LOCUS       NZ_LS483389            23767 bp    DNA     circular CON 13-FEB-2024
DEFINITION  Streptococcus pyogenes strain NCTC10879 chromosome 1, complete
            sequence.
ACCESSION   NZ_LS483389
VERSION     NZ_LS483389.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1
  AUTHORS   Doyle,S.
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (08-JUN-2018) WTSI, Pathogen Informatics, Wellcome Trust
            Sanger Institute, CB10 1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/13/2024 01:12:56
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,924
            CDSs (total)                      :: 1,835
            Genes (coding)                    :: 1,780
            CDSs (with protein)               :: 1,780
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 55
            CDSs (without protein)            :: 55
            Pseudo Genes (ambiguous residues) :: 0 of 55
            Pseudo Genes (frameshifted)       :: 36 of 55
            Pseudo Genes (incomplete)         :: 21 of 55
            Pseudo Genes (internal stop)      :: 26 of 55
            Pseudo Genes (multiple problems)  :: 22 of 55
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:51:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1318272
            Orig. end                         :: 1342039
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LS483389.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23767
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="4"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..23767
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23767
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13767](-)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13767)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     misc_feature    complement(132..143)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.03"
                     /tool="antismash"
     misc_feature    155..169
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.38"
                     /tool="antismash"
     gene            complement(1396..1896)
                     /locus_tag="DQM81_RS06925"
     CDS             complement(1396..1896)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985256.1"
                     /locus_tag="DQM81_RS06925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="QueT transporter family protein"
                     /protein_id="WP_002985256.1"
                     /transl_table=11
                     /translation="MTKLTVHDYVHIGLVAALYVVLTITPPLNAISYGMYQFRISEMMN
                     FLAFYHRKYIIAVTLGCMIANFYSFGLIDVFVGGGSTLIFVTLGVILFSKYQKDYLFNG
                     IFNKAFVYFSFFFATSMFTVAIELYFFGAPFLLTWFTTALGELVSLLIGSLIIDKLSQR
                     ISF"
     regulatory      complement(1894..2009)
                     /bound_moiety="preQ1"
                     /db_xref="RFAM:RF01054"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF01054"
                     /inference="COORDINATES: profile:INFERNAL:1.1.4"
                     /note="PreQ1 riboswitch class II; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            complement(2174..4906)
                     /locus_tag="DQM81_RS06930"
                     /old_locus_tag="NCTC10879_01395"
     CDS             complement(2174..4906)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985259.1"
                     /locus_tag="DQM81_RS06930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_01395"
                     /product="SpnA family nuclease"
                     /protein_id="WP_063631299.1"
                     /transl_table=11
                     /translation="MINKKCIISVSLLTLAITLTSVEEVTSRQNLTYANEIVTQRPKRE
                     SVISDKSNFPVISPYLASVDFGERKTPLPTPDKGVKVTTEQSIAQVRKGPEERTYTVTG
                     KITSVINGWGGYGFYIQDSEGIGLYVYPQKDLGYSKGDIVQLTGILTRFKGDLQLQQVT
                     AHKKLELSFPTSVKEAVISELETTTPSTLVKLSHVTVGELSTDQYNNTSFLVRDDSGKS
                     IVVHIDHRTGVKGADVVTKISQGDLINLTAILSIVDGQLQLRPFSLEQLEVVKKVTSSN
                     SDASSRNIVKIGEIQGASHTSPLLKKAVTVEQVVVTYLDDSTHFYVQDLNGDGDLATSD
                     GIRVFAKNAKVQVGDVLTISGEVEEFFGRGYEERKQTDLTITQIVAKAVTKTGTAQVPS
                     PLVLGKDRIAPANIIDNDGLRVFDPEEDAIDYWESMEGMLVAVDDAKILGPMKNKEIYV
                     LPGSSTRPLNNSGGVLLPANSYNTDVIPVLFKKGKQIIKAGDSYKGRLAGPVSYSYGNY
                     KVFVDDSKNMPSLMDGHLKPEKTNLQKDLSKLSIASYNIENFSANPSSTKDEKVKRIAE
                     SFIHDLNAPDIIGLIEVQDNNGPTDDGTTDATQSAQRLIDAIKKLGGPTYRYVDIAPEN
                     NVDGGQPGGNIRTGFLYQPERVSLSDKPKGGARDALTWVNGELNLSVGRIDPTNAAWKD
                     VRKSLAAEFIFQGRKVVVVANHLNSKRGDNALYGRVQPVTFKSEQRRHVLANMLAQFAK
                     EGAKHQANIVMLGDFNDFEFTKTIQLIEEGDMVNLVSRHDISDRYSYFHQGNNQTLDNI
                     LVSRHLLDHYEFDMVHVNSPFMEAHGRASDHDPLLLQLSFSKENDKAESSKQSVKAKKT
                     SKGKLLPKTGDSLVYVITLLGTASLLVPILLLTKGKKES"
     misc_feature    5108..5123
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.72"
                     /tool="antismash"
     misc_feature    5229..5240
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 18.98"
                     /tool="antismash"
     misc_feature    5458..5471
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 24.45"
                     /tool="antismash"
     gene            complement(5478..6596)
                     /locus_tag="DQM81_RS06940"
                     /old_locus_tag="NCTC10879_01396"
     CDS             complement(5478..6596)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985264.1"
                     /locus_tag="DQM81_RS06940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_01396"
                     /product="ABC transporter permease"
                     /protein_id="WP_063631298.1"
                     /transl_table=11
                     /translation="MICFIKTLFVKIKRKKTSYVTFFLMPILTTLLALSLSFSNNNQAK
                     IGILDKDNSQISKQFIAQLKQNKKYDIFIKIKKEHIDHYLQDKSLEAVLTIDKGFSDKV
                     LQGKSQKLNIRSIANSEITEWVKAQTNYLLENYNIIGDVALGNEDTFNRILQKNQQLNY
                     DVKQVTLTDRSRSKAVSSTTTGFLLILMLGSTSVIYSGILADKSSQLYHRLMLSNLSRF
                     RYMVSYVCVGFVAFTIQIVIMLSLLKVFNISFFVPTSLLLIIFFLFSLLAIGFGLLIGA
                     ITQNSQQSSQLANLIVMPTSMLAGCLWPLSITPSYMQAIGKLLPQNWVLSAIAIFQSGG
                     TLSQAWPYLLALMGTALALIIFSSLLLKPTRL"
     gene            complement(6593..7720)
                     /locus_tag="DQM81_RS06945"
                     /old_locus_tag="NCTC10879_01397"
     CDS             complement(6593..7720)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985266.1"
                     /locus_tag="DQM81_RS06945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_01397"
                     /product="SagG family ABC transporter permease subunit"
                     /protein_id="WP_011284655.1"
                     /transl_table=11
                     /translation="MVLFHLIKKESLQIFRNRTALLMMVIFPILMIVILSFAFKSSFNT
                     ATTVPKLTIRYQLEGEKTDYQKNFLAFLKVLNQKLHLEAKPSNSLEKDRQRVSEGALTA
                     VLEVKKNQTIKVITNNINQQNADLINMLVKNYVDNAKTYDSIAALYPQQLNHIRKRSVD
                     YVKVSSIQTSKGMTSADYYAISMFTMITFYSMMSAMNLVLSDRQQRITNRIHLTGVSPS
                     LLVFGKLIGAMLATTVQLSLLYIFTRFVLRVNWGTNEWMLIGITASLVYLSVAIGIGLG
                     ISIKNEAFLTVASNTIIPIFAFLGGSYVPLTTLHSSIINQLSNISPIKWVNDSLFYLIF
                     GGQYNPIPVTLIVNISIGTIFIILALIGMRKQVTT"
     gene            complement(7729..8652)
                     /locus_tag="DQM81_RS06950"
                     /old_locus_tag="NCTC10879_01398"
     CDS             complement(7729..8652)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017604.1"
                     /locus_tag="DQM81_RS06950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_01398"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_002990429.1"
                     /transl_table=11
                     /translation="MSFVQLTNVVKSYKNGKKAVNDVSLSIEAGNIYGLLGPNGAGKST
                     LINLILGLIPLSSGKITVLGQSQKTIRKISSQIGYVPQDIAVYPDLTAYENVELFGSLY
                     GLKGAQLKKQVLKSLEFVGLHSQAKQFPSQFSGGMKRRLNIACALVHSPKLIIFDEPTV
                     GIDPQSRNHILESIRLLNKEGATVIYTTHYMEEVEALCDYIFIMDHGQVIEEGPKFELE
                     KRYVANLANQIIVTLTDSRHLELADKPDWSLIEDGEKLMLKIDNSDMTSVVHQLTQANI
                     TFSEIRHNHLNLEEIFLHLTGKKLRD"
     gene            complement(8675..9358)
                     /locus_tag="DQM81_RS06955"
                     /old_locus_tag="NCTC10879_01399"
     CDS             complement(8675..9358)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985270.1"
                     /locus_tag="DQM81_RS06955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_01399"
                     /product="SagF family protein"
                     /protein_id="WP_063631297.1"
                     /transl_table=11
                     /translation="MMLLVLLSFLGLTTLWLTSYRRRCLARWHLQWLMALSYQDFLDVL
                     LSLFQFVVIILVLFFYSATINLGEVLTFLTQTSWHWQILCYLVLYLMAIIEMTLLVLIL
                     IFDVLLQKDSRLLFKKITWLPFRQDKPVLSILLLGIVILVDSLFYLGLLILLGEQSLTS
                     LATLILGYGIVKACRYSGWLNVLLAFCLFTIVGLWAVTATLLYGWLVGVMILTVTYLMI
                     SCKEY"
     gene            complement(9355..10026)
                     /locus_tag="DQM81_RS06960"
                     /old_locus_tag="NCTC10879_01400"
     CDS             complement(9355..10026)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017602.1"
                     /locus_tag="DQM81_RS06960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_01400"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_111688323.1"
                     /sec_met_domain="Abi (E-value: 5e-09, bitscore: 33.3,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLSIQCLNLCFLLVTFCPSIPMQAIFGKEDSGYVFNLIGFLRAT
                     LIYDILALVSIYVLSPQITLSLESIDSKTFFMGLVFCVLIVLIELVFLHGLRCWQKKQW
                     LPATFSFVGTTNDWSKIGYPLLLALFEETIYRFLWFNILAFQWHLPTIIVLIVTSFCYA
                     LNHLLMGKSIFYAKLVTGIIYGSIYMLTSQLWLVVIMHVGGNLLVECLSHLQTKKKKEV
                     T"
     gene            complement(10001..11359)
                     /locus_tag="DQM81_RS06965"
                     /old_locus_tag="NCTC10879_01401"
     CDS             complement(10001..11359)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407460.1"
                     /locus_tag="DQM81_RS06965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_01401"
                     /product="YcaO-like family protein"
                     /protein_id="WP_002990434.1"
                     /sec_met_domain="YcaO (E-value: 6.9e-63, bitscore: 210.1,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 4.2e-111, bitscore:
                     368.2, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLYYYPSFNHIFDELKSLSGNRTGILNQSQVPVCNHPHDVYLKSI
                     TGQMPDYHKQFIGELSQVSYHIIGYGSYYEEALIKYLGESIERYATVIAGDLLSDRIVY
                     ASYNELKLLHKVMPLEYLQVFTQEQIALSCDLQMMMCDKMVTENDVLGWVKCPMFFEDA
                     EMYVPAQMLCVGYKTNETVGERRIIPGFSTGTASHKTLEAAMCNSLIEYIQIDSMMLSW
                     YTKKPCPKIIVDDPDIEVILEEARLGKDSLYDIIPIDMTVGEDNPLYTFGIILKNKYDE
                     GPYLLFGVQAGLDPKHALLRGIMEASAISYSYYYNLLYQKASLANIECEEPLFLDLDSN
                     VFYYAHPKDQDHKWKAFEPLISGEVLLSDLEDHSGKDKKEDLKTLLAYAKKVSPNAVFL
                     DITPPEALEKGWYVTRVLMPELLEMCIPAFPFANHPRMRQFGGVTNAFVHPMP"
     gene            complement(11379..12437)
                     /locus_tag="DQM81_RS06970"
                     /old_locus_tag="NCTC10879_01402"
     CDS             complement(11379..12437)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03603"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cytolysin_C_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985275.1"
                     /locus_tag="DQM81_RS06970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_01402"
                     /product="streptolysin associated protein SagC"
                     /protein_id="WP_002992154.1"
                     /sec_met_domain="Cytolysin_C_RRE (E-value: 1.6e-40,
                     bitscore: 134.1, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03603 (E-value: 8.7e-140, bitscore:
                     462.6, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYQLNSNVRVVTFQDTFCFRKGIWDFNEAILDLTQEPQNLKIVY
                     QEIVSQLVKGVAIDTETYENTLEPETFANLMEVISGLYYNDMLMLEDDYNLEENVMKIL
                     MGNFRFMAQAGHMVSNDPVLFISDSTYVNESAELLAEQLHLQLQVASDDLKMLIQQTDV
                     SSRLDALEHRRNMNCLSEALCDYQSIIICQERLNIMMLRHLNEVSVAMKKQLVIGFVDG
                     PFLHTCTLNPPHSADFDSLERRVLARLQDSTLYQHFANQVLPATQDVSQAYLPLLNVLM
                     NLVVSEAFIIAQTGSSKFEGRLLSIYLPTLEIQVQDILKMSNSQTQGALAKLKYEDQQI
                     STREIVKKLLDE"
     aSDomain        complement(12168..12437)
                     /aSDomain="Cytolysin_C_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing discrete C protein in a
                     SLS/cytolysin LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_DQM81_RS06970_Cytolysin_C_RRE.1"
                     /evalue="2.40E-42"
                     /identifier="RREFam014.1"
                     /label="DQM81_RS06970"
                     /locus_tag="DQM81_RS06970"
                     /protein_end="90"
                     /protein_start="0"
                     /score="134.1"
                     /tool="antismash"
                     /translation="MKYQLNSNVRVVTFQDTFCFRKGIWDFNEAILDLTQEPQNLKIVY
                     QEIVSQLVKGVAIDTETYENTLEPETFANLMEVISGLYYNDMLML"
     gene            complement(12434..13384)
                     /gene="sagB"
                     /locus_tag="DQM81_RS06975"
                     /old_locus_tag="NCTC10879_01403"
     CDS             complement(12434..13384)
                     /codon_start=1
                     /gene="sagB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922108.1"
                     /locus_tag="DQM81_RS06975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_01403"
                     /product="streptolysin S biosynthesis dehydrogenase SagB"
                     /protein_id="WP_010922108.1"
                     /sec_met_domain="PF00881 (E-value: 1.1e-32, bitscore:
                     110.2, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFFTKEQQPKENCPPITVEKARQLFEFNTNHLSLSDYHHQTVLK
                     TSKQLVAQHLMPNATDNLSQHFLMNYKANNNYLGFQASIVDFFTDSAVANFSSSYVYES
                     QEKIIRLPKPTKISTALSTCIIKRRSHRQFSDRQMPLQDLSNILYYACGVSSQASIRDG
                     ASDKITLRNCASGGGLYPIHLVFYARNISKLIDGFYEYLPYQHALRCYRHSSEENVRDF
                     AEYGAINAENCNIIIIYVYHYMKNTRKYGNQATAYAFIESGEIAQNIQLTATALTYGSI
                     DIGGYNKEYLQELLDLDGLGEHVIHMTLVGTKESQ"
     misc_feature    13582..13599
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 22.53"
                     /tool="antismash"
     gene            complement(13606..13767)
                     /gene="sagA"
                     /locus_tag="DQM81_RS06980"
                     /old_locus_tag="NCTC10879_01404"
     CDS             complement(13606..13767)
                     /codon_start=1
                     /gene="sagA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03602"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985285.1"
                     /locus_tag="DQM81_RS06980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_01404"
                     /product="TOMM family cytolysin streptolysin S"
                     /protein_id="WP_002985285.1"
                     /sec_met_domain="TIGR03602 (E-value: 1.8e-29, bitscore:
                     98.4, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKFTSNILATSVAETTQVAPGGCCCCCTTCCFSIATGSGNSQGG
                     SGSYTPGK"
     misc_feature    14293..14306
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.06"
                     /tool="antismash"
     gene            <14330..14446
                     /locus_tag="DQM81_RS06985"
                     /pseudo=""
     CDS             <14330..14446
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611995.1"
                     /locus_tag="DQM81_RS06985"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="IS3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="QETFYSLEQLALKTKEEVHWWNYHHLRSNLNYQTPITK"
     gene            complement(14632..21024)
                     /locus_tag="DQM81_RS06990"
                     /old_locus_tag="NCTC10879_01405"
     CDS             complement(14632..21024)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407459.1"
                     /locus_tag="DQM81_RS06990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_01405"
                     /product="DUF1542 domain-containing protein"
                     /protein_id="WP_172451771.1"
                     /transl_table=11
                     /translation="MFLKHQDVKQKNWRMRKVKKVFVSSCMLLTVGLGVAVPTGFSQSN
                     GVMVVKAEEVPAVENLDVKSFSPIDNLDGWTPEFDSKAYVGKFSQPDRDNFYSIKDGSK
                     STNIKVSPKGNGMLEVKTAARVVYQNSYYVGGIRTTLPTLSKDNLYRVSFNSERIGNSI
                     EFKARVNKLKGDSLGNEVAIRVDNKEMLTTNPWISSLNNGEHTFDFHGNNEPLSLALRF
                     SPRSDHKPGGYKFSNFSIKNISLASKPVPNSPVYEDATTLSGKVIAENAKLDPRKSFVG
                     DEVKIFKDDSLIATVNVSEKNTWTVDNLEVPLKKGDNITVQVINPKSKKTSNKVKIPVL
                     SKPFEPNLYKQQQQAKLEHIYQSTLTNIIQDEWLEDSEKEAQKEKLQSQYAAGKQAIDD
                     AGSQKNAIDEVYKKYSDPQNPDSLPSQYKEGRRELEQEKARRSLEETRDKALEAIRTDP
                     WLDEQDKTTQEEEAKKAFQSGSDKINQTTSLKQLKDQLTIYKADERGTSDKKYPDSILN
                     QHKPGNKKSEQDKAKAELQEVHEKTKKTISEDPWLTDEERNEQLSKEEKAFAKGNQAIE
                     GAQNLTSLREVVQQFSVDEKGAEEKKHPDSLPNQYIPADEQAIKAAKKTSLKELRDTIV
                     SAIQKDLWLTPEEKIKQIQQADEALKKGEVFVENSQNLKELEDGLKNYIIKDNRDESIP
                     NKYQAGKKDELTNKAEVKLKEAHEATKQAIEKDPWLSPEQKKAQKENAKARLDAGLKAV
                     ETTESLDKLKEVESDFLKKEKAESIPSQHQAGTPEVARKTFLDNFEKEAKKEIESIDKD
                     DTLTANAKQVAKDKVAQQLQEATAKVEKAQSFDDLKKVETEFVTALPHTKGEKLNQQQT
                     EAISGLEGVQKATEKAISEDKTLSKDEKKKQIADSKERLKSDTQKVKDAKNADAIKKAF
                     EEGKVNIPQAHIPGDLNKDKEKLLAELKQKADDTEKAIDSDKTLTAKEKEEQKAKTKEE
                     LQKATEAVGAIDNREELDKKVPELKKAIEDTHVKGNLEGVKNKAIEDLKKVHDETVAKI
                     NGDDTLDKATKEAQVKETDKALAAGKDAITKADDADKVGAAVTEHTPKIKAAHKTGDLK
                     KVQEEANQALDKAAEKEREEINKDATLTTEDKAKQLKEVETALTKAKDNVKAAKTADAI
                     NDARDKGVATIDAVHKAGQDLGARKSGQVAKLEEAAKATKDKISADPTLTSKEKEEQSK
                     AVNAELKKAIEAVNAADTADKVDDALGKGVTDIKNQHKTGDPVVARREAHGKQLDRVAQ
                     ETKDAIEKDPTLTTEEKAKQVKDVDAAKERGMAKLTEAKNADELDKAYGEGVTDIKNQH
                     KSGDPIEARRGLHNKSIDEVAQATKDAITADTTLTEAEKETQRGNVDKEATKAKEELAK
                     AKDADALDKAYGDGVTSIKNQHKSGKGLDVRKDEHKKALEAVAKRVTAEIEADPTLTPE
                     VREQQKAEVQKELEIATDKIAEAKDADEADKAYGDGVTAIENAHVIGKGIEARKDLAKK
                     DLAEAAAKTKALIIEDKTLTDDQRKEQLLGVDTEYAKGIENIDAAKDAAGVDKAYSDGV
                     RDILAQYKEGQNLNDRRNAAKEFLLKEADKVTKLINDDPTLTHDQKVDQINKVEQAKLD
                     AIKSVDDAQTADAINDALGKGIENINNQYQHGDGVDVRKATAKGDLEKEAAKVKALIAK
                     DPTLTQADKDKQTAAVDAAKNTAIAAVDKATTADGVNQELGKGITAINKAYRPGEGVKA
                     RKEAAKADLEKEAAKVKALIAKDPTLTQADKDKQTAAVDAAKNTAIAAVDKATTAEGIN
                     QELGKGITAINKAYRPGEGVKARKEAAKADLEREAAKVREAIANDPTLTKADKAKQTEA
                     VAKALKAAIAAVDKATTAEGINQELGKGITAINKAYRPGEGVKARKEAAKANLEKVAKE
                     TKALISGDRYLSETEKAVQKQAVEQALAKALGQVEAAKTVEAVKLAENLGTVAIRSAYV
                     AGLAKDTDQATAALNEAKQAAIEALKQAAAETLAKITTDAKLTEAQKAEQSENVSLALK
                     TAIATVRSAQSIASVKEAKAKGIAAIRAAYVPNKAVAKSSSANHLPKSGDANSIVLVGL
                     GVMSLLLGMVLYSKKKESKD"
     gene            21496..23037
                     /locus_tag="DQM81_RS06995"
                     /old_locus_tag="NCTC10879_01406"
     CDS             21496..23037
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011284650.1"
                     /locus_tag="DQM81_RS06995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_01406"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_111688324.1"
                     /transl_table=11
                     /translation="MLHLHLETKLQDKLSLLNILLDVSEVSIDQLCQETELKKQRVYNL
                     LIEMIKDLEDTLTLTICDDTVSIPYKTYQLKMPYFKKLYQTSIFLKMLCFLIEPGELSL
                     HDFIKREYISQATAYRIRTNCRKYLKKVGLNVRQNHVVGPEYRIRFLIALLHYQFGMTI
                     YDFDKTSMNKVVSLIINSNQAITLNDASKAPYEFSYFAILISLIWKRRHDNLGIPQTDA
                     FKHLKKLSIYHDIKMTSQEIIGKWYHPDLTDEDLDYIFLCFCTTNNPFHKDKWTPKKVK
                     ELFELVMTKTIGKTLKASLRPLLGNNILNSLPFKRILVSFSRLFISNLQVLLPDIHLFH
                     YLRRQQKRNKSFYNTLKTIVEEWMSAEGIVGKLPSYHLLLFTIQLEELLKTYLPPIPAY
                     LLTNNTAALDLMTNALSIYFPPAIATVMPVNVEIIPFKDIVKEKQSVIIADRQYLNLIQ
                     HLYQNQGHLFLYFLFSFRDVSEAYIHKAFLDFRQKRYDEFIVTLLDTYHKNLSSP"
     misc_feature    23115..23126
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
ORIGIN
        1 tcactaccac aagatgggca tagtttagga ataagcatga cttcttgctg gttccgctta
       61 ctcataacga catttaagac agcaggaata atgtcccctg ccttatatac aatcactgta
      121 tcgccaatac ggatatcttt ttcggcaata taatccacat tatgtagggt tgcacgactc
      181 acggttgtcc ccgctagttg cacaggagtt agattcgctg taggtgtgac cacgcctgtt
      241 cgtcccactg tccagtcaac cgaaaggatt tctgcctctt tttcttctgc tggaaatttg
      301 taagcaatag cccagcgtgg agctttaacc gtaaacccta gctcttcttg catggctagg
      361 ctattaactt taataacaac gccatctatg tcataagcta attgatctct ttttgcctca
      421 atagttttga taaaattcca aatctcatcc atagacgatg tgagttgata atacggattt
      481 actgaaaaac ctagatctgc taattctgct aagacctcat tttgttgatt tctagctgtc
      541 ggactagctt cttgatacaa aaaagtggct agttgacgct tagcaaccac tgccgtatct
      601 agctgcctta gtgtcccagc ggcagcattt ctaggattag caaattcagt ctccccattt
      661 tcttggcgtg cttcattgat cgctttaaag gactgacgag acatgtaagc ctctcctcga
      721 acggtgatgg ttaaaggctc actcaattgg tgaggaatat cctttatttt tttaatattt
      781 tctgtgatat tttcaccgat attgccatca ccccgtgttg ctccaacctg taagaagcca
      841 ttctcataac tcaaggaaat agataaacca tcaattttta actctgctag ataggtggca
      901 ttcggaaatt cggccttgac gcgcttatca aaagcatcca gctcctcacg tgaaaaagca
      961 tcctgcaaac taaaaagcgg atactgatgt cgatattttt caaacccctt taaaatagtc
     1021 cctccaacct gctgcgttgg actatcttgc aagacatact cgggatatga ctgctctaaa
     1081 gtcaccagtt cacgataaag cttatcatag tcactgtcag aaactgatgg ggcatcttta
     1141 gtataatagt cataacggta acggttaaga agatctgtta attcttttat gcgttttttc
     1201 atacttttat tttatcataa aagataacaa atgagctatt tctatatcat aacaacatca
     1261 aaagtaatcg ttggccactc catatggtac tattagctaa agtgttaaat atttctatct
     1321 agaacgattt taacattaca aacaacataa aaaagagaag ggtattgacc caactctttt
     1381 gagtatgatg cattactaaa aggaaattct ttgagacaac ttatcaataa taagtgatcc
     1441 tatgagcaga gatactaatt ctcccaacgc agttgtaaac catgttaata aaaatggagc
     1501 tccaaagaag taaagttcga ttgctacagt aaacatggaa gttgcaaaaa agaaagaaaa
     1561 gtaaacaaaa gctttattaa aaatgccatt aaaaagataa tctttttgat acttactaaa
     1621 caaaataaca cctaaggtca caaaaataag agttgaaccg ccgcctacaa agacatcaat
     1681 cagtccgaaa ctataaaagt tagcaatcat acatccaaga gtcaccgcaa taatatactt
     1741 gcgatgataa aaagctaaga aattcatcat ttcagatatt ctaaattgat acatcccata
     1801 agaaatcgca tttaaaggcg gggtaatagt taagacaaca tacaaggcag ctactagccc
     1861 aatgtgaaca tagtcgtgta cagtcaattt tgtcattttt tctcctttaa cgtctggata
     1921 actctcaaaa gctatctacg tttctaatat gcttggtgaa agggaactaa gcaccaaggg
     1981 ttgcaaagca acggttacat tgtaccataa aacaattagc ttgacaaaag tctttagcaa
     2041 gtaaagctgt cttattgtta tcttcttttg ttatcaatat tagtttttat atagtcatcc
     2101 attttagctt aaggtctaac gtaagtatat caagccttta acgactcttt atgaactcca
     2161 attcttcaaa tcgctatgat tcctttttgc ctttagtcaa taataaaata ggcactaata
     2221 aactagccgt tcctagtagc gttatcacat aaacaagact atctcctgtt tttggcaaca
     2281 gttttccttt tgaagttttt ttagctttta cactttgttt agaagactct gccttatcat
     2341 tttctttgga aaatgataat tgaagtaaca atggatcatg atctgatgcg cgtccgtgag
     2401 cttccataaa tggggaattc acatgaacca tgtcaaattc gtagtgatca agtaaatggc
     2461 gtgaaactaa tatattatca agggtctgat tattgccttg gtgaaaataa gaataccgat
     2521 ctgaaatatc atgtcggctc accaagttaa ccatatcacc ttcttcgatt aattgaatcg
     2581 tctttgtgaa ttcaaaatca ttaaagtcac ctagcatcac aatattagct tggtgttttg
     2641 ccccttcttt cgcaaattgt gctagcatat tagccaagac gtgacgtctt tgctcagatt
     2701 taaaagtgac tggttgcaca cgaccataaa gagcattatc cccacgctta gagttcaaat
     2761 gatttgcaac aacaacgact ttacgacctt ggaagataaa ttctgctgct agtgatttac
     2821 gaacatcttt ccaagcggcg ttagttggat caattcgacc aacactaagg tttaattctc
     2881 cattaaccca agttagagca tcacgagcac cgccttttgg cttatcagaa aggctgacgc
     2941 gctctggttg ataaaggaat cctgttcgaa tattaccacc tggttgacct ccgtcaacat
     3001 tattttctgg agcaatatca acataacgat aagtcgggcc acctagtttt ttaatagcat
     3061 caatgaggcg ttgcgcgctt tgtgtcgcat ccgttgtccc atcatcagtc ggcccattat
     3121 tatcttggac ttcaattaat ccaataatgt ctggagcatt cagatcatga ataaaagatt
     3181 cggcaatccg tttgaccttc tcatctttag ttgaagaagg attggctgag aagttttcaa
     3241 tattgtaaga agcaatgctt aacttgctaa ggtctttttg caagtttgtt ttttcaggtt
     3301 ttagatgacc atccattaaa cttggcatgt ttttgctgtc atcaacaaag accttgtaat
     3361 taccatagct ataagatact ggcccagcta atcttccttt gtaagagtct cctgctttaa
     3421 taatttgttt gccttttttg aaaagaacag gaatcacatc tgtgttataa gaattagctg
     3481 gaagtaatac tccacctgaa ttatttaacg gtcttgtact agagccaggt aagacataaa
     3541 tttctttatt tttcattgga ccaaggattt tagcatcatc aaccgccact aacatgcctt
     3601 ccattgattc ccaataatca atagcgtctt cttctggatc aaacacacgc aagccatcat
     3661 tatcaataat attggctggc gcgatacgat ctttccctaa aacaagcggt gatggaactt
     3721 gagctgtccc tgttttggtc actgctttag ccacaatttg ggtgatggta aggtcagtct
     3781 gcttacgttc ctcataacca cgaccaaaga attcttccac ttcacctgaa atggtcaaaa
     3841 catcgccgac ttgaacctta gcgtttttag caaaaacacg aataccatct gaagtcgcca
     3901 aatcaccatc accattaaga tcttgaacat aaaaatgagt ggaatcgtct aaataagtga
     3961 caacaacctg ttctacggtg accgcttttt tgagaagtgg cgacgtatga ctagctcctt
     4021 gaatctcgcc tattttcaca atattacgag atgaagcatc actatttgag cttgtgacct
     4081 ttttaaccac ttccaattgt tcaagagaaa acggtcttaa ttgtaactga ccatcaacaa
     4141 tagacaatat ggctgtgagg ttaatcaaat caccctgact tattttagta acaacatcag
     4201 cccctttaac ccctgtacga tgatctatat gaacaactat acttttacca ctatcatccc
     4261 ttacaaggaa agatgtgttg ttatattgat cagttgataa ttctccaact gtcacgtgag
     4321 ataacttaac taatgttgag ggtgttgttg tttctaattc tgatattact gcttctttaa
     4381 cagaagtcgg aaaagataac tctaactttt tgtgtgcagt cacctgttgg agttgtaaat
     4441 cacctttaaa gcgagtaagt atacctgtta attgaacaat atctccctta ctgtatccta
     4501 aatctttttg aggataaaca taaagtccaa taccttcact atcttgaata taaaagccat
     4561 agcctcccca gccattgatc acactcgtaa tcttgccagt aacagtatag gttctttctt
     4621 caggcccctt tcttacttga gcaatagact gttcagtagt tacttttact cctttatcag
     4681 gtgttggcaa aggtgttttt ctctcaccaa aatccacact tgctaggtaa ggtgatatga
     4741 cgggaaaatt cgatttatca ctaataacag attctctctt tggcctttgt gttacgattt
     4801 cattggcata agtcaaattt tgacgtgaag taacttcttc aacactagta agcgtaatag
     4861 ctagtgtcaa caatgaaaca gatattatac atttcttgtt aatcatgata tctcctttta
     4921 atgtgattag tttaagacaa caacaagatt ttatttttga atattaacct ccacctgaga
     4981 ctatgaattg ggatacactt tctgtttgca ttaattatac tatcaagtaa cacgattaga
     5041 tcttttcttt taatctgtta agtcacccaa ttaaagactt gtttgatctg acataacatc
     5101 acaagcaccc ctgatagcga acaagacagc tttatagcat tcgatacatg cttattgtaa
     5161 caaaaacatt ccataaaata aatacgtttt caaaactttt tttaataaca ttagttttta
     5221 tgtttattga aaacgttttt ttaaaatact ttgacaaccc atttatcaac aaaaacgaac
     5281 tttatagagg ggtcgctttt gataatatgc tctctaaaaa acacagtaac aacagtaaca
     5341 tcgcaatcgc ttttaacaaa agataagtgc actagagaaa atataagcaa aaagcaaccc
     5401 ttttattgca tataagccaa taaaagggct acctggtagt tagctaatta ggaaagtatt
     5461 ttttaacaaa agactaatta tagtctggta ggttttaata ataaacttga aaaaataatc
     5521 aaagctagtg ctgttcccat tagagctaac aagtatggcc aagcctgaga taaggtccct
     5581 ccactttgaa aaatagctat ggctgataaa acccaatttt gtggtagtaa cttaccaatt
     5641 gcttgcatat aagaaggcgt aatagacaat ggccataaac agccagccaa cattgaagtc
     5701 ggcattacaa taagattagc taactggcta ctttgttggg aattttgtgt gatagctcca
     5761 atcagcaggc caaagcctat cgctaataaa ctaaaaagga aaaaaataat caaaagaagt
     5821 gatgtcggaa caaaaaaact aatattaaat acttttaaca aactcagcat aatgacaatt
     5881 tgaatcgtaa aagcaacaaa tcctacacag acgtaactca ccatatagcg aaaacgagat
     5941 aagttcgata acattaatcg atggtataac tgactagatt tatctgccaa aataccactg
     6001 taaatcacgc tcgtactacc taacattaga ataagcaaaa atcctgtcgt tgtggaagat
     6061 actgctttgc tacgtgatcg gtctgtcaaa gttacttgct taacatcata atttaactgt
     6121 tggttttttt ggagaattct attaaaagta tcttcgttac ctagagccac atcccctata
     6181 atattataat tttccaatag ataattggtc tgtgccttta cccactctgt aatttcgcta
     6241 ttagcaatcg aacgtatatt gagtttttga gattttcctt gcaacacttt atctgagaac
     6301 cctttgtcaa tagtcaatac cgcttctaga gatttatctt gaaggtagtg atcaatatgc
     6361 tcttttttga ttttgataaa aatgtcgtac tttttgtttt gctttagttg agcaataaat
     6421 tgtttagata tctgactatt atctttatct aatatcccaa ttttagcttg attattattt
     6481 gaaaaactca aagataaagc caaaagtgtc gttaaaatag gcattaaaaa gaatgtcaca
     6541 taacttgttt ttttgcgttt tatcttaaca aatagagttt ttataaaaca aatcatgtcg
     6601 tcacctgctt tctcatacct atcaatgcca atattataaa aattgttccg atactaatat
     6661 taacgatcaa agttacagga atcggattat attgaccacc aaaaataaga tagaacaaac
     6721 tatcattaac ccatttaata ggagatatat tcgacaattg attaataata gagctgtgta
     6781 atgttgtcaa tggaacgtaa ctgcctccta aaaaggcgaa tataggaata atagtattgg
     6841 atgcaaccgt taaaaaagcc tcatttttaa tgcttatacc tagcccgata cctatagcta
     6901 cagagagata gactaaggag gctgttatac caataagcat ccactcatta gtgccccaat
     6961 taactcgtaa aacaaacctt gtaaaaatgt ataaaagact caattgaaca gttgttgcta
     7021 acatagcacc tattaatttc ccaaagacca aaagacttgg agaaactcct gttaagtgaa
     7081 tacgatttgt aatccgttgt tgacgatctg acaaaacaag gttcatcgca gacatcatac
     7141 tataaaaagt aatcatggta aacatggaaa tagcataata atcagctgat gtcattcctt
     7201 tacttgtctg tattgaactg accttaacat agtccacact tcgctttctg atatgattta
     7261 attgttgagg ataaagagct gctatcgagt cataagtttt agcattatct acataatttt
     7321 ttactagcat attgatcaaa tctgcatttt gctgattaat attattagta ataaccttaa
     7381 tggtctgatt cttcttcact tctaaaacag ccgttaaggc tccttcactg accctttgtc
     7441 gatctttttc aagagaatta ctaggtttag cctctaaatg aagtttttgg tttaaaactt
     7501 ttaaaaaagc aagaaaattt ttctggtaat ccgttttttc accctctaat tggtaacgaa
     7561 tggtcaattt agggactgtt gtcgcagtat taaaacttga tttaaaggca aaacttaaaa
     7621 taacgatcat caaaattgga aaaatcacca tcatcaataa ggctgttcgg tttctaaaaa
     7681 tctgtaaact ttcttttttg attaaatgaa ataaaaccat agtaacctct aatctcgtaa
     7741 cttcttacct gttaagtgta agaaaatttc ttctaaattc aaatggttat gtctaatctc
     7801 gctaaaagta atattggcct gtgtgagctg atgaacaact gatgtcatat cactattatc
     7861 aatcttcaac atgagttttt ctccatcttc tatcaaagac caatcaggct tatctgccag
     7921 ttccaaatga cgtgaatctg ttagagttac aataatctgg tttgctagat ttgcaacgta
     7981 acgtttttcc agttcaaatt taggtccttc ttcaataact tgaccatgat ccataataaa
     8041 aatataatca caaagagcct ctacttcttc catgtaatgg gtcgtataaa taactgtggc
     8101 accttctttg tttagcaaac gaatcgactc taaaatatga ttacgtgatt gaggatcaat
     8161 ccctacagtc ggttcgtcaa aaatgattaa tttaggtgaa tgaactagcg cacaagcgat
     8221 atttaaccgt ctcttcattc ctcctgagaa ttgacttgga aactgcttag cttgggagtg
     8281 tagccccaca aattctaaac tttttagaac ttgtttttta agctgagctc cctttaagcc
     8341 ataaagtgac ccaaatagtt ctacattttc ataagcagtt aggtctggat aaacagcaat
     8401 gtcttgagga acataaccta tctgcgaact tatttttcga atagtctttt gggattgccc
     8461 taaaacagta attttaccgg aactcaaagg gatcaagcct aagataagat taatcaaggt
     8521 agacttacca gcaccatttg gtcctaacag accataaata ttacctgctt caatagacaa
     8581 ggaaacatca ttgacagctt tcttgccgtt tttgtaggac ttgacaacat ttgttaattg
     8641 tacaaaactc atatatcact cctttttaat attgctaata ctctttgcaa ctaatcatca
     8701 aataagtcac cgttaatatc atcacaccta ctagccaacc atataataaa gttgccgtaa
     8761 ctgcccatag tccaactata gtgaaaagac aaaaagctaa tagtacattt aaccaacctg
     8821 aatagcgaca agccttgact atcccataac ctaaaataag cgttgctaaa cttgttagcg
     8881 actgttctcc taataatata agcaagccca aataaaagag actgtctact agaataacta
     8941 tgcctagtaa aagtatactt aagactggtt tatcttgtct aaaaggcagc caagttattt
     9001 ttttaaagag caatcgactg tctttctgga gcaaaacatc aaagataaga attaaaacta
     9061 aaagcgtcat ctctatgatg gccataagat ataacactaa ataacaaaga atctgccaat
     9121 gccagctagt ttgtgtcaaa aaggtcagaa cctctcctag attaatagta gctgagtaaa
     9181 agaacaaaac aagtataata acgacaaatt gaaacagact cagtaagaca tctaaaaaat
     9241 cttgatagga taaggccatt aaccattgaa gatgccatct agccaaacaa cgtcttcgat
     9301 aactggtcaa ccaaagagta gttagaccta aaaacgacag caaaaccaat agcatcatgt
     9361 cacctccttc ttcttttttg tttgaagatg gctaagacac tcaactagca agttacctcc
     9421 tacatgcatt atcacaacca accacaattg actagtcagc atgtaaatac taccataaat
     9481 gatgcctgtt accaacttag cataaaaaat ggatttcccc atcaataagt gatttaaagc
     9541 atagcaaaaa ctagttacaa ttaaaacaat aattgttggt aaatgccatt gaaaagctaa
     9601 tatattaaac cacaaaaaac gataaatcgt ctcttcaaat aaagctagta ataaaggata
     9661 gccaatctta gaccaatcat ttgtcgttcc tacaaacgag aaagttgcag gaagccattg
     9721 ctttttttgc caacaacgta aaccatgtaa gaaaacgagt tcaatcagta ctatcaagac
     9781 gcaaaataca agtcccataa agaacgtctt actatcaata ctttcaagag acaaggttat
     9841 ttgaggtgac aaaacataaa tacttaccaa agccaaaatg tcataaatca gagttgctct
     9901 tagaaaacca attaaattaa atacataacc actatcttcc tttccaaaaa tagcttgcat
     9961 aggaattgaa ggacaaaaag ttaccaacaa aaaacaaaga ttaaggcatt ggatggacaa
    10021 aggcatttgt tacacctcca aactgtctca ttcgtggatg attagcaaaa ggaaatgctg
    10081 gtatacacat ttcaagaagt tctggcatca gaactcgcgt gacgtaccag cctttttcta
    10141 gagcttcagg aggtgtaata tctaaaaaga cagcattagg actgactttc ttagcataag
    10201 ctaataaagt cttcaaatct tcttttttat ctttaccaga atgatcttcc aaatcactta
    10261 acagaacttc tcctgaaatc aaaggttcaa aggccttcca tttatggtct tggtccttgg
    10321 gatgtgcata atagaagaca ttactatcta aatctaaaaa caaaggttct tcgcattcaa
    10381 tatttgcaag ggaagctttt tgatataaaa gattatagta gtaactataa ctaatagctg
    10441 aagcttccat gatccctctt agcaaagcat gtttaggatc taacccagcc tgcactccaa
    10501 acaagaggta aggcccttca tcatatttat ttttgagaat gattccaaac gtataaagag
    10561 gattatcttc tcctacagtc atatcgatag gaataatgtc gtatagactg tcttttccca
    10621 gtctagcttc ttctaaaatc acttcaatat caggatcatc aacaataatc ttggggcaag
    10681 gcttcttagt ataccagcta agcatcattg aatcgatctg gatgtattca atcaaactgt
    10741 tgcacatagc cgcttctaac gttttgtgag aagctgttcc cgtagaaaat cctggtatta
    10801 tccgtctttc tcctacagtc tcatttgttt tatacccaac acaaagcatt tgagctggaa
    10861 catacatctc tgcgtcctca aagaacatgg gacatttaac ccagcccaat acatcgttct
    10921 cagttaccat tttatcgcac atcatcattt gcaagtcaca agataatgcg atctgttctt
    10981 gagtaaacac ttgcaagtat tctaaaggca tcactttatg taacagtttt aactcattat
    11041 aagaagcata gacaatccga tctgatagta agtctccggc aattacagta gcatagcgtt
    11101 caatactttc tcctaaatac ttgataagtg cttcttcata gtaactgccg taaccaataa
    11161 tgtgataact aacttgactc aactcaccta taaattgttt atgataatct ggcatttggc
    11221 cagtaatact ttttaagtaa acatcgtgag gatggttgca aactggaact tgagattgat
    11281 ttaagatacc tgttcgattg ccacttaaac tttttaattc atcaaaaata tgattaaaag
    11341 aaggataata gtataacata atagattctc cttataggtt actcgtcaag gagtttttta
    11401 acaatctcac gtgttgatat ctgctgatcc tcatacttta attttgccaa agctccttgt
    11461 gtctgtgaat tagacatttt caaaatatct tggacctgaa tctcaagcgt cggtaagtaa
    11521 atgcttaata aacgtccctc aaatttagaa ctacctgttt gagcaataat gaaagcttcg
    11581 ctaacgacta aattcattaa aacatttaac aatggtaaat aggcctggct cacatcttgt
    11641 gttgctggta aaacctgatt agcaaaatgt tgatagagag ttgagtcttg taaacgtgcc
    11701 aaaactcttc tttctaagct atcaaagtca gcactatggg gaggattcaa agtacaagtg
    11761 tgcaagaatg gtccatctac aaaaccaatc actaattgtt ttttcatagc tacgctaact
    11821 tcattcaagt gtcgcaacat cataatattc aagcgttctt gacaaataat aatactttgg
    11881 taatcgcaca aggcttctga taaacaattc atgttacggc gatgctccaa agcatctaaa
    11941 cgcgaactaa catctgtctg ctgaattaac atttttaagt catcgctagc cacttgcaat
    12001 tgtaaatgca gttgttcagc tagcaactca gcagattcat taacataagt cgaatcactg
    12061 ataaacaaaa caggatcatt gcttaccata tgacctgctt gcgccataaa acggaaatta
    12121 cccattaaaa ttttcatgac attttcttca agattgtagt catcctcaag catcagcata
    12181 tcattgtaat acaagcctga aatgacttcc attaaattag cgaacgtctc aggttctaaa
    12241 gtattttcat aagtttcagt atcaatggct actcccttaa ccaactgtga aactatttct
    12301 tgataaacta tctttaaatt ttgaggttct tgtgtcaaat ctagaatggc ttcattaaag
    12361 tcccagattc cttttctaaa acaaaatgta tcttgaaatg tcacgacacg aacattacta
    12421 ttaagttgat atttcattga gactccttag ttcctacgag tgtcatgtga atcacatgct
    12481 ctcctagccc atctaaatct aataattctt ggagatattc cttattataa ccaccaatat
    12541 caatacttcc ataagttaag gcagttgcag tcaattgaat attctgggct atttctcctg
    12601 attcaataaa agcataggca gtcgcctgat tcccatattt acgtgtattt ttcatgtaat
    12661 ggtagacata aataataata atattacaat tttcagcatt aatagcaccg tattccgcaa
    12721 aatctctaac gttttcctca gagctatgcc gataacacct tagtgcatgc tgatagggta
    12781 gatattcata gaaaccatct attaatttac tgatgtttct agcataaaaa actaaatgaa
    12841 tagggtataa acctccacct gaagcacagt ttctgagtgt aatcttatct gatgctccat
    12901 ctctaattga tgcttgtgaa ctaacaccac atgcataata aagaatgttt gataaatctt
    12961 gaagaggcat ttgtctatct gaaaattgac gatgacttct tcgttttata atacatgtcg
    13021 acagagcagt tgatatcttg gtaggttttg gtaaacgaat tatcttttcc tgactttcat
    13081 aaacgtaact acttgaaaaa ttagcaacgg cagaatctgt aaaaaagtcg acaatactag
    13141 cttggaagcc taaataatta ttattagctt tatagttcat caaaaaatgt tgactaagat
    13201 tatcggttgc attaggcatt aaatgttgag caactagctg ctttgacgtt tttagcaccg
    13261 tttgatgatg gtaatccgat aaggacaagt ggtttgtatt aaattcaaac aattgccttg
    13321 ctttttcaac agttattggc ggacaattct ctttaggttg ttgttccttt gtaaaaaatg
    13381 acataactat ctttcctatc tcattttact aaacatatag taattagcag gtactgtcta
    13441 gtacctgcta attacctgag acgttagcat caagaagatt acttttgtct catgttttct
    13501 aacacctcta tgccattcat ctataatcag aagttaccaa agataactta gttgctagca
    13561 aactcattac cttaatatca ctatcacata gagatgctaa atagattatt tacctggcgt
    13621 ataacttccg ctaccacctt gagaattacc acttccagta gcaattgaga agcaacaagt
    13681 agtacagcag caacagcagc ctccaggagc aacttgagtt gtttcagcta cactagtagc
    13741 taaaatattt gaagtaaatt ttaacataag gtttacctcc ttatctaata agtaactgat
    13801 aagaacacga gtcgtttatt tttaacctta ttttaaaaat aaagttaaca caacaaggac
    13861 aaggctagct caattgtact gttgtaacac aacaactatc tagttcttat cacttttatt
    13921 atagtaaaaa atgattaata tgtaaaccct ttctttttaa tattatcaaa aatgacaaaa
    13981 aaaataataa ttgattaata tagaaacaat tattatctaa tatactgaat tttataatat
    14041 attctatcaa taactatgtg taaacaatca agtagaaatg tctttattaa gcgaatcaat
    14101 caaggttgta gagtaaatac tggactagat ttcatgtaga aattagtaaa agttaggaga
    14161 ttttttggtc gtttcaaacg ataacatcat cttcttataa caagaacttc actcagagat
    14221 aaactattct aatactttag tagcctcttt tgagcttgta gcacgaaaat tcgctcgaac
    14281 tgatttaaaa taggcatttt atctgctcgc ttgatcccta ctgcgcgacc aagaaacctt
    14341 ttattcacta gaacaattag cccttaaaac caaggaggaa gtccactggt ggaactacca
    14401 tcaccttcgc agtaatctta attatcaaac acccataact aaatgagtta tcgtttgaac
    14461 aaaaaacgcc ttataaattc tgtacagaaa actgttgcct tttcaattga actttggaat
    14521 gttttcaata cactccgttc ttgggccctt acgatccaaa aaaccaaggt gatttcaaaa
    14581 tcaccttggt ttgaaaatat agtagaaagc aatttggata aagccaggtt cttagtcttt
    14641 actttctttt ttcttgctat aaagcaccat acctaaaaga agagacataa ctcctaagcc
    14701 aacaagaaca attgagtttg catcacctga ttttggaaga tggttcgctg acgatgattt
    14761 tgcgactgcc ttattaggca cataggctgc acggatagca gcaatacctt tagcctttgc
    14821 ttctttcaca gacgcaatag attgtgctga acgaacagtc gcaatagctg tcttaagcgc
    14881 taatgataca ttttctgatt gttcagcttt ttgagcttca gtcaatttag catcagttgt
    14941 aatcttagca agtgtttctg ccgcagcttg tttaagagct tcaatagcag cttgtttcgc
    15001 ttcgttaaga gcagctgttg cttgatcagt atctttagct aaaccagcaa catatgctga
    15061 acggatagct acagtaccaa ggttttctgc caacttaaca gcttcaactg tcttagcagc
    15121 ctcaacttga ccaagtgctt tcgcaagagc ttgctcaaca gcttgttttt ggactgcttt
    15181 ttcagtttcg ctcaagtaac ggtctcctga aataagagct ttagtttctt tagctacttt
    15241 ttcaagatta gctttagcag cttctttacg tgctttaaca ccttcacctg gacggtaagc
    15301 tttattgata gctgtgatgc ctttaccaag ttcttggtta atgccttcag ctgttgtcgc
    15361 tttatcaacc gctgcgatag cagctttaag agctttagca acagcttctg tttgtttagc
    15421 tttatcagct tttgttaagg ttgggtcgtt agcgatagct tcacgaacct tagcagcttc
    15481 tctttcaaga tcagccttag cggcttcttt acgtgcttta acaccttcac ctggacggta
    15541 agctttattg atagctgtga tgcctttacc aagttcttgg ttaatgcctt cagctgttgt
    15601 cgctttatca accgctgcaa ttgctgtatt cttagctgcg tcaaccgctg ctgtttgttt
    15661 gtctttatca gcttgagtta aggtcggatc cttagcaata agagctttca ctttagcagc
    15721 ttctttttca agatcagctt tagcggcttc tttacgtgct ttaacacctt cacctggacg
    15781 gtaagctttg ttgatagctg tgatgccttt accaagttct tggttaacac catctgctgt
    15841 cgtcgcttta tcaaccgctg caattgctgt attcttagct gcgtcaaccg ctgctgtttg
    15901 tttgtcttta tcagcttgag tcaaggttgg atccttagca ataagagctt tcactttagc
    15961 agcttctttt tcaagatcgc ctttggcagt cgctttacga acatcaacgc catcgccatg
    16021 ttggtattgg ttgttgatgt tttcaatacc cttaccaaga gcatcattga tagcatcagc
    16081 tgtttgagca tcatcaacag acttgattgc gtctaactta gcttgttcaa ctttgttgat
    16141 ttgatcaact ttttggtcat gagtcaaggt tggatcatca ttgattagtt tcgtcacttt
    16201 gtctgcttct ttaagaagaa attctttggc agcattacga cgatcattaa ggttttgacc
    16261 ttctttgtac tgtgccagga tgtcacgaac accgtcacta tatgctttat caacacctgc
    16321 agcatcctta gctgcatcaa tattctcgat acctttagca tactctgtat caacacctaa
    16381 taactgttct ttacgttgat catcagtaag cgttttgtct tcaataatga gagcttttgt
    16441 cttagcagca gcttcagcaa ggtctttctt agcaaggtct ttacgagctt cgataccttt
    16501 accaataacg tgggcatttt cgatcgctgt gacaccgtca ccgtaagctt tgtctgcttc
    16561 atctgcatct ttagcttcag caatcttatc agtcgcaatt tcaagctctt tttgaacctc
    16621 tgctttttgt tgttctctca cttctggtgt taaggttgga tcagcctcaa tttcagcagt
    16681 gacacgttta gcaacagctt caagagcttt cttgtgctca tctttacgaa cgtcaagacc
    16741 tttacctgac ttgtgttggt tcttgatgct ggttacaccg tcaccatacg ctttgtctaa
    16801 agcatcagca tctttagcct tagcaagttc ttctttagct ttagttgctt ctttatcaac
    16861 attgccacgt tgtgtttctt tttcagcttc agtcaaagtc gtatctgctg tgatagcgtc
    16921 cttagttgct tgcgccactt cgtcgattga cttgttgtgt aatccacgac gagcttcgat
    16981 agggtcacct gacttgtgtt ggttcttgat gtctgtaaca ccttcaccgt aagctttgtc
    17041 taactcatca gcattcttag cttcagtaag cttagccatg cctctttctt tagcggcatc
    17101 tacgtcttta acttgtttag ctttttcttc agtcgtcaaa gtagggtctt tttcaatcgc
    17161 atctttagtt tcttgagcga ctctatcaag ttgcttacca tgagcctcac gacgagctac
    17221 gacagggtca cctgtcttat gttggttctt gatgtctgtg acacctttac caagagcatc
    17281 gtcaaccttg tcagctgtgt cagctgcgtt aacagcttct atcgctttct taagttcagc
    17341 gttaacagct ttagattgct cttctttttc tttgcttgtc aaagttggat cagctgaaat
    17401 cttgtctttc gttgctttag ctgcttcttc aagtttagcg acttgacctg acttacgagc
    17461 acctaagtct tgacctgctt tatgaacggc atcaattgtt gctacgcctt tatcacgtgc
    17521 gtcattgata gcgtctgctg tcttagcagc tttcacgtta tctttagctt tagtaagagc
    17581 tgtctcaact tctttcagtt gttttgcttt atcttctgtc gttagtgtag catctttatt
    17641 gatttcttca cgttcttttt cagctgcttt gtcaagagct tggttagcct cttcttgaac
    17701 ttttttaaga tcaccagttt tatgtgctgc tttaattttt ggtgtgtgct ctgtaacagc
    17761 tgcacccact ttatcagcat catctgcttt agtgatagca tctttacctg ctgccaaagc
    17821 tttgtcagtt tctttcactt gagcttcttt agtagctttg tcaagggtat catcaccatt
    17881 tatcttagca actgtttcgt catgaacttt tttaagatct tcaatagcct tattcttaac
    17941 accttcaaga ttacctttaa cgtgagtgtc ttcaatagct ttcttaagtt ctgggacttt
    18001 tttatctagt tcttcacgat tgtcaattgc tccaacagct tctgttgctt tttgaagttc
    18061 ttcttttgtt ttcgcttttt gctcttcttt ttctttcgct gtcaaagttt tatcggaatc
    18121 aatcgctttt tcagtatcat ctgctttttg cttcaactct gcaagaagtt tttctttatc
    18181 cttgttcaaa tcacctggga tatgtgcttg aggaatattc actttccctt cttcaaatgc
    18241 ttttttaata gcatcagcat ttttagcatc tttaactttt tgcgtgtcag atttcaaacg
    18301 ttccttagag tcagcaattt gtttcttttt ttcatctttt gacagtgtct tatcttctga
    18361 gatagctttt tctgttgcct tttgaactcc ttctaaacca gaaatagctt cagtttgttg
    18421 ttgattaagt ttttcccctt ttgtatgcgg taaagcagtt acaaattcag tctcaacttt
    18481 cttcaaatca tcaaacgact gtgctttctc tactttagct gtagcttctt gtagctgttg
    18541 tgccacttta tctttagcta cttgtttagc atttgccgtt aaggtatcat ctttatcaat
    18601 agattcaatc tcttttttag cttctttttc aaagttatct aagaaagttt tgcgagcaac
    18661 ttcaggagtt cctgcttgat gttgagatgg aatagattct gctttttctt ttttaaggaa
    18721 gtcactctca acttctttaa gtttatctaa actttctgta gtttcgacag ctttcaaacc
    18781 tgcatctaat cttgctttag cgttttcttt ttgagctttt ttctgttccg gactcaacca
    18841 tggatctttt tcaattgctt gtttagtagc ttcgtgagct tccttaagtt taacttcagc
    18901 cttatttgtt aattcatcct tcttaccagc ttgatacttg ttaggaatag actcatctcg
    18961 attatcttta atgatgtaat ttttaagtcc gtcttcaagt tcttttagat tttgtgagtt
    19021 ctcaacaaat acttctcctt ttttcaatgc ttcatcagcc tgttgtattt gtttgatttt
    19081 ttcctctggt gttaaccata aatccttttg gatagctgaa actattgtat cacgtaactc
    19141 tttaagtgat gtttttttag ccgctttgat cgcctgttca tcagccggga tatactgatt
    19201 agggagtgaa tcagggtgtt tcttttcttc agcacctttt tcatcaacag aaaattgttg
    19261 aacgacttct cttagtgaag ttagattttg tgctccttca atagcttgat ttcccttagc
    19321 aaaagctttt tcttctttgc taagttgctc atttctttct tcatctgtta gccatggatc
    19381 ttcactgatt gtttttttag tcttttcatg aacttcttga agttccgcct tggctttgtc
    19441 ctgctcactt ttcttattac ctggtttatg ctggtttagt attgaatcag gatatttttt
    19501 atcagatgtt cctctttcat ctgctttata gatggtaagt tgatctttca attgtttaag
    19561 cgatgtagtt tgattaatct tatcgcttcc tgattgaaac gcttttttcg cttcttcttc
    19621 ttgagttgtt ttatcttgtt cgtccagcca cggatctgtt ctaatagcct ccaatgcttt
    19681 gtctcgagtt tcctctaaac ttctacgagc tttttcctgt tcaagttctc ttcttccctc
    19741 tttatactga cttggcaaag aatctggatt ttggggatct gaatattttt tatatacctc
    19801 atctatagca ttcttttgag aacctgcatc atctatcgct tgtttccctg ctgcatattg
    19861 actctggagt ttctcttttt gagcttcttt ctcagagtct tccaaccatt catcttgaat
    19921 gatattagtt aaagtcgatt gataaatatg ttctaatttt gcctgttgtt gttgtttgta
    19981 aagattaggc tcaaaaggtt ttgataaaac aggaatcttt actttgttac tagttttttt
    20041 agatttagga ttaataactt gaacagttat attgtcacct ttttttaaag gaacctctaa
    20101 attatcaact gtccaagtat ttttttcact tacattcaca gtagcaatta agctatcatc
    20161 tttaaaaatt ttaacttcat ctccgacaaa actttttcga ggatctaact tagcgttttc
    20221 tgctataact tttccagata aagttgtagc atcttcataa actggactat taggtactgg
    20281 tttagaagct aatgaaatat tttttataga aaagtttgaa aacttataac ctccaggttt
    20341 atgatcactt cttggagaaa atcttaaagc caatgataaa ggttcattat ttccgtggaa
    20401 atcaaatgta tgctctccat tatttaagct agatatccat ggattagttg ttaacatttc
    20461 tttattatca acacggatag caacttcatt tcctaaagaa tcacctttta acttgttaac
    20521 cctagcttta aattcaatac tattgcctat acgctcacta ttaaatgaaa cacggtataa
    20581 attatctttt gaaagtgtag gcaatgtagt tctaattcct cctacataat aactgttttg
    20641 gtatactact cttgccgcag tcttaacttc caacattcca tttcctttag gagatacttt
    20701 gatattggta gatttactcc catctttgat actatagaaa ttatcacgat caggttgtga
    20761 aaattttcct acataagctt tagaatcaaa ttcaggcgtc cagccatcta aattatctat
    20821 tggagaaaat gatttaacat ctagattctc caccgccggc acttcctcag cctttacgac
    20881 catcacgcca ttagattggc tgaatccagt aggtacggca actccgaggc ctactgttaa
    20941 aagcatacat gaactaacaa agactttttt gaccttacgc attctccaat ttttttgttt
    21001 cacatcttgg tgttttaaaa acattctgta ttccccctta ttttttcatg cctatcttat
    21061 ttgacgttgt cagccagtag acacccagac tgactgatga cgtgctctac tcttgtagag
    21121 agtttacgtt cctatcacag aatttaagga atcctcctta acttatttta gtcaccttag
    21181 aaacctgtat tttctatgtt cagacagttt aacacgcccc ggaacgttac agctgattag
    21241 aatttaaatg aattattaat ttttctaatc aacttattat atcaacttaa atttacccaa
    21301 ttcaatagat tttttatcaa tcccgacgct ttttcatacc taaaattaag aatattcagc
    21361 tgcattttgc ttatatctga cattcttaat actccttaaa cacgcgtcac cattgaatta
    21421 tttgactgtt ttatttaatt atgtgataat taaataaata cgagtttctg ctataaaaat
    21481 gaaaggagtt cagttatgtt acaccttcat ctagaaacca aactacaaga taaattatca
    21541 ctgctcaaca ttttgttaga cgtttccgaa gtctccatag accagttgtg tcaggaaacc
    21601 gaactcaaaa aacaacgtgt ctacaactta ctcattgaaa tgattaagga tttagaagac
    21661 accctcacct taaccatttg tgacgacact gtttctatcc cctataagac ctaccaactt
    21721 aaaatgcctt attttaagaa actctatcaa acctcgatat tcttaaagat gttatgtttt
    21781 ttaattgaac caggagagct gagcctacac gacttcatta aacgagagta tatttcccaa
    21841 gccaccgctt accgtatcag gaccaattgt cggaaatact tgaaaaaggt aggtttaaac
    21901 gttcggcaaa accatgttgt tggaccagaa taccgtatcc gctttctgat cgccttgttg
    21961 cactatcagt ttggtatgac catttatgat tttgataaaa catcaatgaa taaagtggtt
    22021 tcgctgatta taaactccaa tcaagccatc acacttaatg atgccagtaa agccccttat
    22081 gaattttcgt actttgccat tctgatatcc cttatatgga aacggcgaca tgataacttg
    22141 gggatccctc agacagatgc attcaaacac ttgaaaaaac tgtctatcta tcacgatatc
    22201 aaaatgacca gtcaggaaat catcggaaaa tggtaccatc ctgatttaac tgatgaggat
    22261 ttggattata ttttcttatg tttttgcacc accaataatc ctttccataa ggataaatgg
    22321 acacctaaaa aagtgaaaga attgtttgag ttggtgatga caaaaacaat tggaaaaacc
    22381 ttgaaagcat ccctgcgtcc actactaggc aataatatcc taaactccct tcctttcaaa
    22441 cggattttgg tttccttctc acgtctcttt atcagtaatc ttcaagtttt gttacctgac
    22501 atacacttgt tccattacct cagaagacag caaaaacgaa acaagagctt ctacaatact
    22561 ctaaaaacca tcgttgagga atggatgagc gcagaaggca tcgtggggaa actgccgtcc
    22621 tatcatttac tgctcttcac gatacagtta gaggaactcc taaaaacata tttgccaccg
    22681 atacctgcct atcttttgac caataacact gctgcgctgg atttgatgac caatgcactc
    22741 tcgatttact tcccgccagc tattgcaacg gttatgcctg tcaatgtcga aatcattcct
    22801 ttcaaagata ttgttaagga aaagcagagt gtcattatcg cagataggca atatctgaac
    22861 ctgatacagc atttgtacca gaatcaaggg catttgttct tgtatttctt gtttagtttt
    22921 agagacgttt ctgaggctta cattcataag gcatttctag acttccgcca aaaacggtac
    22981 gatgagttta tcgtgacctt gttggacact taccacaaga acctgtcttc tccttgagtg
    23041 ataaagatgc tttgttcaca ttaccaaaag gctcagcaag ctaatattgt tctaaacggc
    23101 atccacaagg tgagggaact gaacgcaaga gtcaactgca gtaatttgag aaataccgtt
    23161 cgactgatgg actgttaggg cattgagatt attaagaaga aacagtatca gacttattct
    23221 tctagaataa aggaaaaaat cattaataac atcttgaaaa acggctatac tattgtttaa
    23281 aaggcaaaag ggagaccatc acaacaggag tctattctcg tcggcttcag tccttccttg
    23341 agaaaaatgg ctacgcttat acacaactca atcctttaga aaactagata gtctacgggt
    23401 gcgtaaagcg gataagttag acactgaaaa attggctcag tctcaattta ttctagttag
    23461 aaaaccaact tacgttcagg aagaagttta tcagctgcta cgtgacttga gtcgcttcta
    23521 tcaaaaattg actgaggata atattgttcg agagttaaga atcgccttca caagatctta
    23581 caagtcactt ttcctgaact ggaacacatc ttatttgcac caactggtga gtaatactgg
    23641 aatgtggtaa cggcttttcc atgtaatagc tttgtactgg agctagctga caaagcattg
    23701 tcagctatca tccgtcaatc tacctctaaa cgtatctctg acaagcgtgg gatctactta
    23761 gtggaaa
//
