LOCUS       NZ_LR134263            11041 bp    DNA     circular CON 05-APR-2024
DEFINITION  Staphylococcus delphini strain NCTC12225 chromosome 1, complete
            sequence.
ACCESSION   NZ_LR134263
VERSION     NZ_LR134263.1
KEYWORDS    RefSeq.
SOURCE      Staphylococcus delphini
  ORGANISM  Staphylococcus delphini
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus; Staphylococcus intermedius group.
REFERENCE   1  (bases 1 to 2798161)
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (18-DEC-2018) WTSI, Pathogen Informatics, Wellcome Trust
            Sanger Institute, CB10 1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900636325.1-RS_2024_04_05
            Annotation Date                   :: 04/05/2024 03:36:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,651
            CDSs (total)                      :: 2,569
            Genes (coding)                    :: 2,507
            CDSs (with protein)               :: 2,507
            Genes (RNA)                       :: 82
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 62
            CDSs (without protein)            :: 62
            Pseudo Genes (ambiguous residues) :: 0 of 62
            Pseudo Genes (frameshifted)       :: 22 of 62
            Pseudo Genes (incomplete)         :: 40 of 62
            Pseudo Genes (internal stop)      :: 16 of 62
            Pseudo Genes (multiple problems)  :: 13 of 62
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:43:04
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 975221
            Orig. end                         :: 986262
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LR134263.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11041
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="4"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11041
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11041
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6041](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6041
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(64..78)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 22.18"
                     /tool="antismash"
     gene            183..1115
                     /locus_tag="EL101_RS04400"
                     /old_locus_tag="NCTC12225_00913"
     CDS             183..1115
                     /EC_number="2.7.1.107"
                     /GO_function="GO:0003951 - NAD+ kinase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019166450.1"
                     /locus_tag="EL101_RS04400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12225_00913"
                     /product="diacylglycerol kinase"
                     /protein_id="WP_019166450.1"
                     /transl_table=11
                     /translation="MRKRARIIYNPTSGKEVFKRALPDVLIKMEQAGYETSAYATQKVG
                     DATEEAARAIEAQYDLLIVAGGDGTLNEVVNGIAEKPNRPKLGLIPMGTVNDFGRALHL
                     PTDIFEAVDVILDGKTVQVDIGKMNSRYFINLAGGGKITEVSYEAPSKLKSIVGPFAYY
                     IKGFEMLPQMHAVDVRIEFDSQVFEGEIMLFLLGLTNSMAGFEKLVPDAKLDDGMFTLL
                     IVEKANIAELGHIMTLASRGEHIKHPKVHYHKAQSVNISSFSDMPLNVDGEYGGQLPAN
                     FLNLVRHIEVFSPAQEDNALLIDAPTQSE"
     gene            1488..1709
                     /locus_tag="EL101_RS04405"
                     /old_locus_tag="NCTC12225_00914"
     CDS             1488..1709
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002487177.1"
                     /locus_tag="EL101_RS04405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12225_00914"
                     /product="hypothetical protein"
                     /protein_id="WP_096597651.1"
                     /transl_table=11
                     /translation="MKVLTTILDFLAFVCVSLLFLKFVVHTVNGIFDWHLRWYFLEDIP
                     HMAIILLVLMFVFAIPSEMIKEKEKREK"
     gene            1905..2120
                     /locus_tag="EL101_RS13480"
     CDS             1905..2120
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019469869.1"
                     /locus_tag="EL101_RS13480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_096597653.1"
                     /transl_table=11
                     /translation="MIKILDTLIFICVIVLGSKYVIQSANTIFDLNLRWYFLEDVPYLS
                     LILTILIFVLYILSEYLKEKSSKAKE"
     gene            2548..3912
                     /gene="rlmD"
                     /locus_tag="EL101_RS04415"
                     /old_locus_tag="NCTC12225_00915"
     CDS             2548..3912
                     /EC_number="2.1.1.190"
                     /GO_function="GO:0008649 - rRNA methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="rlmD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014613462.1"
                     /locus_tag="EL101_RS04415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12225_00915"
                     /product="23S rRNA (uracil(1939)-C(5))-methyltransferase
                     RlmD"
                     /protein_id="WP_096597655.1"
                     /transl_table=11
                     /translation="MSLVKKNEIYEGKVVDLTHEGHGVIKRDRYPIFIPQTLIDEEVQY
                     KVIKVKKNFSIGKLMNVKKASPDRVTPPCEYYQQCGGCQLQHLSYPAQLEMKRKQVMNL
                     FHHKGKMAEVPIHDTIGMDDPWHYRNKSQIPVGTNRHGQLQMGFYRQRSHDIIDMDHCL
                     IQNDDQNAMMNVIKSLLEKYHIPAYNEQKHQGLVRHVVIRKGYYTNEVMVIFVLNGKKL
                     PHQNDIVTALTTQFPQIVSIKLNFQTNKTNVIMGHTSKTIYGKDIIEDTLDDLTFEIGD
                     LSFYQINVTQTQKLYRQALQYAKLTGNEVVLDAYCGIGTISLFMAPHAQHVYGVEVVPE
                     AIEDAKRNARNNQLNNTTFVAGAAEDVILKWQQEGIQPDVVTVDPPRKGCDATFIETLN
                     ALAPKRIVYVSCNPSTQLRDIEMLKAAYTLKEITPVDMFPHTTHVETVALLERKY"
     misc_feature    4113..4127
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     strong, score: 26.38"
                     /tool="antismash"
     gene            4199..4948
                     /locus_tag="EL101_RS04420"
                     /old_locus_tag="NCTC12225_00916"
     CDS             4199..4948
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EL101_RS04420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NCTC12225_00916"
                     /product="hypothetical protein"
                     /protein_id="WP_096597657.1"
                     /transl_table=11
                     /translation="MGGINCGHSNNRVVKNDMYRLEYASYTKYLFKCFEDFCNANAWVE
                     EFTLLEIDDNDKALIAYKKALLAFQEAITNLQSARNSLSNSYNEIAPLFKYSQLKNGSV
                     NQYKKFDHSFAKGVFEKGGVVTNETKVWESVIISLQNGGEVDYLNYQQSKLVIFENTLQ
                     NLFEEYQKLEKYIRQGVSHVAIRDIEVDITPLTAMALTKISELMSSLTYLCLVEYSAHT
                     SVSGKTIDVLDLLPKTNKNSIQHLKAN"
     gene            5001..6041
                     /locus_tag="EL101_RS04425"
                     /old_locus_tag="NCTC12225_00917"
     CDS             5001..6041
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF014661.4"
                     /locus_tag="EL101_RS04425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12225_00917"
                     /product="YcaO-like family protein"
                     /protein_id="WP_096597659.1"
                     /sec_met_domain="YcaO (E-value: 1.7e-23, bitscore: 81.1,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLENVSEHGVSGFYTYHFTEGSSFRPCATSIIEKEAIKATKDEFM
                     ELMLISSKSFPFVFFGGKSLGNFKLPIHLHPFMWQKRTIQDVNWYNQMNVKYVPFYNYK
                     DGSLKYIPKELSVYYEKTKGIGLSFSPQEGYSYARDIELAKLKAAMELIEKDIVTLWWH
                     RETASRIIVIDDIDEDLRIIRNQLLNQGIDITLLDIENDLGVYVVVCILKQDSFPSVTY
                     GSAAHFEIKGAVKHAIFEAISCIVGLRYEFINFKKIRTSFTYPDFISDSPLSNLSDYKE
                     ILNLKTAINKYDIYYSCISVDEGYLVKAYCYELQPTLYSDTVPLTKRFFIVNNKEVRIK
                     DDFPFI"
     gene            6052..7242
                     /locus_tag="EL101_RS04430"
                     /old_locus_tag="NCTC12225_00918"
     CDS             6052..7242
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="EL101_RS04430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12225_00918"
                     /product="MFS transporter"
                     /protein_id="WP_096597661.1"
                     /transl_table=11
                     /translation="MKTKRIIASDFLTTMMSSALTIYIYWFAYQYFSSQIIISIIGFGQ
                     LSGVFLSSLGGGISDSMNKLLFIKVLNFFKVGLLLMVLVLEKVMNMEILLPLFMFGSTV
                     IGGLQSPTLESLVPFLASSDEALFRINSVVSSSTQVASIMAIVLSAVYISFLSFTTIVF
                     VTFLITAIATILLVGLMVETPLQSTSVLNNMKQGASYIFKTPYIRNLIPVALVMNFSFW
                     SIFLLLPKIANDSFSFLKTSYSGMELSFALGGVLGGIIFAKYFYDVKDKYRLFKRTLFT
                     QSYVLLLLGLVLLIPNSALAYTGMLLCWFLYALINTIFSILYFGKIQLKVPRDMIGSVF
                     GAILTLFSLVNPVAAIMSGFLVSLFKIPLLIVLLSSLMLLAAWSIRFLADVETVFD"
     gene            7256..8629
                     /locus_tag="EL101_RS04435"
                     /old_locus_tag="NCTC12225_00919"
     CDS             7256..8629
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="EL101_RS04435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12225_00919"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_164715567.1"
                     /transl_table=11
                     /translation="MSVLALKDIRCEIGGKLLFEADDLTIEEGDVIGLIGKNGAGKTCL
                     LKMLSGQLSDYTGHISGNLLTYFSELCITEDMTQSGGELSISNFLNALRQSVPLYLLDE
                     PTTYLDQQHIKKVVRTIKRSPSSFCIASHDRAFLDAVATKIWLIEQGKITEYHGSFSDY
                     MRERMIQLSQYEHDLKQYQKEKKKIKQSLQMMKEKQNQKKGKPKKMSGSEYRIAGVKTK
                     IGVKQKKLQKGITQQQNRLEQLKQPDRVEDQYDISFLSQLHRLPKRKIIIPSHEAKMGQ
                     KRLWHTPTIHLNSGDKLGIIGRNGVGKTTYLNDLVSVLPSTYKICYFRQNHFQYLDPKM
                     TVFETIVEATNGHLSEHHIRTLLALLDFKRDKAFRLVGDLSQGERVKVSLLSLLVAESD
                     ILILDEMTNFLDIKAIEAVEKVLAAYSGILIFVSHDQYFVEHLATTILDMDTFKKCRL"
     gene            9209..9974
                     /locus_tag="EL101_RS04445"
                     /old_locus_tag="NCTC12225_00921"
                     /pseudo=""
     CDS             9209..9974
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020219999.1"
                     /locus_tag="EL101_RS04445"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12225_00921"
                     /product="group II intron maturase-specific
                     domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MYRKSPSLMELVVRPNNIEKAIKKVKKNKGAPGIDGMKVSELHAH
                     FAQYFPQITKKLLEGTSQPQAVRKVQIPKPNGKMRVLGIPVARDRVIQQAIRQVIEPGI
                     DRTFSNHSHGFRPTAEAKRNLIRTLRKITKRNRPSTFKEIITEINQVTRGWINYFGRGF
                     IRGFIETTQILVKPPT"
     misc_feature    complement(10234..10248)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.48"
                     /tool="antismash"
     misc_feature    complement(10477..10490)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 20.05"
                     /tool="antismash"
ORIGIN
        1 gtgggaggat ataaagaggt gaacgagaca gcttgttgtc gctatagatt atatgtacgc
       61 ttttgaaaac gatgttgacg ttattttctt atcattttta agaatttgct tgtttttagc
      121 tttcattaca tctttgttta ctataatata agttgtgagt actgaaaaat tgagggatat
      181 aaatgagaaa acgtgcgaga ataatctata atcctacatc gggtaaagaa gtgtttaaac
      241 gtgcattacc tgatgtacta atcaaaatgg aacaagctgg ttatgagacg agtgcctatg
      301 cgacccaaaa agttggcgat gcgacagaag aggcggcgcg tgcgatcgag gcccaatacg
      361 atttgttgat tgtcgctggt ggggacggca cattgaacga agtcgtgaat ggtattgctg
      421 aaaaaccgaa tcgtcctaag ttaggcttaa ttcctatggg gacggtgaat gatttcggtc
      481 gagcactcca tcttccaact gatatttttg aggccgtgga tgtcatttta gatggcaaaa
      541 ccgtccaagt cgatatcggt aaaatgaata gccgttattt tattaatttg gctggcggtg
      601 gtaaaattac ggaagtttcg tatgaagcac cgagtaaatt aaaatcaatt gtcggacctt
      661 ttgcttacta tattaaaggg tttgaaatgt tgccacaaat gcatgcggtc gatgtgcgga
      721 ttgaatttga ttcgcaagtc tttgaaggtg aaatcatgtt gttcttactc ggtttaacca
      781 attcaatggc tggttttgag aagttagtac cagatgcgaa attggatgac gggatgttta
      841 cactgctgat tgttgaaaag gcaaatattg cagaattggg gcacattatg acacttgcct
      901 cacgcggtga acatattaaa cacccgaaag tacattatca taaagcgcaa tcggtaaata
      961 tttcatcctt tagtgatatg ccattaaatg tagatggtga atacggtggg cagttaccgg
     1021 ccaacttttt aaatttagtc cgtcatattg aagttttttc acctgcacaa gaagataacg
     1081 cattattgat tgatgcacca acacaatcag agtaaccgag tctaattgcg cacaaaaatt
     1141 aaaaaagatg atgactacaa acgtcacaac aatactctcg tgggggagtg ggactttgaa
     1201 atctaacgtt aatgttaaat ttttggtcct gctccttttt attgaaattg tgaaaaaagt
     1261 taagggatca ttacaaaaat attacactac ttttaaataa gtatggtatc atctttaatg
     1321 agctatatac taacttaaaa aataaagtat ccatcaagtg ttagtttttt gtaagagcgt
     1381 tcgtagggta ctgctatctt tggtaagtcc aatagatttc gctcacagtg gtctaaatta
     1441 atttgttttg actaaaaata gaatttaaaa caagaggtgc tcaactgatg aaagttctaa
     1501 ctactatatt agattttttg gcgtttgtat gtgtaagtct attattttta aagtttgtag
     1561 ttcatactgt caatgggatt tttgattggc atttacgatg gtatttttta gaagatattc
     1621 cacacatggc aattattttg cttgtattaa tgtttgtgtt tgccatacct tcagaaatga
     1681 taaaagaaaa agaaaaaaga gaaaaatagt ttgatcttaa aaatatgtag atactatagg
     1741 cgctttaaaa gaggtcatgt taggttgacc aattattttt atgtattaaa tcgaatttta
     1801 acatcttatc gctatgatta tgcatatttt gtcaaacttt gcttcaaata tatacatact
     1861 tttttcttga ttgttattaa acctgaagaa aggaagaatt ttaattgatc aaaatattag
     1921 atactttaat attcatttgt gtaattgttt taggatcaaa atatgtgatt caatcagcta
     1981 acacgatatt tgatttgaat ttaaggtggt actttttaga agatgtcccc tacctttccc
     2041 ttattttgac aatcttgatt tttgtgttat acatattatc cgaatacctt aaagaaaagt
     2101 catcaaaggc aaaagaatga gatgatacag caactcattt cttaatggtg agcaacattg
     2161 ttttgtaata caatcgttaa tccattgagc tgaaaaaaat ttcttagttt tgatatagtg
     2221 aaaataaacg ttaacttata ttatacttta aacattgatt gataaaggag ttcagtgtaa
     2281 agttataaaa gtgtaatgaa ttttgcgatt gatgaatgat tggaagtgaa gcatcaagcg
     2341 tacgacatgt ggtatcacct ggtattaaca gtggagggga tgttcgcgtt aaggattatt
     2401 gaaaaagcga ataaagctga acttagtcat atgatgataa caggctctcg tgggggagcg
     2461 ggactttgaa atctaacgtt aatgttaaat ttttggtcct gctcctttcc cttgtaagtt
     2521 gaatttgtga aaagtgagat gaataagatg agtttagtga agaaaaatga aatctatgag
     2581 ggaaaagttg tggatttgac acacgaaggt catggtgtga ttaaaagaga tcgttatccc
     2641 atctttatcc ctcagacgtt aatagatgaa gaagtgcaat ataaagtcat taaagtgaaa
     2701 aagaatttct caatcggtaa gctgatgaac gtgaaaaagg cgagcccaga tcgtgtgacg
     2761 ccgccatgtg aatattatca acaatgtggc ggatgtcaac ttcaacattt gtcatatcct
     2821 gcgcaattag agatgaaacg taaacaagtg atgaatttgt ttcatcataa aggaaaaatg
     2881 gcagaagtgc cgattcacga cacgataggg atggatgatc cttggcatta ccgcaacaag
     2941 tctcaaattc cggttgggac gaatcgtcat ggtcagttgc aaatgggctt ttatcgtcag
     3001 cggagtcatg acattattga tatggatcat tgcctgattc aaaatgatga tcaaaacgct
     3061 atgatgaatg tgattaaaag tttactagaa aaatatcaca ttccagctta taacgaacaa
     3121 aaacatcaag gtctcgttcg tcatgttgtg attcgtaaag gctactatac gaatgaagtg
     3181 atggttattt ttgtgctcaa cggtaaaaag ttgccgcatc aaaacgacat tgtgaccgct
     3241 ttaacgacac agtttccgca aattgtgagt atcaagttga atttccaaac gaacaaaacg
     3301 aatgtcatta tggggcatac gtccaaaacc atttacggta aagacattat cgaggatacg
     3361 ttagatgatt tgactttcga aattggcgat ttatcgtttt atcaaatcaa tgtgacacaa
     3421 acacaaaaat tgtatcgtca agcgttacag tatgcgaaat taacgggtaa tgaagtggtg
     3481 ttagatgcgt attgtgggat tgggacgatc agtttattta tggcaccgca tgcacaacat
     3541 gtatatggtg tagaagttgt ccctgaagcg atagaggatg cgaaaaggaa tgcgcgcaac
     3601 aatcaattga acaatacaac atttgtcgct ggtgcggctg aagatgtcat tttaaaatgg
     3661 caacaagagg ggattcagcc agatgtggtg acagtagatc caccacgcaa aggctgtgac
     3721 gcgacattta ttgaaacatt aaatgcgtta gccccaaaac gtattgtcta tgtgtcatgt
     3781 aatccaagta cacaattacg cgatattgaa atgttgaaag cagcttatac acttaaagaa
     3841 atcacacctg tcgatatgtt cccgcatacg acacatgtcg aaacagtagc gttgttagaa
     3901 agaaaatatt gatataggtt aaagcgcaaa gggttctagg gacatttttt ttagaatgtg
     3961 actgagtgcc cttttttgtt ttggtgatat atagagaata gtacgccgga tttgatttga
     4021 taaataagtt tgtcgtcaat agacatttgt aaaattgtaa aaatattgag acacattaga
     4081 cattttgcgt ttattagcat ctttccagaa ttaatattca gaaaattttg aataaaaagt
     4141 ttacttttga acctatatct gttatattta gggtgtaata ttaagagggg gtgccattat
     4201 gggtggtatt aattgcggac attccaataa tagagtagta aagaatgata tgtatcgatt
     4261 agaatatgca tcttacacaa aatatttgtt taaatgtttt gaagattttt gtaatgcaaa
     4321 tgcatgggtt gaagagttta cacttttgga gattgatgat aatgataaag ccctaattgc
     4381 atataaaaaa gcattacttg cctttcagga ggcgattact aatttacaga gtgctagaaa
     4441 ttcacttagc aatagttaca atgagattgc gcctttattt aaatatagtc aattaaaaaa
     4501 tggttcagta aaccaatata aaaagtttga tcattccttt gctaaagggg tattcgaaaa
     4561 gggaggggtt gtgacgaacg agacaaaggt ttgggagtct gttattattt ctctgcaaaa
     4621 tggaggagaa gtagattatt taaattatca acaaagtaag ttggttattt ttgaaaatac
     4681 attgcaaaat ctatttgagg aatatcaaaa attagaaaaa tatatacgac aaggtgtatc
     4741 acatgttgca attagagata ttgaagttga tatcacgccg ttaactgcaa tggccttgac
     4801 taaaatcagt gaattgatga gttctttaac atacttatgt ttagtcgaat attcagcaca
     4861 tacaagtgtt agtggtaaaa cgattgatgt attggattta ctaccaaaaa caaacaaaaa
     4921 tagtatacag catctaaaag caaattgatt tttataaact gtatctatac gatacagttt
     4981 ttttatgtag ggggattaat atgttagaga atgtttctga acatggggtt tcaggatttt
     5041 acacatatca ctttacagag ggaagctcat ttagaccatg tgccacaagt attatagaaa
     5101 aggaagcgat aaaagctact aaagatgagt ttatggagtt aatgcttatt tcaagtaaat
     5161 cttttccatt tgtatttttc ggaggtaaat ccttaggtaa ttttaaacta cctattcatc
     5221 ttcatccgtt tatgtggcaa aaacgaacta tccaagatgt gaattggtat aatcaaatga
     5281 atgttaagta tgtccctttt tataactaca aggacggatc tttgaagtat ataccgaaag
     5341 aattaagtgt ctattatgaa aaaacaaaag ggattgggct atcttttagt cctcaagagg
     5401 ggtattccta tgctcgagat attgaacttg ctaaattaaa agcggctatg gaattaatag
     5461 aaaaggatat tgttactttg tggtggcata gagaaacagc aagtagaatt attgtgattg
     5521 atgatattga tgaggattta agaattatta gaaatcaatt attaaatcaa ggtatagata
     5581 tcacgctatt agatattgaa aatgatttag gtgtttatgt ggttgtgtgt attctcaaac
     5641 aagatagctt tccatcagtc acttatggta gtgcagcaca ttttgaaatt aaaggtgcag
     5701 ttaaacatgc aatttttgaa gcgatttcat gtattgtggg tttgaggtat gagttcatta
     5761 attttaaaaa aatccgtact agttttacgt atcctgattt tattagtgat agtccattga
     5821 gtaatttatc cgattataaa gagatattga acttgaaaac agccattaat aaatatgata
     5881 tatattattc ttgtatttct gttgatgaag gatacttagt caaagcgtat tgttatgaat
     5941 tacaaccgac tctgtatagt gatacggttc ctttaactaa acgattcttc atagtaaaca
     6001 ataaggaagt caggattaaa gatgattttc cgttcatata gaaggtgagt tatgaaaact
     6061 aaaagaatta tcgcgtcaga ttttttaaca acgatgatgt cttcagcctt aaccatttat
     6121 atatactggt ttgcttatca atatttctct agtcaaatta tcatatccat tatcggtttt
     6181 ggacaattaa gtggtgtgtt tctctcaagt cttggtggtg gcatctcaga cagtatgaac
     6241 aagctgttat tcatcaaagt tctgaatttt tttaaagtag gattactttt gatggtgttg
     6301 gtattagaaa aggttatgaa catggaaatt ttgttgccac tgtttatgtt tggttcaaca
     6361 gtgataggag gtttacagtc acctacgtta gaatcattgg ttccattttt agccagcagt
     6421 gatgaggcgc tttttcgtat taactctgtg gtttcgagtt caacacaggt tgcatccatt
     6481 atggcgattg ttttatctgc agtttatatt tcatttctct cttttacaac gattgttttt
     6541 gtgacatttc ttatcactgc catcgcaaca attttacttg taggactgat ggtggaaacg
     6601 ccattgcagt ctacttcagt ccttaataat atgaagcagg gggcgagtta tatctttaaa
     6661 acgccttaca ttcgtaacct tattccagtt gcattggtca tgaatttctc gttttggagt
     6721 atctttttgc tcttacctaa aatcgccaat gacagttttt catttttaaa aacctcttat
     6781 agtggcatgg agctctcctt tgccttagga ggtgtcttag gtggcatcat atttgcgaaa
     6841 tacttctatg atgttaaaga taaatatcgt ttatttaaga ggacattgtt tacacagagt
     6901 tacgtcttgt tgttattagg actcgtttta cttattccta acagtgcgct tgcctataca
     6961 ggaatgctgt tgtgctggtt tttgtatgct ttgatcaaca cgattttctc tattctctat
     7021 tttggaaaga ttcaattgaa agtccctaga gatatgattg gcagtgtttt tggggcaatt
     7081 ttaacgctct tttcattagt caatcccgtg gcagccatca tgtcgggatt tctcgtttcg
     7141 ctttttaaaa tacctctgtt aattgtattg ttgtcttcac tcatgttgtt agctgcctgg
     7201 agtattcgct tcctagcaga tgttgaaacg gtatttgatt aaagggggga gtgatatgtc
     7261 tgtattagca cttaaagata tcaggtgtga gataggtgga aaattattat ttgaggcgga
     7321 tgatttaacg attgaggaag gcgatgtcat tggcctcatc ggaaaaaacg gggctggaaa
     7381 gacgtgtttg ttaaaaatgt tatcaggaca gttaagcgat tatactggcc atatttcggg
     7441 caatcttctg acttatttta gtgaactctg tataacggag gatatgacgc aaagtggtgg
     7501 agaattaagt atttcaaatt ttcttaacgc attaagacag tccgtgcctc tctatttgtt
     7561 ggatgaacct acaacgtatt tagatcaaca gcatattaaa aaagtagtga gaacgattaa
     7621 gcgctcccca tcttcttttt gtatagcgag ccatgatcgg gcttttttag atgcagttgc
     7681 aactaaaatt tggttgatag agcaaggaaa aataacagaa tatcatggtt ctttttcaga
     7741 ttatatgcga gaacgtatga ttcaattatc tcaatatgaa catgacttga aacaatatca
     7801 gaaggaaaag aagaaaataa aacaatcact tcaaatgatg aaagaaaagc aaaatcagaa
     7861 aaagggaaaa cctaagaaga tgagtggctc agaatatcgt attgctggtg tcaaaacgaa
     7921 gatcggtgtg aaacaaaaga aactccagaa ggggattacg caacaacaaa ataggttaga
     7981 acagttaaaa caacctgatc gcgtcgaaga tcaatatgat atttcctttt tatcacaact
     8041 tcatcgttta ccaaaaagaa aaatcatcat tcctagtcac gaagcgaaaa tgggtcaaaa
     8101 aaggttgtgg cataccccaa ctatccattt aaatagtggt gataaattag gaattattgg
     8161 tagaaatggt gtaggcaaaa ccacttattt aaatgacttg gtttccgttt taccgtctac
     8221 atataaaatt tgttattttc gacaaaatca ttttcagtac ttagacccaa agatgacagt
     8281 atttgaaacg attgtcgaag ctacgaatgg tcatttaagc gaacatcata ttagaacttt
     8341 attggcgttg ttagatttta aaagagacaa ggcattccgg ttagtaggag atttaagcca
     8401 aggggaacgt gtgaaagttt cattattgtc gctcttagtt gctgagtctg atattttgat
     8461 tttagatgaa atgaccaact ttttagatat aaaagctatc gaagcagtag aaaaggtgct
     8521 tgctgcatat tcaggcatac tgatatttgt gagtcatgat cagtattttg tggaacattt
     8581 agcgactaca attctagata tggatacctt taagaaatgt agattgtgat agcgttatgt
     8641 aaatttttat agacaatatc atttgatgac aaggcactta tacgttatag gtgtcttttt
     8701 ttggtgcgcc cggcatgggt aacatcttga cggtgaaagt ccgttacagg cttggtagta
     8761 ggaactgtta gcgaaagaca agggtgtcca ttgcgaagtg gaatctgaag gaagtcggac
     8821 gcaaacactc gcactgacga acagaaacat catactaagg ctatgtagaa tggacgaatc
     8881 tgccaaacaa gatgaagtcc aatactaccc gagttctata tagtcaatga tgcggtgaca
     8941 tgagtggaaa gaggttacac cttacccggg gaggtctcat cagcggtact tctatcgtag
     9001 taacaacgaa tgatgagaag tcagcagaag tcatagtagg gaaaatgtac cgaaggactg
     9061 aacaatattc aatacaaagt aaagattgga ggttatagat ttacgacgta cagaatacgg
     9121 tttaaccggc aacttgtgga aggataagta gtggaacgaa aaaagaatac ataagtgtgt
     9181 acagtgaatc ttaggtgaaa tgaaagaaat gtatcgtaag tctccatcat tgatggagct
     9241 cgttgtaaga ccgaacaaca tagaaaaagc tatcaagaag gttaagaaaa acaaaggtgc
     9301 tcctggaatt gacggcatga aagtcagcga actccatgct cactttgcgc agtactttcc
     9361 gcagataacg aaaaaactgc ttgaaggtac atcccaacct caagcagttc gaaaagttca
     9421 aattcccaaa ccaaatggga aaatgcgtgt gcttggtatt cctgtcgcta gagacagagt
     9481 catacaacaa gccattagac aagtgattga accaggcatt gaccgaacat tttcaaacca
     9541 tagccatggt ttcagaccga ctgcggaagc aaaaagaaat ttaatacgca ccttaaggaa
     9601 aataacgaaa cgaaatagac ccagtacctt taaagagatt atcactgaaa ttaaccaagt
     9661 gacgcgaggt tggataaatt actttggtag aggttttatc agaggattta ttgaaaccac
     9721 gcaaatcttg gttaaaccgc cgacttagac aactcattct taaacggtgg aaaagagtta
     9781 gaacgaaata taagatgttg cgtcaatatg gtcttgacca tagaagtgca atgaaaatcg
     9841 cacagtctcg caagaaatac tggcggttat cgaacacgca cgaggttcat cgtgcactta
     9901 caacaaaaca actctacaag tggggattaa tcccattagc ccagcttgca gagttggctt
     9961 acgcaagata ttgaaccgcc gagtacggaa ccgtacgctc ggtggtgtga gaggacgagt
    10021 agtcaattaa tggctattct cctactcgat tatgtaacat tgggattgaa atagcatgac
    10081 agtcatttca gcttgctcac ttttattgtt ttaaacagta tggctttgca tgttaagtgt
    10141 gattacaggg gagtgcaagg caagtcattt tgatatcgtg ccgctttatc acacatttgc
    10201 atttaagttg tattcgaggg taaagaaact gtcaaatttc tgaaaagatc acatctataa
    10261 tgaatatgat aattatccac tcacatatgt tatactaatt gttcaaaatg aatggtctat
    10321 ttaaaataat cgaggagaac aaaaaatgta taaaaagtat gtaaatgcta ttcagctaga
    10381 gggatttgtc aaattaatat gcattccagt attaatcggg ttggtcacgt ttttattacc
    10441 atcactgata agtccgatgg ttggattatt aaagggcaat cctacgtttg agataggttc
    10501 tgtagcgagc attataggta tgttagtggc tgtgattctc atgcctattg tgatgacgaa
    10561 agtgtcgaaa attaagctga ccacactggg gattacaaaa gaaaaggcga ttacgcaaat
    10621 cttgattggg agtgcggtgg ggattctagc actcagtttc gtagcgtgtg tcatcttttt
    10681 gcttggcggg attaaaatcg aatccaacag tttaatgctc accactggat taataggggg
    10741 cttattcttt tttattttac aagggacttg ggaagaattg atttatagaa gttacctcat
    10801 gccacacttt tccaaaaaat acggtgataa gatagcggtg attgcgacca gtgtgatatt
    10861 tacattaggt catgcattaa atcccaatat gcaaatttta ccggtgatga atttatttat
    10921 agctggcgtc gtttttgcac ttgtatatta ttacagcggg aatttgttat tcgtaggtgc
    10981 acttcacggt ttatggaatt tttctcaagg ctatattttc ggtgcagaag tatccggaaa
    11041 c
//
