LOCUS       NZ_LR134263            20705 bp    DNA     circular CON 05-APR-2024
DEFINITION  Staphylococcus delphini strain NCTC12225 chromosome 1, complete
            sequence.
ACCESSION   NZ_LR134263
VERSION     NZ_LR134263.1
KEYWORDS    RefSeq.
SOURCE      Staphylococcus delphini
  ORGANISM  Staphylococcus delphini
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus; Staphylococcus intermedius group.
REFERENCE   1  (bases 1 to 2798161)
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (18-DEC-2018) WTSI, Pathogen Informatics, Wellcome Trust
            Sanger Institute, CB10 1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900636325.1-RS_2024_04_05
            Annotation Date                   :: 04/05/2024 03:36:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,651
            CDSs (total)                      :: 2,569
            Genes (coding)                    :: 2,507
            CDSs (with protein)               :: 2,507
            Genes (RNA)                       :: 82
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 62
            CDSs (without protein)            :: 62
            Pseudo Genes (ambiguous residues) :: 0 of 62
            Pseudo Genes (frameshifted)       :: 22 of 62
            Pseudo Genes (incomplete)         :: 40 of 62
            Pseudo Genes (internal stop)      :: 16 of 62
            Pseudo Genes (multiple problems)  :: 13 of 62
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:43:04
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 545478
            Orig. end                         :: 566183
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LR134263.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20705
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="CDPS"
                     /region_number="1"
                     /rules="CDPS"
                     /tool="antismash"
     cand_cluster    1..20705
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="CDPS"
                     /kind="single"
                     /product="CDPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20705
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="False"
                     /core_location="[10000:10705](+)"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10705
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
     gene            799..1374
                     /gene="narJ"
                     /locus_tag="EL101_RS02290"
                     /old_locus_tag="NCTC12225_00476"
     CDS             799..1374
                     /GO_function="GO:0051082 - unfolded protein binding
                     [Evidence IEA]"
                     /GO_process="GO:0051131 - chaperone-mediated protein
                     complex assembly [Evidence IEA]"
                     /codon_start=1
                     /gene="narJ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019167015.1"
                     /locus_tag="EL101_RS02290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12225_00476"
                     /product="nitrate reductase molybdenum cofactor assembly
                     chaperone"
                     /protein_id="WP_096596227.1"
                     /transl_table=11
                     /translation="MIDLHMLNTYKDTFGYMSQQLSFPEKLTFHPKTFEEVFDETHPAF
                     PHVVAYREAMYEKSLSEIQAFYTDTFDFNEKATLYMTYNQLDTQKERGQMLAKLKVLYE
                     MFGLEMPASELSDYLPLMLEFLYAARFDGDTRAQENVQLVIMIIEDGTYAMMKHLESER
                     NPYAHLIRGLRETFKRCIVQDKEVTQHV"
     gene            1367..2044
                     /gene="narI"
                     /locus_tag="EL101_RS02295"
                     /old_locus_tag="NCTC12225_00477"
     CDS             1367..2044
                     /GO_component="GO:0009325 - nitrate reductase complex
                     [Evidence IEA]"
                     /GO_function="GO:0008940 - nitrate reductase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019645 - anaerobic electron transport
                     chain [Evidence IEA]"
                     /codon_start=1
                     /gene="narI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_501140.1"
                     /locus_tag="EL101_RS02295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12225_00477"
                     /product="respiratory nitrate reductase subunit gamma"
                     /protein_id="WP_096596226.1"
                     /transl_table=11
                     /translation="MFNQFLWVIFPYLCLAVFVIGHIARYRYDQFSWTAKSSEFIEKKQ
                     LKWGSLLFHLGVIPVFFGHVVGLLIPAHWLEAVGVNNHVYHIGAVYIGSIFGIITLIGM
                     FLLTARRITKQNVRRLSSASDIFVNFLLLLIVFVGCYATLVTNATTPEFDYRQTISIWF
                     RGLFTLSPDASLMTEVPLAFQLHVLLGFTIMACWPFTRLVHVWSVPVTYASRSYIIYRK
                     HKI"
     gene            2060..2521
                     /gene="nreA"
                     /locus_tag="EL101_RS02300"
                     /old_locus_tag="NCTC12225_00478"
     CDS             2060..2521
                     /codon_start=1
                     /gene="nreA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014613057.1"
                     /locus_tag="EL101_RS02300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12225_00478"
                     /product="nitrate respiration regulation accessory nitrate
                     sensor NreA"
                     /protein_id="WP_096596225.1"
                     /transl_table=11
                     /translation="MNQIDFSQHDYQDEIDRLRDEYQFDFAGIALPSEDHAGMKIKWRY
                     VSGNLNERYRRIVLRNGHGIAGNVMKTGKPMIIPDTTDDAIQNALFDYPILMSEQLTAL
                     IAIPLWHNHRVKGVLLFGQRDQKPLPHIANDISSIKGVGGLTSEDKVMQ"
     gene            2522..3562
                     /locus_tag="EL101_RS02305"
                     /old_locus_tag="NCTC12225_00479"
     CDS             2522..3562
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019167973.1"
                     /locus_tag="EL101_RS02305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12225_00479"
                     /product="sensor histidine kinase"
                     /protein_id="WP_096596224.1"
                     /transl_table=11
                     /translation="MPQQQTELLNFLQAYYHQTSEMIIFINAQGQVIDMNEAAKRVIST
                     DNDMSGISTTICGHCEGYTNEQALRTCKNCFLQSPEIGDTTFQVFMKTTDNKIEPFTAN
                     YQTIDEERQIKAFTLQNVTAQLQRQEKLYQRNMIQKTIAAQENERKRISRELHDGVVQE
                     LINVNVEMRLLKYQSDMDVILANAKNIEGLMTKLIDDLRNLSSELRPSSLDDLGLDAAF
                     KTYFKQMENNYGLAINYHFDIDSERFDAEIETVVYRIVQEAVFNAMKYAGVDDVDVIIR
                     KDDHYLYAEVSDQGRGFEPSESPKGTGLGLYGMYERAELVNGKLNIETQKGKGTIVSLE
                     VPISQK"
     gene            3575..4225
                     /gene="nreC"
                     /locus_tag="EL101_RS02310"
                     /old_locus_tag="NCTC12225_00480"
     CDS             3575..4225
                     /codon_start=1
                     /gene="nreC"
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002464689.1"
                     /locus_tag="EL101_RS02310"
                     /note="Involved in the regulation of the the nitrate
                     reductase operon narGHJI; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="NCTC12225_00480"
                     /product="nitrate respiration regulation response regulator
                     NreC"
                     /protein_id="WP_019167019.1"
                     /transl_table=11
                     /translation="MRIVIADDHAVVRTGFSMILNFQEDMEVVGTAADGVEAYQKVMEH
                     APDVLIMDLSMPPGESGLIATSKILDSFPNTKILILTMYDDEEYLFHVLRSGASGYILK
                     NAPDEQLLLAIRTVYQGETYIDPKMTTSLVKEFVHSSHDGEYSNDPFKVLSKRELEILP
                     LIAKGYGNKDIAEKLFVSVKTVEAHKTRIMDKLNLKSKPELVEYALKKKLLDF"
     misc_feature    complement(4303..4314)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 19.35"
                     /tool="antismash"
     gene            <4845..5000
                     /locus_tag="EL101_RS02315"
                     /old_locus_tag="NCTC12225_00481"
                     /pseudo=""
     CDS             <4845..5000
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013851913.1"
                     /locus_tag="EL101_RS02315"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12225_00481"
                     /product="transcriptional regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="DDDTNPWILMSDDLSELINTKIYLVENFNTLERYIDGIERMLEVA
                     KGRVVV"
     misc_feature    complement(5021..5035)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 22.75"
                     /tool="antismash"
     gene            5063..5743
                     /locus_tag="EL101_RS02320"
                     /old_locus_tag="NCTC12225_00482"
     CDS             5063..5743
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018154.4"
                     /locus_tag="EL101_RS02320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12225_00482"
                     /product="zeta toxin family protein"
                     /protein_id="WP_240622763.1"
                     /transl_table=11
                     /translation="MTRGKTPIKRPIAILLGGQSGAGKTTIYRIKQSHYNGNIIIIDGD
                     TFRLQHPKFIDIQKEYGKKSVEYTNEFAGRMVESLIELQSEQHYHLLIEGTLRTVDVPR
                     RTAVSLKSKGYQVELSLIATKPYLSYLSTLLRYEQNYSISPKYARATPKKYHDNIVGNL
                     VKNLNILEKEIIFDRIQIFKRDKSCVYDSYKNGELMASEKLHELLYGFWDLKKKKCWNI
                     VKTN"
     gene            complement(5926..6258)
                     /locus_tag="EL101_RS02325"
                     /old_locus_tag="NCTC12225_00483"
     CDS             complement(5926..6258)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EL101_RS02325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NCTC12225_00483"
                     /product="hypothetical protein"
                     /protein_id="WP_096596223.1"
                     /transl_table=11
                     /translation="MINYRSYSDEQQIFMLNIGGLDIYSIRKKVVKVIEKLIKPFSSQH
                     HRYTFIDVDEVTVLIIQAETQFIPTLIRRLCKKGLAIYEVKLVEEQDALFDQFSAHMNK
                     SKAYVL"
     misc_feature    6274..6294
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 25.01"
                     /tool="antismash"
     misc_feature    6459..6474
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.55"
                     /tool="antismash"
     gene            6582..7760
                     /locus_tag="EL101_RS02330"
                     /old_locus_tag="NCTC12225_00484"
     CDS             6582..7760
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014613064.1"
                     /locus_tag="EL101_RS02330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12225_00484"
                     /product="nitrate/nitrite transporter"
                     /protein_id="WP_096596222.1"
                     /transl_table=11
                     /translation="MKQSKGGVQLVLQTLSLVAGFMAWSIIAPLIPFISQDIKISSGQL
                     SIILAIPVILGSVLRVPFGYLTNIVGAKWVFFTSFIVLLVPIFLLSQASSPGALMFAGF
                     FLGVGGAIFSVGVTSLPKYFSKDKVGLANGIYGMGNLGTAVSSFLAPPIAGIIGWQNTV
                     RSYLIVMAVFAIIMFFLGDNKEPKVKVPLVEQTRILMKNYKLYYLSLWYFITFGSFVAF
                     GLFLPNFLVQNFGIDKVDAGIRTGVFIALATCLRPLGGILGDKFNAVTMLKIFFSVMIA
                     GALVLGVSSQISLFTIGCLTVSVCAGIGNGLVFKLVPHYFTKEAGVANGIVSMMGGLGG
                     FFPPLVISVVTAFTGTSHFAFILLAIFGLIALVTMFNLSKREKASEKKAAIL"
     misc_feature    complement(6601..6615)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 21.12"
                     /tool="antismash"
     gene            complement(8210..9388)
                     /locus_tag="EL101_RS02335"
                     /old_locus_tag="NCTC12225_00485"
     CDS             complement(8210..9388)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014613404.1"
                     /locus_tag="EL101_RS02335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12225_00485"
                     /product="MFS transporter"
                     /protein_id="WP_096596221.1"
                     /transl_table=11
                     /translation="MIKPKSNVKLYVLCLLAFFASLIQNIYTPIIPRLHNEFHVSLLYI
                     NLTVGVFIFIIAIMQIILGRSIDTKDSKQLLLTGLSIIIISSFICSITHNFFIFAISRS
                     VQAIGCGIIPLVTLTLLARSSTGNERASAMANYQIFLSSAPALAPILGSILGANWNYFG
                     IFIFIFIIAVLLFIVISFIEIPNIEKGANRTIKPVEPKYLTDHVFITFILFGFLVFFTY
                     FSILVDLPILLTHRYHLNEGWIGFLFLPITISVIMGSIFYKCISKIKDELLILRYTVLA
                     FSVVTLLFGIMNSINIIILAIIIFGSGFLVGIVPAILSTLITQRYENIKGKVLGVFNFI
                     RYIGMTIGAITIGLVTPHNTYLYFLAVSVVIFIVFFYLMTKVFERSFKVETK"
     gene            complement(9369..9848)
                     /locus_tag="EL101_RS02340"
                     /old_locus_tag="NCTC12225_00486"
     CDS             complement(9369..9848)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000367344.1"
                     /locus_tag="EL101_RS02340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12225_00486"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_096543226.1"
                     /transl_table=11
                     /translation="METQKKVILTLQQFIIERENANKRRQNFKDNNEHHLSLTQFHILE
                     LIANNDKANNKFLANKLNISNPAITKSIKKLLSRGLVIEEHNHNNKREIHYKLTEDGAQ
                     LSSVHDKLHQRAVKSYEDVLNVFDENELNVIVKFLERSIQALKKEDADNNDQTEK"
     gene            10001..10705
                     /locus_tag="EL101_RS02345"
                     /old_locus_tag="NCTC12225_00487"
     CDS             10001..10705
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) CDPS:
                     CDPS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011276926.1"
                     /locus_tag="EL101_RS02345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12225_00487"
                     /product="tRNA-dependent cyclodipeptide synthase"
                     /protein_id="WP_096596220.1"
                     /sec_met_domain="CDPS (E-value: 5.2e-58, bitscore: 193.5,
                     seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYDFKVEFLTTNCKKIYQKKKHVILGISPFTSKYNEKYIRKIIQW
                     ANNNFDEFTILLGGEESKNILECLGYSTTKANRKVRKEINRQIRFCEDELIKCGRTVTS
                     RIYRFSDFKQNVSYIGIYENIVNLFNTDNNFKNSCLKMSMQALQSKKNSVNTSVEITKE
                     ALEYAAQYVLAELPFFLNANPIINTQETLMAYHEQWELGEKIATNKFDLKMSKHQGYII
                     LTERGNHYVKRV"
     gene            10689..11885
                     /locus_tag="EL101_RS02350"
                     /old_locus_tag="NCTC12225_00488"
     CDS             10689..11885
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011276927.1"
                     /locus_tag="EL101_RS02350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12225_00488"
                     /product="cytochrome P450, cyclodipeptide
                     synthase-associated"
                     /protein_id="WP_096596219.1"
                     /sec_met_domain="p450 (E-value: 7.1e-33, bitscore: 111.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKESRSIFERDYEVNPVPYFNFFRKYDPVHYEETVNAYFISNYE
                     DVKFILKNDDIFTTKTLAERAEPVMKDRVLAQMSGYEHSSKKKVILKGMTGIYLEKILP
                     MIEKRTNDIIDMYIKKKEIDLVSDFGEKFAVQSSLDLLGIDIKDAEIIRKWHNGIAKFI
                     TSFNLNEQEVKHSLDCSDKLEEYLMPLIKEKKDSKKIDLISILHGYKNGKNRINDTEIL
                     ALTLNVLLAATEPVDKTLAYLFYNLLSNPSQYRDIQANHKLLKLAIKETLRFNSPVQLI
                     PRQLSKPFTLYETKLNTDDVVICMIGAANRDPKAFINPDEFNIYRTLEENKILSSHSLN
                     LSFGYGVHTCVGAAFSLIQLETVVSILIRRLKNIKLETMDLCQEYGHRKKRILPRFAC"
     gene            complement(11936..12796)
                     /locus_tag="EL101_RS02355"
                     /old_locus_tag="NCTC12225_00489"
     CDS             complement(11936..12796)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1026: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF033516.0"
                     /locus_tag="EL101_RS02355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12225_00489"
                     /product="IS3 family transposase"
                     /protein_id="WP_197718003.1"
                     /transl_table=11
                     /translation="MYRFIYEYRHEFRVVKMCQVLSVSKSGYYDWKNRKPSARIVKRDG
                     LKKHIYQIYIKSQKRYGSPKITQILRSHGHTVTQRTVSRLMKELGIRSITKKKYKATTH
                     SKHHLPVYPNLLNQQFKVSQLGSVWVADITYVYTKEGWLYLATVMDLFSRRIIGWAMAA
                     RMTKELVMSALNKAYTIQEPKEGLIHHSDRGSQYASIEYQNLLREKGIQSSMSRKGNCY
                     DNACIESFHSIIKKELIHHQNYKTRNEAMFSIVEYILTFYNSKRVHSTLNDMSPIEFEK
                     KYATK"
     gene            complement(12796..13083)
                     /locus_tag="EL101_RS13335"
                     /old_locus_tag="NCTC12225_00490"
     CDS             complement(12796..13083)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1164: transposase
                     IS3/IS911 family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF013677.4"
                     /locus_tag="EL101_RS13335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12225_00490"
                     /product="transposase"
                     /protein_id="WP_197718001.1"
                     /transl_table=11
                     /translation="MARRKYDYSFKMEAIQLVESGRRASEVSRDLDIPIQTLTRWLSIY
                     RKDGEKGFVGSGKRTSNKQAEADLEKRLRDLEEENKILKKAMHIFAKDQK"
     gene            complement(13453..14028)
                     /locus_tag="EL101_RS02360"
                     /pseudo=""
     CDS             complement(13453..14028)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013828.4"
                     /locus_tag="EL101_RS02360"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="ATP-binding protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSQYLPNIKHLSDFDFTFQPSINKQEVLTLKSMHFLEKRINICFL
                     DNSGVGKTHLAM"
     gene            <14255..15148
                     /locus_tag="EL101_RS02370"
                     /old_locus_tag="NCTC12225_00491"
                     /pseudo=""
     CDS             <14255..15148
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001798866.1"
                     /locus_tag="EL101_RS02370"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12225_00491"
                     /product="reverse transcriptase domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="YEEGYKIAVDCDLKQCFDMLNHDKLMYLFEHHVQDKSISKFIRRS
                     LQVAAIDLSGEVAERKIGAPQGGVISPLLCNIYLHELDKELEKRGHRFVRYADDFVIFV
                     RTKRAGERVMTSVTKFIEKQLKLVVNEEKSRVGAVTRLKFLSCLIIKVNGVYRFRPTTE
                     AKRNLIRTLRKITKRNRPGTFKEIITEINQVMRGWINYFGRGFIRGFIETTPSWLNRRL
                     RQLILKRWKRVKTKYKMLRQYGLDHNSAMRIAQSRKKYWRLSNTHEVHRALTTKQLYKW
                     GLIPLAQLAELAYARY"
     gene            complement(15287..16912)
                     /locus_tag="EL101_RS02375"
                     /old_locus_tag="NCTC12225_00492"
     CDS             complement(15287..16912)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1247: acetylornithine deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019168186.1"
                     /locus_tag="EL101_RS02375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12225_00492"
                     /product="M20 family metallopeptidase"
                     /protein_id="WP_096598693.1"
                     /transl_table=11
                     /translation="MKTQWQTATERALLLKQLVAHQSVTHSEGEQSFPYLVKDQLMSLD
                     YFKARPEQIHLVPTDDGRHAVVALYQGATSHKAITCISHFDTVGVEDYGLYQSEAFDMD
                     ALTATFQAHVEDFDHEVQADILSGQYLFGRGSMDMKPGLMLHMSLIEKAIIEQWDINLI
                     LITVPDEEVTSKGMHAAVAYLDELCQQHQFDIVLHLNSEPTFQQQGNDIHYFYSGSIGK
                     IMPGVFVHGRETHVGTPALGLSSNFVMSYILQEIEYSTRFKETFEGEVTPFPVTLKMND
                     MKHHYDVQTPFRTVALFNLFLFKQNANDVFQQFNAAVKEGMNKAWEAYQQRMKDEDVAP
                     MPQLQLMTYQELYQYACQHHGKRAVQHMLDQAIQNEQEPHAQSIMIIDALIRLCKSLGP
                     VVITFFAPPYYPATNASFHPLVEAIKQTITDTAKQQCNRVSKRIHYFNGISDLSYVAPS
                     PNGSGFDAFRDHTPVFGQTYQIPFEAIERIQAPFLNCGPMGKDAHKVTERVHQQSAFEE
                     LPILLETIIQTHFLNNTNYVDGIS"
     misc_feature    16976..16992
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.37"
                     /tool="antismash"
     gene            17096..17452
                     /locus_tag="EL101_RS02380"
                     /old_locus_tag="NCTC12225_00493"
     CDS             17096..17452
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014613066.1"
                     /locus_tag="EL101_RS02380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12225_00493"
                     /product="DUF3139 domain-containing protein"
                     /protein_id="WP_096543203.1"
                     /transl_table=11
                     /translation="MLKKIIGIILSLIIIFIVVAGAFFAFKGYQKSQNLKMIDQYLTEN
                     HLKDKVIEEKDEYDPRKGIFYKELTIKGDEKNTYIAQPIHMKRGFFLQGFNTETKKHDK
                     KAKYSFFDEDYKLK"
     gene            complement(18030..18977)
                     /locus_tag="EL101_RS02385"
                     /old_locus_tag="NCTC12225_00494"
     CDS             complement(18030..18977)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014613067.1"
                     /locus_tag="EL101_RS02385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12225_00494"
                     /product="lactate dehydrogenase"
                     /protein_id="WP_096598737.1"
                     /transl_table=11
                     /translation="MVNKVALIGLGRVGSQILTDIQYAGLFQEIILIDTDLDRVEGEAL
                     DHVHFQGLSGTHHTRIKVGTYEMLADVDLIIISASIPSNADMADRTKLTAHNTKIIQEI
                     MAQITAVTTSPHIMMISNPVDTMTYIAETQFNYPHHKIMGTGTMLESTRFRTLIADHYH
                     VDPKSVEAFVIGEHGKTTVPVWSRVRIAGMALDEYEQLSGATPISKQGIRDQIDKVSFD
                     VMRKKGWTNSAISRVAVDLAEALFYDENRILPISTVHQNVYNYTNVAFSLPTRVNRDGH
                     HEIFPIQLDESEKAALDQSVAYIQQAIATAESVK"
     gene            19158..20231
                     /locus_tag="EL101_RS02390"
                     /old_locus_tag="NCTC12225_00495"
     CDS             19158..20231
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M42"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014613068.1"
                     /locus_tag="EL101_RS02390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12225_00495"
                     /product="M42 family metallopeptidase"
                     /protein_id="WP_096598739.1"
                     /sec_met_domain="Peptidase_M42 (E-value: 1e-105, bitscore:
                     350.2, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDTKALLQQLTDLNGIAGHEYNVKKVMNDLLEPNSDEMIYDNLG
                     GVFGKKHSKSGQRTIMIAGHLDEIGFMITKIDDNGFIRFTQVGSWWNQVMLSQKVTITT
                     DEGRQIRGIIGSKPPHVLTPEERKRPVEMKNMFIDVGAKDKAEVEAAGIEIGNMITPYS
                     EFETLLNEDYMTAKAFDNRFGCAVAVDVMDELKDEDINVNLVAGANVQEEVGLRGAKVA
                     AHKVKPDLAIAVDVGVAYDTPGLESNGETKVGNGPIVLNLDATNIGHVGLIRHVKKVAQ
                     ANGIDLQWDSIPGGGTDAGSFHTALDGIPSIALSLPLRYMHSNVSILSRKDYQAVVKLV
                     TEIIRALNDEVVDEIIW"
ORIGIN
        1 ttgaagcagg gattccgaca gtgtgttcag aaacatgtac aggccgtatg cgttatttag
       61 gtgtgttact ttatgatgca gatcgcgtgc aagaagcggc atcagctgaa aacgaacaag
      121 acttgtacga aaagcaactc gacttgtttt taaatccatt tgatgaagca gtcattgaac
      181 aagcagaaaa agacggcatt tctcaagaat ggatcgaagc agcacaaaat tcaccgattt
      241 ataaattagc aattgagtat aaattggcat tcccattaca tccagaatat cgtacgatgc
      301 caatggtatg gtactgtcca ccattaagtc cgattatgaa ctactttgaa ggacaaaatg
      361 cgggtaacaa cccagatgcg atattccctg caattgaaga gatgcgcttg cccattcaat
      421 atttagcaga actttttaca gctggagata cagtggcagt gaaaggctca cttcaacgga
      481 tggcaatgat gagaagttac atgcgtgcac aaaatacagg ccgagaattt gatatgtctc
      541 gcctagcacg tgtaggttta acggaacgac aagcgaaaga tatgtatcgc ttacttgcca
      601 tcgcaaaaca tgaagatcgt tttgtcattc cgacatcgca taaagagcaa tacatggata
      661 cgtacacagc acaaggtagt caaggttacg gtggtgaaca tttcggtgcg aactgtgacg
      721 gttgcggcgt gccagtgggt acaggtggaa aaacaggtca agaaatgtat aatgagcgtt
      781 tctatggagg gattttccgt gattgatcta cacatgttga atacgtataa agatacattc
      841 ggttatatga gtcagcagtt gagctttcct gaaaaattga ctttccaccc taaaacattt
      901 gaagaagtgt ttgatgagac acatccggct ttcccgcatg tcgtggcgta tcgagaagcg
      961 atgtatgaaa agagtttgtc agaaatacaa gctttttaca cagacacgtt tgattttaat
     1021 gaaaaagcca ctttgtatat gacttacaat caactggata cacaaaaaga acgcggtcaa
     1081 atgttggcga agttaaaagt cctctatgaa atgtttgggc ttgaaatgcc agcgtcagag
     1141 ttgtcggatt acttgccact catgttggaa tttttatatg cagcacgctt tgatggtgat
     1201 acacgtgcgc aagaaaatgt acaactcgtg atcatgatta ttgaagatgg aacgtacgcg
     1261 atgatgaaac atttggaaag tgagcgcaat ccatatgctc atttaattcg tggtcttcgt
     1321 gaaacgttca agcgttgtat cgtacaagat aaagaggtga cacagcatgt ttaatcagtt
     1381 tttatgggtg atatttccgt acctctgtct tgcagttttt gttattgggc acatcgcacg
     1441 ttatcgttat gaccaatttt catggactgc aaaatcgagt gaatttattg agaagaagca
     1501 attaaagtgg ggcagtttgt tgtttcatct tggcgttatt cctgtgtttt tcggacatgt
     1561 cgttgggtta cttatccctg cacattggtt agaagcggtc ggtgtgaata accacgtcta
     1621 tcatatcggt gcagtgtata ttgggagtat ttttggtata ataacattaa ttggcatgtt
     1681 tttgttaact gcgcgtcgga ttacgaaaca aaatgttcgt cgtttaagtt cggcgtcaga
     1741 tattttcgtt aactttttat tattacttat cgtatttgtc ggctgttatg ccacattagt
     1801 gacgaatgcg acaacgccag agtttgatta ccgtcaaacg atttctattt ggtttagagg
     1861 gttgtttaca ttaagtccag atgccagttt gatgacagag gtgccacttg catttcaatt
     1921 acacgtcctt ttaggattta cgattatggc ttgctggccg tttacgcgtc ttgttcacgt
     1981 gtggagtgtg ccggtgacgt atgcaagtcg tagttatatt atttatcgca aacataaaat
     2041 ttaatggaag gtgatgaccg tgaaccagat tgatttttcg caacatgatt atcaagatga
     2101 aatagataga ttgcgtgatg aataccagtt tgattttgct ggtattgctt tgccatcaga
     2161 agatcatgca ggaatgaaaa tcaaatggcg ttacgtgtca ggcaacttga atgaacgata
     2221 tcgtcgcatc gtgttacgta atgggcatgg cattgcaggg aatgtgatga aaacaggcaa
     2281 gccgatgatc attcccgata ctacagatga tgcaattcaa aatgcattgt ttgattatcc
     2341 tatattaatg agtgagcaat tgacggcttt gatcgcgatt ccactatggc acaaccatcg
     2401 tgtgaaaggc gtcctattat tcgggcaacg tgaccaaaaa ccattacctc acatcgcaaa
     2461 tgatatctcg tccattaaag gtgttggcgg tttgacaagt gaagataagg tgatgcaata
     2521 aatgccacaa caacagactg agttattaaa ttttttacaa gcctactatc atcaaacatc
     2581 tgaaatgatt atttttatca atgcacaagg ccaagtgatt gatatgaatg aagcggccaa
     2641 gcgagtcatt tcaaccgata atgatatgag tggtatttca acaacgatat gtggccattg
     2701 cgaagggtat acgaatgaac aagcattacg tacttgtaaa aattgttttc ttcagtctcc
     2761 agaaattggt gatacgacat ttcaagtgtt tatgaaaaca acggataata aaattgaacc
     2821 tttcacagca aactatcaaa cgattgatga agaacgacaa atcaaggctt ttacattaca
     2881 aaatgtgacc gcacaattgc agcgacaaga aaaattgtat caacgcaata tgattcaaaa
     2941 gacaatcgct gcacaagaaa acgagcgtaa acgtatttca cgtgaattgc atgatggggt
     3001 tgttcaagaa ttaatcaacg tgaatgtaga gatgcgttta ttgaaatatc aaagtgatat
     3061 ggatgtcatt ttagcgaacg ccaaaaatat tgaagggtta atgacaaagc tgattgatga
     3121 tttgcgtaat ctatcatcag aattgcgtcc atcttcatta gatgatttag gattagatgc
     3181 agcatttaaa acgtatttca agcagatgga aaataactat ggtttagcga ttaattatca
     3241 ttttgatatt gattcggagc gctttgatgc ggaaatcgaa accgtcgttt accgtatcgt
     3301 gcaagaagcg gtatttaatg cgatgaagta tgcgggcgtc gatgatgtgg atgtcattat
     3361 tcgcaaagac gatcattacc tttatgcaga agtttcagat caagggagag gatttgaacc
     3421 gagtgaatcg cctaaaggaa caggtttggg gctttatggc atgtatgaac gtgctgaatt
     3481 ggtgaatggc aagctcaata ttgaaacgca aaaaggaaaa ggcacgattg tgtcactcga
     3541 agtaccaatc agccaaaagt gaggggaatg tagcatgaga atcgtgatag cagatgatca
     3601 cgctgttgta cgtacgggtt tttcgatgat tttaaacttt caagaagata tggaagtggt
     3661 gggtaccgct gcagatggtg tcgaagcata tcaaaaagtg atggagcacg caccggacgt
     3721 attgattatg gatttaagta tgccaccagg agaatcaggt ttaattgcga cgagtaaaat
     3781 tttagatagt ttcccaaata caaaaattct catactcacg atgtatgatg atgaagaata
     3841 tttatttcac gtattgcgaa gtggcgcgag tggctatatt ttaaaaaatg cgccggacga
     3901 acaattattg ttagcgattc gtacagttta ccaaggtgag acgtatattg atccgaaaat
     3961 gacgacttct ttggtgaaag agtttgtgca ttcatctcat gatggagagt attcgaatga
     4021 tccgtttaaa gttttgtcga agcgggagtt ggagatttta ccgttaattg cgaaaggtta
     4081 tgggaataag gatattgctg agaagttgtt tgtatcggtg aagacggttg aggcgcataa
     4141 aacgcgtatt atggataagt tgaatttgaa gtcgaagccg gagttagtgg agtatgcgtt
     4201 gaagaagaag ttgttggatt tttagtgttt tcatagcatg gttgtgttaa aagttgggga
     4261 agagtgaggt tgttgtacac gccttactac aaaggcgatg gtgaaaacat tttctgttac
     4321 aaacgtatat tgcatgattg ctaccttggg ctcgcgttcc taggggctga gggggaggtt
     4381 gtgacaaaag cgcttaggat ttgagcagaa cagagcgatg agcaaaattg atttccaaat
     4441 tttgccgaaa tcgcgggagt tctgtcgaaa atcctgcttt tggaacaccg tttattgatt
     4501 cccagcgcac ccattcattg tggattttgg gagcagtaca gaaatctcat gtgtaacaaa
     4561 gatttcgtcg tactgccccc gcaaggctga cttgacttct caaaagtgta tacgttgaga
     4621 agtcaaacag ctactgcgat aaacggtagc cacttttaaa gttaagaagt cactgttagc
     4681 agtatgcaga caattccctc aggagtctcg cccaggtgtg caaatgatat ttataaacat
     4741 ttcgagttga ggatgttaca cgatattttg tggcatcctc aacttttaat ttgaatcggg
     4801 ttgttgatac actttcatcc attttttctc atactactac tactgacgat gatacaaatc
     4861 cttggatatt aatgagcgat gatttatcag aactcatcaa tacaaaaatc tatcttgttg
     4921 aaaattttaa tacattagag cggtatatag atggaataga gcgcatgtta gaagtggcaa
     4981 aaggacgagt tgtagtctaa atgggattaa tagaatacac agaaattgat tttcaaacgg
     5041 cacttgaacg taattgtagg gattgactag aggaaaaaca ccaataaaaa gacccattgc
     5101 aattttattg ggcggccaga gtggggcagg aaaaactaca atttatcgta ttaagcaatc
     5161 gcattataat ggtaatatca ttattattga cggggatact tttcgattgc aacacccaaa
     5221 attcattgat atacaaaagg aatatggtaa aaaaagcgtt gaatatacaa atgaatttgc
     5281 aggacgaatg gttgaatcac tcattgagtt acaaagcgaa caacattatc atctgctcat
     5341 tgagggaact ttaagaactg tcgatgtacc gagacgaaca gcagtatctt taaaatccaa
     5401 gggttatcaa gttgaattat cacttatagc aacaaagcct tatttatcat acttgagtac
     5461 tttattaaga tacgaacaaa attatagtat ctcccccaaa tatgcacgtg ctacgcctaa
     5521 aaaatatcat gataatatag tagggaattt ggtgaaaaac ttaaacattt tagaaaaaga
     5581 aataattttt gacagaatac aaatatttaa gcgagataaa agttgtgtat atgattctta
     5641 taaaaatggt gaattaatgg cttcagaaaa attacatgag ttactatatg gtttttggga
     5701 tttgaaaaaa aagaaatgtt ggaatattgt gaaaacgaat tgaaaatatt aagagaagca
     5761 aagagaaaat agtttatata atgcatagct tgttgttcat gtagaatagc aattatttat
     5821 taatgaacga ttatagaatt agaaattaat ttctgtcaca gtctatctga accacaattg
     5881 ctcctcagca aatgctaaga aaaaagctta tgccattcta aatattcaga ggacataggc
     5941 tttagattta ttcatatgag cggaaaactg atcaaataac gcatcttgtt cttctactaa
     6001 ttttacttca tatatcgcta atcctttttt acataaacgt ctaatgagag tagggatgaa
     6061 ttgtgtttct gcttgaatga ttaatactgt aacttcgtcg acatcgataa aagtgtaacg
     6121 atgatgttga gatgagaaag gtttaatcaa tttttcaatt accttaacca cttttttacg
     6181 aattgaatat atgtctaatc caccaatgtt gagcataaat atttgttgtt catcagaata
     6241 cgatcgatag tttatcattt ctaaacacct catttttagt tgtttcgact attataaaat
     6301 aaaaagttta aaaaaccaat gaatctccat tattcaattc acgatccagc attccagttt
     6361 ctgagcttga tcaatggtgc attaatcaaa tttgtaagcg gacactatca ctttcgattg
     6421 ttaggggata cgccatgcaa gaatagggga attccttgtg ttataaattt cacaataccg
     6481 ttaaactgaa cttgaaatcg aatgaggcat ctgctgtgag cgtactgaca atgttcaaga
     6541 tgatgcatca aactcatcaa gtaaagaaag gtgaatgaga aatgaaacaa tcaaaaggtg
     6601 gcgtacaact tgtgctccaa acactcagcc ttgttgcagg gtttatggcg tggagtatca
     6661 ttgccccatt aattccgttt atttcacaag atattaaaat ttcaagcggt caactctcta
     6721 ttattttggc cattcccgtt attctaggat cagtgcttcg tgtgccattt ggctacttaa
     6781 cgaacattgt tggcgcgaaa tgggtgtttt ttacaagctt tattgtgttg ctcgtaccga
     6841 tatttttact cagtcaagcg agctctcctg gcgcgttaat gtttgctggc tttttccttg
     6901 gtgtaggggg cgccattttc tcagtcggcg taacatcatt accgaaatat ttttccaaag
     6961 ataaagtcgg tctcgcaaac ggtatttatg gtatggggaa cttggggact gctgtatcgt
     7021 catttttagc gccaccgatt gcaggtatta ttggatggca aaatactgta cgtagctatt
     7081 taattgtgat ggcagtgttt gcgattatca tgttcttttt aggggacaac aaagaaccta
     7141 aagtgaaagt accacttgtc gaacaaacac gtattttaat gaaaaactat aaactgtact
     7201 acttaagttt atggtacttt attacattcg gctcatttgt cgcatttggt ctgtttttac
     7261 cgaacttcct cgtacaaaat ttcggtattg ataaagtcga tgccgggatt cgtacaggtg
     7321 tgtttatcgc attagcaacg tgtttaagac ctttaggcgg tattttagga gacaagttca
     7381 acgcagtgac gatgctgaaa attttcttct cagtgatgat tgcaggggca ttagttttag
     7441 gggtttcaag tcaaatttca ttatttacaa ttggctgttt aacagtgagt gtttgtgccg
     7501 gtattggtaa tggactggtg tttaagttag tgccacatta tttcacaaaa gaagcgggtg
     7561 tagcaaacgg tattgtttca atgatgggtg gtcttggcgg attcttccca ccacttgtca
     7621 tttcagtggt gactgcattt acaggcacaa gccatttcgc ttttatcttg ttagcgatat
     7681 ttggtttaat cgcacttgtg acgatgttta acttatctaa acgtgaaaaa gcatcagaaa
     7741 agaaagcggc tattttataa tgtgaagaat ctatgcttat ttgaatgata tataacttga
     7801 taaaggaaag ctggctagac ttctcaaaaa tattagttaa gaattgggaa gccagccagc
     7861 tattatacaa tgaagtgtac ttagatttaa ctgaaacgac agtgtgacct ttcttacccc
     7921 tccctctgct tcctcaaaat aatttattgt tagttaattg ttttttagta aataaatatt
     7981 tattttaagt taataagttg tattattaaa aaaattagaa tgcagcttct ttttagtagt
     8041 taagagtaat agtattatta atcgttaagg cttataatca ttaatttaat atacgtatat
     8101 ttaataggta aacgtgatta gtaattaata taaaaaataa ataatgatat ttagcaaatg
     8161 tagattatcg tcactgttaa gctcaaatta atttttatac tagtacttgt tatttagttt
     8221 ctactttgaa tgatcgttcg aatacttttg tcataaggta aaaaaatacg atgaatatga
     8281 ctactgatac agctaaaaaa taaaggtatg tgttatgtgg tgtcactagt ccaatcgtta
     8341 ttgcgccaat agtcataccg atatatctta taaaattaaa tacgcctaat acttttcctt
     8401 ttatattttc atacctttga gttattaaag ttgaaagtat tgccggaacg atgcctacaa
     8461 ggaatcctga cccgaatata atgattgcta gaatgattat gtttatgcta ttcattatac
     8521 cgaataataa tgtgactacg gaaaaagcca acacagtata tctcagtatt agtaattcat
     8581 cttttatctt agaaatacat ttataaaaaa tacttcccat aatgacactg attgtaatcg
     8641 gtaaaaataa gaaacctatc catccttcat taagatgata tctatgcgtt aataggatcg
     8701 gaaggtcgac taatattgaa aaatacgtaa agaagactaa gaaaccaaat aggatgaaag
     8761 ttataaaaac gtgatcagtt aaatatttcg gttccacagg ttttattgtt ctattagccc
     8821 ctttttcaat atttggaatt tcaataaaag aaataacaat gaataataaa acagcaatga
     8881 tgaatataaa aatgaaaata ccaaagtaat tccaattagc gcctaagata ctgcctaata
     8941 taggtgccaa tgctggggcg cttgataaaa atatttgata atttgccatt gccgaagccc
     9001 gctcatttcc tgtacttgac ctagctaata aagttaatgt aacaagggga ataattccac
     9061 aaccgatcgc ttgtactgac cttgatatag caaatataaa aaaattatga gtaatagaac
     9121 aaataaaact ggatataatt ataatgctta gtcctgttaa aagaagctgt tttgagtctt
     9181 tagtatcgat actccgtcct aatataattt gcattatagc aataatgaaa ataaatacgc
     9241 ctacagtcag atttatgtat aataatgaga cgtgaaattc attgtgaagt ctcgggataa
     9301 ttggggtgta tatattttga attagggagg cgaaaaacgc taatagacac aggacataca
     9361 atttgacgtt acttttcggt ttgatcatta ttatcagcat cctctttttt gagcgcttga
     9421 atacttcgct ctaaaaattt aacaatgaca tttagttcat tttcatcaaa aacattcagt
     9481 acgtcttcat aacttttaac tgctctctga tgtaatttat catgtacaga tgaaagttga
     9541 gcaccatcct cagttagttt atagtgaatt tcccgcttat tattatgatt gtgttcttca
     9601 atcactaatc ctctagataa aagtttttta atagatttag taattgccgg attagaaata
     9661 tttagtttgt tggctagaaa cttattgtta gctttgtcgt tattagctat caactccagt
     9721 atatgaaatt gtgtcagaga taaatgatgc tcgttgttgt ctttaaaatt ttgtcttctt
     9781 ttattagcgt tttccctttc tattatgaat tgttgtaatg ttagtattac ttttttttgt
     9841 gtttccatca ttaccactcc ttttggttaa ccggttaatt gtattatgaa gattttttcc
     9901 tctgttgtca aatagaattg ctttaatggg aattatttgg tattatttca ataattaacc
     9961 tagaaacatt ttactggtta attataagga gtgattacta ttgtatgatt tcaaagtaga
    10021 gtttttaacc acaaactgta aaaaaattta ccaaaagaaa aagcatgtca ttttaggtat
    10081 tagtccattt acgagtaaat ataatgaaaa atatattaga aaaataattc aatgggctaa
    10141 taataacttt gatgaattta ctattctgtt aggcggggaa gagtcaaaaa atatactaga
    10201 atgccttggt tattcgacta ctaaagcaaa tagaaaagtg cgcaaagaaa tcaatagaca
    10261 aataagattt tgtgaagatg aacttattaa atgtggaagg actgtcacta gtagaatcta
    10321 taggttttca gattttaagc aaaatgtttc ttatattggg atatatgaaa atattgtaaa
    10381 tctgtttaat acagataata actttaaaaa tagttgttta aagatgtcaa tgcaagcgtt
    10441 gcagagtaaa aagaacagtg ttaatacttc tgtggaaatt actaaagaag cattagaata
    10501 tgctgcccaa tatgtattag ctgaattacc tttcttttta aatgctaatc caattattaa
    10561 tactcaggaa acattaatgg cttatcacga acaatgggag ttaggtgaaa aaatagcaac
    10621 taacaagttt gatttaaaga tgagtaaaca tcagggctat attatattaa ctgaaagagg
    10681 gaatcattat gttaaaagag tctagaagta ttttcgaaag agattatgaa gtgaatcctg
    10741 ttccatattt taattttttt agaaaatatg atcctgttca ctatgaagaa actgttaatg
    10801 cttattttat aagtaattac gaagatgtaa aatttatcct taaaaacgat gatattttta
    10861 caactaaaac tttagctgaa agagctgaac ctgttatgaa agatagagtg ttagcacaaa
    10921 tgtcaggtta tgaacatagc tcgaaaaaga aagttatatt aaaaggtatg acaggaattt
    10981 accttgaaaa aatattacct atgatagaaa aaagaaccaa tgatataatc gatatgtata
    11041 ttaaaaagaa agaaattgat ttagtaagtg attttggtga aaaatttgca gttcaaagtt
    11101 cgttagattt attaggcatt gatataaaag atgcagaaat aattagaaaa tggcataatg
    11161 gtattgcaaa atttatcaca tctttcaatt taaacgaaca agaagttaaa cattctttag
    11221 actgtagtga taaactagaa gagtatttga tgcctttaat aaaagaaaag aaagattcta
    11281 aaaaaattga tctaatttca attttacatg gctataaaaa tggaaaaaat agaataaatg
    11341 atacagaaat tttagcttta acgctaaatg ttttattagc tgcaacagaa ccggttgata
    11401 aaacactagc ttatttattt tataatttgt taagtaaccc cagtcaatat cgagatatac
    11461 aagctaatca taaattatta aaactagcaa ttaaagaaac tcttcgtttc aattctcctg
    11521 ttcaattaat acctagacaa ttatcaaagc cattcacatt atatgagaca aagctcaaca
    11581 ctgatgacgt agttatatgc atgattggtg ccgcaaatag agatccaaaa gcttttatta
    11641 accctgatga atttaatatt tacagaacgt tagaagaaaa taagatacta tcttctcatt
    11701 cactaaactt atcttttgga tatggagttc atacatgtgt aggtgcagct ttctcattga
    11761 tacaattaga aacagtagtc agtattttaa tacgaagact aaaaaatatt aaattagaaa
    11821 ctatggatct atgtcaagaa tacggacaca gaaaaaagag aattctaccg cgcttcgctt
    11881 gctagcctag cccatcatgt acttttaaaa atcaaaaagt acattctgag ttaggttatt
    11941 ttgttgcgta tttcttctca aattcaatgg ggctcatatc atttaacgtt gaatgcactc
    12001 ttttggaatt gtaaaaagta aggatatact ccacaatgct aaacatcgct tcattcctgg
    12061 ttttatagtt ctgatgatgt atcaattcct ttttgatgat actatgaaaa gattctatac
    12121 atgcgttgtc gtaacagttt cctttacgac tcatgctact ctgaatccct ttttcacgta
    12181 gtaaattttg atattctatt gaggcatatt gacttcctcg atctgagtga tggattaatc
    12241 cctctttagg ttcttgaatt gtatacgctt tgtttaaagc tgacatcaca agttcttttg
    12301 tcatacgagc tgccatcgcc cagccaatga ttctacgaga aaacaagtcc atgactgtag
    12361 ctaaatagag ccatccttct tttgtgtata catacgtgat gtcagccacc caaacactgc
    12421 caagttgtga tactttaaac tgttgattca ataaattagg gtagacagga agatgatgct
    12481 ttgaatgggt cgttgccttg tatttctttt ttgtgataga ccttataccg agctccttca
    12541 tcaatctact gacagttctt tgggttacag tatggccatg actcctcagt atttgtgtga
    12601 ttttggggct tccgtatcgc ttttgactct taatataaat ttgataaata tgcttcttca
    12661 aaccatcacg ttttactata cgcgcacttg gcttgcgatt tttccaatca taataaccac
    12721 ttttcgaaac actaaggact tggcacatct tcacaacacg aaattcatgt cggtattcat
    12781 aaataaacct gtatattact tctggtcttt ggcaaagatg tgcatagcct tttttaagat
    12841 tttattctct tcttctaaat ctcttaatcg cttttctaaa tctgcttctg cttgtttatt
    12901 tgacgtacgt ttaccgctac cgacaaaccc tttttcaccg tctttacggt atatactcag
    12961 ccatcttgtt aacgtttgaa taggaatatc tagatctcta gaaacttctg aggcacgtct
    13021 ccctgattcg actaattgaa ttgcttccat tttaaagcta taatcgtatt ttcttctcgc
    13081 catcactgac actcctataa attgatttct tttattatac atgaaattcc tatcaattta
    13141 ccgtgtccgt ttcttagtct agcatcacta ctattcttga ggaagaaggt atttatacta
    13201 gaggacctaa atcaatggtg attagctttg actagtcatt atatttgctt tgtattcaaa
    13261 atttttatat aaataaataa tattgattat atttatttaa aaatatttgt aatggagaat
    13321 gattgctttc aggtgaagat aatttacttt aactatttaa caaagaagca ggaaggttga
    13381 gtggcctaag tctctcatta ttggtgcgct ctacaatgtc aaagcggttt gaaaatgtcg
    13441 ttttttagcg gtttaagagt gacgtatgtt taaacttttt tcgcttttat aatttttaag
    13501 tcggtatgaa tcatctgtaa ttttaaatat ttttgaatga taaatgagtc tatcaatcat
    13561 ggctgctgac gctatcttgt tactaaatgc ccccctagaa aaggggatat tcgtcgttat
    13621 gattgtggat ttcatttcat atcttagtga cattaattga tagaagagat ctgcctgttc
    13681 tttggagatg ggggtatagc ctatctcatc aatgataagt agttcgattc tgtttaattg
    13741 ttttaaagtt ttatttatta ttcctttggc ctctaaagta gttaagattt caattaattc
    13801 tttaaaagta tagaatatcg ttttgatatt ttgtttacaa gcttctgctc ctagctacat
    13861 tgccagatgt gtcttaccga caccactatt atctaagaag catatattga tacgcttctc
    13921 tagaaaatgc atggatttta atgtgagtac ctcttgttta ttaatacttg gttgaaacgt
    13981 gaaatcaaag tcacttaaat gtttaatatt agggaggtac tgggaaatag accttcattt
    14041 cctataagaa agagctgtca aaattctttt ttcagaattt gacggctttt ttcttggtgt
    14101 ggccggcatg ggtaacatct tgacggtgaa agtccgttac aggcttggta gtaggaactg
    14161 ttagcgaaag acaagggtgt ccattgcgaa gtggaatctg aaggaagtcg gacgcaaaca
    14221 ctcgcaccga cgaatagaaa catcatacta aggctacgaa gaaggttata aaatagccgt
    14281 agattgtgac ttgaaacaat gctttgatat gttgaatcat gataagctca tgtatttgtt
    14341 cgaacaccat gttcaagaca agtcaatttc caaatttatc cgtagaagct tacaagtggc
    14401 tgccattgac ctatctggcg aagtcgcaga aagaaagata ggtgcaccac aagggggcgt
    14461 tatctctccc ttactatgta atatttatct acatgaactg gataaagaac tcgaaaagcg
    14521 tggacaccgt tttgtacgat atgcagatga ctttgtcatc tttgtacgca caaaacgtgc
    14581 aggtgaacgc gtcatgacga gtgtaacgaa atttattgaa aagcaactaa agttggttgt
    14641 caatgaagag aaaagtagag taggagcagt cacacgttta aagttcttga gttgtctaat
    14701 aatcaaggtc aatggggttt atcgtttcag accgactacg gaagcaaaaa gaaatttaat
    14761 acgcacctta aggaaaataa cgaaacgaaa tagacccggt acctttaaag agattatcac
    14821 tgaaattaat caagtgatgc gaggttggat aaattatttt ggtagaggtt ttatcagagg
    14881 atttattgaa accacgccat cttggttaaa ccgccgactt agacaactca ttcttaaacg
    14941 gtggaaaaga gtaaaaacta aatataaaat gttacgccaa tatggtcttg accataatag
    15001 tgcaatgaga atcgcacagt cacgtaagaa atactggcga ttatcgaaca cgcacgaggt
    15061 tcatcgtgca cttacaacaa aacaactcta caagtgggga ttaataccat tagcccagct
    15121 tgcagagttg gcttacgcaa gatattgaac cgccgagtac gaactattcg ctcggtggtg
    15181 tgagaggacg aatagtcaaa taatggcatt ctcctactcg attatataaa ctttagtttc
    15241 cattatttta aagggggtgt ctccgtattc aaagttgtat actcatttaa gagataccat
    15301 ctacatagtt tgtgttattc aaaaagtgtg tttgaataat cgtttctaag aggataggta
    15361 attcttcaaa ggcactctgt tgatgcacgc gttctgtcac tttatgagca tctttcccca
    15421 tagggccgca atttaagaag ggggcttgaa tccgctcaat cgcttcaaat ggaatctggt
    15481 acgtctggcc aaatacaggg gtgtgatcgc gaaatgcatc gaatcctgaa ccatttggag
    15541 acggagcaac gtaacttaaa tcactaatac cattaaaata atgaatacgt ttcgatacac
    15601 gattgcattg ttgtttggca gtgtctgtaa tcgtttgttt gattgcttca actaaaggat
    15661 gaaacgatgc attcgttgct ggataatacg gtggtgcaaa gaaagtaata acgacagggc
    15721 caagtgattt acaaaggcga atgagcgcat caataatcat aatagactgt gcatgcggct
    15781 cttgttcgtt ttgaatggct tgatctagca tatgctgaac cgcacgctta ccatgatgtt
    15841 gacacgcata ttgatataac tcttgataag tcatcaactg caattgaggc attggtgcaa
    15901 catcttcatc tttcattcgc tgttgataag cctcccaagc tttgttcatt ccttccttga
    15961 ccgccgcatt aaattgttgg aaaacatcat ttgcgttctg tttgaataaa aaaagattaa
    16021 acaaagcgac tgtacgaaat ggtgtttgga catcgtagtg gtgcttcata tcattcattt
    16081 ttaatgtgac aggaaaaggc gtcacttcac cttcaaatgt ttctttaaaa cgagtactat
    16141 attcaatttc ttgaaggata taactcatga caaaattcga acttaaaccg agtgcaggtg
    16201 taccaacgtg tgtttcgcgc ccatgaacaa aaacgcctgg cataatttta ccaatcgaac
    16261 cactataaaa ataatggatg tcattgcctt gttgttgaaa tgtcggctca ctatttaaat
    16321 gtaagacgat gtcgaactga tgttgctgac agagttcatc taagtaagcc actgcggcgt
    16381 gcattccttt tgaagtgact tcttcgtcag gcacagtgat caaaatgagg ttgatatccc
    16441 actgttcgat gatggctttt tcaatgagtg acatatgtaa catgagaccc ggtttcatat
    16501 ccatactgcc gcgtccaaat aaatattgac cggacagaat atccgcttgg acttcatgat
    16561 caaaatcctc aacatgtgct tgaaaagttg ctgtgagggc atccatatca aaagcttcag
    16621 attggtacaa accataatct tcaacgccca cagtatcgaa atgactgata catgtgatgg
    16681 ctttgtgaga tgttgcccct tgatataaag cgactaccgc atgtcgacca tcatctgtcg
    16741 gtacgagatg gatctgctct ggccgtgctt tgaaataatc gagagacatc aattggtctt
    16801 tcactaaata aggaaacgat tgttcacctt cagaatgcgt cacactttga tgtgcaacga
    16861 gttgctttaa cagtaatgct ctttctgttg ctgtttgcca ttgtgttttc atgctatctt
    16921 ctcctttgtg taacgcttct agcatacaat ctcattgtaa gcgtttttgt atcatttgcc
    16981 aatgacatcc aatgacttta tgacgtttat gtgacggcga aagttctctt agatgtctca
    17041 aactaatttg tgttaagata gtaaaataag atagtacaaa gtgggggcat atgacatgtt
    17101 aaaaaaaata atcggtatta ttttgtcact catcattatt tttatcgttg ttgccggtgc
    17161 attttttgcg tttaaagggt accagaaaag ccaaaattta aagatgattg atcaatattt
    17221 aactgaaaac catttgaaag ataaagtcat tgaggaaaaa gatgagtacg acccgagaaa
    17281 agggattttt tataaagagt taacaatcaa aggcgatgaa aaaaatacat acatcgcaca
    17341 gccgattcat atgaaacgtg gatttttctt acaaggcttt aatacagaaa caaaaaaaca
    17401 tgataaaaaa gcgaaatata gtttctttga tgaagattat aagttgaagt aattgttctt
    17461 tttaagtggg cataccagct ttaaagtttt acgattgcga acatgttctc gcttgatgat
    17521 gtgtataaga tgatgaaagg ggatgagaca taaaaatttt tgatgctatt gatgcaatat
    17581 ttcgattaac ttgtcctccc tatgatttgt ggctttagat tgccttcatg gcttcgcgtt
    17641 cctaggggct ggcccttcaa ctaactaacg cttgattaaa ctgttacatt tctagaggcg
    17701 ttagtggatt ttccggacca gcttgatccc tcaggagtct cagccttctg ggcaatctta
    17761 catcaaatac agtcgattag ggcaagtttc tgaaatcaag aaaacaatag catcaatttt
    17821 tatcccattc acgctcattt tctgaccgtt ttaaagtcat taatgaatat gcaatctatg
    17881 tatggcttga agcttaattt tttcaagccc catcccttgg tatacacaac aaaatatagt
    17941 aaaggagctg aggaatctta atgccccagc tcctttttat gcaacggcaa aaaatggcgc
    18001 tgtgccttat attaagtgcg atgctcatgc tacttcacag attctgctgt tgcgattgct
    18061 tgttgaatgt aggccactga ttgatcgagt gctgcttttt ctgactcatc taattgaatc
    18121 gggaatattt catggtggcc atcgcgattc acacgtgtcg gcaagctaaa agccacattc
    18181 gtataattat atacattttg atggacagtt gaaatcggta aaatgcgatt ttcatcataa
    18241 aagagcgctt ctgctaaatc gacagcaacg cgtgaaatag ctgaattcgt ccaacctttt
    18301 ttacgcatca catcaaaaga aactttatcg atttgatcgc gaatcccttg tttcgaaatg
    18361 ggtgtcgccc cgctcagttg ttcatattcg tctaacgcca tgccggcaat acggacacga
    18421 ctccatacag gcacagtcgt cttaccgtgt tcaccaatca caaacgcctc gacacttttt
    18481 ggatcaacgt gataatgatc ggcaatcaat gtgcgaaaac gtgttgactc taacatggtg
    18541 cctgttccca tgattttgtg atgtggatag ttgaactgtg tttcagcaat ataagtcatc
    18601 gtatctactg gatttgaaat catcatgata tgtggcgatg tcgtcacggc agtaatttgt
    18661 gccattatct cttgaatgat tttcgtattg tgtgctgtga gtttcgtacg atccgccata
    18721 tctgcattag aaggaatgct ggcagaaata atgattaaat caacatctgc taacatctcg
    18781 tatgtaccga ctttaatacg tgtatgatgt gttccgctta acccttgaaa atgcacatga
    18841 tcgagcgctt caccttctac acggtcaaga tctgtatcga ttaaaataat ttcttgaaac
    18901 agacctgcat actgaatatc tgttaaaatc tgactgccta cgcgtcctaa accgatgagt
    18961 gcgactttat tgaccatttg aaatccccct tgaagttgta tcaaagcatg tcattggatt
    19021 gactaaaatt tagataatac tagtataaac tttgtgcaag acaagatgca atgaccaatc
    19081 aattcatcag caagtacatg attcagaatt tttggtatga taagtaggac acatcttata
    19141 aagggggaca atgaataatg aaagatacaa aagcattact ccaacaatta acagacctta
    19201 acgggattgc tggacatgaa tacaacgtta aaaaggtaat gaacgacctt ttagaaccga
    19261 atagcgacga aatgatttat gacaatttag ggggtgtttt cggtaaaaag cactcgaaat
    19321 cagggcaacg taccattatg attgccggtc atctggatga gattggcttt atgattacga
    19381 aaatagatga caacggcttt attcgtttta cacaagtcgg aagttggtgg aatcaagtca
    19441 tgttatcgca aaaggtaacg attacgacag atgaaggccg tcaaattcgc ggcattatcg
    19501 gttcgaagcc acctcatgtc ctcacgcctg aagaacgtaa gcgcccagtt gagatgaaaa
    19561 acatgtttat cgatgtcggc gcaaaagata aagccgaagt tgaagcggca ggcattgaaa
    19621 ttggcaatat gattacgcca tattctgaat ttgagacgtt attaaatgag gattacatga
    19681 ccgcgaaagc atttgataac cgctttggct gtgccgttgc tgtcgacgtg atggacgagc
    19741 ttaaagatga ggacatcaac gtgaatttag tggcgggtgc gaatgtacaa gaagaggtag
    19801 gcttacgtgg cgcgaaagtg gctgcacata aagtaaaacc tgatttagcc attgcggtag
    19861 acgtcggtgt tgcttatgat acaccaggat tagaaagtaa tggagaaacg aaagtaggga
    19921 atggaccgat cgtattaaat ttagatgcga caaacattgg tcatgtcggt ttaattcgcc
    19981 acgtgaaaaa ggtagctcaa gccaatggta tcgacttgca atgggattcc attccaggtg
    20041 gcggtacaga tgccggaagt ttccatacag cattagacgg tattccttct atcgcattgt
    20101 cactgccatt acgttacatg cattcaaatg tatcaattct gagtcgcaaa gattatcaag
    20161 ctgtcgttaa attagtcact gaaattattc gtgcattaaa tgatgaagta gtcgacgaaa
    20221 tcatttggta aaatttaaaa tgacgattca agcagaatac cacttgttca actgagcagt
    20281 ggcgttctgc tttttatgtg gaacgaaaaa atgaattaaa ggaacaaaaa gatattgtct
    20341 tcacatggga gtcatgatag attaaacaaa actataaaga cagcagagga ggctttccat
    20401 gacacatcaa catcaaaaaa ggtggttagg ttatttatta gtcatcattg gcgcttcatt
    20461 ttggggtgta ggtggaacag tctcgcaatg gcttttccaa catgcaaatg tcgatgtcac
    20521 atggtttgta gccgtgcgac tcatgctctc ggggctgtta ttactcggta ttgcttttat
    20581 ttcagaaggt ccgaaagtct ttcacatttg gcgcgataaa cgatccacag cacaaatttt
    20641 aatttacggc ttactcggca tgctgaccgt acaatatact tttatggtta cgatcagcta
    20701 tggga
//
