LOCUS       NZ_LS483425            11889 bp    DNA     circular CON 13-FEB-2024
DEFINITION  Streptococcus pyogenes strain NCTC13737 chromosome 1, complete
            sequence.
ACCESSION   NZ_LS483425
VERSION     NZ_LS483425.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1
  AUTHORS   Doyle,S.
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (08-JUN-2018) WTSI, Pathogen Informatics, Wellcome Trust
            Sanger Institute, CB10 1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/13/2024 01:17:44
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,756
            CDSs (total)                      :: 1,667
            Genes (coding)                    :: 1,613
            CDSs (with protein)               :: 1,613
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 54
            CDSs (without protein)            :: 54
            Pseudo Genes (ambiguous residues) :: 0 of 54
            Pseudo Genes (frameshifted)       :: 32 of 54
            Pseudo Genes (incomplete)         :: 27 of 54
            Pseudo Genes (internal stop)      :: 25 of 54
            Pseudo Genes (multiple problems)  :: 24 of 54
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:29:05
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1417711
            Orig. end                         :: 1429600
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LS483425.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11889
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="5"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11889
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11889
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6889](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6889)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            179..421
                     /locus_tag="DQN36_RS09295"
     CDS             179..421
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285423.1"
                     /locus_tag="DQN36_RS09295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_111704302.1"
                     /transl_table=11
                     /translation="MKQQGHTVMMCLDKTLTIKLSAPLTSNHLVPLSTNEVIIMEPLLH
                     LLPKVVPVLIHLVDKANVSWLTVILQLPILLKTIW"
     gene            943..1212
                     /gene="stcA"
                     /locus_tag="DQN36_RS07080"
                     /old_locus_tag="NCTC13737_01402"
     CDS             943..1212
                     /codon_start=1
                     /gene="stcA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560518.1"
                     /locus_tag="DQN36_RS07080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01402"
                     /product="quorum-sensing system protein StcA"
                     /protein_id="WP_020833327.1"
                     /transl_table=11
                     /translation="MTKKQFYLILAISILCFILAVSPKPPILKHTIERKRTAMTIGHSK
                     QNLHKKEALKHKKNKNKALFLPSGDSAIKSVINMTVRLLLDDQS"
     gene            complement(1560..1958)
                     /locus_tag="DQN36_RS07085"
                     /old_locus_tag="NCTC13737_01403"
     CDS             complement(1560..1958)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635342.1"
                     /locus_tag="DQN36_RS07085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01403"
                     /product="histidine kinase"
                     /protein_id="WP_172453762.1"
                     /transl_table=11
                     /translation="MHRLPNRLIPEEDNNKLSRVAKEVVTEPRLNNPFLLPKKVLSLED
                     DAAILNHLEEDRNVNKLFLEPVAAEAKREINFHPSDQQVTAKVKESSDFHQKQHQTGIT
                     YGDDTLADLTRHLLHSDGVLPSLNDKSA"
     gene            complement(2051..3121)
                     /locus_tag="DQN36_RS07090"
                     /old_locus_tag="NCTC13737_01404"
     CDS             complement(2051..3121)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528351.1"
                     /locus_tag="DQN36_RS07090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01404"
                     /product="hypothetical protein"
                     /protein_id="WP_111704303.1"
                     /transl_table=11
                     /translation="MMMLRDVKVKTSSLLVGCAATLLVSLSSTVAADSVHSSDRRFGVG
                     YKEETTSQFSSDQPSQVVLYRGEANTVRFTYTNQMYLMKDIRIALDGSGKSLTAQTVPG
                     MGHVYEGFQTSARGIFTMSGVPESTVPVANPNVQTKYTRYFKVIDDMHNTMYKGTVFLV
                     QPQAWKYTMKSVDQLPVDDLNHIGVAGIERMTTLIKNAGALLTTGGSGALPDNIKVSIN
                     SKGGQATITYGAGSTDIIPPAVLWKKGSVKEPTEADQSVGTPTPGIPGKFKRDQSLNEH
                     EAMVNVEPLSHVVKDNIKVIDEKSTGRFEPFRPNEDEKEKPASDVKVRPAEVGSWLEPA
                     TALPSVEMSAEDRLKS"
     gene            complement(3372..3773)
                     /locus_tag="DQN36_RS07095"
                     /old_locus_tag="NCTC13737_01405"
     CDS             complement(3372..3773)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017771275.1"
                     /locus_tag="DQN36_RS07095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01405"
                     /product="hypothetical protein"
                     /protein_id="WP_111704304.1"
                     /transl_table=11
                     /translation="MRNILRFLGIVIISAVILFSIGSFYDLPLMKNVQLICWSFILDLF
                     VFVYKQRQTTEVLTWYQVVKQFWLFIKCTILIPTLIAFIIIIGCLTSISEVSIYFYLHL
                     TVVCYTIGMILSLGRLISPNHSIFNKLKK"
     gene            complement(3989..4249)
                     /locus_tag="DQN36_RS07100"
                     /old_locus_tag="NCTC13737_01406"
     CDS             complement(3989..4249)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012560515.1"
                     /locus_tag="DQN36_RS07100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01406"
                     /product="hypothetical protein"
                     /protein_id="WP_111704305.1"
                     /transl_table=11
                     /translation="MKILDIIFNLSDRKMIFLENVEKLGGYVVPFTLIILSVAYNFRHP
                     YPIWAAVLGGISLIVIFIYFILIVYLYLRYRYLVWKKNTRN"
     gene            complement(4299..4472)
                     /locus_tag="DQN36_RS09260"
     CDS             complement(4299..4472)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003073350.1"
                     /locus_tag="DQN36_RS09260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bacteriocin"
                     /protein_id="WP_306460903.1"
                     /transl_table=11
                     /translation="MAIINGGGKDGANIFLTGMAGAAQGVTVCAQTGVFIPWQGYILCG
                     AAGAATNIIWPH"
     gene            complement(4788..4988)
                     /locus_tag="DQN36_RS07115"
                     /old_locus_tag="NCTC13737_01407"
     CDS             complement(4788..4988)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010921972.1"
                     /locus_tag="DQN36_RS07115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01407"
                     /product="class IIb bacteriocin, lactobin A/cerein 7B
                     family"
                     /protein_id="WP_003060803.1"
                     /transl_table=11
                     /translation="MTTMKELTINDMASISGGNAPGDAVIGGLGGLASGLKFCKLPHPV
                     LTGGCVVGFTVGGAYLGYTAN"
     gene            complement(5001..5228)
                     /locus_tag="DQN36_RS07120"
                     /old_locus_tag="NCTC13737_01408"
     CDS             complement(5001..5228)
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015016754.1"
                     /locus_tag="DQN36_RS07120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01408"
                     /product="Blp family class II bacteriocin"
                     /protein_id="WP_002992018.1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 7.1e-17,
                     bitscore: 58.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEIKKLETFHQMTIEKLAKVEGGKNNWQANVSGVIAAGSAGAAIG
                     FPVCGVACGYIGAKTAITLWAGVTGATGGF"
     gene            5541..6227
                     /locus_tag="DQN36_RS07125"
                     /pseudo=""
     CDS             5541..6227
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000191693.1"
                     /locus_tag="DQN36_RS07125"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTQFTTELLNFLAQKQDIDEFFRSSLEIAMNDLLQVELSAFLGYE
                     PYEKEGYNTGNSRNGTYSRQFEKKYGLVNLIIPRDRNGEFSPVLLPSYARREDHLEEMV
                     IKLYQTGVTTREISDIIERMYGHHLFLSGSLVTKRL"
     gene            complement(6447..6629)
                     /locus_tag="DQN36_RS07130"
                     /old_locus_tag="NCTC13737_01411"
     CDS             complement(6447..6629)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002987564.1"
                     /locus_tag="DQN36_RS07130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01411"
                     /product="class IIb bacteriocin, lactobin A/cerein 7B
                     family"
                     /protein_id="WP_002987564.1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 2.8e-07,
                     bitscore: 27.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNFLELQFEELVNISGGKGNIGSAIGGCLGGMLIAAAGGPITGG
                     AAAFVCVASGIAAYQ"
     gene            complement(6644..6889)
                     /locus_tag="DQN36_RS07135"
                     /old_locus_tag="NCTC13737_01412"
     CDS             complement(6644..6889)
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994504.1"
                     /locus_tag="DQN36_RS07135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01412"
                     /product="Blp family class II bacteriocin"
                     /protein_id="WP_002994504.1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1.9e-15,
                     bitscore: 53.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKFAEEIQKEELFHIIGGYSATDCKNHLIGGITSGAIAGGVGAG
                     MATLGVGGVAGAFAGAHVGAIAGGLTCVGGMLFNGK"
     misc_feature    complement(6846..6860)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 20.12"
                     /tool="antismash"
     gene            7286..7540
                     /locus_tag="DQN36_RS09215"
                     /old_locus_tag="NCTC13737_01413"
     CDS             7286..7540
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990779.1"
                     /locus_tag="DQN36_RS09215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01413"
                     /product="hypothetical protein"
                     /protein_id="WP_011106868.1"
                     /transl_table=11
                     /translation="MSGLFYHKSYFFKSEQVYDLLNEIRMRYPHAHIILIGNHINYEEI
                     FKNHYRVFGVIDTTSHKSLRSIRDQIQLYLDELYNSNNG"
     gene            complement(7846..8322)
                     /locus_tag="DQN36_RS07145"
                     /old_locus_tag="NCTC13737_01414"
     CDS             complement(7846..8322)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009880370.1"
                     /locus_tag="DQN36_RS07145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01414"
                     /product="NUDIX hydrolase"
                     /protein_id="WP_093974809.1"
                     /transl_table=11
                     /translation="MPQDYISYIRSKVGHDKIILNFAGGILTNDDGKVLMQLRGDKKTW
                     AIPGGTMELGESSLETCKREFLEETGIEVEAVRLLNVYTHFEEVYPNGDAVQTIVFIYE
                     LTAVSDMAIDNFHNKETLKLQFFSHEEIAELESVSAKHRLMLEEYFSDSFAMGH"
     misc_feature    8279..8295
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 21.42"
                     /tool="antismash"
     gene            complement(8342..9238)
                     /gene="era"
                     /locus_tag="DQN36_RS07150"
                     /old_locus_tag="NCTC13737_01415"
     CDS             complement(8342..9238)
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /codon_start=1
                     /gene="era"
                     /gene_functions="other (smcogs) SMCOG1227: ribosome
                     biogenesis GTP-binding protein YsxC"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003047080.1"
                     /locus_tag="DQN36_RS07150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01415"
                     /product="GTPase Era"
                     /protein_id="WP_002985743.1"
                     /transl_table=11
                     /translation="MFKSGFVAILGRPNVGKSTFLNHVMGQKIAIMSDKAQTTRNKIMG
                     IYTTETEQIVFIDTPGIHKPKTALGDFMVESAYSTLREVETVLFMVPADEKRGKGDDMI
                     IERLKAAKIPVILVINKIDKVHPDQLLEQIDDFRSQMDFKEVVPISALEGNNVPTLIKL
                     LTDNLEEGFQYFPEDQITDHPERFLVSEMVREKVLHLTQQEVPHSVAVVVESMKRDEET
                     DKVHIRATIMVERDSQKGIIIGKQGAMLKKIGKMARRDIELMLGDKVYLETWVKVKKNW
                     RDKKLDLADFGYNEKEY"
     misc_feature    9291..9306
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.57"
                     /tool="antismash"
     gene            complement(9358..9765)
                     /locus_tag="DQN36_RS07155"
                     /old_locus_tag="NCTC13737_01416"
     CDS             complement(9358..9765)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002262772.1"
                     /locus_tag="DQN36_RS07155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01416"
                     /product="diacylglycerol kinase"
                     /protein_id="WP_002985746.1"
                     /transl_table=11
                     /translation="MALHDNNTTKRKWKNRTITSSLEFALTGVFTAFKEERNLRSHLLS
                     ACLACVAGLFFSISAIEWLFLLLAIFLVITLEIVNSAIENVVDLASDYHFSMLAKNAKD
                     MAAGAVLMISGYAVLTGLIIFIPKIWNIFVH"
     gene            complement(9746..10243)
                     /gene="ybeY"
                     /locus_tag="DQN36_RS07160"
                     /old_locus_tag="NCTC13737_01417"
     CDS             complement(9746..10243)
                     /GO_function="GO:0004540 - RNA nuclease activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0042254 - ribosome biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="ybeY"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018380869.1"
                     /locus_tag="DQN36_RS07160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01417"
                     /product="rRNA maturation RNase YbeY"
                     /protein_id="WP_111704306.1"
                     /transl_table=11
                     /translation="MYIEMIDETGQVSQEIMEQTLDLLNFAAQKTGKEEKEMSVTFVTN
                     ERSHELNLEYRDTDCPTDVISLEYKPETPILFSQEDLAADPSLAEMMAEFDAYIGELFI
                     SIDKAREQSQEYGHSFEREMGFLAVHGFLHINGYDHYTLEEEKEMFTLQEEILTAYGLT
                     RQ"
     misc_feature    complement(10257..10271)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 18.45"
                     /tool="antismash"
     gene            complement(10402..10977)
                     /locus_tag="DQN36_RS07165"
                     /old_locus_tag="NCTC13737_01418"
     CDS             complement(10402..10977)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985750.1"
                     /locus_tag="DQN36_RS07165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01418"
                     /product="uracil-DNA glycosylase family protein"
                     /protein_id="WP_009880369.1"
                     /transl_table=11
                     /translation="MDDLTKAIMADEANLSYTERGIFPLYDAPQTARIIIVGQAPGIVA
                     QETKLYWNDRSGIRLRDWLGVDNDTFYHSGLFGIIPMDFYYPGKGKSGDLPPREGFAAK
                     WHPPLRALMPEVELTILVGRYAQDFYLGNKAYKTLTETVRHFEDYLPDYFPLVHPSPRN
                     QLWLAKNPWFEQDLLPILQKRVEAILTK"
     misc_feature    11260..11273
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 21.93"
                     /tool="antismash"
ORIGIN
        1 tggatatcct gattatcgtt ggtggataac ctttcgctta aaaacaatcc acttttggga
       61 aacccttata tttagtttgt aacaggaaaa ctaataaata ttaaaaagag tgttagcgac
      121 ctagcggcag ctttactctt aagtgcgttt gctgccattg acagcaaggt caaggctgat
      181 gaaacagcag gggcataccg ttatgatgtg tctggacaaa acacttacta tcaaactatc
      241 agctccatta accagcaacc acctggtgcc actctcgacg aatgaggtga ttattatgga
      301 acccttactt catttacttc ccaaagtcgt accagtactt atacacttgg tagacaaagc
      361 caacgtatca tggttaacag tgatattaca gttacctata ctcttaaaga caatttggta
      421 gcccttcata aggaatataa aacctttgtc aaaaaaatat tacagataaa ccgatcacca
      481 gtgactacga caaggctaag gttatttata accatttaat caacgaatac acttacgcca
      541 caaaataact tagcaccaat tgcaaaaccg taagcagcat caacaatcat actcctaaag
      601 ctctttatcg tggcaagtgt ggtgtttgtc aagcttatgc cgtcatgttt aaagatatgg
      661 cagaagctgc aggcttatca gcttggtatg tgataaaaaa ggattgaatg agcaccatgc
      721 ttgaaacatc gttaccattc atggtgttaa ttcctacgtt gatgctacct ggaatgattc
      781 agcatacacc acaaggtatt tccttgctgg aaaagacgtg aggaatactg agtaccgttt
      841 agatagccag tacaaccact tggctaatgc tattttaaat accagctacc aaaaaggcta
      901 aactaacaac aactacattt ttcaactaga aaggcctaaa caatgaccaa aaaacagttt
      961 tatcttatct tagctattag catactgtgt tttattcttg ccgtcagccc taaaccacca
     1021 attcttaaac acactattga aaggaaaagg actgcgatga ccataggcca ctcaaaacaa
     1081 aaccttcaca aaaaagaagc ccttaaacac aaaaaaaaca aaaataaggc tctttttctt
     1141 ccaagtgggg acagcgctat caaatctgtt attaacatga cagttagact cctgttagat
     1201 gaccaatctt agctctccta aaatcagtgg acactaccat ttcggtagtg ttctttttta
     1261 agctaatctc atcaccacgc tttcttcaag ctaaaaaact gatcatgaaa gagcaacccc
     1321 atcaccctaa cagcccactt tgcccgcact ttcttaaaaa gttaggagaa aacgatatac
     1381 caattatttt ctgatcccag ctccctatca ttaacaagat gtgtagcacg gacctacata
     1441 caggtaagct agagtcattc tctctatttc ggacaaaaag aggccggtag ttccctgccc
     1501 tcttctttat ttatcttgta acactcctct tcttagcgag acttactagc acataattct
     1561 taagcactct tatcatttag actaggaaga acaccatctg aatgaagcaa atgacgcgtc
     1621 agatctgcca gagtatcatc tccataagta atccctgttt ggtgctgttt ctgatgaaaa
     1681 tcagatgact ccttaacttt agcagtcacc tgctggtcac ttggatgaaa attaatttct
     1741 ctcttggctt cagccgcaac tggctcgagg aacaacttat tgacattacg gtcttcctcc
     1801 aaatgattaa ggatagcagc atcatcttct aacgaaagaa ccttcttggg taacaaaaag
     1861 gggttattta gccttggctc agtaacgact tccttggcta ctcgtgatag tttattattg
     1921 tcttcctcag gtatcaaacg gttaggcaat cgatgcaatt cttccggctg tgaggcgctc
     1981 acagctactt cagaagaaac ctccaagccc tttcctgttt gcttgtctaa agcaaccggc
     2041 aatttattaa ctaacttttt aacctgtcct cagcgctcat ttcaacacta ggaagagctg
     2101 tcgctggttc tagccagcta ccaacttctg ctggtcttac cttaacatcg ctggcaggct
     2161 tctccttctc atcttcatta ggtctaaaag gctcaaaccg ccctgttgat ttttcatcta
     2221 tgacctttat attgtctttt actacatgag acagtggttc gacatttacc atagcttcat
     2281 gctcgttaag gctctggtct cgtttgaatt taccaggaat accaggagtc ggtgttccga
     2341 cagattgatc ggcttcagta ggctctttta cggagccttt tttccataaa actgctggag
     2401 gaataatatc cgtagagcca gccccataag taatcgtggc ctgccccccc tttgagttaa
     2461 tagatacttt aatattgtcc ggtaaggctc cactacctcc tgtggttaaa agggcacccg
     2521 catttttaat gagagttgtc attcgttcaa taccagcaac gccaatatgg ttcaagtcat
     2581 ctactggtaa ctgatcaaca gatttcatgg tgtatttcca agcttgcggt tgaacaagaa
     2641 aaacagttcc tttatacatt gtgttatgca tatcatcaat gactttgaaa taccttgtat
     2701 atttggtttg tacattaggg ttagcaacgg gaacagtgct ttcaggaact cctgacatcg
     2761 taaaaatccc tctagcagaa gtttgaaagc cctcataaac atgacccata ccaggaacag
     2821 tctgagcggt caaagactta ccagaaccat ccaaagcaat gcgaatatct ttcatcagat
     2881 acatctgatt ggtataggta aacctaaccg tgttagcctc acctcgatac aaaaccactt
     2941 gggagggctg atccgaagaa aactgagagg ttgtttcttc cttatagcca actccaaaac
     3001 gtctatcaga cgaatggact gaatctgccg caactgtact actcaaactg actagtaaag
     3061 tagccgcaca accaactaat aaactgctcg ttttaacttt aacatctctt aacatcatca
     3121 tgttcctttc attatttttt atttaggaat tcgtcatact atattttctc atattagtct
     3181 aacaaaaaac tcgtaattct atataaatca tataaaatga cgagctttgg caaagatgag
     3241 tatagcagga ttgaaaacag attgtttctg aaacttcaaa ggtatcttct tgtcacgaac
     3301 tattctttaa ttgaatcggt tacactaaac tagtcccatt atttaaaaac aaactttaaa
     3361 tattattcat ttcacttttt aagtttatta aatatagagt gattaggaga aataagacga
     3421 cctaatgata aaatcattcc tattgtatag caaacaacag taaggtgtaa ataaaagtaa
     3481 attgatacct ctgatatact cgttaaacat cctattatta taataaaagc aattaaggta
     3541 ggaataagaa ttgtacactt aataaataac caaaattgct taacaacttg ataccatgtg
     3601 agcacttctg tcgtttgtct ttgtttgtag acaaaaacga ataaatcaag gataaaactc
     3661 caacagataa gttgtacatt tttcattaat ggtaaatcgt agaaactacc tatgctaaat
     3721 agaatcactg cagaaataat aacaatacct aaaaatctta atatattacg catatcttca
     3781 cctcctctac tctatcggta gcaaatataa ccgaacaaat tgttattcct gttatcagag
     3841 acagttataa cttttttaac caattttcaa tacgcatttt gcttttaact ctttagtctc
     3901 taaagttaaa tatcatacgt actgatattg tataagtaat ccattttccc cttaaatgtg
     3961 attgcatgat agctcagtag aattaatctt aatttctggt attttttttc cataccaagt
     4021 atctataacg caaatataga taaacaataa gtataaaata aataaagatc acaataaggg
     4081 atatacctcc tagtacagca gcccaaatag gataagggtg cctaaagttg taggctacac
     4141 tcaagatgat aagggtaaaa gggacaacgt aacctcccag cttttcaaca ttttctagaa
     4201 atatcatctt tctatcagat aggttaaaaa taatatctaa aattttcata ccactcctct
     4261 actacttata catcagtgat agatagtcat ttatatattt agtgaggcca gataatattt
     4321 gtagcagcac cagctgctcc acacaaaata taaccttgcc aagggataaa tacgcctgtc
     4381 tgagcacaaa ctgtcactcc ctgcgcagca cctgccatcc ctgtcaaaaa gatatttgct
     4441 ccgtcttttc cgcctccatt tatgatagcc agaccatttt tttagcactt ccatattttt
     4501 gaagtctttt tcattttaat ttcactcttt tgtattttaa aaagctaaga gtgatatcta
     4561 aattcattgg cataatcact attttctttt atcgataaaa acaaataatg acgctaccaa
     4621 agctacgata gataacatgt ttaccgattt ttccgaaagg gataattgat tgaaaattaa
     4681 aaacactaaa tatggtatag atttatcaac atttttttat gaatggcatc aacaatgatt
     4741 aaaaacatta tagacgcatt cataataata aaaatcgtat agatcattta atttgctgta
     4801 tatcccaaat atgctccacc aactgtaaat cctacaacac atccacctgt caatactgga
     4861 tgtggcagtt tacaaaattt caatccagaa gctaagcctc caagaccacc aattacagca
     4921 tctcctggag cgtttcctcc acttatacta gccatgtcat taattgttaa ttccttcatt
     4981 gttgtcatcc tttctttcct ctagaatccg cctgtagctc ctgttacacc agcccaaaga
     5041 gtaatagctg ttttagctcc aatataacca caggctacac cgcaaactgg aaaacctata
     5101 gcagctccag cactacctgc agcgataacc ccactgacat ttgcctgcca attattctta
     5161 ccaccctcaa ccttggcaag cttttctata gtcatttggt gaaatgtttc cagtttcttt
     5221 atctccatat cgaataactt cttttcataa ttcttaaatt tgtctcgttg caacctcgac
     5281 tagtacagaa tatcataaag aacagtatca tggtttcaaa atcttaaaag gctgtttttc
     5341 atcatgaaat gtctttttat cctctctaca cttacgctgt gacaatagtt aattaagaag
     5401 tttaaataat accattcatg cttttataaa taccttttaa gatttttgat ggtagtgtaa
     5461 aatatcttgt gtaaacacac aaaaaggaat aaatcctgta tagtagagtt gcgaaactta
     5521 ctagaaagag atttattccc atgactcagt ttaccacaga attacttaac ttcctagcac
     5581 aaaaacaaga tattgatgaa ttttttcgct cctctttaga aatagctatg aatgacctct
     5641 tgcaagttga actatcagct tttcttggtt atgaacctta tgaaaaagaa ggttacaaca
     5701 caggtaatag ccgtaatggg acttattctc gtcagtttga aaaaaagtat ggcttagtca
     5761 atttaatcat cccaagagat cgaaacggcg agttttcacc agttttatta ccatcttatg
     5821 ctagacgaga ggaccacttg gaagagatgg tgatcaaact ctatcagact ggcgttacga
     5881 cacgcgaaat cagtgacatt attgagcgca tgtatggtca ccacttgttt ctgagtggaa
     5941 gcctcgttac aaaaaggtta tgacatcact tgaaacaacg gaaaatctcc taactttcta
     6001 tcaatttcca cattacattt ggtctagtat ttactctaca aacttgattg aatcactcaa
     6061 taaagaaatc aagcgacaaa gcaagaagga gggtggtttt tccaaatgaa gaagccttag
     6121 aacgatgtct tgtaagtatt ttcgaagact ataatattaa gttcggagct cgtattcata
     6181 aaggatccgg agtatgtttt gacacacttg atagcttatt tgactaatat tcaaaaactc
     6241 tactcttgtg tttacacaac attattgaca gtctcaatta atctatatcc ctttaatatt
     6301 attaatttgt aatagtactt agtaagacat aaacaaatat cacaattaaa attactttac
     6361 ttgcattttc tcttacctct ttatccttca aaaaaatttg ggaaagtatt agacaaatta
     6421 aaccgagtat tataactata atcatatcat tgataagctg caattccaga tgctacacat
     6481 acaaatgctg ccgcacctcc agttattgga cctcctgctg cagctataag catcccacct
     6541 aagcaccctc cgatagcaga tccaatattt ccttttccac cagaaatatt tactaattct
     6601 tcaaactgta attctaaaaa attatccatt tttcacctca aaattatttt ccattaaata
     6661 acataccacc aacgcaagtt aatccacccg caatagcacc tacatgtgca cctgcaaacg
     6721 cacctgcaac tcctccaaca cctaaagtag ccatacctgc tccaacacca cctgcaatag
     6781 cacctgaagt aataccacca attaaatgat ttttacaatc tgtagcacta taacctccaa
     6841 taatatggaa caactcttct ttttgtattt cttctgcaaa ttttatcata actttaaaaa
     6901 cctttctaaa atgttatatt catcttgttg caactttgac aaactaaata tagcatatta
     6961 ttataaaaat tttttctatg tcgtgaatgg ttgtataaac atctcaaata aactttttaa
     7021 catatttgag actgtcaata atgttgtgta aacacaagag tagagttttt gaatattagt
     7081 caaataagct atcaagtgtg tcaaaacata ctccgaatcc tttatgaata cgagctccga
     7141 acttaatatt atagtcttcg aaaatactta caagacatcg ttctctttta ggatatatga
     7201 tatctatcta tattaactat tacctcaaga gatactttct aaaaactcaa attattagtg
     7261 ggaaaaactt agattataaa tacaaatgtc aggtttattt tatcataaat catacttttt
     7321 taaatctgag caagtatatg accttctaaa cgaaatacgt atgcgttatc ctcatgctca
     7381 tattattcta atcggaaatc atattaatta cgaggaaata tttaaaaatc attatcgagt
     7441 ttttggtgtt attgacacaa caagtcataa atcattaagg tccattcgag accaaattca
     7501 actttactta gacgaacttt acaattcgaa taatggatag gcacttcatc aattctttta
     7561 ggaaataatt cttgtcaccc cttccaagtc tattgccaca gttaggttca acttgcctaa
     7621 gtcatgcata gctaggtggc aattcgtcat aactctaaaa caaatgtttg atgtctgcta
     7681 gtatcaattg gaaagaaaat cctgttaaca tttaacaaaa ttattcagac ttaatcagaa
     7741 aaattggaag caaaaaaaga gagcataagc tctcgaaaca tcgtctttca aaaatttttt
     7801 taacaagcca atctccaaaa atactccaac tgtcctagag agttcttaat gccccatagc
     7861 aaagctatca ctaaaatatt cctctaacat caggcgatgt ttggctgaga cactctctaa
     7921 ctctgctatc tcctcatgag agaaaaactg taacttgagc gtttccttat tatgaaagtt
     7981 atcaatagcc atatcagaaa cagccgttag ttcatagata aagacaatag tctgaacagc
     8041 atcaccgttg ggataaactt cctcaaaatg agtgtaaaca ttcagtaagc gaacagcttc
     8101 aacctcaatt ccggtttcct ctaagaactc acgtttgcaa gtctctaaag agctctcacc
     8161 cagttccata gtgccaccag gaatagccca ggttttctta tcaccacgca actgcatcag
     8221 caccttgccg tcatcattgg tcaaaatccc accagcaaag ttaagaataa tcttatcatg
     8281 cccaactttg gagcggatat aagaaatgta gtcttgtggc atatgatctc gctttactat
     8341 gttagtattc tttctcatta taaccaaaat cagctaaatc aagcttttta tcccgccagt
     8401 ttttcttgac tttgacccac gtttctaagt agaccttgtc acctaacatg agttcaatat
     8461 cacggcgcgc catttttccg atttttttga gcatggctcc ttgttttcca atgatgatgc
     8521 ctttttggct atcgcgctcc accataatgg ttgcacggat atgcacttta tcagtctctt
     8581 catctcgctt catggattcg acaacaacag ctacggaatg tggaacctct tgttgcgtca
     8641 aatgcagtac cttctcacga accatttctg acacaaggaa acgttctgga tgatcagtaa
     8701 tctgatcttc tggaaaatat tggaaacctt cttcaagatt atcagttaat aacttgatta
     8761 gggttggcac attattacct tctagggcag aaattgggac cacttcttta aaatccattt
     8821 ggctacggaa gtcatcaatc tgttccaaaa gttggtctgg atgaacctta tcaattttgt
     8881 tgataactaa aataacagga atcttagctg cttttagccg ctcgataatc atgtcgtcac
     8941 ccttaccacg cttttcatcg gcaggaacca tgaaaagaac cgtctcaact tcacgtaaag
     9001 tactataagc agattcaacc ataaaatcac caagggcggt ctttggttta tgaatacctg
     9061 gcgtatcaat aaagacaatt tgttctgttt ctgtggtgta aatgcccata attttattac
     9121 gggtggtctg agccttgtca ctcatgatgg caattttttg ccccatgacg tgatttaaaa
     9181 aggtggattt gccaacattt ggacgaccaa gaatggctac aaagcctgat ttaaacatag
     9241 ataattacgg gccttaacgg tagggcttca gatcaaactt gtcactaagc ttaaccgtct
     9301 tgtcctttcc ttattctcct atgccatcat cacataggat agcccattcc tttcttttta
     9361 atgaacgaaa atattccaaa ttttaggaat aaaaataata agtcctgtca agacagcata
     9421 gccagaaatc atcaaaacag cacctgctgc catatcctta gcatttttag ctagcataga
     9481 aaagtgatag tcactagcca aatcaactac attttcaata gcagaattga caatttctaa
     9541 ggtaatgacc aaaaaaatgg ctagaagtaa aaataaccat tcgatggctg aaatgctaaa
     9601 aaataaacca gcaacacaag ctaaacaggc agacaaaagg tgacttctga gattgcgttc
     9661 ttccttaaaa gctgtgaaaa cccctgtcaa ggcaaactcc aagcttgagg taatggttct
     9721 gtttttccat ttccgtttgg tggtattatt gtcgtgtaag gccataagca gtcaaaatct
     9781 cttcctgtaa ggtaaacatc tctttttctt cttcaagggt gtagtgatca tacccattaa
     9841 tatgtaagaa tccatgaaca gctaaaaatc ccatttcacg ctcaaaagag tgcccatatt
     9901 cttgggactg ctcacgcgcc ttgtcaatag aaataaacaa ttcgccaata taagcatcaa
     9961 actctgccat catctctgcc aaactaggat cagcagccaa atcctcttga ctaaataaaa
    10021 taggcgtttc tggcttatat tctagagaaa tcacatctgt tggacaatca gtatctcggt
    10081 attctaagtt gagttcatga cttctttcat tggtcacaaa ggtcacagac atttcttttt
    10141 cttctttgcc cgtcttttga gcagcaaaat tgagcaaatc aagtgtttgc tccataatct
    10201 cttgcgaaac ttgtcccgtt tcgtcaatca tctcgatata cataaggtta attgttaggg
    10261 aagggctgcc cacctcattt ggtatgttgg gcacccatta ttatctgaca gataatttcc
    10321 cttatccttt caatcagcat ttgttattta cccattatac cacaagcccc ttaaaaatgg
    10381 gaatgctagg taaatcaggg cctatttggt tagaattgcc tccacacgtt tttgcaagat
    10441 aggtaataaa tcctgctcaa accaggggtt cttagctaac cacaattggt ttcttggaga
    10501 aggatgaaca agtggaaaat agtctggcaa gtaatcctca aagtgacgga ctgtttcagt
    10561 taaggttttg taagccttgt taccaaggta aaagtcctga gcatagcgac caaccaaaat
    10621 cgtcaattca acttctggca tcaatgctct taatggcggg tgccacttag ccgcaaaacc
    10681 ttctctaggt ggtaagtcac cggattttcc cttaccagga taatagaaat ccatagggat
    10741 aatgccaaac aatcctgagt ggtaaaaggt gtcattgtcc acacctagcc agtctcgtaa
    10801 gcggatgcca ctacgatcat tccagtaaag tttggtttct tgagctacta ttccaggagc
    10861 ttggccaaca ataataatcc tagctgtttg aggagcatca tataaaggaa aaatacctct
    10921 ttcggtatag gagagattag cctcatctgc cataatagct ttggttaaat catccataga
    10981 atcctcctta aaaaggccat attaaacatc atcgtaaagg tcttagtgct cttgaccgat
    11041 cacagggtat tttgtcaagc ctggctggta atcagcttca acgtcactag ccttaggttt
    11101 tagtaagtcc ttcatctcct ctgaggacgt ttcataagcc ttgataatat cagccacaac
    11161 aggatgtcgg acaacatcct tagcagagaa atagacaaaa tcaatctgtt taatgccttg
    11221 taatttctga gtagcatcaa tcaaaccaga cttgacattt cgagggagat caatctgact
    11281 cgtatctcca ttgacaatca ttttagaatt aaaaccaaga cgggtcaaaa acatcttcat
    11341 ttgcatgatg gtcgtgtttt gagcctcatc taagataaca aaagcgtcat ccagagtacg
    11401 accccgcata taagctaacg gagcaatctc aatcacatct cgttccatca ggcgtgtggt
    11461 ttgttccttg cctaaaatgt gataaagggc atcgtaaaca ggtctgaggt aaggatccac
    11521 cttttctttc aaatcgcctg gtaaaaaacc taggctttcg ccagcttcta ccgcaggacg
    11581 cgtcaaaata atacgcttta cctgtcctct tttcagagca gtgactgcaa gcgtaacagc
    11641 taagaaggtt ttccctgtcc ctgcaggtcc tacaccaaaa accacatcat gacgtttgac
    11701 actatcaaca taggtttttt gacctaatgt tttgactcgt attgccttac catagttatc
    11761 tttaatgatt tcttcttcat aaagcgccat aaattggtca atctgatgag attctgccat
    11821 agataaagct gtcaccacat ctgatgtgtt gaccaccatg ccacgaccca ctagaaccag
    11881 tagggcttt
//
