLADGGEQYM
Core:
T N I N F C D S A P
Core with dehydrations:
Dhb N I N F Cys D Dha A P

#### antiSMASH-DB 4.0 matches for allorf_0265627_0265695

100.0%
NZ_CP079819.1 and 5 others:
NZ_CP079819.1 Lanthipeptides: allorf_0008974_0009042_lanthipeptide NZ_KI518028.1 Lanthipeptides: allorf_291847_291915_lanthipeptide NZ_KI518028.1 Lanthipeptides: allorf_291847_291915_lanthipeptide NZ_LR134479.1 Lanthipeptides: allorf_0265627_0265695_lanthipeptide NZ_LR134479.1 Lanthipeptides: allorf_0265627_0265695_lanthipeptide
Lanthipeptides: allorf_0008974_0009042_lanthipeptide
1
T N I N F C D S A P
10
T N I N F C D S A P
1
T N I N F C D S A P
10
allorf_0265696_0265836
Leader:
MCRWRIRAVLAS
Core:
C S L K P D H H L G H P A T G E G C R P A S Q S F T P G L I I L A F
Core with dehydrations:
Cys Dha L K P D H H L G H P A Dhb G E G Cys R P A Dha Q Dha F Dhb P G L I I L A F

#### antiSMASH-DB 4.0 matches for allorf_0265696_0265836

100.0%
NZ_CP068102.1 and 7 others:
NZ_CP068102.1 Lanthipeptides: allorf_1181119_1181259_lanthipeptide NZ_CP079819.1 Lanthipeptides: allorf_0009043_0009246_lanthipeptide NZ_CP079819.1 Lanthipeptides: allorf_0009043_0009246_lanthipeptide NZ_KI518028.1 Lanthipeptides: allorf_291916_292056_lanthipeptide NZ_KI518028.1 Lanthipeptides: allorf_291916_292056_lanthipeptide NZ_LR134479.1 Lanthipeptides: allorf_0265696_0265836_lanthipeptide NZ_LR134479.1 Lanthipeptides: allorf_0265696_0265836_lanthipeptide
Lanthipeptides: allorf_1181119_1181259_lanthipeptide
1
C S L K P D H H L G H P A T G E G C R P A S Q S F T P G L I I L A F
34
C S L K P D H H L G H P A T G E G C R P A S Q S F T P G L I I L A F
1
C S L K P D H H L G H P A T G E G C R P A S Q S F T P G L I I L A F
34
23.5%
NZ_CP069338.1 and 1 other:
NZ_CP069338.1 Lanthipeptides: allorf_09109175_09109414_lanthipeptide
Lanthipeptides: allorf_09109175_09109414_lanthipeptide
8
H L G H P A T G E G C R P A S Q S F T
26
G P E G P +S F T
7
E F G A P P L K E G N H P C L E S F T
25
23.5%
NZ_SNZH01000011.1:
Lanthipeptides: allorf_218796_219029_lanthipeptide
14
T G E G C R P A S Q S F T
26
T G G C R A S T
1
T G S G C R K A G P S H T
13
with 1 more sequence matches
14.6%
NZ_LIPB01000002.1:
Lanthipeptides: allorf_1135461_1135619_lanthipeptide
11
H P A T G E G C R
19
H P G G C R
10
H P W G G S G C R
18

#### MIBiG 4.0 matches for allorf_0265696_0265836

11.8%
BGC0000580.3 (EGD17355.1):
Lasso peptide: xanthomonin II or xanthomonin I
10
G H P A T G E
16
G P G E
1
G G P L A G E
7
8.8%
BGC0000566.5 (SPy_0738):
LAP: streptolysin S
25
F T P G
28
+T P G
26
Y T P G
29
allorf_0265791_0265895
Leader:
MFLHPARRLLIGG
Core:
G L L G V P S C A G G A F A P Y L L R V P
Core with dehydrations:
G L L G V P Dha Cys A G G A F A P Y L L R V P

#### antiSMASH-DB 4.0 matches for allorf_0265791_0265895

100.0%
NZ_CP068102.1 and 5 others:
NZ_CP068102.1 Lanthipeptides: allorf_1181060_1181164_lanthipeptide NZ_CP079819.1 Lanthipeptides: allorf_0009138_0009242_lanthipeptide NZ_CP079819.1 Lanthipeptides: allorf_0009138_0009242_lanthipeptide NZ_LR134479.1 Lanthipeptides: allorf_0265791_0265895_lanthipeptide NZ_LR134479.1 Lanthipeptides: allorf_0265791_0265895_lanthipeptide
Lanthipeptides: allorf_1181060_1181164_lanthipeptide
1
G L L G V P S C A G G A F A P Y L L R V P
21
G L L G V P S C A G G A F A P Y L L R V P
1
G L L G V P S C A G G A F A P Y L L R V P
21
26.9%
NC_014483.2 and 23 others:
NC_014622.2 Lanthipeptides: PPSC2_RS36205_lanthipeptide NC_017542.1 Lanthipeptides: PPM_RS07465_lanthipeptide NZ_CP006872.1 Lanthipeptides: PPSQR21_RS07740_lanthipeptide NZ_CP023711.1 Lanthipeptides: CPY53_RS22235_lanthipeptide NZ_CP025957.1 Lanthipeptides: C1A50_RS07530_lanthipeptide NZ_CP029370.1 Lanthipeptides: DI243_RS07495_lanthipeptide NZ_CP040829.1 Lanthipeptides: FGY93_RS00500_lanthipeptide NZ_CP049598.1 Lanthipeptides: G7L40_RS00115_lanthipeptide NZ_CP061172.1 Lanthipeptides: IAQ67_RS07480_lanthipeptide NZ_CP073682.1 Lanthipeptides: KAI36_RS07745_lanthipeptide NZ_CP084033.1 Lanthipeptides: LAZ93_RS07550_lanthipeptide NZ_CP085682.1 Lanthipeptides: LJR53_RS07370_lanthipeptide NZ_CP086373.1 Lanthipeptides: LMH85_RS07780_lanthipeptide NZ_CP092779.1 Lanthipeptides: MJ749_RS07440_lanthipeptide NZ_CP097766.1 Lanthipeptides: MF620_RS07485_lanthipeptide NZ_CP102865.1 Lanthipeptides: NWS42_RS21195_lanthipeptide NZ_CP109848.1 Lanthipeptides: OF859_RS22650_lanthipeptide NZ_CP113973.1 Lanthipeptides: OYT09_RS07785_lanthipeptide NZ_JAAMNR010000001.1 Lanthipeptides: G9G54_RS03500_lanthipeptide NZ_JWJJ01000002.1 Lanthipeptides: U707_RS10390_lanthipeptide NZ_PNXQ01000013.1 Lanthipeptides: C1I60_RS14430_lanthipeptide NZ_POVS01000009.1 Lanthipeptides: C1T21_RS10630_lanthipeptide NZ_POVT01000009.1 Lanthipeptides: C1T20_RS05900_lanthipeptide
Lanthipeptides: PPE_RS07020_lanthipeptide
1
G L L G V P S C A G G A F
13
G L+ P S C A G
2
G L I C T P S C A T G T L
14
23.1%
NC_023037.2 and 6 others:
NZ_CP017967.2 Lanthipeptides: PPYC1_RS07755_lanthipeptide NZ_CP017968.3 Lanthipeptides: PPYC2_RS08330_lanthipeptide NZ_CP073683.1 Lanthipeptides: KAI37_RS07495_lanthipeptide NZ_FOYG01000001.1 Lanthipeptides: BM358_RS03525_lanthipeptide NZ_JAKVDC010000001.1 Lanthipeptides: MKN04_RS02755_lanthipeptide NZ_PTJM01000020.1 Lanthipeptides: C5G87_RS02825_lanthipeptide
Lanthipeptides: X809_RS07820_lanthipeptide
1
G L L G V P S C A G G A F
13
G++ P S C A G
2
G I I C T P S C A T G T L
14
with 2 more sequence matches
15.7%
NZ_WWJS01000019.1:
Lanthipeptides: GT018_RS20925_lanthipeptide
1
G L L G V P S C A G G A F A P Y
16
G V P +G G A P Y
5
G C Q S V P D Q S G G V V A P Y
20
14.3%
NC_017765.1 and 1 other:
NZ_KQ948355.1 Lanthipeptides: AQJ11_RS50945_lanthipeptide
Lanthipeptides: SHJG_RS52475_lanthipeptide
5
V P S C A G G A F A P Y
16
V P+C A G G P+
33
V P A C A G G I A R P F
44

#### MIBiG 4.0 matches for allorf_0265791_0265895

19.0%
BGC0000503.5 (cinA):
Lanthipeptide: cinnamycin
7
S C A G G A F A
14
S C+ G F
4
S C S F G P F T
11
allorf_0269996_0270211
Leader:
MEIMMRTYCILPRWFDTVEGLARVAISLLQGRELIVGVLLRMQRMDSIESFRKLILGS
Core:
Y C V I G T V L H S H I S
Core with dehydrations:
Y Cys V I G Dhb V L H Dha H I Dha

#### antiSMASH-DB 4.0 matches for allorf_0269996_0270211

100.0%
NZ_CP068102.1 and 7 others:
NZ_CP068102.1 Lanthipeptides: allorf_1176779_1176994_lanthipeptide NZ_CP079819.1 Lanthipeptides: allorf_0013342_0013557_lanthipeptide NZ_CP079819.1 Lanthipeptides: allorf_0013342_0013557_lanthipeptide NZ_KI518028.1 Lanthipeptides: allorf_295232_295447_lanthipeptide NZ_KI518028.1 Lanthipeptides: allorf_295232_295447_lanthipeptide NZ_LR134479.1 Lanthipeptides: allorf_0269996_0270211_lanthipeptide NZ_LR134479.1 Lanthipeptides: allorf_0269996_0270211_lanthipeptide
Lanthipeptides: allorf_1176779_1176994_lanthipeptide
1
Y C V I G T V L H S H I S
13
Y C V I G T V L H S H I S
1
Y C V I G T V L H S H I S
13
24.0%
NZ_JACHNX010000043.1:
Lanthipeptides: allorf_0139_0258_lanthipeptide
2
C V I G T V L H S H
11
C V I G H S
16
C V I G E A D H S E
25
10.3%
NZ_CP045142.1:
Lanthipeptides: GBQ70_RS07075_lanthipeptide
1
Y C V I G T V L H S H I S
13
Y C T L H H S
40
Y C D T P T R L H R H E S
52
allorf_0270096_0270281
Leader:
MLCALIALYYG
Core:
H H I T K W C D I K W K L R I C E S V K L F L S H N R S P I S A F G S S Q C Y P F F A S S I E H P Q
Core with dehydrations:
H H I Dhb K W Cys D I K W K L R I Cys E Dha V K L F L Dha H N R Dha P I Dha A F G Dha Dha Q Cys Y P F F A Dha Dha I E H P Q

#### antiSMASH-DB 4.0 matches for allorf_0270096_0270281

100.0%
NZ_KI518028.1 and 3 others:
NZ_KI518028.1 Lanthipeptides: allorf_295332_295517_lanthipeptide NZ_LR134479.1 Lanthipeptides: allorf_0270096_0270281_lanthipeptide NZ_LR134479.1 Lanthipeptides: allorf_0270096_0270281_lanthipeptide
Lanthipeptides: allorf_295332_295517_lanthipeptide
1
H H I T K W C D I K W K L R I C E S V K L F L S H N R S P I S A F G S S Q C Y P F F A S S I E H P Q
50
H H I T K W C D I K W K L R I C E S V K L F L S H N R S P I S A F G S S Q C Y P F F A S S I E H P Q
1
H H I T K W C D I K W K L R I C E S V K L F L S H N R S P I S A F G S S Q C Y P F F A S S I E H P Q
50
98.0%
NZ_CP068102.1 and 1 other:
NZ_CP068102.1 Lanthipeptides: allorf_1176709_1176894_lanthipeptide
Lanthipeptides: allorf_1176709_1176894_lanthipeptide
1
H H I T K W C D I K W K L R I C E S V K L F L S H N R S P I S A F G S S Q C Y P F F A S S I E H P Q
50
H H I T K W C D I K W K L R I C E S V K L F L S H N R S P I S A F G S S+C Y P F F A S S I E H P Q
1
H H I T K W C D I K W K L R I C E S V K L F L S H N R S P I S A F G S S R C Y P F F A S S I E H P Q
50
12.0%
NZ_JAMDLZ010000027.1:
Lanthipeptides: M5W82_RS15515_lanthipeptide
5
K W C D I K W K L R I C
16
K W C + W+ I C
13
K W C T L T W E C S I C
24
with 3 more sequence matches
12.0%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS00795_lanthipeptide
Lanthipeptides: B2C77_RS00795_lanthipeptide
5
K W C D I K W K L R I C E S
18
K W C + W+ I C +
14
K W C T V T W E C S I C P T
27
10.0%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04105_lanthipeptide
Lanthipeptides: MFF31_RS04105_lanthipeptide
5
K W C D I K W K L R I C E S V K L F
22
K+C + W+ +C ++ F
13
K Y C T L T W E C S V C P T L T C F
30
10.0%
NZ_CP013979.1:
Lanthipeptides: ATC03_RS01475_lanthipeptide
26
N R S P I S A F G S S Q C Y P F F A S
44
+P+ F G C P+++
1
G T N P L G T F G C C W C V P W W S G
19
allorf_0270410_0270481
Leader:
MVENRDLASS
Core:
S P K H S T I K N C S R K
Core with dehydrations:
Dha P K H Dha Dhb I K N Cys Dha R K

#### antiSMASH-DB 4.0 matches for allorf_0270410_0270481

100.0%
NZ_LR134479.1 and 1 other:
NZ_LR134479.1 Lanthipeptides: allorf_0270410_0270481_lanthipeptide
Lanthipeptides: allorf_0270410_0270481_lanthipeptide
1
S P K H S T I K N C S R K
13
S P K H S T I K N C S R K
1
S P K H S T I K N C S R K
13
92.3%
NZ_CP079819.1 and 3 others:
NZ_CP079819.1 Lanthipeptides: allorf_0013756_0013827_lanthipeptide NZ_KI518028.1 Lanthipeptides: allorf_295646_295717_lanthipeptide NZ_KI518028.1 Lanthipeptides: allorf_295646_295717_lanthipeptide
Lanthipeptides: allorf_0013756_0013827_lanthipeptide
1
S P K H S T I K N C S R K
13
S P K H S I K N C S R K
1
S P K H S A I K N C S R K
13
84.6%
NZ_CP068102.1 and 1 other:
NZ_CP068102.1 Lanthipeptides: allorf_1176509_1176580_lanthipeptide
Lanthipeptides: allorf_1176509_1176580_lanthipeptide
1
S P K H S T I K N C S R K
13
S P K+S I K N C S R K
1
S P K Y S A I K N C S R K
13

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Lasso peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Each core peptide shows the leader and core peptide sequences.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
Lassopeptides - No core peptides found.
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.03 out of 29.72
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.39 out of 27.78
Confidence: medium
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 16.08 out of 18.57
Confidence: medium
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 24.59 out of 29.72
Confidence: medium
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 20.10 out of 21.84
Confidence: medium
Additional weak hits (12):
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.92 out of 27.78
Confidence: weak
CsoR
Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 22.24 out of 32.38
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.27 out of 20.01
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 17.92 out of 26.06
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 18.15 out of 28.14
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.87 out of 29.38
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 20.75 out of 31.73
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 21.44 out of 36.54
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.97 out of 32.93
Confidence: weak
RicR
Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 22.72 out of 32.93
Confidence: weak
CsoR
Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 21.84 out of 32.38
Confidence: weak
Lanthipeptides
Lasso peptides
RREFinder
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

EL250_RS01320 - Class II
  Cleavage pHMM score: 4.70
  RODEO score: 0
  Monoisotopic mass: 4591.8 Da
  Molecular weight: 4594.7 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4612.7 Da N = 1
    4630.7 Da N = 2
    4648.7 Da N = 3
    4666.7 Da N = 4
    4684.8 Da N = 5
    4702.8 Da N = 6
    4720.8 Da N = 7
    4738.8 Da N = 8
    4756.8 Da N = 9
EL250_RS01330 - Class II
  Cleavage pHMM score: 3.20
  RODEO score: 0
  Monoisotopic mass: 3620.4 Da
  Molecular weight: 3622.7 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3640.7 Da N = 1
    3658.8 Da N = 2
    3676.8 Da N = 3
    3694.8 Da N = 4
allorf_0261182_0261298 - Class II
  Cleavage pHMM score: -5.20
  RODEO score: 0
  Monoisotopic mass: 3207.8 Da
  Molecular weight: 3209.7 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3227.7 Da N = 1
allorf_0265595_0265780 - Class II
  Cleavage pHMM score: -7.00
  RODEO score: 0
  Monoisotopic mass: 5038.6 Da
  Molecular weight: 5041.9 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    5059.9 Da N = 1
    5077.9 Da N = 2
    5095.9 Da N = 3
    5114.0 Da N = 4
allorf_0265627_0265695 - Class II
  Cleavage pHMM score: -7.30
  RODEO score: 0
  Monoisotopic mass: 1044.5 Da
  Molecular weight: 1045.1 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1063.1 Da N = 1
allorf_0265696_0265836 - Class II
  Cleavage pHMM score: -6.10
  RODEO score: 0
  Monoisotopic mass: 3466.8 Da
  Molecular weight: 3468.9 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3487.0 Da N = 1
    3505.0 Da N = 2
    3523.0 Da N = 3
allorf_0265791_0265895 - Class II
  Cleavage pHMM score: -6.00
  RODEO score: 0
  Monoisotopic mass: 2039.1 Da
  Molecular weight: 2040.4 Da
  Number of bridges: 1
allorf_0269996_0270211 - Class II
  Cleavage pHMM score: -4.70
  RODEO score: 0
  Monoisotopic mass: 1373.7 Da
  Molecular weight: 1374.6 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1392.6 Da N = 1
    1410.6 Da N = 2
allorf_0270096_0270281 - Class II
  Cleavage pHMM score: -6.10
  RODEO score: 0
  Monoisotopic mass: 5695.9 Da
  Molecular weight: 5699.5 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    5717.5 Da N = 1
    5735.6 Da N = 2
    5753.6 Da N = 3
    5771.6 Da N = 4
    5789.6 Da N = 5
    5807.6 Da N = 6
allorf_0270410_0270481 - Class II
  Cleavage pHMM score: -6.40
  RODEO score: 0
  Monoisotopic mass: 1412.8 Da
  Molecular weight: 1413.6 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1431.7 Da N = 1
    1449.7 Da N = 2
    1467.7 Da N = 3
EL250_RS01320 - Class II
  Cleavage pHMM score: 4.70
  RODEO score: 0
  Monoisotopic mass: 4591.8 Da
  Molecular weight: 4594.7 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4612.7 Da N = 1
    4630.7 Da N = 2
    4648.7 Da N = 3
    4666.7 Da N = 4
    4684.8 Da N = 5
    4702.8 Da N = 6
    4720.8 Da N = 7
    4738.8 Da N = 8
    4756.8 Da N = 9
EL250_RS01330 - Class II
  Cleavage pHMM score: 3.20
  RODEO score: 0
  Monoisotopic mass: 3620.4 Da
  Molecular weight: 3622.7 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3640.7 Da N = 1
    3658.8 Da N = 2
    3676.8 Da N = 3
    3694.8 Da N = 4
allorf_0265595_0265780 - Class II
  Cleavage pHMM score: -7.00
  RODEO score: 0
  Monoisotopic mass: 5038.6 Da
  Molecular weight: 5041.9 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    5059.9 Da N = 1
    5077.9 Da N = 2
    5095.9 Da N = 3
    5114.0 Da N = 4
allorf_0265627_0265695 - Class II
  Cleavage pHMM score: -7.30
  RODEO score: 0
  Monoisotopic mass: 1044.5 Da
  Molecular weight: 1045.1 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1063.1 Da N = 1
allorf_0265696_0265836 - Class II
  Cleavage pHMM score: -6.10
  RODEO score: 0
  Monoisotopic mass: 3466.8 Da
  Molecular weight: 3468.9 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3487.0 Da N = 1
    3505.0 Da N = 2
    3523.0 Da N = 3
allorf_0265791_0265895 - Class II
  Cleavage pHMM score: -6.00
  RODEO score: 0
  Monoisotopic mass: 2039.1 Da
  Molecular weight: 2040.4 Da
  Number of bridges: 1
allorf_0269996_0270211 - Class II
  Cleavage pHMM score: -4.70
  RODEO score: 0
  Monoisotopic mass: 1373.7 Da
  Molecular weight: 1374.6 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1392.6 Da N = 1
    1410.6 Da N = 2
allorf_0270096_0270281 - Class II
  Cleavage pHMM score: -6.10
  RODEO score: 0
  Monoisotopic mass: 5695.9 Da
  Molecular weight: 5699.5 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    5717.5 Da N = 1
    5735.6 Da N = 2
    5753.6 Da N = 3
    5771.6 Da N = 4
    5789.6 Da N = 5
    5807.6 Da N = 6
allorf_0270410_0270481 - Class II
  Cleavage pHMM score: -6.40
  RODEO score: 0
  Monoisotopic mass: 1412.8 Da
  Molecular weight: 1413.6 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1431.7 Da N = 1
    1449.7 Da N = 2
    1467.7 Da N = 3

Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of disulfide bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.
No core peptides found.
RRE predictions
RREfinder results sidepanel.

lassopeptide protocluster (246014...268341)
EL250_RS01255
  RRE type: Stand_Alone_Lasso_RRE
  Location: 14 - 94
  Score: 38.9

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MexT | Global virulence regulator
NtrC | Nitrogen regulatory protein C
ToxT | Regulator of MSHA biosynthesis

NZ_LR134479.1 - Region 2 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 867,370 - 888,503 nt. (total: 21,134 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
EL250_RS03780: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: acyltransferase
EL250_RS03795: acyltransferase

smcogs
  SMCOG1141: acyltransferase

Ligases: ligase synthetase
EL250_RS03785: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

EL250_RS03815: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002193.2 |  | 0.56 | other (other) | phenguignardic acid | Aspergillus terreus NIH2624
BGC0000677.5 |  | 0.42 | terpene | cyclooctatin | Streptomyces melanosporofaciens
BGC0000649.3 |  | 0.40 | terpene | carotenoid | Streptomyces griseus subsp. griseus NBRC 13350
BGC0002561.3 |  | 0.40 | other (other) | phenazine SA, phenazine SB, phenazine SC | Streptomyces sp.
BGC0000597.4 |  | 0.39 | ribosomal | SWA-2138 | Streptomyces sp. e14
BGC0001910.4 |  | 0.39 | terpene | cyslabdan A, cyslabdan B, cyslabdan C | Streptomyces cyslabdanicus
BGC0000595.3 |  | 0.39 | ribosomal | SCO-2138 | Streptomyces coelicolor A3(2)
BGC0000664.5 |  | 0.39 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001456.3 |  | 0.38 | terpene | isorenieratene | Streptomyces argillaceus
BGC0001911.3 |  | 0.38 | terpene | raimonol | Streptomyces anulatus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002193.2 |  | 0.56 | other (other) | phenguignardic acid | Aspergillus terreus NIH2624
BGC0000677.5 |  | 0.42 | terpene | cyclooctatin | Streptomyces melanosporofaciens
BGC0000649.3 |  | 0.40 | terpene | carotenoid | Streptomyces griseus subsp. griseus NBRC 13350
BGC0002561.3 |  | 0.40 | other (other) | phenazine SA, phenazine SB, phenazine SC | Streptomyces sp.
BGC0000597.4 |  | 0.39 | ribosomal | SWA-2138 | Streptomyces sp. e14
BGC0001910.4 |  | 0.39 | terpene | cyslabdan A, cyslabdan B, cyslabdan C | Streptomyces cyslabdanicus
BGC0000595.3 |  | 0.39 | ribosomal | SCO-2138 | Streptomyces coelicolor A3(2)
BGC0000664.5 |  | 0.39 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001456.3 |  | 0.38 | terpene | isorenieratene | Streptomyces argillaceus
BGC0001911.3 |  | 0.38 | terpene | raimonol | Streptomyces anulatus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
EL250_RS03815: PT_FPPS_like
Domain 1 (54 - 372): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 16.04 out of 18.57
Confidence: medium
Additional weak hits (8):
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.03 out of 23.43
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.41 out of 25.75
Confidence: weak
RicR
Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.87 out of 32.93
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.65 out of 39.62
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.44 out of 26.06
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.59 out of 36.54
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 21.44 out of 36.54
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.83 out of 27.78
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ToxT | Regulator of MSHA biosynthesis

NZ_LR134479.1 - Region 3 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,575,724 - 1,619,980 nt. (total: 44,257 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
EL250_RS06845: 3-hydroxyisobutyrate dehydrogenase

smcogs
  SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

Transferases: formyltransferase transketolase
EL250_RS06855: transketolase

smcogs
  SMCOG1204: transketolase

EL250_RS06930: methionyl-tRNA formyltransferase

smcogs
  SMCOG1228: methionyl-tRNA formyltransferase

Hydrolases: deformylase esterase
EL250_RS06885: enterobactin/ferric enterobactin esterase

smcogs
  SMCOG1098: enterobactin/ferric enterobactin esterase

EL250_RS06935: peptide deformylase

smcogs
  SMCOG1275: peptide deformylase

Ligases: ligase synthase
EL250_RS06830: cysteine synthase

smcogs
  SMCOG1081: cysteine synthase

EL250_RS06880: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002685.2 |  | 0.79 | NRPS | enterobactin | Rothia mucilaginosa ATCC 25296
BGC0002075.3 |  | 0.74 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0001833.4 |  | 0.67 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  | 0.67 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001132.4 |  | 0.66 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001758.4 |  | 0.66 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001641.4 |  | 0.64 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  | 0.63 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001135.5 |  | 0.63 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001261.3 |  | 0.63 | NRPS | AM-toxin | Alternaria alternata

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002685.2 |  | 0.79 | NRPS | enterobactin | Rothia mucilaginosa ATCC 25296
BGC0002075.3 |  | 0.74 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0001833.4 |  | 0.67 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  | 0.67 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001132.4 |  | 0.66 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001758.4 |  | 0.66 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001641.4 |  | 0.64 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  | 0.63 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001135.5 |  | 0.63 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001261.3 |  | 0.63 | NRPS | AM-toxin | Alternaria alternata

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.19 out of 20.47
Confidence: strong
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.91 out of 23.79
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.16 out of 30.25
Confidence: medium
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 21.40 out of 23.05
Confidence: strong
Additional weak hits (6):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.47 out of 29.38
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.95 out of 39.62
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.00 out of 26.06
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.22 out of 25.75
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.90 out of 30.98
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 19.56 out of 28.14
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 5, location 1575723 - 1619980:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Ser)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
EL250_RS06870: Ser
Search NORINE for peptide: strict or relaxed
AMP-binding (515..966): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    ser (Ser)
  Single AA prediction:
    ser (Ser)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWQTFDVHVWEWHFVCSGELNLYGPTEAAVDVTF
  Nearest Stachelhaus code(s):
    Ser DVWHVSLVDK (88% 8Å match)
  Stachelhaus code match:
    100% (strong)

EL250_RS06880: diOH-Bz
Search NORINE for peptide: strict or relaxed
AMP-binding (50..465): diOH-Bz
nrpys: diOH-Bz

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Small clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Single AA prediction:
    dhb (diOH-Bz)

Stachelhaus prediction details:
  Stachelhaus sequence:
    SGSLFTMSSPGGALQVGGAQQVFGMAEGLVNYTR
  Nearest Stachelhaus code(s):
    diOH-Bz TMPSQGVVNK (94% 8Å match)
  Stachelhaus code match:
    90% (moderate)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
ColR | Phenol-responsive regulator
IolR | Regulator of the inositol catabolism
VqsM | Regulator of quorum-sensing signalling systems