LOCUS       NZ_LS483425            22835 bp    DNA     circular CON 13-FEB-2024
DEFINITION  Streptococcus pyogenes strain NCTC13737 chromosome 1, complete
            sequence.
ACCESSION   NZ_LS483425
VERSION     NZ_LS483425.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1
  AUTHORS   Doyle,S.
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (08-JUN-2018) WTSI, Pathogen Informatics, Wellcome Trust
            Sanger Institute, CB10 1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/13/2024 01:17:44
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,756
            CDSs (total)                      :: 1,667
            Genes (coding)                    :: 1,613
            CDSs (with protein)               :: 1,613
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 54
            CDSs (without protein)            :: 54
            Pseudo Genes (ambiguous residues) :: 0 of 54
            Pseudo Genes (frameshifted)       :: 32 of 54
            Pseudo Genes (incomplete)         :: 27 of 54
            Pseudo Genes (internal stop)      :: 25 of 54
            Pseudo Genes (multiple problems)  :: 24 of 54
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:29:05
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1555684
            Orig. end                         :: 1578519
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LS483425.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22835
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="6"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22835
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22835
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12835](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12835)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    170..185
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.39"
                     /tool="antismash"
     misc_feature    522..540
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 22.7"
                     /tool="antismash"
     gene            916..2496
                     /locus_tag="DQN36_RS07825"
                     /old_locus_tag="NCTC13737_01548"
     CDS             916..2496
                     /EC_number="2.1.1.72"
                     /GO_function="GO:0009007 - site-specific
                     DNA-methyltransferase (adenine-specific) activity [Evidence
                     IEA]"
                     /GO_function="GO:0015666 - restriction
                     endodeoxyribonuclease activity [Evidence IEA]"
                     /GO_process="GO:0006306 - DNA methylation [Evidence IEA]"
                     /GO_process="GO:0009307 - DNA restriction-modification
                     system [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982804.1"
                     /locus_tag="DQN36_RS07825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01548"
                     /product="type I restriction-modification system subunit M"
                     /protein_id="WP_111704341.1"
                     /transl_table=11
                     /translation="MAEKTTSLRQALWHSADQLRGQMDANDYKNYLLGLIFYKHLSDKL
                     LLAVCDNLEKHFNTFTEAQKIFEDAYQDEDLKDDLISVVTGDLGYFIEPTLTFEKLIQD
                     VYHNTFQLESLAQGFRDIEQSGEDFENLFEDIDLYSKKLGSTPQKQNQTISNVMKTLNE
                     IDFEAVDGDTLGDAYEYLIGEFASESGKKAGEFYTPQAVSHLMTQIVFLGREDQKGMTL
                     YDPAMGSGSLLLNAKKYSNQSDTVSYYGQEINTSTYNLARMNMMLHGVAIENQHLSNAD
                     TLDADWPTDEPTNFDGVLMNPPYSLKWSATAGFLTDPRFSSYGVLAPKSKADFAFLLHG
                     FYHLKNTGTMAIVLPHGVLFRGAAEGKIRQKLLEQGAIDTIIGLPSNIFYNTSIPTTII
                     ILKKNRTNKDVFFIDASKEFDKGKNQNTMTDSHIKKILDAYKSRDNSDKFSYLASFDEI
                     IENDYNLNIPRYVDTFEEVPVKPLPELAKQLSDIDQEIAKTNAKLDQLMKQLVGTTKEA
                     QDELDTFRN"
     gene            complement(2706..2906)
                     /locus_tag="DQN36_RS09300"
     CDS             complement(2706..2906)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002988115.1"
                     /locus_tag="DQN36_RS09300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_011018219.1"
                     /transl_table=11
                     /translation="MPDMKSFLNLVKQKLFKPGLKKLVKLHNSQNVNICLYINDWNYFM
                     VRTMVFVEGSKVVLKISLNRV"
     gene            complement(3048..3653)
                     /locus_tag="DQN36_RS07835"
                     /old_locus_tag="NCTC13737_01549"
     CDS             complement(3048..3653)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057302.1"
                     /locus_tag="DQN36_RS07835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01549"
                     /product="response regulator transcription factor"
                     /protein_id="WP_002982799.1"
                     /transl_table=11
                     /translation="MKILLIDDHRLFAKSIQLLFQQYDEVDVIDTITSHFNDVTIDLSK
                     YDIILLDINLTNISKENGLEIAKELIQSTPHLKVVMLTGYVKSIYRERAKKVGAYGFVD
                     KNIDPKQLISILKKVDSGKKYFEQIESQDYVESLTDQEIAILNLSKKGFSIKEIEETLQ
                     ISRRTVFNHLTHIYSKLLVNNKQEAIYKAEQLGYFMDF"
     gene            complement(3634..5196)
                     /locus_tag="DQN36_RS07840"
                     /old_locus_tag="NCTC13737_01550"
     CDS             complement(3634..5196)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000619317.1"
                     /locus_tag="DQN36_RS07840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01550"
                     /product="hypothetical protein"
                     /protein_id="WP_111704342.1"
                     /transl_table=11
                     /translation="MIRIKNITKSKFFGTAIILLQQLIALLILVYNRENLSLLFSEKVA
                     LVMTLIDTAFIWLATILHQKQGDIFKRIIFIISLTIWQYLVSVLTRGTPLFLSSGLQII
                     LLYCYTVEITNVILYGHKQFKDKLDKGLLIIIFVSITSLFVNRILFNFLFLMVFTILHL
                     YPLLVIVLYYRSFRQQISVVRRSLILFSLLLLVILGSELYGEMLDVNQAFNNLGWYLFP
                     LIMSVIYYFKTIHDKLSFVTQRWLGDYKARIELLFLLLILCWVVLIKVLVKEFLLFFII
                     VDASTLFCLVVISCIFYYLENSKQNFDYENRRLNYFMKSEENMRVEFSNYLHDDVLQNI
                     IAIKNLLSLENSNITHGFIVNELNDLVSGIREEIDTYHPIVPANQTMKENIQSLFDDIV
                     KSRKSNTLLYFNCSDNMVVPSPYGDIVYRFIKELINNAIKYGDGKDIRLSLTIQSDIII
                     IEESNQVVEKVHSINYGRGLKSFQETLAAFDGDLELQMDTKQFTIRILLPIDWKLCYED
                     FIN"
     misc_feature    complement(5162..5182)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 26.44"
                     /tool="antismash"
     gene            complement(5236..7143)
                     /locus_tag="DQN36_RS07845"
                     /old_locus_tag="NCTC13737_01551"
     CDS             complement(5236..7143)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1243: ABC
                     transporter, permease component"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012561001.1"
                     /locus_tag="DQN36_RS07845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01551"
                     /product="FtsX-like permease family protein"
                     /protein_id="WP_111704343.1"
                     /transl_table=11
                     /translation="MIWSITKSNIKKNFSLYRIYFLATIGLLSIFIAFLNFISDKIITE
                     KIGDSGQALVIANGSLIFLIVFLVVFLIYFNNFFVKKRSQELGVLAILGFSKRELTKLL
                     TLENLVILVLSYLVSLLLGPTLYFLAVLAITHLLNLTMEVQWFITVNEIIESLGILVVV
                     FLINVITNGLIITKQSLIEFVNFSRKAEKKIKIRKVRAIIAITALLLSYILCLATVFSS
                     TRNMLLSIGMVPVSLLIIVLVVLGTVFTIRYGLAFVVSLLKGNKKRLYRPLSNIIYPKF
                     NYRIATKNKLLTVLGGLLTVTVSVAGMMVMLYAYSLNGIERLTPSAIEYNVESENGQVN
                     VTTILENDQVSLVDVDLLRLNTNPEVTITESGQTIPYFDIINYSDYKELMKAQGRINSI
                     EGSKSLPLLINYYPTEISLGKTFNVGNAYDVTVKQVSTNNVFSFSTSVTTLVVSDKLYA
                     KLSSCFPEKEMTIRTFNGNSIRSSEAFYNQFSMVPDVISSYSKEYTVKTANIATYIFIT
                     FLSILFIICTGSILYFTSLIEIMENKEEYGYLSKLGYSKKMIHRILRYETGILFLIPVF
                     IGIVNGGMLLIYYKYLFMDTLVAGNIIMLSLLLCLLFFLIIYGTFYVLTLRSVTSIIKN
                     "
     gene            complement(7145..7882)
                     /locus_tag="DQN36_RS07850"
                     /old_locus_tag="NCTC13737_01552"
     CDS             complement(7145..7882)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000812013.1"
                     /locus_tag="DQN36_RS07850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01552"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_111704344.1"
                     /transl_table=11
                     /translation="MKQLVLKDVCKKYPNQLNYALDHINLIVEKGEFVAVMGRSGSGKT
                     TLLNVTSIIDKIDSGNIYCADKEVSTFSDKEATNFRKNDIGFVFQDYMLLDSLTIRENI
                     SVALSLKNIDSSKIDDLINSYAKRFNLYEQLKKYPYQLSGGQRQRVSIIRAIIKEPEII
                     FADEPTGALDLKSSEGTMRILSEINKTEKVTILMVTHDVLSASYADRVILLKDGKLHME
                     IDKKDCGESFYDVISQALSDRGE"
     gene            complement(7879..10023)
                     /locus_tag="DQN36_RS07855"
                     /old_locus_tag="NCTC13737_01553"
     CDS             complement(7879..10023)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002887183.1"
                     /locus_tag="DQN36_RS07855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01553"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_111704345.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 2.5e-22, bitscore:
                     75.8, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKITPIEQTTPTECGLCCLYMMLDYFDIPETYFKLKQQVNLGRN
                     GLSIKNISDIASIYGVTCKTYRFSKYPENLPVMVFVSDSHFVILEDIRDDAFTIVDPAV
                     GKYVLAKNEFFELSPKFYTEFFYDKATNSSKKIAKRGLVGRNVKEMIFVNRKDTFLTIL
                     YTLIFQIITVSIPFFIRGIIDGNWVFLKKFGYLESAVLLSIIIFFQGGFYFLKNISLVK
                     LQNKFHSTISEKFVTKLLKLPIEYIGKIDKTDIIHRYNGLMIVRELLSERIISIWLDII
                     LMFASISYITYVSTPLGVILGIVFIVEMMIFFLSLSIKQEKLGKEVLRQKNSLQTFFSL
                     MDGLFLFKAKNSEKELLSKWDKSFKDYINSTYDRNRYFNLLGAVNYVITFSIPILLILL
                     FLYYSPNSSSGELILLYMMVLNIINPINNILNSIDEILYGVKHYERVLEISTLDDETNG
                     TYKLSEDTDIEINLENINYQYELNGAEVLNGINLKVHSGEFVAIIGKSGSGKTTLAKML
                     LGYVSPSSGDITYNNISYSKIDKTDFRNISAFVSQDSPIFDGDVMYNISLGRESVSGEQ
                     VIETCKRVSIYDDIRSMPMKFHTPLFRDNPSLSGGQKQRISLARELVTTPRILVLDEPT
                     SALDVKTERIIQKNVEALHCTRILVTHRLNTVEKADKILIMDNGKIIDYGNHHYLYKNN
                     KDYCDLYDSYMNKYQEEEVK"
     gene            complement(10001..12835)
                     /gene="lanM"
                     /locus_tag="DQN36_RS07860"
                     /old_locus_tag="NCTC13737_01554"
     CDS             complement(10001..12835)
                     /GO_process="GO:0009403 - toxin biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0018081 - peptide cross-linking via
                     lanthionine or 3-methyl-lanthionine [Evidence IEA]"
                     /GO_process="GO:0018193 - peptidyl-amino acid modification
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="lanM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032491806.1"
                     /locus_tag="DQN36_RS07860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01554"
                     /product="type 2 lanthipeptide synthetase LanM"
                     /protein_id="WP_111704346.1"
                     /sec_met_domain="DUF4135 (E-value: 3.5e-82, bitscore:
                     273.2, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2e-79, bitscore:
                     263.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKRNELKLEYQQHQFYEYFNSIFDYDILDTSISENIYLLREKTH
                     KLFYSEFENQLFETIMFLSMKTLVLDINHFSKEIENKSKAYEQYIQQIREENGISNFFD
                     RYPYLLKQINREVGLVVESYSLLFDRFLKDLSEIRSCFNISEPLSNVAFSLGDSHSKKQ
                     TVVKIAFKEKSVYYKPKSYHSHSILLELTSLLKSSNIPSFSLPKSLVKADYCWQLGVAY
                     TSSNKDEVAKIYFKYGVLAAFSEIFSITDLHMENVIVSGGDLYLIDVETFFQRKLNVQN
                     QNFEGITVDTYQRIYETSLSNGLFPVQFEKNSAPNVSGISGKGGKRKKGKYELINKNRG
                     DMKLVKTDYFQEDGYNIPTLNGKVVEPLDYANEVIAGFRECYTFLMSQRAKVKKILEDF
                     PKLKTRVIFRNTSDYGKFLQASTNPKYLFSEKKRENLFSILHESKHIEQFIVVSEIKDL
                     MNGDIPYFSMDTSGNVYNSLGTVIGNLGETTSLFDNIATLNDERMKFTCELLGIVLKKP
                     IKHWEREKGKSYQFLSISSEHNFSEEILDSIRRIFIDADKNSFSSEEEITWLNIDITET
                     EQWVISPQNITLYNGLIGNALGYLYAYQILGEEQYLVSLNKILKTLETTKNLIETSDMS
                     VFLGKGGLIYLYFSLWKRLKLPQYQKLYLDIIKEFSSQSLEEQNIDYISGVSGLLVVLC
                     NIYNVEQNKTVYHLINRISEFIIDNVKKEDDKVYWVSDFSDSEILNGLSHGQSGIAYAL
                     LLSWKINKNYNYFKIAKSAIDFENTRISDGNWIDFRNKGKRSELGMPEPIYWCHGATGI
                     GLTRYRESKWLNDKELKNNYEMAKQTVLNNGYLNSDCLCHGKMGNMELFMNLDDSLKNE
                     VDIEGIILNIVRNSQKFGWESGLPQHTRVFNMMVGEIGIAYQLLRYISNYEVPSLLLLD
                     VPKGSIENEKDYTD"
     gene            complement(12917..13072)
                     /locus_tag="DQN36_RS07865"
                     /old_locus_tag="NCTC13737_01555"
     CDS             complement(12917..13072)
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) lacticin_mat"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982773.1"
                     /locus_tag="DQN36_RS07865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01555"
                     /product="type A2 lanthipeptide"
                     /protein_id="WP_002982773.1"
                     /sec_met_domain="L_biotic_A (E-value: 6.9e-19, bitscore:
                     64.1, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="lacticin_mat (E-value: 5.2e-06, bitscore:
                     23.0, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFMKNSKDILTNAIEEVSEKELMEVAGGKKGSGWFATITDDCPN
                     SVFVCC"
     CDS_motif       complement(12986..13072)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSFMKNSKDILTNAIEEVSEKELMEVAGG"
                     /locus_tag="DQN36_RS07865_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(12917..12985)
                     /prepeptide="core"
                     /locus_tag="DQN36_RS07865_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="4.40"
                     /molecular_weight="2306.6"
                     /monoisotopic_mass="2305.1"
                     /core_sequence="KKGSGWFATITDDCPNSVFVCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSFMKNSKDILTNAIEEVSEKELMEVAGG"
                     /leader_location="[12985:13072](-)"
                     /alternative_weights="2324.6"
     gene            complement(13575..14981)
                     /gene="lacG"
                     /locus_tag="DQN36_RS07870"
                     /old_locus_tag="NCTC13737_01556"
     CDS             complement(13575..14981)
                     /EC_number="3.2.1.85"
                     /GO_component="GO:0009341 - beta-galactosidase complex
                     [Evidence IEA]"
                     /GO_function="GO:0004565 - beta-galactosidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006012 - galactose metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="lacG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002290548.1"
                     /locus_tag="DQN36_RS07870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01556"
                     /product="6-phospho-beta-galactosidase"
                     /protein_id="WP_063629613.1"
                     /transl_table=11
                     /translation="MTKTLPKDFIFGGATAAYQAEGATHTDGKGPVAWDKYLEDNYWYT
                     AEPASDFYNRYPVDLKLSEEFGVNGIRISIAWSRIFPTGKGEVNPKGVEYYHNLFAECH
                     KRHVEPFVTLHHFDTPEALHSDGDFLNRENIEHFVNYAEFCFKEFSEVNYWTTFNEIGP
                     IGDGQYLVGKFPPGIQYDLAKVFQSHHNMMVSHARAVKLFKDSGYSGEIGVVHALPTKY
                     PFDANNPDDVRAAELEDIIHNKFILDATYLGKYSDKTMEGVNHILEVNGGELDLREEDF
                     AALDAAKDLNDFLGINYYMSDWMQAFDGETEIIHNGKGEKGSSKYQIKGVGRRKAPVDV
                     PKTDWDWIIFPQGLYDQIMRVKADYPNYKKIYITENGLGYKDEFVDNTVYDDGRIDYVK
                     KHLEVISDAISDGTNVKGYFMWSLMDVFSWSNGYEKRYGLFYVDFETQERYPKKSAYWY
                     KKVAETQVIE"
     gene            complement(15069..16766)
                     /locus_tag="DQN36_RS07875"
                     /old_locus_tag="NCTC13737_01557"
     CDS             complement(15069..16766)
                     /EC_number="2.7.1.207"
                     /GO_component="GO:0019197 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase complex [Evidence IEA]"
                     /GO_function="GO:0015155 - lactose transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002263057.1"
                     /locus_tag="DQN36_RS07875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01557"
                     /product="lactose-specific PTS transporter subunit EIIC"
                     /protein_id="WP_111704347.1"
                     /transl_table=11
                     /translation="MNGLIAQIEKGKPFFEKISRNIYLRAIRDGFIAGMPVILFSSIFI
                     LIAYVPNAWGFHWSKDIENLLMTPYNYSMGILGLFVAGTTAKALTDSMNRSLPSTNQIN
                     FISTMLAAIVGFLLMAANPAKDGGFLTGFMGTKGLLTAFIAAFITVNVYKTCVKNNVTI
                     RMPEEVPPNISQVFKDLIPFTLSVVLLYVIELIVHTTLGVNVAESIGKLLAPLFQAADG
                     YVGITIIFGAFAFFWFVGIHGPSIVEPAIAAITYANAETNLQLLQAGEHADKILTSGTQ
                     MFIVTMGGTGATLVVPFMFMWLTKSKRNKAIGRASVVPTFFGVNEPILFGAPLVLNPIF
                     FIPFILAPIVNVWIFKFFIDTLGMNSFTANLPWTTPAPLGLILGTNFQVLAFILAALLI
                     VVDVIIYYPFLKIYDEQILAEEAAGTNSSDALKEKVAANFDTKKADAILEKSAAKETKK
                     ITDQTNVLVLCAGGGTSGLLANALNKAAKEYGAPVTAAAGSYGAHREILPQYQLVILAP
                     QVASNYEDMKVETDKLDIKLAKTEGAQYIKLTRDGQGALDFVKAQFEN"
     gene            complement(16766..17083)
                     /locus_tag="DQN36_RS07880"
                     /old_locus_tag="NCTC13737_01558"
     CDS             complement(16766..17083)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730102.1"
                     /locus_tag="DQN36_RS07880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01558"
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="WP_111704348.1"
                     /transl_table=11
                     /translation="MNREETTLLGFEIVAYAGDARSKFLEALKASQEGDYAKAEELIAA
                     GSDCLNDAHNAQTSLLQKEAAGDDLAYSVTLMHGQDHLMTTILLQDLMKHMIELYKRGA
                     K"
     gene            complement(17107..18090)
                     /gene="lacD"
                     /locus_tag="DQN36_RS07885"
                     /old_locus_tag="NCTC13737_01559"
     CDS             complement(17107..18090)
                     /EC_number="4.1.2.40"
                     /GO_function="GO:0009025 - tagatose-bisphosphate aldolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019512 - lactose catabolic process via
                     tagatose-6-phosphate [Evidence IEA]"
                     /codon_start=1
                     /gene="lacD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017768297.1"
                     /locus_tag="DQN36_RS07885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01559"
                     /product="tagatose-bisphosphate aldolase"
                     /protein_id="WP_111704349.1"
                     /transl_table=11
                     /translation="MTITLTENKRKSMEKLSVDGVISALAFDQRGALKRMMAQHQTKEP
                     TVEQIEELKSLVSEELTPFASSILLDPEYGLPASRVRSEEAGLLLAYEKTGYDATTTSR
                     LPDCLDVWSAKRIKEAGAEAVKFLLYYDIDGDQDVNEQKKSYIERIGSECRAEDIPFYL
                     EILTYDEKISDNASPEFAKVKAHKVNEAMKVFSEERFGVDVLKVEVPVNMKFVESFADG
                     EVLFTKEEAAQAFRDQEASTDLPYIYLSAGVSAKLFQDTLVFAAESGAKFNGVLCGRAT
                     WAGSVKVYIEEGPQAAREWLRTEGFKNIDELNKVLDKTASPWTEKM"
     gene            complement(18094..19023)
                     /locus_tag="DQN36_RS07890"
                     /old_locus_tag="NCTC13737_01560"
     CDS             complement(18094..19023)
                     /EC_number="2.7.1.144"
                     /GO_function="GO:0009024 - tagatose-6-phosphate kinase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019512 - lactose catabolic process via
                     tagatose-6-phosphate [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1276: PfkB domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018379688.1"
                     /locus_tag="DQN36_RS07890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01560"
                     /product="tagatose-6-phosphate kinase"
                     /protein_id="WP_111704350.1"
                     /transl_table=11
                     /translation="MILTVTLNPAIDVSYPLDELKCDTVNRVIDVTKTPGGKGLNVSRV
                     LNEFGETVKATGCIGGESGDFIINHLPDSILSRFYKISGDTRTCIAILHEGNQTEILEK
                     GPMLSVDEIDGFTHHFKYLLNDVDVVTLSGSLPAGMPDDYYQKLIKIANLNGKKTVLDC
                     SGNALEAVLKGDSKPTVIKPNLEELSQLLGKEMTKDFDALKEVLQDKLFDGIEWIIVSL
                     GADGVFAKHKDTFYNVDIPKIKIVSAVGSGDSTVAGIASGLANDEDDRALLTKANVLGM
                     LNAQEKTTGHVNMANYDKLYQSIKIKEV"
     gene            complement(19069..19584)
                     /gene="lacB"
                     /locus_tag="DQN36_RS07895"
                     /old_locus_tag="NCTC13737_01561"
     CDS             complement(19069..19584)
                     /EC_number="5.3.1.26"
                     /codon_start=1
                     /gene="lacB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012027025.1"
                     /locus_tag="DQN36_RS07895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01561"
                     /product="galactose-6-phosphate isomerase subunit LacB"
                     /protein_id="WP_111704351.1"
                     /transl_table=11
                     /translation="MKIAVGCDHIVTYEKVAVVDYLKSQGHKVIDCGTYDNVRTHYPIF
                     GKKVGEAVASGEAELGVVICGTGVGITNAVNKVPGIRAALVRDMTSAIYSKEELNANVI
                     GFGGKIIGGLLMNDIIDAFLAAEYKPTEENKKWIEKMDSLQHASQDQNNPHFFDEFLEK
                     WDRGEYHD"
     misc_feature    19550..19565
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.35"
                     /tool="antismash"
     gene            complement(19619..20047)
                     /gene="lacA"
                     /locus_tag="DQN36_RS07900"
                     /old_locus_tag="NCTC13737_01562"
     CDS             complement(19619..20047)
                     /EC_number="5.3.1.26"
                     /codon_start=1
                     /gene="lacA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982747.1"
                     /locus_tag="DQN36_RS07900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01562"
                     /product="galactose-6-phosphate isomerase subunit LacA"
                     /protein_id="WP_002982747.1"
                     /transl_table=11
                     /translation="MAIIIGADKAGQELKEVIKDYLKEGKYEVVDVSENEVRDFVDTTL
                     AVAKEVNASEDNLGIVIDAYGVGSFMVATKIKGMVAAEVSDERSAYMTRGHNNARIITL
                     GSEISAPGIAKNIIKGFVEGKYDGGRHQVRVDMLNKMC"
     misc_feature    complement(20033..20048)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: medium, score: 24.28"
                     /tool="antismash"
     misc_feature    20200..20213
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.23"
                     /tool="antismash"
     misc_feature    complement(20201..20214)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 24.03"
                     /tool="antismash"
     gene            20492..21265
                     /locus_tag="DQN36_RS07905"
                     /old_locus_tag="NCTC13737_01563"
     CDS             20492..21265
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004270277.1"
                     /locus_tag="DQN36_RS07905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01563"
                     /product="DeoR/GlpR family DNA-binding transcription
                     regulator"
                     /protein_id="WP_111704352.1"
                     /transl_table=11
                     /translation="MKKKERHEKILDILKVDGFIKVKDIIDEMNISDMTARRDLDTLAD
                     KGLLIRTHGGAQYLDYSSAKDDGHEKTHTEKKVLQTTEKKQIAQRAKNIIKDGETVFIG
                     PGTTLEHLAVELKNRNIRVITNSLPVFLILHPSTTIDLILIGGECREITGAFVGAIAIN
                     NLESLTFSKAFVSANAVYNNSIATYSDLEGEVQRVALNNAVEKILLVDSTKFESYDFYN
                     FYQLDQVDLIVTDKNVTTDIIEKYKKFSKIIIADK"
     misc_feature    complement(21823..21841)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 23.24"
                     /tool="antismash"
     gene            21897..22202
                     /locus_tag="DQN36_RS07910"
                     /old_locus_tag="NCTC13737_01564"
     CDS             21897..22202
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002988079.1"
                     /locus_tag="DQN36_RS07910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01564"
                     /product="hypothetical protein"
                     /protein_id="WP_111704353.1"
                     /transl_table=11
                     /translation="MKGLHKTTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRL
                     FLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQGKFYTSEEVRAELGL"
     gene            22192..22527
                     /locus_tag="DQN36_RS07915"
                     /old_locus_tag="NCTC13737_01565"
     CDS             22192..22527
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003048651.1"
                     /locus_tag="DQN36_RS07915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01565"
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_111704354.1"
                     /transl_table=11
                     /translation="MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMKQIISDI
                     EKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKDYIVLYHIEGEENRVVIDYLLPTQS
                     DYIKLFK"
ORIGIN
        1 gggcgtggag ttgctgctat aaaaggtaat gaatttatct ttcaaatatt aaaatacttg
       61 aaagaaattg gttattggaa aagaattagt acaggttcaa cttttgataa cattagctct
      121 agtgatatca aatatgctaa aattcaaatt ccctccctcc ctgaacaaga agccattggc
      181 gaacttttcc aaacggttga tcaattgatt cagttgcagg atcaaaagct agcaaccctt
      241 aaagaacaaa agcaaacctt cctcagaaag atgttcccac ctcaaggaca aaaagtccct
      301 gaaatccgtt tacaaggttt tgatggtgag tgggaagaga agaaattggg ggaaatatct
      361 actcatagaa gtggaacggc aattgaaaaa tattttgatt cggaaggtga atttaaagtc
      421 atttcaatag gtagttatgg aactaataac ctctatgtag accaaaatat tagagcagtc
      481 tcaaatgaac ttactaattc taaattagtt gcctccggtg aattaacaat ggtactcaat
      541 gataagacag cgaatggggc aataatcgga agatgtctac ttattacaga aaataataaa
      601 tatgttgtta atcaaagaac agaaattatt agaccagata ttaatatttc ctcttactat
      661 cttttccatt atttaaatgg tgaatttcgt aatggtatca ttaaaattgc tcaaggtggc
      721 actcaaatct atgtaaatta ttcatctgtt gaacaattaa agataaatat acctacatta
      781 aaagaacaag aagctatcgg tgacttcttc caaaccttag accaacaaat gagtcaaaca
      841 gaagataaat taatagaact taaagcactc aaacaaacat tactcaatcg tttattcgta
      901 taagaaagga cgcacatggc agagaaaaca acttcactcc ggcaagcact atggcattcg
      961 gccgatcaat tacgtggcca aatggatgcc aatgactata aaaactatct tcttggactt
     1021 attttttaca aacacttatc tgataaatta ctcttggctg tttgtgataa tttagaaaaa
     1081 cactttaata cctttacaga ggcccaaaaa atctttgaag atgcttatca agatgaagac
     1141 ctaaaagatg acctcatttc tgttgttact ggtgatttag gttactttat cgaaccgaca
     1201 ctgacctttg aaaaactcat ccaagatgtt tatcacaata ctttccaatt agaatcatta
     1261 gctcaaggtt ttcgcgatat tgaacaaagt ggtgaagact ttgaaaactt atttgaagat
     1321 attgacctct actctaaaaa attaggctct actcctcaaa aacaaaatca aaccatttct
     1381 aatgtcatga aaacattaaa tgaaattgac tttgaggcag tagatgggga tactttaggc
     1441 gatgcttatg agtacttgat tggtgaattt gccagtgagt caggaaaaaa agcaggtgag
     1501 ttctataccc cacaagctgt ctctcacttg atgactcaaa ttgtcttttt aggccgtgaa
     1561 gatcaaaaag gaatgaccct ctatgaccct gctatgggat ctggatcact ccttttaaat
     1621 gctaagaaat atagtaacca atccgatacc gtttcttact atggtcaaga aatcaatact
     1681 tctacttata acttggctcg tatgaacatg atgcttcatg gcgttgccat cgaaaaccaa
     1741 cacttaagta acgctgatac cttggatgca gactggccaa cagatgaacc aaccaacttt
     1801 gatggggtgt tgatgaaccc accttattct ttgaaatggt cagcgactgc tggtttctta
     1861 acagatccac ggttttcaag ttatggtgta ttagcaccaa aatcaaaagc tgactttgcc
     1921 tttttacttc atggtttcta tcatttaaaa aatacaggaa ctatggcgat tgtcttacca
     1981 cacggtgttc ttttccgtgg agctgcagaa ggcaagattc gccaaaaact actcgaacaa
     2041 ggggctatcg ataccattat cggactccca tcaaatatct tttataatac aagcatccct
     2101 acgactatta tcatattaaa gaagaacaga accaacaaag atgtcttctt tatcgatgct
     2161 tcaaaagagt ttgataaagg caaaaatcaa aacacaatga cagatagcca tatcaaaaag
     2221 atccttgatg cttataagag tcgtgataat tctgataagt tttcatattt agcctcattt
     2281 gatgaaatca ttgaaaatga ctataactta aatatcccac gctatgttga tacctttgag
     2341 gaagtccccg tcaaaccact gccagaatta gctaaacagc tcagtgacat tgatcaagaa
     2401 attgccaaaa caaatgccaa actagatcaa ctcatgaaac aactagtcgg aacaaccaaa
     2461 gaagcacaag acgaattgga tacttttaga aactaaaaga caaaaaaaca ccacagtaga
     2521 tgattactac tgtggcgttt tatttaaaat tgagtagtga acctttattg agtacttatc
     2581 atacaagatt ctccttcttc acctataaat caaaatagaa tcatctcatc taactttgtc
     2641 cgtttctttg ttttatttaa aatagttatt tgaagttaca atgatttctc aaacgtttag
     2701 aaagcttaaa cacggttaag agaaattttc aggacaactt ttgatccttc cacaaaaacc
     2761 atggtgcgaa ccataaagta gttccaatcg ttgatatata agcatatatt aacgttctgg
     2821 gagttgtgaa gctttacgag tttttttaga cctggtttaa acaacttttg tttgactaaa
     2881 tttaaaaagc ttttcatatc aggcatttcc ctacttttta taaaagcgtt atctcaatca
     2941 atttcaatca aaaagaactc aaaaacaatg agtttaaatc tgggtattta acaggaaatc
     3001 cctagcaacg acacaagtaa aacttatgtc gtttgattat ctgcaactca gaaatccata
     3061 aaatacccta attgttcggc tttgtagata gcctcttgct tattatttac caaaagcttt
     3121 gagtagatgt gggtcaaatg attaaatact gttctcctac taatttgtaa cgtttcctct
     3181 atttctttta tagagaatcc tttcttactc aaatttaaga tagctatttc ctggtcagtt
     3241 aaagattcaa cataatcctg agattcgatt tgttcaaaat acttttttcc agaatccact
     3301 ttttttaaga tagaaatgag ttgtttaggg tctatatttt tatctacaaa accgtatgct
     3361 cctacttttt ttgccctctc tctatagatt gatttaacat atcctgtcaa cataacaact
     3421 ttcaaatgag gagtagactg tatgagttct tttgctatct ccaatccatt ttctttagaa
     3481 atatttgtta aattaatatc aagcaatata atatcgtact tagacaaatc aatcgtcaca
     3541 tcgttaaaat gagaagtaat cgtatctatg acatctactt catcatactg ttggaataac
     3601 agttggatac tctttgcaaa tagtctgtgg tcatcaatta ataaaatctt cataacacaa
     3661 tttccaatct atgggaagta atattctgat agtaaattgt ttagtatcca tttgtagttc
     3721 tagatctcca tcaaaagctg ctagtgtttc ttgaaatgat ttcaatcctc tgccataatt
     3781 tatagagtgt actttttcca ctacttgatt gctctcctca atgataataa tatcagattg
     3841 aatcgttaaa gataaacgaa tgtcttttcc atctccatat tttatagcat tgtttattag
     3901 ctcttttata aacctataaa caatatctcc atatggggat ggcactacca tattatctga
     3961 acagttaaaa tacaataagg tattactttt tctactttta acaatatcat caaaaagaga
     4021 ctgtatgttt tctttcattg tttgattagc gggaactatt gggtggtaag tatcaatttc
     4081 ttctctgata ccagaaacta aatcattcaa ctcattaaca ataaaaccat gtgttatatt
     4141 actattttct agagaaagca agttttttat cgctatgata ttttgtaaaa catcatcatg
     4201 caaataattt gagaactcca ctctcatgtt ttcctctgat ttcataaaat agttcagtct
     4261 tctattttca tagtcaaaat tttgtttgga gttttctaaa taataaaaga tgcaagaaat
     4321 taccactaga caaaataacg tgcttgcgtc aacaattata aaaaataata aaaattcttt
     4381 aactagtacc tttatgagta caacccaaca aaggataaga agtagaaata atagttctat
     4441 acgagctttg taatcaccta accatctttg ggtaacaaaa ctcaatttat catgtatggt
     4501 cttaaaatag tatattacac tcattataag gggaaacaga taccatccca aattattaaa
     4561 ggcttgatta acatctagca tttctccata aagttcacta ccaagtatta ccagcaaaag
     4621 taaagaaaat agtatcaatg aacgtctaac aactgatatt tgttgcctaa aggacctata
     4681 atatagcact ataactagta acggatacag gtgtaagata gtaaaaacca tcaggaataa
     4741 aaaattaaat aaaattctat taacaaaaag gctagttata gaaacaaaaa taattattaa
     4801 caagccctta tctaacttat ctttaaattg tttgtgccca tataatatta cattagtaat
     4861 ctcaacggta taacaataga gcaatataat ctgtagtcca ctgcttaaaa agagaggagt
     4921 tcctcttgtc agcacagata ctaagtattg ccaaattgtt aaggagatga taaaaataat
     4981 tcttttaaaa atatcacctt gtttttggtg taatattgtt gccagccaaa taaaagctgt
     5041 atcaataagg gtcattacaa gagctacttt ttcagagaaa agaagagaca ggttctctcg
     5101 attatagacc aaaattaaca aggctattaa ttgttgcaac aagattattg cagtcccaaa
     5161 gaacttactc tttgttatgt tttttattct tatcatatta tttacttaat cgttaaagtt
     5221 aaaagatttt taaaattaat ttttgattat ggatgtcact gaccgcaatg tcaatacata
     5281 aaatgtgcca tatattatca agaagaaaag cagacaaagc aataaagata acattatgat
     5341 attgcctgct accaatgtat ccatgaataa atatttatag taaataagca acataccacc
     5401 atttacaatc ccaatgaata caggaataag gaaaagtata cctgtttcat atcgaagaat
     5461 ccgatgaatc atttttttac tataacctag cttacttaga tagccatatt cttctttatt
     5521 ttccatgatt tcgatgaggc ttgtaaagta cagaatacta cctgtacaaa taataaagag
     5581 tatggatagg aaagttataa agatataagt cgcaatatta gcagtcttta ctgtgtattc
     5641 cttactataa ctactgataa catcaggaac catactaaac tgattgtaaa atgcttcact
     5701 tgacctaatc gaatttccat taaaagtcct aattgtcatt tctttctctg gaaaacaaga
     5761 actaagttta gcatataatt tatcagaaac aaccaaggtc gtgacacttg tagaaaaact
     5821 aaaaacatta ttcgttgata cttgttttac agtaacatca tatgcatttc ctacgttaaa
     5881 ggtttttcca aggctaattt ctgttggata ataatttatt aacaatggga gtgacttact
     5941 accttcaata gaatttattc tcccttgagc tttcattaac tctttgtagt cactgtagtt
     6001 aattatatca aaataaggaa ttgtttgccc agattctgta atagttactt ctgggttagt
     6061 gttcaatctc aataggtcaa catcaaccaa gctcacttgg tcgttctcta aaatagttgt
     6121 aacattgact tgaccgtttt ctgattcaac attatattct atggcagatg gagtcaacct
     6181 ctctatccca ttaagagaat aagcatagag cattaccatc attccggcaa ctgaaacggt
     6241 tactgttaaa agacctccca agactgttaa taatttattt tttgttgcaa tacgatagtt
     6301 aaatttggga tagatgatat tagacagagg acggtataac ctttttttat ttccttttaa
     6361 taacgaaact acaaaagcca atccatatct gatggtgaac actgttccta aaacaactaa
     6421 gacaattatc aatagagaaa ccggtaccat ccctatgctt aatagcatat ttcgtgtgga
     6481 tgaaaacact gtcgccaaac ataaaatata tgacaatagc aatgcagtga tagcaataat
     6541 agctctgact tttcttatct taattttttt ctcagccttt cttgagaaat taacaaactc
     6601 aatcaaagac tgtttagtaa tgataagtcc atttgtgatg acattaatca gaaaaactac
     6661 gactaatatt cctaaagact ctataatctc attaactgta ataaaccact gaacttccat
     6721 tgttaaattc aatagatgag taattgccag tacagctaaa aaatataaag tcggtcccag
     6781 caataaactt accaagtaac tcagaactag aataacaaga ttttctaaag ttagtaattt
     6841 tgttaattct ctttttgaaa accctagtat tgctaagact ccaagctctt gactacgttt
     6901 ttttacaaag aaattattga agtaaattaa gaataccacc aaaaatacaa tcaaaaaaat
     6961 caatgaccca ttagcgataa ctagagcttg accactatcc ccaatttttt ctgtaatgat
     7021 tttatctgag ataaaattta gaaaagctat aaaaatactt aataaaccaa tcgtagctag
     7081 aaaatagata cgatataacg aaaaattttt tttaatgtta gattttgtaa ttgaccaaat
     7141 catattactc tcctctatcg gataaagctt gactaattac atcgtaaaac gactctccac
     7201 aatctttttt atcaatctcc atgtgaagtt tcccatcttt gaggagtata actctgtcgg
     7261 cataagaagc tgataaaacg tcatgagtaa ccattaaaat agttaccttt tctgttttat
     7321 tgatttcact caaaatcctc attgttcctt cagaagattt taagtcaagt gctccagttg
     7381 gttcgtcagc aaaaataatc tctggttctt taatgattgc tctgataata ctgaccctct
     7441 gtctttgacc tccagaaagt tgatacggat atttcttcaa ctgttcatat aaattaaatc
     7501 tttttgcata gctatttatc aaatcatcaa tctttgaaga atcaatattt tttagagaca
     7561 aagcaacaga aatattctcc ctaatggtta gactatctaa cagcatataa tcttgaaaaa
     7621 caaaaccaat atcatttttt ctaaaattag ttgcctcctt atcagagaat gtgctaacct
     7681 ctttatccgc acagtaaata ttcccactat caattttatc aataattgaa gtaacattta
     7741 aaagcgtcgt tttcccacta ccgctacgcc ccatgacagc tacaaattct cctttttcca
     7801 caatcaaatt gatatggtct agagcataat tcagttgatt gggatatttt ttgcaaacat
     7861 cttttaatac taattgtttc attttacctc ttcctcctga tatttattca tatacgagtc
     7921 atataagtca caataatcct tattattttt gtacaaataa tgatggtttc catagtcaat
     7981 aattttacca ttatccatta ttaaaatctt atcagctttt tcaactgtat taagtctgtg
     8041 ggtaaccaaa atcctcgtac aatgtaaagc ctcaacattt ttttggatta ttctttcagt
     8101 ttttacatct aaagctgatg taggttcgtc aagaactaag attctagggg tggttacaag
     8161 ttctcttgct aaagaaattc gttgtttttg ccccccagat agtgatggat tatctcgaaa
     8221 aagtggtgta tgaaacttca ttggcatact cctgatatca tcatatattg ataccctttt
     8281 acaagtttca ataacctgtt ctcctgaaac agattctctc cctagcgaaa tgttatacat
     8341 cacatcccca tcaaatatgg gagaatcttg agatacaaaa gccgatatat tcctaaaatc
     8401 agttttatca attttagagt aggatatatt gttgtatgtg atgtctccac tactagggct
     8461 tacatagcct aacaacatct tagctagagt tgtctttcca cttccacttt tccctataat
     8521 tgcaacaaat tctcctgaat ggacttttag gtttattcca tttaacacct ctgccccatt
     8581 taactcatat tgatagttta tattttctaa atttatctct atatctgtat cctctgatag
     8641 cttataagtg ccattcgtct catcatcaag agttgatatc tctaataccc tttcgtaatg
     8701 cttaacacca tatagaatct catcaatcga attcaaaata ttattaatgg gattaataat
     8761 atttaaaacc atcatataaa gaagaataag ctcaccactg ctactatttg gtgaataata
     8821 tagaaataac agaattaaca aaataggtat ggaaaaagtt atcacataat ttactgctcc
     8881 taaaagattg aaatatctat ttctatcata tgttgaattg atatagtcct taaaactttt
     8941 atcccatttt gacaaaagtt ctttttcaga atttttagct ttaaaaagaa atagcccgtc
     9001 catcagtgaa aaaaatgttt gtaaagagtt cttttgtctt aaaacttctt tacctaactt
     9061 ttcttgttta atgcttagtg ataggaaaaa aatcatcatt tctacaataa aaactatacc
     9121 caatataact cccaaaggtg tagaaacata tgtgatataa ctaatactcg caaacattaa
     9181 gataatatcc aaccagatag aaataattct ttctgatagt aactccctca caatcatcaa
     9241 accattatat ctatgaatga tgtctgtttt atctattttt ccaatatatt ctatgggaag
     9301 tttcaataac ttagtcacaa acttttctga aatagtgctg tgaaatttat tttgcaattt
     9361 cactaaagag atattcttta gaaaataaaa tcctccctga aaaaaaatta ttatagaaag
     9421 taggactgca ctttctaaat agccaaactt tttaaggaaa acccaatttc catcaataat
     9481 tccccttata aaaaatggaa ttgacactgt gataatctga aaaatcagag tatatagaat
     9541 ggttaaaaaa gtatccttcc tatttacaaa tatcatttcc tttacgtttc tgccaactaa
     9601 tcctcgtttg gctatttttt ttgaagaatt agtcgcctta tcataaaaaa attcggtata
     9661 aaatttagga gataattcaa aaaattcatt ctttgctaag acatatttcc caacagcagg
     9721 gtcaacaata gtaaaggcat catcacgaat atcctctaaa attacaaaat gcgaatctga
     9781 aacaaatacc atgacaggta agttttcggg atatttggaa aaacgataag tcttacaagt
     9841 aactccgtag atagaagcaa tatctgagat attctttata ctcagtccat ttctccctaa
     9901 attgacttgt tgtttcaatt taaaatatgt ttctggaata tcaaaataat ctaacatcat
     9961 atataaacaa cataatccac attcagtagg agttgtttgt tcaatcggtg taatcttttt
    10021 cattttcaat actccctttt ggaacatcta ataacaataa tgatggtact tcataattgg
    10081 atatatatct aagtaactgg tatgctatcc ctatttcacc aaccatcata ttaaacactc
    10141 ttgtgtgttg tggcaagcca gattcccaac caaatttttg agaattacga acaatattaa
    10201 gtatgatacc ttctatatct acttcatttt tcaaggagtc atctaaattc ataaataatt
    10261 ccatgttgcc cattttcccg tgacaaaggc aatccgaatt caaataacca ttatttaata
    10321 ccgtttgttt agccatttca taattatttt tcaactcttt atcgtttaac cattttgatt
    10381 ctctatatct cgttaatccg atacctgttg caccatgaca ccaataaata ggttctggca
    10441 ttcctaactc tgaacgtttt cctttattcc taaaatcaat ccaatttcca tcagaaatac
    10501 gggtattttc aaaatcaata gctgacttcg ctattttaaa ataattataa tttttattga
    10561 ttttccatga taaaagtaat gcatatgcaa tcccagattg tccgtgagat agtccattta
    10621 gaatttctga atctgaaaaa tccgataccc aataaacctt atcatcttct tttttcacat
    10681 tatcaataat aaattcagat atcctattaa ttaaatgata tactgtttta ttttgctcta
    10741 cattatatat gttgcacaga acaactaata aaccagacac tccagaaata taatctatat
    10801 tttgctcctc tagtgactgg ctggaaaatt ctttgattat gtctaaatat aatttttggt
    10861 attgaggtaa tttaagtctt ttccacaaac taaagtatag ataaatcaaa cctccttttc
    10921 ccaaaaaaac tgacatatca ctagtttcta taagattctt tgtggtttcc aatgttttca
    10981 atatcttatt taatgatact agatattgct cttcaccaag aatttgataa gcatataaat
    11041 aacctaaggc attcccaatc aatccattat acaaggtaat gttctgagga gatattaccc
    11101 attgctcagt ctctgtaata tcaatattga gccatgttat ctcctcctct gaagaaaagc
    11161 tattcttatc tgcatcaata aatattcgtc taatgctgtc taagatttcc tcactaaaat
    11221 tgtgttctga ggagattgat aaaaactgat aagatttgcc cttttccctc tcccaatgct
    11281 taatcggttt tttcaagact attccaagca attcgcaagt gaacttcatt ctttcatcat
    11341 tcagggtagc tatattatca aataatgagg ttgtctctcc tagatttcca attactgttc
    11401 ctaaagaatt atatacattt ccactggtat ccattgaaaa gtaaggaata tcaccattca
    11461 tcaaatcttt aatttcacta acaacaataa attgttcaat atgttttgac tcatgtagta
    11521 tcgaaaataa attctccctc tttttttctg agaaaagata ttttggattc gtagaggctt
    11581 gtaaaaattt tccatagtcg gaagtatttc tgaatatgac tctagttttc aattttggga
    11641 aatcttctaa aattttttta acctttgcac gttgcgacat gagaaatgta tagcattctc
    11701 taaaacctgc aattacctca ttagcatagt cgagaggttc caccactttc ccatttaatg
    11761 tcggaatatt ataaccatct tcctgaaaat agtcagtttt cactaacttc atatctccac
    11821 gatttttatt tatcagttca tactttccct tttttctttt cccacctttt ccacttatcc
    11881 cagaaacgtt aggagcgctg tttttctcaa attgtacagg aaataaacca tttgaaagtg
    11941 atgtctcata aattctctga taggtgtcta cagtaatccc ttcaaaattc tgattttgta
    12001 cattcaactt tctttgaaaa aatgtttcaa cgtcaattaa atataaatct ccgcctgaaa
    12061 caatcacatt ttccatatgt aagtccgtaa tagaaaatat ttcagaaaat gctgctaaaa
    12121 caccatactt aaagtaaatt ttcgctactt catctttatt ggaacttgta taagctacac
    12181 caagttgcca acaataatct gctttaacta agcttttagg aagactgaat gagggtatat
    12241 tactagattt caataaacta gtaagttcta acaagatact gtgtgaatga taacttttag
    12301 gcttgtagta aacagatttc tctttaaacg caattttaac gactgtttgc tttttagagt
    12361 gactgtcacc aagtgaaaag gcaacattgc ttaggggctc actaatatta aagcacgacc
    12421 ttatctcaga caaatctttt aaaaacctat caaatagcaa agagtatgat tccactacca
    12481 atccaacttc tctattgatt tgttttagca aatatggata tctgtcaaaa aaattactta
    12541 tcccattttc ttcccttatc tgctgtatat attgttcata tgcctttgac ttgttttcaa
    12601 tttccttgga aaaatgattt atatctagaa ctagtgtttt cattgaaaga aacattatag
    12661 tttcaaataa ctgattttca aactcactat aaaataactt atgtgtcttt tcccttaaca
    12721 aataaatatt ttcactaata gaagtatcta atatgtcgta atcaaaaatt gagttaaagt
    12781 attcgtaaaa ctgatgttgc tgatattcta actttaattc atttcttttt atcatttttt
    12841 cctaccacta cttaaaaatc ctgcctagac taagtctaaa caggaaattt tagtctgctt
    12901 atccagattg ttttaattaa caacaaacga atactgagtt cggacagtca tcagtaatag
    12961 ttgcaaacca acctgaacct tttttaccac cagctacttc cataagttct ttttcagaaa
    13021 cttcttcgat agcattagtc aaaatatcct ttgaattttt cataaaactc attctccttt
    13081 ctatcagtat gtagtgacta ttttctacac ttttattgta aataatacgt cttcattttc
    13141 aatgagtaaa aagtgcaaaa atgacttttt tcatattttt tagtaagatt tttgagatgt
    13201 cacataagag gtcactttat aacaaatagc cctctgatct aaaaaacaaa actcgttctt
    13261 tacagctatt ttacaatcta atcgcttctc gttataacat caatctctaa tcagaaaatg
    13321 gttactttac ttatttaatc aggtcaggag tttgaatgac agaagtcaaa tatctgaaaa
    13381 aggatgttaa ataaaacttt caaaacccat tttcatcaac taaaaacact tataacccga
    13441 tcttacaact aatggattac catcaacagc aaataatact atgcttgaaa aatgtcaaca
    13501 tcatctactt tttgtgacta taattcagta aacgaacatg acgtgtaaaa atgtattaaa
    13561 aaagtatctc aaaatcattc aatcacttga gtttctgcta cttttttata ccagtaggca
    13621 ctcttcttag gataacgttc ttgagtttca aaatcaacat agaagagacc gtaacgtttt
    13681 tcatagccat ttgaccatga aaagacatcc atcagtgacc acataaagta tcctttaaca
    13741 tttgtaccat cagaaatagc atcagaaata acttctaagt gttttttcac ataatcgata
    13801 cgtccatcat cataaacagt attatctaca aactcatctt tgtaaccaag accattttca
    13861 gtgatataaa ttttcttgta gttaggataa tcggctttga cacgcatgat ttgatcatat
    13921 aagccttgtg ggaagataat ccaatcccag tccgtttttg gaacatcaac gggagctttt
    13981 cttcgaccca cacccttgat ttggtattta gagctgcctt tttccccttt accattatga
    14041 atgatttcag tctcaccatc aaaagcttgc atccaatcac tcatataata gttaatacca
    14101 aggaagtcat tcaaatcttt tgcagcgtct agtgcagcaa aatcttcctc acgaagatca
    14161 agttcaccac catttacctc aaggatatgg ttaacacctt ccattgtttt atctgaatac
    14221 ttacctagat aagttgcatc aagaataaat ttattatgga tgatatcttc cagttcagct
    14281 gctctaacat catcaggatt gttagcgtca aatggatact tagttggaag agcatggaca
    14341 acaccaattt cacctgaata gccactatct ttaaagagtt tgactgcacg agcatgagag
    14401 accatcatgt tatggtgtga ttggaaaact ttagcaagat catattggat acctggaggg
    14461 aatttaccaa ctaagtattg accatcacca ataggcccaa tttcgttaaa tgttgtccaa
    14521 tagttaactt ctgagaattc tttaaaacaa aattctgcat aatttacaaa atgttcaatg
    14581 ttctcacgat tgaggaaatc accatccgag tggagagctt ctggggtatc aaaatggtga
    14641 agtgtaacaa aaggctcaac atgacgctta tgacactctg caaagagatt gtggtagtat
    14701 tcaactcctt tagggttaac ttctcctttt cctgttggaa aaatacgaga ccaggcaata
    14761 gagatacgga tgccgttgac accaaattct tcactaagtt tcaaatcgac tggataacga
    14821 ttgtaaaaat cacttgctgg ttcagcagtg taccaatagt tgtcttctaa gtatttatcc
    14881 caagctactg gtcctttgcc atctgtatgg gtagcacctt cagcctggta agcagctgta
    14941 gcaccaccaa aaataaaatc tttaggtaat gtttttgtca tctcagtttc tccttgaata
    15001 tctttcaaaa ataaagttcc caaaacaatt tttgtgtttg agaactttac gacatttaaa
    15061 ctgttttctt aattttcaaa ctgtgctttt acaaaatcaa gagctccttg accatcacgg
    15121 gtcaatttga tgtattgagc cccttctgtt ttagctaatt taatatcaag tttatcagtt
    15181 tccactttca tatcttcata gttagaagct acttgaggtg caaggataac aagttgatat
    15241 tgtggtaaaa tctcacggtg agcaccataa cttcctgctg ctgcagtgac aggtgcacca
    15301 tattctttag ctgctttatt caaagcattt gctagtagtc cacttgtacc accaccggca
    15361 caaagaacga gaacattagt ttgatcagtg atttttttgg tttctttagc tgctgatttt
    15421 tcaagaatag catcagcttt tttagtatca aagtttgctg ctactttttc tttgagggca
    15481 tctgatgaat tcgtacctgc tgcttcttca gcaagaattt gctcatcata aattttcaag
    15541 aatgggtagt agataatcac atcaacaaca attaacaaag ctgccaaaat gaatgctagc
    15601 acttggaagt ttgtaccaag gataagaccc aatggagctg gtgttgtcca aggtaagttt
    15661 gcagtgaaac tgttcattcc aagtgtgtca atgaagaatt tgaaaatcca tacgttgaca
    15721 atcggtgcca agataaatgg aataaagaaa attgggttca aaacaagtgg agcaccaaac
    15781 aaaatgggtt cgttaacacc aaagaatgtt ggaacaacag atgcacgtcc aatggctttg
    15841 ttacgttttg attttgttaa ccacatgaac atgaatggaa cgacgagagt tgcaccagta
    15901 ccacccatgg taacgatgaa catttgagtc cctgaagtca aaatcttgtc agcatgttca
    15961 ccagcttgaa gtaattgaag gttggtttca gcatttgcgt aagtaatcgc tgcaatggct
    16021 ggttcaacaa tagatggtcc atgaatacca acaaaccaga agaaagcaaa tgcaccgaag
    16081 ataatagtga ttccaacata gccatctgct gcttggaaca atggtgcaag aagtttacca
    16141 attgattctg caacgttaac gcctaaagta gtatgaacaa tcaattcaat cacataaagc
    16201 agtacaactg ataacgtaaa tggaatcaaa tctttaaaaa cttgagatat atttggtgga
    16261 acctcttctg gcatgcgaat ggtaacattg tttttcacac aggttttata gacatttacg
    16321 gtaataaaag ctgcgatgaa ggctgtcaac aaaccttttg ttcccataaa tccagttaag
    16381 aaaccaccgt cttttgctgg attggctgcc ataagtaaaa aacctacaat agcagcgagc
    16441 atggttgaaa taaagttgat ttggtttgtg cttggtaatg atcgattcat tgagtcagtt
    16501 aaagctttgg ctgtcgtacc agccacaaac aaacctaaaa tacccattga gtagttgtat
    16561 ggcgtcatca agagattctc aatatcctta ctccaatgga agccccatgc atttggaaca
    16621 taggcaatca agataaagat acttgaaaac aagataactg gcataccagc gataaaacca
    16681 tcacgaatag cgcgaagata gatatttcga gaaattttct cgaagaaagg tttccctttc
    16741 tcaatctgag caattaatcc attcattatt ttgctcctct cttataaagt tcaatcatgt
    16801 gtttcattaa atcttgtaat aaaatggtcg tcattaaatg atcttgacca tgcattaaag
    16861 tgacactata agctaagtca tctccagctg cttctttttg tagtagactt gtctgagcat
    16921 tgtgagcatc attcaagcag tcactacctg cagcgattaa ttcttctgct ttagcataat
    16981 ctccttcttg cgatgcttta agcgcttcca aaaattttga acgggcatca ccagcatagg
    17041 ctacgatttc aaaacctaaa agagtagttt cttctctatt cattgtagtt tcctccgaaa
    17101 ataatgttac attttttcag tccaaggact tgcagtttta tctagtactt tgtttaattc
    17161 gtcaatattt ttgaaacctt ctgtacgcaa ccattcacga gctgcttgtg gtccttcttc
    17221 gatatagact tttacagatc ctgcccaggt agcacgtcca cataagacac cgttgaattt
    17281 agcacctgat tctgctgcaa acaccaaagt atcttggaac aatttggcag aaacacctgc
    17341 actcaagtaa atatatggta aatcagtaga agcttcttgg tcacggaaag cttgagctgc
    17401 ttcttctttt gtaaagagaa cctcaccatc tgcaaagctt tctacaaatt tcatatttac
    17461 tggaacttcg actttcaaga cgtcaacacc aaagcgttct tctgagaaga ctttcattgc
    17521 ttcattaact ttatgagctt taacttttgc aaactcaggg ctagcattgt cagagatttt
    17581 ctcatcataa gttagaattt ctaagtagaa tggaatatct tctgcacggc attcagaacc
    17641 aatacgttca atgtaagatt ttttctgctc gttaacatct tgatctccat caatatcata
    17701 gtaaagaagg aacttaactg cttctgctcc agcttcttta atacgttttg cagaccaaac
    17761 atctaagcaa tcaggtaagc gactagttgt tgttgcatcg tatcctgttt tctcatatgc
    17821 caacaacaag cctgcttctt ctgaacgaac acgacttgct ggcaagccat attcaggatc
    17881 aagtagaatt gaggatgcaa atggtgttag ttcttcagaa actaaacttt taagctcttc
    17941 aatttgttct actgttggct cttttgtttg atgttgagcc atcatacgtt tgagagctcc
    18001 acgttggtca aaagctaagg cagaaataac accatctaca cttagttttt ccatgctttt
    18061 acgtttgttt tcagttaaag taattgtcat tttttatacc tctttgattt taatagattg
    18121 atataactta tcgtaatttg ccatgttaac atgcccagtt gttttttctt gcgcatttaa
    18181 catccctaag acatttgctt ttgttaataa agctcgatca tcttcatcat tcgctaaacc
    18241 tgaagcaata cctgccactg tagaatctcc tgaacctaca gcgcttacaa ttttaatttt
    18301 aggaatgtca acgttataaa acgtatcctt gtgctttgca aatacaccat cagcaccgag
    18361 agaaacgatt atccattcaa ttccatcaaa taacttatct tgtaagactt cttttaaggc
    18421 atcaaaatct tttgtcattt cttttccgag aagttgagaa agttcttcaa gattaggctt
    18481 gataactgtt ggtttactat caccttttag tactgcttct aaagcatttc cagaacaatc
    18541 tagaacagtc ttcttaccat taagattggc aatcttgatt aacttctgat agtaatcatc
    18601 tggcatacca gcaggcaaac tgcctgagag cgtcactacg tcaacatcat tcagtaaata
    18661 tttaaaatga tgagtaaatc catcaatttc atctacactt aacatcggtc ctttttctaa
    18721 aatctccgtt tgattacctt cgtgtaaaat ggctatacat gttctggtat cacctgaaat
    18781 tttatagaag cgacttaaaa tcgaatcagg aagatgatta atgataaaat caccgctttc
    18841 tccacctata caaccagtag ctttgactgt ttctccgaat tcattaagaa ctcgggaaac
    18901 attcaagcct ttaccaccgg gtgtctttgt aacgtctata actcgattga cagtatcaca
    18961 ttttagctca tccaaagggt aggagacgtc aatagctgga tttaaagtaa ctgttaaaat
    19021 cacaatagct cctttttcta tatatcctta tcataattct ttcaaatatt agtcgtgata
    19081 ttcaccacgg tcccattttt ctagaaattc atcaaagaag tgtgggttgt tttgatcttg
    19141 gctagcatgt tgcaagctat ccattttttc aatccatttt ttattttctt cagttggttt
    19201 gtattccgcg gccaagaaag catcgataat atcattcatc aataaaccac cgatgatttt
    19261 tccaccaaaa ccaataacgt ttgcgtttag ctcttctttt gagtagatag cagatgtcat
    19321 atctctaacg agtgctgcac gaataccggg aactttgttt acagcatttg tgataccaac
    19381 accagtacca cagataacaa cacctaattc tgcttcacca cttgctactg cttcaccaac
    19441 ttttttacca aagattggat agtgtgtgcg aacattatca tatgtaccac aatcaataac
    19501 tttatgacct tgtgatttta ggtaatccac aacagcgact ttttcataag taacaatatg
    19561 gtcacaacct acagcaattt tcatttttat tctccttgtt ttaacctatt tcaatcaatt
    19621 agcacatttt attaagcatg tcgacacgaa cttgatgacg tccaccatca tatttacctt
    19681 cgacaaagcc tttgataatg ttctttgcaa ttcctggtgc actgatttca gaaccaagcg
    19741 tgatgattcg agcattgttg tgtcctcttg tcatgtatgc tgagcgctca tctgatactt
    19801 cagctgccac cattcctttg attttagtag ctaccatgaa agaaccaaca ccatatgcat
    19861 caatgacaat acctaagtta tcttcggatg cattaacttc ttttgcaaca gctaaagttg
    19921 tatctacaaa gtcacgtact tcgttttcac taacatcaac gacttcgtat ttaccttctt
    19981 taaggtaatc tttgataact tctttaagtt cttgacctgc tttgtcagca ccgataataa
    20041 ttgccatttt atttctccta tgatttagaa taagtaaatg tggaaaacct acgtagatag
    20101 ttaattaacg atttgcaaca tcttttgaaa taacgctttc attatttcta tgacctaatc
    20161 atacactcac caaacataaa agtcaacatt ttattgttta tttttataaa aaataaacaa
    20221 aatatgttta ttttttcgtt tttacgttat tatcctaatg tttcttgtgt ttctttttca
    20281 tttcataaat ccctttgaca gccactcgta acctatcata tattacgaaa cccttatctc
    20341 tatttattgt aaacgtttta tttaaaacat tttctatttt gttaattttt gttttttcca
    20401 atgtttatgt ttgttttgtt tgattttttt attgatatta tgttatgata cctttaatag
    20461 ttatacccta agacactgat aggagataag aatgaaaaag aaagagcgtc atgaaaaaat
    20521 tctcgatatc ttaaaagttg acggttttat aaaagtaaaa gatattattg atgaaatgaa
    20581 catctcagat atgaccgcta gacgagatct cgatacattg gcagataaag gattacttat
    20641 caggacccat ggtggtgctc aatatttgga ttattcttca gcaaaggacg acggtcacga
    20701 gaaaacacac actgaaaaga aggtcttaca gactaccgaa aaaaaacaaa ttgcacaaag
    20761 agctaaaaac attattaaag atggcgaaac tgtctttata ggtccaggga caacattaga
    20821 gcatctagct gtcgaattga aaaatagaaa tatcagagtt attacaaata gccttcctgt
    20881 ttttttaatt ttgcacccga gcactactat tgatttgatt ttaattggtg gtgaatgtcg
    20941 tgaaattact ggagcttttg ttggtgctat tgccattaat aatctagaat cattaacttt
    21001 ttcaaaggct tttgttagcg caaatgcagt ttacaataat tctattgcga cgtacagtga
    21061 tctcgaagga gaagttcaaa gggttgcatt gaataatgct gttgagaaaa tccttctagt
    21121 tgatagtacc aagtttgaaa gttatgactt ctataatttc taccaactag atcaagtgga
    21181 cttaattgtg actgataaaa atgtgacaac tgatatcata gaaaagtaca agaaattctc
    21241 aaaaatcata atcgctgaca agtaaaggac ctactcatat taaaaagcac ttcagggttt
    21301 agatatatcc cctgtcaagt aaacagggag catatctgaa agtagtgttt gtgttataaa
    21361 gaagtttctt gctaacttat tttctggttt ttttcagact tatcagtctt gtactgttcc
    21421 tttttctgat gaataacgtg gaaataggca gacagctata tatttcacct ctagaatggt
    21481 tgtcattact gtcatcaaga catgcttgtt ctttatcgta tggagtgaag ctttctttta
    21541 gacatcaaca tacctcttaa gtagattttg gttcgttacc atgtctactt aagagaggtc
    21601 ttcaaagcgc tttaaaacgc tgatataaca gtatattaac gttttgagaa ttgtgaagct
    21661 ttacgagctt ttttaagacc tggtttttgg ttcactccat tatttaaagt caaatccctt
    21721 taaaatcaat gtttctaaaa tgaaaaatca ctaaaaatct tatttataga caaatattta
    21781 aacctaaacg gtatcaaaaa taagtttcgg agcttatcaa ataatgaaaa tctgtctcaa
    21841 ttaccgagtc ttttttattg acttttttgt atatatgata taattaaata aattacataa
    21901 aggggttaca taaaacgact acagtaaaaa aaaatagagc ggttaccttt caagctaata
    21961 aagaattggt aagcgaagca atgacagtat taaacaaaaa aaatttaacc ttatcatctg
    22021 ctttaagatt attcctacaa aatgtcgttg tcacaaacga ggttgactta ttgacggaag
    22081 aggagttaga gaaagaaaaa cttttcaagc aatttcaagc tgaaatcaac aaaaatattg
    22141 aggatgttcg tcaagggaag ttttatacct ctgaagaagt gagggctgaa cttggactat
    22201 aagaaatatc agattatcta tgctcctgat gttttagaga agctaaaaga aattcgtgat
    22261 tatatttctc aaaactattc ctcaacatca ggtcagcgta aaatgaagca aatcattagc
    22321 gacatagaaa aactcgaggt tttcccagaa gttggttttg atgccgatga aaaatatggt
    22381 tcaaaaatca tccattatca cagcactaaa ggttatacct taagtaaaga ttatattgtc
    22441 ctataccata tcgaggggga agaaaatagg gtcgttattg attacttgct tcctactcaa
    22501 agcgactata taaagttatt caaataacac gttaaaagcc ttagcagtct tgctagggct
    22561 tttttggtag attaccaatt aactaggagc aaaatgagtt cgggctgttt aatagatatt
    22621 ccacaaagaa accaaagact acgaagctag gctaatctac cttaaggctt caggaaactt
    22681 ggaggagttc accaagccaa ctcataaaac ttatagcgag atattcgaga aatggtatca
    22741 agcttatcaa gatacggtag agccaaccac ggcttctcgt actcttgatc tgtttcgact
    22801 tcacattttg ccagtcatgg gagaattgcc catta
//
