LOCUS       NZ_LS483425            23767 bp    DNA     circular CON 13-FEB-2024
DEFINITION  Streptococcus pyogenes strain NCTC13737 chromosome 1, complete
            sequence.
ACCESSION   NZ_LS483425
VERSION     NZ_LS483425.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1
  AUTHORS   Doyle,S.
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (08-JUN-2018) WTSI, Pathogen Informatics, Wellcome Trust
            Sanger Institute, CB10 1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/13/2024 01:17:44
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,756
            CDSs (total)                      :: 1,667
            Genes (coding)                    :: 1,613
            CDSs (with protein)               :: 1,613
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 54
            CDSs (without protein)            :: 54
            Pseudo Genes (ambiguous residues) :: 0 of 54
            Pseudo Genes (frameshifted)       :: 32 of 54
            Pseudo Genes (incomplete)         :: 27 of 54
            Pseudo Genes (internal stop)      :: 25 of 54
            Pseudo Genes (multiple problems)  :: 24 of 54
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:29:05
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1232084
            Orig. end                         :: 1255851
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LS483425.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23767
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="3"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..23767
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23767
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13767](-)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13767)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     misc_feature    complement(131..142)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.03"
                     /tool="antismash"
     misc_feature    154..168
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.38"
                     /tool="antismash"
     gene            complement(1396..1896)
                     /locus_tag="DQN36_RS06215"
     CDS             complement(1396..1896)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985256.1"
                     /locus_tag="DQN36_RS06215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="QueT transporter family protein"
                     /protein_id="WP_111704260.1"
                     /transl_table=11
                     /translation="MTKLTVHDYVHIGLVAALYVVLTITPPLNAISYGMYQFRISEMMN
                     FLAFYHRKYIIAVTLGCMIANFYSFGLIDVFVGGGSTLIFVTLGVILFSKYQKDYLFNG
                     IFNKAFVYFSFFFATSMFAVAIELYFFGAPFLLTWFTTALGELVSLLIGSLIIDKLSQR
                     VSF"
     regulatory      complement(1894..2009)
                     /bound_moiety="preQ1"
                     /db_xref="RFAM:RF01054"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF01054"
                     /inference="COORDINATES: profile:INFERNAL:1.1.4"
                     /note="PreQ1 riboswitch class II; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            complement(2174..4906)
                     /locus_tag="DQN36_RS06220"
                     /old_locus_tag="NCTC13737_01231"
     CDS             complement(2174..4906)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985259.1"
                     /locus_tag="DQN36_RS06220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01231"
                     /product="SpnA family nuclease"
                     /protein_id="WP_111704261.1"
                     /transl_table=11
                     /translation="MINKKCIISVSLLTLAITLTSVEEVTSRQNLTYANEIVTQRPKRE
                     SVISDKSNFPVISPYLASVDFGERKTPLPTPDKGVKVTTEQSIAQVRKGPEERTYTVTG
                     KIMSVINGWGGYGFYIQDSEGIGLYVYPQKDLGYSKGDIVQLTGTLTRFKGDLQLQQVT
                     AHKKLELSFPTSVKEAVISELETTTPSTLVKLSHVTVGELSTDQYNNTSFLVRDDSGKS
                     IVVHIDHRTGVKGADVVTKISQGDLINLTAILSIVDSQLQLRPFSLEQLEVVKKVTSSN
                     SDASSRNIVKIGEIQGASHTSPLLKKAVTVEQVVVTYLDDSTHFYVQDLNGDGDLATSD
                     GIRVFAKNAKVQVGDVLTISGEVEEFFGRGYEERKQTDLTITQIVAKAVTKTGTAQVPS
                     PLVLGKDRIAPANIIDNDGLRVFDPEEDAIDYWESMEGMLVAVDDAKILGPMKNKEIYV
                     LPGSSTRPLNNSGGVLLPANSYNTDVIPVLFKKGKQIIKAGDYYKGRLVGPVSYSYGNY
                     KVFVDDSKNMPSLMDGHLKPEKTNLQKDLSKLSIASYNIENFSANPSSTKDEKVKRIAE
                     SFIHDLNAPDIIGLIEVQDNNGPTDDGTTDATQSAQRLIDAIKKLGGPTYRYVDIAPEN
                     NVDGGQPGGNIRTGFLYQPERVSLSDKPKGGARDALTWVNGELNLSVGRIDPTNAAWKD
                     VRKSLAAEFIFQGRKVVVVANHLNSKRGDNALYGRVQPVTFKSEQRRHVLANMLAQFAK
                     EGAKHQANIVMLGDFNDFEFTKTIQLIEEGDMVNLVSRHDISDRYSYFHQGNNQTLDNI
                     LVSRHLLDHYEFDMVHVNSPFMEAHGRASDHDPLLLQLSFSEENDKAESSKQSVKAKKT
                     SKGKLLPKTGDSLVYVITLLGTASLLVPILLLTKGKKES"
     misc_feature    5108..5123
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.72"
                     /tool="antismash"
     misc_feature    5229..5240
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 18.98"
                     /tool="antismash"
     misc_feature    5458..5471
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 24.45"
                     /tool="antismash"
     gene            complement(5478..6596)
                     /locus_tag="DQN36_RS06230"
                     /old_locus_tag="NCTC13737_01232"
     CDS             complement(5478..6596)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990425.1"
                     /locus_tag="DQN36_RS06230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01232"
                     /product="ABC transporter permease"
                     /protein_id="WP_010922112.1"
                     /transl_table=11
                     /translation="MICFIKTLFVKIKRKKTSYVTFFLMPILTTLLALSLSFSNNNQAK
                     IGILDKDNSQISKQFIAQLKQNKKYDIFTKIKKEHIDHYLQDKSLEAVLTIDKGFSDKV
                     LQGKSQKLNIRSIANSEITEWVKAQTNYLLENYNIIGDVALGNEDTFNRILQKNQQLNY
                     DVKQVTLTDRSRSKAVSSTTTGFLLILMLGSTSVIYSGILADKSSQLYHRLMLSNLSRF
                     RYMLSYVCVGFVAFTIQIVIMLSLLKVFNISFFVPTSLLLIIFFLFSLLAIGFGLLIGA
                     ITQNSQQSSQLANLIVMPTSMLAGCLWPLSITPSYMQAIGKLLPQNWVLSAIAIFQSGG
                     TLSQAWPYLLALMGTALALISFSSLLLKPTKL"
     gene            complement(6593..7720)
                     /locus_tag="DQN36_RS06235"
                     /old_locus_tag="NCTC13737_01233"
     CDS             complement(6593..7720)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985266.1"
                     /locus_tag="DQN36_RS06235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01233"
                     /product="SagG family ABC transporter permease subunit"
                     /protein_id="WP_011284655.1"
                     /transl_table=11
                     /translation="MVLFHLIKKESLQIFRNRTALLMMVIFPILMIVILSFAFKSSFNT
                     ATTVPKLTIRYQLEGEKTDYQKNFLAFLKVLNQKLHLEAKPSNSLEKDRQRVSEGALTA
                     VLEVKKNQTIKVITNNINQQNADLINMLVKNYVDNAKTYDSIAALYPQQLNHIRKRSVD
                     YVKVSSIQTSKGMTSADYYAISMFTMITFYSMMSAMNLVLSDRQQRITNRIHLTGVSPS
                     LLVFGKLIGAMLATTVQLSLLYIFTRFVLRVNWGTNEWMLIGITASLVYLSVAIGIGLG
                     ISIKNEAFLTVASNTIIPIFAFLGGSYVPLTTLHSSIINQLSNISPIKWVNDSLFYLIF
                     GGQYNPIPVTLIVNISIGTIFIILALIGMRKQVTT"
     gene            complement(7729..8652)
                     /locus_tag="DQN36_RS06240"
                     /old_locus_tag="NCTC13737_01234"
     CDS             complement(7729..8652)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017604.1"
                     /locus_tag="DQN36_RS06240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01234"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_002990429.1"
                     /transl_table=11
                     /translation="MSFVQLTNVVKSYKNGKKAVNDVSLSIEAGNIYGLLGPNGAGKST
                     LINLILGLIPLSSGKITVLGQSQKTIRKISSQIGYVPQDIAVYPDLTAYENVELFGSLY
                     GLKGAQLKKQVLKSLEFVGLHSQAKQFPSQFSGGMKRRLNIACALVHSPKLIIFDEPTV
                     GIDPQSRNHILESIRLLNKEGATVIYTTHYMEEVEALCDYIFIMDHGQVIEEGPKFELE
                     KRYVANLANQIIVTLTDSRHLELADKPDWSLIEDGEKLMLKIDNSDMTSVVHQLTQANI
                     TFSEIRHNHLNLEEIFLHLTGKKLRD"
     gene            complement(8675..9358)
                     /locus_tag="DQN36_RS06245"
                     /old_locus_tag="NCTC13737_01235"
     CDS             complement(8675..9358)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985270.1"
                     /locus_tag="DQN36_RS06245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01235"
                     /product="SagF family protein"
                     /protein_id="WP_002994086.1"
                     /transl_table=11
                     /translation="MMLLVLLSFLGLTTLWLTSYRRRCLARWHLQWLMALSYQDFLDVL
                     LSLFQFVVIILVLFFYSATINLGEVLTFLTQTSWHWRILCYLVLYLMAIIEMTLLVLIL
                     IFDVLLQKDSRLLFKKITWLPFRQDKPVLSILLLGIVILVDSLFYLGLLILLGEQSLTS
                     LATLILGYGIVKACRYSGWLNVLLAFCLFTIVGLWAVTATLLYGWLVGAMILTVTYLMI
                     SCKEY"
     gene            complement(9355..10026)
                     /locus_tag="DQN36_RS06250"
                     /old_locus_tag="NCTC13737_01236"
     CDS             complement(9355..10026)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017602.1"
                     /locus_tag="DQN36_RS06250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01236"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_002985272.1"
                     /sec_met_domain="Abi (E-value: 1.1e-10, bitscore: 38.4,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLSIQCLNLCFLLVTFCPSIPMQAIFGKEDSGYAFNLIGFLRAT
                     LIYDILALVSIYVLSPQITLSLESIDSKTFFMGLVFCVLIVLIELVFLHGLRCWQKKQW
                     LPATFSFVGTTNDWSKIGYPLLLALFEETIYRFLWFNILAFQWHLPTIIVLIVTSFCYA
                     LNHLLMGKSIFYAKLVTGIIYGSIYMLTSQLWLVVIMHVGGNLLVECLSHLQTKKKKEV
                     T"
     gene            complement(10001..11359)
                     /locus_tag="DQN36_RS06255"
                     /old_locus_tag="NCTC13737_01237"
     CDS             complement(10001..11359)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407460.1"
                     /locus_tag="DQN36_RS06255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01237"
                     /product="YcaO-like family protein"
                     /protein_id="WP_002990434.1"
                     /sec_met_domain="YcaO (E-value: 6.3e-63, bitscore: 210.1,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 3.8e-111, bitscore:
                     368.2, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLYYYPSFNHIFDELKSLSGNRTGILNQSQVPVCNHPHDVYLKSI
                     TGQMPDYHKQFIGELSQVSYHIIGYGSYYEEALIKYLGESIERYATVIAGDLLSDRIVY
                     ASYNELKLLHKVMPLEYLQVFTQEQIALSCDLQMMMCDKMVTENDVLGWVKCPMFFEDA
                     EMYVPAQMLCVGYKTNETVGERRIIPGFSTGTASHKTLEAAMCNSLIEYIQIDSMMLSW
                     YTKKPCPKIIVDDPDIEVILEEARLGKDSLYDIIPIDMTVGEDNPLYTFGIILKNKYDE
                     GPYLLFGVQAGLDPKHALLRGIMEASAISYSYYYNLLYQKASLANIECEEPLFLDLDSN
                     VFYYAHPKDQDHKWKAFEPLISGEVLLSDLEDHSGKDKKEDLKTLLAYAKKVSPNAVFL
                     DITPPEALEKGWYVTRVLMPELLEMCIPAFPFANHPRMRQFGGVTNAFVHPMP"
     gene            complement(11379..12437)
                     /locus_tag="DQN36_RS06260"
                     /old_locus_tag="NCTC13737_01238"
     CDS             complement(11379..12437)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03603"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cytolysin_C_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985275.1"
                     /locus_tag="DQN36_RS06260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01238"
                     /product="streptolysin associated protein SagC"
                     /protein_id="WP_032464273.1"
                     /sec_met_domain="Cytolysin_C_RRE (E-value: 1.4e-40,
                     bitscore: 134.1, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03603 (E-value: 8.5e-140, bitscore:
                     462.5, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYQLNSNVRVVTFQDTFCFRKGIWDFNEAILDLTQEPQNLKIVY
                     QEIVSQLVKGVAIDTETYENTLEPETFANLMEVISGLYYNDMLMLEDDYNLEENVMKIL
                     MGNFRFMAQAGHMVSNAPVLFISDSTYVNESAELLAEQLHLQLQVASDDLKMLIQQTDV
                     SSRLDALEHRRNMNCLSEALCDYQSIIICQERLNIMMLRHLNEVSVAMKKQLVIGFVDG
                     PFLHTCTLNPPHSADFDSLERRVLARLQDSTLYQHFANQVLPATQDVSQAYLPLLNVLM
                     NLVVSEAFIIAQTGSSKFEGRLLSIYLPTLEIQVQDILKMSNSQTQGALAKLKYEDQQI
                     STREIVKKLLDE"
     aSDomain        complement(12168..12437)
                     /aSDomain="Cytolysin_C_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing discrete C protein in a
                     SLS/cytolysin LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_DQN36_RS06260_Cytolysin_C_RRE.1"
                     /evalue="2.40E-42"
                     /identifier="RREFam014.1"
                     /label="DQN36_RS06260"
                     /locus_tag="DQN36_RS06260"
                     /protein_end="90"
                     /protein_start="0"
                     /score="134.1"
                     /tool="antismash"
                     /translation="MKYQLNSNVRVVTFQDTFCFRKGIWDFNEAILDLTQEPQNLKIVY
                     QEIVSQLVKGVAIDTETYENTLEPETFANLMEVISGLYYNDMLML"
     gene            complement(12434..13384)
                     /gene="sagB"
                     /locus_tag="DQN36_RS06265"
                     /old_locus_tag="NCTC13737_01239"
     CDS             complement(12434..13384)
                     /codon_start=1
                     /gene="sagB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922108.1"
                     /locus_tag="DQN36_RS06265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01239"
                     /product="streptolysin S biosynthesis dehydrogenase SagB"
                     /protein_id="WP_002990438.1"
                     /sec_met_domain="PF00881 (E-value: 4.9e-32, bitscore:
                     108.0, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFFTKEQQPKENCPPITVEKARQLFEFNTNHLSLSDYHHQTVLK
                     TSKQLVAQHLMPNATDNLSQHFLMNYKANNNYLGFQASIVDFFTDSAVANFSSSYVYES
                     QEKIIRLPKPTKISTALSTCIIKRRSHRQFSDRQMPLQDLSNILYYACGVSSQASIRDG
                     ASDKITLRNCASGGGLYPIHLVFYARNISKLIDGFYEYLPYQHALRCYRHSSEENVRDF
                     AEYGAINAENCNIIIIYVYHYIKNTRKYGNQATAYAFIESGEIAQNIQLTATALTYGSI
                     DIGGYNKEYLQELLDLDGLGEHVIHMTLVGTKESQ"
     misc_feature    13582..13599
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 22.53"
                     /tool="antismash"
     gene            complement(13606..13767)
                     /gene="sagA"
                     /locus_tag="DQN36_RS06270"
                     /old_locus_tag="NCTC13737_01240"
     CDS             complement(13606..13767)
                     /codon_start=1
                     /gene="sagA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03602"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985285.1"
                     /locus_tag="DQN36_RS06270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01240"
                     /product="TOMM family cytolysin streptolysin S"
                     /protein_id="WP_002985285.1"
                     /sec_met_domain="TIGR03602 (E-value: 1.7e-29, bitscore:
                     98.4, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKFTSNILATSVAETTQVAPGGCCCCCTTCCFSIATGSGNSQGG
                     SGSYTPGK"
     misc_feature    14293..14306
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.06"
                     /tool="antismash"
     gene            <14330..14446
                     /locus_tag="DQN36_RS06275"
                     /pseudo=""
     CDS             <14330..14446
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611996.1"
                     /locus_tag="DQN36_RS06275"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="IS3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="QETFYSLEQLTLKTKEEVHWWNYHHLHSNLNYQTPITK"
     gene            complement(14632..19896)
                     /locus_tag="DQN36_RS06280"
                     /old_locus_tag="NCTC13737_01241"
     CDS             complement(14632..19896)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990440.1"
                     /locus_tag="DQN36_RS06280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01241"
                     /product="DUF1542 domain-containing protein"
                     /protein_id="WP_111704439.1"
                     /transl_table=11
                     /translation="MLKTVTVTKDQQNPISITLTEEEAKALKNKEQLKVSIKQKQSKKT
                     SKDFYLEVGIDPEVKAKQKEKLLELDKVKKQIEDLINGDAWLPEKPEGEKPVQNTNKEL
                     QLQELNKKYQMAKEAIESATTLEKVTEKYNEYTFEGEKEKYPNSLRNQYTQGDKDKEIE
                     KAKKSLGDLSDKVNGKIEEDKWLSDEVKKKQQQELEARKQKVNDSLKGSDSLKSLRETV
                     EKASSKNQKKPESFEDVYVPGNEETEKTKVRDILQKTYQKTEQNIETDPWLSPEQKKAQ
                     KENAKARLDAGLKAVETTESLDKLKEVESDFLKKEKAESIPSQHQAGTPEVARKTFLDN
                     FEKEAKKEIESIKNDVTLTDAEKATAKAKVEAQLQEAKGKAKESKSFDDLKNIQDKFNS
                     ELPHTPGKPLKDQQSDAIAELEKKQQEIEKAIEGDKTLPRDEKEKQIADSKAKLVAEKE
                     KVSKAPDADAVKKALESGKQEIAKAYVPQNLEDHKKKLLAELKQKANDTEKAIDFDKTL
                     TAKEKEEQKAKTKEELQKATEAVGAIDNREELDKKVPELKKAIEDTHVKGNLEGVKNKA
                     IEDLKKVHDETVAKINGDDTLDKATKEAQVKEADKALAAGKEAITKADDADKVSTAVTE
                     HTPKIKAAHKTGDLKKAQEEANTALDKAAEKEREEINNDITLTAKDKEQQLKEVETALT
                     KAKDNVKAAKTADAINDARDKGVATIDAVHKAGQDLGARKSGQVAKLEEAAKATKDKIS
                     ADPTLTSKEKEEQSKAVDAELKKAIEAVNAADTADKVDDALGKGVTDIKNQHKTGDPVV
                     ARREAHGKQLDRVAQETKDAIEKDPTLTTEEKAKQVKDVDAAKERGMAKLTEAKNADEL
                     DKAYGEGVTDIKNQHKSGDPIEARRGLHNKSIDEVAQATKDAITADTTLTEAEKETQRG
                     NVDKEATKAKEELAKAKDADALDKAYGDGVTSIKNQHKSGDPIEARRGLHNKSIDEVAQ
                     ATKDAITADTTLTEAEKETQRGNVDKEATKAKEGLAKAKDADALDKAYGDGVTSIKNQH
                     KSGKGLDVRKDEHKKALEAVAKRVTAEIEADPTLTPEVREQQKAEVQKELELATDKIAE
                     AKDADEADKAYGDGVTAIENAHVIGKGIEARKDLAKKDLAEAAAKTKALIIEDKTLTDD
                     QRKEQLSGVDTEYAKGIENIDAAKDAAGVDKAYSDGVRDILAQYKEGQNLNDRRNAAKE
                     FLLKEADKVTKLINDDPTLTHDQKVDQINKVEQAKLDAIKSVDDAQTADAINDALGKGI
                     ENINNQYQHGDGVDVRKATAKGDLEKEAAKVKALIAKDPTLTQADKDKQTAAVDAAKNT
                     AIAAVDKATTADGVNQELGKGITAINKAYRPGEAVKARKEAAKADLEKEAAKVKALIAK
                     DPTLTQADKDKQTAAVDAAKNTAIAAVDKATTAEGINQELGKGITAINKAYRPGEGVKA
                     RKEAAKADLEKEAAKVKALITNDPTLTKADKAKQTEAVAKALKAAIAAVDKATTAEGIN
                     QELGKGITAINKAYRPGEGVKARKEAAKANLEKVAKETKALISGDRYLSETEKAAQKQA
                     VEQALAKALGQVEAAKTVEAVKLAENLGTVAIRSAYVAGLAKDTDQATAALNEAKQAAI
                     EALKQAAAETLAKITTDAKLTEAQKAEQSENVSLALKTAIATVRSAQSIASVKEAKDKG
                     ITAIRAAYVPNKAVAKSSSANHLPKSGDANSIVLVGLGVMSLLLGMVLYSKKKESKD"
     misc_feature    complement(20601..20615)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 23.4"
                     /tool="antismash"
     gene            21248..22789
                     /locus_tag="DQN36_RS06285"
                     /old_locus_tag="NCTC13737_01242"
     CDS             21248..22789
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011284650.1"
                     /locus_tag="DQN36_RS06285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC13737_01242"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_111704262.1"
                     /transl_table=11
                     /translation="MLHLHLETKLQDKLSLLNILLDVSEVSIDQLCQETELKKQRVYNL
                     LIEMIKDLEDTLTLTICDDTVSIPYKTYQLKMPYFKKLYQTSIFLKMLCFLIEPGELSL
                     HDFIKREYISQATAYRIRTNCRKYLKKVGLNVRQNHVVGPEYRIRFLIALLHYQFGMTI
                     YDFDKTSMNKVVSLIINSNQAITLNDASKAPYEFSYFAILISLIWKRRHDNLGIPQTDA
                     FKHLKKLSIYHDIKMTSQEIIGKWYHPDLTDEDLDYIFLCFCTTNNSFHKDKWTPKKVK
                     ELFELVMTKTNGKTLKASLRPLLGNNILNSLPFKRILVSFSRLFISNLQVLLPDIHLFH
                     YLRRQQKRNKSFYNTLKTIVEEWMSAEGIVGKLPSYHLLLFTIQLEELLKTYLPPIPVY
                     LLTNNTAALDLMTNALSIYFPPAIATVMPVNVEIIPFKDIVKEKQSVIIADRQYLNLIQ
                     HLYQNQGHLFLYFLFSFRDVSEAYIHKAFLDFRQKRYDEFIVTLLDTYHKNLSSP"
ORIGIN
        1 cactaccaca agatgggcat agtttaggaa taagcattac ttcttgctgg ttccgcttac
       61 tcataacgac atttaagaca gcaggaataa tgtcccctgc cttatataca atcactgtat
      121 cgccaatacg gatatctttt tcggcaatat aatccacatt atgtagggtt gcacgactca
      181 cggttgtccc cgctagttgc acaggagtta gattcgctgt aggtgtgacc acgcctgttc
      241 gtcccactgt ccagtcaacc gaaaggattt ctgcctcttt ttcttctgct ggaaatttgt
      301 aagcaatggc ccagcgtgga gctttaaccg taaaccctag ctcttcttgc atggctaggc
      361 tattaacttt aataacaacg ccatctatgt cataagctaa ttgatctctt tttgcctcaa
      421 tagttttgat aaaatcccaa atctcatcca tagacgatgt gagttgataa tacggattta
      481 ctgaaaaacc tagatctgct aattctgcta agacctcatt ttgttgattt ctagctgtcg
      541 gactagcttc ttgatacaaa aaagtggcta gttgacgctt agcaaccact gccgtatcta
      601 gctgccttag tgtcccagcg gcagcatttc taggattagc aaattcagtc tccccatttt
      661 cttggcgtgc ttcattgatc gctttaaagg actgacgaga catgtaagcc tctcctcgaa
      721 cggtgatggt taaaggctca ctcaattggt gaggaatatc ctttattttt ttaatatttt
      781 ctgtgatatt ttcaccgata ttgccatcac cccgtgttgc tccaacctgt aagaagccat
      841 tctcataact caaggaaata gataaaccat caatttttaa ctctgctaga taggtggcat
      901 tcggaaattc ggccttgacg cgcttatcaa aagcatccag ctcctcacgt gaaaaagcat
      961 cctgcaaact aaaaagcgga tactgatgtc gatatttttc aaaccccttt aaaatagtcc
     1021 ctccaacctg ctgcgttggg ctatcttgca agacatactc gggatatgac tgctctaaag
     1081 tcaccagttc acgataaagc ttatcatagt cactgtcaga aactgatggg gcatctttag
     1141 tataatagtc ataacggtaa cggttaagaa gatctgttaa ttcttttatg cgttttttca
     1201 tacttttatt ttatcataaa agataacaaa tgagctattt tctatatcat aacaacatca
     1261 aaagtaatcg ttggccactc catatggtac tattagctaa agtgttaaat atttctatct
     1321 agaacgattt taacattaca aacaacataa aaaagagaag ggtattgacc caactctttt
     1381 gagtatgatg cattactaaa aggaaactct ttgagacaac ttatcaataa taagtgatcc
     1441 tatgagcaga gatactaatt ctcctaacgc agttgtaaac catgttaata aaaatggagc
     1501 tccaaagaag taaagttcga ttgctacagc aaacatggaa gttgcaaaaa agaaagaaaa
     1561 gtaaacaaaa gctttattaa aaataccatt aaaaagataa tctttttgat acttactaaa
     1621 caaaataaca cctaaggtca caaaaataag agttgaaccg ccgcctacaa agacatcaat
     1681 cagtccgaaa ctataaaagt tagcaatcat acatccaaga gtcaccgcaa taatatactt
     1741 gcgatgataa aaagctaaga aattcatcat ttcagatatt ctaaattgat acatcccata
     1801 agaaatcgca ttcaaaggtg gggtaatagt taagacaaca tacaaggcag ctactaaccc
     1861 aatgtgaaca tagtcgtgta cagtcaattt tgtcattttt tctcctttaa cgtctagata
     1921 actctcaaaa gctatctacg tttctaatat gcttggtgaa agggaactaa gcaccaaggg
     1981 ttgcaaagca acggttacat tgtaccataa aacaattagc ttgacaaaag tctttagcaa
     2041 gtaaagctgt cttattgtta tcttcttttg ttatcaatat tagtttttat atagtcatcc
     2101 attttagctt aaggtctaac gtaagtatat caagccttta acgactcttt atgaactcca
     2161 attcttcaaa tcgctatgat tcctttttgc ctttagtcaa taataaaata ggcactaata
     2221 aactagccgt tcctagtagc gttatcacat aaacaagact atctcctgtt tttggcaaca
     2281 gttttccttt tgaagttttt ttagctttta cactttgttt agaagactct gccttatcat
     2341 tttcttcaga aaatgataat tgaagtaaca atggatcatg atctgatgcg cgtccgtgag
     2401 cttccataaa tggggaattc acatgaacca tgtcaaattc gtagtgatca agtaaatggc
     2461 gtgaaactaa tatattatca agggtctgat tattgccttg gtgaaaataa gaataccgat
     2521 ctgaaatatc atgtcggctc accaagttaa ccatatcacc ttcttcgatt aattgaatcg
     2581 tctttgtgaa ttcaaaatca ttaaagtcac ctagcatcac aatattagct tggtgttttg
     2641 ccccttcttt cgcaaattgt gctagcatat tagccaagac gtgacgtctt tgctcagatt
     2701 taaaagtgac tggttgcaca cgaccataaa gagcattatc cccacgctta gagttcaaat
     2761 gatttgcaac aacaacgact ttacgacctt ggaagataaa ttctgctgct agcgatttac
     2821 gaacatcttt ccaagcggcg ttagttggat caattcgacc aacactaagg tttaattctc
     2881 cattaaccca agttagagca tcacgagcac cgccttttgg cttatcagaa agactgacgc
     2941 gctctggttg ataaaggaat cctgttcgaa tattaccacc tggttgacct ccgtcaacat
     3001 tattttctgg agcaatatca acataacgat aagttgggcc acctagtttt ttaatagcat
     3061 caatgaggcg ttgtgcgctt tgtgtcgcat ccgttgtccc atcatcagtc ggcccattat
     3121 tatcttggac ttcaattaat ccaataatgt ctggagcatt cagatcatga ataaaagatt
     3181 cggcaatccg tttgaccttc tcatctttag ttgaagaagg attggctgag aagttttcaa
     3241 tattgtaaga agcaatgctt aacttgctaa ggtctttttg caagtttgtt ttttcaggtt
     3301 ttagatgacc atccattaaa cttggcatgt ttttgctgtc atcaacaaag accttgtaat
     3361 taccatagct ataagatact ggcccaacta atcttccttt gtaatagtct cctgctttaa
     3421 taatttgttt gccttttttg aaaagaacag gaatcacatc tgtgttataa gaattagctg
     3481 gaagtaatac tccacctgaa ttatttaacg gtcttgtact agagccaggt aagacataaa
     3541 tttctttatt tttcattgga ccaaggattt tagcatcatc aaccgccact aacatgcctt
     3601 ccattgattc ccaataatca atagcgtctt cttctggatc aaacacacgc aagccatcat
     3661 tatcaataat attggctggc gcgatacgat ctttccctaa aacaagcggt gatggaactt
     3721 gagctgtccc tgttttggtc actgctttag ccacaatttg ggtgatggta aggtcagtct
     3781 gcttacgttc ctcataacca cgaccaaaga attcttccac ttcacctgaa atggtcaaaa
     3841 catcgccgac ttgaacctta gcgtttttag caaaaacacg aataccatct gaagtcgcta
     3901 aatcaccatc accattaaga tcttgaacat aaaaatgagt ggaatcgtct aaataagtga
     3961 caacaacctg ttctacggtg accgcttttt tgagaagtgg cgacgtatga ctagctcctt
     4021 gaatctcgcc tattttcaca atattacgag atgaagcatc actatttgag cttgtgacct
     4081 ttttaaccac ttccaattgt tcaagagaaa acggtcttaa ttgtaactga ctatcaacaa
     4141 tagacaatat ggctgtgagg ttaatcaaat caccctgact tattttagta acaacatcag
     4201 cccctttaac ccctgtacga tgatctatat gaacaactat acttttacca ctatcatccc
     4261 ttacaaggaa agatgtgttg ttatattgat cagttgataa ttctccaact gtcacgtgag
     4321 ataacttaac taatgttgag ggtgttgttg tttctaattc tgatattact gcttctttaa
     4381 cagaagtcgg aaaagataac tctaactttt tgtgtgcagt cacctgttgg agttgtaaat
     4441 cacctttaaa gcgagtaagt gtacctgtta attgaacaat atctccctta ctgtatccta
     4501 aatctttttg aggataaaca taaagtccaa taccttcact atcttgaata taaaagccat
     4561 agcctcccca gccattgatc acactcataa tcttgccagt aacagtatag gttctttctt
     4621 caggcccctt tcttacttga gcaatagact gttcagtagt tacttttact cctttatcag
     4681 gtgttggcaa aggtgttttt ctctcaccaa aatccacact tgctaggtaa ggtgatatga
     4741 cgggaaaatt cgatttatca ctaataacag attctctctt tggcctttgt gttacgattt
     4801 cattggcata agtcaaattt tggcgtgaag taacttcttc aacactagta agcgtaatag
     4861 ctagtgtcaa caatgaaaca gatattatac atttcttgtt aatcatgata tctcctttta
     4921 atgtgattag tttaagacaa caacaagatt ttatttttga atattaacct ccacctgaga
     4981 ctatgaattg ggatacactt tctgtttgca ttaattatac tatcaagtaa cacgattaga
     5041 tcttttcttt taatctgtta agtcacccaa ttaaagactt gtttgatctg acataacatc
     5101 acaagcaccc ctgatagcga acaagacagc tttatagcat tcgatacatg cttattgtaa
     5161 caaaaacatt tcataaaata aatacgtttt caaaactttt tttaataaca ttagttttta
     5221 tgtttattga aaacgttttt taaaataatt tgacaactca tttatcaaca aaaacgaact
     5281 ttatagaggg gtcgcttttg ataatatgct ctctaaaaaa cacagtaaca acagtaacat
     5341 cgcaatcgct tttaacaaaa gataagtgca ctagagaaaa tataagcaaa aagcaaccct
     5401 tttattgcat ataagccaat aaaagggcta cctggtagtt agctaactta ggaaagtatt
     5461 ttttaacaaa agactaatta tagtttggta ggttttaata ataaacttga aaaactaatc
     5521 aaagctagtg ctgttcccat tagagctaac aagtatggcc aagcctgaga taaggtccct
     5581 ccactttgaa aaatagctat ggctgataaa acccaatttt gtggtaataa cttaccaatt
     5641 gcctgcatat aagaaggcgt aatagacaat ggccataaac agccagccaa cattgaagtc
     5701 ggcattacaa taagattagc taactggcta ctttgttggg aattttgtgt gatagctcca
     5761 atcagcaggc caaagcctat cgctaataaa ctaaaaagga aaaaaataat caaaagaagt
     5821 gatgtcggaa caaaaaaact aatattaaat acttttaaca aactcagcat aatgacaatt
     5881 tgaatcgtaa aagcaacaaa tcctacacag acgtaactca acatatagcg aaaacgagat
     5941 aagttcgata acattaatcg atggtataac tgactagatt tatctgccaa aataccactg
     6001 taaatcacgc tcgtactacc taacattaga ataagcaaaa atcctgtcgt tgtggaagat
     6061 actgctttgc tacgtgatcg gtctgtcaaa gttacttgct taacatcata atttaactgt
     6121 tggttttttt ggagaattct attaaaagta tcttcgttac ctagagccac atcccctata
     6181 atattataat tttccaatag ataattggtc tgtgccttta cccactctgt aatttcgcta
     6241 ttagcaatcg aacgtatatt gagtttttga gattttcctt gcaacacttt atctgagaat
     6301 cctttgtcaa tagtcaatac cgcttctaga gatttatctt gaaggtagtg atcaatatgc
     6361 tcttttttga ttttggtaaa aatgtcgtac tttttgtttt gctttagttg agcaataaat
     6421 tgtttagata tctgactatt atctttatct aatatcccaa ttttagcctg attattattt
     6481 gaaaaactca aagataaagc caaaagtgtc gttaaaatag gcattaaaaa gaatgtcaca
     6541 taacttgttt ttttgcgctt tatcttaaca aatagagttt ttataaaaca aatcatgtcg
     6601 tcacctgctt tctcatacct atcaatgcca atattataaa aattgttccg atactaatat
     6661 taacgatcaa agttacagga atcggattat attgaccacc aaaaataaga tagaacaaac
     6721 tatcattaac ccatttaata ggagatatat tcgataattg attaataata gagctgtgta
     6781 atgttgtcaa tggaacgtaa ctgcctccta aaaaggcgaa tataggaata atagtattgg
     6841 atgcaaccgt taaaaaagcc tcatttttaa tgcttatgcc tagcccgata cctatagcta
     6901 cagagagata gactaaggag gctgttatac caataagcat ccactcatta gtgccccaat
     6961 taactcgtaa aacaaacctt gtaaaaatgt ataaaagact caattgaaca gttgttgcta
     7021 acatagcacc tattaatttc ccaaagacca aaagacttgg agaaactcct gttaagtgaa
     7081 tacgatttgt aatccgttgt tgacgatctg acaaaacaag gttcatcgca gacatcatac
     7141 tataaaaagt aatcatggta aacatggaaa tagcataata atcagctgat gtcattcctt
     7201 tacttgtctg tattgaactg accttaacat agtccacact tcgctttctg atatgattta
     7261 attgttgagg ataaagagct gctatcgagt cataagtttt agcattatct acataatttt
     7321 ttactagcat attgatcaaa tctgcatttt gctgattaat attattagta ataaccttaa
     7381 tggtctgatt cttcttcact tctaaaacag ccgttaaggc tccttcactg accctttgtc
     7441 gatctttttc aagagaatta ctaggtttag cctctaaatg aagtttttgg tttaaaactt
     7501 ttaaaaaagc aagaaaattt ttctggtaat ccgttttttc accctctaat tggtaacgaa
     7561 tggtcaattt agggactgtt gtcgcagtat taaaacttga tttaaaggca aaacttaaaa
     7621 taacgatcat caaaattgga aaaatcacca tcatcaataa ggctgttcgg tttctaaaaa
     7681 tctgtaaact ttcttttttg attaaatgaa ataaaaccat agtaacctct aatctcgtaa
     7741 cttcttacct gttaagtgta agaaaatttc ttctaaattc aaatggttat gtctaatctc
     7801 gctaaaagta atattggcct gtgtgagctg atgaacaact gatgtcatat cactattatc
     7861 aatcttcaac atgagttttt ctccatcttc tatcaaagac caatcaggct tatctgccag
     7921 ttccaaatga cgtgaatctg ttagagttac aataatctgg tttgctagat ttgcaacgta
     7981 acgtttttcc agttcaaatt taggtccttc ttcaataact tgaccatgat ccataataaa
     8041 aatataatca caaagagcct ctacttcttc catgtaatgg gtcgtataaa taactgtggc
     8101 accttctttg tttagcaaac gaatcgactc taaaatatga ttacgtgatt gaggatcaat
     8161 ccctacagtc ggttcgtcaa aaatgattaa tttaggtgaa tgaactagcg cacaagcgat
     8221 atttaaccgt ctcttcattc ctcctgagaa ttgacttgga aactgcttag cttgggagtg
     8281 tagccccaca aattctaaac tttttagaac ttgtttttta agctgagctc cctttaagcc
     8341 ataaagtgac ccaaatagtt ctacattttc ataagcagtt aggtctggat aaacagcaat
     8401 gtcttgagga acataaccta tctgcgaact tatttttcga atagtctttt gggattgccc
     8461 taaaacagta attttaccgg aactcaaagg gatcaagcct aagataagat taatcaaggt
     8521 agacttacca gcaccatttg gtcctaacaa accataaata ttacctgctt caatagacaa
     8581 ggaaacatca ttgacagctt tcttgccgtt tttgtaggac ttgacaacat ttgttaattg
     8641 tacaaaactc atatatcact cctttttaat attgctaata ctctttgcaa ctaatcatca
     8701 aataagtcac cgttaatatc atcgcaccta ctagccaacc atataataaa gttgccgtaa
     8761 ctgcccatag tccaactata gtgaaaagac aaaaagctaa tagtacattt aaccagcctg
     8821 aatagcgaca agccttgact atcccataac ctaaaataag cgttgctaaa ctggttagcg
     8881 actgttctcc taataatata agcaagccca aataaaagag actgtctact agaataacta
     8941 tgcctagtaa aagtatactt aagactggtt tatcttgtct aaaaggcagc caagttattt
     9001 ttttaaagag caatcgactg tctttctgga gcaaaacatc aaagataaga attaaaacta
     9061 aaagcgtcat ctctatgatg gccataagat ataacactaa ataacaaaga atccgccaat
     9121 gccagctagt ttgtgtcaaa aaggtcagaa cctctcctag attaatagta gctgagtaaa
     9181 agaacaaaac aagtataata acgacaaatt gaaacagact cagtaagaca tctaaaaaat
     9241 cttgatagga taaggccatt aaccattgaa gatgccatct agccaaacaa cgtcttcgat
     9301 aactggtcaa ccaaagagta gttagaccta aaaacgacag caaaaccaat agcatcatgt
     9361 cacctccttc ttcttttttg tttgaagatg gctaagacac tcaactagca agttacctcc
     9421 tacatgcatt atcacaacca accacaattg actagtcagc atgtaaatac taccataaat
     9481 gatgcctgtt accaacttag cataaaaaat ggatttcccc atcaataagt gatttaaagc
     9541 atagcaaaaa ctagttacaa ttaaaacaat aattgttggt aaatgccatt gaaaagctaa
     9601 tatattaaac cacaaaaaac gataaatcgt ctcttcaaat aaagctagta ataaaggata
     9661 gccaatctta gaccaatcat ttgtcgttcc tacaaacgag aaagttgcag gaagccattg
     9721 ctttttttgc caacaacgta aaccatgtaa gaaaacgagt tcaatcagta ctatcaagac
     9781 gcaaaataca agtcccataa agaacgtctt actatcaata ctttcaagag acaaggttat
     9841 ttgaggtgac aaaacataaa tacttaccaa agccaaaatg tcataaatca gagttgctct
     9901 tagaaaacca attaaattaa atgcataacc actatcttcc tttccaaaaa tagcttgcat
     9961 aggaattgaa ggacaaaaag ttaccaacaa aaaacaaaga ttaaggcatt ggatggacaa
    10021 aggcatttgt tacacctcca aactgtctca ttcgtggatg attagcaaaa ggaaatgctg
    10081 gtatacacat ttcaagaagt tctggcatca gaactcgcgt gacgtaccag cctttttcta
    10141 gagcttcagg aggtgtaata tctaaaaaga cagcattagg actgactttc ttagcataag
    10201 ctaataaagt cttcaaatct tcttttttat ctttaccaga atgatcttcc aaatcactta
    10261 acagaacttc tcctgaaatc aaaggttcaa aggccttcca tttatggtct tggtccttgg
    10321 gatgtgcata atagaagaca ttactatcta aatctaaaaa caaaggttct tcgcattcaa
    10381 tatttgcaag ggaagctttt tgatataaaa gattatagta gtaactatag ctaatagctg
    10441 aagcttccat gatccctctt agcaaagcat gtttaggatc taacccagcc tgcactccaa
    10501 acaagaggta aggcccttca tcatatttat ttttgagaat gattccaaac gtataaagag
    10561 gattatcttc tcctacagtc atatcgatag gaataatgtc gtatagactg tcttttccca
    10621 gtctagcttc ttctaaaatc acttcaatat caggatcatc aacaataatc ttggggcaag
    10681 gcttcttagt ataccagcta agcatcattg aatcgatctg gatgtattca atcaaactgt
    10741 tgcacatagc cgcttctaac gttttgtgag aagctgttcc cgtagaaaat cctggtatta
    10801 tccgtctttc tcctacagtc tcatttgttt tatacccaac acaaagcatt tgagctggaa
    10861 catacatctc tgcgtcctca aagaacatgg gacatttaac ccagcccaat acatcgttct
    10921 cagttaccat tttatcgcac atcatcattt gcaagtcaca agataatgcg atctgttctt
    10981 gagtaaacac ttgcaagtat tctaaaggca tcactttatg taacagtttt aactcattat
    11041 aagaagcata gacaatccga tctgatagta agtctccggc aattacagta gcatagcgtt
    11101 caatactttc tcctaaatac ttgataagtg cttcttcata gtaactgccg taaccaataa
    11161 tgtgataact aacttgactc aactcaccta taaattgttt atgataatct ggcatttggc
    11221 cagtaatact ttttaagtaa acatcgtgag gatggttgca aactggaact tgagattgat
    11281 ttaagatacc tgttcgattg ccacttaaac tttttaattc atcaaaaata tgattaaaag
    11341 aaggataata gtataacata atagattctc cttataggtt actcgtcaag gagtttttta
    11401 acaatctcac gtgttgatat ctgctgatcc tcatatttta attttgccaa agctccttgt
    11461 gtctgtgaat tagacatttt caaaatgtct tggacctgaa tctcaagcgt cggtaagtaa
    11521 atgcttaata aacgtccctc aaatttagaa ctacctgttt gagcaataat gaaagcttcg
    11581 ctaacgacta aattcattaa aacatttaac aatggtaaat aggcctggct cacatcttgt
    11641 gttgctggta aaacctgatt agcaaaatgt tgatagagag ttgagtcttg taaacgtgcc
    11701 aaaactcttc tttctaagct atcaaagtca gcactatggg gaggattcaa agtacaagtg
    11761 tgcaaaaatg gtccatctac aaaaccaatc actaattgtt ttttcatagc tacgctaact
    11821 tcattcaagt gtcgcaacat cataatattc aagcgttctt gacaaataat aatactttgg
    11881 taatcgcaca aggcttctga taaacaattc atgttacggc gatgctccaa agcatctaaa
    11941 cgcgaactaa catctgtctg ctgaattaac atttttaagt catcgctagc cacttgcaat
    12001 tgtaaatgca gttgttcagc tagcaactca gcagattcat taacataagt cgaatcactg
    12061 ataaacaaaa caggagcatt gcttaccata tgacctgctt gcgccataaa acggaaatta
    12121 cccattaaaa ttttcatgac attttcttca agattgtagt catcctcaag catcagcata
    12181 tcattgtaat acaagcctga aatgacttcc attaaattag cgaacgtctc aggttctaaa
    12241 gtattttcat aagtttcagt atcaatggct actcccttaa ccaactgtga aactatttct
    12301 tgataaacta tctttaaatt ttgaggttct tgtgtcaaat ctagaatggc ttcattaaag
    12361 tcccagattc cttttctaaa acaaaatgta tcttgaaatg tcacgacacg aacattacta
    12421 ttaagttgat atttcattga gactccttag ttcctacgag tgtcatgtga atcacatgct
    12481 ctcctagccc atctaaatct aataattctt ggagatattc cttattataa ccaccaatat
    12541 caatacttcc ataagttaag gcagttgcag tcaattgaat attctgggct atttctcctg
    12601 attcaataaa agcataggca gtcgcctgat tcccatattt acgtgtattt tttatgtaat
    12661 ggtagacata aataataata atattacaat tttcagcatt aatagcaccg tattccgcaa
    12721 aatctctaac gttttcctca gagctatgcc gataacacct tagtgcatgc tgatagggta
    12781 gatattcata gaaaccatct attaatttac tgatgtttct agcataaaaa actaaatgaa
    12841 tagggtataa acctccacct gaagcacagt ttctgagtgt aatcttatct gatgctccat
    12901 ctctaattga tgcttgtgaa ctaacaccac atgcataata aagaatgttt gataaatctt
    12961 gaagaggcat ttgtctatct gaaaattgac gatgacttct tcgttttata atacatgtcg
    13021 acagagcagt tgatatcttg gtaggttttg gtaaacgaat tatcttttcc tgactttcat
    13081 aaacgtaact acttgaaaaa ttagcaacgg cagaatctgt aaaaaagtcg acaatactag
    13141 cttggaagcc taaataatta ttattagctt tatagttcat caaaaaatgt tgactaagat
    13201 tatcggttgc attaggcatt aaatgttgag caactagctg ctttgacgtt tttagcaccg
    13261 tttgatgatg gtaatccgat aaggacaagt ggtttgtatt aaattcaaac aattgccttg
    13321 ctttttcaac agttattggc ggacaattct ctttaggttg ttgttccttt gtaaaaaatg
    13381 acataactat ctttcctatc tcattttact aaacatatag taattagcag gtactgtcta
    13441 gtacctgcta attacctgag acgttagcat caagaagatt acttttgtct catgttttct
    13501 aacacctcta tgccattcat ctataatcag aagttaccaa agataactta gttgctagca
    13561 aactcattac cttaatatca ctatcacata gagatgctaa atagattatt tacctggcgt
    13621 ataacttccg ctaccacctt gagaattacc acttccagta gcaattgaga agcaacaagt
    13681 agtacagcag caacagcagc ctccaggagc aacttgagtt gtttcagcta cactagtagc
    13741 taaaatattt gaagtaaatt ttaacataag gtttacctcc ttatctaata agtaactgat
    13801 aagaacgcga gtcgtttatt tttaacctta ttttaaaaat aaagttaaca caacaaggac
    13861 aaggctagct caattgtact gttgtaacac aacaactatc tagttcttat cacttttatt
    13921 atagtaaaaa atgattaata tgtaaaccct ttctttttaa tattatcaaa aatgacaaaa
    13981 aaaataataa ttgattaata tagaaacaat tatgatctaa tatactgaat tttataatag
    14041 attctatcaa taactatgtg taaacaatca agtagaaatg tctttattaa gcgaatcaat
    14101 caaggttgta gagtaaatac tggactagat ttcatgtaga aattagtaaa agttaggaga
    14161 ttttttggtc gtttcaaacg ataacatcat cttcttataa caagaacttc actcagagat
    14221 aaactattct aatactttag tagcctcttt tgagcttgta gcacgaaaat tcgctcgaac
    14281 tgatttaaaa taggcatttt atctgctcgc ttgatcccta ctgcgcaacc aagaaacctt
    14341 ttattcacta gaacaattaa cccttaaaac caaggaggaa gtccactggt ggaactacca
    14401 tcaccttcac agtaatctta attatcaaac acctataact aaatgagtca tcgtttgaac
    14461 aaaaaacgcc ttataaattc tgtacagaaa actgttgcct tttcaattga actttgaaat
    14521 gttttcaata cactccgttc ttgggcactt acgatccaaa aaaccaaggt gatttcaaaa
    14581 tcaccttggt ttgaaaatat agtagaaagc aatttggata aagccaggtt cttagtcttt
    14641 actttctttt ttcttgctat aaagcaccat acctaaaaga agagacataa ctcctaagcc
    14701 aacaagaaca attgagtttg catcacctga ttttggaaga tggttcgctg acgatgattt
    14761 tgcgactgcc ttattaggca cataggctgc acggatagca gtaatacctt tatcttttgc
    14821 ttctttcaca gacgcaatag attgtgctga acgaacagtc gcaatagccg tcttaagcgc
    14881 taatgataca ttttctgatt gttcagcttt ttgagcttca gtcaatttag catcagttgt
    14941 aatcttagca agtgtttctg ccgcagcttg tttaagagct tcaatagcag cttgtttcgc
    15001 ttcgttaaga gcagctgttg cttgatcagt atctttagct aaaccagcaa catatgctga
    15061 acggatagct acagtaccaa ggttttctgc caacttaaca gcttcaactg tcttagcagc
    15121 ctcaacttga ccaagtgctt tcgcaagagc ttgctcaaca gcttgttttt gggctgcttt
    15181 ttcagtttcg ctcaagtaac ggtctcctga aataagagct ttagtttctt tagctacttt
    15241 ttcaagatta gctttagcag cttctttacg tgctttaaca ccttcacctg gacggtaagc
    15301 tttgttgata gctgtgatgc ctttaccaag ttcttggtta atgccttcag ctgttgtcgc
    15361 tttatcaacc gctgcaatag cagctttaag ggctttagca acagcttctg tttgtttagc
    15421 tttatcagct tttgttaagg ttgggtcgtt agtaataaga gctttcactt tagcagcttc
    15481 tttttcaaga tcagctttag cggcttcttt acgtgcttta acaccttcac ctggacggta
    15541 agctttattg atagctgtga tgcctttacc aagttcttgg ttaatgcctt cagctgttgt
    15601 cgctttatca accgctgcaa tagctgtatt cttagctgcg tcaaccgctg ctgtttgttt
    15661 gtctttatca gcttgagtta aggtcggatc cttagcaata agagctttca ctttagcagc
    15721 ttctttttca agatcagctt tagcggcttc tttacgtgct ttaacagctt cacctggacg
    15781 gtaagctttg ttgatagctg tgatgccttt accaagttct tggttaacac catctgctgt
    15841 tgtcgcttta tcaaccgctg caattgctgt attcttagct gcgtcaaccg ctgctgtttg
    15901 tttgtcttta tcagcttgag tcaaggttgg atccttagca ataagagctt tcactttagc
    15961 agcttctttt tcaagatcgc ctttggcagt cgctttacga acatcaacgc catcgccatg
    16021 ttggtattgg ttgttgatgt tttcaatacc cttaccaaga gcatcattga tagcatcagc
    16081 tgtttgagca tcatcaacag acttgattgc gtctaactta gcttgttcaa ctttgttgat
    16141 ttgatcaact ttttggtcat gagtcaaggt tggatcatca ttgattagtt tcgtcacttt
    16201 gtctgcttct ttaagaagaa attctttggc agcattacga cgatcattaa ggttttgacc
    16261 ttctttgtac tgtgccagga tgtcacgaac accgtcacta tatgctttat caacacctgc
    16321 agcatcctta gctgcatcaa tattctcgat acctttagca tactctgtat caacacctga
    16381 taactgttct ttacgttgat catcagtaag cgttttgtct tcaataatga gagcttttgt
    16441 cttagcagca gcttcagcaa ggtctttctt agcaaggtct ttacgagctt cgataccttt
    16501 accaataacg tgggcatttt cgatcgctgt gacaccgtca ccgtaagctt tgtctgcttc
    16561 atctgcatct ttagcttcag caatcttatc agtcgcaagt tcaagctctt tttgaacctc
    16621 tgctttttgt tgttctctca cttctggtgt taaggttgga tcagcctcaa tttcagcagt
    16681 gacacgttta gcaacagctt caagagcttt cttgtgctca tctttacgaa cgtcaagacc
    16741 tttacctgac ttgtgttggt tcttgatgct ggttacaccg tcaccgtacg ctttgtctaa
    16801 agcatcagca tctttagcct tagcaagtcc ttctttagct ttagttgctt ctttatcaac
    16861 attgccacgt tgtgtttctt tttcggcttc agtcaaagtc gtatctgctg tgatagcgtc
    16921 cttagttgct tgcgccactt cgtcgattga cttgttgtgt aatccacgac gagcttcgat
    16981 agggtcacct gacttgtgtt ggttcttgat gctggttaca ccgtcaccgt acgctttgtc
    17041 taaagcatca gcatctttag ccttagcaag ttcttcttta gctttagttg cttctttatc
    17101 aacattgcca cgttgtgttt ctttttcagc ttcagtcaaa gtcgtatctg ctgtgatagc
    17161 gtccttagtt gcttgcgcca cttcgtcgat tgacttgttg tgtaatccac gacgagcttc
    17221 gatagggtca cctgacttgt gttggttctt gatgtctgta acaccttcac cgtaagcttt
    17281 gtctaactca tcagcattct tagcttcagt aagcttagcc atgcctcttt ctttagcggc
    17341 atctacgtct ttaacttgtt tagctttttc ttcagtcgtc aaagtagggt ctttttcaat
    17401 cgcatcttta gtttcttgag cgactctatc aagttgctta ccatgagcct cacgacgagc
    17461 tacgacaggg tcacctgtct tatgttggtt cttgatgtct gtgacacctt taccaagagc
    17521 atcgtcaacc ttgtcagctg tgtcagctgc gttaacagct tctatcgctt tcttaagttc
    17581 agcgtcaaca gctttagatt gctcttcttt ttctttgctt gtcaaagttg gatcagctga
    17641 aatcttgtct ttcgttgctt tagctgcttc ttcaagttta gcgacttgac ctgacttacg
    17701 agcacctaag tcttgacctg ctttatggac ggcatcaatt gttgctacgc ctttatcacg
    17761 tgcgtcattg atagcgtctg ctgtcttagc agctttcacg ttatctttag ctttagtaag
    17821 agctgtctca acttctttca gttgttgttc tttgtctttt gccgttaatg tgatatcatt
    17881 attgatttct tcacgttctt tttcagctgc tttgtcaaga gctgtgttag cctcttcttg
    17941 agctttttta aggtcaccag ttttatgtgc tgctttaatt tttggtgtgt gctctgtaac
    18001 agctgtactt actttatcag catcatctgc tttagtgata gcttctttac ctgctgccaa
    18061 agctttgtca gcttctttca cttgagcttc tttagtagct ttgtcaaggg tatcatcacc
    18121 atttatctta gcaactgttt cgtcatgaac ttttttaaga tcttcaatag ccttattctt
    18181 aacaccttca agattacctt taacgtgagt gtcttcaata gctttcttaa gttctgggac
    18241 ttttttatct agttcttcac gattgtcaat tgctccaaca gcttctgttg ctttttgaag
    18301 ttcttctttt gttttcgctt tttgctcttc tttttctttc gctgtcaaag ttttatcgaa
    18361 atcaatcgct ttttcagtat catttgcttt ttgcttcaac tctgcaagaa gttttttctt
    18421 gtgatcttct aagttttgtg gaacataagc cttagcaatt tcttgcttac ctgactcaag
    18481 agctttctta acagcatcag catcaggtgc tttagaaact ttttccttct cagcgactaa
    18541 tttcgcttta gaatcagcaa tctgtttttc tttttcgtct cttggtaatg ttttatcacc
    18601 ctcaatagct ttttcaattt cttgctgctt cttctctaat tctgcaatag catcagattg
    18661 ttgatcttta agcggcttac ctggtgtgtg tggtaattca gaattgaact tatcttgaat
    18721 gttcttcaaa tcatcaaacg attttgattc cttagcctta cctttagctt cttgaagttg
    18781 tgcttctact ttagctttag ctgttgcttt ttcagcatct gttaatgtaa cgtcattttt
    18841 aattgattca atctcttttt tagcttcttt ttcaaagtta tctaagaaag ttttgcgagc
    18901 aacttcagga gttcctgctt gatgttgaga tggaatagat tctgcttttt cttttttaag
    18961 gaagtcactc tcaacttctt taagtttatc taaactttct gtagtttcga cagctttcaa
    19021 acctgcatct aatcttgctt tagcgttttc tttttgagct tttttctgtt ccggactcaa
    19081 ccatggatct gtttcaatat tttgctctgt tttttgataa gttttttgaa gtatatcacg
    19141 aacttttgtt ttttcagttt cttcatttcc aggaacataa acatcttcaa aagattctgg
    19201 ttttttctga tttttagaag aagctttttc cactgtttct ctcaatgatt ttaaactatc
    19261 agatccttta agagagtcat ttactttttg tttacgcgct tctaattctt gctgttgttt
    19321 ttttttaact tcgtcagata gccacttatc ttcttcaatc tttccattta ctttatcgct
    19381 taaatcaccc agtgattttt tagctttttc tatttcttta tctttatctc cttgagtata
    19441 ttggttacgt aaagaatttg gatacttttc tttttctcct tcgaatgtgt attcgttata
    19501 tttttcagta actttttcaa gagttgtagc actttcaatt gcctctttgg ccatctgata
    19561 cttcttgttc agttcttgta actgtaattc tttattagta ttttgtactg gtttttcgcc
    19621 ttccggtttt tctggtagcc atgcatcacc attgattaag tcttcaattt gcttttttac
    19681 tttgtctagt tccaagagtt tttctttttg ctttgcttta acttcaggat caattcctac
    19741 ctcaaggtaa aagtccttag aagtcttttt tgattgcttt tgtttaatgc ttacttttaa
    19801 ctgttctttg ttttttaaag ctttagcttc ttcctctgtt aaagttattg atataggatt
    19861 ttgttgatct tttgtaactg taactgtctt taacaaatct ccattaggct tgaaaaggct
    19921 tatctcatca ccttcgaagt ttgttcttcc atcgtctgat tttaatgtca attctacatt
    19981 tttgtttcca acgtaagcaa cccctttttc tagttgactt gggtttgtaa catcaataat
    20041 tttgaagttt ttaaactcga catcaagatt gccttgcggt ttgctcacaa ctttagataa
    20101 taatacaaga gacataggac cttcttttaa agttctaaaa gatattgttt tagctcctgg
    20161 tttcctttgt ctaaaacctt gttcctcacc ttctatttct accttagaag catatgcact
    20221 ctgttctgaa atgttgaagg aatcatctat agttttatta aaagcactac ctatacgata
    20281 atcaactgtt attcccggcg caatctgacc ttgttcaaaa gttatcttat agtcatggtc
    20341 ttttattaaa gatttagtgt tgaccttaaa cgctacagaa tatggaggtt tcgttttatt
    20401 tgtatatcta gctgcaatag aatctttggt tattttgaca tagctatctt taacaggtcc
    20461 attatgttca tgccatcccg gctcttcaac tttgttagcc ggaacaaggt gaaacttata
    20521 ttgacctgta gcaccgtctg aatagaagcg accagaagag ccttcggcag atagtttcca
    20581 agttccgtta aaatcaatca aattgtctga aacttccgca gcctttacaa ccatcacgcc
    20641 attagattgg ctgaatccag taggtacggc aactccgagg ccgactgtta aaagcataca
    20701 tgaactaaca aagagttttt tgaccttacg cattctccaa tttttttgtt tcacatcttg
    20761 gtgttttaaa aacattctgt gttccccctt atttttttca tgcctatctt atttgacgtt
    20821 gtcagccagt agacacccag actgactgat gacgtgctct acgcttgtag agagtttacg
    20881 ttcctatcac agaatttaag gaatcctcct taacttatct tagtcaccgt agaaaccttt
    20941 attttctata ttcagacagt ttaacatgcc ccggaacgtt acagctgatt agaatttaaa
    21001 tgaattatta atttttctaa tcaacttatt atatcaactt aaatttaccc aattcaatag
    21061 attttttatc aatcccgacg ctttttcata cctaaaatta agaatattca gctgcatttt
    21121 gcttatatct gacattctca atactcctta aacacgcgtc accattgaat tatttgactg
    21181 ttttatttaa ttatgtgata attaaataaa tacgagtttc tgctataaaa atgaaaggag
    21241 ttcagttatg ttacaccttc atctagaaac caaattacaa gataaattat cactgctcaa
    21301 cattttgtta gacgtttccg aagtctccat agaccagttg tgtcaggaaa ccgaactcaa
    21361 aaaacaacgt gtctacaact tactcattga aatgattaag gatttagaag acaccctcac
    21421 cttaaccatt tgtgacgaca ctgtttctat cccctataag acctaccaac ttaaaatgcc
    21481 ttattttaag aaactctatc aaacctcgat attcttaaag atgttatgtt ttttaattga
    21541 accaggagag ctgagcctac acgacttcat taaacgagag tatatttccc aagccaccgc
    21601 ttaccgtatc aggaccaatt gtcggaaata cttgaaaaag gtaggtttaa acgttcggca
    21661 aaaccatgtt gttggaccag aataccgtat ccgctttctg atcgccttgt tgcactatca
    21721 gtttggtatg accatttatg attttgataa aacatcaatg aataaagtgg tttcgctgat
    21781 tataaactcc aatcaagcca tcacacttaa tgatgccagt aaagcccctt atgaattttc
    21841 atactttgcc attctgatat cccttatatg gaaacggcga catgataact tgggtattcc
    21901 tcagacagat gcattcaaac acttgaaaaa actgtctatc tatcacgata tcaaaatgac
    21961 cagtcaggaa atcatcggaa aatggtacca tcctgattta actgatgagg atttggatta
    22021 tattttctta tgtttttgca ccaccaataa ttctttccat aaggataaat ggacacctaa
    22081 aaaagtgaaa gaattgtttg agttggtgat gacaaaaaca aatggaaaaa ccttgaaagc
    22141 atccctgcgt ccactactag gcaataatat cctaaactcc cttcctttca aacggatttt
    22201 ggtttccttc tcacgtctat ttatcagtaa tcttcaagtt ttgttacctg atatacactt
    22261 gttccattac ctcagaagac agcaaaaacg aaacaagagc ttctacaata ctctaaaaac
    22321 catcgttgag gaatggatga gcgcagaagg catcgtgggg aaactgccgt cctatcattt
    22381 actgctcttc acgatacagt tagaggaact cctaaaaaca tatttgccac cgatacctgt
    22441 ctatcttttg accaataaca ctgctgcgct ggatttgatg accaatgcac tctcaattta
    22501 cttcccgcca gctattgcaa cggttatgcc tgtcaatgtc gaaatcattc ctttcaaaga
    22561 tattgttaag gaaaagcaga gtgtcattat cgcagatagg caatacctga acctgataca
    22621 gcatttgtac cagaatcaag ggcatttgtt cttgtatttc ttgtttagtt ttagagacgt
    22681 ttctgaggct tacattcata aggcatttct agacttccgc caaaaacggt acgatgagtt
    22741 tatcgtgacc ttgttggaca cttaccacaa gaacctgtct tctccttgag tgataaagat
    22801 gctttgttca cattaccaaa aggctcagca agctaatatt gttctaaacg gcatccacaa
    22861 ggtgagggaa ctgaacgtaa gagtcaactg cagtaatttg agaaataccg ttcgactgat
    22921 ggattgttag ggcattgaga ttattaagaa gaaacagtat cagacttatt cttctagaat
    22981 aaaggaaaaa atcattaata acattttgaa aaacggctat actattgttt aaaaggcaaa
    23041 aggaagacca tcacaacagg agtctattct cgtcggcttc agtccttcct tgagaaaaat
    23101 ggctacgctt atacacacaa ctcaatcctt tagaaaatta gatagtctac gggtgcgtaa
    23161 agcggataag ttagacactg aaaaattggc tcagtctcaa tttattctag ttggaaaacc
    23221 aacttacgtt caggaagaag tttatcagct gctacgtgac ttgagtcgct tctatcaaaa
    23281 cttgactgag gataatattg ttcgagagtt aagaatcgcc ttcacaagat cttacaagtc
    23341 acttttcctg aactggaaca catcttattt gcaccaactg ttgagtaata ctggaatgtg
    23401 gtaacggctt ttccatgtaa tagctttgta ctagagctag ctgacaaagc attgtcagct
    23461 agcatccgtc aatctacctc taaacgtatc tctgacaagc gtgggatcta cttagtggaa
    23521 aaacttgtct cattagccaa gcagtcttat tttactgtta cgaaaacctc tccgatgata
    23581 gaagaggttc gttgctatgc caaagaatta cttagacttt ctgaacgtcg tcaagctatt
    23641 tttgataaga tggtggcgtt ggctcaacct ttaccagaag acaagattct acgctctatt
    23701 ccaagtatcg cagaaacaac tgcaacaagt attattggca aactcggtgc tattcgtcgt
    23761 tttcaat
//
