LOCUS       NZ_LR027842            21083 bp    DNA     linear   CON 04-MAY-2024
DEFINITION  [Pseudopropionibacterium] massiliense strain Marseille-P6184, whole
            genome shotgun sequence.
ACCESSION   NZ_LR027842
VERSION     NZ_LR027842.1
KEYWORDS    WGS; RefSeq.
SOURCE      [Pseudopropionibacterium] massiliense
  ORGANISM  [Pseudopropionibacterium] massiliense
            Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
            Propionibacteriaceae; Arachnia.
REFERENCE   1
  CONSRTM   IHU Genomes
  TITLE     Direct Submission
  JOURNAL   Submitted (25-OCT-2018) URMITE, IHU - Mediterranee Infection, 19-21
            Boulevard Jean Moulin, 13005 Marseille, France
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900607225.1-RS_2024_05_04
            Annotation Date                   :: 05/04/2024 02:04:38
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,146
            CDSs (total)                      :: 3,092
            Genes (coding)                    :: 3,052
            CDSs (with protein)               :: 3,052
            Genes (RNA)                       :: 54
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 48
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 40
            CDSs (without protein)            :: 40
            Pseudo Genes (ambiguous residues) :: 0 of 40
            Pseudo Genes (frameshifted)       :: 11 of 40
            Pseudo Genes (incomplete)         :: 35 of 40
            Pseudo Genes (internal stop)      :: 4 of 40
            Pseudo Genes (multiple problems)  :: 7 of 40
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 15:23:35
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 968148
            Orig. end                         :: 989231
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LR027842.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21083
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="6"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21083
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21083
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11083](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11083)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            2034..2663
                     /locus_tag="E0E39_RS04190"
     CDS             2034..2663
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="E0E39_RS04190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_130873622.1"
                     /transl_table=11
                     /translation="MTVLRSLRSRMLLARVAVQLPLTEAEDRLPGLVMAGIDMAVLTTG
                     GPAEHEANLRILRNLERHLGQRVLLAVDTPEIDADVRVCLPGERDRSRPHRWALLGQVV
                     QERGQIAEPDEAFQFLAVPGMPPGSPLLRAAVEAQPPLKRESVPWFAAGGLDVGSVQVL
                     ADSGVRRVWLTEGGTVAALERIDEILRRAWGGDPAYEDYLGFAVGV"
     misc_feature    complement(2699..2717)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 24.84"
                     /tool="antismash"
     gene            2738..3745
                     /gene="fepB"
                     /locus_tag="E0E39_RS04195"
     CDS             2738..3745
                     /EC_number="7.2.2.-"
                     /codon_start=1
                     /gene="fepB"
                     /gene_functions="transport (smcogs) SMCOG1033: iron
                     compound ABC transporter, periplasmic"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014847060.1"
                     /locus_tag="E0E39_RS04195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Fe2+-enterobactin ABC transporter
                     substrate-binding protein"
                     /protein_id="WP_130873623.1"
                     /transl_table=11
                     /translation="MTNPLFNPISRRAFSGLFPALLALGLTGCGSGATSGGGNASSPAS
                     ARTITHDLGETVVNGTPKRIVSTSVVLTGTLLALDAPVVGSGASKPGAEGFDDVGFFSH
                     WSAIAKERGVKAVYANSKLDIEAVTAEKPDLIIIASTGGDSTKDDYDSLSRIAPTVAIN
                     YNSESWQTVTRQVADVTGTQARAEELTNTFNSRLTELKAAMGGVPTEAVQAIVYTPSNG
                     LSFAKPGGPHDEIFSALGFKLAEAPASSGEEGANRKDFVFATVEQSVQALTSDTLLLVS
                     GDDKTVEQLKADSNYNTTRTVSSGRLVPLGISSFKLDYYSALAMAETLAAAYPR"
     gene            3742..4734
                     /locus_tag="E0E39_RS04200"
     CDS             3742..4734
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006826 - iron ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1011: transport
                     system permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013219.4"
                     /locus_tag="E0E39_RS04200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="iron ABC transporter permease"
                     /protein_id="WP_130873624.1"
                     /transl_table=11
                     /translation="MSRAAWVLLGLAILLPCLVLASFLFGSGDVPAGQVLAVLSGGGTG
                     EQRLIVLGMRGSRTLIALVAGAALGIAGVLVQALTRNPLAEPGLLGVNAGAACAVAIGL
                     GLVRSLPIAMMMLVSLAGALLSGLVVTGASGAWRGRHDPIRIVLVGAAWSAVVSAITTF
                     MLLSDPRIYAEFRFWDAGAVTPRPLDLVIAAAGTLGVGLLAALLLARSMDALALGEEFA
                     RGLGLAAGRARMLVALTCLVLCAAATALVGPVSFLGLIAPFAARLVVGPRHRALIWFST
                     LLGGVTLLAADVLGRVVNPPAEVQAALMCALLGAPLFIGLARARRLVQL"
     gene            4731..5762
                     /locus_tag="E0E39_RS04205"
     CDS             4731..5762
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1011: transport
                     system permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013219.4"
                     /locus_tag="E0E39_RS04205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="iron chelate uptake ABC transporter family
                     permease subunit"
                     /protein_id="WP_130873625.1"
                     /transl_table=11
                     /translation="MSLQVRSVRLGPVSFHARPRTWLVAALAWGIALAGAIAVLFSGSV
                     NMTPEQFWAALVGVGERADVLLLWEFRMPRALTGLVVGACLGTAGCLFQALSRNALGSP
                     EIIGLTGGAALGAVASVMVFRSFGWGTAAGAIIGCLGAALLTWVLSPRGFGGGNRLILI
                     GLGVASLIQPVTVLLLTRADSDSATSARLWLTGTLNARNWSHAVVGAVLFAVILPFALL
                     ISRHLDAAAPGEDFAAGLGVSRRFTQWTATGVGVALTAAAVAVAGPIAFIALAGPHVAR
                     RLLKGPTAPAGVAAGTGAALLVAADLVGANLPGGLQLPVGVTAGLLGGAYLLLLLNGQE
                     RKR"
     gene            5759..6547
                     /locus_tag="E0E39_RS04210"
     CDS             5759..6547
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014847057.1"
                     /locus_tag="E0E39_RS04210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_130873626.1"
                     /transl_table=11
                     /translation="MTGTAQEFPLAASSVRLGYDRKIVIEDITLEVPEGELTMLIGPNG
                     CGKSTLLKALARVLAPKAGYVYLGGTDIHQLRTTAVARRLGFLPQRQSVPPGIKVLDMV
                     SRGRFAHQRFWSRWSQADEEAVASALEVTGLTDLQRADVDELSGGQVQRVWLATVLAQD
                     TPLLLLDEPTTFLDIAHQYEVLKLVRGLRDAGRTVVVVVHDLNQATRFATNLVVMKDGA
                     IVASGLPAEVLTAELVENVFGLPVLVVPDPVTGAPMVVPR"
     gene            6544..7656
                     /locus_tag="E0E39_RS04215"
     CDS             6544..7656
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0008849 - enterochelin esterase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006826 - iron ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1098: enterobactin/ferric enterobactin esterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012958.4"
                     /locus_tag="E0E39_RS04215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="enterochelin esterase domain-containing protein"
                     /protein_id="WP_130873627.1"
                     /transl_table=11
                     /translation="MTTHLLPTPLSATGAPHPATPELPDRLDRSPIVGRRCVIDGVEMV
                     EVTFVAHESPAREVLVHVNSLTDAIRTRLGPAIMAPVGNTGAQILSWWLPADGCYSYRY
                     WRSDEVPRDIGATRAGWMRVHREGQPDPLNPETLPAFDLREQSVWRGPDFEPVPWAPTG
                     EAERQWRLHDDGRFAVLPGDDRTLVLFDGLRWRLAGVASALRAAGLGHTVVAVDTGEGE
                     QRAAWLTTARGCAPLVERARELAGAGREVIAAGQSFGGLACVELAVHRPDLVTAVIAQS
                     ASLWFAGDPVPEPDAEGILLRGLVAGTRALGTPVVVQAGTDERGLIHGARRLAGIAERT
                     GRLAAAEEFRGGHDLSWWRHGLLSGLSVLV"
     gene            complement(7642..10011)
                     /locus_tag="E0E39_RS04220"
     CDS             complement(7642..10011)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005215 - transporter activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1037: heavy metal
                     translocating P-type ATPase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014847055.1"
                     /locus_tag="E0E39_RS04220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAD-IC family P-type ATPase"
                     /protein_id="WP_130873628.1"
                     /transl_table=11
                     /translation="MTGELRGLTADQVAERVREGRVNTLPERSGRTTWQIVRDNVFTRV
                     NAMLAVLFVIVAATMQFAQGAFAILIVANSIIGMVQELRAKRTLDNLAVIGEAHPVVLR
                     DGQRISLPRDQVVADDLIALSPGDQVVVDGEVVAADYLEVDESMLTGEADPVAKSVGDE
                     LMSGAFVVSGSGVYRATKVGAEAYAAQLTAQAAKFTLVNSELRAGIDRILKFVTWLLIP
                     AGLLTIWVQFRQPGTTWQESALRMVGALVPMIPEGLVLLTSMAFALGVIRLGRRKCLVQ
                     ELPAIEGLARVSVVCADKTGTLTQNAMTLGEVIPLAGDADEITGVLAQLVAADPAPNAS
                     MTAIAEATPAASTPWEVTARAPFTSAKKWSGVSFGTRGDWVLGAPDVLAPADVAARAEE
                     IGSTGRRVLLLGRASEPVDSPGAPGMVTPVALLVLDQLVRPDAADTLAYFNEQHVAVKV
                     ISGDNAASVGAVTRSLGVSVAEAVDARTLPAEGEEFTEKIAGADVFGRVTPQQKRAMVA
                     ALQSRGHTVAMTGDGVNDVLALKDADLGVAMGSGSPATRAVAQIVLLDDRFATLPHVVA
                     EGRRVIGNIERVAKLFLSKTVYAVFLALVIGLMGLPNPFIPLQMTVVGWFTIGIPAFLL
                     SLPPNKERARPGFVRRVLSLAVPSGVIIGTVSTITYVVTRGFGAVSPVVQAQASTATLA
                     ALIITSVWVLAVVARPWVWWRLGLVVVSYVFYIAMFLIPWAWLRGQLLLDLDNPSTILF
                     GVVAGLIGAGLVEVVWWLTAKHRGEPARIWRGSDED"
     gene            complement(10001..11083)
                     /locus_tag="E0E39_RS04225"
     CDS             complement(10001..11083)
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015069981.1"
                     /locus_tag="E0E39_RS04225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_130873629.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 2.6e-49, bitscore:
                     165.4, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTSPAHDPTSPAFVSAVGRALIEFLDGQSELASLTDTLPLLEAA
                     RVYAAGGKRLRPAFCYWGYVVAAGRPTDPGPLLRAAASLDLLHASLLVHDDLVDGSDTR
                     RGAPSAHRRFEALLPGPRAARFGEAAAILLGDVLFSWSAEMFESAGLSPEAVRRAAPVL
                     ATMRSEVLLGQYLDVAAAFGATDRSTPRAQADTAEKVLEFKSARYSVRRPAELGATLGE
                     APPDLLAALGTYGSLLGRAFQLRDDLLGVFGDPDITGKPAGDDIREGKRTVLVLTALEN
                     GDARQRNTLESLLGSPGLTEEDLTTARDIIEATGARNSCEELIARSTTDALTALEGADM
                     DAEGRSALITLAGLATDRDR"
     gene            11406..12293
                     /locus_tag="E0E39_RS04230"
     CDS             11406..12293
                     /EC_number="1.5.1.20"
                     /GO_function="GO:0004489 - methylenetetrahydrofolate
                     reductase (NAD(P)H) activity [Evidence IEA]"
                     /GO_process="GO:0006555 - methionine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014847052.1"
                     /locus_tag="E0E39_RS04230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methylenetetrahydrofolate reductase"
                     /protein_id="WP_130873630.1"
                     /transl_table=11
                     /translation="MPPTVAELLRDAASPTLSFEFFPPRSPEEQPRFDASVAKLSRFHP
                     DFLSVTYGASGSTRDRTVAATAALGAAQHATIVGHLTCVSQSTDDLLRTLDAFAEAGVR
                     DILAIRGDMPGGPQQPWERHPDGLGNATELVRLIKGHGDFCVGVAAFPNVHQPDNDPEL
                     DARIVVEKAAAGADYAITQLFFESHRYVELVNRVRDRGSEIPIIPGIAPLTVITQIERF
                     ASLADCPLPDDFVAALRGARNPAEVRSIGLSRAINLCRELLAAGAPGLQFFTQNRWKAT
                     SEVLDAIGWGDRVS"
     gene            complement(12286..14469)
                     /locus_tag="E0E39_RS04235"
     CDS             complement(12286..14469)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014847051.1"
                     /locus_tag="E0E39_RS04235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="UvrD-helicase domain-containing protein"
                     /protein_id="WP_130873631.1"
                     /transl_table=11
                     /translation="MSTSRGDLQREIALEQAHVDRVYENLAASTASARTLARSGAEIYQ
                     TDRDDYLREESGTALFERDAFAYQAAKRLAILDAEHEGLVFGRLDLNFPETRYIGRLGV
                     RDAEYEPLVIDWRAPAAEPFYRATQATPMNVIRRRVLRCRDDNVIGLEDDLLDTSAETD
                     LPILGEGALMAALTRARGRTMRDIVATIQAEQDEAIRAPYQGVTIIGGGPGTGKTVVAL
                     HRAAYLLYTNRARLEKGGVLVVGPSSVFMNYIERVLPSLGEESVTLRAVGAVAGDVLGM
                     VSERVDAAPAATLKGSLRMLKVLRRLVRRPPIPAAEELRVSVKGEVLKLDALELAGIRE
                     SVLSNYKMNRGRAAATTSVARALAGKLTVDVGLDPEEVDERIRDHQRFREFMDSWWPML
                     DAPTVLARLADRELLDELAPDLTARERDDLAESYQWLQTGELEITGWSVADMALLDELL
                     EMLGPVPAGLHDEDPVFIDFGGISELVTTSDLMRREHVVDPDDDPQTTYAHILVDEAQD
                     ITPMQWRMLRRRGPQASWTLVGDPAQSSYPDTAEAERAVNDLVGRAPLRRFTLSTNYRS
                     PSEVFDLAAKVITKVFPDASLPRAVRNTGLVPKLTETDEAGLAETIIALTLGLAGHVSG
                     TVGIIVPPSRLVATTRLAMSDPRLAALEERLIVVTALQAKGLEYDGVLVVCPDEIVAEA
                     PGAERVLYVALTRATQRMTILDVGTSAWRAALS"
     gene            14604..15392
                     /locus_tag="E0E39_RS04240"
     CDS             14604..15392
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024853.4"
                     /locus_tag="E0E39_RS04240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DsbA family protein"
                     /protein_id="WP_130873632.1"
                     /transl_table=11
                     /translation="MNGQQQAEPGRGDPARPWKIATGLLAVAIVICLGVLSQATQNGRP
                     QGETSVASPGSTTVTPEATLRTADPSQEAEREAAIAKLARRQENDPMAKGRVDAPVVMI
                     EYADYRCPFCSVFAEETLPELQPLIDDGTLRIEFRDLAVFGDDSVAAAAAARAVGKQGM
                     FWEFQDALYRRLPNQGHPEVKDDLVMETATQVGVPDMVAFEADYRSEETRAAVRNETAE
                     GRRVGVNGTPFFFVGTRPVSGAQPLETFQQIIAQEKERLG"
     gene            complement(15552..16133)
                     /locus_tag="E0E39_RS04245"
     CDS             complement(15552..16133)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024701.4"
                     /locus_tag="E0E39_RS04245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_130873633.1"
                     /transl_table=11
                     /translation="MPRPRPHDDHLREQLLGIATDTIARTGTEGLSLRTLAADAGTSTS
                     AVYQLFGSRAALLDAVYLRVLEEFNRTQADAPMREDPIEDLLELARAYRRWALENRNQF
                     LVLVERITPSQKAVAGAAGRAVPVEDRVRRAMDKGALSGPLEQVVLSLWSTVHGYTALE
                     VAGVIAGSDDDFDAVARATQRAWHPATRER"
     misc_feature    16136..16147
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.08"
                     /tool="antismash"
     misc_feature    16155..16172
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.2"
                     /tool="antismash"
     misc_feature    16166..16182
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.08"
                     /tool="antismash"
     gene            16207..17742
                     /locus_tag="E0E39_RS04250"
     CDS             16207..17742
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="E0E39_RS04250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_061788395.1"
                     /transl_table=11
                     /translation="MTEEQNQNPPGGAPEEAVVASPRRWWILVALSLATIIIQFDQSGM
                     TLALPHIQAELGATTQQLQWVMDAYSLALASVVLTAGAVSDRYGRRKVFLLGIAVLAAG
                     SLIGALAPDANVVIAGRALMGVGGAMFMPGTLSIITHVFDRVTRPTAIGIWGAVTSLGV
                     IVGPLISGAVLQIWHWRGIFVLNVVMAAIAFTGAAALVPESRDPHPRRLDILGAVLAGA
                     GLLGVIYAVIHSSSDGVTSPVVLAAAGVGAAALVLFWLHSTRGEVSMFDLGVARNPAFL
                     GAALAAAVTMFTMAGLLFMITQQFQLVDGFGVLLAGVAVLPMAGGALVASLLVPLLVKR
                     LEVRTVVLLGLALMGAAAAAYGLAQPIRGYLPSLIVLILLGMGNGGVMVVSNDLLMSSG
                     PKSRSGLISSMNDTVQEVGTALGIAVLGAVLASQYAESLRRSMPGVADGSFTATLSDAG
                     TDSSVREAALAAFGDASRMAGLTAAGVVVLAVMVIAFTLRKVVAAKSGEDEED"
     misc_feature    16876..16878
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            17769..17975
                     /locus_tag="E0E39_RS04255"
     CDS             17769..17975
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="E0E39_RS04255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_041696537.1"
                     /transl_table=11
                     /translation="MALIHNDCRGLCDWHAAGELHDGLPLFRCNGCRSEWTPAERWTPI
                     NADGEMSEGVLAARAMPKVRRDR"
     tRNA            complement(18020..18105)
                     /anticodon=(pos:complement(986217..986219),aa:Leu,seq:gag)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="E0E39_RS04260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Leu"
     gene            complement(18020..18105)
                     /locus_tag="E0E39_RS04260"
     gene            complement(18186..19154)
                     /locus_tag="E0E39_RS04265"
     CDS             complement(18186..19154)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014847045.1"
                     /locus_tag="E0E39_RS04265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aldo/keto reductase"
                     /protein_id="WP_130873634.1"
                     /transl_table=11
                     /translation="MEYRALGGSGLHVSRIGLGTMAWGRDVEWPVVRELVHDFVEGGGN
                     LIDTAPAYGGGVAEQMIGKLLATGIPRDSLVIATKAGFIIRNGKRIIDTSRAALLSDLE
                     GSLRRLRTDHVDLWQVHAWGEAPVEETLSALDSAVSRGLARYVGVSNFVGWQTATAATW
                     QEAMAGRTKLASVQVEYSLLARRAEVEVIGAAQYHTLGLLAWSAMGRGALTGRYRRGIP
                     KDSRAASEHFGWFLEPYLQPRSRAVIDAVAKAADGLALTPAQVALMWVRDAPQVASALV
                     GPRTPDHLAELLEAETKQLVPPIVAALDDISGGPNQFRITD"
     gene            19311..19823
                     /locus_tag="E0E39_RS04270"
     CDS             19311..19823
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF022734.4"
                     /locus_tag="E0E39_RS04270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF3090 domain-containing protein"
                     /protein_id="WP_130873635.1"
                     /transl_table=11
                     /translation="MYEFPHPDRVVVGALGPVGERSFVIQIRQGEHMVAVGVQREAALS
                     IARRIDSLLREATALGWLGDPPEVEPELGPLDAPVDVLFNVGAIGWALDTRRGAIQLEF
                     YPDDQDVQGMAGLVQVWLYPGVARQFAARARIIVATADPSCPFCSQPVHAAGHICPRSN
                     GYRAPLF"
     misc_feature    20670..20684
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.15"
                     /tool="antismash"
ORIGIN
        1 gacttgacca gtttcaccgt gtcaccgcga tgccccgtgc cgtcggcggg gtcctgggag
       61 atgacctgtc ctgcggggac ggtgtccgag tgctcctcgg acacctcgac cgcgaacccc
      121 tgcttcttga gttccctgct ggcctggtcg gcgtcggttc ccctgtgatc cttgatggtg
      181 atgggctgac ggcccttgct gaccaccaga tcgatgctgc tgccgggtgg caggaggttt
      241 cccgctgatt caccggcgga gatgatcaga ccggtttcga cggattccga ccagtcctcc
      301 gtgacctggc cgacgaccag gtgcgctgat tcgatcgcgg agcgggcctg ggagagttcc
      361 tgccccacca cgtcgggcat catgtagcgc tcgggcccct tggagatgac gaccgtgacc
      421 ttggtgcctc gaagagcccg ggcgtttcct gcgggatcgg tgcttatgac cgatccgacc
      481 gcgacatcct cggagaaggc ctcctgggtg gtgtactcga gatcgttggc cctgaggctc
      541 tggagcgcct gttcctgggg aatgttggtc acctcggggg tggtggtgaa ccgcccctcg
      601 gcccaccacc acgagacgga gacgatgatc gccgtgacga gcagcaccag cacgagcaac
      661 atgatgccgc gacgacgccg gtacaccggc tcctgggaga actgcgggaa gatcggtgtg
      721 cggtgggagc tcggggaccc acctccgccg gagccgggaa gcgtggcacg gggaggtcct
      781 cccgtcgcgg aagcagcccc gaccggggaa accgagtgcg gtgagggcgc cgataccggg
      841 gaccggaggg gccccggcgc cacgatggcg gtcaccggac ggagaccctc ctcggccggg
      901 gcagtgtctg gcgaccggga acggggacgg gcgggagctc cttcagcggg cgtggacgcg
      961 gctcggggcg tggcgatatc tgctgggtgg cggcattgcc gtcgccgggc tggggtcgca
     1021 gctgggctgc gagcgcagga ttgtgctggc ccggggcgct caccagcgac ctgacgcagc
     1081 gcgtccatga gttcacgacc atcggcgatg cgagcctccg ggtcgcgtgc ggtgcaggcc
     1141 gccaccaggg catcgaggta gtccgggatg aaacccggaa atccgagctc gcgcagcttc
     1201 gcggaagggg cggggacgtc gacgttcacg tgcgcgtagg cgatctggta gttgttctcg
     1261 ccaacgtgcg gtttcttgcc ggtcagcaac tcgaacagga cgataccggt cgagtagatg
     1321 tcgctgcgcg aatccgggcg tgcgtgggtg accagctcgg gtggcaggta cgaggcggta
     1381 ccgaccagaa ccccggtggc ggtcatctgc ggggactcgg tctggcgcgc cagaccgaag
     1441 tccgcgacct tcacgtggcc gcgggtcgag atcatgacgt tctcgggttt gatgtcgcga
     1501 tggacgatac ccgcgtcgtg ggctgctgcc agagccgagg cgatgggttc caggtagtcg
     1561 agcgccagca ccggttcgag gggggcgtca cgggcgatga gcctgcgcag ggtctcacca
     1621 tcgatgaact ccatgacgat gtacggctgc ccccgggatg tgccctggtc gaagatactg
     1681 accaccgcgg ggtggttgat caatgcggcg gagcgggcct cccggtcgaa cttcgcggcg
     1741 aattcgtcat cctcggcaag gtcggttcgc atgatcttga ccgcgacggt cctctggaga
     1801 cgggcatcgc gcgcccggta gaccgtcgcc atgccgcccc gtgcgatctt cgcgagaatt
     1861 tcgtagcgac catccagcac gcttccgacc atcgggtcgt aggtactgct tttgttcacc
     1921 gcggtctcct ggggaaggta ggggatctgg gctgggcgat gagctcggcc ggtatcgagt
     1981 gtaggccgat cccggaacgg acgagttccg ggcacgccgc ataggcttct cgcatgacgg
     2041 tattgcgcag tctgcgttca cggatgctgc tggcacgcgt ggcggtgcag cttcccctga
     2101 ccgaggccga ggatcggcta ccgggactgg tcatggcagg gatcgacatg gcggtgctca
     2161 ccaccggcgg ccccgcagaa cacgaggcga acctgaggat cctgcgaaat ctcgaacgcc
     2221 acctcggcca gcgggtgctg ctggcggtcg acaccccgga gatcgatgcg gacgtgcggg
     2281 tttgtctccc gggcgagcgg gacaggtcgc gtccgcatcg gtgggcgctg ctcgggcagg
     2341 ttgtccagga gcgggggcag attgccgaac cggacgaggc cttccagttc ctggcggttc
     2401 ccgggatgcc tcccggttca ccgctgctgc gggccgcggt ggaggcccag cccccgctga
     2461 agcgggaatc ggttccctgg ttcgccgcgg gcggcctcga cgtcggatcc gttcaggtcc
     2521 tggcggactc gggcgtccgg cgggtctggc tcaccgaggg cggaaccgtg gcggcgctgg
     2581 aacggatcga cgagatcctg cggcgggcgt ggggcgggga tccggcctac gaggactacc
     2641 tggggttcgc ggtcggagtt tgaaacaccc cacgccaacc tgccgcggat tgctagtgtg
     2701 aggtttgcct acccttatgt atgaaggggt ccaccacatg accaatccac tgttcaaccc
     2761 gatatcaagg cgtgctttct ccggcctgtt cccggccctg ctggcgctgg gactcacggg
     2821 ctgcggatcc ggggcaacct ccggaggagg gaacgcctcg tcccccgcga gcgcccgcac
     2881 cattacccac gacctcggcg agaccgtcgt caacggcacc ccgaaacgga tcgtgtccac
     2941 ctccgtggtg ctcaccggca ccctcctggc cctggacgcg cccgtggtcg gctccggggc
     3001 gtcgaaaccg ggcgccgagg gattcgacga cgtcggtttc ttctcccact ggtcggccat
     3061 cgccaaggaa cgcggtgtca aggccgtcta cgcgaacagc aaactcgaca tcgaggccgt
     3121 gaccgcggag aaaccggacc tgatcatcat cgcttccacg ggaggggaca gcaccaagga
     3181 cgactatgac tcgctgtcca ggatcgctcc gaccgtcgcc atcaactaca actccgagag
     3241 ctggcagacc gtcacccggc aggtggccga cgtcaccgga acgcaggcca gggccgagga
     3301 gctcaccaac accttcaact cgaggctcac ggaactcaag gccgcaatgg gcggggttcc
     3361 caccgaggcg gtgcaggcca tcgtctacac cccctccaac ggcctgtcct tcgcgaaacc
     3421 gggcggcccc cacgacgaga tcttctcggc gctcggtttc aaactcgccg aggcgcccgc
     3481 cagcagcggt gaggaaggag ccaaccgcaa ggacttcgtg ttcgcgacgg tggagcagag
     3541 cgtgcaggcc ctgacctccg ataccctcct gctcgtctcc ggggacgaca agaccgtcga
     3601 acagctgaag gccgactcca actacaacac caccagaacc gtcagcagcg gcaggctggt
     3661 gccgctgggg atctccagct tcaaactgga ctactacagc gcgctcgcca tggccgagac
     3721 cctggctgcc gcctacccga ggtgagcaga gccgcctggg tgctgctcgg gctggcgatc
     3781 ctcctgccct gcctggtcct ggcgtcgttc ctgttcggat cgggcgatgt gccggccggg
     3841 caggtgttgg cggtgctctc cggcggcggc accggtgagc agcgcctcat cgtgctcggg
     3901 atgcgcggct cccggaccct gatagcgctg gtggccggcg ccgccctcgg gatcgccggg
     3961 gtgctggtgc aggcactgac ccgcaacccg ctggcggagc cggggctgtt gggggtcaac
     4021 gcgggcgcag cctgcgccgt ggcaatcggc ctcggtctcg tccggtccct gccgatcgcg
     4081 atgatgatgc tggtctccct ggcgggcgcg ctcctcagcg gactggtggt gaccggggcg
     4141 tcgggggcct ggcggggacg gcacgacccg attcgcatcg tgttggtggg ggccgcctgg
     4201 agcgcggtcg tctccgccat caccacgttc atgctgctca gcgatcccag gatctacgcc
     4261 gagttccgtt tctgggacgc gggggccgtg acgccgcggc cgctggatct ggtgatcgcc
     4321 gcggcgggaa cgctcggggt cgggctgctg gccgcgctcc tgctggcgag atccatggac
     4381 gccctggccc tgggggagga gttcgccaga ggactcggcc tcgcggccgg gcgggcccgg
     4441 atgctggtgg ccctcacctg cctggtgctc tgcgccgcgg cgacggccct ggtgggtccg
     4501 gtctccttcc tcgggctgat cgcgcccttc gcggcacggc tggtcgtcgg tccgaggcat
     4561 cgtgcgctga tctggttctc gaccctgctg ggtggggtga cgttgctggc cgccgacgtg
     4621 ctgggccggg tggtgaaccc gcccgccgag gtgcaggccg ccctgatgtg cgccctgctg
     4681 ggggcgccgt tgttcatcgg gctggcccgg gcgcgaaggc tggtgcagct gtgagcctgc
     4741 aggtgcgttc cgtgcggctc gggcccgtca gtttccacgc tcggccgaga acctggctgg
     4801 tcgcggctct ggcgtggggc atcgccctgg ccggggcgat cgcggtgctg ttctccggct
     4861 ccgtgaacat gacccccgaa cagttctggg cggccctggt cggggtgggg gaacgcgccg
     4921 acgtgctcct gctgtgggag ttccggatgc ccagggccct caccggcctg gtggtcgggg
     4981 cgtgtctcgg gacggcgggc tgcctgttcc aggcgctgtc gcgcaacgcc ctggggtccc
     5041 cggagatcat cggcctgacc ggcggcgcag cgctgggggc cgtggcctcc gtcatggtgt
     5101 tcaggtcctt cgggtggggc acggccgccg gggcgatcat cggttgcctg ggggccgccc
     5161 tgctcacctg ggtgctctca cccaggggat tcggcggcgg caaccgcctg atcctcatcg
     5221 gcctcggggt ggcctccctg atccaaccgg tgacggtgct gctgctcacc cgggccgaca
     5281 gcgactccgc gacctcggcc cggctgtggc tgaccggaac cctcaacgcc cgcaactgga
     5341 gccacgccgt ggtcggtgcc gtgctgttcg cggtgatcct gccgttcgcc ctgctgatct
     5401 cgcggcacct cgacgccgcc gccccgggag aggacttcgc cgccgggttg ggggtgtccc
     5461 gccgtttcac gcagtggacg gcaaccggcg tcggggtcgc gctgaccgcg gccgctgtcg
     5521 cggtggccgg tcccatcgcg ttcatcgcgc tcgccggccc acacgtggcc cgtcggctcc
     5581 tgaagggacc aaccgctccc gcgggcgtcg cggcgggcac gggggccgcg ctgctggtgg
     5641 cggcggacct ggtgggggcg aacctgccgg gcggcctgca gctcccggtg ggggtgacgg
     5701 ccggtctgct gggcggcgcc tacctgctgc tgctcctgaa cggacaggaa aggaagagat
     5761 gaccggaacc gcccaggagt tcccgctggc ggcctcgtcg gtgcggctcg gctacgaccg
     5821 gaagatcgtg atcgaggaca tcacgctgga ggtgcccgag ggggagctga cgatgctcat
     5881 cgggcccaac gggtgcggca agtcgacgct gctgaaggcc ctggcccggg tgctcgcccc
     5941 caaggccgga tacgtctacc tggggggaac cgacatccac cagctgcgaa ccaccgccgt
     6001 cgcccgcagg ctcgggttcc tgccgcaacg ccagtcggta ccgccgggca tcaaggtgct
     6061 ggacatggtg agccggggac gcttcgccca tcagaggttc tggtccaggt ggtcgcaggc
     6121 cgacgaggaa gccgtggcct cggccctgga ggtcaccgga ctgaccgatc tgcagcgggc
     6181 cgacgtcgac gagctctccg gcgggcaggt gcagcgggtg tggctggcga cggtgctggc
     6241 ccaggacaca ccgctgctgc tgctcgacga acccaccacc ttcctggaca tcgcccacca
     6301 gtacgaggtc ctgaaactgg tgcgcgggct ccgcgacgcc gggcgcaccg tcgtcgtggt
     6361 ggtgcacgac ctgaaccagg ccacccggtt cgccaccaac ctggtggtca tgaaggacgg
     6421 ggcgatcgtg gcctctgggt tgcccgccga ggtgctgacc gcggaactgg tcgagaacgt
     6481 cttcggactc ccggtgctcg tcgtgccgga cccggtcacc ggtgccccga tggtggtgcc
     6541 gcgatgacca cgcacctgct tcccacgccc ctgtccgcca cgggcgcccc gcatcccgcg
     6601 accccggagc tcccggaccg gttggaccgt tccccgatcg tggggaggcg gtgcgtgatc
     6661 gacggcgtgg agatggtgga ggtcaccttc gtcgcccacg aatccccggc acgtgaggtg
     6721 ctggtgcacg tcaacagcct gaccgacgcg atccgcaccc ggctgggtcc cgccatcatg
     6781 gcccctgtgg gaaacaccgg cgcgcagatc ctgtcctggt ggcttcccgc cgacggctgc
     6841 tactcctacc gctactggcg cagcgacgag gtgccccgcg acatcggtgc gacccgcgcg
     6901 ggctggatgc gggtgcaccg ggaggggcaa ccggacccgc tcaaccccga aaccctgccc
     6961 gccttcgacc tgcgggaaca gtcggtgtgg cgcgggcccg acttcgagcc cgttccctgg
     7021 gccccgaccg gtgaggccga gcggcagtgg cggctgcacg acgacggaag gttcgccgtg
     7081 ctgccgggcg atgaccggac cctggtgctg ttcgacgggc tccgctggcg cctggccggt
     7141 gtggcctccg cgctgcgggc cgcaggcctc gggcacaccg tcgtcgccgt cgacaccggg
     7201 gagggggagc agcgggccgc gtggctgacc acggctcggg gctgcgcccc gctggtggaa
     7261 cgcgcccggg aactggccgg ggcgggccgc gaggtgatcg ccgccggaca gtccttcggg
     7321 ggcctggcgt gcgtggagct cgcggtgcac cggccggatc tggtcaccgc ggtgatcgcg
     7381 cagtcggcgt cgctgtggtt cgcgggcgac cccgtcccgg aaccggatgc ggagggaatc
     7441 ctgctgcgcg gtctcgtcgc gggcacgagg gcgctgggga cgccggtggt ggtccaggcc
     7501 ggcaccgacg aacgcggcct gatccacgga gcccggcggc tggccgggat cgcggagagg
     7561 acaggccgac tggcagcggc ggaggagttc cgtggcggcc acgacctttc ctggtggcgg
     7621 cacggcctgc tgtcgggcct gtcagtcctc gtctgaacct cgccagatcc gtgccggctc
     7681 gccccggtgc ttggcggtca accaccacac gacctccacc agcccggccc cgatcagccc
     7741 ggccacgacc ccgaacagga tcgtcgacgg gttgtccagg tccagcagca gctggccgcg
     7801 cagccacgcc cacgggatca ggaacatggc gatgtagaag acgtaggaga cgaccaccag
     7861 gccgagtcgc caccacaccc acgggcgcgc caccacggca agcacccaga cggaggtgat
     7921 gatcagggca gccagggtgg cagtcgaggc ctgcgcctgc acgacgggcg acaccgcccc
     7981 gaaaccacgg gtgacgacgt aggtgatggt ggagaccgtt ccgatgatca cacccgaggg
     8041 caccgccagc gacaacacgc ggcgcacgaa acccggccgg gcgcgttcct tgttgggggg
     8101 cagcgacagc aggaaagcgg gaatgccgat ggtgaaccag ccgaccacgg tcatctggag
     8161 cgggatgaac gggttgggca ggcccatcaa cccgatcacc agggccagga agaccgcgta
     8221 caccgttttg ctgaggaaca gtttcgccac ccgctcgatg ttgccgatca cccgccggcc
     8281 ctcagccacc acgtgcggga gggtggcgaa ccggtcgtcg agcagcacga tctgcgcgac
     8341 tgcccgggtg gcgggggaac ccgagcccat cgcgaccccc aggtcggcgt ccttcagggc
     8401 gagcacgtcg ttgacgccgt caccggtcat ggcgacggtg tggccccggg actgcagggc
     8461 cgcgaccatg gcgcgtttct gctgcggggt gacgcgcccg aacacgtcgg ccccggcgat
     8521 cttctccgtg aactcctcgc cctcggcggg cagggtgcgg gcatccacgg cctcggccac
     8581 ggacaccccc agggaacggg tgaccgcacc gacggaggcc gcgttgtcac cggagatcac
     8641 cttcacggcc acgtgctgtt cgttgaaata ggcgagggtg tcggcggcgt cgggacgaac
     8701 cagctggtcc agcaccagca acgcgaccgg cgtgaccatc cccggcgcgc cgggagagtc
     8761 gacgggctcg gatgcgcggc ccagcagcag cacccggcgg cccgtcgagc cgatctcctc
     8821 cgcgcgggcg gccacgtcgg ccggggccag cacgtcgggc gcgcccagca cccaatcgcc
     8881 gcgcgtcccg aaggaaaccc ccgaccactt cttggcggag gtgaacggcg cccgggcggt
     8941 gacctcccac ggcgtcgagg ccgcgggggt ggcctcggcg atcgccgtca tcgacgcgtt
     9001 gggggcgggg tcggcggcga cgagctgcgc cagcaccccg gtgatctcgt cggcgtctcc
     9061 cgccaggggg atcacctctc cgagggtcat ggcgttctgg gtcagggtgc cggtcttgtc
     9121 cgcgcacacc acgctcaccc gggccaggcc ctcgatggcc ggcagttcct gcaccaggca
     9181 cttgcggcgc cccagccgga tcacacccag agcgaaggcc atcgacgtga gcagcaccag
     9241 gccctcgggg atcatcggca ccagggcgcc caccatccgc agcgccgatt cctgccaggt
     9301 ggtgcccggc tggcggaact gcacccagat ggtgagcaac cccgccggga tcagcagcca
     9361 ggtcacgaac ttcaggatgc ggtcgatgcc cgcccgcagc tcggagttga ccagcgtgaa
     9421 cttggcggcc tgcgcggtaa gctgcgcggc gtaggcctcg gcgccgacct tcgtggcccg
     9481 gtacacgccg gaaccggaaa cgacgaacgc ccccgacatg agttcgtcgc cgacggattt
     9541 ggccaccgga tcggcctcgc cggtcagcat cgactcgtcg acctccaggt agtcggcggc
     9601 caccacctcg ccgtcgacga ccacctggtc gcccggggac agcgcgatga ggtcgtcggc
     9661 caccacctgg tcccgtggca gggagatccg ctgcccgtcg cgcagcacga cgggatgggc
     9721 ctccccgatc acggccaggt tgtcgagggt gcgtttggcg cgcagctcct gcaccattcc
     9781 gatgatcgag ttggcgacga tcaggatcgc gaacgccccc tgggcgaact gcatggtcgc
     9841 ggcgacgatc acgaacaaca ccgccagcat cgcgttgacg cgcgtgaaca cgttgtcgcg
     9901 gacgatctgc caggtggtgc gccccgagcg ttccggcagc gtgttgaccc ttccctccct
     9961 gacccgttcc gccacctggt cggcggtcag gccccgcagc tcaccggtca cgatcggtgg
    10021 ccagtccggc gagtgtgatg agggccgagc gtccctctgc gtccatgtcg gctccttcca
    10081 gagcggtcag ggcatccgtg gtggaacggg cgatgagttc ctcgcaggag ttccgcgccc
    10141 cggtggcctc gatgatgtcc cgggcggtcg tgagatcctc ctcggtgagc ccgggggagc
    10201 cgaggaggga ttcgagggtg ttgcgctggc gggcatcgcc gttctccagg gccgtcagca
    10261 ccagcacggt gcgtttgccc tcccggatgt cgtcgcccgc gggtttgccc gtgatgtcgg
    10321 gatccccgaa gaccccaagg aggtcgtcgc gcagctggaa ggcccttccc agcagggaac
    10381 cgtaggtgcc gagagccgcg agcaggtccg gcggggcctc tcccagggtc gcgccgagct
    10441 cggcggggcg ccgcaccgag tagcgggcgg acttgaactc cagcaccttc tcggcggtgt
    10501 cggcctgggc ccgcggggtg gaacggtcgg tggccccgaa cgcggccgcg acgtcgaggt
    10561 actggccgag caacacctcg ctgcgcatgg tcgcgagcac cggggcggcg cggcgaacgg
    10621 cctccgggga aaggccggcg ctctcgaaca tctccgcgct ccaggagaac aggacatcgc
    10681 ccagcaggat cgcggcggcc tccccgaaac gggcggcccg ggggcccggg aggagagcct
    10741 cgaaacggcg gtgggccgat ggcgcgccgc gccgggtgtc ggagccgtcc accagatcgt
    10801 cgtgaaccag gagggaggcg tgcagcaggt cgagggaggc ggcggcgcgc agcagcggtc
    10861 ccggatccgt gggccgcccg gcggccacga cgtaccccca gtagcagaag gcgggacgca
    10921 gccgtttccc acccgcggcg tatacccgcg ccgcctccag caggggcaat gtgtcggtga
    10981 ggctcgcaag ttcgctctgg ccgtcgagga actcgatgag tgcccttccc accgccgaga
    11041 cgaaagctgg actcgtcggg tcgtgggcgg gggacgtcgg catgcgaccc agcttagagg
    11101 tcgcctcaac gggccggcgc aatttgatca aatccgggtg gggcgggccg cgacgtggga
    11161 tgctgctcgt gtctcgtgtc gaaaccattc tggatcaagc tggttgagcc ggcctgtgag
    11221 cgtcagcgag ccgggcgtgt ccaaaccatg gcggcagtgt tcgcagagct gcggtcgggt
    11281 ctgttgttcg ggtgctgggg tttcggttca gccgttcgct tcgctcagtg ctggctcaac
    11341 cggttcgggg agaaacggtg tcgtggttcg gtccagggcg cccgggtgct cgtatccttg
    11401 tcctcatgcc tccgaccgtt gccgagctgc tccgcgacgc cgcgtccccg acgctgagct
    11461 ttgagttctt cccaccccgc agccccgagg aacagccgcg cttcgacgca tccgtcgcga
    11521 agctgagccg gttccacccg gatttcctgt cggtcaccta cggggcctcc ggttccaccc
    11581 gcgaccgcac ggtggccgcg accgccgccc tgggagccgc ccagcacgcc accatcgtcg
    11641 gccacctgac ctgcgtgtcg cagtccaccg acgatctgct gcgcaccctc gacgccttcg
    11701 cggaggccgg ggtccgcgac atcctggcca tccgcgggga catgcccggc gggccgcagc
    11761 aaccctggga gcggcatccc gacgggctcg gcaacgccac ggaactggtg cggctcatca
    11821 agggacacgg cgatttctgc gtcggcgtgg ccgccttccc gaacgtccat caacccgaca
    11881 acgatcccga actggacgcc cggatcgtgg tggagaaggc cgcggcgggc gcggactacg
    11941 ccatcacgca actgttcttc gagtcgcacc gctacgtgga gctggtcaac cgggtccgcg
    12001 accgcggcag cgagatcccc atcatcccgg gcatcgcgcc gctcacggtg atcacccaga
    12061 tcgaaaggtt cgcctcgctc gcggactgtc ccctgcccga cgacttcgtc gccgcactcc
    12121 ggggcgccag gaaccccgcc gaggtgcgca gcatcgggtt gtcgcgtgcc atcaacctgt
    12181 gccgggagct cctggccgca ggggcccccg ggctccagtt cttcacccag aaccgctgga
    12241 aggccacctc ggaggttctc gacgccatcg gctgggggga ccgggtcagc tgagggccgc
    12301 ccgccaggcc gaggttccga cgtcaaggat cgtcatgcgc tgggtggcgc gggtcagggc
    12361 cacgtagagc acccgttccg caccgggggc ctcggcgacg atctcgtcgg ggcagaccac
    12421 cagcacgccg tcgtattcca ggcccttggc ctgcaacgcc gtgaccacga tgagacgttc
    12481 ctccagggcc gccagccgcg gatccgacat cgccagccgc gtcgtggcga ccagccgcga
    12541 gggcggcacg atgatgccca ccgttccgct gacgtgcccg gccagaccga gggtcaacgc
    12601 gatgatcgtc tccgccaggc cggcctcatc ggtttcggtg agtttcggga ccagaccggt
    12661 gttgcgcacc gcgcgcggca gactggcatc ggggaatacc ttggtgatga ccttcgccgc
    12721 caggtcgaag acctcggagg gggagcggta gttcgtggac agcgtgaaac ggcgcagcgg
    12781 ggcacggccc acgaggtcgt tgacggcccg ctcggcctcg gcggtatccg ggtaggagct
    12841 ctgcgccgga tcgccgacga gcgtccacga cgcctgcgga ccccggcgcc gcagcatccg
    12901 ccactgcatg ggtgtgatgt cctgggcctc gtccacgagg atgtgggcat aggtggtctg
    12961 cgggtcgtcg tcgggatcga cgacgtgttc gcggcgcatc aggtcggagg tggtcaccag
    13021 ttccgagatg ccgccgaaat cgatgaagac cgggtcctca tcgtgcaacc cggcgggtac
    13081 gggccccagc atctccagca gctcgtccag cagggccatg tcggccaccg accagccggt
    13141 gatctcgagc tcgccggtct gcagccactg gtaggactcc gccaggtcgt cgcgttcccg
    13201 ggccgtgagg tccggcgcca actcgtcgag cagctcccgg tccgccaggc gggccagcac
    13261 ggtgggggcg tcgagcatcg gccaccagga atccatgaac tccctgaacc gttggtggtc
    13321 gcggatccgc tcgtcgacct cctcggggtc gagacccacg tcgaccgtca gtttcccggc
    13381 gagtgcccgg gccaccgacg tcgtggccgc ggcgcggccg cggttcatct tgtagttgga
    13441 cagcaccgac tctcggatcc cggccagctc cagcgcgtcc agtttcagga cctcgccctt
    13501 gacgctgacc cgcagctcct cggcagcggg aatcgggggg cggcgaacca gtctgcgaag
    13561 caccttcaac atccgcagcg accctttgag ggtggccgca ggggcggcgt cgacccgctc
    13621 cgagaccatg cccagcacgt caccggccac ggccccgacc gcgcggagcg tcacggattc
    13681 ctcgccgagg ctcggcagca cccgctcgat gtagttcatg aacaccgagc tggggcccac
    13741 gacgagcacc ccacccttct cgaggcgggc ccggttggtg tacagcaggt aggcggcgcg
    13801 gtgcagggcc acgacggtct tgccggtgcc gggaccaccg ccgatgatcg tcaccccctg
    13861 gtagggggcg cggatcgcct cgtcctgttc cgcctggatg gtggccacga tgtcgcgcat
    13921 ggtgcggccg cgggcccggg tcagtgccgc catcaacgcg ccctccccga gaatcggcag
    13981 gtcggtttcg gcgctggtgt ccagcaggtc gtcctccagg ccgatgacgt tgtcgtcgcg
    14041 gcaacgcagc acgcggcgcc ggatcacgtt catgggggtg gcctgggtgg cgcggtagaa
    14101 cggttcggcc gcgggggccc gccagtcgat caccaggggc tcgtactcgg cgtcgcggac
    14161 accgagccgg ccgatgtaac gggtctcggg gaagttcagg tcgagccggc cgaagaccag
    14221 cccctcgtgt tccgcgtcga ggatcgcgag gcgtttcgcc gcctggtagg cgaaggcgtc
    14281 gcgttcgaac agggcggttc ccgactcctc ccgcaggtag tcgtcccggt cggtctggta
    14341 gatctctgcg ccgctgcggg cgagtgtccg ggcgctggcc gtggaggccg ccaagttttc
    14401 gtagacccgg tcaacatgtg cctgctccag cgcgatttcg cgctggagat cgcctctgga
    14461 agtgctcaag ggcggtaatc ctcactcctg ggatggacgc cccactctac tccgttcgga
    14521 gccccccgaa cgccacttgg gatcaacggt gaatgcaccg tactctcttg ttccgacaca
    14581 accggaggac gtgaggggga ccgatgaacg ggcaacagca ggcggaaccg ggcagaggcg
    14641 atcccgctcg cccgtggaag atcgcgacgg ggctcctggc cgtcgcgatc gtgatctgcc
    14701 tgggggtgtt gagccaggcc acgcagaacg ggagaccaca gggcgagaca tccgtggcct
    14761 ccccgggttc gacgacggtg acgcccgagg ccaccctgcg gaccgcggac ccgtcacagg
    14821 aggccgagcg ggaagccgca atcgcgaaac tggccaggcg ccaggagaac gatccgatgg
    14881 ccaaggggcg ggtcgacgcc cccgtggtga tgatcgagta cgccgactac cggtgcccgt
    14941 tctgttccgt gttcgccgag gaaacgctcc cggaactgca gccgctgatc gacgacggaa
    15001 ccctgcggat cgagttccgt gacctcgcgg tcttcggcga cgactccgtc gcagccgccg
    15061 cggccgcccg ggccgtgggg aagcagggca tgttctggga gttccaggac gccctctaca
    15121 gaaggcttcc caaccagggg catcccgagg tcaaggacga cctcgtcatg gagaccgcca
    15181 cacaggtcgg ggttccggac atggtggcct tcgaggccga ctaccgttcc gaggagaccc
    15241 gggccgcggt caggaacgag accgcggagg ggcgtcgggt gggtgtcaac gggacgccct
    15301 tcttcttcgt cggaacccgt ccggtctccg gcgcccaacc cctggaaacc ttccagcaga
    15361 tcatcgcgca ggagaaggag cggctcggct gatggtgagc ggtttcgcag gctcgttcct
    15421 cgggggctcg cggctccttc ctgcgtcacc gccggcatcg gtggcctgac acccagcggt
    15481 ggtttcccga actggagagc ctgctgcgcg cggagcgcgg gcatccccga cccgatggcc
    15541 ggcgggatcg ttcaccgttc gcgggtggcc gggtgccagg cgcgctgggt ggcccgggcg
    15601 acggcgtcga agtcgtcatc ggagcccgcg atcacgcctg cgacctcgag agcggtgtag
    15661 ccgtgcacgg ttgaccacag tgacaacacg acctgttcca gaggacctga gagcgcgccc
    15721 ttgtccattg ccctcctgac gcgatcctcg acgggaaccg cgcggcccgc cgccccagcg
    15781 accgccttct ggctcggggt gatccgttcc accaggacga ggaactggtt tctgttctca
    15841 agggcccagc gtctgtaggc gcgggccagc tccaggaggt cctcgatcgg gtcctcgcgc
    15901 atcggggcgt cggcctgggt ccggttgaac tcctccagga cccgcaggta gaccgcatcc
    15961 agcagcgccg cacgactgcc gaagagctgg tagaccgcgc tggtcgaggt gccggcatcc
    16021 gcggcaaggg tgcgcaggga gagaccctcg gtgccggtac gggcgatcgt gtcggtcgcg
    16081 atgccgagca gctgctcgcg cagatggtcg tcgtggggcc gcggtcttgg catgtgaaaa
    16141 gggtaacgac gaatatgcta taacagcgtt atataacatc gttacacaat gttggaggta
    16201 gacagggtga ccgaggaaca gaaccagaac ccgccaggcg gggccccgga agaagctgtt
    16261 gtcgcgtcgc ccagacgctg gtggatcctg gtcgccctgt cgttggcgac gataatcatc
    16321 cagttcgacc agtccggaat gacgctggca ctgccgcaca tccaggcgga gctcggggcc
    16381 accacccagc agctgcagtg ggtgatggac gcctactcgc tggccctggc ctcggtggtg
    16441 ctcaccgcgg gggcggtctc ggaccgttac gggcgccgta aggtgttcct gctcgggatc
    16501 gcggtgctcg cggcgggttc cctgatcggg gcgctcgctc ctgacgcgaa tgtcgtcatc
    16561 gctggccggg ccctcatggg tgtcggcggt gcgatgttca tgcccggcac cctctcgatc
    16621 atcacccatg tcttcgaccg cgtcacccgc ccgaccgcga tcggtatctg gggtgccgtg
    16681 acatccctcg gggtgatcgt cgggccgctg atctccggtg ccgtgctgca gatctggcac
    16741 tggcgcggca tcttcgtcct gaacgtggtg atggctgcta tcgccttcac gggagcggcg
    16801 gcgctggttc cggaatcgcg cgacccgcac ccgcgtcgcc tggacatcct cggggccgtt
    16861 ctcgccggtg ccgggttact cggcgtcatc tacgccgtca tccactcctc ctccgacggc
    16921 gtcaccagtc ccgtggtgct ggccgcggcg ggcgtcgggg ccgcggcgct ggtgctgttc
    16981 tggctgcatt cgaccagggg agaggtgagc atgttcgacc tcggggtggc gaggaacccg
    17041 gcgtttctgg gggcggccct tgccgcggcg gtaaccatgt tcacgatggc aggcctgctg
    17101 ttcatgatca cccagcagtt ccagctcgtc gatggcttcg gggtgcttct ggccggggtc
    17161 gcggtgttgc caatggcagg tggtgccttg gtcgcatccc tgctggtccc gctgctcgtg
    17221 aaacgtctcg aggtgcgtac cgtcgtcctg ctcggcctgg cgctgatggg tgcggccgcc
    17281 gccgcgtacg gcctggcgca gcccatccgc ggctacctgc cgtccctgat cgtcctgatc
    17341 ctgctcggta tgggcaacgg gggcgtgatg gtcgtgtcca acgacctgct catgtcgtcg
    17401 ggtcccaaga gcagatccgg gttgatctcc tccatgaacg acacggtcca ggaggttgga
    17461 accgccctcg ggatcgctgt gctgggggcc gtgttggcga gccagtatgc cgaatccctt
    17521 cgtcgttcga tgcccggggt ggctgatggc tcattcaccg caaccctttc cgacgcaggg
    17581 acggattcct cggtgcggga ggcggcgttg gcggctttcg gggacgcgtc ccggatggcg
    17641 gggctgacgg cggccggggt cgtggtgctg gccgtcatgg tgatcgcctt cactctcaga
    17701 aaagtggtgg ctgcgaagtc cggagaggac gaggaggact gagtccttga gcgactaacc
    17761 tgctcctcat ggctctgatt cacaacgatt gccgaggctt gtgcgattgg catgccgccg
    17821 gggagctcca cgacgggttg ccgttgttcc ggtgcaacgg gtgtcgttcg gaatggaccc
    17881 cggccgaacg ctggaccccg atcaacgccg acggcgagat gtcggagggg gtactggccg
    17941 cgagggccat gcccaaggtt cgcagggacc ggtgaacgaa aaagcccgct cgactctgcg
    18001 aacgggctca atcaaaaagt gtccgagaga ggacttgaac ctccacgccc tgaaacgggc
    18061 actagcacct caagctagcg cgtctaccta ttccgccacc cggacccggg tcacccccac
    18121 atcagtgggc gcgacgagaa acgatagcag gcggccggag gggatcgcaa ccgagatcgc
    18181 cgggttcagt cggtgatccg gaactggttc gggccgccgg agatgtcgtc gagggcggcg
    18241 acgatgggtg gtaccagctg cttggtctcg gcctcgagga gttcagccag gtgatccggg
    18301 gttctggggc cgaccagggc gctcgccacc tgtggggcgt cacgaaccca catcaacgcc
    18361 acctgcgccg gcgtgagcgc cagtccgtcg gcggccttgg cgacggcgtc gatcacggcc
    18421 cggctccggg gctggaggta cggctccagg aaccagccga aatgctcgga ggcggcccgt
    18481 gaatccttag ggatgccccg gcggtagcgg cccgtcaatg cgccccggcc catcgccgac
    18541 cacgccagca gaccgagggt gtggtactgc gccgcgccga tcacctccac ctcggcgcga
    18601 cgtgccagca gtgagtactc cacctgcacc gaggccagct tcgtacgtcc cgccatcgcc
    18661 tcctgccagg tggcggccgt ggcggtctgc catccgacga agttgctcac cccgacgtag
    18721 cgggccagtc cgcgcgagac tgcggagtcg agagccgaca gggtctcctc gacgggggcc
    18781 tccccccagg cgtgcacctg ccacaggtcg acgtggtccg tgcggagcct gcgcagcgat
    18841 ccctcgaggt cgctcagcag cgccgcgcgg gaggtgtcga tgattctttt cccgtttcgg
    18901 atgatgaaac cggccttggt ggcgatgacc agggagtcgc gcgggatccc cgtggccaac
    18961 agctttccga tcatctgctc ggcgactccg ccgccgtagg cgggggccgt gtcgatcagg
    19021 ttcccaccac cctcgacgaa gtcgtggaca agttcgcgaa ccaccggcca ctcgacgtcc
    19081 ctaccccagg ccatcgttcc caggccgatc ctggagacgt gcagcccaga tccgccgagt
    19141 gcccgatatt ccattcgggc agtctaggtc gcggtttccc cgggatgctt gaagcacgcc
    19201 ggtgagcgag ggagctgcgg tgaccacggc gggaccccgg cccgggattc ccggaccacc
    19261 ccgagcccct ggtgcaagca ggttcacatc cccgtagtgt ggggtgagtg atgtacgaat
    19321 ttcctcaccc cgaccgcgtg gtcgtcggtg ccctcggtcc tgtcggggaa cggagcttcg
    19381 tcatccagat ccgtcagggg gaacacatgg tcgccgtcgg cgtccagagg gaggctgcac
    19441 tgtccattgc ccgccgcatc gactccctgt tgcgggaggc gacggctctc gggtggttgg
    19501 gcgacccccc ggaggtcgag cccgagctcg gtccgttgga tgcccccgtt gacgtgctgt
    19561 tcaacgtcgg ggccatcggg tgggccctcg acaccaggag gggagccatc cagctcgagt
    19621 tctaccccga cgatcaggac gtgcagggga tggccggcct ggttcaggtg tggctgtacc
    19681 ccggggtggc caggcagttc gccgcgcgcg cccggatcat cgtcgcgacc gccgacccca
    19741 gctgcccgtt ctgctcccag ccggtgcacg ccgccgggca catctgcccc cgcagcaacg
    19801 ggtaccgcgc accgctgttc tgacccggca ctccgccgat tccggtgttg atttccggga
    19861 ggggcgccga aaggcagtag ttttgtggcc atgtattcgt gggccccagt cgagataccc
    19921 agcatcccgc cgtcgcagga cgtgcccaag cagctcaggc tgtacgactc ctcctccgcc
    19981 cgcaccattc ccgtcggacc cgtggagggt acggcccgga tgtacgtgtg cggaatcact
    20041 ccttatgacg ccacacacct gggtcacgcc aacacctacc tcaccttcga tctggtgaat
    20101 cgtgtctggc gggacctcgg cctggacgtc aactacgtcc agaacgtcac ggatgtggat
    20161 gatccgctgc tggaacgcgc cgccgcaacg gggcaggact gggaggaact ggccgaggac
    20221 cagaccgagc tgttccgctc cgacatgacc gcgctgcggg tcatcccgcc cgaccgctac
    20281 gtcggggcgg ttgaatcgat tccgtgcgtg gtggaactga tcgagaagct gctgcccacc
    20341 gggctggtct atcaggtgga ggatccggat cacccggact ggtacttcaa tgctgcgagt
    20401 gctcccggtt tcggggaggt cagtcactac gacgaggaac gcatgctcaa gatcttcgcc
    20461 gagcgcggcg gggatcccga tcgccccggt aaacgccatc cgttggactg cctgctgtgg
    20521 cggttcgcgc gctccgggga acccagctgg acctcggcac tcggtgatgg gcggcccggc
    20581 tggcacatcg agtgcaccgc catctccctg caccatctcg gtccctgctt cgatctgcag
    20641 ggtgggggaa ccgacctggt cttcccgcat cacgagatgt gtgccgcaga ggcgcaggcc
    20701 gtgacgggag cgccgatggc cagcgcttac gtccactccg gaatggttgg gctcggtggg
    20761 cggaagatga gcaagtcgag gggcaacctg gaactggtga gcaggctcag gcagcgcggg
    20821 gccgatccca tggcgatccg gctggcgctg ctcggccagc actaccgcag cgactgggag
    20881 tggagcccgc aactgctgga acgcgccacg cgacgtctcg gtgtgtggcg ttccctccgt
    20941 gacttccggg ccacccggcc cacggaagag atcgtcgccg aggtccggcg tgccctgcgc
    21001 aacgacctgg atgccccgct ggcgctcgac atcatcgatg aatgggcaac ggcgagcatc
    21061 gaatccgggg gggaggaaac cga
//
