LOCUS       NZ_LS483425            22784 bp    DNA     circular CON 13-FEB-2024
DEFINITION  Streptococcus pyogenes strain NCTC13737 chromosome 1, complete
            sequence.
ACCESSION   NZ_LS483425
VERSION     NZ_LS483425.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1
  AUTHORS   Doyle,S.
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (08-JUN-2018) WTSI, Pathogen Informatics, Wellcome Trust
            Sanger Institute, CB10 1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/13/2024 01:17:44
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,756
            CDSs (total)                      :: 1,667
            Genes (coding)                    :: 1,613
            CDSs (with protein)               :: 1,613
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 54
            CDSs (without protein)            :: 54
            Pseudo Genes (ambiguous residues) :: 0 of 54
            Pseudo Genes (frameshifted)       :: 32 of 54
            Pseudo Genes (incomplete)         :: 27 of 54
            Pseudo Genes (internal stop)      :: 25 of 54
            Pseudo Genes (multiple problems)  :: 24 of 54
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:29:05
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1342623
            Orig. end                         :: 1365407
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LS483425.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22784
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="4"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22784
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22784
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12784](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12784)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    complement(130..148)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 24.33"
                     /tool="antismash"
     gene            complement(672..2222)
                     /gene="ftsY"
                     /locus_tag="DQN36_RS06700"
                     /old_locus_tag="NCTC13737_01324"
     CDS             complement(672..2222)
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_function="GO:0005047 - signal recognition particle
                     binding [Evidence IEA]"
                     /GO_process="GO:0009306 - protein secretion [Evidence IEA]"
                     /codon_start=1
                     /gene="ftsY"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985588.1"
                     /locus_tag="DQN36_RS06700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01324"
                     /product="signal recognition particle-docking protein FtsY"
                     /protein_id="WP_111704288.1"
                     /transl_table=11
                     /translation="MGLFDRLFGKKETPKVAEEKLEENLLTETTQKEELSEKANEQDKI
                     EAVQQEDVSSEGAGSVENGPEAASVNALVEEETGDNSNHPSEDTNEFAADKTDLKVSEL
                     SQSTASEPKDLVDQPVVEQFPTKQAQADASNDSAKEEAVDTSKEQSSSQQVMEDYYRRK
                     AALEKSLQEKAAATVPVMPEEVPQENQASTSAEASQNKATHDTIPETDQEKYKRSLKKT
                     RTGFSARLNSFFANFRRVDEEFFEDLEEMLILSDVGVHVATTLTEELRYEAKLENAKKP
                     DALKRVIVEKLVDIYEKDGRYNEAINYQDGLTVMLFVGVNGVGKTTSIGKLAYRYKQEG
                     KKVMLVAADTFRAGAVAQLVEWGRRVDVPVITGPEKADPASVVFDGMKKAVAKGVDILL
                     IDTAGRLQNKENLMAELEKMGRIINRVLPDAPHETLLALDASTGQNALSQAKEFSKITP
                     LTGLILTKIDGTAKGGVVLAIRQELDIPVKFIGFGEKVDDIGEFHSEDFMKGLLEGIL"
     gene            complement(2222..3046)
                     /locus_tag="DQN36_RS06705"
                     /old_locus_tag="NCTC13737_01325"
     CDS             complement(2222..3046)
                     /EC_number="3.1.3.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1179: hydrolase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990612.1"
                     /locus_tag="DQN36_RS06705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01325"
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="WP_002990612.1"
                     /transl_table=11
                     /translation="MNIRILALDLDGTLYNTEKIVTDANKKALAAAREKGVKVVITTGR
                     PLKAIGNLLEELDLLDHDDYSITFNGGLVQRNTGEVLDKSSLSFDQVCQIQQALEAVGL
                     PTDIISGGDVYSIPSKDGRHSQYHLANPLLTFIEVTSVAELPKDITYNKIVTVTDPDFL
                     DQQIIKLSPSLFEDFEAFKSRDIIFEIMPKGIDKAFGLNLLCQHLGLDARHVMAMGDEA
                     NDFAMLEWAGLGVAMANGVSGAKAVADAVTTLTNDESGVAEAVKTFILEEES"
     gene            complement(3050..3847)
                     /locus_tag="DQN36_RS06710"
                     /old_locus_tag="NCTC13737_01326"
     CDS             complement(3050..3847)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1179: hydrolase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184306.1"
                     /locus_tag="DQN36_RS06710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01326"
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="WP_010922011.1"
                     /transl_table=11
                     /translation="MIKLIATDMDGTFLAEDGTYNQEQLAALLPKLAEKGILFAVSSGR
                     SLLAIDQLFEPFLDQIAVIAENGSVVQYRGEILFADMMTKEQYTEVAKKILANPHYVET
                     GMVFSGQKAAYILKGASEEYIQKTKHYYANVKVINGFEDMENDAIFKVSTNFTGHTVLE
                     GSDWLNQALPYATAVTTGFDSIDIILKEVNKGFGMEHLCQALGIKKAETIAFGDNFNDY
                     QMLEFAGRAIATENARPEIKVISDQVIGHCNDGAVLTYLKGLV"
     misc_feature    3864..3879
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 20.04"
                     /tool="antismash"
     gene            4151..5276
                     /locus_tag="DQN36_RS06715"
                     /pseudo=""
     CDS             4151..5276
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1164: transposase
                     IS3/IS911 family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076612023.1"
                     /locus_tag="DQN36_RS06715"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="IS3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSTVKRYDEEFKQSLVNLYQTGKTQSDLCKDYGVSASALAKWIKQ
                     YSQVKLEDNSVLTAKQIQELQKRNAQLEEENLILKKASAIFMQNLK"
     gene            complement(5390..6127)
                     /locus_tag="DQN36_RS06720"
                     /old_locus_tag="NCTC13737_01329"
     CDS             complement(5390..6127)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000568302.1"
                     /locus_tag="DQN36_RS06720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01329"
                     /product="ABC transporter permease"
                     /protein_id="WP_023612112.1"
                     /transl_table=11
                     /translation="MNDYFKAEWLKTRKGAILAVGIIFLVLSSFIGLANFFLNYEVLIE
                     EQMSRVLWGQLTFYNSQLLFPAMLAIFSGMIILPEFERKTFEMLRANQVSVKKMLLSKF
                     LLALLLITVIQVLLFVIYLVTLKLSQIPFVAKDLLLFLRATVLSVIGSSSVVMIHSYIM
                     AKTKNFSKSVGIAAIGSFCGFIFIMLGGVINQFFPYSQPMIGIRSRALVDMSISEFVIF
                     IVVNALYSFIFFKLTLRTLEKNG"
     gene            complement(6120..6884)
                     /locus_tag="DQN36_RS06725"
                     /old_locus_tag="NCTC13737_01330"
     CDS             complement(6120..6884)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000598724.1"
                     /locus_tag="DQN36_RS06725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01330"
                     /product="ABC transporter permease"
                     /protein_id="WP_085634204.1"
                     /transl_table=11
                     /translation="MIKAIQIELLKSKRTKSFMISFIMMLVAVTWSLLAASRSIDIPKL
                     RTIGLFFNNLQANSIFLPIATCLFVSRIVGNEKEGSTFKLQEANNTNLIIIFTRKLIFT
                     NSVFLLLNIFQVLIVYLNVLRYDIQVPIWTLILQVVGLTMSSFTLITLFLYLSIILEKQ
                     GILLGIGFLSGFFGMITSQTLKWINLIFPFGGSSFLALYRIKILNSSDSLDYIFSWDKS
                     VPLNYTLYLIYCVMIYSVVKYLLKKKKGDNNE"
     gene            complement(6886..7794)
                     /locus_tag="DQN36_RS06730"
                     /old_locus_tag="NCTC13737_01331"
     CDS             complement(6886..7794)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002263495.1"
                     /locus_tag="DQN36_RS06730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01331"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_085613744.1"
                     /transl_table=11
                     /translation="MKNAIELRKLSKVYQDITTVDLEKITVREGEIYGFLGPNGAGKTT
                     TMKMILSLVSPTLGEILINGEDIKGNHAYLSVIGSMIEEPSYYPNLTGYENLLVFQKMV
                     GFDESNIWPTLALVGLAEENNRKKLVKAYSLGMKQRLALAFALVKKPKILLLDEPTNGL
                     DPAGIHEIRELIVKLAKEKGLTVFISSHILSEIEHIADRVGIINHGRLVYEGEIEAIKS
                     NTWIEIGGDFSQNNIVQSLINYGQVEVLGASASHVKFKNIDNDKLADVVTYLIENDYRI
                     FRVVRESENLEDIFLSLTKEV"
     gene            complement(7906..9978)
                     /locus_tag="DQN36_RS06735"
                     /old_locus_tag="NCTC13737_01332"
     CDS             complement(7906..9978)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002268663.1"
                     /locus_tag="DQN36_RS06735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01332"
                     /product="cysteine peptidase family C39 domain-containing
                     protein"
                     /protein_id="WP_023612120.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.1e-38, bitscore:
                     128.7, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIILQNNEEDCLLACYTMLLNDLGHKVPLYEIYDKDTLPADGLN
                     VSYLLSLSDRFGVKINAYHASFDELLKVYGEKKQRMILHWNNDHFVVLEKITSNKTVIV
                     DPAIGRIKYSRDEFLTHYSETMVSVNKRNNFHPQTYKKIFWKYFKQTLQLKPIALFLLS
                     LLFIQVSVLLFSVILRQMLAEDFKFGISLFLLGAVLIFQLLGYFIKNGALDRYNTDFDK
                     YYSKELFQRLLQKPLLYFRNHLSGGVSEKISFKSTLRDNVTLKIIPSCVSLISAIIIFA
                     YLMTISIKLSVILILMIASYSIISTLLYHRQNEYNQTYLQYLIDFNSELQTDLDDIDYI
                     KIMRREKTVFHSWMEQNNQVTKKYSQILKIENLSQLIGTIFNYISLSSIIVIAVYYKDY
                     INLSLPDLLVYQTSISLLISAIEQVKGAVFEVIRLGVYAEKQSDLLKDTSPIVVPSSQS
                     DDYLIKTKNLNFSYGNKPIYSDVNLTISKGEKIAIVGKSGSGKSTLLLMLAGMLRYDGS
                     LEYGIEKFKDNLRVVLQNMTPRKGTVLENLEWTLDDVTPLYQVLNDTTADEVIARLPNK
                     IHSRLLKQGKNLSGGQIQKLLIAKSLLKENSIIFWDEAFSNLDEQSKNKIYDNVLQNNR
                     YSDRTMLIVSHHLDIVNYVDSIIFIDNETGKVIKDTHEHLMETNVNYTNFITSKN"
     gene            complement(10001..12784)
                     /locus_tag="DQN36_RS06740"
                     /old_locus_tag="NCTC13737_01333"
     CDS             complement(10001..12784)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002303301.1"
                     /locus_tag="DQN36_RS06740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01333"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_111704289.1"
                     /sec_met_domain="DUF4135 (E-value: 1e-78, bitscore: 261.8,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.3e-67, bitscore:
                     223.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPKELLYSQFDRFPKVVIENNFPELLNESSELIKDVEDEISDYY
                     RSTLIYLINEKRIEKNLIGDSPESRYEYFNNVLCQNGLIFEEIDRRFPSINQRVMSTIK
                     KRLELINFVKERFTLDFKELRETGYIYSEAQTPKISEVKIKITGDIHNGCGVCILSYEE
                     QKVVFKKKSSNPNVLLHELNIEVGKFLQKDIDFIPDFLDKGEYFWEKFVSSSPLRTEED
                     AKEFYRRMGYLLSYSYILNISDLHFENLISTSFSPKLVDVETVFSVSPYQTVANNESTL
                     EIINNSRNSILSTGLLPVSEAGKVFGGDTSGVLGGTLIGEAKIVINHNRDDIHVEKQKF
                     KTENQDHLPYFIDSKGMKEFLNAEDYVEYIKEGFREVSYFFMNSQDFLKKLYIKHNDIK
                     TRILFRNTRDYSLVRQLLVSPVYCEQSEILFETMANKLSEQNSRSLCLSEKKQLLNMDI
                     PYFYSNIDSCDIKDENMIIWNLESSALSEAINKLEKLSEEIINEQIELIEFSIKTPKAL
                     YSTELQEAYQKFEKVSSSENIIKTGIDTLVDIILENESNSLKDDSTNWLTLKVTDYDAF
                     ELVPMDDSLYEGLSGIAISLSEAYDFLDSGRQRRVKECLKRIFSVLSNSYMKLPNHSFF
                     VGKLGIYSALKRISVVTGQEIQNFIMNYNNLKYTLDVDVLSADFLSSFPNEITALRNSD
                     IKIDNLTQALDKLKELAIVQKDFISWDKLESNNVSLAHGNLGVEIALLYLAGKLESPEA
                     LNLFHKAKMFDKHQKLENGWIDKRNSSTSANWCHGSTGVLVARLAQLKLDDEYSLLSHS
                     ERIELENDMKHAAKQILEIGFDMTNFSLCHGTSGNLLALTYYQSYLTGADSEKLKEILD
                     REYRKLHSFGLENGWMCSFNTKYNVYGLMTGVSGILFSTVKYMKGDDSLDVLIPNF"
     gene            complement(12805..12960)
                     /locus_tag="DQN36_RS06745"
                     /old_locus_tag="NCTC13737_01334"
     CDS             complement(12805..12960)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) leader_d"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002268661.1"
                     /locus_tag="DQN36_RS06745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01334"
                     /product="lacticin 481 family lantibiotic"
                     /protein_id="WP_023612118.1"
                     /sec_met_domain="L_biotic_A (E-value: 1.2e-24, bitscore:
                     82.6, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="leader_d (E-value: 2.7e-05, bitscore:
                     20.9, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEEKMCLGALNALQEFQIEELDNLLGGRGHGVNTISAECRWNSLQ
                     AIFTCC"
     CDS_motif       complement(12880..12960)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEEKMCLGALNALQEFQIEELDNLLGG"
                     /locus_tag="DQN36_RS06745_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(12805..12879)
                     /prepeptide="core"
                     /locus_tag="DQN36_RS06745_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="3.80"
                     /molecular_weight="2594.9"
                     /monoisotopic_mass="2593.2"
                     /core_sequence="RGHGVNTISAECRWNSLQAIFTCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEEKMCLGALNALQEFQIEELDNLLGG"
                     /leader_location="[12879:12960](-)"
                     /alternative_weights="2613.0"
     gene            complement(13160..13315)
                     /locus_tag="DQN36_RS06750"
                     /old_locus_tag="NCTC13737_01335"
     CDS             complement(13160..13315)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) leader_d"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000410306.1"
                     /locus_tag="DQN36_RS06750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01335"
                     /product="lacticin 481 family lantibiotic"
                     /protein_id="WP_085613746.1"
                     /sec_met_domain="L_biotic_A (E-value: 3.5e-27, bitscore:
                     90.7, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="leader_d (E-value: 5.1e-06, bitscore:
                     23.1, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKEHEIINSIQEVSLEELDQIIGAGKNGVFKTISHECHLNTWAF
                     LATCCS"
     CDS_motif       complement(13241..13315)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTKEHEIINSIQEVSLEELDQIIGA"
                     /locus_tag="DQN36_RS06750_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13160..13240)
                     /prepeptide="core"
                     /locus_tag="DQN36_RS06750_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="5.20"
                     /molecular_weight="2778.2"
                     /monoisotopic_mass="2776.3"
                     /core_sequence="GKNGVFKTISHECHLNTWAFLATCCS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTKEHEIINSIQEVSLEELDQIIGA"
                     /leader_location="[13240:13315](-)"
                     /alternative_weights="2796.2"
                     /alternative_weights="2814.2"
     gene            complement(13346..13501)
                     /locus_tag="DQN36_RS06755"
                     /old_locus_tag="NCTC13737_01336"
     CDS             complement(13346..13501)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) leader_d"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000410306.1"
                     /locus_tag="DQN36_RS06755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01336"
                     /product="lacticin 481 family lantibiotic"
                     /protein_id="WP_023612114.1"
                     /sec_met_domain="L_biotic_A (E-value: 9.9e-28, bitscore:
                     92.5, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="leader_d (E-value: 5.1e-06, bitscore:
                     23.1, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKNNEVINSIQEVSLEELDQIIGAGKNGVFKTISHECHLNTWAF
                     LATCCS"
     CDS_motif       complement(13427..13501)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEKNNEVINSIQEVSLEELDQIIGA"
                     /locus_tag="DQN36_RS06755_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13346..13426)
                     /prepeptide="core"
                     /locus_tag="DQN36_RS06755_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="5.20"
                     /molecular_weight="2778.2"
                     /monoisotopic_mass="2776.3"
                     /core_sequence="GKNGVFKTISHECHLNTWAFLATCCS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEKNNEVINSIQEVSLEELDQIIGA"
                     /leader_location="[13426:13501](-)"
                     /alternative_weights="2796.2"
                     /alternative_weights="2814.2"
     gene            13699..14397
                     /locus_tag="DQN36_RS06760"
                     /old_locus_tag="NCTC13737_01337"
     CDS             13699..14397
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002294154.1"
                     /locus_tag="DQN36_RS06760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01337"
                     /product="response regulator transcription factor"
                     /protein_id="WP_085613747.1"
                     /transl_table=11
                     /translation="MNFESQLLNKRILIVDDDVALSKSIKEVLISRDFKNISCAYSISE
                     GIDIFSVSKIDLIILDVMLPDGEGHLLAKYIRKYSDVPILFLTAKNNPDDEIRGLESGG
                     DDYVTKPFLPKSLTYRIIALLRRAYKDESELIELTNCTIDLNNASVEKNGQHLSLTPTE
                     IQILRKLFSNKNYIASTESICDTVWGLESLGYEKSLMVHIRNIREKIEITPSKPNHLIT
                     VKGLGYKLVI"
     gene            14415..15776
                     /locus_tag="DQN36_RS06765"
                     /old_locus_tag="NCTC13737_01338"
     CDS             14415..15776
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677788.1"
                     /locus_tag="DQN36_RS06765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01338"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_109821250.1"
                     /transl_table=11
                     /translation="MNIFKKNILKFILSFFFIIIIDVILLITATNYIRSQQSASTIIET
                     VSSEITLSSNGKYNVSSKAKQLIDDKKLWIMIIDKDSGKEKFNINKPQIIENQFDFADA
                     IRFSRFYLKDYPVFTQIKDNDIYIIAFPKDSIIRYSSNYFELNRVQIFPILILSIIFAN
                     CLFCLFLYIYSVTFLNRNIKPIINAITKLPNGINTQVKSVRELDKLTLAINSANQQLRE
                     NEEFKENWISGIAHDIKTPLSVIVSNTSLAIEKTNDDEFLKHLKPTLVESHYIQNLLND
                     LNIFARLTNGNLKLNHEIVDIIPFFKEIIIQIINQEIWEDFNFEFIPDSKLLGKKMYIE
                     KALISRVVHNLIYNSVLHNHSGCDIKIILEYLPEDCFSITIRDNGIGTSPERLKNINKI
                     EEFNFDMSGVRRSGMGLKISKQIIDLHDGNMIITSTQGQYFQTVITLPIESLNT"
     gene            complement(15992..16507)
                     /locus_tag="DQN36_RS06770"
                     /old_locus_tag="NCTC13737_01339"
     CDS             complement(15992..16507)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF022534.4"
                     /locus_tag="DQN36_RS06770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01339"
                     /product="helical hairpin domain-containing protein"
                     /protein_id="WP_136022160.1"
                     /transl_table=11
                     /translation="MSFKTDCNTQSFVYFYSIHPLPYRKRVTLETLKEKVEKINLLMEI
                     HTPNQTFLETKDQLVQEIATLDMKIEEIQEKIATLNKMAEVFINLESDNKEGKRLARYN
                     LTKTNIPLTIKVDQVEREIEQLQISLTERLDEYEGKVSELEEFVQMLNTLELPLTDRDH
                     LDRNRLAF"
     gene            16527..17654
                     /locus_tag="DQN36_RS06775"
                     /old_locus_tag="NCTC13737_01340"
                     /pseudo=""
     CDS             16527..17654
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076612023.1"
                     /locus_tag="DQN36_RS06775"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01340"
                     /product="IS3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSTVKRYR"
     CDS             complement(17801..17884)
                     /gene="allorf_1360424_1360507"
                     /locus_tag="allorf_1360424_1360507"
                     /protein_id="allorf_1360424_1360507"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MKLETEYFCLSIPLNEQLYRKVIGCLE"
     CDS_motif       complement(17858..17884)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKLETEYFC"
                     /locus_tag="allorf_1360424_1360507_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(17801..17857)
                     /prepeptide="core"
                     /locus_tag="allorf_1360424_1360507_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.00"
                     /molecular_weight="2070.4"
                     /monoisotopic_mass="2069.1"
                     /core_sequence="LSIPLNEQLYRKVIGCLE"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKLETEYFC"
                     /leader_location="[17857:17884](-)"
     gene            complement(18027..18443)
                     /locus_tag="DQN36_RS06780"
                     /old_locus_tag="NCTC13737_01341"
     CDS             complement(18027..18443)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017516.1"
                     /locus_tag="DQN36_RS06780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01341"
                     /product="hypothetical protein"
                     /protein_id="WP_027968806.1"
                     /transl_table=11
                     /translation="MNYKIFIRTKSGDIFDIADGGRIDDMVSKFNKVNVLGVCMGIGTT
                     VLSQEIEYEIEDRIMILVEKIDVKIYKNCLELANKLSGYHCSVFEFPYKKIKKFFKHEL
                     YSRHHYIIVRLDGSMEYRFSSVALKNKIKSILDS"
     gene            complement(18472..18987)
                     /locus_tag="DQN36_RS06785"
                     /old_locus_tag="NCTC13737_01342"
     CDS             complement(18472..18987)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DQN36_RS06785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="NCTC13737_01342"
                     /product="hypothetical protein"
                     /protein_id="WP_227868937.1"
                     /transl_table=11
                     /translation="MSRCIANLPQQIPVKWIQEGVLFRDRIPTYKGYRRQFNQILLGAW
                     GIESAYVDAEIIVATWRGLQRFKGIKVEFIQLSNKNIFDVLEKDLSKKLRFEDISIEAI
                     LGKYLCNNDIEIIKYLYEKDKINMELLISLISKISNKLVKQEFIKVLVLYEYVKKLFTS
                     RLHLLFII"
     gene            complement(19163..20182)
                     /locus_tag="DQN36_RS06790"
                     /old_locus_tag="NCTC13737_01343"
     CDS             complement(19163..20182)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528392.1"
                     /locus_tag="DQN36_RS06790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01343"
                     /product="S66 peptidase family protein"
                     /protein_id="WP_093974798.1"
                     /transl_table=11
                     /translation="MFGKQGIRCARKGDERNIKIIVNRVNSERNIKSIGICSPSYPGTF
                     HYQKRYKRGVEFLQNKGFTIVEGNLTGKEGYRGEISGGVQDRAEELNQLIPRVDVIMTS
                     IGGYNSNSVLKYIDYDLFKQKSPIFIGYSDTTALALALYKKTGCITYLSQSVISNFGEF
                     EPFNELNYFYFDFMLQSKCETLMVQIPDVWTDEWINWETYERTKKTNKNEWIIFNKGEF
                     NGTLIGGNLDTIVGIIGTEYMPKITEDTILLLEDVYTDLGRLYRNFTTLALHGIFDKIG
                     GLIISKFETIGENSDVINDIINEFVGHRKIPILLNFDCGHTHPSCLMPIGGKITLSLS"
     gene            complement(20107..21354)
                     /locus_tag="DQN36_RS06795"
                     /old_locus_tag="NCTC13737_01344"
     CDS             complement(20107..21354)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285438.1"
                     /locus_tag="DQN36_RS06795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01344"
                     /product="acetyl-CoA carboxylase biotin carboxylase subunit
                     family protein"
                     /protein_id="WP_011285438.1"
                     /sec_met_domain="ATP-grasp_3 (E-value: 1.8e-08, bitscore:
                     31.2, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 3.1e-09,
                     bitscore: 33.2, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKNILIVGGGPEITICYDLINNSTEYNFFSVSEIPTMYPELFVE
                     TIETSFRNFGKTIEQIKELKYSIDAVACWDEALTHIADDISKELGLNPISSLDSQSFRF
                     KDRMRMVCEAGGLKMPKYKIINQFSDTNKIINWKYPLIVKPTSFLASIGVKKVYNFSEL
                     QQAVSQMLNVKFPVYIASGVYELGELYNLEPRVLVEEFIDGEEYSLESVVRNGIYTPLG
                     ITKKIVDEKLFMDEIGHIFPSNLNKEEKSRVYSWAEKLHQILQLNHITTHTEFRIGRNG
                     DIILIEIGARIGGDCIPNLMKNSFIVKGFDFYNTYLKARLGLQEELNTDTNKFSGIVFF
                     RLNPENYGKIFNGVSYDAPKTSLIFEEKIYKKEGTVLPNPINWSNERVGYVCLENKEYA
                     VLEKEMKEILKSLSIE"
     gene            complement(21368..22264)
                     /locus_tag="DQN36_RS06800"
                     /old_locus_tag="NCTC13737_01345"
     CDS             complement(21368..22264)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF005053.0"
                     /locus_tag="DQN36_RS06800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01345"
                     /product="asparagine synthetase A"
                     /protein_id="WP_085613751.1"
                     /transl_table=11
                     /translation="MTFFKNEGISTVHLPITTSSITSPMGLGSDSLPVKISLFDVDTYL
                     ADSMQFHLEYILRLFPKSGVHYLMPTFRGEAVDHRHLSQFYHSECEIEGDLHYVMNLVD
                     RYIKFLVSEILRECRDSIFAITKDVSHLESFIDRKIPIITFEEACTILENEIDSLEYND
                     EHHFYVLTDVGEKKLMEHFEGVVWVKNYPCKSVPFYQRFSTDHLFAYNADLLLGIGETV
                     GCGERCETYEEVVENMNYLQVDASEYSWYLEMKKTRPMKSSGFGLGVERLIAWILKCDD
                     VRKVQLISRENGIDYLP"
     gene            complement(22216..22554)
                     /locus_tag="DQN36_RS06805"
                     /old_locus_tag="NCTC13737_01346"
     CDS             complement(22216..22554)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285437.1"
                     /locus_tag="DQN36_RS06805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01346"
                     /product="Fic family protein"
                     /protein_id="WP_023078733.1"
                     /transl_table=11
                     /translation="MKPPFTVTNTMLNKVVEISKIIGNLELQVQKDLKLRKENRIQSIH
                     SSLAIEQNSLTVEQITAIIDGKRVLGNPREIREVKNAYEAYEEILTLTPYDESHFLKMK
                     EFQQYIYR"
ORIGIN
        1 caaccctttc ttgatattcg cattctcaaa attccctctc taacctttgg cctgattccc
       61 ttttttgtct tccagctgat taatttaggc ataaattttc taacgccaaa ctttattgtc
      121 atggaaaaga ttgctaatag ttctcaagct ggtatggtgt tactacctgg taccttactc
      181 ggagctctac tagcacctgc ttttggtaaa ctttatgatc aaaaaggagc aagactttcg
      241 ctttatttag gaaatgcctt atttagttta tcattgatta ttatgacact tcaaacaaga
      301 cattttatgc ttttaccatt cactctttta tatattttat tcacgtttgg gcgtaacatg
      361 ggctttaata atagcttagc cacggctatt cgagaattgc ctgccgagaa aaatgccgat
      421 gccacggcca tttttcagat gatgcagcaa tttgctggcg ctctaggaac tgctatggca
      481 tcactgatag caaatagtca accagaattc acaagcggtg tccagtctgt ctaccttctc
      541 tttactattt ttgctctact tgattttatc tttttctttg ctatgtttta ccatttaggg
      601 aaaaaaggat tagcctaaga tgacatacta aaaaccagtc tcgttcaata aaacgagact
      661 ggtttttgct gttataagat accttccaaa aggcctttca taaagtcttc tgagtggaat
      721 tctccaatat catccacttt ttcaccaaat ccgataaact tgactggaat gtctaattct
      781 tgacggatgg ctaggactac accacctttg gccgtgccat caattttcgt taaaatcaaa
      841 cctgttaatg gtgttatttt tgaaaattcc ttggcttggc taagcgcatt ttgtcctgtt
      901 gacgcatcta aggccaaaag cgtttcatga ggggcatctg gtagcacgcg attaatgata
      961 cgacccattt tttccagctc tgccatgaga ttttctttgt tttgcaggcg accagccgtg
     1021 tcaatcagga gaatatctac accttttgcc acagcttttt tcatcccgtc aaaaacaaca
     1081 gacgctggat cagccttttc agggccagta atgactggca catctactcg gcgtccccat
     1141 tcgactagct gagccacagc ccctgctcgg aaggtatctg ctgccaccaa catgactttt
     1201 ttaccttctt gtttgtaacg gtaagccagc ttcccgattg aagtcgtttt accaaccccg
     1261 ttaacaccta caaaaagcat aaccgtcaag ccatcttgat aattaatggc ttcattataa
     1321 cgcccatctt tttcatagat atctaccaat ttttccacaa tcacacgttt caaggcatct
     1381 ggttttttcg cattttccag tttggcttca taacgcaact cctctgtcaa agttgtcgcc
     1441 acatgtacac cgacatctga taagatcagc atttcttcca agtcttcaaa gaattcttca
     1501 tccactcgcc tgaaattggc aaagaaactg ttcagacgag ctgagaagcc agtccgcgtt
     1561 tttttcaagc tacgcttgta tttttcttga tctgtctcag gaatggtatc gtgggttgcc
     1621 ttgttttgag aagcttctgc tgaggtagag gcctgatttt cttgtggaac ttcttctggc
     1681 atcactggaa ccgttgccgc tgctttttct tgaaggcttt tttcaagtgc agccttacga
     1741 cgatagtagt cttccataac ctgttggcta ctggattgct cttttgaagt gtctactgct
     1801 tcttccttcg ccgaatcatt tgaggcatca gcttgagctt gttttgttgg aaactgttcc
     1861 acaactggct ggtcaacaag gtcttttggt tctgatgccg tagattgact aagttcactt
     1921 accttaaggt ctgttttgtc ggcagcaaac tcattggtat cttctgatgg atgattacta
     1981 ttgtcacctg tttcttcctc aaccagtgcg tttactgaag ctgcttcggg accattttcc
     2041 accgaacctg cgccctctga agaaacgtcc tcttgttgaa ccgcctcaat cttgtcttgc
     2101 tcattggctt tttcagaaag ctcttctttc tgagttgttt ctgtcaaaag attttcttct
     2161 aacttttcct cagctacctt cggggtttct tttttcccaa ataaacgatc aaataatccc
     2221 attaactctc ctcttctaaa ataaatgtct tcacagcttc tgcaactcca gactcatcat
     2281 tggtcaaggt ggtcacggca tcggcaacgg ctttagctcc tgaaacacca ttagccatag
     2341 ctactccaag tcctgcccat tctaacatcg caaagtcgtt agcttcgtct cccatagcca
     2401 tgacatgtct agcgtcaagg ccaaggtgct ggcaaagcaa gtttaatcca aaagctttat
     2461 caatgccttt tggcatgatt tcaaaaataa tatctcgtga tttaaaggct tcaaaatcct
     2521 caaataagct tggggatagc tttataatct gctgatccaa aaagtctgga tcggtgactg
     2581 tcacaatttt gttataggta atgtcttttg gtagttccgc tacagatgtc acctcaataa
     2641 aggtcaacag tgggttagct agatggtact gcgaatgcct accgtcctta cttggaatgc
     2701 tatacacatc cccaccactg ataatatctg ttggtaagcc aaccgcctct aaagcttgct
     2761 gaatctggca gacctggtca aaactgagag aactcttatc caaaacctcc cctgtatttc
     2821 gctgaaccaa acccccatta aaggtaatac tgtagtcatc gtggtcaagc aagtccaact
     2881 cttctagcaa gttaccgatg gcctttagag ggcgacctgt ggtaataacc accttaaccc
     2941 ctttttctct agccgctgct aaggcttttt tattggcatc tgtgacaatt ttttcagtgt
     3001 tgtagagggt accgtctaaa tcaagcgcca aaattctaat attcatgagt tacactagtc
     3061 cttttaaata cgttagtact gctccgtcat tacagtggcc aatgacttgg tctgaaatca
     3121 ctttgatttc aggtcttgca ttttccgtag caatagccct accagcaaac tccaacatct
     3181 ggtaatcatt aaaattatcc ccaaaagcaa tcgtttctgc tttcttaatg cccaaggctt
     3241 gacaaagatg ctccatacca aagcccttat tcacctcttt taagataata tcaatggaat
     3301 caaagccggt ggtcactgca gtggcataag ggagggcttg attcaaccaa tcgcttcctt
     3361 ctaagacggt atggcctgtg aagttggtag aaactttaaa aatggcgtca ttctccatat
     3421 cttcaaaacc attaataacc ttaacattag catagtaatg ttttgttttt tgaatgtact
     3481 cttctgatgc gccttttaaa atataggctg ccttttgccc agaaaaaacc atacctgttt
     3541 ctacatagtg aggattggct aaaatctttt ttgcaacttc ggtatactgc tctttggtca
     3601 tcatatctgc aaatagaatc tcaccacggt attgaaccac ggaaccattt tctgcaataa
     3661 cagcaatctg atccaaaaag ggctcaaaga gctgatcaat ggctaagagc gagcggccac
     3721 tcgaaaccgc aaataaaatg cctttttcgg ctaactttgg caagagcgca gctagttgct
     3781 cttgattata agtaccatct tcagctagga aggtaccatc catatctgtt gctattagtt
     3841 ttatcataca atgtctcctt tttttactct aggggggtgc aaacgccatt tagggtgtgc
     3901 actttttaac gatttaaata agccccatca tttctgcatt ctgttcaatt tttcttatta
     3961 tatcataaaa agcagctttc attccattcg taaaaaacag ccagattata tttcgataac
     4021 ctgaccgttt ttgaagtgaa ctgctacttt tttattttta taaatgacca ctggatgtat
     4081 actataaaag tagacaaaac tttgtgtgtt acaatctgtt ttaaaagaca caaaaacgaa
     4141 aggacaacct atgtcaacag ttaaacgcta cgatgaagaa ttcaaacaat cccttgtcaa
     4201 cctttatcaa actggaaaaa ctcagtctga tctctgtaaa gactatgggg tatccgcttc
     4261 tgcgcttgca aaatggatca aacagtattc tcaagtcaaa ctcgaagata attctgtact
     4321 tactgccaag caaatacaag agctacaaaa acgtaatgca cagcttgaag aggagaacct
     4381 tatcctaaaa aaagcaagtg ccatattcat gcaaaactta aagtaagact cctcgctgtt
     4441 tatcggttac gctttgaaca cgccacaaca accttgtatc gtgttttacg tgtcaatcgc
     4501 tccacttact ataaatttct aaaacataag ccctcaaaaa gagaattgga taatcaaatt
     4561 tatagaaaac aaatacttga gatttatacc aaagcgaaca aaagacttgg tgtgaagtct
     4621 atcaaggtca ttcttcaaag agactatgac acaaaaatct ctgaaggaag aatttaccgt
     4681 cttatgaaga atatggcgct ccctaaaatg gctaccgtta agccaaaaac agctcttaaa
     4741 aggactcaaa aaactcccct caaaacttac tcaaccagaa atttaatcct gacaaaccta
     4801 atcaagtatg gtctactgac ttcacctata tttctattgg atataagaaa tatgtctatc
     4861 tctgcgcaat acttgatctc tattctagaa aatgtattgc ttggaaattg agtcatcgta
     4921 tggatgcaaa gttagcatgt gacactctag aattagctct taataaaaga aagattgaag
     4981 gaacacttct ctttcattcc gaccaagggt cacaatttaa ggccaggaaa ttgagaaaaa
     5041 taattgatga caacactatc atgcattctt tttctaaacc tggatatcct tatgataatg
     5101 ccgtaactga agcatttttc aagtatttaa agcatagaca aatcaaccga aaaaagtatc
     5161 aaaatatcaa acaggttcaa ttagactgct ttgaatacat tgagaatttt tataacaatt
     5221 acaacccaca tacggctaat ctaggactaa cccctaatca gaaagaagaa aattagttta
     5281 acgtaataaa ataacacggt tttctgtcta cttatttgac attagtccac atgctctcac
     5341 cttttccttc tataaattta gttacttctg taatgtataa aaatccactt tatccattct
     5401 tctctaaagt tcgtaatgtc aatttgaaaa aaataaaact atatagagca ttaacaacta
     5461 taaatattac gaactccgaa atgctcatat ctactaacgc tctactacgt atacctatca
     5521 ttggctggga ataagggaaa aattgattaa tgacacctcc caacataata aatatgaatc
     5581 cacaaaatga acctatagct gcaatcccga ctgatttaga aaaatttttt gttttagcca
     5641 tgatataact atgaatcatt acaacagagc tagaaccaat aacagatagc acagttgctc
     5701 ttaaaaataa aagtaaatct tttgctacaa acggaatctg gctcaatttc agtgttacaa
     5761 gatatataac aaataataat acttgtataa ctgttataag tagcaaagct aacaagaact
     5821 tactaagaag catcttttta acagatactt gatttgcacg taacatttca aatgtttttc
     5881 gctcaaattc aggtagaata atcatgcctg agaatattgc taacatagct gggaaaagca
     5941 actgactatt atagaaagtt aactgtcccc agagtactct actcatttgt tcctcaatga
     6001 gtacctcata attcaaaaag aaatttgcca aaccaatgaa actagataga acaagaaata
     6061 taatcccaac tgctaaaata gctcctttgc gagtttttag ccactccgct ttgaaataat
     6121 cattcattat tgtccccttt cttctttttc agtaaatact taactacgct atagatcatt
     6181 acgcagtaaa taaggtataa agtataattt aaaggcacgc ttttgtccca agaaaaaata
     6241 taatctaaac tatcactgga atttaaaatc tttattctat atagtgctaa aaaactcgat
     6301 cctccaaacg gaaaaataag gttaatccac tttaaagtct gggaggtaat cataccgaaa
     6361 aaacctgata aaaatccaat tcctaaaaga atcccttgtt tttctaaaat tattgataaa
     6421 taaagaaaga gagtgattaa agtaaaactg gacatcgtta aacctactac ttgtaaaatc
     6481 agagtccaaa ttggaacttg gatatcatat cttagtacat ttagataaac aatcaagact
     6541 tggaaaatat tcaaaagtag aaagacagaa tttgtgaaaa tcaatttgcg agtaaatatt
     6601 ataattagat ttgtattatt tgcttcttga agtttaaatg tactaccttc tttttcatta
     6661 ccaacaatac gtgaaacaaa taggcaagtt gcaataggta aaaaaataga attagcttgt
     6721 aaattattaa agaacaatcc gatagtccgt aatttaggaa tatcaatact tcttgaggct
     6781 gctaacaatg accacgtcac tgctactaac atcataatga aagaaatcat aaaagatttc
     6841 gtacgcttac tttttaataa ttcaatctgt attgctttta tcatttcaaa cctccttagt
     6901 taaagagagg aaaatgtctt ctaaattctc gctttcccta acaactcgga aaatccgata
     6961 gtcattttca attaaataag tcactacatc tgctaatttg tcattatcaa tatttttaaa
     7021 cttaacatga cttgctgaag cacctagcac ttcaacctgt ccgtaattaa ttaaactttg
     7081 aacaatatta ttttgcgaga aatccccgcc aatctcaatc caagtatttg attttattgc
     7141 ttcaatttcc ccttcataaa ccagtctccc atgatttata atgcctactc ggtcagctat
     7201 atgctcaatt tcggataaaa tatgacttga gataaatact gttagccctt tctccttagc
     7261 taattttaca attaactcgc gaatttcatg aattccagcc ggatcaagtc cattagtagg
     7321 ttcatctaat aacaagattt ttggtttttt aaccagagca aaagccaagg ctaaccgttg
     7381 cttcatgcct aaagagtagg ctttcacaag tttttttcgg ttattttcct ctgctaaacc
     7441 aaccaatgcc aaagtcggcc agatattact ttcatcaaaa cctaccattt tttgaaagac
     7501 tagtagattc tcgtaacctg ttaaatttgg ataataggag ggttcctcaa tcattgaacc
     7561 gattacactc aaataagcgt ggttcccctt tatatcttca ccatttataa gaatttctcc
     7621 tagtgttgga gaaactagtg acaaaatcat tttcattgtt gttgtttttc ctgcaccatt
     7681 cggtccaaga aaaccgtaaa tctcgccttc acgaaccgta atcttttcta aatctaccgt
     7741 agtaatatcc tgatagacct tagaaagttt tcttaattca atagcatttt tcatgttaat
     7801 aaccccataa taagaccctt caatgagtct cttcctttcc ttctattaca acattattgt
     7861 atctaagcaa cttaaagata acattaagaa aagagaaaca ttctcttaat ttttggaagt
     7921 aatgaaattt gtatagttaa catttgtttc cataagatgt tcatgagtat ctttaataac
     7981 cttaccagtt tcattatcaa taaaaataat agaatcaaca taattgacaa tatctaaatg
     8041 atgactaacg attaacatag ttctgtctga atatctattg ttttgtaaaa cattatcgta
     8101 aattttgttc ttactttgtt catctagatt actgaaagcc tcgtcccaaa aaataattga
     8161 attttctttt aaaagtgatt ttgctatgag taacttctgg atttgtccac ctgataaatt
     8221 ttttccttgt tttaagagtc tagagtgaat cttatttggt aatcgtgcta taacttcatc
     8281 agctgttgta tcattcaata cttggtaaag tggagttaca tcatctaaag tccactctaa
     8341 gttttctaag acagtcccct ttctaggtgt catattttga agaacaactc ttagattgtc
     8401 tttgaatttt tcgatgccat attcaagaga tccatcatag cgtagcatac ctgctaacat
     8461 taatagtaaa gttgacttcc cgctaccaga tttacctaca atggcaatct tttctccttt
     8521 actgattgtt aaattcacat cactatagat tggtttatta ccataagaaa agttcaaatt
     8581 tttagttttg attaaataat cgtctgactg tgaactaggt acaacgatag gtgaagtatc
     8641 ttttaataaa tcactttgtt tttctgcata tacacccaat cgaattactt caaatactgc
     8701 tccttttact tgttcaattg ctgatatcaa taaagaaata ctagtttgat aaactaatag
     8761 atcaggaagg gataaattaa tataatcctt ataatatact gcgataacaa ttattgagga
     8821 tagactaatg tagttaaaaa tagttccaat aagttgtgaa agattttcaa ttttaagaat
     8881 ctgcgaatac ttcttagtga cttgattatt ttgctccatc caggaatgga aaacagtttt
     8941 ctctcttctc attattttta tatagtcaat gtcatcaaga tctgtttgta actctgagtt
     9001 aaaatcaatt aagtactgta aatatgtctg attatactcg ttttgcctat gatacaatag
     9061 agtagagatt atactatatg aagcaatcat caagattaat atcaccgaca acttaataga
     9121 tatagtcatc agatatgcaa agataataat agctgaaatc aaacttacac atgatggaat
     9181 aatttttaaa gtaacattgt ccctaagtgt tgatttaaaa ctaatttttt cagatactcc
     9241 cccacttaga tgatttctaa aataaagtaa aggtttttgt aataatcttt gaaacaactc
     9301 tttactgtaa tatttatcaa agtctgtatt atatctatct aatgcaccat tctttataaa
     9361 ataacctaat aattgaaaaa ttaatactgc acctaaaagg aataagctga taccaaactt
     9421 gaaatcttca gctaacattt gtcttaaaat gactgagaac agtaaaacac taacttgaat
     9481 aaacaggagt gacaacaaga ataatgcaat cggttttaat tgtaaggtct gtttgaaata
     9541 cttccaaaag attttcttat atgtttgggg gtgaaaatta tttcttttgt taactgacac
     9601 catagtttcc gagtagtgag ttaaaaattc atcacggcta tacttaatac gaccaatggc
     9661 tgggtcaact ataactgttt tatttgacgt aattttttca agaaccacaa aatgatcatt
     9721 attccaatga agaatcattc tttgcttctt ttctccgtat acttttagta attcatcaaa
     9781 agaggcatga taagcattta ttttcacccc aaatctgtca cttagtgaca aaagatatga
     9841 gacatttaga ccatctgcag gcaatgtatc tttatcataa atttcatata atggaacttt
     9901 atgtcctaaa tcattaagta acattgtata acaagctaag agacaatcct cctcattgtt
     9961 ttgcaaaata atattcatat ctcatattcc tttctatctc ttagaaattg ggaatcaaca
    10021 catctaggga atcatcaccc ttcatgtact ttactgtaga aaataatatt cctgacacac
    10081 ctgtcattaa cccataaaca ttatattttg tattaaaact acacatccag ccgttttcca
    10141 ggccaaaaga atgcagtttt ctatactctc tatccaaaat ttcttttaac ttctctgaat
    10201 cagctcctgt taaatatgat tggtagtaag taagtgccag caaatttcca ctggttccat
    10261 ggcaaagtga aaagtttgtc atatcaaaac caatttcaag aatctgttta gcagcatgct
    10321 tcatatcatt ctctaattct atccgttcag aatgagaaag aaggctatat tcatcatcta
    10381 gttttaactg tgctaacctt gcaactaata ctcctgttga accatgacac cagttggcac
    10441 tagtcgagga atttcttttg tctatccagc cgttttccaa tttttgatgt ttatcaaaca
    10501 tttttgcttt atgaaataaa tttagtgcct caggactttc taactttcca gctaaataaa
    10561 gtaacgctat ttcaactcct aaattaccat gtgcaagact aacattattc gactctaact
    10621 tatcccaact aataaaatcc ttttgaacaa ttgccaactc tttaagtttg tctagtgcct
    10681 gagtaagatt atctatctta atatccgaat ttctcaaagc agtgatttca ttaggaaaac
    10741 ttgatagaaa atcagcactt aaaacatcta catccaatgt atatttgaga ttattataat
    10801 tcatgataaa attttgaatc tcttgtcctg taacaacact aattcgtttt aaagctgagt
    10861 aaattcccag cttccccaca aaaaaagaat gatttggtaa tttcatatag gaattagata
    10921 atacagaaaa aattcgtttt agacattctt taacccttct ttgtcttcct gagtctagaa
    10981 aatcataagc ctctgataaa gaaattgcta ttccagacaa accttcataa agagagtcat
    11041 ccatcggaac taactcaaaa gcatcataat ctgtaacttt caaggtgagc cagtttgtac
    11101 tatcgtcttt tagagagttg ctttcatttt ccaaaataat atcaactaga gtatcaatac
    11161 cagtttttat tatattttca ctgctactaa ccttctcaaa tttttgatat gcctcttgaa
    11221 gttccgtact atataaagct ttaggagttt tgatagaaaa ctcaattaat tcaatttgct
    11281 catttatgat ttcttcactc aatttttcta atttattgat tgcttcgctt aaagcagaac
    11341 tttcaaggtt ccaaataatc atgttttcat cctttatatc acaactatca atatttgagt
    11401 aaaaataagg gatatccata tttaaaagct gtttcttttc tgatagacat aaactacgac
    11461 tattttgttc agacaattta ttggccattg tttcaaataa aatctcggat tgctcacaat
    11521 aaacaggaga aactagcaat tggcgcacta agctataatc tcttgtattt ctgaacaaaa
    11581 ttctagtctt tatatcatta tgcttaatat aaagcttctt taaaaaatct tgtgaattca
    11641 tgaaaaagta gctgacttca cggaaccctt ctttgatata ttcaacataa tcttcagcat
    11701 taagaaattc tttcattccc ttcgaatcaa taaagtaagg caaatgatcc tggttttctg
    11761 ttttaaactt ttgtttttca acatgaatat catctcggtt atgattgatg acgatttttg
    11821 cctctccaat taaggtgcct cctagaacac cactagtatc tcctccaaaa actttaccag
    11881 cttcagaaac aggaagcaaa cctgttgata atatcgaatt tctactatta ttaattatct
    11941 ccaatgttga ctcgttattt gcaacagttt gataggggct aactgaaaaa actgtctcaa
    12001 catcaactaa cttaggagaa aagcttgtag aaatcagatt ttcaaaatgc aaatcagaga
    12061 tattcaatat gtaagaatat gataataagt aacccatcct acgataaaat tcctttgcat
    12121 cctcctcggt tcttaacgga gaacttgata caaatttttc ccaaaaatac tctcctttat
    12181 ctaaaaaatc agggataaag tctatatctt tctgtaagaa tttaccaact tctatattca
    12241 gttcatgcaa gagaacattg ggatttgatg attttttctt aaaaactact ttttgttctt
    12301 cataactcaa aatgcagact ccacaaccat tgtgaatatc tccagttatt ttgattttga
    12361 cttcactaat ttttggagtc tgagcttcac tatagatata gcctgtctct ctcaactctt
    12421 tgaaatctaa agtaaatctt tcctttacaa aattaattaa ttccaaacgt ttcttgatag
    12481 tactcattac acgctgatta atagaaggga aacgtctatc aatttcttca aaaattaagc
    12541 cattctgaca tagtacatta ttaaagtatt catagcgtga ctctggagaa tctccaatta
    12601 ggtttttctc aattcttttt tcatttatta ggtaaataag agtggaacga taataatcag
    12661 aaatttcatc ttcaacatcc ttaatcagct cactactttc atttagcaat tctgggaaat
    12721 tattttcaat aactactttt gggaatctat caaattggct atataacagt tcttttggat
    12781 tcatattctt tactcctaaa catattaaca acaagtaaaa attgcctgta aactattcca
    12841 acgacattca gctgaaattg tattgacacc atgccctctt cctcccaaaa ggttatccaa
    12901 ttcctcaatc tgaaattctt gtaacgcatt caaagcacct aggcacattt tttcttccat
    12961 aattctttac ctcatttata tgacatcgag tagaactcga aatttgtttt ctttatacat
    13021 tgattttaaa tttgttacat aaagacaata ttaaggaaaa ctaaagttaa attaaatttt
    13081 ctacctatgt caatgcaaat aaaaaaagag gtccccctct ttttttatgt aacatcaaag
    13141 acacctgaac agtagagttt tatgaacaac aagtagcaag gaatgcccat gtattcaaat
    13201 gacactcatg agaaattgtc ttaaatacac cgtttttccc agcaccgata atttggtcca
    13261 actcctcaag actaacttct tgaatagagt taataatttc atgttctttg gtcataacga
    13321 ttttctcctt atattttatc taatattatg agcaacaagt agcaaggaat gcccatgtat
    13381 tcaaatgaca ctcatgagaa attgttttaa acacaccatt ttttccagca ccgataattt
    13441 gatcgagttc ttcaagacta acttcttgaa tagagttgat tacttcatta tttttttcca
    13501 ttttctatac ctcatttaac tttcttcaga aggataggtg ccttcctctt tgttacaacc
    13561 ttattttaag atgataactt taagacagaa taaagaaaac ataaatttaa ttttaagatt
    13621 atacaacaca agtcctactt attctcttat atctataatc tttatggtat aattttatta
    13681 cactttagga ggtattgtat gaattttgag tctcaattat tgaataaacg catattgatt
    13741 gtcgacgatg atgtcgcact tagcaaatca attaaagagg tacttatcag tcgggatttc
    13801 aagaatatca gctgtgctta tagtataagc gaaggaattg atatcttctc agtttctaaa
    13861 attgatctca ttattttaga tgttatgcta ccagatggag aagggcactt acttgcaaaa
    13921 tacattagga aatattcaga tgtgccaatt ctctttttaa cagccaaaaa caatcctgat
    13981 gatgaaattc gaggacttga atccggaggg gatgattatg ttacgaagcc atttcttccc
    14041 aaatctttaa catatcgtat tattgcactg ttgagaaggg cttataaaga tgaatcggaa
    14101 ctaattgagc taacaaattg taccatagac ttaaacaatg caagtgttga aaaaaatggt
    14161 caacatttgt cactcactcc aacagaaata caaatcctac gaaaattatt ttcaaataaa
    14221 aattatattg catcaactga atcgatttgt gataccgttt ggggacttga gagccttggc
    14281 tacgaaaaat cacttatggt acatattcgt aatatcagag aaaaaatcga gataactcca
    14341 tctaagccaa atcatcttat tactgtaaaa gggcttggtt ataaactagt tatataaact
    14401 ataaggaata tagcatgaat attttcaaga aaaatatact aaaatttatc ctatcatttt
    14461 tctttattat aataattgac gtcatactgt taataactgc taccaattat atccgaagtc
    14521 agcagtctgc atctactata atcgaaactg tctcatctga aatcactcta tcttctaatg
    14581 gtaaatataa tgttagctct aaagctaaac aactcattga tgataaaaag ttatggataa
    14641 tgattattga caaagatagt ggaaaagaaa aatttaatat taataaacct cagattatag
    14701 aaaatcaatt cgattttgca gatgctatac gattttctag attttaccta aaagactatc
    14761 ctgtatttac gcaaataaaa gataatgata tttacatcat tgcttttcca aaagacagta
    14821 taatacgtta tagtagtaat tatttcgaac taaatagagt tcaaattttt ccaatcctta
    14881 ttttgtctat catatttgca aactgtttgt tctgcctatt tctttacatt tattctgtta
    14941 cttttttaaa tcgtaacatt aaacctatca ttaacgcaat tactaaatta ccaaatggaa
    15001 ttaatactca ggtcaaatct gtacgagaat tagataaatt aacacttgct attaactcag
    15061 caaatcagca acttcgtgaa aacgaagaat tcaaggagaa ttggatttct ggaatagcac
    15121 atgatataaa gacaccactt tcagtaattg tatctaacac ttccttagcc attgaaaaaa
    15181 caaatgatga cgaattcctt aaacatttga aacccacctt agttgaaagt cactacattc
    15241 aaaatctcct aaacgattta aatatatttg ctcgattaac aaacggaaac ttaaaactaa
    15301 accatgagat tgttgatata atccctttct tcaaagaaat aatcattcag attatcaatc
    15361 aagaaatttg ggaagacttc aattttgaat tcattcctga ttctaaacta ttaggtaaga
    15421 aaatgtatat tgaaaaagct ctcatttcta gagttgttca taacctaatt tataattcag
    15481 tacttcataa tcattctggt tgcgacatta aaatcatttt agaatatcta cctgaagatt
    15541 gtttttcgat tactattcgt gataatggta taggaacttc tcctgaaaga ctaaaaaata
    15601 tcaataagat tgaagaattt aattttgata tgtcaggcgt tcgaaggagt ggtatgggat
    15661 tgaaaatttc taaacaaatt attgatttac atgatggaaa catgataatt acaagtacac
    15721 aagggcagta cttccaaaca gtaattaccc tccctattga atcactaaac acttaacaaa
    15781 atttttgata gagcagagat taaaatccga aacataagta aaaaataatg actttagctt
    15841 tctgttattc agaatattta ttttttaggc tctttcttca cgattgcaaa tattattatc
    15901 ggagataata tcaactatga aaaaattttt aaaaatcatt atttagtatt tggtgtgata
    15961 gacactactg caaataaatc actaagatct attaaaaagc aagtctattc ctatctagat
    16021 gatctctatc agtaagagga agttcaagag tattaagcat ttgaacaaat tcctcaagtt
    16081 cactaacctt tccctcgtat tcatctagac gttctgttaa agaaatttgt aactgttcta
    16141 tttctcgctc tacttggtca actttaatag ttaatggaat attcgtctta gtcaggttat
    16201 acctagctag ccttttaccc tctttattat cactttctag attgataaac acttccgcca
    16261 tcttgtttaa ggtggcgatt ttttcttgga tttcctctat cttcatgtct agtgtggcta
    16321 tttcttggac cagctggtcc ttggtttcaa gaaaggtttg gttaggagta tgaatttcca
    16381 ttagtagatt tatcttttca accttctctt tcaatgtttc aagtgttact cgttttcgat
    16441 atggaagtgg atgtatacta taaaagtaga caaaactttg tgtgttacaa tctgttttaa
    16501 aagacacaaa aacgaaagga caacctatgt caacagttaa acgctacaga tgaagaattt
    16561 aaacaatccc ttgtcaacct ttatcaaact ggaaaaactc agtctgaact ctgtaaagac
    16621 tatggggtat ccgcttctgc gcttgcaaaa tggatcaaac agtattctca agtcaaactc
    16681 gaagataatt ctgtacttac tgccaagcaa atacaagagc tacaaaaacg taatgcgcag
    16741 cttgaagagg agaactttat cctaaaaaaa gcaagtgcca tattcatgca aaacttaaag
    16801 taagactcct cgctgtctat cggttacgct ttgaacacgc cacaacaacc ttgtatcgtg
    16861 ttttacgtgt caatcgctcc acttactata aatttctaaa acataagccc tccaaaagag
    16921 aattggataa gcaaatttat agaaaacaaa tacttgagat ttataccaaa gagaacaaaa
    16981 gacttggtgt gaagtctatc aaggtcattc ttcaaagaga ctacgacaca aaaatctctg
    17041 aaggaagaat ttaccgtctg atgaagaata tggcgctccc taaaatggct accgttaagc
    17101 caaaaacagc tcttagaagg actcaaaaaa cgtatcctca aaacttactc aaccagaaat
    17161 ttaatcctga caaaccaaat caagtatggt ctactgactt cacctatatt tctattggat
    17221 ataagaaata tgtctatctc tgcgcaatac ttgatctcta ttctagaaaa tgtattgctt
    17281 ggaaactgag tcatcatatg gatgcaaagt tagcatgtga cactctagaa ttaactctta
    17341 ataaaagaaa gattgaagga acacttctct ttcattccga ccaagggtca caatttaagg
    17401 ccagggaatt gagaaaaata attgatgaca acactatcat gcattctttt tctaaacctg
    17461 gatatcctta tgataatgcc gtaactgaag catttttcaa gtatttaaag catagacaaa
    17521 tcaaccgaaa aaagtatcaa aatatcaaac aggttcaatt agactgcttt gaatacattg
    17581 agaattttta taacaattac aacccacata cggctaatct aggactaacc cctaatcaga
    17641 aagaagaaaa ttagtttaac gtaataaaat aacacggttt tctgtctact tatttgacat
    17701 tagtccaaaa tgtacatcct aatggtgtcg ttttttttat ttcactagac attcgttcta
    17761 gtttaggata taagaaggtc tcaaattttt ttcatgatgt ttattccaaa catccaatca
    17821 cctttctata taactgttca tttagtggta tagacaaaca gaaatactcc gtttctagtt
    17881 tcatagaaga cggagtattt tttagtagaa acgtctggat tgatagatag ttggtatata
    17941 gctcatccct actaggcttt cattatagac tatggtaggt ttcgttgaca acaatatgtg
    18001 attattattc taaatgacag tatacatcaa ctatcaagta tgcttttaat tttatttttt
    18061 aaagctacag atgaaaatct gtattccata cttccatcta atcgaacaat aatataatga
    18121 tgtctcgaat ataattcatg tttaaaaaac tttttgattt ttttataagg aaactcaaaa
    18181 acagaacaat gatacccact taatttattt gctaattcaa gacaattctt atagattttc
    18241 acatctattt tttcaactaa tatcattatt ctatcttcaa tttcatactc aatctcttgt
    18301 gataaaacag tggttcctat tcccatgcaa actcctaata cgtttacttt attaaattta
    18361 gaaaccatat catcaattct accaccatca gcaatatcaa atatgtcacc tgacttagtt
    18421 cgtatgaaga ttttatagtt catacttgaa taatgtcctg ttccatataa attagataat
    18481 gaaaagtaaa tgcaatctgc tggtaaaaag tttttttaca tactcgtaca agactaaaac
    18541 ttttataaat tcctgtttca ccagtttgtt acttattttt gaaataagac taattaagag
    18601 ttccatattt attttgtctt tttcataaag atattttatg atttctatgt cattattaca
    18661 caaatattta cccagtattg cttcaattga aatatcttca aatcttaact ttttagataa
    18721 atctttctcc aaaacatcaa atatattttt gttagacagt tgaataaatt ctactttaat
    18781 tcctttaaat cgttgcaagc ctcgccaagt tgcaactatt atttctgcat ccacataagc
    18841 tgattctatt ccccatgcac ctaataatat ttgattaaat tgtcttctat aacctttata
    18901 tgtaggaatt ctatctctaa ataacactcc ctcttgaatc cactttacag gtatttgttg
    18961 tggtaagtta gctatacaac gcgacatact aagtgccaaa tctgattgga gggcgtatac
    19021 tgactctcct tttactctat gaacttcaaa tatttttgta taatgaacat cggttgcatc
    19081 taattatttt ttctacttct tcctcaaaaa catcatagaa acccgttaat ttactttctc
    19141 tattgttcat ataccacctc ttttagctta aactcaacgt aattttacca ccaataggca
    19201 ttaaacagct aggatgagta tgaccacaat caaaattcaa taaaatagga atctttctat
    19261 gccctacaaa ttcattaatg atatcattaa taacatcgct attttcccct attgtttcaa
    19321 attttgaaat aataagtcct cctattttat caaaaatacc atgtaaggca agcgttgtga
    19381 aattcctata tagtcttcct agatccgtat atacatcttc taacaagagt atggtatcct
    19441 ctgttatttt tggcatatac tcagttccta ttattcctac aatggtatcg agatttcctc
    19501 cgatcaaagt accattaaat tcacctttgt taaaaataat ccactcattt ttatttgttt
    19561 ttttggttct ttcataggtt tcccaattta tccactcatc cgtccaaaca tctggtattt
    19621 gtaccattaa ggtttcgcac ttactctgaa gcatgaagtc aaaatagaaa taatttaatt
    19681 cattaaacgg ttcaaactct ccaaaattag agataacgct ctgagacagg taagttatac
    19741 atccagtctt tttatataag gctaaagcaa gagctgttgt gtcagaatat ccaataaaga
    19801 taggagattt ctgtttaaat agatcgtagt ctatatactt taatacagaa ttagaattgt
    19861 agccacctat ggaagtcatg atgacatcca cacgcggaat aagttgattt aattcttcag
    19921 ctctgtcttg aactcctcct gaaatttccc ctctataacc ttcttttcct gttaaatttc
    19981 cctctactat agtaaatcct ttattttgta aaaattctac tcctctctta tatcgtttct
    20041 gataatgaaa tgtccccgga taggagggtg aacaaatacc tatagatttg atgtttcttt
    20101 cactatttac tctattgaca atgattttaa tatttctttc atctcctttt ctagcacagc
    20161 gtattccttg ttttccaaac aaacatatcc tactctctca ttactccaat taatcggatt
    20221 tggcaataca gttccttcct ttttatatat cttttcttca aatattagtg aagttttagg
    20281 tgcatcgtaa ctcactccat taaatatttt tccgtaattc tctggattga gtctgaaaaa
    20341 tacaattcct gaaaacttat tagtgtctgt atttaactct tcttgtaaac ctagtctagc
    20401 ttttaaataa gtattataaa aatcaaatcc cttgactata aagctgtttt tcattaagtt
    20461 tggaatacaa tctccaccga ttcttgctcc aatttctatt aaaataatat ctccatttct
    20521 tccaattcta aattctgtat gagtcgtaat atgatttaat tgcaaaattt gatgtaattt
    20581 ttctgcccaa gaatatactc tacttttttc ttctttgttt aaatttgaag ggaaaatatg
    20641 gcctatttca tccataaata atttttcatc cactattttt ttagttatcc ctagaggtgt
    20701 atagattcca tttcttacca cgctctctaa gctatattct tctccatcaa taaactcttc
    20761 caccaaaact ctaggttcta aattatataa ttcccccaat tcatataccc ctgaagctat
    20821 gtaaaccgga aattttacat taagcatttg agaaactgct tgttgtaatt ctgaaaaatt
    20881 ataaactttt ttcactccta tacttgctaa aaaagaggtt ggtttcacta ttaatggata
    20941 tttccaattg attattttat ttgtatctga aaattgattg ataattttat atttgggcat
    21001 ttttagtcca ccagcttcac ataccattct cattcgatct ttaaacctga atgattgaga
    21061 atctagcgat gaaatagggt tcaatcctaa ttcttttgaa atatcatcag ctatatgcgt
    21121 taaagcttca tcccaacaag caacagcatc aatagaatat ttgagctctt taatttgttc
    21181 aatcgtcttt ccaaaatttc taaagctggt ttcaattgtt tctacaaaca actctggata
    21241 catcgtagga atttctgata ctgaaaagaa attatactcc gtactattgt taattaaatc
    21301 ataacatata gttatctctg gacctccacc tacaattaaa atattctttt tcatttttct
    21361 tcctccttta tggtaaataa tcaatcccat tttctctact gattaattga acttttcgaa
    21421 catcatcgca cttcaatatc cacgctatta aacgctctac tcctaaacca aatcctgaag
    21481 atttcatagg tcttgttttt ttcatttcta aataccaact atattcagaa gcatctactt
    21541 gtaaataatt catattttct acaacttctt catatgtttc gcatctttct ccacaaccta
    21601 cagtttcgcc tattcctaac aacaaatctg cattataggc aaatagatga tctgttgaga
    21661 acctttgata aaaagggaca cttttacagg gataattttt tacccaaact actccctcaa
    21721 aatgttccat taatttcttt tccccaacat ctgttaacac ataaaaatga tgttcatcat
    21781 tatattccaa tgaatctatt tcattttcca atatagtaca agcctcttca aacgtaataa
    21841 ttggtatctt tcgatcaata aaactttcca aatgacttac atcttttgtt atagcaaaaa
    21901 tactatctcg acactctcta agaatttcac taaccagaaa cttaatatat ctatccacta
    21961 aattcatcac atagtgtaaa tctccctcta tctcacactc actatgataa aattgcgata
    22021 aatgtcgatg atctactgct tctcctctaa aagtaggcat taagtaatga actcctgact
    22081 ttggaaaaag tctaagtata tactctaagt gaaactgcat cgaatctgca agataggtat
    22141 caacatcaaa taaggaaatt tttacaggta gcgaatcact ccccaacccc ataggacttg
    22201 tgattgacga tgttgttatc ggtaaatgta ctgttgaaat tccttcattt ttaaaaaatg
    22261 tgattcatca tagggagtta gcgttaaaat ttcttcataa gcttcataag cgttttttac
    22321 ttctcttatc tcacgggggt tccctaacac tcttttccca tcaataatgg ctgttatttg
    22381 ttctactgtt aaagaatttt gttcaatagc gagtgatgag tgaatagact gaatacgatt
    22441 ttcttttctt aattttaaat ctttctgtac ttgtaattct aaattaccaa taattttaga
    22501 aatctctact accttattta acatggtatt cgtaactgta aaaggtggtt tcatcatttt
    22561 ctccttacaa tcttttttct tatttatacc ataaaaataa atttatcgct cgttcttcaa
    22621 gcgataaaac aagcgataaa ctattacaat ttattttaaa ttctttaacg attactaact
    22681 ttttaacgtt attattttca aatactctac ataaaattac cctagagtat taaaattccc
    22741 actcaaactc ctagtccctt tgtttcaagc tatttagaac tttt
//
