LOCUS       NZ_LR134263            10291 bp    DNA     circular CON 05-APR-2024
DEFINITION  Staphylococcus delphini strain NCTC12225 chromosome 1, complete
            sequence.
ACCESSION   NZ_LR134263
VERSION     NZ_LR134263.1
KEYWORDS    RefSeq.
SOURCE      Staphylococcus delphini
  ORGANISM  Staphylococcus delphini
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus; Staphylococcus intermedius group.
REFERENCE   1  (bases 1 to 2798161)
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (18-DEC-2018) WTSI, Pathogen Informatics, Wellcome Trust
            Sanger Institute, CB10 1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900636325.1-RS_2024_04_05
            Annotation Date                   :: 04/05/2024 03:36:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,651
            CDSs (total)                      :: 2,569
            Genes (coding)                    :: 2,507
            CDSs (with protein)               :: 2,507
            Genes (RNA)                       :: 82
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 62
            CDSs (without protein)            :: 62
            Pseudo Genes (ambiguous residues) :: 0 of 62
            Pseudo Genes (frameshifted)       :: 22 of 62
            Pseudo Genes (incomplete)         :: 40 of 62
            Pseudo Genes (internal stop)      :: 16 of 62
            Pseudo Genes (multiple problems)  :: 13 of 62
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:43:04
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2739041
            Orig. end                         :: 2749332
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LR134263.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10291
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="9"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10291
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10291
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5291](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5291)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            160..1551
                     /locus_tag="EL101_RS12875"
                     /old_locus_tag="NCTC12225_02653"
     CDS             160..1551
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015293 - symporter activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1212:
                     sodium:dicarboxylate symporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015728531.1"
                     /locus_tag="EL101_RS12875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12225_02653"
                     /product="cation:dicarboxylase symporter family
                     transporter"
                     /protein_id="WP_096595866.1"
                     /transl_table=11
                     /translation="MSIFLIIINLIIFLLALLSLWVMAKKHVKFPKRVFFALGLGIVLG
                     LLLHLIYGVEGQVTTQTTDWVGLIGNGYIALLQMIVIPLIFVSIVAAFTKIEIGEKFAK
                     VGSLIFMFLIGTVTIAAIIGIIYALAFNLDASSIDLGQAENARSAEITDKAKGLTATTL
                     PTQILELLPSNPFLDFTGARATSTIAVVIFAAFVGFAFLRVARKQPENGQTLKRGIDAI
                     YALVMAIVTFVLRLTPYGILAIMINTIATSDFAAIWTLGKFVIASYAALITMYIIHLII
                     LAVIGVNPVHYVKKTAEVILFAFTSRSSAGTLPLNVQAQTNRLGVPQAIANFSGSFGLS
                     IGQNGCAGIYPAMLAIMVAPVAGVEVNLQFIVTVIIVVVLSSFGVAGVGGGATFASILV
                     LSALNLPVGLAGVLISVEPLIDMGRTALNVNDSILAGTGTAKLTKQLDEDIFHSNYMDE
                     LTAQH"
     misc_feature    171..184
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 23.9"
                     /tool="antismash"
     gene            complement(2023..2679)
                     /locus_tag="EL101_RS12880"
                     /old_locus_tag="NCTC12225_02654"
     CDS             complement(2023..2679)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015728530.1"
                     /locus_tag="EL101_RS12880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12225_02654"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_096595867.1"
                     /transl_table=11
                     /translation="MIELKNVTIQKGKRTIFDNVNLTFEPGKSYALIGHSGSGKSTLLN
                     AIAGFETLKQGEVRFDQKRLKADFRFYRDILGYVFQNYGLVDSMTINQNLDMALAFKKV
                     SKSERQQLKTQCLQKVGIDMNHKRKVATLSGGEQQRVALARLLLKQPRLILADEPTGSL
                     DDANGQKVVELLFEMVDERRILIIATHDLALAQRCDEIIQVDALKCHSSELETVQ"
     gene            complement(2676..3005)
                     /locus_tag="EL101_RS12885"
                     /old_locus_tag="NCTC12225_02655"
     CDS             complement(2676..3005)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014614906.1"
                     /locus_tag="EL101_RS12885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12225_02655"
                     /product="YxeA family protein"
                     /protein_id="WP_096595868.1"
                     /transl_table=11
                     /translation="MKKNMLISIAVIVIGCVLFLAFVRLTYVDYFNPFLKKETSYAVVP
                     LGTQTYVDIQAYDESGEPLKYRLNFGGYDAKSDHVKVIHKGKYVFEIEYIHDLSKWPKE
                     VKKKE"
     gene            complement(3009..4976)
                     /locus_tag="EL101_RS12890"
                     /old_locus_tag="NCTC12225_02656"
     CDS             complement(3009..4976)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014614907.1"
                     /locus_tag="EL101_RS12890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12225_02656"
                     /product="DUF1430 domain-containing protein"
                     /protein_id="WP_096595869.1"
                     /transl_table=11
                     /translation="MKWMKHLLDVVTLTLISLFLILVLYEEDSEILTGSRVMLEVESWD
                     YQHSKAEVFEKFEKVAKDADIAIFKVVIDHKEHQVDKAIYAFNEQANHHTIAPMNTTYS
                     YHHLTHDQLMQRDVRGDYFILDDIANKEQLKTALESVGLKVRMGSVQSWMIYGDVLINR
                     GVLLPFVTLLIIYLLYHLHYRSQNFKTYATMRLHGYRFFNILFLNIEKIIIRWLILAIS
                     VGFLSIGLLKWLGLDGQLEYFVSRLIVADILFWGILSISSLLSCIILIRIDIPLMIKGL
                     KPYRLLRAMNHISKLSMLVLLTLLILPNLNQMKKLEQIQETEAWWGKLDDYYTIDLKPI
                     RRSMNEEMEFAKRYHQMFIYSERHEQALLMNQNVLYEPSQTNYSPDEGNVLFVNQNFVD
                     FFKSQLRELPNLEDRPGQIELYLPPQAKNEVSAIRADFQDWVNYQLPNPESKTKVLVTQ
                     LKNPYEIYAFDVRTGLSTTYMKSPAILMLNAKDLTDDFYYSTLSQGELIFKNYENIIRN
                     IDRFDLKDDVQGVTNYKDSVMKTYRETQTKWLVYSFSSGIAMTVLCIVTLLDVLHYFEQ
                     RRQWLLMRKMFGFRRWQNYRNYIVLNGLFTALIGAFLFEKTQNSNVIWIFGVILLFQFF
                     IQWVYIHYLEKQFNVLIREA"
     gene            complement(5001..5291)
                     /locus_tag="EL101_RS12895"
                     /old_locus_tag="NCTC12225_02657"
     CDS             complement(5001..5291)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Lactococcin_972"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019166953.1"
                     /locus_tag="EL101_RS12895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12225_02657"
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="WP_096595870.1"
                     /sec_met_domain="Lactococcin_972 (E-value: 1.3e-18,
                     bitscore: 64.6, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNKILSTLVAGLLLIGIGSSSIVSAATIYTDGGTWNYGVGSKYV
                     WSYYSNNYRYHSSTAIGKTRSFSGFRKPGVRALASSEKRWWWRNEAYYNVY"
     misc_feature    5464..5473
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 15.78"
                     /tool="antismash"
     gene            complement(5496..6251)
                     /gene="nfsA"
                     /locus_tag="EL101_RS12900"
                     /old_locus_tag="NCTC12225_02658"
     CDS             complement(5496..6251)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="nfsA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00881"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011276836.1"
                     /locus_tag="EL101_RS12900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12225_02658"
                     /product="oxygen-insensitive NADPH nitroreductase"
                     /protein_id="WP_096595871.1"
                     /sec_met_domain="PF00881 (E-value: 4.9e-20, bitscore: 69.5,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEYVYDLAKRHHSVRKFKQTPIERATIEKLIEAGQMASTSSFLQ
                     TTSFIGVESVEKKEALREVSGQPYVVENGYLLVYVIDYHRHQLINEKMKADMEASFESA
                     EGLLVGTVDAALAAQNIALTAEDMGYGIVYLGSLRNDVQRVREILNLPEHVFPLFGMAI
                     GEPADDENGSPKPRLPLSHVFHVDTYNQDDAELSEQIEAYDQTVSEYYQERTQGKRDET
                     WSDQIAGFMSSKQRLEMNDWLQMSGFNKK"
     misc_feature    complement(6385..6405)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 25.21"
                     /tool="antismash"
     misc_feature    complement(6430..6444)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 22.15"
                     /tool="antismash"
     misc_feature    6716..6729
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     medium, score: 24.83"
                     /tool="antismash"
     gene            6807..7376
                     /gene="ahpC"
                     /locus_tag="EL101_RS12905"
                     /old_locus_tag="NCTC12225_02659"
     CDS             6807..7376
                     /EC_number="1.11.1.26"
                     /GO_function="GO:0102039 - NADH-dependent peroxiredoxin
                     activity [Evidence IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ahpC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1196: alkyl hydroperoxide reductase/ Thiol specific"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002445177.1"
                     /locus_tag="EL101_RS12905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12225_02659"
                     /product="alkyl hydroperoxide reductase subunit C"
                     /protein_id="WP_096539709.1"
                     /transl_table=11
                     /translation="MSLIGKQIEEFSAQAYNAKTDEFIEVTHEDLKGNWSVVVFYPADF
                     SFVCPTELEDVQNHYEKLQELGTNVFSVSTDTHFVHKAWHDHSDAISKLQYTMIGDPSQ
                     AITRQFDVLDETSGLAQRGTFIVDPDGVVQAAEINADGIGRDASTLVHKIKAAQYVRQN
                     PGEVCPAKWEEGSETLTPGLDLVGKI"
     gene            7391..8914
                     /gene="ahpF"
                     /locus_tag="EL101_RS12910"
                     /old_locus_tag="NCTC12225_02660"
     CDS             7391..8914
                     /GO_function="GO:0016668 - oxidoreductase activity, acting
                     on a sulfur group of donors, NAD(P) as acceptor [Evidence
                     IEA]"
                     /GO_process="GO:0006805 - xenobiotic metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0009398 - FMN biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ahpF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1176: alkyl hydroperoxide reductase subunit"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000930502.1"
                     /locus_tag="EL101_RS12910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12225_02660"
                     /product="alkyl hydroperoxide reductase subunit F"
                     /protein_id="WP_096595872.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.1e-41, bitscore:
                     140.2, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLNQELKQQLSQLLDLMEGDVVLKVSTGDDDHSQKMNDLVNEVSD
                     MSSRITVEKAELKRTPSFSINRPNEDTGITFAGVPLGHEFNSFVLALLQVSGRAPKEEQ
                     SVIDQIKSINEPLHFETFISLTCQKCPDVVQALNLMSVINPNITHTMIDGAVFKKEAED
                     IMAVPAIFLNGEQFGNGRMTVTDILSALGQGPDASEFENKETFDVLVVGGGPASASSAI
                     YAARKGLKTGIVADRIGGQVNDTADIENLIGVKKTTGPSLATSLEAHIKDYNVDAMTGV
                     RAEGLEKSDDIVHLTLDNGAVLKTRSLIIATGARWKKIGVPGEDTFANKGVAYCPHCDG
                     PLFEGKDVAVIGGGNSGVEAAIDLAGICKSVTVLEFGESLKADSVLQDRLNSLPNTTVI
                     TQAATKEITGDDRVNGLTYTDRATDEEKHVDLNGVFVQIGLSPNTEWLGDTVQRNRMGE
                     IEVDRLGNTNIPGVFAAGDCTDQRYKQIIISMGSGATAALSAFDYLIRN"
     misc_feature    9745..9760
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.01"
                     /tool="antismash"
ORIGIN
        1 acaactgatg gcacaactcg ttgacgagga tagcgaagcc caacgtcagc tcgctccatt
       61 tacacctaaa attaagcaaa tataaaaaat atatcttgat tttacgtttc cttactatta
      121 tcctattata taagtcggaa ttaaaaagga agcgtatgta tgtctatatt tttaattatt
      181 attaacttaa ttatttttct tctcgcctta ttgagcctgt gggtgatggc gaaaaaacat
      241 gtcaaattcc ctaaacgtgt gttctttgcg ctaggtttag gtatcgtatt aggcctcctc
      301 ctccacctca tttatggcgt tgaaggtcaa gtgacgacac aaacaactga ttgggtcggc
      361 ttaattggga atgggtatat tgcattgcta caaatgattg tcattccact gatttttgtt
      421 tctatcgtcg cggcatttac gaaaattgaa attggagaaa agtttgctaa agtcggcagc
      481 ttaatcttca tgtttttgat tggtaccgta acgattgcag cgattatcgg tattatctat
      541 gcactcgcat tcaatttaga tgcttctagt attgacttag gtcaggcaga aaatgctcgt
      601 agcgccgaaa ttactgataa agcgaaaggg cttactgcaa caacattgcc aacacaaatt
      661 ttagaattgt taccgtcaaa tccattttta gatttcactg gtgcacgtgc aacttctact
      721 attgcagtcg tgatctttgc cgcatttgta ggctttgcat ttttacgtgt cgcacgtaaa
      781 caacctgaaa atggtcaaac tttaaaacgc ggtattgatg ccatttacgc acttgtcatg
      841 gctatcgtca catttgtttt acgcctaacg ccttatggga ttttagcgat tatgattaac
      901 acaattgcga cgagtgattt tgctgcgatt tggacactcg gtaagttcgt gattgcgtcg
      961 tatgcagcac tcattacaat gtacatcatt cacctaatca ttttagctgt tattggtgtc
     1021 aatccagtac attatgtgaa gaaaacagcc gaagttattt tattcgcatt cacttcgcgt
     1081 tcaagtgctg gtacattgcc attaaacgta caagcgcaaa cgaatcgtct aggtgtgcct
     1141 caagctatcg caaacttctc gggctcattt ggactatcta tcggacaaaa tggctgtgcg
     1201 ggaatctacc ctgcaatgct tgcaatcatg gtcgcacctg tcgcgggtgt tgaagtgaat
     1261 ctacaattta ttgtgacagt cattatcgtt gtcgtgttaa gttcattcgg tgtagcaggt
     1321 gtagggggcg gtgcaacatt cgcttcaatc ctggtcttat ctgcattgaa cttgccggtc
     1381 ggtcttgcgg gtgtcttaat ttcagtcgag ccactgatcg atatgggtcg tacagcactt
     1441 aacgtgaatg actctatctt agcgggtaca ggcactgcca aactgacaaa acaactcgat
     1501 gaagacattt tccattccaa ttatatggac gaattaaccg cacaacatta agtaacacaa
     1561 tagttacaaa acagtatatg cggatgaact tgccctcttc ctacgattta ttagttctag
     1621 gattgtcttg atggattcgc tttcccaggg gacttgcctc aactagccaa cgcttaatca
     1681 tactgtgaca taagtgaagc gttggcggat tttcggctgc gtctgatccc tcgggagtct
     1741 catccatcac gacaatctta ctctacaaag tcatagaaag agggcaactt tttacattaa
     1801 tgcgatgtaa cttgcttttg atttcatcgt taattacttg ctttattgta aatgagatta
     1861 aagtgtacat ttcgtacata ctgaagctta attttcatag agcgtctaca aagtcaatca
     1921 catatgtata taaacataat caaagagaca gagggcaagt tggctgtgat acgccatttc
     1981 ttttctgcta atattaatgc ccctatctct tttaacttat gtttattgta cggtttctaa
     2041 ttcgctactg tgacatttta gtgcatcaac ttgaataatc tcgtcgcatc gttgggcaag
     2101 tgctaagtca tgagtggcga taatgagtat tcgtctttca tctaccattt caaacaagag
     2161 ttccactact ttctgcccgt tcgcgtcatc taaagagcca gtcggttcat ctgctaaaat
     2221 caggcgcggt tgtttgagca ataaacgcgc taatgctacc cgctgttgct cgcctccact
     2281 taatgtcgca actttacgct tatgattcat atcaatccca accttttgta aacattgtgt
     2341 tttcaattgt tggcgttctg atttggatac tttcttgaaa gccagtgcca tatcgagatt
     2401 ttggttaatc gtcattgaat caacaagacc ataattttga aatacatagc cgaggatatc
     2461 gcgataaaaa cgaaaatcag ctttcaatct tttttgatcg aatcgcacct caccttgttt
     2521 caatgtttcg aatcctgcaa tcgcattcag caaagtcgat ttccctgacc cactatgacc
     2581 aataagcgca taagacttcc ccggttcaaa cgtcaaattc acattgtcaa aaatcgtacg
     2641 tttccctttt tgaatcgtta cattttttaa ttcaatcatt ctttcttctt cacctcttta
     2701 ggccattttg aaaggtcatg aatatattca atctcaaaga cgtatttacc tttgtgaatc
     2761 acttttacat gatcagactt ggcatcatat ccaccgaaat tcaaacgata tttgagtggt
     2821 tcgcccgatt cgtcatacgc ttgaatatcc acatacgttt gtgttcctaa tggtaccacc
     2881 gcataagatg tctccttctt taaaaatgga ttaaagtaat caacatacgt cagacgtaca
     2941 aaagctaaaa atagaacaca cccgatgacg attactgcaa tcgatatcag catatttttc
     3001 ttcaatattt aagcctccct aattagtaca ttgaattgtt tttctaaata atggatgtaa
     3061 acccattgaa tgaagaattg aaacagcaaa atcacgccaa aaatccatat cacattacta
     3121 ttttgtgtct tttcaaataa gaatgcgcca ataagagcag taaataaacc atttaatacg
     3181 atatagttgc gatagttttg ccaacgtctg aagccaaaca tttttcgcat aagtaaccat
     3241 tgacgacgct gctcaaagta atgcaataca tctaataatg tcacgataca caagactgtc
     3301 atagcgatac cactagaaaa gctatacaca agccatttcg tttgtgtttc tcgatacgtt
     3361 ttcataacac tgtctttata attggttaca ccttgcacat catctttcaa atcaaagcgg
     3421 tcgatattac ggataatatt ttcataattt ttaaaaatca attccccttg tgataatgtg
     3481 gaataataaa aatcatccgt taagtcttta gcatttaaca ttaaaatcgc aggcgacttc
     3541 atataggttg tcgacaatcc cgtacgtaca tcaaaggcgt aaatttcgta aggatttttc
     3601 aactgcgtca ctagtacctt tgtctttgat tctggatttg gaagttgata gttcacccaa
     3661 tcctgaaaat ctgcacgtat ggctgagact tcatttttag cttgaggagg taaatacaac
     3721 tctatttgtc caggtcggtc ttctaaattc ggtaactctc gtaattgaga cttaaaaaaa
     3781 tcaacaaagt tttgattgac aaacagcaca tttccttcgt ctggcgaata atttgtttga
     3841 cttggttcat acaatacatt ttgattcatc aataatgctt gttcatgtcg ctcactatat
     3901 ataaacattt gatgatatcg tttcgcaaat tccatttctt cgttcatact acgccgtatg
     3961 ggtttcaagt caattgtgta ataatcatct agtttgcccc accatgcttc tgtctcttgt
     4021 atttgttcta actttttcat ttgattaaga ttcggcaaaa tgaggagtgt gagtaaaact
     4081 aacatactca acttagagat atgattcatc gcacgtaaca gacgatatgg cttgagtcct
     4141 ttaatcatca atgggatatc tatccggata agtatgatac aagacagtaa tgaactgata
     4201 gataaaattc cccaaaataa aatatccgca acgatgagac gacttacaaa atattcgagt
     4261 tgaccgtcca atcctaacca tttcaacagc cctatcgaaa ggaatccgac acttatggct
     4321 aatatcaacc atctgataat aattttttca atattcagaa acaagatatt aaaaaaacga
     4381 taaccatgta aacgcatcgt cgcatatgtt ttaaaatttt gacttcgata atgcaaatga
     4441 tacaacaaat agataataag taatgtcaca aatggaagca gtacgcctcg attaatgagc
     4501 acatccccat agatcatcca tgattgtaca gatcccatcc tcacctttag accgacactt
     4561 tctaaagctg ttttcaattg ttccttatta gcaatatcat ctaatataaa ataatcacca
     4621 cgtacatctc gctgcatcag ttgatcatgc gttaaatgat ggtaactata tgtcgtattc
     4681 atcggcgcaa tagtgtgatg attggcttgc tcattaaacg cataaatcgc tttatcgact
     4741 tgatgttctt tatgatcgat aacgacttta aaaatcgcaa tatctgcatc tttcgctacc
     4801 ttctcaaact tctcaaaaac ttctgctttt gaatgttggt agtcccaact ttcaacttca
     4861 agcatcacac gacttccagt aagtatttcg ctgtcctctt cgtacagtac aagaattaaa
     4921 aataagctta ttagtgtgag cgtgaccaca tctaataagt gtttcatcca cttcattgct
     4981 cacctctata aattggaaac ttagtataca ttataatatg cttcattacg ccaccaccat
     5041 ctcttttctg atgatgccag tgctctaact ccaggttttc taaatccact aaacgatctt
     5101 gttttcccaa ttgctgttga actatggtat ctatagttat tactataata tgaccatacg
     5161 tatttacttc ctacaccata attccaagtt cctccgtcag tatagatagt tgctgcacta
     5221 actatactag acgaaccaat acctattaac aataacccag cgactaaagt actcaaaatc
     5281 ttatttttca taatttcatc ctcctttata ataacattac acctttatta tagtttatac
     5341 caatctgatt ttcaacaata ttaaataaat attttcacct tatttagttt atatatatgt
     5401 gtgtagaaat aaaatacaag gacttcatct ttaatcctaa aaaactcccc atccatttat
     5461 tttgaacggg gagaatttat ttgattatcg atatattatt tcttattaaa tcctgacatt
     5521 tgcaaccaat cattcatctc taatcgttgc ttgctactca taaagccagc gatttgatcg
     5581 gaccatgttt catcacgttt gccttgtgtg cgttcttgat aatattcaga cacagtttga
     5641 tcataagctt caatttgttc agacaattca gcgtcatctt gattgtaagt atccacatgg
     5701 aacacatggg ataatggaag gcgcggttta ggtgaaccat tttcgtcatc tgctggctct
     5761 ccaatggcca taccgaataa tgggaagacg tgttcaggta aatttaaaat ttcgcgtaca
     5821 cgttgcacat cgttacgtaa tgaaccgaga tatacaatgc cgtaacccat atcttcagcc
     5881 gtcaatgcaa tattttgagc cgctaatgcc gcgtcaactg taccgactaa taatccttca
     5941 gctgattcaa agctcgcttc catgtctgct ttcatttttt cattaatcaa ttggtgacga
     6001 tggtaatcaa tcacgtaaac gagcaagtac ccattttcaa cgacataagg ctggcctgaa
     6061 acttctctga gcgcttcttt cttttcaacg gattctacac ctataaatga cgtcgtttgc
     6121 aagaaacttg acgtcgatgc catttgtcct gcttctatta atttttcaat cgttgctcgt
     6181 tcgatcggtg tttgtttgaa ctttctcact gaatgatgtc gcttggccaa atcatacaca
     6241 tattctgaca taaaaaacac tcctaacatc cttttctcta tcgtaacact tgccctacta
     6301 aaacgcatga ttcgtgcatg gttcctagct attatactcg cactttattt aattaacgaa
     6361 aatcacatct gttatgataa tatcaacaaa gcgctttcta tgtttaccct ttaattgaga
     6421 atgaaagcat ataaatgata ttcaaatctt ttatcaatta acttatttcc gtttttttat
     6481 ttccaatgta tcatctgctt tattatcttt actacaataa aaaataatgc ggaacaatca
     6541 tcacatgtga ccaaattgtg atcgaaaagt ggcgttttta ctgtatttag gctttattgc
     6601 acctataaca tcaaaatcgc tattaattat gaaagcgttt aacttcaaat tggataaaaa
     6661 tcttttgtat ttatttgacg taatgattgt tccatgtcat aatactactt gagattagaa
     6721 ttattattaa taaggaatta tcacaaagta aaaacttggt tctaatccaa ataataatga
     6781 ttcatataaa taggaggatt ttgattatgt cattaatcgg taaacaaatt gaggaatttt
     6841 cagcacaagc atacaatgca aaaacagatg aatttattga agttacacac gaagatttaa
     6901 aaggtaactg gagtgttgtc gtattctacc ctgcagattt ctcattcgta tgtccaactg
     6961 aattagaaga tgtacaaaat cattacgaaa aattacaaga gttaggtaca aacgtatttt
     7021 ctgtttctac agatactcac tttgtacata aagcatggca cgatcattca gatgccatca
     7081 gcaaattaca atatacaatg attggtgatc cttctcaagc gattacacgt caatttgatg
     7141 tattagatga aacttctggt cttgcacaac gcggtacttt catcgttgac ccagacggtg
     7201 tggttcaagc agcagaaatc aatgcagacg gtatcggccg tgacgcaagc acacttgtac
     7261 acaaaatcaa agcagcacaa tacgttcgtc aaaatccagg tgaagtttgc ccagcgaaat
     7321 gggaagaagg tagcgaaact ttaactccag gattagactt agtaggtaaa atttaaggag
     7381 gctatactga atgttaaatc aagaattaaa gcaacaactt tcacaacttc ttgatttgat
     7441 ggaaggtgac gttgtactga aagtgagcac tggcgatgac gatcattctc aaaaaatgaa
     7501 cgatctcgtc aatgaagttt cagacatgtc atctcgaatt acagtagaaa aagctgaatt
     7561 aaagcgtacg cctagcttta gtatcaacag accaaatgag gacactggca ttacatttgc
     7621 tggtgtccct cttggtcatg agttcaattc ttttgtcctt gcactcttac aagtaagtgg
     7681 tcgtgcacca aaagaagaac aatctgtaat tgatcaaatc aagtctatta acgaacccct
     7741 tcattttgaa acatttatca gcttaacatg tcaaaaatgt cctgatgttg ttcaagcgtt
     7801 aaacttaatg agtgtcatca atccgaatat tacacatacg atgattgatg gtgcagtgtt
     7861 caaaaaagaa gcagaagaca ttatggcggt ccctgcaatt ttcttaaatg gtgaacaatt
     7921 tggtaacggc cgtatgacag tgacagacat tctgagtgcg ttaggtcaag gtcctgatgc
     7981 ttctgaattt gaaaacaaag aaacatttga tgtcctcgta gttggcggcg gtcctgcaag
     8041 tgcaagttct gccatctatg ctgcgcgtaa aggtttaaaa acaggtatcg tagcagatag
     8101 aattggtggt caagtgaatg acacagctga tattgaaaac ttaattggcg tgaagaagac
     8161 gacaggtcca tcacttgcga caagccttga agcacacatt aaagactaca atgtagatgc
     8221 gatgactggc gtacgtgcag aaggattaga aaaatcagat gatatcgttc atttgacttt
     8281 agataacggc gcagtactta aaacacgctc actcattatc gcaacaggtg cacgttggaa
     8341 gaaaatcggt gtaccaggtg aagacacatt cgcaaacaaa ggtgtcgcat actgcccgca
     8401 ctgtgacgga cctctattcg aaggtaaaga cgtcgctgtt atcggtggcg gtaactctgg
     8461 tgttgaagcc gcgattgact tagcaggtat ttgtaaaagt gtaacagtcc ttgagttcgg
     8521 tgagtcatta aaagcagact ctgtattaca agatcgctta aattcattac cgaatacaac
     8581 agtgattaca caagctgcta cgaaagagat tactggcgac gatcgtgtca acgggctcac
     8641 gtatacagat agagctacag atgaagaaaa acatgttgat ttaaatggtg tcttcgttca
     8701 aatcggtctt tctcctaata cagaatggtt aggtgatact gttcaacgta accgcatggg
     8761 tgaaattgaa gtcgaccgtt taggaaacac gaacattcct ggtgtctttg cggcaggcga
     8821 ctgtacagac caacgctata aacaaattat tatttctatg ggatcaggcg caacagcagc
     8881 attatctgca ttcgactact tgattcgtaa ctaaatagga ttcatatcat taatcggact
     8941 ggtgagaaag ggttgtcttt tcaccagtcc gattttctat ttttattcaa cacagctttt
     9001 tcatccatcg aagtaagcat gtgagagccc tttgagtgca atcactacaa tcgacctagg
     9061 ctgattcagt aaacaaaaga taagatggga cacaaaaatt gagcttatcc ccatcctcaa
     9121 gtgaaaggtt gattgttttg aaatactgta attggcattc cactttttta aaacacgatc
     9181 cccatttgaa gtttagagac aagcgtaaga ttgctagaac ggtgcgtact tataaaatca
     9241 agtccttatt gattgcaaat ttgggcgaga ctcctgaggg atcagctgaa ccggcaaatc
     9301 cactaacgct tccaccaatg taacagttca atcaagcgtt agttagttaa aggttcagcc
     9361 cctaggaaag ggagcccctt gagtgcaatc aaaaaaggac aaacacctta aaatagtaaa
     9421 gcatggttct gcaattggga atcaacatta tcctacaaaa acgaaatcaa ccagttccaa
     9481 attttagtaa aaatgctgac aatggcatcc cacagttttt gcaagaaatt acgtgtttcc
     9541 tcattatcta aatccttcaa cttcttcagt ttgtcgccgg cttggctttg aatcatttct
     9601 tttaattcag tcgcctgttt tttaaacgca tccggatctt ggttgactac attggattgc
     9661 gcgacgttca tcatgatatt ttgaataacc gcaatttcgt tatcacttaa aatctgatac
     9721 agtccacgct ctgttaacgt ttggttgacg atttggttga ttgttgtact gttcagctgt
     9781 tgatgcgacg cttttgcttc agcgatttgg gctttcattt ctgcaactgc tgcattcaac
     9841 gcttcatcag aatagccatc tttattttga tgattttcac taatttgcgc taaatgattc
     9901 atttcttggt tcgcattttg aatatcttgc gcatttaaac gatgaccttg tgtagcataa
     9961 gctttataaa tacctgtcaa tgcaccttca ccagtcacct gatcgacaga agcaatttta
    10021 atcgttgcat cttgaatacc tgatgtaatc gctgcattca tatactgttc tcgtgtaata
    10081 cgtgtaatat tttcaggcgt ttcaatttct acgtccacac cactcgtaaa gcgttttggt
    10141 ttaatcaaag cactagaatg gataaagtcg tattctgtcc cggtatattc aatgacatcc
    10201 gtattggtta ctttatacgt cgtcacattg ttgccgaccc ctaacttttc tttcgtctca
    10261 gcaagttggt tgttattcaa atcggcgcct t
//
